>Homo_sapiens_ADAM7 --------------------------------------------------------------------------MLPGCI FLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDT---------GHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRS REFLGSNYSETFYSMKGEAFTRHPQ-----IMDH-CFYQGSIVHEYDSAASISTCNGLR---GFFRINDQRYLIEPVK-- YSD-------------EGEHLVFKYNLRVPYGANYSCTELNFT---------------------------------RKTV PG-DNESE--EDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNR------IWGMVNFVNMIYKTLNIHVTLVGIEI WTHEDKIELY--SNIETTLLRFSFWQEKILKTRKD-FDHVVLLSGKWLYS------HVQGISYPGGMCLPYYSTSIIKDL LP-DTNIIANRMAHQLGHNLGMQHD--EFPCTCPSGKCVMDSDGSIP-------------ALKFSK-CSQNQYHQYLK-- DYKPTCMLNIPFPYN-FHDFQ-FCG--NKKLDEGE--ECDCG-PAQ---ECTNPCCDAHTCVLKPGFTCA-EGECCESCQ -----IKKAGSICR-PAKDECDFPEMCTGHSPACPKDQFRVNGFPCKN-----SEGYCFMGKCPTREDQCSELFDD---- -EAIESHDICYKMNTKGNKFGYCKN-KENRFLPCEEK--DVRCGKIYCTGGELSSLLG-----EDKTYHLKDPQKN---A T-----VKCKTIFLYH---------DS--TDIGLVASGTKCGEGMVCNNGECLNMEK-----------------VYI--S TNCPSQCNEN--------------------------------PVDGHGLQCHCE-EGQAP-VACEETLH---VTNIT--- ----------------------ILVVVLVLVIVGIGVL---------------ILLVRYRKCIKLKQ------------- -------------------------------------------------------------------------------- ---------------------------VQSPPTETL-GVENKGYFG-D-------------------------------- ----------------EQQIRTEPILPEIHFLNQR-----------------------------TPESLESLPTSFSSPH YITLKPASKDSRGIADPNQSAK---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Pan_troglodytes_ADAM7 --------------------------------------------------------------------------MLPGCI FLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDT---------GHTHDDDIPKTYEEELLYEIKLNRKTLVLHLLRS REFLGSNYSETFYSMKGEAFTRHPQ-----IVDH-CFYQGSIVHEYDSAASISTCNGLR---GFFRINDQRYLIEPVK-- YSD-------------EGEHLVFKYNLRMPYVANYSCTELNFT---------------------------------RKTV PG-DNESE--EDSKIKGIHDEKYVELFIVADDTVYRRNSHPHNKLRNR------IWGMVNFVNMIYKTLNIHVTLVGIEI WTHEDKIELY--SNIETTLLHFSFWQEKMLKTRKD-FDHVVLLSGKWLYS------HVQGISYPGGMCLPYYSTSIIKDL LP-DTNIIANRMAHQLGHNLGMQHD--EFPCTCPSGKCVMDSDGSIP-------------ALKFSK-CSQNQYHQYLK-- DYKPTCMLNIPFPYN-FHDFQ-FCG--NKKLDEGE--ECDCG-PAQ---ECTNPCCDAHTCVLKPGFTCA-EGECCESCQ -----IKKAGSICR-PAKDECDFPEMCTGHSPACPKDQFRVNGFPCKN-----SEGYCFMGKCPTREDQCSELFDD---- -EAIESHDICYKMNTKGNKFGYCKN-KENRFLPCEEK--DVRCGKIYCTGGELSSLLG-----EDKTYHLKDPQQN---A T-----VKCKTIFLYH---------DS--TDIGLVASGTKCGEGMVCNNGECLNMEK-----------------VYI--S TNCPSQCREN--------------------------------PVDGHGLQCHCE-EGQEP-VACEETLN---VTNIT--- ----------------------VLVVVLVLVIVGIGVL---------------ILLVRYRKCIKLKQ------------- -------------------------------------------------------------------------------- ---------------------------VQSPPTETL-GVENKGYFG-D-------------------------------- ----------------EQQIRTEPILPEIHFRNQR-----------------------------TPESLESLATSFSSPH YITLKPASKDSRGIADPNQSAK---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Mus_musculus_ADAM7 --------------------------------------------------------------------------MLTTGI FWMTVLISHIQERGIVGVEGQELVHPKKLPLLHKRDL---------ERIHDSDIPEEYEEELLYEIKLGKKTLILHLLKA REFLSSNYSETYYNVKREVFTKHPQ-----ILDH-CFYQGSIIHEFDSAASISTCNGLR---GFFRVNDQRYLIEPVK-- YSD-------------DGEHLVYKYNVKAPYATNHSCVGLNFT---------------------------------KKSA LI-DVENI--EEHNAEDHHKEKFIELFVVADEYVYRRNNKPQNKLRKR------IWGMVNFVNMIYKTLNIHVTLAGFEI WSAGDKIEIV--SNLESTLLHFSTWQETVLKKRKD-FDHVILLSGKWLYT------SMQGIAYPGGICQILRSCSVVKDL LP-DVNIIGNRMAHQLGHSLGMQHD--GFPCTCPLGKCVMG-DGSIP-------------AIKFSK-CSQTQYQQFLQ-- DQKPACILNNPFPEE-FNDYP-FCG--NKKVDEGE--ECDCG-PVQ---ECTNPCCDAHKCVLKPGFTCV-EGECCESCQ -----MKKEGAVCR-LAKNECDISEVCTGYSPECPKDEFQANGFPCRN-----GEGYCFMGLCPTRNEQCSELFIG---- -GAEESHSLCYRMNKKGNRFGYCKN-KGNTFVPCEEK--DLKCGKIYCSGGRPSSRLG-----EDKAYNLKNVKQN---V T-----IKCRTMFLHH---------NS--RDMGLVNSGTKCGDGMVCSNGECIEMEK-----------------AYN--S TICSSPCDEN--------------------------------DVDDNEPECQCE-EGSII-TEWGEALN---LTSVS--- ----------------------IMVIVLVMVIIGVGLV---------------ILLIRYQKCIKMKQ------------- -------------------------------------------------------------------------------- ---------------------------VQSSPREIR-GVENKGYFP-E-------------------------------- ----------------EHQTRSEPILTDIHPLHT------------------------------TAESLERVPSSFSSPH YITLKSVSKDSRGIADPKQTDN---------------------------------------------------------- ------------VNLNLDTQSGCERLG----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Rattus_norvegicus_ADAM7 --------------------------------------------------------------------------MFPTGI FLMSVLISQMQGRGIVGVEGQELVHPKKLSLLQKRDL---------ERIHDSDTPEEYEEELLYEIKLGRKTLTLHLLKA REFLALNYSETYYNIKREMVTRHPQ-----ILDH-CFYQGSIIHEFDSAASISTCNGLR---GFFRVNDQRYLIEPVK-- YSD-------------EGDHLVFKYNVKAPYATNYSCEGLNFT---------------------------------KKST LI-DAKNI--EEHKVEDYHKEKFIELFVVADEFVYRRNSKPQNKLRKR------IWGMVNFVNMIYKALNIRVTLTGMEI WSAGDEIEIV--SNLESTLLHFSTWQETVLKKRKD-FDHVILLSGKWLYT------SMQGIAYPGGICQTLRSCSVVKDL LP-DVNIIGNRMAHQLGHSLGMRHD--DFPCTCPLGKCVMG-AGSIP-------------AIKFSK-CSQTQYQQFLK-- NQKPACILNNPLPEE-FNDYP-FCG--NKKVDEGE--ECDCG-PVQ---ECTNPCCDAHKCVLKPGFTCV-EGECCESCQ -----MKKEGVICR-PAKNECDISEVCTGYSPECPKDESQANGFPCKN-----GEGYCFMGLCPTRDDQCAELFSG---- -GAEESHSLCYRMNQKGNRFGYCKN-KDNTFVPCEEK--DLKCGKIYCTGGRRSAHLG-----EDKTYNLKNVKQN---I S-----IKCKTMFLYH---------NS--RDMGLVNSGTKCGEGMVCSNGECIEMEK-----------------AYN--S TICSSLCDEN--------------------------------DVDDNEPDCQCE-EGPII-TEWGEALN---LTSVS--- ----------------------IMVVVLVMVIIGVGLV---------------ILLIRYQKCIKMKQ------------- -------------------------------------------------------------------------------- ---------------------------VQSSSREIR-GIENKVYFP-D-------------------------------- ----------------EHQTRSEPIFTDIYPLHN------------------------------TAESLERVPSTFSSPH YITLKSVSKDPRGIADPKQNDN---------------------------------------------------------- ------------MNLNLDSQSDCTRLG----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Canis_familiaris_ADAM7 --------------------------------------------------------------------------MFLRSL LFMIILISQIKEKVIIGVEGQEVVYPKKLPLMQKREV---------WHIHDYDIQETYEEELLYELRLTRKTLILHLLRS REFLGLNYSETYYSTKGEMITSYPS-----TTDH-CFYQGSIIHEFDSAASISTCNGLR---GFFRVYDQRYLIEPVK-- YSD-------------EGQHLVFRYNPKMQYAANYSCTELNFT---------------------------------RKND PKDDIKIM--EDLKIERIHKEKYVELFIVADNNVYRRNSSPLSNLRNR------IWGMVNFVNMIYKILDIHVTLVGLEI WTNEDKVHID--SNIENTLLRFSTWQEIILKKRNN-FDHVLLLSGKWLYT------HAQGTSFSEGICLPYYSSSVVKDL LP-DLNVVASRIAHQLGHNFGMKHD--DYPCTCNFERCVMDRGGSIP-------------AIKFSK-CNRIQYLQHLK-- NYNPTCMFNIPFSDK-LSDYP-YCG--NKKLDEGE--ECDCG-SIQ---ECTNPCCDANKCVLKPGFTCA-EGECCESCQ Q----MKKSGSICR-PAKDECDFPEVCTGHSTACPQDKFQVNGFPCKN-----AKGYCFMGKCPTRDDQCSEFFDN---- -EVKDSSDLCYEMNKKGNRFGYCKN-KENSLIPCEEK--DVKCGKIHCSRGQHSSLLG-----KEKINHLKKISKQ--NV T-----AECKTFILYH---------NS--KDLGLVAPGTKCGDGMVCSNGECMKLEK-----------------VYN--S TNCSSQCNEN--------------------------------AVDGHDLQCQCK-EEQEH-VDWEENLN---VTNIS--- ----------------------ILAVMLVLVIFGVGVV---------------ILLIHYQKCIKLKQ------------- -------------------------------------------------------------------------------- ---------------------------IQSPPTDSL-GVENKGYFG-D-------------------------------- ----------------DQQTRTEPILPNIHPLHQR-----------------------------TAESLERLPTSFSSPH YITLKPANKDPRGIADPNQSSK---------------------------------------------------------- ------------MNLKLDIQNGCARLG----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Monodelphis_domestica_ADAM7 -------------------------------------------------------------------------------- -----------------------------------------------------FQEKYDVEVLYEMILHGKQMVLHLRKT EDLVSPNYSETHYSQGGEEITTNPK-----LMDH-CYYQGHILHEKDSAASISTCDGLR---GYFRQHDQRYLIEPLE-- HTD-------------QGEHAIFKYDHKAQDRTNGSCVVYNFS---------------------------------KTEA IT-QASRS--TLKMQIYLKEKKYIELFIVADHALYRRHNHLQKWLRTR------IFGMVNFVNMLYKTLNIQVILVGLEM WTNGDKIEVN--SNLGTTLLSFGGWQETTLKKRKN-YDHAQLLSGNWLSQ------TAQGTAYPWGMCVPFHSSSIVKDH LH-DTNMVADKMAHELAHNLGMQHD--SYPCTCTYGRCVMDGGGSIP-------------SQGFSK-CNRNQYRQYLL-- DYKPMCILNVPLSKD-IITFP-KCG--NQILEVGE--ECDCG-SLE---DCTNICCEAKKCTLKPGSTCG-GGKCCESCQ Q----IKKAGTLCR-RAKDECDLPEVCDGFSPKCPVDRFQLNGFPCQN-----SEGYCFMGKCPTRDSQCSEMFKD---- -EAKGSHDICYERNKGGHKFGYCKR-VDNKFIPCDEK--DLKCGKIYCTGGQYFPTYG-----EDKNYHLKVPDEN---I T-----VECKAFFPFQ---------YT--EDIGLVALGTKCGDGKVCKNGECVNIET-----------------VYD--S TNCSSQCPGQ--------------------------------SVCDHELQCQCE-EGLTH-PKCEDNTL---ITNVS--- ----------------------IVAGVLTVVLATIVIA---------------VLFVRRKKASKQKQ------------- -------------------------------------------------------------------------------- ---------------------------VNSSPPPTTPGADNQGHSSEG-------------------------------- ----------------QRQTRTAPLVCTQDVLNQN-----------------------------ATDTFEDIPPGYSSPQ YITMKSANKETRRIPAYNQNVR---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_ADAM7_b -------------------------------------------------------------------------------- -----------------VDGYEVVRPHRLVG---------------RPRRTPGGHQIYPDTIRYKLPIEGRNLTIHLEKN RGLLGMGYTETHYAEDGRRVTSLP------EEEH-CYYHGYVEGMEDSSVSVGLCSGI--S-GFLRTQQQVYVIEPLRRS DQ---------------GEHAVFRREQLKVSGTPGCGLTLG--TAYD------AE-------------------RGPKP- --ANLKSR--SWFSLVPPESERFVELFVVADNTEYKRHG---SETRAR------IFTAVNHINKLYWALNIRVVLVGLEI WTYKDHFDVD--GKSETTLDRFLLWRQRDLLQRVK-HDNAQFVTGKHFDG------DTVGLANKFAMCTENS-GGVNKDH HD-NPIGLASTIAHEMGHNFGLSHDA--PGCTCGPPPGSSNCVMADKLSTG-----NLAFPEFFSD-CSLEQLADFMA-- RAQPSCLSKPPSSVKTEAVAP-LCG--NRLLDAGE--ECDCG-TVE---ECDNPCCNPLTCYLTQGSQCS-DGPCCENCQ -----LKQAGSVCR-VSAGECDLADYCTGASAECPEDGFEMNGKPCYNQ----VEGYCHDGRCPTHQHHCWRLFGPG--- -AVVGLDLCFNLNKQGISDS----------YDLFSDR--NLKCGSIFCRGGGES-IT-------------GKRTEYTVSG ---------RECKQAVD-------DDK-TRNLNMVPNGARCGPNKVCLDARCVDVS------------------VYG-VR EDCAKKCNNN--------------------------------GVCNHKKECHCN-PGWAP-PYC---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Homo_sapiens_ADAM8 ------------------------------------------------------------------------MRGLGLWL LGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPR-------------VRRALPSHLGLHPERVSYVLGATGHNFTLHLRKN RDLLGSGYTETYTAANGSEVTEQPR-----GQDH-CFYQGHVEGYPDSAASLSTCAGL--R-GFFQVGSDLHLIEPLDEG GE--------------GGRHAVYQAEHLLQTA--GTCGVSDDSLGSL------LG-------------------PRTAAV FR-----P--RPGDSLPSRETRYVELYVVVDNAEFQMLGS-EAAVRHR------VLEVVNHVDKLYQKLNFRVVLVGLEI WNSQDRFHVS--PDPSVTLENLLTWQARQRTRRHL-HDNVQLITGVDFTG------TTVGFARVSAMCSHSS-GAVNQDH SK-NPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSI--------GSSFPRMFSD-CSQAYLESFLE-- RPQSVCLANAPDLSH-LVGGP-VCG--NLFVERGE--QCDCG-PPE---DCRNRCCNSTTCQLAEGAQCA-HGTCCQECK -----VKPAGELCR-PKKDMCDLEEFCDGRHPECPEDAFQENGTPCSG-----G--YCYNGACPTLAQQCQAFWGPG--- -GQAAEESCFSYDILPGCKA-------------SRYR--ADMCGVLQCKG-GQQPL--------------GRAICIVD-- -------VCHALTTEDG-------T-----AYEPVPEGTRCGPEKVCWKGRCQDLH------------------VYR--S SNCSAQCHNH--------------------------------GVCNHKQECHCH-AGWAP-PHCAKLLTEVHAAS----- -----------------------GSLPVFVVVVLVLLA---------------VVLVTLAG----IIVYR---------- -------------------------------------------------------------------------------- --------------------------KARSRILSRNVAPKTTMGRSNP-------------------------------- ----------------LFHQAA-SRVPAKGGAPAPSRGPQELVPTTHPGQP----ARHPASSVALKRPPPAPPVTVS--- -SPPFPVPVYTRQAP----------------------------------------------------------------- ------------------------KQVIKPTFAPPVPPVKP-------GAGA---------------------------- -----------------------------------------------------ANPG-PAEGAVGPKVALKPPIQRKQGA GAPTAP-------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Mus_musculus_ADAM8 --------------------------------------------------------------------------MLGLWL LSVLWTPAVAPGPPLPHVKQYEVVWPRRLAASR-------------SRRALPSHWGQYPESLSYALGTSGHVFTLHLRKN RDLLGSSYTETYSAANGSEVTEQLQ-----EQDH-CLYQGHVEGYEGSAASISTCAGL--R-GFFRVGSTVHLIEPLDA- DE--------------EGQHAMYQAKHLQQKA--GTCGVKDTNLN-D------LG-------------------PRALEI YR-----A--QPRNWLIPRETRYVELYVVADSQEFQKLGS-REAVRQR------VLEVVNHVDKLYQELSFRVVLVGLEI WNK-DKFYIS--RYANVTLENFLSWREQNLQGQHP-HDNVQLITGVDFIG------STVGLAKVSALCSRHS-GAVNQDH SK-NSIGVASTMAHELGHNLGMSHDEDIPGCYCPEPREGGGCIMTESI--------GSKFPRIFSR-CSKIDLESFVT-- KPQTGCLTNVPDVNR-FVGGP-VCG--NLFVEHGE--QCDCG-TPQ---DCQNPCCNATTCQLVKGAECA-SGTCCHECK -----VKPAGEVCR-LSKDKCDLEEFCDGRKPTCPEDAFQQNGTPCPG-----G--YCFDGSCPTLAQQCRDLWGPG--- -ARVAADSCYTFSIPPGCNG-----------RMYSGR--INRCGALYCEG-GQKPL--------------ERSFCTFSSN H-----GVCHALGTGSN-------ID----TFELVLQGTKCEEGKVCMDGSCQDLR------------------VYR--S ENCSAKCNNH--------------------------------GVCNHKRECHCH-KGWAP-PNCVQRLADVSDEQAA--- ----------------------STSLPVSVVVVLVILV---------------AAMVIVAG----IVIYR---------- -------------------------------------------------------------------------------- --------------------------KAPRQIQRRSVAPKPISGLSNP-------------------------------- ----------------LFYTRD-SSLPAKNRPPDPSETVSTNQPP--------------RPIVKPKRPPPAPPGAVS--- -SSPLPVPVYAPKIPNQFRPDP---------------------------------------------------------- ------------PTKPLPELKP---KQVKPTFAPPTPPVKP-------GTGG---------------------------- -----------------------------------------------------TVPG-ATQGAGEPKVALKVPIQKR--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Rattus_norvegicus_ADAM8 --------------------------------------------------------------------------MLGLWL LSILWTPAVAPGPPLPHVKQYEVVWPRRLAASR-------------SRRSLPSQWGLYPESLSYALGTSEQVFTLHLRKN RDLLGSSYTETYSAANGSEVKEQLH-----EQDH-CLYQGHVEGYEGSAASISTCAGL--S-GFFRVGSTVHLIEPLDA- DE--------------EGQHAVYQAKHLEQKA--GTCGVSETSLD-K------LG-------------------PRTLEI YR-----A--QPGNWLKPREIRYVELYVVADSQEFQKLGT-REAVRQR------VLEVVNHVDKLYRELSFRVVLVGLEI WNK-DKFYIS--RYANVTLENFLSWREQNLLGRHP-HDNVQLITGVDFIG------TTVGLAKVSALCSRHS-GAVNQDH TR-SAIGVASTMAHELGHNLGMNHDENIPGCYCPIPREGGGCIMTESI--------GSKFPKTFSR-CSQVDLESFVT-- NHQTGCLTNVPDVNR-FVGGP-VCG--NLFVERGE--QCDCG-TPQ---DCQNPCCNATTCQLAKGAECA-HGACCHECK -----VKPAGELCR-PMKDKCDLEEFCDGQKPTCPEDAFQQNGTPCPG-----G--YCFDGSCPTLAQQCQALWGPG--- -ARAASDSCFAFSIPQGCYG-----------SMYPSR--INRCGVLFCEG-GQKPL--------------ERSSCTFSSH H-----GLCQALQTDSN-------TN----TYEFVLQGTKCEEGKVCMDGNCQDLR------------------VYR--S ENCSAKCNNH--------------------------------GVCNHKRECHCH-AGWAP-PYCAQLLADVPGEQAA--- ----------------------SESLPVSVVVVLVILV---------------AAVVIGAG----IVIYR---------- -------------------------------------------------------------------------------- --------------------------KAPKQIQRRSVAPKPTSGLSNP-------------------------------- ----------------LFYTGD-SSLPAKSRPPDPPEMVSTNQPP--------------RPIVKPKRPPPAPPGAMS--- -SPPLPVPVYAPKAPNQLRPDP---------------------------------------------------------- ------------PTKPLPKLKP---KQVKPTFAPPTPPVKP-------GTGG---------------------------- -----------------------------------------------------TVPG-VTQGAGGSKVALKVPIQKR--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Bos_taurus_ADAM8 ---------------------------------------------------------------------------LGLLL FAALGLQEVAPRAALPHVEQYEVVRPRRLPAPR-------------ARRALPSHLGLYPESVSYVLGARGHTFTLHLRKN RDLVGSGYVETYTAANGSQVTEQLQ-----RQDH-CFYQGHVEGHPHSAASLSTCAGL--R-GFFQAGPAVRLIEPLAEA GE--------------EGPHALYLAQHLQQEA--GTCGVNDSSLESI------LG-------------------PRVSAA F---------RPRKWSEPRETRYVELFVVTDSKEFQRFGS-REAVRQR------VLEVVNHVDKLYQELNFRVVLVGLEM WNGGDKIQIS--SQPDATLDNFLAWRTRELVGRQA-HDNVQLITGVDFTG------TTVGLAKVSTMCSSSS-GAVNQDH SQ-NPIGVASTMAHEMGHNLGMDHDENVAGCYCPVPREGGGCVMAASI--------GSQYPRKFSQ-CSQADLETFVE-- NPRTACLLDAPDLDR-LVGGP-VCG--NGFLERGE--QCDCG-RPE---DCQNRCCNASTCLLAEGAECA-HGTCCHECR -----VKPAGELCR-PVKDQCDLGEHCDGQQPTCPEDAFRENGTPCPG-----G--YCYNGACPTLARRCQDLWGPG--- -SRVAVETCFLYSISKGCGAGV---------PLPFGR--VNKCGTLFCEG-GQKTP--------------ERGYCTLTIS S-----GVCRVIVQDGS-------T-----EYEPVPKGTKCGEQQVCWDGFCQGLH------------------VYR--S RNCSAQCNSH--------------------------------GECNHKGQCHCR-PGWAP-PHCAEPLADARAAPTA--- ----------------------PGSLRTHVLVGVGALV---------------VLALILAG----VLIYR---------- -------------------------------------------------------------------------------- --------------------------KARSPVRRRNVAPKTAMGLSNP-------------------------------- ----------------LFHEG--LSKPAKGGAQAPPGGSPELALYSQPHKP-------TASSVTPKRPPPAPPAAKA--- -SPPSPLPVYPPQAPGQLRPAP---------------------------------------------------------- ------------PAKPLPVLKP--KQVIKPTCAPPMPPIKP-------GARG---------------------------- -----------------------------------------------------AQPG-PTQGAADPKVALKPPVQRR--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Gallus_gallus_ADAM8 ------------------------------------------------------------------------PVGTWHVP LLGSPGVGAGLREELAHVERYETTVPRRVPSPR-------------AKRDLSVSTSTYPEHVLYSVCAEGRDYLLHLEKN RELLGQRYTETHYLADGTEVTVKPD-----VQDH-CFYQGHVEGHANSAASISTCSGL--S-GFFRVNETVFLLKPLDE- HE--------------AGQHAVYRASHLRMKR--SACLEAALEYD--------HD-------------------PKIAAP LKL----Y--HWKSARLHRGPRYVELVLVVDNEEFRKYKD-LRRVQNR------MKEIVNHVDKLYQSLGLRVALIGLEV WSNRDKITVS--RKAEETLENFLRWREMDLLKRKQ-HDNVQLITGIDFHD------TTVGLAKKLAMCTRDS-GGVNQDH SV-DPIGAASTLAHEMGHNLGMSHDEDIADCRCPVSKERGGCVMAAKI--------SSAYPRLFST-CSEQDMWQFLE-- DPKTSCLLNVPGADE-LYGEP-VCG--NQFVERGE--ECDCG-RPE---ECSDRCCNATTCRLREGAECA-RGDCCQDCK -----VKAAGVLCR-ASKNDCDLPERCTGLSSECPEDVFQENGIPCQG-----GRGYCYNGACPSHAEQCRLLWGAG--- -STASHPTRCNPVPHP------------------WRW--DVKCGTLLCMSDASSPAL-------------GSGFLTLSFG H-----YKCKAALDSND-------DNEMTGSLQLVPTGTKCGEEMVCYAGRCQNLL------------------VYG--K KNCSAKCSGH--------------------------------GVCNHKRECHCE-LGWAP-PYCQHKVLELTAGA----- ------------------------SSMVLAAVLAVLVL---------------SSILIGGG----FVLLRG--------- -------------------------------------------------------------------------------- --------------------------KGKKYFQKGRISSRPTTGLTNP-------------------------------- ----------------LFQEGARPHQLSLRAIGSPSLLSTTAAPR-------------DARPLVPGCPLLQDSSSAP--- --KPGHCPMLRSLPGPQEKPKP---------------------------------------------------------- ------------PTKPLPALKT---KQVAGEALPPTPPAKPPALSFQP-------------------------------- -----------------------------------------------------RAIPVLPQRGVPPKLALKPPASRR--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Danio_rerio_ADAM8_a ----------------------------------------------------------------------MRYTG--LFI TLLSFVYTWESLEALPHVMRYDVVRLQALRGRTR------------R--SASS-LQKYPEQLEYDVAIDGRNLTISLHRN RELLGKQYTLTHYGEDGISETKSSN-----KFNH-CYYHGHIHNFEDSSVSVGLCSGM--E-GFLRVNDQVYLIEPLEES LD---------------GDHAIYKQEHLRTKR--GAYGYIN-DTVYD------LG-------------------PKSSGL YK----GK--NMRNKAPRGGQQIVEMVLVVDNTEYKKFGS-FKKIEER------MMLVANHVDKLYRPLNIRVMLVGLEV WSQRDLIDVS--SRPNLTLERFLKWRRDSLLQRKK-HDNAHFITGIDFEG------STVGLATLYAMCSSSSSGAVNEDH NS-NPIAVASTVAHEMGHNLGMSHDD--SSCGCS---SNKGCIMGDTI--------GSIYPDSFST-CSQSSLKAFLE-- NYDTNCLIDVPNEGQ-IYGGP-VCG--NAFVEKGE--ECDCG-TVE---ECNNPCCNATTCRLTEGARCA-HGECCHNCQ -----LKHTGSLCR-KSAHDCDLDEYCTGESAFCPEDDYKMNGLPCNY-----NQGYCYNGQCPTHKEHCKMLWGSG--- -ADVDDDACFQYN-----VIDR---------TSKSAE--HRKCGRIYCYGGNPFPKT-------------NKKANVNVQS ---------RTCYMALD-------SSP-TEDLGMVPTGTKCGTNKVCYKSLCLDIS------------------MYG-TE N-CSNKCNNR--------------------------------GVCNHELKCHCD-PGWAP-PYCDIQLSELH-------- ----------------------KMRKSVVIGVTTSLAI---------------LVLIIIIGALVYNRNKIT--------- -------------------------------------------------------------------------------- --------------------------EFRKKRPQK-GIHSSS-GQCNP-------------------------------- ----------------AFQPGSAKNSPRIAQPRISQPTFLESSATQACKPLRS----AAMPCRPAPMPPKNAPQTRN-EQ IMKPPVPPSAISKNIYPPQ------------------------------------------------------------- -------------------------AKPLLPAAKPLPPSRP--------------------------------------- ------------------------------------------------------LPPLASKAVTKSKSPPVPPVKP---S GPQPVFTPPQVIQKVALKPPAWPR-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Danio_rerio_ADAM8_b --------------------------------------------------------------------MPCPAFTAHILC WLCLCGCVAESIRTLPHVERFDVVRPKRLNLSKV------------QSDKNPPSHEKYPDRLAYKLFFEGENHVIHLEKN KQLVGHNYTEIYYQDDGSIVSRNPS-----FKDN-CYYHGHIQDMEYSSVSVGICSGI--R-GFVRVKQQVYLIEPLANH SD---------------GDHALYKHQHLRRR-----RSSAGEPKTMF------YD-------------------HEPQVS --AALKSS--RWNMKSFQTP-RFVELFLVVDNTEYRNFGSSMDSIRAR------MLEVVNHVDKLYRSLNIRVMLVGLEV WMKQDQIVVS--VSSDDTLSRFIEWRKSNLLKRVK-HDNAQFVTGIDFLG------DTVGLANKFAMCAESS-AGVNQDH NQ-NPLGLASTIAHEMGHNMGMSHDE--DHCTCGSSVISSFCIMTERVGT--------LFPEQFSD-CSLEQLTVFLD-- NANPSCLLDTPSSYK-LYSGP-VCG--NAFLDPGE--ECDCG-SVE---ECKNPCCDPMTCKLTEGSRCA-QGDCCENCQ -----IKDAESLCR-ASINECDVPEYCTGLSEKCPENDFRMNGIPCSS-----GQGYCYNGQCPTHLQHCQRLWGTG--- -AKVAPDTCFYQNTLGKNDSHCGKT--KDGIRPCARE--NMFCGKIFCNEGNEFPVT-------------GQKAVIVTLR ---------GQCNVAGD-------QTE-EDALSMVPTGTKCGHNKVCYDYKCQELN------------------IYG-SI EGCSLQCNGR--------------------------------GICNHKKQCHCD-PGWAP-PYCNVKYSELS-------- ----------------------SAKT---IGISVAVAV---------------AVLVVIC------GAVLY--------- -------------------------------------------------------------------------------- --------------------------HKKRKAIS--RHKTQT--PTSG-------------------------------- ----------------QTSLLFENNSAQKDRPEISQPIFMGTTVSQPCTPLTA----RVGPTRPAPLPPKKPPS----QP QQTTVTQGTKLPAP------------------------------------------------------------------ --------------------------PVPPVKPSLATGSWR--------------------------------------- ------------------------------------------------------NDHVTEDTVKVVLK---PPIMPRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Takifugu_rubripes_ADAM8_b ----------------------------------------------------------------------MTHSGCFLLV FFISWGITAGSVEPLPHVKKYQTVIPQRLKVSSP------------IHDAAAA-HQTFPDVLRYSVTFAEQNHTLHLEKN KDLVGGSFTVTHFTDEGTRVSTAPD-----LWDH-CYYHGRVVGVDDSSASVGLCSGI--K-GFVRIQDQVYLIEPLADA EADVQGAKHSSEMPSDGGLHAVYNYKHLRRKR--SSCSHGNGTTFYD------HG-------------------AHPSAL FQ----KS--RGQTRERAGKPRTVEMVVVVDHTEYKKFGS-IKKVQSR------VLEAANHVDKLYRPVGIRVMLVGLDI WSNRDQIDVS--SDSELTLGRFLKWRQWKLLPDIK-HDNAQFITGVDFDG------STVGLANTNSMCTSNS-GAVNEDH NP-NPIGVASTIAHEMGHNLGLSHDK--ENCVCGSQATKRGCIMSESL--------GIVYPEQFSS-CSQQQLSTFLE-- EINPACLLDTPSTNR-LYGGP-VCG--NAFLEAGE--ECDCG-TVE---ECTNPCCNATTCKLAAGARCA-AGECCHGCQ -----LKPTGSVCR-EKSGDCDLEEFCTGFSASCPTDAFTQNGLTCNR-----GRGYCYNGQCPSRLQHCRRLWGPG--- -KSPANVLFRLIV------LLF---------VLFGGR--DQSCGKLFCSGGWEFPIT-------------SKKFFYTLGN G-----NLCNEAVMNSD-------DNF-PQDLAMVPTGTKCGTNMVCYNQRCQDIKSIK---------------TYG-TN D-CAGKCSNR--------------------------------GVCNHENKCHCD-PGWAP-PYCDVLLPELP-------- ----------------------EETGSMVVMVSLVT-S---------------LLLLVLV-----VGGSIC--------- -------------------------------------------------------------------------------- --------------------------CIKKTRPVKRCLRSAASGRSNP-------------------------------- ----------------LFQPGSARGSPSLGPTHISQPIFVESSATRACKPLSS----SRPTTA-APKPSRAAPEDYCLFF FLNPLQPPKNFKPAARPPQ------------------------------------------------------------- ------------------------YQQPFPTQGKPLPPSRP--------------------------------------- ------------------------------------------------------LPPLASKPVTKPK-LPVPPVKPKPSA VPSSLPHTQLLAERAALMPPNRPR-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_ADAM8_b ----------------------------------------------------------------------MADLGHFLFM LLVSWGTTS--AEPLPHVKKYQTVIPQRLEDPSP------------S-DDAAA-HRTFPDVLRFSLTITEQNYTLHLEKN KHLVGGSFTVTHFSDQGARVTTAPD-----LRDH-CYYHGHVVGVEDSSASVGLCSGI--R-GFVHVHGQIYLIEPLAEA ET-------------DGGLHAVYNYKHLRRKR--SSCSHGNQTSYYD------HV-------------------PGPSGL FQLASLKR--RGQSGERVGKPRTVELVVVVDHTEYKKIGS-TKMVESR------VLEVANHVDKLYRPVGIRVMLVGLEI WSYRDLIDVS--SDPELTLGRFLKWRQWSLLPRTK-HDNAQLITGVDFDG------STVGLANTNTMCTSNS-GAVNEDH NK-SPVGVASTIAHEMGHNLGLSHDV--ENCVCGSQTTKRGCIMSESVGEA-----GLSIQGSSAA-GSQQQLSTFLE-- EITPACLLDSPSTSR-IYGGP-VCG--NAFVEAGE--ECDCG-TAK---ECRNPCCNATTCKLAAGAQCA-AGECCHRCQ -----LKATGSVCR-PKSGDCDLEEYCTGFSASCPRDAFTSNGLACNR-----GAGYCYNGQCPSHQQHCRRLWGPE--- -AKMAVEACYLQHGNCRKTLFN---------QKCSRR--DQFCGKLLCSDGWEFPVT-------------SKKFLYPLGN G-----KQCNEAGMNSE-------DNY-PPDLAMVPTGTKCGPNMVCYNQRCQDMKSVK---------------PYA-TS D-CSSKCNNR--------------------------------GVCNHENKCHCD-PGWAP-PYCDVLLSELP-------- ----------------------RETGSVVLPVSLAVGF---------------LLLLVLV-----FGGLMC--------- -------------------------------------------------------------------------------- --------------------------YIKKRPPVKRCLQSAS-GQSNP-------------------------------- ----------------LFRSGSARGSPRLGPAHIGQPVFVESSATQACKPLFS----SRATTA-APKPSRAAPEP---PK NPKPVAQPSQVQQVPRPPSSVG---------------------------------------------------------- ------------AEVS-------CCMQSLAPQKKPLPPSRP--------------------------------------- ------------------------------------------------------LPPVASKPVVKSK-PPVPPVKPKPSA YASSLPHTQLLAGRAALMPPNRPR-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_ADAM8_a ----------------------------------------------------------------------MPDSGSFVWI SLSLWGSVR----TLPHVIKYQTVTPQRLWDPS-------------APDAAT--HQTYPDVLQYSLTIAGRNYTLHLERN KDLVGKKFSVTHYSDQGTQVTTTPD-----LTAH-CYYHGHIVGVEDSSASVGLCSGINCR-GFVRLRDQMYLLEPLAGT DE---------------GLHAVYNYKHLRRKR--SSCSHGNTTTFYD------HG-------------------AHPSGL FQLGSLKS--RAQTKDPAGKPKTVELVVVVDNAEYKKFGS-RKTVEAR------ALEIANHVDKLYRPVGVRVMMVGLDI WSYKDQIEVS--ADPELTLSRFLEWRQRSLLQRTK-HDNAQFITGVDFIG------STVGLANTNAMCTSNS-GAVNEDH NS-NSIGVASTIAHEMGHNLGLSHDA--ENCVCGSPTSKRGCIMAERV--------GLVYPELFSS-CSQQQLSRFLE-- EINPACLLDTPAADR-NYGGP-VCG--NSFLEPGE--ECDCG-TVE---ECKNPCCNATSCKLNAGAQCA-EGKCCHECQ -----LKPTGSVCR-PKAGNCDLAEYCTGFSASCPTDAYTQNGLSCNR-----GKGYCYNGRCPSQREHCKRLWGPD--- -ADVASDACFYTHGN--CKRT-----------LFSQR--DQHCGTLFCSGGWEFPVT-------------SRKSFYRVGN G-----DICNTATMIPE-------DNY-PADLGMVPVGTKCGNNMVCYNQRCQDIQNIN---------------TYG-KS D-CSAKCNHH--------------------------------GVCNHESKCHCD-PGWAP-PFCNVEQSELPEGILS--- ----------------------QSVCVCVCAQMQVVGL---------------LLLLVLV-----IGSLMC--------- -------------------------------------------------------------------------------- --------------------------CIKKRRPAKRCLQANS-GQSNP-------------------------------- ----------------LFRSSGTRGSPRLGSTHISRPIFVESTAS---KPLSS----ARPHAG-VLTPCRAAPVP---PK KLSALPQPMKIQQAVRSFMQP----------------------------------------------------------- -----------------------VSSKPVYTENKPLPPSRP--------------------------------------- ------------------------------------------------------LPPLATKPIMKPT-PPMPPVKPKPSA ARCPLPHTQ-LVWRAALTPPCRPR-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_ADAM8_b -------------------------------------------------------------------------------- --------------LSHVEKYEVVRPQRLQG---------------RPQRSPQDPQLHPDAVQYELTVEGTKHTILLEKN RNLIGRGFTETRYSQDGKRMTTSP------KEEL-CFYHGHIRGLEDSSVSVGICSGI--S-GLLRLRQQVFLIEPLGRA AD---------------GDHALFRREHLKLGGPFACGSSPNGTTRHN------PD-------------------RDPGPR LSGLFRSR--SWKTKAVAGPQKFVELFVVVDNAEYKRYG---DQTKSR------ILEVINHVDKLYRPLNIRVVLVGLEI WTDGDHIDVD--VKSETTLDNFLLWRRADLLRRTD-HDNAQFVTGKDFDG------DTVGLANKFAMCTENS-GGVNQDH HD-NPIGLASTIAHEMGHNFGLSHDA--AGCLCGPSHSSGTCVMAEKLRTG-----SQAFPELFSG-CSVEQLADFME-- RARPGCLR-PPGSARSVAAGP-RCG--DALLDPGE--ECDCG-TVE---ECKNRCCDASTCLLTGGSQCA-HGQCCDNCQ -----LKPAGSVCR-EKASECDLSEFCTGASSDCPEDAFQMDGKPCFDQ----GEGFCHSGRCPTHQQHCWRLFGKG--- -ATVGPPECFGLNRRGENKT----------VQVLFYR--NLLCGSMFCGGGGES-IS-------------GKMAVYKVYG ---------IECKLAVD-------DDR-TRSLDMVPRGTRCGGNKVCLDRQCVDAS------------------AYG-RP EECAKKCNNN--------------------------------GVCNHKKECHCD-PGWAP-PHCDIQYADLP-------- ----------------------QGHSGIIAGVCAAVSI---------------LLLISAL------TAGLL--------- -------------------------------------------------------------------------------- --------------------------CCKKDDMDNYASKRKV--HSAP-------------------------------- ----------------DRPDRVFQEQGVSGRPQISPPTFMASTATQACAPLMV----SAPPRAAAPQVPTRRGSTG--EP QKAPPPKPPKAPPP------------------------------------------------------------------ --------------------------APPPAQTKPVPPSKP--------------------------------------- ------------------------------------------------------LPPLSKTRVSHLMSGPAPPLLPAEP- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Oryzias_latipes_ADAM8_b --------------------------------------------------------------------FKQNTLYVLLFI RLYLWCSKK----TLPHVSKYQTVVPQRLKDLST------------IKDTAP--HEKYPDVLQYSLSIDRGKYTLHLEKN RYLVGKNFTVTSYSDDGAQVTSTPD-----LRVH-CYYHGHIVGVEESSASIELCSGM--K-GFVTLRNRMYLIEPLASD DE---------------GPHAVYNYKHLRRKR--SSCSHGNTTTFYD------HG-------------------ARPSGV FQLGSLKS--RAQTKQQADKPRTVELVVVVDNSEYKKYGS-KKTIESR------VLEIANHVDKLYRPVGVRVMLVGLII WSNRDQIEVS--SNSDTTLIRFIEWRQRNLVQKIK-HDNAQLITGIDFEG------TTVGLANTNAMCTSNS-GAINEDH NT-NAIGVASTIAHEMGHNLGLTHDT--ENCVCGSYTSKRGCIMAESL--------GIVYPEQFSS-CSKLQLRRFLE-- EYNPACLLDTPSTSR-IFGGP-VCG--NAFLEPGE--ECDCG-SAK---ECTNPCCNATTCKLNAGAQCA-EGECCHNCQ -----LKPTGIICR-PKAGDCDLAEYCTGFSAACPADTFAQNGLRCNS-----GKGYCYNGNCPSRQEHCRRLWGPD--- -AEVAADECFSRHGS--CRKFS---------QRCAAK--DQFCGTLFCSGGWTFPVT-------------SMKSYYIVGN G-----VTCNEATMKPE-------DNY-PSDLGMVPTGTKCGNNMVCYNNRCEDIRNIK---------------AYG-KN D-CSSKCNNH--------------------------------GVCNHESKCHCD-PGWAP-PFCDVQQSE-----LT--- ----------------------QDSAPVVVVVSVIIGL---------------LLLLVLV-----VVSLMC--------- -------------------------------------------------------------------------------- --------------------------YIRKRTPTKSRLTT-S-GQSNP-------------------------------- ----------------VFRSSGTRGGPPVGSKVISQPVFLESSATQACKPLSF----ALNRPDRDLKPCRAAPEP---PK YTQGIPQPTRKYQA---FMQPT---------------------------------------------------------- ------------A----------VSLLPIYNENKPQPPSRP--------------------------------------- ------------------------------------------------------LPPLTAKPIMKPK-LPTPPVKPKPTA ALSSLPHTQ-IGKRAVLMPPSRPR-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Homo_sapiens_ADAM9 ------------------------------------------------------------MGSGARFPSGTLRVRWLL-- -LLGLVGPVLGAARPGFQQTSHLSSYEIITP-WRLT----------RERREAPRPYSKQ--VSYVIQAEGKEHIIHLERN K-DLLPEDFVVYTYNKEGTLITD-----HPNIQNHCHYRGYVEGVHNSSIALSDCFG---LRGLLHLENASYGIEPLQN- --------------SSHFEHIIYRMDDVYK--EPLKCGVSNKDIEKETAKDEEEE-------------------PP---- SMTQLLR-----RRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREE------MILLANYLDSMYIMLNIRIVLVGLEI WTNGNLINIVG--GAGDVLGNFVQWREKFLITRRR-HDSAQLVLK---KGF----GGTAGMAFVGTVCSRSHAGGINVFG QI-TVETFASIVAHELGHNLGMNHDDGRDCSCG------AKSCIMNSGAS---------GSRNFSS-CSAEDFEKLTL-- NKGGNCLLNIPKPDEAYSAP--SCG--NKLVDAGE--ECDCGTPKE---CELDPCCEGSTCKLKSFAECA-YGDCCKDCR -----FLPGGTLCRGKTSE-CDVPEYCNGSSQFCQPDVFIQNGYPCQNN-----KAYCYNGMCQYYDAQCQVIFGSK--- -AKAAPKDCFIEVNSKGDRFGNCG--FSGNEYKKCATG-NALCGKLQCENVQEI-PVF-----GIVPAIIQTPSRGTK-- --------CWGVDFQLGSD---------VPDPGMVNEGTKCGAGKICRNFQCVDASVL-----------------N--YD CDVQKKCHGH--------------------------------GVCNSNKNCHCE-NGWAP-PNCETKGYGGSVDSGP--- ----------------------TYN--EMNTALRDGLL---------------VFFFLIVPLIVCAIFIFIKRDQL---- ------WRSYFRKKRSQTYESDGKNQAN-----------------------PSRQP------------------------ -------------------------------------------------------------------------------- ----------------------GSVPRH-VSPVTPPRE------------------------VPIYANRFAVPTYAAKQP QQ--FPSRPPPPQPKVSSQGN----------------------------------------------------------- ------------LIPARPAPAPP--LYSSLT------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Pan_troglodytes_ADAM9 ------------------------------------------------------------MGSGARFPSGTLRVRWLL-- -LLGLVGPVLGAARPGFQQTSHLSSYEIITP-WRLT----------RERREAPRPYSKQ--VSYVIRAEGKEHIIHLERN K-DLLPEDFVVYTYNKEGTLISD-----HPNIQNHCHYRGYVEGVHNSSIALSDCFG---LRGLLHLENASYGIEPLQN- --------------SSHFEHIIYRMDDVYK--EPLKCGVSNKDIEKETAKDEEEE-------------------PP---- SMTQLLR-----RRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREE------MILLANYLDSMYIMLNIRIVLVGLEI WTNGNLINIVG--GAGDVLGNFVQWREKFLITRRR-HDSAQLVLK---KGF----GGTAGMAFVGTVCSRSHAGGINVFG QI-TVETFASIVAHELGHNLGMNHDDGRDCSCG------AKSCIMNSGAS---------GSRNFSS-CSAEDFEKLTL-- NKGGNCLLNIPKPDEAYSAP--SCG--NKLVDAGE--ECDCGTPKE---CELDPCCEGSTCKLKSFAECA-YGDCCKDCR -----FLPGGTLCRGKTSE-CDVPEYCNGSSQFCQPDVFIQNGYPCQNN-----KAYCYNGMCQYYDAQCQVIFGSK--- -AKAAPKDCFIEVNSKGDRFGNCG--FSGNEYKKCATG-NALCGKLQCENVQEI-PVF-----GIVPAIIQTPSRGTK-- --------CWGVDFQLGSD---------VPDPGMVNEGTKCGAGKICRNFQCVDASVL-----------------N--YD CDVQKKCHGH--------------------------------GVCNSNKNCHCE-NGWAP-PNCETKGYGGSVDSGP--- ----------------------TYN--EMNTALRDGLL---------------VFFFLIVPLIVCAIFIFIKRDQL---- ------WRSYFRKKRSQTYESDGKNQAN-----------------------PSRQP------------------------ -------------------------------------------------------------------------------- ----------------------GSVPRH-VSPVTPPRE------------------------VPIYANRFAVPTYAAKQP QQ--FPSRPPPPQPKVSSQGN----------------------------------------------------------- ------------LIPARPAPAPP--LYSSLT------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Mus_musculus_ADAM9 ------------------------------------------------------------MGPRALSPLASLRLRWLL-- -ACGLLGPVLEAGRPDLEQTVHLSSYEIITP-WRLT----------RERREALGPSSQQ--ISYVIQAQGKQHIIHLERN T-DLLPNDFVVYTYDKEGSLLSD-----HPNVQSHCHYRGYVEGVQNSAVAVSACFG---LRGLLHLENASFGIEPLHN- --------------SSHFEHIFYPMDGIHQ--EPLRCGVSNRDTEKEGTQGDEEE-------------------HP---- SVTQLLR-----RRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREE------MIRLANYLDSMYIMLNIRIVLVGLEI WTDRNPINIIG--GAGDVLGNFVQWREKFLITRWR-HDSAQLVLK---KGF----GGTAGMAFVGTVCSRSHAGGINVFG QI-TVETFASIVAHELGHNLGMNHDDGRECFCG------AKSCIMNSGAS---------GSRNFSS-CSAEDFEKLTL-- NKGGSCLLNIPKPDEAYSAP--SCG--NKLVDPGE--ECDCGTAKE---CEVDPCCEGSTCKLKSFAECA-YGDCCKDCQ -----FLPGGSMCRGKTSE-CDVPEYCNGSSQFCPPDVFIQNGYPCQNS-----KAYCYNGMCQYYDAQCQVIFGSK--- -AKAAPRDCFIEVNSKGDRFGNCG--FSGSEYKKCATG-NALCGKLQCENVQDM-PVF-----GIVPAIIQTPSRGTK-- --------CWGVDFQLGSD---------VPDPGMVNEGTKCDAGKICRNFQCVNASVL-----------------N--YD CDIQGKCHGH--------------------------------GVCNSNKNCHCE-DGWAP-PHCDTKGYGGSVDSGP--- ----------------------TYN--AKSTALRDGLL---------------VFFFLIVPLVAAAIFLFIKRDEL---- ------RKT-FRKKRSQM--SDGRNQAN-----------------------VSRQPGDP--------------------- -------------------------------------------------------------------------------- ---------------------SISRPPGGPNVSRPPGGPGVSRPPGGPGVSRPPGGPGVSRPPPGHGNRFPVPTYAAKQP AQ--FPSRPPPPQPKISSQGN----------------------------------------------------------- ------------LIPARPAPAPP--LYSSLT------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Rattus_norvegicus_ADAM9 ------------------------------------------------------------MGPRALSPLASLRLRWLL-- -ACGLLGPVLEAGRPDSEQTVHLSSYEIVTP-WRLS----------RERREALRPSSKQ--ISYVIQAQGKQHIIHLERN T-DLLPNDFVVYTYDEEGSLLSD-----HPNVQSHCHYRGYVEGVPNSTVAVSACFG---LRGLLHLENASFGIEPLHN- --------------SSHFEHVFYPMDDVHQ--EPLRCGVSNRDTEQEATQGEEEE-------------------HP---- SVTQLLR-----RRRAVLPQTRYVELFIVVDKERYNMMGRNQTAVREE------MIRLANYLDSMYIMLNIRIVLVGLEI WTDRNPINIIG--GAGDVLGNFVQWREKFLITRRR-HDSAQLVLK---KGF----GGTAGMAFVGTVCSRSHAGGINVFG QI-TVETFASIVAHELGHNLGMNHDDGRECFCA------AKSCIMNSGAS---------GSRNFSS-CSAEDFEKLTL-- NKGGSCLLNIPKPDEAYSAP--SCG--NKLVDPGE--ECDCGTPKE---CELDPCCEGSTCKLKSFAECA-YGDCCKDCQ -----FLPGGSMCRGKTSE-CDVPEYCNGSSQFCPPDVFIQNGYPCWNS-----KAYCYNGVCQYYDAQCQVIFGSK--- -AKAAPRDCFIEVNSKGDRFGNCG--VSGSNYKTCATG-NALCGKLQCENVQEM-PVF-----GIVPAIIQTPSRGTK-- --------CWGVDFQLGSD---------VPDPGMVNEGTKCDAGKICRNFQCVNASVL-----------------N--YD CDIQGKCHGH--------------------------------GVCNSNKNCHCE-DGWAP-PHCDTKGYGGSVDSGP--- ----------------------TYN--AKSTALRDGLL---------------VFFFLIIPLVAAAFFLFIKRDEL---- ------RKT-FRKKRSQM--SDGRNQAN-----------------------ASRPPGDP--------------------- -------------------------------------------------------------------------------- ---------------------SVSRPPGGPSVSRPPGGPNVSRPPGGPNVSRPPGGPSVSRPPPVHGNRFPVPTYAIKQP PQ--FPSRPPPPQPKIPSQGN----------------------------------------------------------- ------------LIPARPAPAPP--LYSSLT------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Canis_familiaris_ADAM9 ------------------------------------------------------------MGSGAGSPFGVFRLQWLL-- -LFGTVGPVLGGARPGFQQTSHLSSYEIITP-WRLT----------RERREAPRPYSEQ--VSYIIQAEGKEHIIHLERN K-GFLPRDFVVYTYNKEGALISD-----HPDVQNHCHYRGYVEGISNSSIALSDCFG---LRGLLHIENVSYGIEPLQN- --------------SSHFEHIFYRMDDVHK--EPLKCGVSNKDMEKETTNYEEEE-------------------PL---- SVTQLLR-----RRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREE------MIRLANYLDSMYIMLNIRIVLVGLEI WTNGNLINIIG--GAGDVLGNFVQWREKFLITRRR-HDSAQLVLK---KGF----GGTAGMAFVGTVCSRSHAGGINVFG QI-TVETFASIVAHELGHNLGMNHDDGRDCFCG------AKSCIMNSGAS---------GSRNFSS-CSAEDFEKLTL-- NKGGNCLLNIPKPDEAYSAP--FCG--NKLVDPGE--ECDCGTPKE---CESDPCCEGTTCKLKSSAECA-YGDCCKDCW -----FLPGGTLCRGKTNE-CDVPEYCNGSSQFCQPDVFIQNGYPCQNN-----KAYCYNGMCQYYDAQCQVIFGSK--- -AKAAPRDCFIDVNSKGDRFGNCG--FSGNEYKKCATG-NALCGKLQCENVQDM-PVF-----GIVPAIIQTPSKGTK-- --------CWGVDFQLGSD---------VPDPGMVNEGTRCDNGKICRNFQCVNASVL-----------------N--YD CDIQKKCHGH--------------------------------GVCNSNKNCHCE-NGWAP-PNCETKGYGGSVDSGP--- ----------------------TYN--EKNTALRDGLL---------------VFFFLIVPLIVCAAFVFIKRDQL---- ------WRSYFQKKRSQT--SDGKNQAK-----------------------ASRQP------------------------ -------------------------------------------------------------------------------- ----------------------VSVPRH-VSSVTPPSGSSVF-TMPVGTKQVWRYIFGRFLFKPIYANRFPVPTYAAKQP QQ--FPSRPPPPQPKVSSQGN----------------------------------------------------------- ------------LIPARPAPAPP--LYSSLT------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Monodelphis_domestica_ADAM9 -------------------------------------------------------------------------------- ---------------DFQQTSLLSSYEIITP-WRLV----------RERREAPRPYSAQ--VSYVIQAEGRKHVVHLERN K-ILLPKDFVIYTYSEEGSLLLD-----HPDMQDHCHYHGYVEGVPNSAVALSICSG---LRGLLHLENTSYGIEPLKS- --------------SSDFEHLIYRLDNVQQ--EPLACGVTAKDLKKETTEDEKKE-------------------LQKQSL SMTQLLR-----KKRAVLPHTRYVELFIVVDKEKYDMMGSNQTAVREE------MVQLANYLDSMYIMLNIHIVLVGLEI WTNSNQISIAG--SAGDVLGNFVQWREKSLISRRR-HDSAQLVLR---KGF----GGTAGMAFVGTVCSRSHAGGINVFG QI-SVETFASIVAHELGHNLGMNHDDGRNCTCG------AKSCIMNSGAS---------GSRNFSS-CSADDFENLTL-- NKGGTCLLNIPKPDEAYSAP--YCG--NKLLDVGE--ECDCGSPKE---CELDPCCEPSTCKLKSGAECA-YGDCCKNCR -----FLPGGTLCRPSANE-CDLPEYCNGSSQFCQLDVYIQNGYPCHKN-----KAYCYSGMCQFYDAQCQVIFGSK--- -AKAAPRDCFIDVNSKGDRFGNCG--HNGNEYRKCSTG-NALCGKLQCENVQGM-PVF-----GILPALIQTVFGGTT-- --------CWGVDFQLGSD---------VPDPGMVNEGTKCDHGKICRNFQCVNASVL-----------------N--YD CDTQKKCSGR--------------------------------GVCNNNKNCHCN-MGWAP-PNCENTGYGGSVDSGP--- ----------------------TYN--GKNTSLRDGLL---------------VFFFLIVPLLVFAAFVFLKRDQL---- ------RRKFFRKKRSQTYHSRRRQVVLRPVG------------------ELARYPSPK--------------------- -------------------------------------------------------------------------------- ---------------------YVKTSPGEMSGSDGKNQTNVS---------RQPANAPRNAPPAIYANRFPVPTYAAKQP QQ--FPSRPPPPQPKVLSQGN----------------------------------------------------------- ------------FIPTRPAPAAP--VKGLL-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Gallus_gallus_ADAM9 -------------------------------------------------------------------------------- ---------------GFQEISQLSSYEVIIP-QKLG----------RERRETSNASSTQDKVSYAIEIEGKEYTIHLEKN K-DLLPKDFTVYTYNKEGKLQSE-----YPDVQDHCYYQGYVEGILDSVVAVSTCSG---LRGLVTIGNVTYGIEPMDS- --------------SSGSEHIVYSLDNVKK--EPSMCGVMTEGHEE-GEHTGENH-------------------HP---- SMTQLLR-----KKRAILHQTRYVELFIVVDKEKFEDFGKSETEVREH------MVQLANFLDSMYIMLNIHIVLVGLEI WKYENIISTDG--GAGDVLANFVQWREKNLVLRRR-HDSAQFVLK---KGF----GGTAGMAYVGTVCSKSHAGGINVFG KI-SIQMFASIMAHELGHNLGMNHDDERVCHCG------ASSCIMSSGAS---------GSRNFSS-CSAEDFEKLTL-- NKGGSCLLNVPRPDETYSIP--YCG--NKLVDMGE--ECDCGSPKE---CENDPCCEPGTCRLRPTAECA-YGDCCKNCR -----ILPGGTECRASNNE-CDLPEYCNGTSQFCQPDFTVQNGHPCHNE-----EAYCYNGVCQYYDAQCQDIFGSK--- -AKAAPNICFAKVNSKGDRFGNCG--FHGHDYKKCSSW-NAMCGKLQCENVETM-PVF-----GIKPAIIRTPSDGTT-- --------CWGVDFQLGSD---------VPDPGMVNEGTKCDNGKVCRHFQCVSASVL-----------------N--YD CDVEKQCHGH--------------------------------GVCNNNRNCHCE-PGWAP-PFCNTKGYGGSIDSGP--- ----------------------PYN--DKDNSLRNGLL---------------VFFSWSYHSL----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Anolis_carolinensis_ADAM9 -------------------------------------------------------------------------------- ------------------------------------------------------------MFLYVITIEGKDRTLVLERN E-VLLPKDFTMYTYKKDGTLHTE-----KPRIEDHCHYQGYVEGTSDSLVAVNICFG---LRGMIQIGNITFGVEPTHT- --------------G---KHVVYPLSSVKS--PFFSCGVHSLSHGCKSPAMFHSV-------------------ED---- -RTPHLR-----NKRGLLLQTRYVELFIVVDKERYMLLGQNKTAIREE------MMHLANYLDGMYATLNIRIVLVGLEI WTVQNKISLEG--GAADVLANFVQWRERDLILRRR-HDSAQLVMT---KGF----GDVAGMAYVGTICSKSNAGGINVFG PI-SVQMFASIVAHELGHNLGMNHDDERHCHCP------TDNCIMKSKAS---------GARNFSS-CSEEDFEKLTL-- NKGGSCLLNIPRPEETYSIP--YCG--NKLVDAGE--ECDCGSLEE---CKTDPCCEPGMCKLRPGAECG-YGDCCHNCH -----YMTKATECREKASE-CDLPEYCNGTSAFCPQDVTIQNGHPCKKG-----EAYCYNGVCQYYEAQCQAIFGPK--- -AKAAPEVCFSAVNSKGDRFGNCG--YHNYDYKKCSSS-NSMCGKLQCENVKTL-PVF-----GIEPAFIQSPIKGST-- --------CWGVDFQLGSD---------VPDPGMVNEGTKCAPGKICKHYQCVDVAVL-----------------G--YD CDINNQCNGQ--------------------------------GVCNSNKNCHCN-SGWGP-PFCNTKGYGGSVDSGP--- ----------------------PYN--DEDTTTRNWLL---------------AFFFLILPLLLSVVFCYFMRNRLGYSL RPLIECCCGCFRRSRRRRQEPVGSEFPPN------------------VPFPPMDTSSQM--------------------- -------------------------------------------------------------------------------- ---------------------NMQAKRYPVPSYTANQQPYG--------------------EHFYYAPPHSAPRSAALPT EQHYIPSRPPPPATKPTKTQEP---------------------------------------------------------- ------------LIPSRPAPLPPK-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Danio_rerio_ADAM9_a ------------------------------------------------------------MAHAVCSRLVKNAFMWIM-- ----LHTLVDCCGGSVTQQTSQLSSYEVTVP-RRIS----------RQRRNQDS--ADK--VSYIIQAQGKEHVVILERN E-LLLPEDFTVYSYAKDGSLVTE-----KLNTTDHCHYSGYIEDVEGSSAALSLCSG---LRGVIHTEGTSFGIEPLEG- --------------SSSDEHLVYRLEDVQT--QPLNCGTPHSYN-HDDQSSPRQP-------------------IISHTH NITFGQAGSHLRRKRAVLHQTHYVELLMVVDNERYNYKNRNHTAVREE------VVQIANYVDSMYIPLNIRIVLVGLEI WNMQNLINIDG--SAGEVLSRFTQWREKELVHRRR-HDSAQLILK---KGF----GGTAGMAFVGTACSRSHGGGINAFT NN-NVMSFASIVAHELGHNLGMNHDDGRNCKCD------VTHCIMNSGAT---------GSCNFSS-CSADDFEKMIL-- NSGGRCLLNIPRPDEAYSAP--FCG--NKLVDVGE--ECDCGSEEE---CEKDPCCEAKTCKLRSGAQCA-YGVCCKNCR -----FLPGGSVCRSSTDE-CDLAEYCNGSSALCQNDVFKQDGHPCKQD-----TAYCYNGQCQHYDTQCQNIFGKK--- -AKAAPELCFKDVNSKGDRFGNCG--YHSSGFKKCESR-NAMCGKLQCENVFSLSVIF-----GIKPARIETPIAGTT-- --------CWGVDFRLGSD---------VPDPGMVNEGTKCGDNKVCLNFECRSADVL-----------------N--YD CDVEKKCHGH--------------------------------GVCNSNKNCHCE-YGWAP-PFCEASGYGGSIDSGP--- ----------------------TWN--DKDTSLRDGLL---------------VFFFLVLPLLALGLYVFFKRNELK--- -----QRF--LRKKRSQAYEDESRPQAT-----------------------VSQRG------------------------ -------------------------------------------------------------------------------- ------------------------IPKSIVKDGHQTQLLPP--------------------EEVVYTNKSASVPSYATRP PP--------PPFTRPPAPHQQ---------------------------------------------------------- ------------PKPQRPAPAPP--V------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Danio_rerio_ADAM9_b ---------------------------------------------------------------------MTRHVNIFVLI LINFSICPVQAIDQTSYLKKYDVVKPQLVQMRWRRYA---------DPSHKQPEERHADI-ITYSVRIEGSDRILHVTKN T-DFLSKNFVVISHKTP-KKGKV-----QPERMVQCYYQGHVEGYEDSLVALSTCEG---IRGVIIIGNKSYGLEPVLH- --------------SKANEHLLFLLEDSHS--EPFVCGLENETSLS-EDHSRYAD-------------------MS---- MFL---------RKKRTLPQTKYVELALVVDQKRFIIKNRSVNAVRDE------MVQLANLLDTYFKQLNIRIALIGLKI FDTGNPFSVEG--NAGDVLGRFVDWRKTTLSPQIR-NDAAQLVVG-QGAYP----GGVLGMAFVGSVCSASTSGAISVFS DN-NLQYYSTVAAHELGHNLGMSHDSNGCSCQ----------CIMAPSAS---------GSTKFSD-CSDNAFERLIQ-- GGGGACLRNIPAQDSIISVP--RCG--NGILESGE--ECDCGTPQE---CNTT-CCNAATCTFTKGSTCA-AGSCCQKCQ -----IIVAGTPCRPSINP-CDLPEYCGGESPYCPSDFYMMDGLPCNNN-----AAYCFEGRCQTFDYQCKQIFGSG--- -ATKADDKCFTNVNTYGNAFGNCG--YSGTFPKPCSVQ-NAMCGKLQCL-FNSNNPPL-----GATVSVQK--IEGGTIT --------CMNADFNMGPD---------VPDPAYVKTGSVCAPGKLCANFTCFNSSVM-----------------DQSRK CDAQRDCSSN--------------------------------GVCNDRYHCHCN-NGWGP-PNCNKGGRGGSIDSGP--- ----------------------AEI----DYSLRNGLL---------------IFFLLVVPILVVLIIVLLYVFKRD--- ------SLKRFLKGCPSIRKRPTNAANGSSNT------------------------------------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------PSNVQANGNTTRASAPQSMTEIQ TAHQSQPTDPKYQQDTTVNQPR---------------------------------------------------------- ------------QGPGVPKPIPPRQTQVPV-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Takifugu_rubripes_ADAM9_b -------------------------------------------------------------------------------- ------------------QTQHLSSYQLTVP-RPVGG---------RFRREANGTLPSQ--VSYIIPVDGLDHIVHLQRN Q-LLLPADFTVFSYSQNGSLITS-----RPPVQNHCHYHGFVENMPESSVAMSICNG---LRGVLRLPDNSYGIEPLE-- --------------SDPNQHLLYRLQDVTS--QPQGCATSHGDR----HYDPTEE-------------------IPHTRQ HKR---------MKRAVLHQTHYVELLLVVDNDRFNYMNRNDTAVREE------MVHLANFIDSIYIQLNVRVVLVGLEI WTQQNLISTDG--GAGEVLSRFTQWREKALVPRRR-HDSAQLILK---KSF----GGTAGMAFVSTVCSRSHGGGINAFP NT-NLPAFASIVAHELGHNLGMNHDDGRSCTCP------TAACIMNSGTT---------ESRNFSS-CSADDFEKMIL-- LTGGTCLLNVPHPDEAYSSP--YCG--NRLVDVGE--ECDCGSQKE---CEKDPCCEYQTCKLKPGAQCA-YGECCSGCQ -----YLAGGTVCRSSTDE-CDLPEFCNGSSSLCQSDVFVQNGQPCRSQ-----QAYCYNGKCRHHDGQCQDIFGSK--- -AKASPEICFKDVNNKGDRFGNCG--YHNYGYKKCESR-NALCGKLQCSNIQTS-IVF-----GIQPSIISTSIGGAK-- --------CYGVDFRLGSD---------VPDPGMVNEGTKCGEDKVCVNFECRSADIL-----------------N--YD CDVEKKCHGH--------------------------------GVCNSNKNCHCD-DGWAP-PFCELQGYGGSVDSGP--- ----------------------TWN--DKDTSLRDGLL---------------VFFFLILPLLILTAFVYLRKNEFL--- -----RCLGLQRRKRSEAYQVDKATPVN-----------------------RSRGP------------------------ -------------------------------------------------------------------------------- ------------------------PPRVPPPVSLGNS------------------------DNVVETSRTA--PAFAPRP PP-------PPLKPKPPPASHP---------------------------------------------------------- ------------LVPQRPAPAPP--VYSSLS------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_ADAM9_b -------------------------------------------------------------------------------- -------------------------------------------------------------------VDGREHVVRLQRN R-LLLPADFTVFSYSQNGSLVTA-----RPPVQNHCHYQGFVENMLGSSVAMSICNG---LRGVLHLHDDSYGIEPLE-- --------------SDPDQHLLYRLQDVTS--QPKGCGTAHGGG----PHSPAQD-------------------VLHTGL HKRV-------AMKRAVLHQTHYVELLLVVDNERVNPLKLMPDCC--A------RVCVCACASIIYIQLNVRVVLVGLEI WTHQNLISTEG--AAGEVLSRFTQWREKALVPRQR-HDSAQLILK---KSF----GGTAGMAFVSTVCSRSHSGGINAFP NN-NLPAFASIVAHELGHNLGMNHDDGRSCTCP------SPACIMNSGTTY-----GRGDSRNFSS-CSADDFEKMIL-- LTGGSCLLNVPHPDEAYSAP--YCG--NRLVDVGE--ECDCGSQKE---CEDDPCCEHQTCRLKPGAQCA-YGECCSGCQ RARAQYLAGGTVCRSSTDE-CDLPEYCNGSSSFCQSDVFVQNGQPCSSQ-----QAYCYNGKCQHHDGQCRDIFGSK--- -AKASPEICFRNVNSKGDRFGNCG--YQNYGYKKCESRRNALCGKLQCSNIQTS-IVF-----SIQPSIISTFIDGAN-- --------CYGVDFQLGSD---------VPDPGMVNAGTKCGDERVCINFECVSAQVL-----------------S--YD CDVEKKCHGR--------------------------------GVCNSNRNCHCG-DGWRR-PSASSR------------- ---------------------------DKDTSLRDGLL---------------VFFFLVLPLLALGTFLYLRRNDLV--- -----RRL------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_ADAM9_a -------------------------------------------------------------------------------- -----------------QQTEHLSSYQLTVP-RPMGG---------RLRRDTAGRLPNQ--VSYSISVDGNDHIVHLERN E-WLLPADFTVFSYSQNGSLITS-----RPPVQDHCHYLGSVQDMEGSAVAMSICNG---LRSLIHLPTNSLVCFPPA-- --------------DSQQTEHLSSYQLTVP--RPMGGRLRRDTAGRLPNQPPGVR-------------------LVLQ-- ------------MKRAVLHQTHYVELLLVVDNDRYNYLNKNETAVRDE------MVHLANFVDSIYKQLNVRVVLVGLEI WTQQNQISTDG--GAGEVLSRFTQWREKELVPRRR-HDSAQLILK---KSF----GATAGMAFVSTVCSRSHGGGINV