>Homo_sapiens_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITNILLRIQSSK- --------------------------------------------------------------------------GFDVK- ----------------------------------------DHAQKQETANSLPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDTKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCNITYIPKDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIKEAYSGCSGPVDSECPPPPSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKAELEKKLSSERPSSDGEGVVENGIT---TCNGKEQ VKR----------------------------------------------------------------------KKSSKSE AK-GTVSKVTGKKITKIISLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNS------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPEALH-----------------YDYIDVEMSASVI QTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGS--------------------------------- ----------WEPEDGFPASCSRGLGEEVLYDNAGLYDNLPPPHIFARYSPADRKASRLSADKLSSNHYKYPASA----- ------------------QSVTNTSSVGRASLGLNS-QLKGKKPPVASNGVTGKGKTLSSQPKKADPAAVVK-------- ------------------------RTGSNAAQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQTKEE ELLKRKEALRNRLAQLRKERKDLRAAIEVNAG----RKPQAI---------LEEKLKQLEEECRQKEAE----------- --------------------------------------------RVSLELELTEVKESLKKA------------------ ------------------------LAGGVTLGLAIEPKSGTSSPQSPVFRHR---------------------------- TLENSPISSCDTSDTEGP---------VPVNSAAVLKKSQAAPGSSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Pan_troglodytes_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITNILLRIQSSK- --------------------------------------------------------------------------GFDVK- ----------------------------------------DHAQKQETANSLPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDTKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCNITYIPKDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIKEAYSGCSGPVDSECPPPPSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKAELEKKLSSERPSSDGEGVVENGIT---TCNGKEQ VKR----------------------------------------------------------------------KKSSKSE AK-GTVSKVTGKKITKIISLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNS------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPG-------------LDCKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPEALH-----------------YDYIDVEMSASVI QTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGS--------------------------------- ----------WEPEDGFPASCSRGLGEEVLYDNAGLYDNLPPPHIFARYSPADRKASRLSADKLSSNHYKYPASA----- ------------------QSVTNTSSVGRASLGLNS-QLKGKKPPVASNGVTGKGKTLSSQPKKADPAAVVK-------- ------------------------RMGSNAAQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQTKEE ELLKRKEALRNRLAQLRKERKDLRAAIEVNAG----RKPQAI---------LEEKLKQLEEECRQKEAE----------- --------------------------------------------RVSLELELTEVKESLKKA------------------ ------------------------LAGGVTLGLAIEPKSGTSSPQSPVFRHR---------------------------- TLENSPISSCDTSDTEGP---------VPVNSAAVLKKSQAAPGSSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Gorilla_gorilla_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITNILLRIQSSK- --------------------------------------------------------------------------GFDVK- ----------------------------------------DHAQKQETANSLPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDTKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCNITYIPKDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIKEAYSGCSGPVDSECPPPPSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKAELEKKLSSERPSSDGEGVVENGIT---TCNGKEQ VKR----------------------------------------------------------------------KKSSKSE AK-GTVSKVTGKKITKIISLGKKKP----STDEQTSSAEEDVP-------------------TC---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------FMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGS--------------------------------- ----------WEPEDGFPASCSRGLGEEVLYDNAGLYDNLPPPHIFARYSPADRKASRLSADKLSSNHYKYPASA----- ------------------QSVTNTSSVGRASLGLNS-QLKGKKPPVASNGVTGKGKALSSQPKKADPAAGVK-------- ------------------------RTGSNAAQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQTKEE ELLKRKEALRNRLAQLRKERKDLRAAIEVNAG----RKPQAI---------LEEKLKQLEEECRQKEAE----------- --------------------------------------------RVSLELELTEVKESLKKA------------------ ------------------------LAGGVTLGLAIEPKSGTSSPQSPVFRHR---------------------------- TLENSPISSCDTSDTEGP---------VPVNSAAVLKKSQAAPGSSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Pongo_abelii_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITNILLRIQSSK- --------------------------------------------------------------------------GLDVK- ----------------------------------------DHAQKQETANSLPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDTKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCNITYIPKDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIKEAYSGCSGPVDSECPPPPSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKAELEKKLSSERPSSDGEGVVENGIT---TCNGKEQ VKR----------------------------------------------------------------------KKSSKSE AK-GTVSKVTGKKITKIISLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNS------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPEALH-----------------YDYIDVEMSASVI QTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGS--------------------------------- ----------WEPEDSFPASCSRGLGEEVLYDNAGLYDNLPPPHIFARYSSADRKASRLSADKLSSNHYKYPASA----- ------------------QSVTNTSSVGRASLGLNS-QLKGKKPPMASNGVTGKGKTLSSQPKKADPAAGVK-------- ------------------------RTGSNAAQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQTKEE ELLKRKEALRNRLAQLRKERKDLRAAIEVNAG----RKPQAI---------LEEKLKQLEEECRQKEAE----------- --------------------------------------------RVSLELELTEVKESLKKA------------------ ------------------------LAGGVTLGLAIEPKSGTSSPQSPVFRHR---------------------------- TLENSPISSCDTSDTEGP---------VPVNSAAVLKKSQAAPGSSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Macaca_mulatta_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MRALAADLR------K-------------VASKR------------ -------------------------------------------------------------------------------- ---------------------RHELAR---------ASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPGALH-----------------YDYIDVEMSASVI QTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGS--------------------------------- ----------WEPEDGFPASCSRGLGEEVLYDNAGLYDNLPPPQIFARYSSADRKASRLSADKLSSNHYKYPASA----- ------------------QSVTNTSSVGRASLGLNS-QLKGKKPPVASNGVTGKGKTLSSQPKKADPAAGVK-------- ------------------------RTASNAAQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQTKEE ELLKRKEVLRNRLAQLRKERKDLRAAIEVNAG----RKPQAI---------LEEKLKQLEEECRQKEAE----------- --------------------------------------------RVSLELELTEVKESLKKA------------------ ------------------------LAGGVTLGLAIEPKSGTSNPQSPVFRHR---------------------------- TLENSPISSCDTSDTEGP---------VPVNSAAVLKKSQVAPGSSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Callithrix_jacchus_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITNILLRIQSSK- --------------------------------------------------------------------------GFDVK- ----------------------------------------DHAQKPETANSLPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWSK------- -------------------------LLCVIKDTKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCNITYIPKDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIKEAYSGCSGPVDSECLPPPSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKADLEKKLSSERPSSDGEGVVENGIT---TCNGKEQ VKR----------------------------------------------------------------------KKSSKSE AK-GTVSKVTGKKITKIISLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNS------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPGALH-----------------YDYIDVEMSANVI QTAKQTFCFMNRRVLSANPYLGGTSNGYAHPSGTALHYDDVPCINGS--------------------------------- ----------WEPEDGFPASCSRGLGEAVLYDNASLYDNLPSPKIFARYSPADRKASRLSADKLSSNHYKYPASA----- ------------------QSLTNTSSVGRASLGLSS-QLKGKKPPVASNGVTGKGKTLSSQPKKVDPVAGVK-------- ------------------------RTASNAAQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADARRLQTREE ELLKRKEALRDRLAQLRRERKDLRAAMDSSAG----RKPQAV---------LEEKLKQLEEECRQKEAE----------- --------------------------------------------RVSLELELTEVKESLKKA------------------ ------------------------LAGGVTLGLAIEPKSGTSSPQSPVFRHR---------------------------- TLENSPISSCDTSDTEGP---------VPVNSAAVLKKSQAAPGSSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Mus_musculus_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVLTNILLRLQSSK- --------------------------------------------------------------------------GFEVK- ----------------------------------------DHAQKAEANN-LPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDTKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCSITYIPRDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIKEAYSGCSGPVDPECSPPPSTSA---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVNKAELEKKLSSERPSSDGEGGVENGVT---TCNGKEQ AKR----------------------------------------------------------------------KKPSKSE AK-GTVSKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNS------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDSKLILHKDRADLKTHLVSIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPGALH-----------------YDYIDVEMSANVI QTAKQTFCFMNRRAVSTSPYLGSLSNGYAHPSGTALHYDDVPCVNG---------------------------------- -------------------------------------------------------------------------------- -------------------------------------SLKNKKPPASSNGVPVKGKAPSSQQKKVETAGGVK-------- ------------------------RTASNAEQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQSKEE ELLKRKEALRNRLAQLRKERKDLRAAIEVNAG----RKTQAA---------LEDKLKRLEEECKQREAE----------- --------------------------------------------RVSLELELTEVKESLKKA------------------ ------------------------LAGGVTLGLAIEPRSGTSSPQSPVFRHR---------------------------- TLENSPISSCDTSDAEGP---------LPVNSAAVLKKSQPSSGSSPCRGHVLQKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Rattus_norvegicus_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVLTNILLRMQSSK- --------------------------------------------------------------------------GFEVK- ----------------------------------------DHAQKAETNN-LPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSEAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDTKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCSITYIPRDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIKEAYSGCSGPVDPECSPPPSASV---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVNKAELEKKLSSERPSSDGEGVVENGVT---TCNGKEQ AKR----------------------------------------------------------------------KKPSKSE AK-GTVSKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNS------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDSKLILHKDRADLKTHIVSIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPGALH-----------------YDYIDVEMSANVI QTAKQTFCFMNRRAVSTSPYLGSLSNGYAHPSGTALHYDDVPCVNG---------------------------------- -------------------------------------------------------------------------------- -------------------------------------SLKNKKPPASSNGLPVKGKAPSSQQKKVESAGGVK-------- ------------------------RTASNAEQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQSKEE ELLKRKEALRNRLAQLRKERKDLRAAIEVNAG----RKTQVA---------LEDKLKRLEEECKQREAE----------- --------------------------------------------RVSLELELTEVKESLKKA------------------ ------------------------LAGGVTLGLAIEPKSGTSSPQSPVFRHR---------------------------- TLENSPISSCDTSDAEGP---------LPVNSAAVLKKSQPSSSSSPCRGHVLQKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Oryctolagus_cuniculus_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------LQC---------------YKSSKD---------------------- ----------------QQPQMELALQGCSVTYTPKDSKKKKHELK-------------------ITQQGTDPLVLAVQSR EQAEQ----------------WLK---------------------VIKEAHG-----VVPECPPPSSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKAELEKKLSSERPSSDGEGAVENGAT---MCNGREQ VKR----------------------------------------------------------------------KKSAKSE AK-GTVPKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNS------- -------------------------------------------------------------------RWRERWC------ -----------------RVRDSKLVLHKDRADLKTHIASIPLRGCEVTPG-------------LDAKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEAASSEDMG------------------------------------ ---------------RWIGILLAETG---------------SPADPAALH-----------------YDYIDVETSASVI QTAKQTFCFMNRRVVSTNPYLGSTSNGYAHPSATALHYDDVPCING---------------------------------- -------------------------------------------------------------------------------- -------------------------------------SFKGKKPPAASTGVPGKGKAGSGQQKRAESAAGVR-------- ------------------------RTASNADQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQSKEE ELVRRKEALRTRLAQLRQERRDLRAAIEANAG----RQTQVL---------LEDKLKKLEEECKQKEAE----------- --------------------------------------------RVNLELELTEVKESLRTA------------------ ------------------------LAGGLTLGLAIEPKSGTSSPQSPGLRHR---------------------------- TLENSPISSCDTSDTEGP---------LPVNSAAVLKKSQPAAGSSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Canis_familiaris_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITDILLRIQSSK- --------------------------------------------------------------------------GFEVK- ----------------------------------------DHAQKQETPNSLPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWSK------- -------------------------LLCVVKDTKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCNVTYTPKDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIRDVYSGCSGPADSEGPPPSSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKTELEKKLSSERPSSDGEGVTENGIT---VCNGKEQ VKR----------------------------------------------------------------------KKSSKSE AK-GTVSKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKTHIVSIPLRGCDVIPG-------------LDSRHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPGALH-----------------YDYIDVETSANVI QTAKQTFCFMNRRGISANPYLGSTTNGYAHPSGMALHYDDVPCINGS--------------------------------- ----------WDPEDGPPASCARGLGEEVLYDNAVLYDNLPSPKIFARYPPADRKASRPSPDKLSCNHYKCPPSCGLPLI ------------------QSATNPSSLGRASLGLSSQNYLNRGPPARRSHQPCSRETQSACPSEARSMAYVK-------- ------------------------RTSSNADQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQSKED ELLKRKETLRNRLAQLRKERRDLRAAIEVNAG----RKTQVV---------LEDKLKRLEEECKQKEAE----------- --------------------------------------------RVNLELELTEVTESLKKA------------------ ------------------------LAGGVTLGLAIEPRSGTSSPQSPVFRHR---------------------------- TLESSPMSSCETSDAEGP---------VPVNSAAVLRKGQP-ASGSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Felis_catus_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITDILLRIQSSK- --------------------------------------------------------------------------GFEVK- ----------------------------------------DHVQKQETPNSLPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDGGPPPLPTSSLP-EAYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGQKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWSK------- -------------------------LLCVIKDTKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCSVTYIPKDSKKKKHELK-------------------IAQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIREVYSGCSGPADSEGPPPSSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKTELEKKLSSERPSSDGEGATENGIT---VCNGKEQ VKR----------------------------------------------------------------------KKSSKSE TK-GTVSKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNS------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKTHIVSIPLRGCDVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWLGILLAETG---------------SSTDPGALH-----------------YDYIDVETSANVI QTAKQTFCFMNRRGVSTNPYLGSTSNGYAHPSGTALHYDDVPCINGS--------------------------------- ----------LK-------------------------------------------------------------------- ----------------------------------------GKKPPAASSGAPGKGKTPSSQQKQADSASSVK-------- ------------------------RTPSNADQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKLLQSKQE ELLKRKETLRNRLAQLRKERKDLRAAIEVNAG----RKPQAV---------LEGKLKRLEEECKQKEAE----------- --------------------------------------------RVNLELELTEVKESLKKA------------------ ------------------------LAGGVTLGLAIEPRSGTSSPQSPVFRHR---------------------------- TLESSPMSSCETSDAEGP---------VPVNSAAVLRKSQP-TGSSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Bos_taurus_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITDILLRIQSSR- --------------------------------------------------------------------------GFEVK- ----------------------------------------DHATKPETPSSLPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PDNGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDTKLLLS------------A-TKSSKD---------------------- ----------------QQPQMELPLQGCNITYIPKDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VVREIYSGCSGPAELECPPPPSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKVELEKKLSSERPSSDGEGVAENGIA---MCNGKEQ VKR----------------------------------------------------------------------KKSSKSE AK-GTVSKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNS------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLILHKDRADLKTHIASIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPGALH-----------------YDYIDVEVSASVI QTAKQTFCFMNRRVLSTNPYVGSTSNGYAHPSGTALHYDDVPCISGSW-------------------------------- -----------GPDDDVPAPRNRGLGEEALYDNAVLYDNLPSPKIFARYPPADRKAARPSPDRLSCNHYKHPASSGLPSS ------------------PSVTNTSSVGRVSLGLSSQ-SKGKKPPVASNGVMGKGKALSGQQKKADSAAGVK-------- ------------------------RTPSNADQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQAKEE ELLRRREGLRDRLAQLRKERKGLRAAIEVNTG----RKTQVV---------LEEKLKKLEEECKQKETE----------- --------------------------------------------RVNLELELTEVKESLKKA------------------ ------------------------LAGGITLGLAIEPRSGTSSPQSPVFRHR---------------------------- TLENSPMSSCETSDAEGP---------LPVNSAAVLKKSRPAPGNSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Equus_caballus_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAAIADILLRVQSAK- --------------------------------------------------------------------------GFEVK- ----------------------------------------DHAQKQETPNSLPAPPQLP---------LPEIPQPWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDAKLLC---------------YKSSKD---------------------- ----------------QQPQMELPLQGCNITYIPKDSKKKKHELK-------------------ITQQGTDPLVLAVQSK EQAEQ----------------WLK---------------------VIREVYSGCSGPADPECPPPSSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKAELEKKLSSERPSSDGEGVIENGIT---MCNGKEQ VKR----------------------------------------------------------------------KKSSKSE AK-GTVSKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLVFHKDRADLKTHIASIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRHGQEVDALEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPGALH-----------------YDYIDVEMSANVI QTAKQTFCFVNRRLLSTNPYLGGTSSGYAHPSGTALHYDDVPCIDGSW-------------------------------- -----------EPDDGFPAPGGRGPGEEVLYDNAVLYDNLPSPKIFARYPPAGRKASRLSTDTLSCNHYKHPTSCSPPSA ------------------QSVTNTSSLGRASLGLNSQ-LRGKKPPLASSGVTGKGKTLSNQQKKADSAASVK-------- ------------------------RTPSNADQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQTKEE ELLKRKEGLRNRLAQLRKERRDLRAAIEVNAG----RKTQVI---------LEDKLKRLEEECKQKETE----------- --------------------------------------------RVNLELELTEVKESLKKA------------------ ------------------------LAGGITLGLAIEPRSGTSSPQ----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Monodelphis_domestica_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAAITNILLRIQSSK- --------------------------------------------------------------------------GFEVK- ----------------------------------------DHVQKQEVTNSLPAPPQMP---------LPEIPQQWLP-- ----------------------------------------------------PDSGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKTRHQWPSDEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDTKLLC---------------YKSSKD---------------------- ----------------QQPHMELPLHGCSITYIPKDSKKKKHELK-------------------ITHQGTDALVLAVQSK EQAEQ----------------WLK---------------------VIREVYNNCSGVVDSDG-PSSSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKTELEKKLSSERPSSDGEGGTENGIT---MCNGKEQ VKR----------------------------------------------------------------------KKSSKSE AK-GTVTKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLTVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKNHIVSIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPGALH-----------------YDYIDVEMTANVI QTAKQTFCFMNRRGISTNPYLGSASNGYAHPSGMALHYDDVPCING---------------------------------- -------------------------------------------------------------------------------- -------------------------------------SFKSKKPPIASNGVPGKGRNANSPQKKTDSSATVK-------- ------------------------RTASNADQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQTKEE DLLRKKETLRNRLAQLRKERKDLRAAIEVNAG----RKTQVI---------LEDKLKKLEEECKQKETE----------- --------------------------------------------RVNLELELTEVKESLKKA------------------ ------------------------LAGGITLGLAIEPKSGTSSPQSPIFRHR---------------------------- TLENSPISSCDTSDTECS---------MPVNSAAVLKRHPQTSGNSPCRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Gallus_gallus_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITNILLRIQSSK- --------------------------------------------------------------------------GFEIK- ----------------------------------------EHVQKPEVANSLPAPPQMP---------LPEIPQQWLP-- ----------------------------------------------------PDNGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKMRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKENKLLC---------------YKSSKD---------------------- ----------------QQPQMELLLNDCSITYIPKDSKKKKHELK-------------------ISHQGADALVLAVQSK EQAEQ----------------WLK---------------------VIKDVCSNCTGTVDSDG-PLSSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKTELEKKLSSERPSSDGEGAVENGITT--VCNGKEQ VKR----------------------------------------------------------------------KKSSKTE AK-GTVTKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGMLLAETG---------------SSTDPGALH-----------------YDYIDVEMTASVI QAAKQTFCFMNRRVISTNPYRGSTANGYACPSGMALHYDDVPCINGS--------------------------------- ----------WEPEDGFPSSRSRNMGEEMLYDNAGLYDNLPSPKIFARYPPADRKTNRLSTDKLSSNHYKHPVSSNLSSA ------------------QSVTNTSAVGRGSVS----QFKGKKPPATANGITGKVRTLNSQPKKPESVSCVK-------- ------------------------RTASNAEQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQSKEE ELLKRKEALRNRLAQLRKERKDLRAAIEVNAG----RKTQVI---------LEDKLKKLEEECKTKEAE----------- --------------------------------------------RVNLELELTEVKESLKKA------------------ ------------------------LAGGITLGLAIEPKSGTSSPQSPIFKHR---------------------------- TLENSPISSCDTSDTECS---------IPVNSAAALKR-PPSSNNSPCRGHVLRKAK---EWEMKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Taeniopygia_guttata_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLE-LLDHEYLTSTVREKKAVITNILLRIQSSK- --------------------------------------------------------------------------GLEIK- ----------------------------------------EHVQKQEVANSLPAPPQMP---------LPEIPQQWLP-- ----------------------------------------------------PDNGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGKKMRHQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKENKLLC---------------YKSSKD---------------------- ----------------QQPQMELLLNDCSITYIPKDSKKKKHELK-------------------ISHQGADALVLAVQSK EQAEQ----------------WLK---------------------VIKDVCSNCTGAVDSDG-PLSSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVHKVELEKKLSFERPSSDGEGAVENGITT--VCNGKEQ VKR----------------------------------------------------------------------KKSSKTE AK-GTVTKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKTHIVSIPLRGCEVILG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEDMG------------------------------------ ---------------RWIGILLAETG---------------SSTDPGALH-----------------YDYIDVEMTASVI QAAKQTFCFMNRRGISTNPYRGSAANGYACPSGMALHYDDVPCINGS--------------------------------- ----------WEPEDGFPSSRSRSMGEEMLYDNAGLYDNLPSPKIFARYPPADRKANRLSTDKLSSNHYKYPVSSNLSSA ------------------QSVTNTSAVGRGSGS----QFKGKKPPVTTNGIAGKARTLNSQPKKSETVSCVK-------- ------------------------RTASNAEQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQSKEE ELLKKKEALRNRLAQLRKERKDLRAAIEVNAG----RKTQVI---------LEDKLKKLEEECKQKEAE----------- --------------------------------------------RVNLELELTEVKESLKKA------------------ ------------------------LAGGITLGLAIEPKSGTSSPQSPIFKHR---------------------------- TLENSPISSCDTSDTECS---------IPVNSAAALKR-PPSSNNSPCRGHVLRKAK---EWEMKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Xenopus_tropicalis_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELIVELRLFLD-LLDHEFLTTTVREKKTLISNILYRIQSAR- --------------------------------------------------------------------------ESELK- ----------------------------------------NHNHRAEMPCSVPAPPQMP---------LPEIPQQWLP-- ----------------------------------------------------PDNGPPPLPTSSLP-EGYYEEAVPLSPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGQKKRLQWPSEEASMDLVKDA-----------KICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDNKLMC---------------YKTSKD---------------------- ----------------QQPQMELPLNGCAVTYVPKDSKKKKHELK-------------------VTHQGTDALVLAVQSE EQAEQ----------------WLR---------------------VIKDACNISGGPIDSDG-PISSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------PVPKSELEKKLSIERPSSDGEGNVENGTVI--TNDKEPV VKR----------------------------------------------------------------------KKSGKVE PK-GTVTKVTGKKITKIIGLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPG-------------LDSKHPL---------- -------------------------------------------------------------------------------- ---------------------TFRLLRNGQEVAVLEASSSEKMG------------------------------------ ---------------RWLGILLAETG---------------SSTDPGALH-----------------YDYIDVDTTANVI QTAKQSFCFMNRRVISANPYREATTNGYSCPSGVALHYDDVPCINGL--------------------------------- ----------WRPDEDYETYRNRKNGEEVHYDDADLYDNLPSPKIFARYPPADTKANRFSTDKLPPNHYKSPVSSSLSS- ------------------QSVTNNSAVGRGPLSSQS-QLKSKKPPAMANGIAAKGRINNSQPKNAAPAANVK-------- ------------------------RTASNAEQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKKLQMKEE ELLRKKEALRNRLAQLRKEKRDIRAAIEANAG----RKSQVL---------LEEKMKKLEDECKQKERE----------- --------------------------------------------RVTLELELTEVKESLKKA------------------ ------------------------MAGGITLGLAIEPKQGSSRSQSPVLKHR---------------------------- TVENSPISSCDTSDAECS---------LPVNSAAALKR-QPSASNSPVRGHVLRKAK---EWELKNGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Danio_rerio_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELLAELRVFLE-LLDREYLTAGVREKKQQILNILHRVLATR- --------------------------------------------------------------------------GFVLS- ----------------------------------------EPSCKTEIHTSLPAPPQMP---------LPEIPHPWMP-- ----------------------------------------------------PDNGPPPLPSSSLP-EGYYEEAVPLGPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGQKMRHQWPSEEASMDLVKDA-----------RICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDNKLLC---------------YKSSKD---------------------- ----------------QTPQMELLLSGCSITHIPKDGKKKKHELK-------------------IVHQGADALVLAVQSK EQAEQ----------------WLK---------------------VMKEVCSNGNGVVDCDGAGSGST------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------VHKAELEKKLSCDRPSSDGEPCHENGISD-----GKDP AKG----------------------------------------------------------------------KKNSKSE QK-GTVGRVTGKKITKIISLGKKKP----STDEQTSSAEEDVP-------------------TCGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------QLKDNQLFLHKDRADLKTHMASLPLRGCEVIPG-------------LDSKHPF---------- -------------------------------------------------------------------------------- ---------------------AFRLLRNGQEVAVLEASSSESMG------------------------------------ ---------------RWLGVLLAETG---------------STTDPAALH-----------------YDYIDVETTANVI QLAKQSFCFTSKRAVSPNPYLDNPVNGYACPTGVALHYDDVPCINGTIP------------------------------- -----------DAHYSSPASGGRRWKDESHYENTDLYENMPSPKLAARYSPKSTRTSSSS------GHYSTPNSTKSLSS ------------------SSAANTNTNQSS------NQMKGKKGL-ITNGFG-AKKLDKNQPKKANGISSTLP------- ----------------------VKRNNSSVDQY----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKKLQAKEE ELMRKKQEIRNRLTQLKKDRKDLRTALENNTA----KRSQAS---------LTERLKKVEDECKLKEEE----------- --------------------------------------------RVSLELELTEVKESLKKA------------------ ------------------------LNGGVTLGLTIEPKTGSSSPQSPVLMRR---------------------------- TVDNSPISSCNTSDTETCS--------LPVNSASLLRRQT-QQKASPVRGHVLRKAK---EWEMKSGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Takifugu_rubripes_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELLCELRLFLD-LLDREYLSAGVRERKLHLSNILHRVLSER- --------------------------------------------------------------------------VGSHPS --------------------------------------VLEPSFKPETPSGLPAPPQMP---------LPEIPQPWLP-- ----------------------------------------------------PNSGPPPLPSSSLP-EGYYEEAVPLGPG KAPEYITSH------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGQKMRHQWPSEEASMDLVKDA-----------RICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDNKLLC---------------YKSSKD---------------------- ----------------HTPQMELILSGCSVTHVPKDGKKKKHELK-------------------IVHQGADPLVLAVQSK EQAEE----------------WLK---------------------VMKEVCVNGN--VDLDRVGSGSP------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------VHKPELEKKASCDRPSSDGELTHENGHSD-----CKDQ GKG----------------------------------------------------------------------KKSSKSE QKSGTVGKGAGKTITKIIGLGKKKP----SVDEQTSSAEEDVP-------------------TCGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RLKDNQLLLHKDRDDLKSHIASLPLRGCEVSPG-------------LDHKHPF---------- -------------------------------------------------------------------------------- ---------------------AFRLLRNGQEVAVLEASSSEAMG------------------------------------ ---------------RWLGVLLAETG---------------STTDPATLH-----------------YDYIDVETTANII QLAKQSFCFTSKRAVSPNPYLDNPVNGYACPTGMALHYDDVP-INGTNL------------------------------- -----------EALNSSSNTGGRQLKEPLHYENTDVYENVPSPELAARCPAKPPPSSSSSS-VCSNSHYKTPQGSKVSSK ------------------FLSEDTKVKNAVSS----NQVKGSKG--LTNGLSWKQKVDPKKQVKKSAVNVMN-------- ---------------------------ADADQC----------------------------------------------- -------------------------------------------------------------KYGKNRVEADARRLQCKEE ELMKRKQEIRSHLSQLKKDRRDMKAALETSTG----KRSHAL---------LAERLKKTEEECKQKEEE----------- --------------------------------------------CVNLELELTEVKENLKKA------------------ ------------------------LSGGVTLGLTIQPKSGSSGLQSPAVSRR---------------------------- TLESSPFSSCDTSDTESCS--------LPVNSASLLRRQPPGQKPSAVRGHVLRKAK---EWEQSTAH------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Tetraodon_nigroviridis_AFAP1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------PDSAAPPLPSSSLP-EGYYEEAVPLGPG KAPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEDED-GKGQKMRHQWPSEEASMDLVKDA-----------RICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKEQKLLC---------------YKSSKD---------------------- ----------------HAPQMELTLSGCSVTHVPKDGKKKKHELR-------------------IVHQGADPLVLALQSQ EQAEE----------------WLK---------------------VMREVCVSGN--VDLDGAGSGSP------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------VHRTELEKRTSCDRPSSDVEPTLENGHSD-----WKDP GKG----------------------------------------------------------------------KKSSKPE QKGGTVGRGAGRTITKIIGLGKKKP----SVDEQTSSAEEDVP-------------------VCGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RLRDNQLLLHKDRDDLRGHMASLPLRGCEVNPG-------------LDHKHPF---------- -------------------------------------------------------------------------------- ---------------------AFRLLRNGQEVAVLEASSSEAMG------------------------------------ ---------------RWLGVLLAETG---------------CTTDPAALH-----------------YDYMDVETTANIV QLAKQSFCFTSRRAVSPNPQLDNPVNGYACPTGTALHYHDVA-INGT--------------------------------- -------------------------------------------------------------------------------- --------------------------------------LKGSKG--CANGFPWKQKLDPRQQGKGGVASAPS-------- --------------------------SSEAERC----------------------------------------------- -------------------------------------------------------------RYGKNRVEADARRLQAQEE ALSRRKQELQAQLGQLKKERRELRAALEASSG----KRGQAS---------LTERLKKTEEECRRKEEE----------- --------------------------------------------RVNLELELTEAKENRKKA------------------ ------------------------QSAGVTLGL----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Gasterosteus_aculeatus_AFAP1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MEELVCELRLFLD-LLDREYLSAGIREKKMHLSNILNRVLSDK- --------------------------------------------------------------------------GEQKK- ----------------------------------------EPSFKLDIHSGLPAPPQMP---------LPEIPHPWLP-- ----------------------------------------------------P-TGPPPLPSSSLP-EGYYEEAVPLSPG KAPEYITAN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGQKMRHQWPSAEASMDLVKDA-----------RICAFLLRKKRFG-------------QWAK------- -------------------------LLCVIKDNKLLC---------------YKSSKD---------------------- ----------------HTPQMELTLTGCTITHIPKDGKKKKHELK-------------------IIHQGADALVLAVHSK EQAEE----------------WLK---------------------VMREVCVNGG--IDLDRAGSGSP------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------VHKPELEKKSSCDRPSSDGEATHENGQGD--QENSKKS TKG----------------------------------------------------------------------KKNTKSE QKTGTVGKGAGKKITKIIGLGKKKP----STEEQTSSAEEEVP-------------------LCGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RLKDNQLLLHKDRDDLKSHIASLPLRGCEVSPG-------------LDHKHPF---------- -------------------------------------------------------------------------------- ---------------------AFRLLRNGQEVAVLEASSSEEMG------------------------------------ ---------------RWLGILLAETG---------------STTDPATLH-----------------YDYIDVETTANVI QLAKQSFCFTSKRAVSLNPYLDNPVNGYACPTGMALHYDDVP-INGTDP------------------------------- -----------GVQYSSPNTRGGQLNEEVHYENAELYENMPSSKLDICYPPKLSSSSSSS-----ASHYKSP-VSKVSSK ------------------FLAADTKTKATAQGRGPIEQLKGKKGT-ATNGMASKQKTEPKNQTKKNGVNGTNGTAS---- ----------------------LKRNDSNAEQC----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQVKEE ELMKKKQEIRTHLTYLKKERRDLRTAVEAAAG----KRSHAS---------LSERLNKVEEDCRQKEQE----------- --------------------------------------------RVNMELEMTEVKESLKKA------------------ ------------------------LSGGVTLGLTIEPKAGSSGIQQRCDGPR---------------------------- SLH--PFSSC--SDTESCS--------LPVNSASLLRRQQGGQKASPVRGHVLRKAK---EWEQKTGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Oryzias_latipes_AFAP1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------PSSGPPPLPSSSLP-EGYYEEAVPLSPG KTPEYITSN------------------------------------------------------------YDSDAMSSSYE SYDEEEED-GKGRKMHHQWPSEEASMDLVKDA-----------LICAFLLRKKRFG-------------QWTK------- -------------------------LLCVIKDNKLLC---------------YKSSKD---------------------- ----------------QTPQMELILSGCSIIHVPKDGKKKKHELK-------------------IVHQGADALVLAVQSK EQAEE----------------WLK---------------------VMREVCVSGS--ADIDGAGSG-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------LPELEKRTPCDRPNSDGEAAHENGHSE--WRDPGGQ SKA----------------------------------------------------------------------KKNSKSD PKTGTVGKGAGKKITKIIGLGKKKP----SMDEQTSSTEEDVP-------------------TSGYLNVLSNN------- -------------------------------------------------------------------RWRERWC------ -----------------RLKDSQLLLHKDRDDLKSHIASLPLQGCEVSPG-------------YNPKHRF---------- -------------------------------------------------------------------------------- ---------------------AFRLLRNGQEVAVLEASSSEEMG------------------------------------ ---------------HWLGVLLAETG---------------STTDPATLH-----------------YDYIDVETTANVI QLAKQSFCFTSKRAISPNPYLDNPANSYACPSGLALHYDDVP-INGMGFKWL---------------------------- ---------IKDVFLLSLIFRGHRTNEQPPNGNADLYENVPSSEPTTCHRLQPSSAFSSS----TAAHYKTPLKNSIPTK ------------------QSQVGRGAAVGRSS---HDRVKGKKGL-AANRVTSKLKPEPKN--KKNGVLGANGTSP---- ----------------------VKRNNSNAEQC----------------------------------------------- -------------------------------------------------------------KYGKNRVEADAKRLQTKEE ELLKKKELIKNHLTQLKKERKDLRSAVEAVGG----KPAQAS---------LSEQLKKLEDECKKKENE----------- --------------------------------------------RVNLELELTEVKESLKKA------------------ ------------------------LSGGVSLGLTIEPKAASSSVQSPATVRQ---------------------------- TQESSTLSSCDTSDTESCS--------LPVNSAALFRLQQNDQKPLTIQGHVLRRAK---EWEQKSGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Oryzias_latipes_AFAP1b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------ELVIHEQLAKQLINHFY-FMATIWLEKKGLLSKSTVW----------- --------------------------------------------------------------CAVSN-SFFTKIHSETF- ---------------------------------------HTLHQLPAPPGYPFFTTP---------------TPRFTT-- ----------------------------------------------------PTDTPPPLPTTPLP-DDYYEEAVPLDPG SSPQYFTTTVN---------------------------------------------------------YNDSDALSSSYE SYEEEE-EEPKGQDLSQKWTSEQNMDGPVKEC-----------HICAFLLRKKRFG-------------QWAK------- -------------------------QLVVIRDNKLQ--------------C-YKSIKD---------------------- ----------------TSPHTELPLNLCNVIYVPKEGKKKRHELR-------------------FSLPGGDALVLAVQSK EQAQR----------------WLK---------------------VVHDVGIQFNHSEGPNGSTSPIIQ----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------RKLELDKMLQSDKQASDSKE--VFSNG---LLLCCDK -NPIGR-------------------------------------------------------------------GKRGAFS ELTGSMSRAAGKKINRIITFSKKKNAL--PGEAPLSSGSADNP-------------------RCGHLSVCLSG------- -------------------------------------------------------------------AWKERWC------ -----------------VLRGGNLYLQKDPADQRPPVIVVPLKRAEVVPGG------------LGPKHPF---------- -------------------------------------------------------------------------------- ---------------------SFRIMQGGNELASLEASCSEDLG------------------------------------ ---------------RWLGILFAETG---------------SPALPVELH-----------------YDYIDVDTLTDIR HAARQSFLWATTTCIDSR------------TYER-SKQNPYKHSEKYAIILL---------------------------- -------------------------------------------------------------------------------- --------------------------YCICVGNCCHTVVQDEDAEGKSSQVRRHASFSSRDSERTEQQATIK-------- ------------------------RHTSNVVQYG---------------------------------------------- -------------------------------------------------------------RYGKTRAEEDAKRYLRQKE ELEKQKQELRNTLISLRKEKKVLKEEVKS--------GPGHD---------AEKRLAQLETLCKDKEEE----------- --------------------------------------------RVELELRLTEVKENLKKS------------------ ------------------------LARGALAPPNNKDNCPKLLEILL--------------------------------- -QKTTADEGDTVVNKKIES--------VPVNAASELRKRPPSFYAS-SKGSVMQKAK---EWESKKGT------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Branchiostoma_floridae_AFAP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MDKLQALEELLPGIQEYLCHQLSGEKLSRSAANQRLEFVKLLDKYKADTK TVPSIEA--------------------------------------------QEDEMYEDTLVPDKPPSSFLHQNGSGPSL VE----------------------------------DVNGDEYYEDTLPSSTNGSARPDSFIERQKIPLPPIPGQGGEQD EEE------------------------------------------YECPMAAPAQDGPPLPPRFPPTPAPTVALPPRPAA PLPTPQTEQAP------------------------------EAISEDTYEVPDVDPPAMGRMSVMSTPGGDSGDESGSYE DYDDDEED--TKKKEKRKKKESKPEVFELPDA-----------QISGVLQNKRLIG-------------GWVK------- -------------------------RFCAVKDSRFLA---------------YKRATD---------------------- ----------------EKPYVDMYLPGSSVVYSEKEGK-KQHVVK-------------------LVG-GGDTHVLSVGNK AEADR----------------WIK--------------------LLEEETQSGSGGMLAPGRAKVGRTP----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------SNVSDISRGSNSSRENEDVQDGNDSGKGG--TLERQED KRK------------------------------------------------------------