>Homo_sapiens-SDC1(ENSP_254351) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRRAALWLWLCALALSL QPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPE------------------ -PTGLEATAASTSTLPAG---EGPKEGEAVVLPEVEPGLTAR--EQEATP--------------------RPRETTQLPT THLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPH--TEDGGPSATERAAEDGASSQLPAAE-GSGEQ- DFTFETSGENTAVVAVEPDR-----------------RNQSPVDQG---ATGASQGLLDRKE-----------------V LG--G-----------VIAG------------------GLVGLIFAVCLVGFMLYRMK---------------------- ------------------------------KKDEGSYSLEEPKQANGGAYQKPTKQEEFYA------------------- ----------------------- >Macaca_mulatta-SDC1(ENSMMUP_36726) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRRAALWLWLCALALSL QPAMPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTWLVRATPMSPE------------------ -PTGLEATAASTSTIQAG---EGPKEGEAVVLLEVEPDLTAR--EQEATP--------------------QPTETTQLPT THQAPTARATTAQEPATSHPHRDMQPGHHETSAPAGPGQADLHTPR--TEDGGPSATERAAEDGASSQLPAAE-GSGEQ- DFTFETSGENTAIVAVEPDH-----------------RNQSPVDPG---ATGASQGLLDRKE-----------------V LG--G-----------IIAG------------------GLVGLIFAVCLVGFMLYRMK---------------------- ------------------------------KKDEGSYSLEEPKQANGGAYQKPTKQEEFYA------------------- ----------------------- >Mus_musculus-SDC1(ENSMUSP_20911) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRRAALWLWLCALALRL QPALPQIVAVNVPPEDQDGSGDDSDNFSGSGTGALPD-TLSRQTPSTWKDVWLLTATPTAPE------------------ -PTSSNTETAFTSVLPAG---EKPEEGEPVLHVEAEPGFTARDKEKEVTT--------------------RPRETVQLPI TQRASTVRVTTAQAAVTSHPHGGMQPGLHETSAPTAPGQPDHQPPR--VEGGGTSVIKEVVEDGTANQLPAGE-GSGEQ- DFTFETSGENTAVAAVEPGL-----------------RNQPPVDEG---ATGASQSLLDRKE-----------------V LG--G-----------VIAG------------------GLVGLIFAVCLVAFMLYRMK---------------------- ------------------------------KKDEGSYSLEEPKQANGGAYQKPTKQEEFYA------------------- ----------------------- >Canis_familiaris-SDC1(ENSCAFP_5712) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRRAALWLWLCALALRL QPALPQIVATNVPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDMALLTAMPTAQE------------------ -PTGADDIDSSTSILLTR---EGPEGGEAVLVAEAEPGFTDR--EKETAH--------------------PPSETTPHPT THRASTARATTAQGPATLHPHRDAQPDHHQISVLAEPSQLDPHTPR--VEDGGPSATERAAEDGVSTQLPAGE-GSGEQ- DFTFDVSGENTAGTAVEPDQ-----------------RNQPPVDRG---ATGASQGLLDRKE-----------------V LG--G-----------VIAG------------------GLVGLIFAVCLVGFMLYRMK---------------------- ------------------------------KKDEGSYSLEEPKQANGGAYQKPSKQEEFYA------------------- ----------------------- >Ornithorhynchus_anatinus-SDC1(ENSOANP... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------HGSAVIWIWNSVIKG-P IPINQQIAATSLPPEDLDGSGDDDDNFSGSGNGPMPGVSVIDLSLPTRTNTLLTSVSAASTTY----------------- -PPIHREESNTEATLTSP---STEKDNEKLLVLSDHMHESSYPNEGATTG--------------------PVKGTTGQPT TRRPSTIKVTTVRLTSTVH-NADLPNSRRQNASRIFPGVFDSTLER-GSEGAVTASVSPEKASEMLTPFAETE-GSGDIS DFHFVGPSE-PPDIEVKHDP-----------------GKETPVDKG---ATGAAQGILDRKE-----------------V LGA-G-----------VIAG------------------GLVGLLFAMFLVGFMLYRMK---------------------- ------------------------------KKDEGSYSLDEPKQANGG-YQKPQKQEEFYA------------------- ----------------------- >Gallus_gallus-SDC1(ENSGALP_26538) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------LKTGQGWKWMVIALLTCIF PFSLKQTTNLNLPPEDLDSSGDDDDGFSGSGAGPLPDQSLTWRMPAEPTNSSLLATAVVFNEQLF--------------- -PRIESRTEKKVTTPPAT---SRVVTEEPVVAVKDETPLLGSPDEKPTDD--------------------AVVTTARSPT THFPSVLHVVPSEASGTVH---ELEPKTPGSEMPDTKGVPETNSTT-HPEGDIAAAPTTAPGDVAPTHEEVSEDGSGDPG DFILVKDED------LVPTQ-----------------NSEVPADSGRNAKAAGASGIMDRKE-----------------V LG--G-----------VIAG------------------GLVGLVFAVFLVAFMLYRMK---------------------- ------------------------------KKDEGSYSLDEPKQSNGG-YQKPHKQEEFYA------------------- ----------------------- >Anolis_carolinensis-SDC1(ENSACAP_10280) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MVLRRARILGAVLLCFQA AAVLSQLADTSLPPEDQDSSGDDDDAFSGSGAVPSEYPVVTWNVPLQESSNVSLVPPASTDSGDHQP---EVQRTDNPTE DYTTAPVSTISMAVFPVIDHVPDKLKEAVEDGGLHPPSEHVMTTPTVTTT--------------------SIPVSHHIST VRISTTQTPTTGKIPEPEIYHDVRHIPFPDKNIPASDTVPPSERSLYTTSLPTTSSTVQKDISSPPEEIVRSDDGSGDVG DFVFPQLDENPVIEEEP------------------ALTNRGMDIPKDEKSEAAAQGILDRKE-----------------V LGG-------------VIAG------------------GLVGLLFAGFLVG----------------------------- -------------------------------------------------------------------------------- ----------------------- >Takifugu_rubripes-SDC1(ENSTRUP_30181) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------LWRIWVLTL-------FPSVA------TKVSARSPSLTTDDL--------------------YLEGR----T SGNFPVDDEDGEDDGSG-SGSGDYDQAGP----NAATHSKLLGNRT-SPSSP----PPAETTRFSTDVIVPKETDGDNSL DRWQLPTPKDDGDQHNNG--------------------RGSRIYDSQRPEEVTSENLWERTE-----------------V LAA-------------VIAC------------------GVVGFLCAVFLLLLLAYRMK---------------------- ------------------------------KKDEGSYDLGDTKL-SNAQYHKAP-TKEFYA------------------- ----------------------- >Tetraodon_nigroviridis-SDC1(ENSTNIP_1... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MQQMLASLT-------ISGLS------TCVSAQTSVFGADDL--------------------YLEGR----S SGNFPLDDEDGEDDGSG-SGSGDYDDNISRTTISSETIPKLQQTTS-SPDNA----PATVTVSQHLTTTAKNTVPERKDS EEFNVLVDAEQEPEH----------------------------FSLRPIKGVTSENLWERTE-----------------V LAA-------------VIAC------------------GVVGFLCAVSLLLFLAYRMK---------------------- ------------------------------KKDEGSYDLGDNKL-SNAQYHKAP-TKEFYA------------------- ----------------------- >Tetraodon_nigroviridis-SDC1(ENSTNIP_767) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MKNLRLLFV-------VGLAA------GFIAATTSVFGADDL--------------------YLEGR----S SGNFPLDDEDGEDDGSG-SGSGDYGEK------TSVCFLTICCHRT-SPSSA----PPFESTSLSTGI---KEANEDNSL DRWERPTPTDIEDQH--------------------------EIIEKG----VTSENLWERTE-----------------V LAA-------------VIAC------------------GVVGFLCAVSLLLFLAYRMK---------------------- ------------------------------KKDEGSYDLGDNKL-SNAQYHKAP-TKEFYA------------------- ----------------------- >Gasterosteus_aculeatus-SDC1(ENSGACP_9... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MRNLRLLVL-------FGLASGFISEKVFVSSQTTFPVIDDL--------------------YLEGQ----T SGELSIDDEDGEDDDDGGSGSGDYGKEIT-ELFCNCVFLYFNLGPT-ANNVL----EHLTTVSWELVPSRPQPSAAAPLS PSTKAPVSQNPATKSTS----------------------SATIPPVDTPEEVTSENTWERTD-----------------V LAA-------------VIAC------------------GVVGFLCAVFLLLLLAYRMK---------------------- ------------------------------KKDEGSYELGDTKV-STTAYQKAP-TKEFYA------------------- ----------------------- >Homo_sapiens-SDC2(ENSP_307046) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MRRAWILLT-------LGLVACVSAESRAELTSD-----KDM--------------------YLDNSSIEEA SGVYPIDD----DDYASASGSG--ADEDVESPELTTSRPLPKILLT--SAA-----PKVETTTLNIQ--NKIPAQTKSPE ETDKEKVHLSDSERKMD---------------------PAE--EDTNVYTEKHSDSLFKRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SSAAYQKAP-TKEFYA------------------- ----------------------- >Macaca_mulatta-SDC2(ENSMMUP_1293) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MRRAWILLT-------LGLVACVSAESRAELTSD-----KDM--------------------YLDNSSIEEA SGVYPIDD----DDYASASGSG--ADEDVESPELTTSRPLPKIPFT--SAA-----PNVETTTLNIQ--NKIPAQTKSPE ETDKEKVHLSDSERKMD---------------------PSE--EDTNVYTEKHSDSLFKRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SSAAYQKAP-TKEFYA------------------- ----------------------- >Mus_musculus-SDC2(ENSMUSP_22871) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MQRAWILLT-------LGLMACVSAETRTELTSD-----KDM--------------------YLDNSSIEEA SGVYPIDD----DDYSSASGSG--ADEDIESPVLTTSQLIPRIPLT--SAAS----PKVETMTLKTQ--SITPAQTESPE ETDKEEVDISEAEEKLG---------------------PAI--KSTDVYTEKHSDNLFKRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SSAAYQKAP-TKEFYA------------------- ----------------------- >Canis_familiaris-SDC2(ENSCAFP_13931) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------TRGRWTVAT-------HGLGRHLWMSHRAELTSD-----KDM--------------------YLDNSSVEEA SGVYPIDD----DDYASASGSG--ADEDGESPEPTASRPLPNAGPT--SAV-----PAAEATTLKTR--GKEPAQTESPE EIGEDKVRLSDSERKVD---------------------PSD--EDANVYTEKHSDNLFKRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SSAAYQKAP-TKEFYA------------------- ----------------------- >Monodelphis_domestica-SDC2(ENSMODP_8527) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------L GAAGPLGIMQRVWILLT-------FGLVACVSGESRAELTSD-----KDM--------------------YLDNSSIEEA SGVYPIDD----DDYASASGSGKTEEEVVESPQMPTARTIPKIPFT--SDA-----PKVETTTLKIQ--TKIPAQTKSPE EIDKEKVRISDSGTKIE---------------------TPD--EDTNVYTEKHSDNLFKRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SSAAYQKAP-TKEFYA------------------- ----------------------- >Ornithorhynchus_anatinus-SDC2(ENSOANP... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------KAEVTSD-----KDM--------------------YLDNSSIEEA SGVYPIDD----DDYASASGSG--ADEDGESPQMTTSHTLPKIPST--PVS-----PKVETTTLKIQ--TKIPTQTESPE EIDKENIQDSESDKKME---------------------SAD--DDKNVHTEKHSDNLFKRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SSAAYQKAP-TKEFYA------------------- ----------------------- >Gallus_gallus-SDC2(ENSGALP_30197) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------LLWLWLKVK-------WGKVACS-IVTRADLTSD-----KDL--------------------YLDNSSVEEA SGVYPIDD----DDYSSGSGSG--AEEDEDSTVTTTSRIVPKLPTT---SDA----SRAETTTVKMQ--TKMPAQTKSPE EIDKE--ERPEVDSKKK---------------------SNEPGDDTDVFTEKHSENLFQRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SSAAYQKAP-TKEFYA------------------- ----------------------- >Anolis_carolinensis-SDC2(ENSACAP_4211) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MRNVRILLA-------FAGVACVSGETRAALTSD-----KDL--------------------YLDNSSIEEA SGVYPIDD----DDYTSGSGSD--EEEDENTMIEPTPRMLPERPVI-PVSDS----PRTERTTQKTQ--TKVPTQTKSSE ELDQKKILKPEAENKND---------------------KSEPSEDTDVFTQKHSENLFQRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SSAAYQKAP-TKEFYA------------------- ----------------------- >Danio_rerio-SDC2(ENSDARP_26190) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MRNLWMILT-------LGLTAFLSGERISVSAAKSPSTTDDL--------------------YLEEA---GS GG-YPEDD----DDFSSGSGSGAGEV-IEDPVTVNTLFFVPK-AEP-TQDSTKDFTPKVETVTSQDAPKDSKKRRIEVAV PVTEDSRRNPVTSTTSI---------------------PRP----PMDPQDVQSENLFQRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SGAAYQKAP-TKEFYA------------------- ----------------------- >Takifugu_rubripes-SDC2(ENSTRUP_9720) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------DL--------------------YLDDT---GS GGYYPEDD----DDFNSGSGSGGGEEVVEEAVTISTVYIKPNAVEP-TQDSTKVFTPRVEAATDRET---AQEITPRKPV RTESAHLSVLMQAPVPA---------------------TED----TQKAIEVRTENLFQRTE-----------------V LAASA-----------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-TGAAYQKAP-TKEFYA------------------- ----------------------- >Tetraodon_nigroviridis-SDC2(ENSTNIP_2... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------DL--------------------YLDDT---GS GGYYPEDD----DDFNSGSGSGGGEE-AEEAVTISTVYIKSNAAEP-TQDSTKVFTPRVETATHRDR---ARESMPRKPI RTELKEVRS-ARASHQG---------------------KTW----TDIDTEVHTENLFQRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SGAAYQKAP-TKEFYA------------------- ----------------------- >Gasterosteus_aculeatus-SDC2(ENSGACP_3... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MRSVWIILT-------LGLAAFLSGERI-ADAAKTSSQADDL--------------------YLDDA---GS GGYYPEDD----DDFNSGSGSGGGAK-DED-QTVSVVYIEPKAAEP-TQDATKDFTPKVETPTVREP---RKPVRTEAPA PVTEDAQRNQMTSTTSA---------------------PGA----PQDAIEVRTENLFQRTE-----------------V LAA-------------VIAG------------------GVIGFLFAIFLILLLVYRMR---------------------- ------------------------------KKDEGSYDLGERKP-SGAAYQKAP-TKEFYA------------------- ----------------------- >Homo_sapiens-SDC3(ENSP_344468) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MKPGPPHRAGAAHGAGAGAGAAAGPGARGLLLPPLLLLLLAGRAAGAQRWRSE N-FERPVDLEGSGDDDSFPDD---ELDDLYSGSGSGYFEQESGIETA-MRFSPDVALAVS----TTPAVLPTTNIQPVGT PFEELPSERPTLEPATSPLVVTEVPE---EPSQRATTVSTTMATTAATSTGDPTVATVPATVATAT---PSTPAAPPFTA TTAVIRTTGVRRLLPLP-----LTTVATARATTPEAPSPPTTAAVLDTEA--------------------PTPRLVSTAT SRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTPETFLT-TIRD-EPEVPVSGGPSGDFELP-EEETTQPDTA NEVVAVGGAAAKASSPP-----GTLPKG--ARPGPGLLDNAIDS-GSSAAQLPQKSILERKE-----------------V LVA-------------VIVG------------------GVVGALFAAFLVTLLIYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ASVTYQKPDKQEEFYA------------------- ----------------------- >Macaca_mulatta-SDC3(ENSMMUP_17778) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------AGAAHGAGAGTGAAAGPGARGLLLPPLLLLLLAGRAAGAQRWRSE N-FERPVDLEGSGDDDSFPDD---ELDDLYSGSGSGYFEQESGIETA-MRFSPDVALAVS----TTPAVLPTTNIQPVGT PFEELPSERPTPEPATSPLVVTEVPE---EPSQRATTISTTTATTAATTTGAPTVATVPATVTRR----PSTPAAPPFTA TTAVVRTTGVRRLLPLP-----LTTVATARATTPEAPSPPTTAAVLDTEA--------------------PTPRLVSTAT SRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTPETFLT-TIRD-EPEVPVSGGPSGDFELP-EEETTQPDTA NEVVAVGGAAAKPSSPP-----GTLPKG--ARPGPGLLDNAIDS-GSSAAQLPQKSILERKE-----------------V LVA-------------VIVG------------------GVVGALFAAFLVTLLIYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ASVTYQKPDKQEEFYA------------------- ----------------------- >Mus_musculus-SDC3(ENSMUSP_65877) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MKPGPP-RRGTAQGQRVDT-ATHAPGARGLLLPPLLLLLLAGRAAGAQRWRNE N-FERPVDLEGSGDDDSFPDD---ELDDLYSGSGSGYFEQESGLETA-MRFIPDMALAAP----TAPAMLPTTVIQPVDT PFEELLSEHPSPEPVTSPPLVTEVTEVVEESSQKATTISTTTSTTAATTTGAPTMATAPATAATTA---PSTPEAPPATA TVADVRTTGIQGMLPLP-----LTTAATAKITTPAAPSPPTTVATLDTEA--------------------PTPRLVNTAT SRPRALPRPVTTQEPDVAERSTLPLGTTAPGPTEMAQTPTPESLLT-TIQD-EPEVPVSGGPSGDFEL--QEETTQPDTA NEVVAVEGAAAKPSPPL-----GTLPKG--ARPGPGLHDNAIDS-GSSAAQLPQKSILERKE-----------------V LVA-------------VIVG------------------GVVGALFAAFLVTLLIYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ASVTYQKPDKQEEFYA------------------- ----------------------- >Canis_familiaris-SDC3(ENSCAFP_16522) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------AQRWRNE N-FERPVDLEGSGDDDSFPDD---ELDDLYSGSGSGYFEQESGIETA-MRFSPDVAMAVS----TTAAVLPTVDIQPVGT PFEELPSEHPTPEPATSPPVVTEVPE---EPSQRATTISTPTAPTAATTAGALTVATVPATVATAV---PSIPAAPPSTA TTSVIRTTGVRRLLPLP-----LTTAATARATTPAAPSPPTTVAVLDTEA--------------------PTPRMVSTAT SRPRALPRPATTQEPDLPEKSTLPLGTTAPGPTEVAQTPTLESVLT-TIRD-EPEVPVSGGPSGDFELP-EEETTQPDTA NEVVAVGGAAAKPSPPP-----GTLPKG--ARPGPGLLDNAIDS-GSSAAQLPQKSILERKE-----------------V LVA-------------VIVG------------------GVVGALFAAFLVTLLIYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ASVTYQKPDKQEEFYA------------------- ----------------------- >Monodelphis_domestica-SDC3(ENSMODP_21... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------RGMLLPPLLLLLLAGRAAGAQRWRSE N-FERPVDLEGSGDDDSFPDD---ELDDHYSGSGSGYFEQESGIEKA-VRMSTNVAVALS----TTPAVLPTSAVQPMGT PFEMQPSESPSPKSATTVSAVTKVSAVPTVAASRAVEAMATEAPAVATEAPAVTTTTTAAATADIIPTAASIPTFPPSAV SGPVPRTTVLPKLPPPPPATVAATVGATVQATAPATFTLSTAASGLDTEV--------------------STPKPVVTST --PSTLPKPETSRPPAVLEKSTVAVGS-------EALTPTPEAPLA-TQRDVEAEVPF---PSGDSEPP-EEGITQPELD NEVVAVG----DRTTVA-----GVMPKD--EKGGPDLFDNTIDL-GNSAAQLPQKNILERKE-----------------V LVA-------------VIVG------------------GVVGALFAAFLVTLLIYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ASVTYQKPDKQEEFYA------------------- ----------------------- >Gallus_gallus-SDC3(ENSGALP_792) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MPAELRGLAVLLLLLSARAALAQRWRNE N-YERPVDLEGSGDDDPFGDD---ELDDIYSGSGSGYFEQESGLETA-VSLTTDTSVPLP----TTVAVLPVTLVQPMAT PFELFPTEDTSPEQTTSVLYIPKITEAPVIPSWKTTTASTTASDSPSTTSTTTTTAATTTTTTTTI------------ST TVATSKPTTTQRFLPPF-----VTKAATTRATTLETPTTSIPETSVLTEV--------------------TTSRLVPSST AKPRSLPKPSTSRTAEPTEKS-TALPSSPTTLPPTEAPQVEPGELT-TVLDSDLEVPTSSGPSGDFEIQEEEETTRPELG NEVVAVV-----TPPAA-----PGLGKN--AEPG--LIDNTIES-GSSAAQLPQKNILERKE-----------------V LIA-------------VIVG------------------GVVGALFAAFLVMLLIYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ANVTYQKPDKQEEFYA------------------- ----------------------- >Xenopus_tropicalis-SDC3(ENSXETP_15457) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------AERWRSE FEDERPVDLESSGDDDLFEDE---DMDDVYSGSGSGNFELESGLDLG-FRFTTKTPISPP----------TVTALKPAPT DDFLPPVQSTWVPPTTQASVVHRHNP--WVPPEAPDTPSLPAAPTPTIPSKQAATTEATAT------------------- --ETVRTTEVRRLQPVV-------VVSTEIMATPSS-TDKDMFTWEATDE--------------------QEVTSFNTES GRVWPTEDWRTSVEDIKVEETEKVSPTLQP------QTESWEVTAV-TSRDSDFEIPISGGPSGDFEIQ-EEDVVPQTEP PTLPDLGNEVLLPATAP-----PDLARG--RKPDTGLIDNTIDS-GNTLAQMPQKNILERRE-----------------V LIA-------------VIVG------------------GVVGALFAAFLVMLLIYRMK---------------------- ------------------------------KKDEGSYALEEPKP-ASVSYQKPETHEEFYA------------------- ----------------------- >Anolis_carolinensis-SDC3(ENSACAP_838) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------AQNWRNE N-FERPIDLEASGDDDSFEDEEMEETEDLYSGSGSGYFEQDSGIKAV-LPVTTEVPIVLTT---TTAAVLPVTSVQPVGI PFVPFPTEEATAGPTTGDPLTPRMSEALAVTVQKASGAPTMAPTTP---------------------------------- --ASTKPTTVSRVLVPF-----ITVLATTQPVTLETPTAVVVTK---TEA--------------------TTSLPVTTSV TKVRLMPTLSTSQEPEVSEESTTPLPPLSPTASTESTDPLDVGLST-AITSRDPEPPVS----GDFEIREEEDVAPTELS NEVAPLV-----TPAAG-----PVLRKN--VETG--LIDNTIES-GNSAAQLPQKNILERKE-----------------V LIA-------------VIVG------------------GVVGALFAAFLVMLLIYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ASVTYQKPDKQEEFYA------------------- ----------------------- >Danio_rerio-SDC3(ENSDARP_109084) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MKLPCWITLLLLQTALA QRSKSQPSDDESSGDEPYDDE------DFYSGSGSGYPDIKVRPSSVGVVFTTEEPLPLSTTQATGPAPSASPAAEPSSP PPPEVERESGLGQDVDSKLEIEKKYEEYDEEEEIRPTRKEQEPDTEKVQEREQDRSKAT--------------------- --VAPRLTDVPIVFLGS----STVGGATETTTDLEDLGGREEETDEDLYI--------------------TKETIVLDPS SETDMITDEITTTEFIPTTIPSTTAKPTRPRPILTTPSPTAVRPRQ-PQTTPSRAAPTESSTRSVMTTT-QTQVPDETVN NEVAGPGPSGDFEIRENEVRQNNDLGRGRAVPGEPDLTGNTVDAAGSSAAQLPQKNILERKE-----------------V LIA-------------VIVG------------------GVVGALFAAFLVMLLVYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ATVTYQKPDKQEEFYA------------------- ----------------------- >Takifugu_rubripes-SDC3(ENSTRUP_33343) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --THTARKTGNGQGED------------------QPLRRICVLEAAACTGKNKKHVKHT--------------------- --TSCKQVSIPADLICS----NQITAAQGSRD------------------------------------------------ ----------NRHQGSADREDDPCADA-------------RVHTGE-FGALVCVFDFKRSGSRLTFLPA-FQEA-----N NDVGAAGPSGDFEIRDD---RRNDLGHG-VAPGEPDLTSNTVEG-GSSAAQLPQKNILERKE-----------------V LIA-------------VLIGGLLAVVFADFLVIAVIVGGVVGALFAAFLVMLLVYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ATVTYQKPDKQEEFYA------------------- ----------------------- >Tetraodon_nigroviridis-SDC3(ENSTNIP_204) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------IDDEGSTREDFYDDE------DLYSGSGSG-CLILLNMTAAGFLAANRSPFPQILLAVIRLRKTDVHFAPASAS EFIPQASEAGLLESTRTAAS--------PAPPAPPAPPAPPAPPPVFVSAIGSSRSRAR--------------------- --VNTEKIKARTLEPPA----RIRTGSRENRRGAFSGWEGREEREGGRQV--------------------RTFAVWPIGR HRTSRVKEELSRLERIRAAARTTAAPP----------SPTAVALAT-SEPALGTGESAAPPGGAEDLLN-NQEEEDVYLS TEATTFPGFGMETTRGED--ARNELGRG-VSPVDPDLMGNTVEG-GSSAAQLPQKNILERKE-----------------V LIA-------------VIVG------------------GVVGALFAAFLVMLLVYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ATVTYQKPDKQEEFYA------------------- ----------------------- >Gasterosteus_aculeatus-SDC3(ENSGACP_7... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------METTTEEDMSATTET--------------------- --TPEPTTTAPS-----------TTAATVKTR------------------------------------------------ ----------WPFR---PRVPTTTATP-------------AVKT-------------ERT-TRPQQPTV-TQEG-----N NEAGAAEPSGDFEVRDD---RRNDLGRG-GRPADPDLTGNTVDG-GSSAAQLPQKNILERKE-----------------V LIA-------------VIVG------------------GVVGALFAAFLVMLLVYRMK---------------------- ------------------------------KKDEGSYTLEEPKQ-ATVTYQKPDKQEEFYA------------------- ----------------------- >Homo_sapiens-SDC4(ENSP_361818) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MAPARLFA-LLLFF-------VGG-------VAESIRETEVIDPQDL--------------------LEGRYF---- SGALPDDEDVVGPGQE----SDDFE----------LSGSGDLDDLE-DSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEP KKLEENEVIPKRISPVEE--------------------SEDVSNKVSMSSTVQGSNIFERTE-----------------V LAA-------------LIVG------------------GIVGILFAVFLILLLMYRMK---------------------- ------------------------------KKDEGSYDLGKK-----PIYKKAP-TNEFYA------------------- ----------------------- >Macaca_mulatta-SDC4(ENSMMUP_4542) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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