>Homo_sapiens_ANK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------MPYSVGFREADAATSFLRAARSGNL DKALDHLRNG--VDINTCNQ-NGLNGLHLASKEGHVKM---------------------------------VVELLHKEI ILETTTKK------GNTALHIAALAGQDEVVRELVNYGANVNAQ--SQK--GFTPLYMAAQENHLEVVKFLLENGANQNV ATEDGFT--PLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTG----------- --FTPLHIAAHYENLNVAQLLLNRGAS------VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------LTPLHCAARNGHVRIS EILLDH-GAPIQAKTKNG---LSPIHMAAQGDHLDCVRLLLQYDAEIDDITL----------DHLTPLHVAAHCGHHRVA KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS- -----NV--KVETPLHMAARAGHTEVAKYLLQNKAKVNA-------------------KAKDDQTPLHCAARIGHTNMVK LLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA GK-NGLTPLHVAVHHNNL---------------------------DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV ARSLLQYGGSAN----------AESVQGVTP-----------------------------------LHLAAQEGH----- -----AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI---------------------------------- -------------------------------------------------------------------KHGVMVDATTRMG YTPLHVASH----------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------YGNIKLVKFLLQHQADVN-AKTKLGY---------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------SPLHQ AAQQGHTDIVTLLLKNGASPNEVSS------------------------------------------------------- -------------------------------------------------------------------------------- ------------DGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVS---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DKHRMSFPETVDEILDVSEDE---------------------------------------GE ELISFKAE--------------RR--DSRDVDEEKE---------------------------------------LLDFV PKLDQVV---------------ESPAIP----------RIPCAMPETVVIR------SEEQEQASKEYDEDSLIPSSPAT ETSDN-ISPVASPVHTG--------------------------------------------------------------- -------------------------------------------------------------------FLVSFMVDARGGS MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPP---------------------PLAEEEGLASRIIALGPTGAQ FLS---------------------------------PVIVEIPHFASHGRGDRELVVLRSENG-SVWKEHRSRYGESYLD QI---LNGMDEEL-GSLEELE-KKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK LALQ--AQPVP---------------------------------------------DELVTKLLGNQATFSP------IV TVEPRRRKFHR-------PIGLR--IPLPPSWTDNPRDSGEGDTT------SLRLLCSVI----GGTDQA---QWEDITG TTKLVYANECANFTTNVSA-RFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM-NDPREGRLRCYCMTDDKV-D KTLEQH-ENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQ-RSFHFQSFRENRLAMPVKVRD---SSREPGGSLSF LRKAMK---YEDTQHILCHLNITMP------------------PCAKGSGAEDRRRTPTPLALRY--------------- ----SILSESTPGSLSGTEQAEMKMAVISEHLGLSWA------------------------------------------- -----------------------------------------------ELARELQFSVEDINRIRVENPNSLLEQSVALLN LWVIREGQNANMENLYTALQ-----SIDRGEIVNMLEG---SGRQSRNLKPDRRHTDRDYS-LSPSQMNGYSSLQDELLS PASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSK-AEDSDATGHEWKL EGALSEEPRGPE-LGSLELVED---DTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQD------------- -----------------------------------------SENEVSLVSGHQRGQARITHSPTVS-QVTERSQ------ -------------------------DRLQDWDADGSIVS------YLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGG SQEYEK-------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----VLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKII RKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKVELRGSGL---------QPDLIEGRKGAQIVKRAS LKRGKQ-------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRR-----NRSRDRKKKADAATSFLRAARSGNL DKALDHLRNG--VDINTCNQ-NGLNGLHLASKEGHVKM---------------------------------VVELLHKEI ILETTTKK------GNTALHIAALAGQDEVVRELVNYGANVNAQ--SQK--GFTPLYMAAQENHLEVVKFLLENGANQNV ATEDGFT--PLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTG----------- --FTPLHIAAHYENLNVAQLLLNRGAS------VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDE------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------LTPLHCAARNGHVRIS EILLDH-GAPIQAKTKNG---LSPIHMAAQGDHLDCVRLLLQYNAEIDDITL----------DHLTPLHVAAHCGHHRVA KVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS- -----NV--KVETPLHMAARAGHTEVAKYLLQNKAKANA-------------------KAKDDQTPLHCAARIGHTGMVK LLLENG--ASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAA GK-NGLTPLHVAVHHNNL---------------------------DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEV ARSLLQYGGSAN----------AESVQGVTP-----------------------------------LHLAAQEGH----- -----TEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVPVADVLI---------------------------------- -------------------------------------------------------------------KHGVTVDATTRMG YTPLHVASH----------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------YGNIKLVKFLLQHQADVN-AKTKLGY---------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------SPLHQ AAQQGHTDIVTLLLKNGASPNEVSS------------------------------------------------------- -------------------------------------------------------------------------------- ------------NGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVS---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DKHRMSYPETVDEILDVSEDEG-------------------------------TAHISIMGD ELVGSKAE--------------RR--DSRDVGEEKE---------------------------------------LLDFV PKLDQVV---------------ESPAIP----------RIPCVTPETVVIR------SEDQEQASKEYDEDSLIPSSPAT ETSDN-ISPVASPVHTG--------------------------------------------------------------- -------------------------------------------------------------------FLVSFMVDARGGS MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLNTPP---------------------PLAEEEGLASRIIALGPTGAQ FLS---------------------------------PVIVEIPHFASHGRGDRELVVLRSENG-SVWKEHKSRYGESYLD QI---LNGMDEEL-GSLEELE-KKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLRSKLVPLVQATFPENAVTKKVK LALQ--AQPVP---------------------------------------------DELVTKLLGNQATFSP------IV TVEPRRRKFHR-------PIGLR--IPLPPSWTDNPRDSGEGDTT------SLRLLCSVI----GGTDQA---QWEDITG TTKLIYANECANFTTNVSA-RFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKM-NDAREGRLRCYCMTDDKV-D KTLEQH-ENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQ-RSFHFQSFRENRLAIPVKVRD---SSREPGGFLSF LRKTMK---YEDTQHILCHLNITMP------------------PCTKGSGAEDRRRTLTPLTLRY--------------- ----SILSESRLGFTSDTDRVEMRMAVIREHLGLSWA------------------------------------------- -----------------------------------------------ELARELQFSVEDINRIRVENPNSLLDQSTALLT LWVDREGENAKMENLYTALR-----NIDRSEIVNMLEG---SGRQSRNLKPERRHGDREYS-LSPSQVNGYSSLQDELLS PASLQYALPSPLCADQYWNEVAVIDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSK-AEDSDAIP-EWKL EGAHSEDTQGPE-LGSQDLVED---DTVDSDATNGLADLLGQEEGQRSE------KKRQEVSGTEQD------------- -----------------------------------------TETEVSLVSGQQRVHARITDSPSVR-QVLDRSQ------ -------------------------ARTLDWDKQGSTAV------HPQEATQSSWQEEVTQGPHSFQRRITTIQGPEPGA LQEYEQ-------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----VLVSTREHVQRGPPETGSPKAGKE-------PSLWAPESAFSQEVQGDELQNIPGEQVTEEQFTDEQGNIVTKKII RKVVRQVDSSGAIDTQQHEEV-------------------------ELRGSGL---------QPDLIEGRKGAQIVKRAS LKRGKQ-------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------- >Pan_troglodytes_ANK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------MPYSVGFREADAATSFLRAARSGNL DKALDHLRNG--VDINTCNQ-NGLNGLHLASKEGHVKM---------------------------------VVELLHKEI ILETTTKK------GNTALHIAALAGQDEVVRELVNYGANVNAQ--SQK--GFTPLYMAAQENHLEVVKFLLENGANQNV ATEDGFT--PLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTG----------- --FTPLHIAAHYENLNVAQLLLNRGAS------VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------LTPLHCAARNGHVRIS EILLDH-GAPIQAKTKNG---LSPIHMAAQGDHLDCVRLLLQYDAEIDDITL----------DHLTPLHVAAHCGHHRVA KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS- -----NV--KVETPLHMAARAGHTEVAKYLLQNKAKVNA-------------------KAKDDQTPLHCAARIGHTNMVK LLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA GK-NGLTPLHVAVHHNNL---------------------------DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV ARSLLQYGGSAN----------AESVQGVTP-----------------------------------LHLAAQEGH----- -----AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI---------------------------------- -------------------------------------------------------------------KHGVMVDATTRMG YTPLHVASH----------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------YGNIKLVKFLLQHQADVN-AKTKLGY---------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------SPLHQ AAQQGHTDIVTLLLKNGASPNEVSS------------------------------------------------------- -------------------------------------------------------------------------------- ------------DGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVS---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DKHRMSFPETVDEILDVSEDEG-------------------------------TAHITIMGE ELIGFKAE--------------RR--DSRDVDEEKE---------------------------------------LLDFV PKLDQVV---------------ESPAIP----------RIPCAMPETVVIR------SEEQEQASKEYDEDSLIPSSPAT ETSDN-ISPVASPVHTG--------------------------------------------------------------- -------------------------------------------------------------------FLVSFMVDARGGS MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPP---------------------PLAEEEGLASRIIALGPTGAQ FLS---------------------------------PVIVEIPHFASHGRGDRELVVLRSENG-SVWKEHRSRYGESYLD QI---LNGMDEEL-GSLEELE-KKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK LALQ--AQPVP---------------------------------------------DELVTKLLGNQATFSP------IV TVEPRRRKFHR-------PIGLR--IPLPPSWTDNPRDSGEGDTT------SLRLLCSVI----GGTDQA---QWEDITG TTKLVYANECANFTTNVSA-RFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM-NDPREGRLRCYCMTDDKV-D KTLEQH-ENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQ-RSFHFQSFRENRLAMPVKVRD---SSREPGGSLSF LRKAMK---YEDTQHILCHLNITMP------------------PCAKGSGAEDRRRTPTPLALRY--------------- ----SILSESTPGSLSGTEQAEMKMAVISEHLGLSWA------------------------------------------- -----------------------------------------------ELARELQFSVEDINRIRVENPNSLLEQSVALLN LWVIREGQNANMENLYTALQ-----SIDRGEIVNMLEG---SGRQSRNLKPDRRHTDRDYS-LSPSQMNGYSSLQDELLS PASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSK-AEDSDATGHEWKL EGALSEEPRGPE-LGSLELVED---DTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQD------------- -----------------------------------------SENEVSLVSGHQRGQARITHSPTVS-QVTERSQ------ -------------------------DRLQDWDADGSIVS------YLQDAAQGSWQEEVTQGPHSFQGTSTTTEGLEPGG SQEYEK-------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----VLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKII RKVVRQIDLSSADAAQEHEED---------------------------HTSTP---------NP---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------- >Macaca_mulatta_ANK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------AMAQAAKQLKKIKDIEAQALQEQKEKEESNRKRR-----NRSRDRKKKADAATSFLRAARSGNL DKALDHLRNG--VDINTCNQ-NGLNGLHLASKEGHVKM---------------------------------VVELLHKEI ILETTTKK------GNTALHIAALAGQDEVVRELVNYGANVNAQ--SQK--GFTPLYMAAQENHLEVVKFLLENGANQNV ATEDGFT--PLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTG----------- --FTPLHIAAHYENLNVAQLLLNRGAS------VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------LTPLHCAARNGHVRIS EILLDH-GAPIQAKTKNG---LSPIHMAAQGDHLDCVRLLLQYDAEIDDITL----------DHLTPLHVAAHCGHHRVA KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS- -----NV--KVETPLHMAARAGHTEVAKYLLQNKAKVNA-------------------KAKDDQTPLHCAARIGHTNMVK LLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLEQDAHPNAA GK-NGLTPLHVAVHHNNL---------------------------DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVDV ARSLLQYGGSAN----------AESVQGVTP-----------------------------------LHLAAQEGH----- -----AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI---------------------------------- -------------------------------------------------------------------KHGVMVDATTRMG YTPLHVASH----------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------YGNIKLVKFLLQHQADVN-AKTKLGY---------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------SPLHQ AAQQGHTDVVTLLLKNGASPNEVSS------------------------------------------------------- -------------------------------------------------------------------------------- ------------DGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVS---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DKHRMSFPETVDEILDVSEDEG-------------------------------TAHITIMGE ELIGSKPE--------------RP--DSRDVDEEKE---------------------------------------LLDFV PKLDQVV---------------ESPAIP----------RIPCVTPETVVIR------SEEQEQASKEYDEDSLIPSSPAT ETSDN-ISPVASPVHTG--------------------------------------------------------------- -------------------------------------------------------------------FLVSFMVDARGGS MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPP---------------------PLAEEEGLASRIIALGPTGAQ FLS---------------------------------PVIVEIPHFASHGRGDRELVVLRSENG-SVWKEHRSRYGESYLD QI---LNGMDEEL-GSLEELE-KKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK LALQ--AQPVP---------------------------------------------DELVTKLLGNQATFSP------IV TVEPRRRKFHR-------PIGLR--IPLPPSWTDNPRDSGEGDTT------SLRLLCSVI----GGTDQA---QWEDITG TTKLVYANECANFTTNVSA-RFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM-NDPREGRLRCYCMTDDKV-D KTLEQH-ENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQ-RSFHFQSFRENRLAIPVKVRD---SSREPGGSLSF LRKAMK---YEDTQHILCHLNITMP------------------PCSKGSGAEDRRRTPTPLALRY--------------- ----SILSESTPGLLSGTDQAEK-MAVISEHLGLSWA------------------------------------------- -----------------------------------------------ELARELQFSVEDINRIRVENPNSLLEQSVALLN LWVIREGQNTDMENLCTALQ-----SIDRGEIVNMLEG---SGRQSRNLKPDRRHTDRDYS-LSPSQMNGYSSLQDELLS PASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSK-AEDSDATGHEWKL EGALSEEPRGPE-LGSLELVED---DTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQD------------- -----------------------------------------SENEVSLVSGHQRGQARLYHSPTARDQVSKRSET----- -------------------------DGLQDWDPDGSIVS------YLQDAAQGSWREEVTQDPHLFQRTSTTTEGLEPSG SQESEN-------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----VLVSVSEHTRTEQPEAESSQADRDQRQQGQGEQVQEARNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKII 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