>Homo_sapiens-KCNS1(ENSP_307694) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGP--DTGIRWRRSDEALRVNVGGVRRQL SARALARFPGTR-LGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWG LGENALAACCRARYLERRLTQPH---AWDEDSDT-----PSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLA PSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQG---GKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FNTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSNH--QEFEDLLSSIDG---VSE--ASLETSRET--------------- ------------------SQEGQSADLESQAPSEPPHPQMY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Macaca_mulatta-KCNS1(ENSMMUP_17362) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MLMLLVRGTHYESLRSKVVLPTPLGGRGTEALVSECPSP--DTGIRWRQSDEALRVNVGGVRRLL SARALARFPGTR-LGRLQAAASEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWG LGENALAACCRARYLERRLTQPC---AWDEDSDT-----PSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLA PSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGTGGKELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FNTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSNH--QEFEDLLSSVDG---VSE--ASLETSRET--------------- ------------------SQEGRSADLETQAPSEPPHPQMY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Mus_musculus-KCNS1(ENSMUSP_38901) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVSEFPGP--GSRVPWRPRDEALRVNVGGVRRLL SARALARFPGTR-LGRLQAAASEEQARRLCDDYDAAAHEFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWG LGENALATCCRARYLERRVARPR---AWDEDSDA-----PSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEEVRDDPVLRRLEYFCIAWFSFEVSSRLLLA PSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDQRGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAE-EENEG-FHTIPACWWWGTVSMTTVGYGDVVPET-VGGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRSSGQ--REFEDLLSSVDG---VSD--VSLETSRDT--------------- ------------------SQEGRSTDLETQAPREPAKSHSY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Rattus_norvegicus-KCNS1(ENSRNOP_18364) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVSEFPGP--GSRVPWRPRDEALRVNVGGVRRLL SARALARFPGTR-LGRLQAAVSEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWG LGENALATCCRARYLERRVTRPR---AWDEDSDA-----PSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEDVRDDPVLRRLEYFCIAWFSFEVSSRLLLA PSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDRRGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAE-EKNVG-FDTIPACWWWGTVSMTTVGYGDVVPET-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRSSGQ--REFEDLLSSVDG---VSD--VSLETSRET--------------- ------------------SQEGRSTDLETQAPSEPAKSHSY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Oryctolagus_cuniculus-KCNS1(ENSOCUP_2... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VQRELRAT-RARCA-LRRR--SDMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYRAEDARD---------------DDPVLRRLEYFCIAWFSFEVSSRLLLA PSTRNFFCHPLNLIDIVSVLPFYLTLLVG------------------KVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSDH--REFEDLLSSMDG---ASE--ASLETSRET--------------- ------------------SQEGQSADLETQAPSEPPDSRGC--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Bos_taurus-KCNS1(ENSBTAP_11681) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVSESPGP--SARVPWRRSDEALRVNVGGVRRRL SARALARFPGTR-LGRLQAAASEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWG LGESALATCCRARYLERRVTRPR---AWDEDSDT-----PSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLA PSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALRDRGGAGGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSDH--REFEDLLSSIDG---VSE--ASLETSRET--------------- ------------------SQEGRSEDLEAQASSGPPNSQVY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Canis_familiaris-KCNS1(ENSCAFP_14170) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------ERVISLSTPTPLGGFGPQAMVSESPEP--GARAPWRRSGEALRVNVGGVRRRL SARALARFPGTR-LGRLQAAGSEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGRLHVLDELCVFAFGQEADYWG LGEGALAACCRARYLERRVARPR---DWDEDSDT-----PSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQPREAAAAVAAVAAGRGAEGVRDDPVLRHLEYFCIAWFSFEVSSRLLLA PSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDRGGAGGEDLGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSDP--REFEDLLSSVDG---VSE--VSLETSRET--------------- ------------------SQEGRSIDLEAQAPSGPPDSQVY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Loxodonta_africana-KCNS1(ENSLAFP_2972) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------GP--RAAVSWRRRDEVLRVNVGGVRRRL SASSVARFPGTR-LGRLQAATSEEQARRLCDDYDAVAREFYFDRHPGFFLVLLHFYRTGRLHLLDELCVFAFNQEADYWG LNEGALAACCRARYLERCVAGPH---AWDEDSDT-----PSSVDPCPDEISDVQRQLARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAHEAAAAVAAVAAGRSAEEANDDPVLRRLEYFCIAWFSFEVSSRLLLA PSARNFFCHPLNLIDIVSVLPFYLTLVAGAALGNRGGAGGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VTGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSDP--REFEDPLSSVDG---VSE--ASLEMSHET--------------- ------------------SQEGSSADLEAQHPREPPNSKAY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Equus_caballus-KCNS1(ENSECAP_8300) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------LMLLDQATHFENYWSIVILPTTLGSRRAAAMVSESPGP--GAGVPWRRSDEALRVNVGGVRRRL SARALERFPGTR-LDSLHAAATHLHARRQRSAYEATA-KFYFDRHPGFFLGLLHFYRTGRLHVLDELCVFAFGQEADYWG LGESALAACCRARYLERRVARPR---AWDEDSDT-----PSSVDPCP-EISDVQRELARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLA PSTRNFFCHPLNLIDIVSVLPFYFTLVAGAALGNQGSASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSCVAYTAEKEEEVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSGH--REFEDLLSSVDG---VSE--ASLETSHET--------------- ------------------SRGGRSADLQAQAPSGPPKSQIY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Myotis_lucifugus-KCNS1(ENSMLUP_10759) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------QSATTMVSESPGP--GATVLWRRSDEALSVNVGGVRRRL SARALARFPGTR-LGRLQAAASDEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHGL-ELCSFPFRPGAEYWG LGESALATCCRARYQERRVARPR---AWDQDSDA-----PSSVDPNPGEISDVQRELARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRIAKDVRDDPVLRRLEYFCIA-FSFEVSSRLLLA PSPRNFFCHPLNLIDIVSVLPFYLTLMAGAALGDQGGAGGEDLGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSGH--QEFEDLLSSVDG---VSE--GSLETSRET--------------- ------------------SQEGRSADLGTQAPSEPPNSKIY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Pteropus_vampyrus-KCNS1(ENSPVAP_11945) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MLTLPVQGTHFENYWSILMLPKTLGGRRAAAMVSESPRP--GARVPWRRRDEALRVNVGGVRRRL SARALARFPGTR-LGRLQAAASEEQARRLCDDYDPAAREFYFDRHPGFFLGLLHFYRTGRLHVLDELCVFAFGQEADYWG LGESALATCCRARYLERRVARPR---AWDEDSDT-----PSSVDPCPGEISDVQRELARYGAARCGRLRRRLWLTMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAALAAVAAGRSAEDVRDDPVLRRLEYFCIAWFSFEVSSRLLLA PSTRNFFCHPLNLIDIVSVLPFYLTLMAGAALGDQGGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSGH--QEFEDLLSSVDG---VSE--GSLETSRDT--------------- ------------------SQEGRSADLEAQDPSRPPNSHIY--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Monodelphis_domestica-KCNS1(ENSMODP_2... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------AARRSGP-TMVSESPSGRWRPGLPG----EALNVNVGGVRRRL SPRALAQFPDTR-LGRLQAAASEEQARQLCDDYDPNKREFYFDRHPGFFLCLLHFYRTGRLHVLEELCVFAFGQEAEYWG LGDCFLAACCSGRYHERRLERHRR--SWDEESD------VSSVDTSPDEISDFNQDLQRYRAVRCGQLRKRLWLTMENPG YSLPSKLFSCVSIGVVLVSIAAMCIHSMPDHQDQD-EDVTEPP------------TVLQCLEYFCIAWFSFEVASRLLLA PSLPRFFRHPLNLIDIVSVLPFYLTLLVSTMLGRSS-----NLGSLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEREEGDG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSDQ--REPS---LSVDASS-TED--GASQASNET--------------- ------------------SREENFPE---------PKSQ----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Ornithorhynchus_anatinus-KCNS1(ENSOAN... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------GGPGAMVSESAGVGWVPGVPGVPGEEAINVNVGGVRRRL SSRAVSRFPETR-LGRLLRAGSEEQALQLCDDYDPGAREFYFDRHPGFFLGLLHFYRTGRLHVLEELCVFSFGQEAEYWG LGEGLLASCCSGRYHERRLERRRR--GWDEDSE------VSSVDTSPDEISDFNRDLLRYRTVRCGRLRRRLWLTMENPG YSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQARDGEAPAGPPPAPPAPV---DDPLLRRLEYFCIAWFSFEVSSRLLLA PSLRRFFRHPLNLIDIVSVLPFYLTLLVDVALGGDS-----ELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSDK--KGSGGSGGSGRSSS-LQE--VTSEASSQA--------------- ------------------SRRGSSPEREAWAPGRPPARQ----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Gallus_gallus-KCNS1(ENSGALP_6470) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------EEDLININVGGLRRRL SPSALSKFPDTR-LGRLLSCDSEESILQLCDDYDVSAREFYFDRNPGFFLYVLHFYQTGKLHVMDELCVFSFCQEIEYWG INEFFLDSCCSYRYHERKLEGRHH--TWDEESE------VSSVDTSPDEISDINHELLRYSRLRCGTARKRLWLTMENPG YSIPSKLFSFVSISVVLVSIATMCIHSMPEYQRVDESGAVL------------DEPVLHKLEYFCISWFTFEVSSRLLLS PNPKKFFKHPLNLIDIVSVLPFYFTLLVDVTAGSDS-----ELGNLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----KQKALEAAVRNSEK--KKPE----EME-----SE--QDSEVLSES--------------- ------------------SL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Anolis_carolinensis-KCNS1(ENSACAP_12013) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ININVGGLRRRL SSSALSKFPDTR-LGRLLFCDSEESILQLCDDYDVGAREFYFDRNPGFFLYVLHFYQTGKLHVMEELCVFSFCQEIEYWG INEFFLDSCCSYRYHERKLESGHH--NWDEESE------VSSVDTSPDEILDFNHDLLHYSTLRCGNLRKRLWLTMENPG YSIPSKLFSFVSISVVVASIATMCIHSMPEYQQPDEEDNMK------------DDSVLQNVEYFCISWFTFEVTARLLLA PNRRKFFRHPLNLIDIVSVLPFYFTLLVDVTLGSDS-----ELGNLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKH SYREVGILLLYLAVGVSVFSGVAYTAEKEEHVG-FDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGILVV ALPITIIFNKFSHFYR----RQKALEAAVRNSGK--KEPE----DSEN---YPS--QESEILSEV--------------- ------------------YQRDDDLTRN---------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Danio_rerio-KCNS1(ENSDARP_23216) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVYGQFLH------RRGPEESFINLNVGGFKQQV ERVVLQRFPHTR-LARLLYCSSEAAILQLCDDYAAADREYYFDRNPCFFRYVLNFYHTGKIHLMEELCVFSFSQELEYWG IKELHLDTCCSNRFQEQKENMGDP--DWGNEDDPQNQLQDSLDSSM-EELSAFDKDLEKFEGTWCAEKRKELWLRLENPG YSRSAKILAVFSLSVVLISIIAMCIHSMPEFHQKDANEKEVE------------NPVLDVFETFCVLWFSLEFIVRLVVT PCLRKFICNALNMIDFASIVPFYATLAFEKVDPE----ESEELENVGRVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLILFLSVGISIFSVLIYFVEREDHESELQTIPVGWWWATISMTTVGYGDTYPVT-LPGKLIGTLCIICGLLVV ALPISIIFNKFSKYYQ----RQKALVESDQLQTEDEKQPDLSMPFLHIADLYS---QKMNSLAHS--------------- ------------------ASSR---SSEGDATDASSIADVEFVC--SAGQPKANNVT----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Danio_rerio-KCNS1(ENSDARP_28545) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVKEKN-----AWWILDPKDHLLHINVGGLRNTL CSSILKKFPDTR-LGQLLSCDSEDDILQLCDDFDVQRKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCIFSFSQEIEYWG ISDFFLDSCCSYRYLDRKLER-HH-KSWDEESD------VSSVDTSVDEISDLNKDIEHFHEMRFGNIRKCLWLTLENPG YSIPSKLFSLLSICVVLISIATMCINSIPEYQKFDENGNLIE------------DPTMHVLEVFCICWFTFEVVTRMLLA PNHRKFFLLPLNVIDIISVMPIYITIFFDMLIGSES-----ELGNLGKLVQVLRLMRIFRVLKLARHSTGLRSLGATLRH SYREVGILLLYLAVGVSVFSGMAYTAENEEDVG-LDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGTLVV ALPITIIFNKFSHFYR----KQKALEASVRNNNN--KKFVMRQQRNSGDSAIHG--HIHCLEDEE--------------- ------------------MDEDVDFDTGVVNFCYEDHPLTYTVRCVH--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Oryzias_latipes-KCNS1(ENSORLP_24891) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------PAGRGAFSRGGSQEPGGSAPKFRGSYLDIWILVQTLTRGKFWSVRVTDPEEDLVHVNVGGLRRSL CSSTLKRFPDTR-LGKLLACASEEDILQVCDDYDVQQKEFYFDRNPGLFPYVLHFYQTGKLHVMEELCVFSFSQEIEYWG INEFFLDSCCSYRYHDRKLESSRH-RSWDEDSE------VSSVDTCVDEISDLNRDMQHFRHVRYGNLKRCLWLTLENPG YSIPSKLFSLLSIGVVLTSIAAMCIHSLPEYQTFDADGKLME------------DPTLQALEVFCICWFSFEVGTRLLLA PNRRKFFRHPLNIIDLVSVVPIYITLVFDVTLGSES-----ELGNLGRLIQVFRLMRIFRVLKLARHSTGLRSLGATLRH SYREVGILLLYLAVGVSVFSGIAYTAECEEDVG-LDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGTLVV ALPITIIFNKFSHFYR----RQKALEASVRN------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Tetraodon_nigroviridis-KCNS1(ENSTNIP_... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------RVQGQL------WKRPGQEEALVHVNVGGLRRSL CCSTLEKFPDTR-LGRLLACRSQEDILQVCDDYDVQQREFYFDRHPGLFRHVLHFYQTGKLHVTEELCVFSFSQEIEYWG INEFFLDGCCSYRYHDRKLERARR-RSWDEESD------ASSLDTCVDEISDLNRDMQHFQDVSYGNVRRCLWLTLENPG YSIPSKLFSLLSISVVLTSIAITCINSIPEYQSLDPDGRPLE------------DATTRALEGFCSCWFTLEVVTRLLLA PNRKRFFHHPLNIIDMASVVPIYITLTFDLTVGSES-----ELGDLGRLVQVFRLMRIFRVLKLARHSTGLRSLGATLRH SYREVGILLLYLAVGVSVFSGFAYTAEYEEDVG-LDTIPACWWWGTVSMTTVGYGDVVPVT-VAGKLAASGCILGGTLVV ALPITIIFNKFSHFYR----RQKALEASECGSEE--P------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Gasterosteus_aculeatus-KCNS1(ENSGACP_25) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------DGLVHINVGGLKRSL CRSTLRRFPNTR-LGKLLSCDSEEDILQVCDDYDVQQKEFYFDRNPGLFTYVLHFYQTGKLHIMEELCVFSFSQEIEYWG INEFFLDSCCSYRYHDRKLEGSRH-HTWDEDSE------VSSVDTSVDEISDLNRDMLHFQEVRHGNVRKCLWLTLENPG YSLPSKLFSLVSIGVVLASIASMCISSIPEYQTFDDEGKLME------------DPSMQALEVFCTCWFTFEVVTRLLLA PNKRKFLHHPLNIIDLVSVAPVYVTLLFDTTVGSES-----QLGVLGRLVQVFRLMRIFRVLKLARHSTGLRSLGATLRY SYREVGILLLYLAVGVSVFSGIAYTAEYEEGVG-LDTIPACWWWG-VSMTTVGYGDVVPRHGGLGSWPAGGCILGGTLVV SLPITIIFNKFSHFYR----KQKALEASVRNNHR--RK------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Ciona_savignyi-KCNS1(ENSCSAVP_19029) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------LSLAFNQELSQLGNSPSVAP-----LSNKLSHRKRVRLNVGGYLHEV RWGTLEQLPHTR-LGKLRESETRSEIMVLADDHDESTNEYFFDRHPGAFTPILNFYRTGKLHMPEDICALAFSAELDYWG IDDIYIESCCQARYHQKKEQILE--------------------ELRREADAIRERQGDDFRGMCCADKRKIIWDLMEKPN SSLAAKVIAIVSVLFIVLSTVALTLNTVQGLRGKDG----FD------------NPQLAHIESVCIAWFTMEYLLRFMSS PNKWKFFKGPLNIIDLLAILPYYITLFLTKSN-MQILQ----FQNVRRIIQIFRIMRIMRILKLARHSTGLQSLGFTLRR SYNELGLLMLFLAIGIMMFSSLAYFAEKDDNPKQFSSIPASFWWATITMTTVGYGDISPTT-LLGKLVGGICCVTGVLVI ALPIPIIVNNFSEFYKEQKRQEKALKRREALETAKRTGSIVT---MNLRDVFAK----VGVTLDQ--------------- ---------------------FMSSRS----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Apis_mellifera-KCNS1(XP_393546.3) MPSEK-RFEDDSTLADGE------RNGSTVVTGPVLSSSSS--------------------------------------- --------------------CTVPYIGTDQGFVFEGG-------------------GTTTLQRAGATSISVASCTGSG-- --------GGILGG---------VGIGSNVVVGSGINMGGNVTLGGVAVVGGVKSGGG-GGGNKEVRYAPF-----SSSV GLTSSVAPVNLTPPPLPPPPPPPPLPPPPPPPPLPLQMQQQRAYSRSMTSLPP-EPFMIMRSKALNRRVSINVGGVKHEV LWRTLERLPHTR-LGRLKDCNTHEAITELCDDYSLIDNEYFFDRHPKSFSSILNFYRTGKLHLVDEMCVLAFSDDLEYWG VDELYLESCCQHKYHQRKEHVHE--------------------EMRKEAESLRQREEEEFGEGQCAQYQKWLWDLLEKPT TSIAARVIAVISILFIVLSTIALTLNTIPSMQVNDEKGNFQD------------NPQLAMVEAVCITWFTLEYLLRFSAS PDKWKFFKGGLNVIDLLAILPYYVSLFLVETNKNATDQ----FQDVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRN SYKELGLLMLFLAMGVLIFSSLAYFAEKEEPGTKFISIPETFWWAGITMTTVGYGDIYPTT-PLGKVIGSVCCICGVLVI ALPIPIIVNNFAEFYKNQMRREKALKRREALERAKREGSIVSFHHINLRDAFAKSMDLIDVIVDT--------------- -------------------GHNMSGVDGNSTE-GESACG-RGPAQTGPGCYRNYEHYSLSR------HRRSASS---CFP NLPNDMP-------TTPDSPNRRLLDFAQSVPGTQTDDYFHDDVPAHVNQGN---------------------------T TPSAMSDSAH---------------------------------------------------------------------- --------------------- >Anopheles_gambiae-KCNS1(XP_315955.4) MVGDRDREREAVRWELGETTPPPFNNGG---PGSMCGGTALP-------------------------------------- ---------------------ALGAIGGGAGALPG---------------------SFDDGNAPTTASSIIGPLASVG-- -------GGGSTTG---------LSALSVTGAGPAGSLSGSGPGGASGGGGGAGGGGGGAGSGKEVRYAPFPIQSPTHQA AAMAAGNATNPNYAQMAQAPLQRAHSSFRSRLPRPLTCVFAPTL-RSMSSIPP-EPFMIMRSKALNRRVLINVGGVKHEV LWRTLERLPHTR-LGRLRECNTHEAISELCDDYSLIDNEYFFDRHPKSFSSILNFYRTGKLHLVDEMCVLAFSDDLEYWG VDELYLESCCQHKYHQRKEHVHE--------------------EMRKEAESLRQREEEEFGDGKCAQYQKYLWELLEKPN TSFAARVIAVISILFIVLSTIALTLNTLPSLQSDHN-GTSQD------------NPELAMVEAVCITWFTLEYVLRFSAS PDKWKFFKGGLNIIDLFAILPYFVSLFLLETNKNATDQ----FQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRN SYKELGLLMLFLAMGVLIFSSLAYFAEKDEPQTKFISIPETFWWAGITMTTVGYGDIYPTT-PLGKVIGTVCCICGVLVI ALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLRDAFAKSMDLIDVIVDTGELFRLIYSSLYSSG QGHIYWSDYSSRLDLISIIGHNMSVADGNSTEEGDSVSGGRNPAMTGVGCYKNYKHSAGPRKRVNSQPMMGASLDTEAAP PYSPSMQHHS---MAANDMDAGEEQQLIMQETPQHEPPVMMATRAVCVTCDAP--------------------------V KSHPMLLPPP-------------------FLRFHSHPFFQPSLPPYPFASFPKASVRLEGQNE----------------- --------------------- >Drosophila_melanogaster-KCNS1(FBpp007... MVGERDRDREAVRWATGESTPLQTNNGVLQMVGQLQGGQAAGQQQQQQQATQQQQHSKQQQQQQQQQQQQLQLKQHQQQQ QDILYQQHNEAIAIARGLQAATPADIGDNQPYYDTSGNVDWERAMGAGGAGAYGGIGIGSLPAAGGAAYHLGPANPAGLV SRHLDYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAGTGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSI PTTSQQIVGSVGGVGVGGASSQSISGGVPTHSQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEV LWRTLERLPHTR-LGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWG VDELYLESCCQHKYHQRKENVHE--------------------EMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPN TSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDN-GTPQD------------NPQLAMVEAVCITWFTLEYILRFSAS PDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQ----FQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRN SYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTT-ALGKVIGTVCCICGVLVI ALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDT--------------- -------------------GHNLSQTDGNSTE-GESTSG-RNPATTGTGCYKNYDHVANLRN-SNLHNRRGSSSEQDAVP PYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVATAT NASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVALENLQNQRMDNLEQDVPVEFECCF CTTKGLPGCHGECIPLRANSV >Homo_sapiens-KCNS2(ENSP_287042) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MTGQSLWD--VSE-ANVED-GEIRINVGGFKRRL RSHTLLRFPETR-LGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EKWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPG YSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLNDSLR-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Macaca_mulatta-KCNS2(ENSMMUP_13437) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MTGQSLWD--VSE-ANVED-GEIRINVGGFKRRL RSHTLLRFPETR-LGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EKWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPG YSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLNDSLH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Gorilla_gorilla-KCNS2(ENSGGOP_2752) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MTGQSLWD--VSE-ANVED-GEIRINVGGFKRRL RSHTLLRFPETR-LGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EKWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPG YSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLNDSLH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Mus_musculus-KCNS2(ENSMUSP_58773) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------CLPAGRGSFPPASAAGSRAPRCSAPARRGRLGISSMTRQSLWD--VSD-TDVED-GEIRINVGGFKRRL RSHTLLRFPETR-LGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EKWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPG YSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESSP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLDDSLH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Rattus_norvegicus-KCNS2(ENSRNOP_15707) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MTRQSLWD--LSE-TDVED-GEIRINVGGFKRRL RSHTLLRFPETR-LGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EKWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPG YSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESSP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLDDSLH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Oryctolagus_cuniculus-KCNS2(ENSOCUP_3... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------CSPAGRGSFPPASAAGAGASRCSAPARRVRPGACSMTGQSLWD--ESE-ANFED-GEVRVNVGGFKRRL RSHTLLRFPETR-LGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EQWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGDLRRRLWLALDNPG YSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGE------------DPRFETVEHFGIAWFTFELVARFAVA PEFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLSDSLH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Bos_taurus-KCNS2(ENSBTAP_10214) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------CSPAGRGSFPPASAAGPRARRCSAPARRGRPGVSSMTGQSLWD--VSE-ANVED-GEIRINVGGFKKRL RSHTLLRFPETR-LGRLLLCHSREAILELCDDYDDAQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EKWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPG YSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDRQGNPGE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLNDSLH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Canis_familiaris-KCNS2(ENSCAFP_715) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------CRQAGRGSFPPASAAGPRARRCSAAARHGR-GASSMTRRSPWD--ANE-ANVED-GEIRVNVGGFRRRL RSHTLLRFPETR-LGRLLLCRSREAILELCDDYDDAQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EKWDEQSD------QESTTSSFDEILAFYSDASKFDGQPLGNFRRQLWLALDNPG YSVLSRIFSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LTTIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSINLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLNDSPH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Equus_caballus-KCNS2(ENSECAP_3431) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------N--LSK-PNVED-GEIRINVGGFKKAA AVAYAAALPLRRAWGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EKWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPG YSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSINLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLNDSLH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Pteropus_vampyrus-KCNS2(ENSPVAP_12768) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MTRQSLWD--VSE-ANVED-GEIRINVGGFKRRL RSHTLLRFPETR-LGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKVEPEQ--EKWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGNLRRQLWLALDNPG YSVLSRVFSILSILVVLGSIITMCLNSLADFQIPDSQGNPGE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLNDSLQ-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Monodelphis_domestica-KCNS2(ENSMODP_8... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------LPTMTGQSLSD--LSE-ANFED-SEISVNVGGFKKKL RSHTLLRFPETR-LGRLLHCRSKESILELCDDYDDAQNEFYFDRNPELFPYVLHFYNTGKLHVMGELCVFSFSQEIEYWG INEFFIDSCCSYSYHGRKMEPDQ--EKWDEQSD------QESTTSSFDEILAFYNDASKFDGQPLGNLRRQLWLALDNPG YSILSRVFSILSIMVVLGSIVTMCLNSLPDFLIPDSQGNPEE------------DPRFEIVEHFGIAWFTFELVARFAVT PEFFKFFKNALNLIDLMSIIPFYITLVVNLVVESSP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGT-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAH--KVKSLMASL--------------- ------------------TNMSRSSPSELSLNDSLH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Ornithorhynchus_anatinus-KCNS2(ENSOAN... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ICINVGGLKQKL LPRTVLRFPETR-LGRLLRCGSRAAILELCDDYDDSQGEYYFDRDPRLFPYVLHFYRTGKLHVTGQLCVFSFSQEIEYWG IDELSIDACCGPGYRGRKTEPTAGPDRWEDRSE------RESAASSFDELLAFYRDASRFDGRPLGRLRRRLWLALDNPG RSVPSRAFGVLSVLVVLGSIVTMCLNSLPDY------------------------PRFEAVERFGIAWFTFELLARFAVA PDFSRFFRNALNLIDLLSIVPFYVTLAVNLVAESSP-----ALANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYREVGLLLLYLSVGISIFSVVAYTVEREDDEG-LATIPACWWWATVSMTTVGYGDVVPGT-AAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCRF--GDGTGEVPSVNLRDYYAC--RVKSLMASL--------------- ------------------TDKTRASLSRSRGDADSA-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Gallus_gallus-KCNS2(ENSGALP_28328) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------KPILLMC----CLVQLHS???-------FDRNPELFPYVLHFYNTGKLHVRGELRVFSFSQEIEYWG INEFFIDSCCSYSYHGRKMEPDQ--EKWEEQSD------QESTTSSFDEILAFYNDASKFDKQPFGNIRRQLWLALDNPG YSVLSRIFSVLSIVVVLGSIVTMCLNSLSDFQIIDSSGTPEE------------DPRFEIVEHFGIAWFTFELVARFAVA PDFLKFFQHALNLIDLMSILPFYITLIVNLVVESSP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY SYREVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGS-TAGKLTASACILAGILVV VLPITLIFNKFSHFYR----RQKQLESAMRSCDF--GDGMKEVPSVNLRDYYAY--KVKSLMASL--------------- ------------------TNMSRSTPSELSLNDSL--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Oryzias_latipes-KCNS2(ENSORLP_3496) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------AAWSPGDKDMTGQLLGE--AVGGAHMDDNAAIRINVGGFKKRL KSDTLSRFPETR-LARLLQCRSKESILELCDDYDDTEKEFYFDRNPSLFPYVLNFYNTGRLHVMAELCIFSFSQEIEYWG INEFFIDSCCSSAYHCRKMDQDR--EDWDERSE------EGSTTSSFDELLEFYNDASKFDKQLCGSARRRIWLMLDNPG YSVASRIISVLSICVVLGSIATMCMNSMSEFSLMDSEGQPTE------------DPRFEAVEHFGIGWFTLELVARFVVA PDLLHFFDHPLNAIDLVSILPFYLTLLINLVVESSP-----ALANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLRN SYKEVGLLLLYLAVGVSFFSVIAYTVEKEDSED-LSTIPACWWWATVSMTTVGYGDVVPVS-IAGKLTASACILAGILVV VLPITLIFNKFSLFYK----RQKQ-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Takifugu_rubripes-KCNS2(ENSTRUP_27900) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MTGQVLGE--LHGGASMDDNAGIRINVGGFKKRL QSDTLSRFPETR-LARLLHCRSKESILELCDDYDDAEKEFYFDRNPALFPYVLNFYHTGRLHVMAELCIFSFSQEIEYWG INEFFIDSCCSSTYHCRKMDQDR--EDWDDKSD------EGSTTSSFDELLEFYSDASKFDKQLLGSIRRRVWLMLDNPG YSVASRIISILSILVVLGSIATMCMNSMIEFSLMDSEGQPVE------------DPRFEVVEHFGIGWFTLELVARFAVA PDLLHFFEHPLNVIDLVSILPFYLTLLINLVVESSP-----ALANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLRN SYKEVGLLLLYLAVGVSFFSVIAYTVEKEDNED-LTTIPACWWWATVSMTTVGYGDVVPVS-IVGKLTASACILAGILVV VLPITLIFNKFSLFYK----RQKQLEIAMRSCDF--DEGIKEVPSVNLRNYYAH--KVKSLMASL--------------- ------------------SNMSRSSPSEHSLTESIH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Tetraodon_nigroviridis-KCNS2(ENSTNIP_... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------QFLGK--LHGGASMDDSAAIRINVGGFKKRL QSDTLSRFPETR-LARLLHCRSKESILELCDDYDDAEKEFYFDRNPALFPYVLNFYHTGRLHVMAELCIFSFSQEIEYWG INEFFLDSCCSSTYHCRKMDQDR--EDWDDKSE------EGSTTSSFDELLEFYSDASKFDKQLLGSVRRRIWLMLDNPG YSVASRIISVLSILVVLGSIATMCMNSMSEFSLVDSEGHPTE------------DPRFEIVEHFGIGWFTLELLARFAVA PDLLHFFEHPLNVIDLVSILPFYLTLLINLVVESSP-----ALANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLRN SYKEVGLLLLYLAVGVSFFSVIAYTVEKEDNED-LTTIPACWWWATVSMTTVGYGDVVPVS-IVGKLTASACILAGILVV VLPITLIFNKFSLFYK----RQKQLEIAMRSCDF--NEGIKEVPSVNLRNYYAH--KVKSLMASL--------------- ------------------SNM----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Gasterosteus_aculeatus-KCNS2(ENSGACP_... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MTGQALGE--LRGGTRAHDNAAIHINVGGFKKRL LSHTLSRFPETR-LARLLHCQSKESILELCDDYDDTEKEFYFDRNPALFPYVLNFYNTGRLHVMAELCIFSFSQEIEYWG INEFFIDSCCSSAYHCRKMDQDR--EDWDDRSD------EGSTTSSFDELLEFYSDATKFDKQPLGSARRRVWLMLDNPG YSVASRIISILSILVVLGSIATMCLNSMSEFCLLDDEGLPAE------------DPRFETMEHFGIGWFTLELVARFTVA PDLPHFFEHPLNLIDLVSILPFYLTLLVNLVVESSP-----TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLRN SYKEVGLLLLYLAVGVSFFSVMAYTVEKEDSDD-LSTIPACWWWATVSMTTVGYGDVVPVS-IAGKLTASACILAGILVV VLPITLIFNKFSLFYK----RQKQLEAAMRSCDF--DEGIKEVPPVNLRNYYAH--KVKSLMASL--------------- ------------------SNMSRSSPSEHSLNESIH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Homo_sapiens-KCNS3(ENSP_305824) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------RPGQDEELVNLNVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEENHEK--DWDQKSHDV-----STDSSF-EESSLFEKELEKFDTLRFGQLRKKIWIRMENPA YCLSAKLIAISSLSVVLASIVAMCVHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTGELAVRLAAA PCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVT-LAGKLIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDVDQCSED--APEKCHELPYFNIRDIYA---QRMHTFITS--------------- ------------------LSSVGIVVSDPDSTDASSIEDNEDIC--NTTSLENCTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Macaca_mulatta-KCNS3(ENSMMUP_22621) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------RPGQDEELVNLNVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEENHEK--DWDQKSHDV-----STDSSF-EESSLFEKELEKFDTQRFGQLRKKIWIRMENPA HCLSAKLIAISSLSVVLASIVAMCVHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTGELAVRLAAA PCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVT-LAGKLIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDVDQCSED--VPEKCHELPYFNIRDIYA---QRMHAFITS--------------- ------------------LSSVGIVVSDPDSTDASSIEDNEDIC--NTTSLENCTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Gorilla_gorilla-KCNS3(ENSGGOP_958) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------RPGQDEELVNLNVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEENHEK--DWDQKSHDV-----STDSSF-EESSLFEKELEKFDTLRFGQLRKKIWIRMENPA YCLSAKLIAISSLSVVLASIVAMCIHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTGELAVRLAAA PCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYQEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVT-LPGKLIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDVDQCSED--APEKCHELPYFNIRDIYA---QRMHAFITS--------------- ------------------LSSVGIVVSDPDSTDASSIEDNEDIC--NTTSLENCTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Mus_musculus-KCNS3(ENSMUSP_129412) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------RPGQDEELVNLNVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPFLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSSRYQERKEESHDK--DWDQKSNDV-----STDSSF-EESSLFEKELEKFDELRFGQLRKKIWIRMENPA YCLSAKLIAISSLSVVLASIVAMCVHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTGELAIRLVAA PSQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDEHKSSLTSIPICWWWATISMTTVGYGDTHPVT-LAGKIIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDMEVDQCSED--PPEKCHELPYFNIRDVYA---QQVHAFITS--------------- ------------------LSSIGIVVSDPDSTDASSVEDNEDAY--NTASLENCTGK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Rattus_norvegicus-KCNS3(ENSRNOP_6499) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------RPGQDEELVNLNVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSSRYQERKEESHEK--DWDQKSNDV-----STDSSF-EESSLFEKELEKFDELRFGQLRKKIWIRMENPA YCLSAKLIAISSLSVVLASIVAMCVHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTGELAIRLVAA PSQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDELASSLTSIPICWWWATISMTTVGYGDTHPVT-LAGKIIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDMDVDQCSED--PPEKCHELPYFNIRDVYA---QQVHAFITS--------------- ------------------LSSIGIVVSDPDSTDASSVEDNEDAY--NTASLENCTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Oryctolagus_cuniculus-KCNS3(ENSOCUP_6... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------RPGPDEELVNLNVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEENHEK--DWDQKSNDV-----STDTSF-EESSVFEKELEKFDQLRFGQLRKKIWIRMENPA YCLSAKLIAISSLSVVLASIVAMCVHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTGELAVRLVAA PCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVT-LAGKLIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDVDQCSED--PPEKCPELPYFNIRDLYA---QRVHAFITS--------------- ------------------LSSVGIVVSDPDSTDASSIEDNEDVY--NTASLENCTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Bos_taurus-KCNS3(ENSBTAP_25570) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------RPGPDEELVNLNVGGFKQTV DQSTLLRFPHTR-LGKLLSCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFLDSCCSNRYQERKEENHEK--DWDQKSNDV-----STDSSF-EESSLFEKELEKFDKLRFGQLRKKIWIRMENPA YCLSAKLIAISSLSVVLASIVAMCIHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTGELVIRLVTA PCQKKFWKNPLNIIDFVSIVPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPVCWWWATISMTTVGYGDTHPVT-LVGKLIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDVDQCSED--PPEKCQELPYFNIRDIYA---QRMHAFITS--------------- ------------------LSSVGIMVSDPDSTDASSIEDNEDVY--NTASLENCPPM----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Canis_familiaris-KCNS3(ENSCAFP_5588) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------RPGQDEELVNLNVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEENHER--DWDQKSNDV-----STDSSF-EESSLFEKELEKFEQLRFGQLRKKIWIRMENPA HCLSAKLIAISSLSVVLASIVAMCVHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTGELAIRLVAA PCQKKFWKNPLNIIDFVSVIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDEHTSSLTSIPICWWWATISMTTVGYGDTHPVT-LAGKLIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDVDQCNED--PPEKCQELPYFNIRDIYA---QRMHAFITS--------------- ------------------LSSVGIVVSDPDSTDASSIEDNEDVY--NTASLENCTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Loxodonta_africana-KCNS3(ENSLAFP_17366) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVYGEFFH------RPGQGEELVNLNVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHIMEELCVFSFCQEIEYWG INELFLDSCCSNRYQERKEEKHEK--DWDQKSNDV-----STDSSF-EESSLFEKELEKFDKLRFGQLRKKIWIRMENPA YCLSAKLFAISSLSVVLASIVAMCVHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTGELAIRLVAA PCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEE-----SEDFENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDESMSSLTSIPVCWWWATISMTTVGYGDTHPVT-LAGKLIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDVDQCSED--PPEKCHELPYFNIRDIYA---QRVHAFITS--------------- ------------------LSSVGIVVSDPESTDASSIDNSEDAC--NTASLENCTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Equus_caballus-KCNS3(ENSECAP_23033) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------RPGQDEELVNLNVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEENHEK--DWAQKSNDV-----STDSSF-EESSLFEKELEKFDKLRFGQLRKKIWIRMENPA YCLSAKLIAISSLSVVLASIVAMCVHSMSEFQ---NEDGEVD------------DRVLEGVEIACIAWFTGELVIRLVAA PCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDEHTSSLTSIPICWWWATISMTTVGYGDTHPVT-LAGKLIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDVDQCSED--PPEKCHELPYFNIRDIYA---QRMHAFITS--------------- ------------------LSSVGIVVSDPDSTDASSIEDNEDVY--NMASLENCTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Myotis_lucifugus-KCNS3(ENSMLUP_4651) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------NVGGFKQSV DQSTLLRFPHTR-LGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFQYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEETHEK--DWDQKSNDV-----STDSSF-EESSLFEKELEKFDKLRFGQLRKKIWIRMENPA SCLSAKLIAISSLSVVLASIVAMCIHSMSEFQ---NEDGEVD------------DPVLEGVEIACIAWFTSELAIRLMAA PCQKKFWKHPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLIYSVEKDDDTSSLTSIPICWWWATISMTTVGYGDTHPVT-VPGKLIASTCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDVDPCSED--PAEKGHELPYFNIRDMYA---QRMHAFISS--------------- ------------------LSPVGIVVGDPDSTDASSIEDEEDVY--NMASLENCTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Monodelphis_domestica-KCNS3(ENSMODP_5... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGEFFH------TPGQEEELVNLNVGGFRQSV GQSTLLRFPHTR-LGRLLTCHSEEAILELCDDYSVAEKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKDDNPNK--DWDQKSNDG-----STDSSF-EESSIFEKELEKFDTMRFGNLRKKIWIRMENPA SCLSAKLIAISSLSVVLASIVAMCVHSMAEFQ---KTEDGVE------------NPVLEAVEITCIIWFTGELAIRLVAA PCQKKFWKSPLNIIDFVSIIPFYATLAVDTKNED-----SEDIENVGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLSVGISIFSVLVYSVEKDDAQSGLTSIPICWWWATISMTTVGYGDTHPVT-LVGKLLGSTCIICGILVV ALPITIIFNKFSKYYQ----RQKDVDVDHGSSDE-APEGCNELPYFNIRDIYA---KRVHSFISS--------------- ------------------LSSAGIVASEQDATDASSIDEAEDIY--DTVSLENDTAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Ornithorhynchus_anatinus-KCNS3(ENSOAN... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVFGTIFH------SPGQDEEVVNLNVGGFKQTV DQSTLLRFPHTR-LGKLLRCHSEEAILELCDDYSVAEKEYYFDRNPSLFRYVLNFYYTGKIHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEENSDK--DWDQKSNET-----NSDSSY-EESSIFEKELEKFDKLRFGELRKKIWVRMENPA YSLSAKLIAISSLSVVLASIVAMCIHSMPEFQRRDTNDREME------------DPILEAVEIACIVWFTGELAIRLVAA PCQKKFWKKPLNIIDFVSIIPFYATLAVDRKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYHEVGLLLLFLAVGISIFSVLVYSVEKDDQTSELSSIPICWWWATISMTTVGYGDTYPVT-LAGKLIGSVCIICGILVV ALPITIIFNKFSKYYQ----KQKDMDGDQNCDE--HQEKCNEMPYFNIRDIYA---RRMHSFISS--------------- ------------------LSSVGIVASDQDSTDASSIEDMEDIH--NAASLESGAAK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Gallus_gallus-KCNS3(ENSGALP_26523) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVYGEFFR------RPGKDAELINLNVGGFKQSV DQSTLLRFPHTR-LGKLLKCHSEEAILELCDDYSVADKEYYFDRNPSLFQYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEEGPEK--DWDQKSNDR-----SIDSSN-EESSIFDKELEKFDNLCFGEIRKKIWVRMENPA YCLSAKLIAVSSLSVVLASIVAMCIHSMPEFQRLDANDREIE------------DPVLEAVEIACIIWFTAELVIRLITA PSQKKFWKKPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYQEVGLLLLFLSVGISIFSVLVYSVEKDDDSSELHSIPVCWWWATISMTTVGYGDTYPVT-LAGKLLGTLCIICGILVV ALPITIIFNKFSKYYQ----KQKDIDPDQCNND--RKEKCNDLPYFNIRDIYA---KKMHSFISS--------------- ------------------LSSVGIVVSDQDSTDASSIQDMEDVY--RTTTLDNGAGK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Taeniopygia_guttata-KCNS3(ENSTGUP_13517) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MVYGEFFR------RPGKDAELINLNVGGFKQSV DQSTLLRFPHTR-LGKLLKCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWG INELFIDSCCSNRYQERKEEGPEK--DWDQKSND------SMDSSN-EESSIFDKELEKFDNLCFGEIRKKIWVRMENPA YCLSAKLIAVSSLSVVLASIVAMCIHSMPEFQRLDANDREIG------------DPVLEAVEITCIIWFTAELVIRLFTA PSQKKFWKKPLNIIDFVSIIPFYATLAVDTKEEE-----SEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRH SYQEVGLLLLFLSVGISIFSVLVYSVEKDDDSSELQSIPICWWWATISMTTVGYGDTYPVT-LAGKLLGTLCIICGILVV ALPITIIFNKFSKYYQ----KQKAIDRDQCNND--RKEKSNDLPYFNIRDIYA---KKMHSFISS--------------- ------------------LSSVGIVVSDQDSTDASSIQDMEDVY--NAVSLENGTGK----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Xenopus_tropicalis-KCNS3(ENSXETP_56255) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------QERQSRWNWK------ITKNEEELVKLNVGGFKQSV DQKTLLRFPHTR-LGKLLNCRSEEAILELCDDYNVADKEYYFDRNPSLFRYILNFYYTGKLHVMEELCVFSFSQEIEYWG INELFIDSCCSNKYQEKKEIIAEK--DWDQKSDII-----SLGSSSSDQSSVFERELEMFDTLKFGDIRRKIWIRLENPA YSLSAKLFAIASLSVVLTSIVAMCIHSMPEFKKLDANDRELE------------DPVLAVVEIVCIIWFTSELVIRLIVA PSQKKFWKNPMNIIDFVSIIPFYATLVVDVNDEE-----NEGIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLKH SYHEVGLLLLFLAVGISIFSVLVYYVEKDEDQSGLHSIPMCWWWATISMTTVGYGDTHPVT-LFGKLVGTVCIICGILVV ALPITIIFNKFSKYYQ----KQKAIDVDGCNDDE-QKDKFNDLPYFNIRDIYA---RRMNSFISS--------------- ------------------LSSVGIIASGNDSTDASSI------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Oryzias_latipes-KCNS3(ENSORLP_15655) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MGYGEVLH------HRGNEKDQVHLNVGGVRHRV EAHTLLRFPRTR-LARLLHCQSEDAILELCDDYNPMEREYYFDRNPRVFLCVLNFYHTGRIHMMEEFCVFSFSQEIEYWG IQELHLGPCCNNWYHERKDFIEDR--DWDIRSDDQ---QPSFDSSF-EELSALDKDLEKFKGAWCAEVRSYVWLRLEDPA HSTAAKVIAVASLSVVLTSIIAMCVHSMPEFQRVDDNDKPIE------------DPVLIVLEEICIACFSAEFIIRLIVA PSRKKFLGNPLNIIDVASILPFYATLALQTADEETA-EENEDLENVGRVVQVLRLMRVLRILKLARHSIGLRALGATVRH SYHEVGLLILFLSVGISVFSALIYFAEKEEKDTDLGTIPAGWWWALITMTTVGYGDICPVT-VGGKLVATVSIICGLLVV ALPISVIFNKFSKYYQ----RNKALEGKGITKPE---RQDPELPYYNIRDLFIR--GSVYPFLGS--------------- ------------------IAFRNSVSSTGDNTDASSLQDMEVYDPDNGAAKENCSDA----------------------- --------