>Homo_sapiens_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MA ALMRSKDSSCCLLL--LAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAG------------------------ ------------------------------------------------------MYQGLAFGGSKKGKNL---------- ---GQAYPCSSDKECEVGRYCHSPHQGSSA-------------------------------------------------- -------------CMVCRRKKKRC-------------------------------HRDGMCCPST--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGTRHRD -------------------------------------------------------------------------------- -------------------------------------------------------RNHGHYSNHDLGWQNLGRPHTKMSH IK----------------------------------------------------------------GHEGDPCLR----- SSDCI----------------------------------EGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gorilla_gorilla_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----AYPCSSDKECEVGRYCHSPHQGSSA-------------------------------------------------- -------------CMVCRRKKKRC-------------------------------HRDGMCCPGT--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGTRHRD -------------------------------------------------------------------------------- -------------------------------------------------------RNHGHYSNHDLGWQNLGRPHTKMSH IK----------------------------------------------------------------GHEGDPCLR----- SSDCI----------------------------------EGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Macaca_mulatta_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MA ASMRCKDSSRCLLL--LAAVLMVESSQIGSSRAKLNSIKSSLGGETPAQAANRSAG------------------------ ------------------------------------------------------IYQGLAFGGSKKGKNL---------- ---GQAYPCSSDKECEVGRYCHSPHQGSSA-------------------------------------------------- -------------CMVCRRKKKRC-------------------------------HRDGMCCPGT--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGTRHRD -------------------------------------------------------------------------------- -------------------------------------------------------RNHGHYSNHDLGWQNLGRPHTKMSH IK----------------------------------------------------------------GHEGDPCLR----- SSDCI----------------------------------EGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Mus_musculus_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MA ALMRVKDSSRCLLL--LAAVLMVESSQLGSSRAKLNSIKSSLGGETPAQSANRSAG------------------------ ------------------------------------------------------MNQGLAFGGSKKGKSL---------- ---GQAYPCSSDKECEVGRYCHSPHQGSSA-------------------------------------------------- -------------CMLCRRKKKRC-------------------------------HRDGMCCPGT--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGTRHRD -------------------------------------------------------------------------------- -------------------------------------------------------RNHGHYSNHDLGWQNLGRPHSKMPH IK----------------------------------------------------------------GHEGDPCLR----- SSDCI----------------------------------DGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Oryctolagus_cuniculus_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MAGKDSSRCLLL--LAAVLMVESSQLGNSRAKLNSIKSSLGGETPAQAANRSAG------------------------ ------------------------------------------------------IYQGLAFGGSKKGKNL---------- ---GQAYPCSSDKECEVGRYCHSPHQGSSA-------------------------------------------------- -------------CMVCRRKKKRC-------------------------------HRDGMCCPGT--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGTRHRD -------------------------------------------------------------------------------- -------------------------------------------------------RNHGHYSNHDLGWQNLGRPHTKMSH IK----------------------------------------------------------------GHEGDPCLR----- SSDCI----------------------------------EGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------SYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Canis_familiaris_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MA AWMRGKDSSRCLLL--LAAVLMVESSQLGGSRAKLNSIKSSLGGETPAQVANRSAG------------------------ ------------------------------------------------------TYQGLAFGGSKKGKNL---------- ---GQAYPCSSDKECEIGRYCHSPHQGSSA-------------------------------------------------- -------------CMVCRRKKKRC-------------------------------HRDGMCCPGT--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGTRHRD -------------------------------------------------------------------------------- -------------------------------------------------------RNHGHYSNHDLGWQNLGRQHTKMSH IK----------------------------------------------------------------GHEGDPCLR----- SSDCI----------------------------------EGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Equus_caballus_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MA ALMRSKDSSRCLLL--LAAVLMVESSQLGSSRAKLNSIKSSLGGETPAQAANRSAG------------------------ ------------------------------------------------------TYQGLAFGGSKKGKNP---------- ---GQAYPCSSDKECEVGRYCHSPHQGSSA-------------------------------------------------- -------------CMVCRRKKKRC-------------------------------HRDGMCCPGA--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGTRHRD -------------------------------------------------------------------------------- -------------------------------------------------------RNHGHYSNHDLGWQNLGRPHTKMPH IK----------------------------------------------------------------GHDGDPCLR----- SSDCI----------------------------------EGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Loxodonta_africana_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MA ALMRGKDSSCCLLL--LAAVLMVESSQLGSSRAKLNSIKSSLGGETPAQAANRSAG------------------------ ------------------------------------------------------IYQGLAFGGSKKGKNL---------- ---GQAYPCSSDKECEVGRYCHSPHQGSSA-------------------------------------------------- -------------CMVCRRKKKRC-------------------------------HRDGMCCHGT--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGARHRD -------------------------------------------------------------------------------- -------------------------------------------------------RNHGHYSNHDLGWQNLGRPHSKMSH IK----------------------------------------------------------------GHEGDPCLR----- STDCI----------------------------------EGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Monodelphis_domestica_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MT LMMWNKESSRCLLL--LAAVLMVESSQLGSSRSKLNSIKSVLGGETPTQATNRSAA------------------------ ------------------------------------------------------VYQGLTFGSSKKGKNLGQVGKSSKHN HQQGEAYPCSSDKECEVGRYCNSPHQGSSA-------------------------------------------------- -------------CLVCRRKKKRC-------------------------------HRDGMCCPGT--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGMRHRD -------------------------------------------------------------------------------- -------------------------------------------------------RNHGHYSHHDLGWQNLGRPHSKMSH IK----------------------------------------------------------------GHEGDPCLR----- SSDCM----------------------------------EGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gallus_gallus_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MI VLMWNK-CSCCLLL--LAAVLIVESSQLDSSSSKVNSIKSTLMGEAPTQATNRSAG------------------------ ------------------------------------------------------IHQGLKLASSKKGKMLEQMRKPPKHY HRQGEVYPCTNDKECEVGRYCHSPHQASSA-------------------------------------------------- -------------CMLCRRKKKRC-------------------------------HRDGMCCPGN--------------- RCNNG-ICVPVTENILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALDGPR--N -------------------------------------------------------------------------------- -------------------------------------------------------KKNSHYTSKDLGWQNLGRAQSKLSH IK----------------------------------------------------------------GHEGDPCLR----- SSDCI----------------------------------EGHC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TSSSKSRLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Taeniopygia_guttata_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MI VLMWNK-CSCCLLL--LAAVLIVESSQLDSSSSKVNSIKSTLMGEAPTQATNRSAG------------------------ ------------------------------------------------------IHQGLMLASMKKS------------- CQSQTAYPCTNDKECEVGRYCHSPHQATSA-------------------------------------------------- -------------CMLCRRKKKRC-------------------------------HRDGMCCPGN--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALEGPR--N -------------------------------------------------------------------------------- -------------------------------------------------------KKNGHYASKDLGWHNLGRPRSKLSH IK----------------------------------------------------------------GHEGDPCLR----- SSDCI----------------------------------EGHC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TSSSKSRLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Anolis_carolinensis_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MG VRGGSRGSSPRPLL--FLAALLVAAESSQPEGAQANAIKATLLGEAPTQATNRSTP------------------------ ------------------------------------------------------FHQGGAPGSGKKSKLFGPGGKGLKHY HRQGEAYPCTNDKECEVGKYCHSPHQAISA-------------------------------------------------- -------------CMICRRKKKRC-------------------------------HRDGMCCPGN--------------- RCNNG-ICIPVTESILT--------------------------------------------------------------- -------------------------------------------------------------------PHIPALEVPR--N -------------------------------------------------------------------------------- -------------------------------------------------------KKNNHYPTKDLGWQNLGKGQTKLTH LK----------------------------------------------------------------GHEGDPCLR----- SSDCS----------------------------------EGFC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLNCKI------------ ----WKDA-----------------TYSSKARLHVCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Xenopus_tropicalis_DKK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MNMV LLGMNGECCCLLPL--LAAVLMVESSQLDVSSSKMNAIKSVLLVQTPTAATNKSES------------------------ ------------------------------------------------------IHHG---VSHKKGKSN---------- ---GQAYPCISDKECEVGRYCYSPHQAPSS-------------------------------------------------- -------------CMLCRRKKKRC-------------------------------HRDGMCCPGN--------------- RCNNG-ICIPVAETIMS--------------------------------------------------------------- -------------------------------------------------------------------PHIPALETRP--- -------------------------------------------------------------------------------- -------------------------------------------------------KKNGHISNKDLGWQNLGKHHSKIPL IK----------------------------------------------------------------GHEGDPCLR----- STDCI----------------------------------EGHC-------------------------CARHFWT----- -------------------------------------------KICKPVLHQ--------------------GEVCTKL- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TYSSKSRLHICQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Danio_rerio_DKK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MLTVTRSRCCWMLPLIVAFVRMGETQGIESQAQVNSIKS--LEPQP-AAANRSG------------------------- --------------------------------------------------------ASYSGIPKKSN------------- -IPAQGYPCSSDKECVVGTYCHSPQHAPSR-------------------------------------------------- -------------CLSCRRRKKRC-------------------------------HRDNMCCPGN--------------- RCSNY-ICIPISESALS--------------------------------------------------------------- -------------------------------------------------------------------SHKSSMD------ -------------------------------------------------------------------------------- --------------------------------------------------------ENNKFSIKEKNWKKNGKAHAKISL KG-----------------------------------------------------------------HEGDPCLR----- SSDCS----------------------------------EGYC-------------------------CARHFWT----- -------------------------------------------KICKPVLRQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLACKV------------ ----WKDA-----------------TSFSRSRLHVCQRI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Takifugu_rubripes_DKK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------L RMLFLTWNRCCVVM-FLVAILNMGTSQVSETRPKANSIKPAGLEDAPTPATNRST------------------------- --------------------------------------------------------TAHSRITKKYN------------- -ILKQVYPCSSDKECSLGSYCHSPHHAPSR-------------------------------------------------- -------------CLNCRRRKKRC-------------------------------NRDAMCCPGN--------------- RCSNY-ICVPISESVLS--------------------------------------------------------------- -------------------------------------------------------------------PHISPLD------ -------------------------------------------------------------------------------- --------------------------------------------------------EHNKHPTREHSWRKSGKMHAKHPL KR-----------------------------------------------------------------HEGDACLR----- SSDCL----------------------------------EGYC-------------------------CARHFWT----- -------------------------------------------KICKPVLRQ--------------------GEVCTKQ- RK--------------------------------------------KGAHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TSSTKSRLHMCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Tetraodon_nigroviridis_DKK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------FSP RMFILTWNRCCIVM-FLAAILNMGTSQVSETRPKANSIKPAGLEEVPTPATNRST------------------------- --------------------------------------------------------TVHSRITKKHN------------- -ILTQVYPCSSDKECSMGSYCHSPHHAPSR-------------------------------------------------- -------------CLNCRRRKKRC-------------------------------NRDAMCCPGN--------------- RCSNY-VCIPISESVLS--------------------------------------------------------------- -------------------------------------------------------------------PHISPLD------ -------------------------------------------------------------------------------- --------------------------------------------------------EHNKHSTKEHSWRKSGKMHAKHPL KT----------------------------------------------------------------GHEGDACLR----- SSDCL----------------------------------EGYC-------------------------CARHFWT----- -------------------------------------------KICKPVLRQ--------------------GEVCTKQ- RK--------------------------------------------KGAHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TSSTKSRLHMCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gasterosteus_aculeatus_DKK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------LGSV WMLVLTWDRCCALM-VLVATLRTGTTLLSEAHPKANLIKPALSGGTPTPATNLSD------------------------- --------------------------------------------------------AVHLGITKKHYT------------ -LAQQVYPCSNDKECSVGSYCHSPQQAPSR-------------------------------------------------- -------------CLSCRRRKKRC-------------------------------HRDAMCCPGN--------------- RCSNY-MCVPISESVLS--------------------------------------------------------------- -------------------------------------------------------------------PHIPALD------ -------------------------------------------------------------------------------- --------------------------------------------------------EHNKLSNKDHGWRKSGKGHAKHSL KG-----------------------------------------------------------------HEGDPCLR----- SSDCS----------------------------------EGYC-------------------------CARHFWT----- -------------------------------------------KICKPVLRQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TSSSKSRLHMCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Oryzias_latipes_DKK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------VVS RMLATTWNRCCVLM-FLIVSVRT---DASEGRPKENSIKSGLIEEKPTAATNRSAG------------------------ ------------------------------------------------------LVSVTQIHGFCKGH------------ -GAEQVYPCSNDKECSVGSYCHSPQQSPSR-------------------------------------------------- -------------CLSCRRKMKRC-------------------------------NRDSMCCPGN--------------- RCSNY-ICVPVFESVLS--------------------------------------------------------------- -------------------------------------------------------------------PHIPALD------ -------------------------------------------------------------------------------- --------------------------------------------------------EHSKHSTKYHSWRKKGKAQAKHSL KG-----------------------------------------------------------------HEGDPCLR----- SSDCS----------------------------------EGYC-------------------------CARHFWT----- -------------------------------------------KICKPVLRQ--------------------GEVCTKQ- RK--------------------------------------------KGSHGLEIFQRCDCAKGLSCKV------------ ----WKDA-----------------TSLSKSRLHMCQKI----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Homo_sapiens_DKK4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MVAAVL----LGLSWLCSPLGALVLDFNNIRSSADLHGARKGS----------------------------- -------------------------------------------------------------------------------- -------QCLSDTDCNTRKFCLQPR-DEK-PF------------------------------------------------ -------------CATCRGLRRRC-------------------------------QRDAMCCPGT--------------- LCVND-VCTTMEDATPI--------------------------------------------------------------- -------------------------------------------------------------------LERQLDEQDGTHA -------------------------------------------------------------------------------- -------------------------------------------------------EGTTGHPVQENQPKRKPSIKKSQGR KG----------------------------------------------------------------QE-GESCLR----- TFDCG----------------------------------PGLC-------------------------CARHFWT----- -------------------------------------------KICKPVLLE--------------------GQVCSRRG HK--------------------------------------------DTAQAPEIFQRCDCGPGLLCRS------------ ----QLTS-----------------N-RQHARLRVCQKIEKL-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gorilla_gorilla_DKK4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MVAAVL----LGLSWLCSPLGALVLDFNNIRSSADLHGARKGS----------------------------- -------------------------------------------------------------------------------- -------QCLSDTDCNTRKFCLQPH-NEK-PF------------------------------------------------ -------------CATCRGLRRRC-------------------------------QRDAMCCPGT--------------- LCVND-VCTTMEDATPI--------------------------------------------------------------- -------------------------------------------------------------------LERQLDEQDGTHA -------------------------------------------------------------------------------- -------------------------------------------------------EGTTGHPVQENQPKRKPSIKKSQGR KG----------------------------------------------------------------QE-GESCLR----- TFDCG----------------------------------PGLC-------------------------CARHFWT----- -------------------------------------------KICKPVLLE--------------------GQVCSRRG HK--------------------------------------------DTAQAPEIFQRCDCGPGLLCRS------------ ----QLTS-----------------N-QQHARLRVCQKIEKL-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------