>Homo_sapiens_ADAMTS1 -------------------------------------------------------------------------------- ------------------------------------------------------------------------MQRAVPEG FGRRKLGSDMGNAERAPGSRSFGPVPT------------------LLLLAAALLAVSDALGRPSEEDEELVVPE------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------LERA----PGHG------------TTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPET --------------------------DLAHCFYSGTVNGDPSSAAALSLCEG-VRG--------------AFYLLGEAYF IQPLP-AASERLATAAP---------------GEKPPAPLQFHLLRRNRQGDVG-------------------------- -----------------GTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQ--------WSPQDPALQGVGQPTGTGSIRK KRFVS--------------------------------------SHRYVETM-LVADQSMAEFHG--SGLKHYLLTLFSVA AR-------------------------------LYKHPS--IRNSVSLVVVKILVIHDEQ-----KGPEVTSNAALTLRN FCNWQKQHNP-PSDRDA----------EHYDTAILFTR-----QDLCGSQT---CDTLG-MADVGTVCDPSRSCSVIEDD GLQAAFTTAHELG-HVFNMPHDDAKQCASLNGVNQDS---HMMASMLSNLDHS-QPWSPCSAYMITSFLDNGHG--ECLM DKPQNPI----QLPG----DLPGT--SYDANRQCQFTFGED---------------SKHCPD------------------ ------------------------------------------------------------------AASTCSTLWCTGTS G-GVLVCQTKH--FPWADGTSCGEGK----WCINGKCVNKT-DRKHFDT---PFHGSWGM------WGPWGDCSRTCGGG VQYTMRECDNPV---------------PKNGGKYCEGKRVRYRSCNLED----CPDNN---GKTFREEQCEAHNEFS-KA SFGSGPAVEWIPKYAGVSPKDRCK-----LICQAKGIGYFFVLQPKVV------DGTPCSP-------------DSTSVC VQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHD--------------------------IITIP TGATNIEVKQRNQRGSRNNGSFLAIKAAD--GTYILNGDYTLSTLEQDIMYKGVV-LRYSGSSAALERIR--SFSPLKEP LTIQVLTV-----GNALRPKIKYTYFVKK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KKESFNAIPT---------------- -----------FSAWVIEEWGECSKS----CELG-WQRRLVECRDINGQPASECAK------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------EVKPASTRPCADHPCPQ---WQLGEWSSCSKTCGKGYKK-----------RSLKCLSHDGG VLSHESCDPLKKPKHFIDFCTMAECS------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Mus_musculus_ADAMTS1 -------------------------------------------------------------------------------- ------------------------------------------------------------------------MQPKVPLG SRKQKPCSDMGDVQRAARSRGSLSAHMLLL---------------LLASITMLLCARGAHGRPTEEDEELVLPS------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------LERA----PGHDS----------TTTRLRLDAFGQQLHLKLQPDSGFLAPGFTLQTVGRSPGSEAQHLDP T------------------------GDLAHCFYSGTVNGDPGSAAALSLCEG-VRG--------------AFYLQGEEFF IQPAPGVATERLAPAVP---------------EEESSARPQFHILRRRRRGSGG-------------------------- -----------------AKCGVMDDETLPTSDSRPESQNTRNQ---------------WPVRDPTPQDAGKPSGPGSIRK KRFVS--------------------------------------SPRYVETM-LVADQSMADFHG--SGLKHYLLTLFSVA AR-------------------------------FYKHPS--IRNSISLVVVKILVIYEEQ-----KGPEVTSNAALTLRN FCSWQKQHNS-PSDRDP----------EHYDTAILFTR-----QDLCGSHT---CDTLG-MADVGTVCDPSRSCSVIEDD GLQAAFTTAHELG-HVFNMPHDDAKHCASLNGVSGDS---HLMASMLSSLDHS-QPWSPCSAYMVTSFLDNGHG--ECLM DKPQNPI----KLPS----DLPGT--LYDANRQCQFTFGEE---------------SKHCPD------------------ ------------------------------------------------------------------AASTCTTLWCTGTS G-GLLVCQTKH--FPWADGTSCGEGK----WCVSGKCVNKT-DMKHFAT---PVHGSWGP------WGPWGDCSRTCGGG VQYTMRECDNPV---------------PKNGGKYCEGKRVRYRSCNIED----CPDNN---GKTFREEQCEAHNEFS-KA SFGNEPTVEWTPKYAGVSPKDRCK-----LTCEAKGIGYFFVLQPKVV------DGTPCSP-------------DSTSVC VQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKMSGIVTSTRPGYHD--------------------------IVTIP AGATNIEVKHRNQRGSRNNGSFLAIRAAD--GTYILNGNFTLSTLEQDLTYKGTV-LRYSGSSAALERIR--SFSPLKEP LTIQVLMV-----GHALRPKIKFTYFMKK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KTESFNAIPT---------------- -----------FSEWVIEEWGECSKT----CGSG-WQRRVVQCRDINGHPASECAK------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------EVKPASTRPCADLPCPH---WQVGDWSPCSKTCGKGYKK-----------RTLKCVSHDGG VLSNESCDPLKKPKHYIDFCTLTQCS------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Dasypus_novemcinctus_ADAMTS1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MEAARRPRSSQRALS-RL---------------LLAVAAVLLTVPGTGGRPAQEDEELVLPE------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------LQRA----GEHE------------TTRLLLDAFGRRLLLELQPDHGFLAPGFTLQTVGRSPEPETPRPES S------------------------GDLAHCFYSGTVNGDAHSAAALSLCEG-VRG--------------AFYLQGEEYF IQPAPAAASVRLAP--AAHGE-------------EPPQQPQFHLLRRRRRGGDG-------------------------- -----------------AKCGVMDDEILPPRGAGPE-DGTGEQ---------------WSQRDRAPQSAEQPTGTGSIRK KRFVS--------------------------------------SPRYVETM-LVADQSMADFHG--GGLKHYLLTLFSVA AR-------------------------------LYKHPS--IRNSVSLVVVKILVIYEEQ-----KGPEVTSNAALTLRN FCNWQKQHNP-LSDRDA----------EHYDTAILFTR-----QDLCGAQT---CDTLG-MADVGTVCDPSRSCSVIEDD GLQAAFTTAHELG-HVFNMPHDDAKQCASINGMNRDS---HLMASMLSNLDRS-QPWSPCSASMITSFLDNGHG--ECLM DKPQNPI----QLPS----DLPGT--LYDANRQCQFTFGEE---------------SKHCPD------------------ ------------------------------------------------------------------TASTCTILWCTGIS G-GLQVCQTKH--FPWADGTTCGEGK----WCVGGNCVNKT-DRKHFDI---PVHGSWGP------WGPWGDCSRTCGGG IQYTMRECDNPV---------------PKNGGKYCEGKRVRYRSCNIED----CPDNN---GKTFREEQCEAHNDFS-KA SFGTGPAVEWTPKYAGVSPKDRCK-----LICQAKGIGYFFVLQPKVV------DGTPCSP-------------DSTSVC VQGQCVKAGCDRIIDSKKKFDKCGICGGNGSTCKKISGSVTSAKPGYHD--------------------------VITIP TGATNIEVKHRNQRGSRNNGSFLAIRAAD--GTYILNGDFTLSTLEQDITYKGSV-LRYSGSSAALERIR--SFSPLQEP LTIQVLTV-----GNALRPKIKYTYFVKK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KKESFNAIPT---------------- -----------FSEWVIEEWGECSKS----CGSG-WQRRLVECRDINGQPASECAK------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------EVKPASTRPCAEGPCPH---WQLGDWSPCSKTCGKGYRK-----------RTSKCVSHEGA VLSQESCDLLKKPKHYIDFCTMAECS------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Gallus_gallus_ADAMTS1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------IRNWK---------------LPFICSQYCGRKMYXQRP-AARQALVLPR------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------RLG-----------SAG------GRERFRLEAFGERLTLELEPDSSFLAPDFTLQYLGG-PPPPSSSSPP PGD-----------------------DLARCFYSGTVNRDPGSAAALSLCAG-MRG--------------AFSLRGREYL IQPAPG--------------------------AAAHRLGPHLLRVRG-PRAPAA-------------------------- -----------------SRCAVTEQGEK-RGRGGGARAG--------------------AGALG--------AQTRSKRK KRFVS--------------------------------------SPRYVETM-LVADQSMAEFHG--SGLKHYLLTLLSVA AK-------------------------------LYKHPS--IRNSISLVVVKIMVIYEER-----KGPDISSNAALTLRN FCSWQKQHNP-PSDRHA----------EHYDTAILFTR-----QDLCGAKT---CDTLG-MADVGTVCDLNRSCSIIEDD GLQAAFTTAHELG-HVFNMPHDDAKQCAGINGISRDF---HMMASMLSNLDRS-QPWSPCSAYMITTFLDNGHG--ECLL DKPHRPI----QLPS----DLPGT--LYDANRQCQFTFGDE---------------SKHCPD------------------ ------------------------------------------------------------------AASTCTTLWCTGTS G-GLLVCQTKH--FPWADGTSCGEGK----WCMNGKCVNKT-EKKHYDT---PVHGSWGS------WGAWGECSRSCGGG VQYSFRECDNPV---------------PRNGGKYCEGKRVQYRSCNIED----CPDNN---GKTFREEQCEKHNEFS-KS TFGSGPAVEWTPKYAGVSPKDRCK-----LVCRAKGTGYFFVLQPKVV------DGTPCSP-------------DSTSVC VQGQCVKAGCDRMIGSNKKFDKCGICGGNGSTCKKVSGTFVRAKPGYHD--------------------------VVTIP AGATNIEVKQRNHRGARHDGSFLAIKAAD--GTYVLNGDYTLSTLEQDITYKGSV-LRYSGSSAALERIR--SFSPLKEP LTIQVLTV-----GDLPQPKIKFTYFVKKPA---QPASEKV--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------PSKKKESFNAIKEI--------------- ----------ISSEWVIEEWGECSKS----CGSG-WQRRAVECRDPRGRPATDCAR------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------ELKPSDIRPCADIPCPQ---WQLGDWSACSKTCGKGFKK-----------RLLKCISYDGG VLPQESCEPSKKPKHLIDFCNVTDCS------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Xenopus_tropicalis_ADAMTS1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------AKMMGYL---------------LPWMAALLCARN-ALGMGTALEEELVAPV------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------RLDP----GTTQGESGN------GKVRYHLNVFGESLTLDLEPDRTFLAPDFSLQYVGS--PAERNGGAE PLA-----------------------ELAKCFYSGSVNGDSTSSAALSLCSG-LRG--------------AFFYRGEEYL IQPSNHT--------------LT---------VADPDSPDPLVLHLVRRRSRAK-------------------------- -----------------AKCGVTDSVGQ-PVKSEDAPSQ--------------------RTMPPTEKKATKKRSGSSRRK KRFVS--------------------------------------SPRYVETM-LVADQSMAEFHG--SSLKHYLLTLMSVA AK-------------------------------LYKHPS--IRNSISIVVVKILVIYDEQ-----KGPDVSSNAALTLRN FCSWQKQHNP-PSDRHA----------EHYDTAILFTR-----QDLCGAQT---CDTLG-MADVGTICDPTRSCSIIEDD GLQAAFTTAHELG-HVFNMPHDEAKQCSGLNRDNQDS---HMMASMLSNLDRY-EPWSPCSAYMITSFLDNGHG--ECLL DKPHRPI----QLPS----DLPGT--LYDANKQCQFTFGDE---------------SRHCPD------------------ ------------------------------------------------------------------AASTCTTLWCTGVS G-GLLVCQTKH--FPWADGTSCGEGK----WCINGKCMDQT-DKKHYET---PVHGGWGA------WGQWGECSRTCDGG VQYSVRECDNPV---------------PKNGGKYCEGKRVQYRSCNIQD----CPENN---GKTYREEQCEAHNDLS-KS PFGSGPAVEWTPKYAGVSPKDRCK-----LMCRAKGTGYFFVLNPKVV------DGTPCSP-------------DSTSMC IQGQCVKAGCDRVIGSSKKFDKCGVCGGNGSTCKKVSGNFIISRPGYQD--------------------------VVTIP AGATNIEVKQRNNRGSRHDGSFLAIKAAD--GNYILNGDYTLSTLEQDIIHNGNI-LRYSGSSASLERIR--SFSPLKEP ITIQVLTV-----GDSHRLKIKYVYFVKKTG---QPEK------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------PNKKKESFNAIRET--------------- ----------ILSEWVIEEWGECSKT----CGLG-WQRRTVECKDINGQPSTDCAN------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------ELKPDDIRPCADTPCPQ---WQLGDWSSCSKTCGKGFKK-----------RLLKCVSYDGV SMPQENCDPLKKPKHLIDFCTLANCS------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Danio_rerio_ADAMTS1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MSFLRVVLSLAGFALCVNAAQ---------------SAWEESFVLPVRLDTQPG------HTKQS------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------REED----SEKR--------------IYRLDVFGKRMVLALEPDQTFLAPGFVFQMVGKPETG----EFD SAG------------------------EARCFFSGTVNGDELSSAAINLCKG-LHG--------------GFSVGGEEYF IQPENS-TGAA--------------------------TDRDTHTIRRRTPGILAEE------------------------ ---------------SGSKCGVNEEEERVTEKPHTTHSKPSES------------------K-------------AHHRS RRFVS--------------------------------------TPRYLEIM-IVADQSMAEFHG--AQLKPYLLTIMAVA SR-------------------------------LYRHPT--IHNSITLAVVKLLVVHDEE-----HGPHVSTNAALTLRS FCQWQKQHNQ-PSDRHP----------EHYDTAVLFTR-----KDLCGAHS---CDTLG-MADVGTACDPDRSCSIIEDD GLQAAFTVAHELG-HVFNMPHDDAKQCASVNGDQWGA---HMMASTLSNLNQL-DPWSPCSALMVTSFLDNGHG--QCLL DKPQKPE----ELPQ----TLPGS--VYDADRQCRLTFGEE---------------SQHCPD------------------ ------------------------------------------------------------------LSSTCAALWCTVTS ANGLLVCQTKN--FPWADGTPCGSNS----YCMAGQCLSKTEAAKY-ET---PVNGGWGS------WGSWGDCSRTCGGG VQYSFRDCVNPR---------------PKNGGKYCEGKRIQYRSCNTET----CPDSN---GLTFREEQCLAHNDLSSQV SLGSGEGVEWVPKYAGVSPKDRCK-----LVCRAKGTGYFFILKPKVA------DGTPCTP-------------DSTSVC VQGQCVKAGCDRVIGSDKRFDKCGICGGDGSTCKKVSGSMERARPGYQD--------------------------VVTIP AGATHLDVKQRSFGGRSQDNSYLAVRRQD--GSYLLNGDYKLTTLETDISVKGAL-LRYSGSSVLLERLR--SFAPLPEP LTIQVLSV-----GESPRPRVKYSYFAPRPN---GSNRPSINAISKAVD------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------AEWFLGEWGTCSKTCGGGIQTRDVMCLDSKRRPSKNCVDELRPAS----------- ---SRQCALQDCPFWFLGEWGTCSKT----CGGG-IQTRDVMCLDHNRRPSKDCVELHPPSSRQCALQDCPAWFLGEWGT CSKTC--------------------------------------------------------------------------- ----------------------------------------------------------------------------GGGI QKRDVMCLDHNHRPSEDCVELRPASSRQCALQDCPF---WLPGNWSECSRTCGRGFRK-----------RTLSCITHDGH ILPNSSCNATDRPRPLLNLCNLTPC------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Takifugu_rubripes_ADAMTS1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MLLLHIFL-GIIASLCVGTAH---------------GAWEESMVVPVRLDPATRPEPWRTFSVEE------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------QQKR----AEMR--------------EYRLEVFGKELVLELEPDQTFLAPGFVFHIVGSPESEPTPE-SK NGA------------------------EPGCFYSGTVNGEEHSAAALNLCHG-LRG--------------GFYFQGVEYF IQPLNSSDFVG--------------------------TEETVHMIRRRARASLAEE------------------------ ---------------GSSKCGVNEDEERVPKNLEKEAGRGAANG---------------DQT-------------AHHRT RRFVS--------------------------------------TPRYLEIM-IVADQSMAEFHG--AGLKPYLLTIMAVA SR-------------------------------LYRHPS--IHNSISLAVVKLLVVYEEE-----YGPQVSSNAAMTLRN FCQWQRQHNP-TSDRHA----------EHYDTAVLFTR-----TDLCGAHS---CDTLG-MADVGTVCDPDRSCSIIEDD GLQAAFTVAHELG-HVFNMPHDDAQLCSEVNGAHWGS---HMMASTLSNLDQQ-QPWSPCSALMVTTFLDNGHG--QCLL DKPVRPQ----ALPQ----PLPGT--VYDADHQCRLTFGED---------------SQHCPD------------------ ------------------------------------------------------------------LSTTCAALWCTVTT SNGLLVCQTKN--FPWADGTPCGHDS----YCLAGQCLTKSQAAKH-QI---PVNGGWGT------WGPWGDCSRTCGGG VQYSFRSCDNPL---------------PRNGGKYCEGKRIQYHSCNTET----CPDTN--AGLTFREEQCLAHNDMSAQV SLGSGEGVEWVPKYAGISPKDRCK-----LVCRAKGTGYFFVLKSKVA------DGTPCSP-------------DSTTVC VQGQCVKAGCDRVIGSNRRFDKCGVCGGDGSTCKKVSGSLDRARPGYQD--------------------------VVTIP AGATHVDVKQRATGNGRHDNSYLAVRRQD--GTYLLNGDYKLMTMETDVALRGAL-LRYSGSSATLERIR--SFSPLPEP LTIQVLSV-----GEAPRPRVKYSYFAPRPN---NG-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------ASTSNN-GG-------------RRPSINAIREVGGAE----------- --------------WTLREWGPCSQT----CGGG-VQQREVVCLDAYGHPSRDCPE------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------ELRPLASRSCATQPCPT---WLLGDWSVCSKTCGRGFRK-----------RQLRCIGHDGR TLTNESCDPKDRPRPLLELCTQGAC------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Tetraodon_nigroviridis_ADAMTS1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MVLLRVCL-AIIATLCVGAAH---------------GAWEESVVVPVRLDPTTPTEPWRTLSVEE------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------QQKQ----AERR--------------EYRLEAFGRDLVLQLEPDQTFLAPGFVFHMVGSPDPDPTPE-PK SGT------------------------EPGCFYSGTVNGEEHSAAALNLCHG-LRG--------------GFYLQGAEYF IQPLNSSLLAG--------------------------TEENVHMIRRRSRATLAEE------------------------ ---------------GGSKCGVNEDEKRVPINLEREAG-GAVNG---------------AQT-------------VHHRT RRFVS--------------------------------------TPRYLEIM-IVADQSMAEFHG--AGLKPYLLTIMAVA SR-------------------------------LYRHAS--IHNSISLAVVKLLVVYEEE-----HGPQVSSNAAMTLRN FCQWQRQHNP-ASDRHP----------EHYDTAVLFTR-----TDLCGAHS---CDTLG-MADVGTVCDPDRSCSIIEDD GLQAAFTVAHELG-HVFNMPHDDAQMCSEVNGAHWGS---HMMASTLSNLDQQ-QPWSPCSALMVTTFLDNGHG--QCLL DKPVRPQ----ALPQ----PLPGS--VYDADHQCRLTFGED---------------SQHCSD------------------ ------------------------------------------------------------------PNTTCAALWCTVTT PNGLLVCQTKN--FPWADGTPCGHDS----SCLAGQCLTRSQAAKH-QI---PVNGGWGL------WGPWGDCSRTCGGG VQYSFRSCDNPL---------------PRNGGKYCEGKRIQYRSCNTET----CPDTN---GLTFREEQCLAHNDMSAQV SLGSGEGVEWVPKYAGISPKDRCK-----LVCRAKGTGYFFVLKSKVA------DGTPCSP-------------DSTTVC VQGQCVKAGCDRIIGSNRRFDKCGVCGGDGSTCKKVSGSLVRARPGYQD--------------------------VVTIP AGATHVDVKQRAAGNGRHDNSYLAVRRQD--GTYLLNGDYKLMTMETDIALRGAL-LRYSGSSTTLERIR--SFSPLPEP LTIQVLSV-----GEAPRPRVKYSYFAPRPN---NG-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------ASTSNN-GG-------------RRQSINAITEVGGAE----------- --------------WTL--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Gasterosteus_aculeatus_ADAMTS1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------LDVFGKELVLQLEPDQTFLAPGFVFHIVGSPDTDPTQE-PK SGA------------------------EPGCFFSGTVNGEEHSAAALNLCHG-LRG--------------GFYFQGAEYF IQPQNSINFTG--------------------------TEKDVHVIRRRDRAVLAEE------------------------ ---------------GSSKCGVNEDEEKVPKNLEKEDQHGAANA---------------DQTDYTSVTNGNRHGKEHHRT RRFVS--------------------------------------TPRYMEIM-LVADQSMAEFHG--AGLKPYLLTIMAVA SR-------------------------------LYRHPS--IHNSISLAVVKLLVVYEEE-----RGPQVSSNAAMTLRN FCQWQRQHNP-PSDRHP----------EHYDTAVLFTR-----TDLCGAHS---CDTLG-MADVGTVCDPERSCSIIEDD GLQAAFTVAHELG-HVFNMPHDDAQLCSGVNGAHWGS---HMMASTLSDLDQQ-QPWSPCSALMITTFLDNGHG--QCLL DKPVKPQ----ALPQ----PLPGT--VYDADHQCRLTFGDD---------------SQHCTD------------------ ------------------------------------------------------------------LSTVCAALWCTVTT SNNLLVCQTKN--FPWADGTTCGHDS----YCLAGHCLSKSQAAKH-QT---PVNGGWGV------WGPWGDCSRTCGGG VQYSFRSCENPL---------------PKNGGKYCEGKRIQYRSCSTDT----CPETN---GLSFREEQCLAHNDMTAQV SLGSGEGVEWVPKYAGVSPKDRCK-----LVCRAKGTGYFFVLKSKVA------DGTPCSP-------------DSTSVC VQGQCVKAGCDRVIGSSRRFDKCAVCGGDGSTCKKVSGSLERARPGYQD--------------------------VVTIP AGATHLDVKQRTPGNGRQDNSYLAVRRQD--GTYLLNGDYKLMTMETDIALRGAM-LRYSGSSATLERIR--SFAPLPEP ITIQVLSV-----GEAPRPRVKYSYFAPRPS---NA-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------ASVSNNNGG-------------RRHSINAIREVGVAE----------- --------------WTLREWGLCSQT----CGGG-TQQREVVCLDPQGRLSRDCPE------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------ELRPLASRSCATQSCPY---WLLGEWSACSKNCGRGFRK-----------RQLRCIGHDGR TLTHESCDPKDRPKPLLELCNQTAC------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Oryzias_latipes_ADAMTS1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MWLLHVS----IVALCVGAAL---------------CTWEESTVVPVRLEPDQR-EPWRTLSAEE------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------EQKV----GEMR--------------VYQLDVFGKQLILRLEPDQTFLAPGFVFHVVGSPESVPALAGSD SGS------------------------EPGCFFSGTVNGEAHSAAALNLCRG-LSG--------------GFFFEGNEYF IQPLDSSELD------------------------------QVHSIRRRSRAAHKEE------------------------ ---------------GSSKCGVNEDEERMPKNPGEEASHGAPNA---------------EQT-------------ARQRT RRFVS--------------------------------------TPRYLEIM-LVADQSMAEFHG--AGLKPYLLTIMAVA SR-------------------------------LYRHPS--IHNSISLAVVKLLVVYEEE-----KGPQVSSNAAMTLRN FCQWQRQHNP-TSDRHP----------EHYDTAVLFTR-----TDLCGAKN---CDTLG-MADVGTVCDPERSCSIIEDD GLQAAFTVAHELG-HVFNMPHDDAQLCSGVNGPHWGS---HMMASTLSNLDQQ-QPWSPCSALMITSFLDNGYG--QCLL DKPVKPQ----PLPQ----PLPGT--VYDVNHQCRLIFGDD---------------SKHCQE------------------ ------------------------------------------------------------------HSSTCAVLWCTVTL PSGLMVCQTKN--FPWADGTACGTES----YCLAGQCLTKSQAAKHQQT---PVNGGWGL------WGPWGDCSRTCGGG VQYSFRSCDNPL---------------PKNGGKFCEGKRIQYRSCNTET----CPDTN---GLSFREEQCLAHNDMSAQV SLGSGEGVEWVPKYAGVSPKDRCK-----LVCRAKGTGYFFVLKPKVA------DGTTCSP-------------DSTSVC VQGQCVKAGCDRIIGSNRRFDKCGVCGGDGSTCKKVSGSLDRARPGYQD--------------------------IITVP AGATHLDVKQRAPGNGRNDNSYLAVRRQD--GTYLLNGDYKLMTMETDIAMRGAL-LRYSGSSATLERLR--SFAPLPEP LTIQVLSV-----GEAPRPRVKYSYFAPRPN---NG-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------ASASNNNGA-------------RRQSINAIRDVGTAD----------- --------------WTLREWGMCSQT----CGGG-IQQREVVCLDPQGRPSLDCPE------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------ELRPLASRPCASQECPT---WLLGEWSGCSKTCGRGFRK-----------RQLSCIGHNGR TLTNDSCDSKNQPRPLLELCNQTAC------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Homo_sapiens_ADAMTS2 -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MDPPA GAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVR ARRAAPVRTPSF-------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------PGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQ-GEKGT------- ---------------------TRVEPLLGSCLYVGDVAGLA-EASSVALSNCDGL-------------AGLIRMEEEEFF IEPLEKGL------------------------AAQEAEQGRVHVVYRR----PPTS--PPLGGPQALD------------ --------------TGASLDSLDSLSRALGVLEEHANSS-RRRARRHAADDD---------------------------- ---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMN-- -----------------------------IVNEIYHDES--LGAHINVVLVRIILLSYGK----SMSLIEIGNPSQSLEN VCR--WAYLQQKPDTG---------HDEYHDHAIFLTRQD---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPF AHDWP-------------ALPQLPGLHYSMNEQCRFDFGLG---------------YMMCTA------------------ ----------------------------------------------------------------FRTFDPCKQLWCSHPD N--PYFCKTKK--GPPLDGTMCAPGK----HCFKGHCIWLTPDIL-------KRDGSWGAWS------PFGSCSRTCGTG VKFRTRQCDNPH---------------PANGGRTCSGLAYDFQLCSRQD----CPD----SLADFREEQCRQWDLYFEHG DAQHHWLPHEHRDA-----KERCH-----LYCESRETGEVVSMKRMVH------DGTRCSYK------------DAFSLC VRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHG------------------------YIKMFEIP AGARHLLIQEVDATSHH-----LAVKNLET-GKFILNE---ENDVDASSKTFIAMGVEWEYRD-EDGRETLQTMGPLHGT ITVLV-----IPVGD-TRVSLTYKYMIHEDSLNVDDNNVLE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------EDSVVYEWALKKWSPCSKP----CGGGSQFTKYGCRR-RLDHKMVHRGFCAA--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------LSKPKAIRRACNPQECSQPVWVTGEWEPCSQT--CGRTGMQVRSVRCIQ-PLHDNTTRSVH AKHCNDARPESRRACSRELCPGRWRAGPWS-QCSVTCGNG------------------------------TQERPVLCRT ADDSFGI------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CQEERP-ETARTCRLGPCPRNISDPSKKS---------YVVQWLSRPDPDSPIRKISS------------ -----------------------------KGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNNLTNVEGR----- --IEPPP------------------GKHNDID------------------------------------------------ ------------VFMPTLPVPTVAMEVRPSPST--PLEVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPN----- ---------------------------------LIP--RRPSPYEKTRNQRIQELIDEMRKKEMLGKF------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Mus_musculus_ADAMTS2 -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MDPPA GAARRLLCPALLLLLLPPPP-LLLLPPPPASVRLVAATEPPGGPPGQGAERILAVPVRTDAQGRLVSHVVSLETAGAGVR ARRAALDQTSGL-------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------PGGAAQDPGGRLFYNLTVFGRDLHLRLRPNARLVAPGATVEWQ-GETGD------- ---------------------TRVEPLLGSCLYVGDVADLP-KASSVALSNCDGL-------------AGLIRMEEEEFF IEPLEKGQ------------------------TDQEAEQGRVHVVYRR----PPTPKPPPVSEPQALD------------ --------------TGVSQGNLDSLSRALGVLEERINSS-RRRVRRHATDDD---------------------------- ---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMN-- -----------------------------IVNEIYHDES--LGAHINVVLVRIILLSHAK----SMSLIEIGNPSQSLEN VCR--WAYLQQKPDTD---------HDEYHDHAIFLTRQD---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLRDDPF AHDWP-------------ALPQLPGLHYSMNEQCRFDFGLG---------------YMMCTA------------------ ----------------------------------------------------------------FRTFDPCKQLWCSHPD N--PYFCKTKK--GPPLDGTMCAPGK----HCFKGHCIWLTPDIL-------KRDGNWGAWT------PFGSCSRTCGTG VKFRTRQCDNPH---------------PANGGRTCSGLAYDFQLCNPQD----CPN----SLADFREEQCQQWDLYFEHG DVQHHWLPHEHRDA-----KERCH-----LYCESKETGEVVSMKRMVH------DGTRCSYK------------DAFSLC VRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQD------------------------YIKMFEIP AGARHLLIQEADTTSHH-----LSVKNLET-GKFILNE---ENHLDPNSRSFIAMGVEWEYRN-EDERETLQTIGPLHGT ITVLV-----IPEGD-TRISLTYKYMIHEDSLNVDDNNVLE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------DDAVRHEWALKKWSPCSKP----CGGGSQFTKYGCRR-RLDSKMVHRAFCSA--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------LAKPKAIRRACNPQECSQPVWVTGEWEPCTQS--CGRTGMQVRSVRCIQ-PLHNNTTRSVH TKHCNDHRPESRRACNRELCPGRWRAGSWS-QCSVTCGNG------------------------------TQERPVLCRT ADDNFGV------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CREERP-ETARICRLAPCPRNGSDPSKKS---------YVVQWLSRPDPDSPIQKISS------------ -----------------------------KDQCQGDKSMFCRMEVLSRYCSIPSYNKLCCKSCNPPRNLSNTEDGG---- --VEPPP------------------GKHNDID------------------------------------------------ ------------VFMPTLPGPTVATQVQPSPGP--PLEAPLNVSSTNATEDHPETNAVDVPYKIHGVDEEVPSPN----- ---------------------------------LIP--RRPSLYVKTRNQRIQELINAVQRKEKPGKF------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Dasypus_novemcinctus_ADAMTS2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------VPPASLDTLSRALGVLEERVNSS-RRRVRRHTADDD---------------------------- ---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMN-- -----------------------------IVNEIYHDES--LGAHINVVLVRIILLSYGK----SMSLIEIGNPSQSLEN VCR--WAYLQQKPDTD---------HDEYHDHAIFLTRQD---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELGRYLHSYDCLRDDPF AHDWP-------------ALPQLPGLHYSMNEQCRFDFGLG---------------YMMCTA------------------ ----------------------------------------------------------------FRTFDPCKQLWCSHPD N--PYFCKTKK--GPPLDGTMCAPGK----HCFKGHCIWLTPDIL-------KRDGNWGAWT------PFGSCSRTCGTG VKFRTRQCDNPH---------------PANGGRTCSGLAYDFQLCNPQD----CPD----ALVDFREEQCRQWDLYFEHG NGQHHWLPHEHRDA-----KERCH-----LYCESQETGEVVSMKRMVH------DGTRCSYK------------DAFSLC VRGDCKKVGCDGVVGSSKQEDKCGVCGGDNSHCKVVKGMFTRSPKKQG------------------------YIKMFEIP AGARHLLIQEADSTRHY-----LAVKNLET-GKFILNE---ENDVDPNSKSFIAMGVEWEYRE-DDERETLQTIGPLRGA IAVLV-----IPEGD-ARISLTYKYMIHEDSLHVDDNNVLE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------EYSLGYEWALKKWSPCSKP----CGGGSQFTKYGCRR-KLDHKLVHRGFCKA--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------LAKPKAIRRVCNPQECSQPVWVTGEWEPCSQS--CGRSGMQARSVRCIQ-PLHDNTNRSVH TKYCNNARPEGRRACNRELCPGRWRAGPWS-QTTLACAKGG-----------------------------VSKREVTCKT MSRRFGM------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------RRKQVS-QKGREAVIGPTHREADHLKKKG---------YVRRWSSHPDHSYLSHFSFS------------ -----------------------------EGHCQGDKSMFCRMEVLSRYCSIPGYNKLCCKSCNLHN-STSVDDR----- --TEPPP------------------GKQNDIE------------------------------------------------ ------------ELMPTLPVPTLVMEVHPPPAV--PLEVPLNASSTNATQDHPETNAVDVPYKIDGLDNEVQPPN----- ---------------------------------LIP--RRPSLFEKTRNQRIQQLIDEMRKKRCSESS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Gallus_gallus_ADAMTS2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MEPPAGFACVLLCCALCLPAAAPRRPGHRDPILRNIEEYSLVIPTSTDSEGRFLSHLVSGPPKARFRR AADDLQHKAA---------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------NEQIFYNVTVFGREFHFRLRPNSRLVAPGATVEWQ-EDSDE------- ---------------------THIEPLYGNCLYVGDITDLP-NAS-VAISNCDGL-------------AGMIRTDKDEFF IEPLEKGT------------------------REEEEEGGRTHVVYRR----AAAKKQLPIEDADTLY------------ --------------KAPNLTNLDGLDSALSLIEDGVRRS-RQRHRRHATDDD---------------------------- ---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMNI- ------------------------------VNEIYHDES--LGAHINVVLVRIILLSYGK----SMSLIEIGNPSQSLEN VCR--WAYLQQKPDTG---------HAEYHDHAIFLTRQD---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELNRYLHSYDCLRDDPF EHDWP-------------SLPQLPGIHYSMNEQCRFDFGLG---------------YMMCTA------------------ ----------------------------------------------------------------FRTFDPCKQLWCSHPE N--PYFCKTKK--GPPLDGTMCAPGK----HCFKGHCIWLTPDIL-------KQDGHWGAWS------KFGSCSRTCGTG VKYRTRQCDNPH---------------PANGGRTCVGPSYEFQLCNTQD----CPK----DFEDFREEQCRQWDPYFEYQ NTKHHWLPYEHVDA-----KERCH-----LYCESKETGDVVYMKRMVH------DGTRCSYK------------DAYSIC VRGECLKVGCDRVIGSTKQEDKCGVCGGDNSHCKVVKGTFSRVPKKQG------------------------HIKMFEIP VGARHLLIQESDATSHH-----LAIKNRET-GRFILSE---DNYVP-DSKVFIDMGVEWEYRN-DDNRETVQTMGPLRNG IVILV-----IPHGG-AKISLTYKYMIHEDSLNVDNNNVLE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------EDSVSYEWALKKWSQCSRP----CGGGFQFTKYGCRR-KTDHKMVHRSYCEL--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------IQKPKPIRRVCNLQECSQPIWVTGEWEPCSKS--CGKTGYQVRSVRCIQ-PLHDNTNRSVH TKYCNNDRPEGRRPCNRELCPAQWRIGPWS-QCSVSCGNG------------------------------TQDRPVLCRT SDNAIGL------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CKEAKP-ENVKICRLPPCPRNISDPSKKT---------YMIQWLSRPDPDYPIQKISS------------ -----------------------------KDHCQGDKSMFCRMEVLSRYCSIPGYNKLCCKSCNMYNNVTEEGNA----- --TDSNA------------------NKNNVIE------------------------------------------------ ------------EELLTTPSPLTGVPTTQPATTSPPPVSKPPMPPSNATDEHPEINAVDVPYKIDGLDNEVSQHN----- ---------------------------------IIT--QRRIPYERTRNQRIQELIAEKRKKETLRRIN----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Xenopus_tropicalis_ADAMTS2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------EYSLVTPVSTDSKGKYVSHSVTKRETHRYRR DASN---------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEKTSAERIYYNVTVFGREFHLKLRVNSKLVAPGATIEWE-EDANV------- ---------------------TVIEPLNTNCLYVGDITDLP-NAS-VAISNCDGL-------------AGIIRTEEEEFF IEPLEKD--------------------------KEGEDEGRVHIVYRRNHTPPTLGPPKILAQIHRAD------------ --------------TKTTQHSPNLLENIIDNVQEQVNST-RKRTRRHASDDD---------------------------- ---------------------------------------------FNIEILLGVDDSVVQFHGKEY--VQKYLLTLLN-- -----------------------------IVNEIYHDES--LGAHINVVLVRIIMLSHSK----SSSLIEVGNPSQSLEN VCR--WAYLQQKPETG---------HAEYHDHAIFLTRQE---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRMGSIMAPLVQAAFHRFHWSRCSQQELSRYLNSYDCLRDDPF EHNWP-------------SLPQLPGIHYSMNEQCRFDFGLG---------------YMMCTA------------------ ----------------------------------------------------------------FRTFDPCKQLWCSHTD N--PYFCKTKK--GPPLDGTMCSYGK----HCFKGHCIWLTPDIL-------RQDGNWGQWS------KFGSCSRSCGTG VRYRTRSCDNPH---------------PANGGRSCSGPSYELQLCNTED----CKT----DFDDFREEQCKQWDPYFEYQ DSKHNWLPYDHPDE-----KERCH-----LYCQSKETGDVVYMKRLTH------DGTRCSYK------------DSYNIC VRGECLKVGCDKVIGSKKKEDKCGVCGGDNSHCKVVKGTFTRTPRKQG------------------------NVRIFEIP VGARHLLIQETGASIHN-----LAIKNQAS-GKFILND---ENVTLPDSKIFVNMGIEWEYQN-DDNRETVQTMGPLHNP ITILV-----IPRGH-SKISLSYKYMIHEDSFNVDNNNVVE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------DVVVTYEWTLKKWSHCSKP----CGGGHQFTKYGCRR-KSDHKMVHKNFCDS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------IQKLKPIRRVCNLQECSQPLWISGEWEPCTVT--CGKSGYQFRTVKCIQ-PLNDNKNRSVH NKYCSDDRPEAKRPCNRQPCPAQWRIGPWS-QCSVTCGNG------------------------------TEERQVHCGS DINKSAN------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CSEEKP-ETIRICRLSPCSGNASDPYKKN---------YIVQWLSKLDPDYPLHKISS------------ -----------------------------KESCLEDKSMVCRLGILQRYCSVPGYSRMCCKACN----ASQLYND----- -------------------------SKMNSSS------------------------------------------------ ------------DPALPIPSPPTLYNTTVTFTP----DYKQNVSNPNITDQLN--NRVDVPYKIQELQNEVPQLN----- ---------------------------------AIP--RRRSTFGRTKNQRIQQLIAEKVKQESKSKF------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Danio_rerio_ADAMTS2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MDVTPGCAFFIFFLHFQRADTLYIANSIDSLQHVLREYGLVRPVSVDADGHFLTHAVSASRLSGQGS HRRRRRQANQ---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------QGETDHLRETLFYNVTVYGQEFHLRLRLNSRLVAPGAKVEWLEDDNQT------- ---------------------HSEPLLPSDCLYVGYVTNVQ-DTS-VAISNCDGL-------------AGMIRAGQEEFF IEPLERGGDMTGE---------------------EEGGPGRHHIVYRS----SDIKKPAVNQPADFHP------------ --------------RGSPLGGLAALELLPQHVKKKIN----SRARRETYEDEI--------------------------- ---------------------------------------------FNIEVLLGVDCSVVMFHGREH--IQKYLLTLMN-- -----------------------------IVNEIYQDST--LGAHINVVLVRIMMLCSSK----SMGLIELGNASQSLEN VCR--WAFLQQKEDKN---------DAEYHDHAIFLTRQE---FGPTGMQ---------GYAPVTGMCHPVRSCTLNHED GFSSAFVVAHETG-------HVLGMEHDGQANECGDEVPMGSIMAPLVQAAFHRFHWSRCSQQELRRYLNTYDCLRDDPF DHEWP-------------TLPQLPGLQYSMDEQCRFDFGMG---------------YMMCTA------------------ ----------------------------------------------------------------YSTYDPCKQLWCSHPE N--PFFCKTKK--GPPIDGTKCASGK----NCFKGHCIKLTPDIL-------RLDGHWGQWT------KFGSCSRTCGGG VRFRTRECNNPV---------------PANGGRTCYGNNYEFQLCNTEE----CAE----ALVDFREEQCKMWDPHFEHE GNKHHWLPYEHSEP-----DERCQ-----LYCQSKETGDVVSMKRMVH------DGTRCSYK------------DPYSVC VRGECEKVGCDNVIASELEDDKCGVCGGDNSTCKIVKGNFTRSTRKPG------------------------FLKILEIP RGARHIQIHEFKGTPHI-----LAVKNQAT-DHLFLND---EGDFP-ESRTVIEKGVAWEYTN-NDDMETVQTTGPLRYG VLIMV-----QSHSI-SKVTISYKYILPEDPLSSMENTLPQ--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------DDTIYFEWALRKWSHCSKP----CGGGKQYTRFGCRR-KSDGKMVHRTLCAN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------IPKPRAISRACNQKECSEPIWVTGEWEECSKS--CGKTGSQTRPVRCVR-PELDGSYKAIN AKYCNDDRPEGRRPCNRQLCPAHWRTGPWS-QCSVSCGNG------------------------------TQERQVMCST PDNAIGI------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CMDTKP-QSVRSCLPAPCP------NDRGN--------FLIQWLSRADPEFPAPKISS------------ -----------------------------RSRCKGDKSVFCRMEVLSMYCSNPGYRQMCCKSCS-ETNYTSQFNLTRPWT YTTATPPKTPIRTTLLFRTSQKPSTTTTPSISRWTDISPTSATTKTLKQTTTITFTTGAFTKHPDSFDYEEESSGSFYED ETWSSVSESESSEFISSSSKPWSTTPQYTTTPE----NENIEMTLLTTPQPNVTATTSPPAIVSLHLSEDKKENNS---- ----------------IDVSYRIVSPNEVALNHFVPR-KRVSFREKTQNKRIQELLAEKRRQDFLLQRLKRKPGD----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Tetraodon_nigroviridis_ADAMTS2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------LVRPISVDAEGRFLSHAVSAGRVVGGQP RRRRRRDVGIGPDEWE---------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------EPKAEHVADREKLYYNVTIFGREFHLRLRHNTRLVAPGAKMEWHDDSDST------- ---------------------RRTEPLHDACLYVGDITDTP-GAT-VAISNCDGL-------------AGMIRMEQEEFF IEPVERGAGVIEE-------------------KEQEGGGGRTHIVYRS----SAVKKNSPVHSPHALC------------ --------------AGADLGAMMDLESLHRGVEQSINHTRAGRMRRQSLERS---------------------------- ---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMN-- -----------------------------IVNEIYHDQS--LGAKINVVLVRIIMLGYGK----SMSLIELGNPSQSLEN VCR--WAFLQQKQDTG---------DAEYHDHAIFLTRQE---FGPTGMQ---------GYAPVTGMCHPVRSCTLNHED GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVHMGSIMAPLVQAAFHRFHWSRCSMQELGRYLHSYDCLRDDPF DHNWP-------------SLPQLPGLHYSMNEQCRFDFGVG---------------YTMCTA------------------ ----------------------------------------------------------------YRTFDPCKQLWCSHPD N--PFFCKTKK--GPPIDGTMCGNGK----HCFKGHCIWLTPDII-------KQDGNWGAWS------EFGQCSRTCGGG VKFRTRNCDNPR---------------PANGGRTCVGATYQFQMCNTNE----CED----IYNDPREEQCRTWEPDFELH SNKHHWLPYEHPDP-----NKRCN-----LHCQSKETRAVALTDRVVL------DGTRCSYK------------DPHSVC VRGECEKVGCDGVFGSSKQEDKCGVCGGDNSSCKTFKDTITRTSKKQG------------------------CLKVIEIP RGARHLLIQELKATSHT-----LAVKNVAS-GLFFVNG---ENEYP-ESHSVIEKGVEWEYEY-DNGKETLQTSGPLRHG ILIMM-----KLHGD-EDVNLSYKYMMNMDSDTAIQNNMLV--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------EDSS-YEWAPKKWSYCSRP----CSGGKQYLRYGCRR-KVDSKMVHKSFCNKS-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------NMKPRGDVRDCNQKPCPPPVWVTGEWQNCSKT--CGKTGTQIRTVSCMQ-PSEDNTTRSIH NKHCNDHRPESRRACNRHPCPTQWRVGPWT-QCSVTCGNG------------------------------TQQRKALCHT RDNTIGL------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CLDSKP-DTIRVCRLDPCPKGSSDLNKNGN--------ILIQWLSRPN---PYPKISS------------ -----------------------------RQRCTGDRSSFCRIEALKRHCSLPDFRRMCCQSCGGVTNSSGGFVPIRPR- --VTSPP------------------TSTSSIN------------------------------------------------ ------------YFLPSSFKPEVTTELFPSTIP----STGVPLTTVTTGSTKDPTTRARTPLWNTGVDGDVPQNN----- ---------------------------------QIPK-RRVNFRERTKNKRIQELLEEKR--NFLLRKKRGHA------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Homo_sapiens_ADAMTS3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSAR DVSS---------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------NPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPI NNHQPGS---------ATYRIRRTEPLQTNCAYVGDIVDIP-GTS-VAISNCDGL-------------AGMIKSDNEEYF IEPLERG-------------------------KQMEEEKGRIHVVYKR----SAVEQAPIDMSKDFHY--RE-------- ----------------SDLEGLDDLGTVYGNIHQQLNET-MR-RRRHAGEND---------------------------- ---------------------------------------------YNIEVLLGVDDSVVRFHGKEH--VQNYLLTLMN-- -----------------------------IVNEIYHDES--LGVHINVVLVRMIMLGYAK----SISLIERGNPSRSLEN VCR--WASQQQRSDLN---------HSEHHDHAIFLTRQD---FGPAGMQ---------GYAPVTGMCHPVRSCTLNHED GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPF DHDWP-------------KLPELPGINYSMDEQCRFDFGVG---------------YKMCTA------------------ ----------------------------------------------------------------FRTFDPCKQLWCSHPD N--PYFCKTKK--GPPLDGTECAAGK----WCYKGHCMWKNANQQ-------KQDGNWGSWT------KFGSCSRTCGTG VRFRTRQCNNPM---------------PINGGQDCPGVNFEYQLCNTEE----CQK----HFEDFRAQQCQQRNSHFEYQ NTKHHWLPYEHPDP-----KKRCH-----LYCQSKETGDVAYMKQLVH------DGTHCSYK------------DPYSIC VRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLG------------------------YLKMFDIP PGARHVLIQEDEASPHI-----LAIKNQAT-GHYILN----GKGEEAKSRTFIDLGVEWDYNI-EDDIESLHTDGPLHDP VIVL-I----IPQENDTRSSLTYKYIIHEDSVPTINSNNVIQ-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------EELDTFEWALKSWSQCSKP----CGGGFQYTKYGCRR-KSDNKMVHRSFCEA--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------NKKPKPIRRMCNIQECTHPLWVAEEWEHCTK--TCGSSGYQLRTVRCLQ-PLLDGTNRSVH SKYCMGDRPESRRPCNRVPCPAQWKTGPWS-ECSVTCGEG------------------------------TEVRQVLCRA GDH----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------