>Homo sapines IGFBP4
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLP------------LCLVAALL--------LAAGPGPSLGDEAIHCPPC--------------------------------------------------------------------SEEKLARCR-PPVG-------------------------CEELVREPGCGCCATCALGLG------MPCGVYTPRCGSG------------LRCYPPRGVEKPLHTLMHGQGV------------------------------------CMELAEIEAI----------QESLQPSDKDEGD-HPNNSFSPCSAHDRRCLQKHFA-------------------KIRDRSTSG--------GKMKVNG------APREDARPVPQGSCQSELHRALERLAASQSRTHE------------------------------------------------------------DLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKG---------ELDCHQLADSFRE---------------------------------------------------------------------------------------------------------------------------------------------
>Mus musculus IGFBP4
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLP------------FGLVAALL--------LAAGPRPSLGDEAIHCPPC--------------------------------------------------------------------SEEKLARCR-PPVG-------------------------CEELVREPGCGCCATCALGLG------MPCGVYTPRCGSG------------MRCYPPRGVEKPLRTLMHGQGV------------------------------------CTELSEIEAI----------QESLQTSDKDESE-HPNNSFNPCSAHDHRCLQKHMA-------------------KIRDRS------------KMKIVG------TPREEPRPVPQGSCQSELHRALERLAASQSRTHE------------------------------------------------------------DLFIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKG---------ELDCHQLADSFQE---------------------------------------------------------------------------------------------------------------------------------------------
>Rattus norvegicus IGFBP4
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLP------------FGLVAALL--------LAAGPRPSLGDEAIHCPPC--------------------------------------------------------------------SEEKLARCR-PPVG-------------------------CEELVREPGCGCCATCALGLG------MPCGVYTPRCGSG------------MRCYPPRGVEKPLRTLMHGQGV------------------------------------CTELSEIEAI----------QESLQTSDKDESE-HPNNSFNPCSAHDHRCLQKHMA-------------------KVRDRS------------KMKVVG------TPREEPRPVPQGSCQSELHRALERLAASQSRTHE------------------------------------------------------------DLFIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKG---------ELDCHQLADSLQE---------------------------------------------------------------------------------------------------------------------------------------------
>Xenopus tropicalis IGFBP4
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LHMMSG-----------NCHPALLL--------LVLATFGMAEDAAIQCPPC--------------------------------------------------------------------SQEKLIRCT-DPVG-------------------------CQELVKEPGCGCCATCALPKG------APCGVYTARCGTG------------LRCYPPRGSEKPLHTLMHGQGL------------------------------------CTEIGEIESI----------TETFPKTGEYIAVGRGQTSQTVWMHHNQIAVFVYFT-------------------LGPMPNGCLGFSLVLIILSIRLSS------HLHHHKKGEDEGVCQKDLNRALEKLAAYQTRTQE------------------------------------------------------------DFLSIPIPNCDRNGNYNPKQCHPALDGQRGKCWCVDRKTGVKLHIPYDPVL---------DADCQVASERGK----------------------------------------------------------------------------------------------------------------------------------------------
>Tetraodon nigroviridis IGFBP4
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIRGSAVALASSCWGFWAFSALS--------LAA---LCLSDQAIRCPVC--------------------------------------------------------------------SEERLARCR-LPEG-------------------------CEETVREPGCGCCPTCALAKG------AHCGVYSPRCGTG------------LRCYPPRGVERPLHSLMHGQGV------------------------------------CTDEREVEE-----------NSATDRQDEIIPE-HPNNSNIRCSQQDKRCIQKTLA-------------------RHLSKS------------TNQRSN------SGREETKAVLAP-CRAELQRALDRLASN-TRTHD------------------------------------------------------------DLFTIPIPNCDKNGDFHIKQCHPARDGQRGKCWCVDQKTGMRLPGPLEPRG---------DLDCHQLT--------------------------------------------------------------------------------------------------------------------------------------------------
>Takifugu rubripes IGFBP4
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIPGRAVALASSCWGFWAFSALS--------LVA---LCLSDQAIRCPVC--------------------------------------------------------------------SEERLARCR-LPEG-------------------------CEETVREPGCGCCPTCALAKG------AHCGVYSPRCGTG------------LRCYPPRGVERPLHSLMHGQGV------------------------------------CTDEREVEE-----------NSAMDRQDEIIPE-HPNNSNIRCSPQDKRCIQKTLA-------------------RHPPKS------------TNQRSN------TAREETKAVLAP-CRAELQRALDRLASN-TRTHD------------------------------------------------------------DLFTIPIPNCDKNGDFHIKQCHPARDGQRGKCWCVDQKTGMRLPGPLELRG---------DLDCHQL---------------------------------------------------------------------------------------------------------------------------------------------------
>Homo sapines IGFBP1
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEVP------------VARVWLVLLLL--------TVQVGVTAGAP--WQCAPC--------------------------------------------------------------------SAEKLALCPPVSAS-------------------------CSEVTRSAGCGCCPMCALPLG------AACGVATARCARG------------LSCRALPGEQQPLHALTRGQGA------------------------------------CVQESDASAP-----------HAAEAGSPESPE-STEITEEELLDNFHLMAPSEED-------------------HSILWDAISTYD------GSKALH------VTNIKKWKE---PCRIELYRVVESLAKAQETSGE------------------------------------------------------------EISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRG---------DPNCQIYFNVQN----------------------------------------------------------------------------------------------------------------------------------------------
>Mus musculus IGFBP1
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPEFL------------TVVSWPFLILL--------SFQIGVAAGAPQPWHCAPC--------------------------------------------------------------------TAERLGLCPPVPAS-------------------------CPEISRPAGCGCCPTCALPMG------AACGVATARCAQG------------LSCRALPGEPRPLHALTRGQGA------------------------------------CVPEPAAPATSTLFSSQHEEAKAAVVSADELSE-SPEMTEEQLLDSFHLMAPSRED-------------------QPILWNAISTYS------SMRARE------IADLKKWKE---PCQRELYKVLERLAAAQQKAGD------------------------------------------------------------EIYKFYLPNCNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRG---------DPNCHQYFNVHN----------------------------------------------------------------------------------------------------------------------------------------------
>Rattus norvegicus IGFBP1
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPEFL------------TVVSWPFLILL--------SFQVRVVAGAPQPWHCAPC--------------------------------------------------------------------TAERLELCPPVPAS-------------------------CPEISRPAGCGCCPTCALPLG------AACGVATARCAQG------------LSCRALPGEPRPLHALTRGQGA------------------------------------CVLEPAAPATSSLSGSQHEEAKAAVASEDELAE-SPEMTEEQLLDSFHLMAPSRED-------------------QPILWNAISTYS------SMRARE------ITDLKKWKE---PCQRELYKVLERLAAAQQKAGD------------------------------------------------------------EIYKFYLPNCNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRG---------DPNCHQYFNVQN----------------------------------------------------------------------------------------------------------------------------------------------
>Xenopus tropicalis IGFBP1
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAREN------------ISCCSLLATLL--------FIAAAIVVAEP--LHCAQC--------------------------------------------------------------------TEERLASCPSVPND-------------------------CPELAREPGCGCCLTCALKRG------EPCGVYTARCGKA------------LSCHPKAGESRPLYALTRGQGI------------------------------------CMDAEDLKKLR---ASDAADGKDYTEHENVAPE-VSDISHDQIPP-FLRLFPEGLD-------------------KLDPWNAITVY--------EKARK------LLERRKWKEHQGPCQKDLYKTMDKLVKAQQRPGE------------------------------------------------------------DVFKFHIPNCNRNGFYHSKQCEASLDGERGKCWCVFPLTGKRIPGSPENRG---------ELNCQQYLNVQE----------------------------------------------------------------------------------------------------------------------------------------------
>Takifugu rubripes IGFBP1
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATG--------ALGSPVVGPEP--IRCAPC--------------------------------------------------------------------SPERLSQCPAVAPG-------------------------CAEVLREPGCGCCLACALPAG------ELCGIYTAPCGSG------------LRCTPRPGDPRPLHSLTRGQAV------------------------------------CTASAEPQSTP--------EPQQTQDQAEPEPE-IENTVIVTDLSSSHYL-PGHST-------------------PYDPRASADAQE------SMKAKV------IAIRKKLVE-QGPCHLELQRALDKIATSQQRPGE------------------------------------------------------------KLTRFYLPNCDKHGLYKPKQCESSLDGQRGRCWCVNSWNGKKTSGVSEVPV---------DAECP-----------------------------------------------------------------------------------------------------------------------------------------------------
>Homo sapines IGFBP2
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPRVGCPALPLPPPPLLPLLLLLLG--------ASGGGGGARAEVLFRCPPC--------------------------------------------------------------------TPERLAACGPPPVAPPAAVA----------AVAGGARMPCAELVREPGCGCCSVCARLEG------EACGVYTPRCGQG------------LRCYPHPGSELPLQALVMGEGT------------------------------------CEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMK-------------------ELAVFREKVTEQHRQ---MGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLE--------------------------------------------------------HLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRG---------DPECHLFYNEQQEARGVHTQRMQ-----------------------------------------------------------------------------------------------------------------------------------
>Mus musculus IGFBP2
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPRLGGPALPLLLPSLL--LLLLLG--------AGGCGPGVRAEVLFRCPPC--------------------------------------------------------------------TPERLAACGPPPDAP------------------------CAELVREPGCGCCSVCARQEG------EACGVYIPRCAQT------------LRCYPNPGSELPLKALVTGAGT------------------------------------CEKRR---VGTTPQQVADSDDDHSEGGLVENHVDGTMNMLGGGSSAGRKPLKSGMK-------------------ELAVFREKVNEQHRQ---MGKGAK-HLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLE--------------------------------------------------------HLYSLHIPNCDKHGRYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRG---------DPECHLFYNEQQETGGAHAQSVQ-----------------------------------------------------------------------------------------------------------------------------------
>Rattus norvegicus IGFBP2
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPRLGGPALPLLLPSLL--LLLLLG--------AGGCGPGVRAEVLFRCPPC--------------------------------------------------------------------TPERLAACGPPPDAP------------------------CAELVREPGCGCCSVCARQEG------EACGVYIPRCAQT------------LRCYPNPGSELPLKALVTGAGT------------------------------------CEKRR---VGATPQQVADSEDDHSEGGLVENHVDGTMNMLGG-SSAGRKPPKSGMK-------------------ELAVFREKVNEQHRQ---MGKGAK-HLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLE--------------------------------------------------------HLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRG---------DPECHLFYNEQQENDGAHAQRVQ-----------------------------------------------------------------------------------------------------------------------------------
>Xenopus tropicalis IGFBP2
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RCWIWKPRQRRG------------TACPNWPVX-LPLQALVLGLGT------------------------------------CGKRRDTEYGSSQERGTELPEERSDNMLVDNKLEAGP-AVAG-EAAPRKPSKKEMK-------------------EIAVTRERANEQQR-----SKSNK-----SEDKKR---PARSLCQLQLDQVLERISGMHLPDDRGPLE--------------------------------------------------------HLYALHIPNCDKNGFFNLKQCKMSVNGQRGECWCVNPITGKALPGSPTIRG---------DPECHLYYTSPEEGR-AHTQRAP-----------------------------------------------------------------------------------------------------------------------------------
>Takifugu rubripes IGFBP2
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLYVSCN-------------LLIIS--------ASLAG-ASLAEMVFRCPGC--------------------------------------------------------------------TAERQALCPKLTET-------------------------CAEIVREPGCGCCPVCARQEG------EMCGVYTPRCATG------------LRCYPTPNSELPLEQLVQGQGQ------------------------------------CRHKVDTEAATYSQE----QREQTSGEAVEAPPEQGMSDIPAIRKPSKDATWMSPK-------------------ESAVRQHRQDLKTK-----MKTNK----VEEVKPAQ--PKQTLCQQELDQILERISKMPFRDNRGPLE--------------------------------------------------------DLYALHIPNCDKRGQYNLKQCKMSLHGQRGECWCVNPHTGRPIPSAPTVRG---------DPNCSQYLAE------------------------------------------------------------------------------------------------------------------------------------------------
>Tetraodon nigroviridis IGFBP2
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLYAGCS-------------LLILS--------ASLAG-ASLAEMVFRCPGC--------------------------------------------------------------------TAERQALCPKLTET-------------------------CAEIVREPGCGCCPVCARQEG------EMCGVYTPRCATG------------LRCYPTPNSELPLEQLVQGQGQ------------------------------------CRRKVDTEAATYSQE----QREQTSGEVVEPPPELGVSDLPAIRKPSKDAAWMGPK-------------------ESAVRQHRQELKTK-----MKTNK----VEEVKTSR--PKQTLCQQELDQILERISKMPFRDNRGPLE--------------------------------------------------------DLYALHIPNCDKRGQYNLKQCKMSLHGQRGECWCVNPHTGRPIPSAPTVRG---------DPNCSQYLTE------------------------------------------------------------------------------------------------------------------------------------------------
>Homo sapines IGFBP3
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPC--------------------------------------------------------------------DARALAQCAPPP-------------------------AVCAELVREPGCGCCLTCALSEG------QPCGIYTERCGSG------------LRCQPSPDEARPLQALLDGRGL------------------------------------CVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGS----VESPSVSSTHRVSD----------PKFHPLH--SKIIIIKKGHAKDSQRYKVDYES--QSTDTQNFSSESKRE-TEYGPCRREMEDTLNHLKFLNVLS---------------------------------------------------------------PRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKY-GQPLPGYTTKGKE--------DVHCYSMQSK------------------------------------------------------------------------------------------------------------------------------------------------
>Mus musculus IGFBP3
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHPARPALWAAALTALTLLRGPPVAELAAGAVG-GPVVRCEPC--------------------------------------------------------------------DARAVSQCAPPPTA-----------------------PACTELVREPGCGCCLTCALREG------DACGVYTERCGTG------------LRCQPRPAEQYPLRALLNGRGF------------------------------------CANASAAGSLSTY-LPSQPAPGNISESEEEHNAGS----VESQVVPSTHRVTD----------SKFHPLH--AKMDVIKKGHARDSQRYKVDYES--QSTDTQNFSSESKRE-TEYGPCRREMEDTLNHLKFLNVLS---------------------------------------------------------------PRGVHIPNCDKKGFYKKKRCRPSKGRKQSFCWCVDKY-GQRLPGYDTKGKD--------DVHCLSVQSQ------------------------------------------------------------------------------------------------------------------------------------------------
>Rattus norvegicus IGFBP3
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRCEPC--------------------------------------------------------------------DARALAQCAPPPTA-----------------------PACTELVREPGCGCCLTCALREG------DACGVYTERCGTG------------LRCQPRPAEQYPLKALLNGRGF------------------------------------CANASAASSLSAY-LPSQPSPGNTTESEEDHNAGS----VESQVVPSTHRVTD----------SKFHPLH--SKMEVIIKGQARDSQRYKVDYES--QSTDTQNFSSESKRE-TEYGPCRREMEDTLNHLKFLNVLS---------------------------------------------------------------PRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKY-GQPLPGYDTKGKD--------DVHCLSVQSQ------------------------------------------------------------------------------------------------------------------------------------------------
>Danio rerio IGFBP3
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTGLCALCLTAL-------LAAFARLAESVSPVVRCEPC--------------------------------------------------------------------DDGAMVLCKPLP-------------------------WDCDEPVKEPGCGCCLTCPLTEG------QACGVYTGRCGTG------------LSCQHRPGESKPLQALLEGRGV------------------------------------CAKAPDKKQSGSPSHGHDKPETEGKEQNGTRTAGTGEAETVHHTTDISRDVQGGSRTPS----EPSDPMMHSNKLEMIQKEQVKKSQVHKVVPFSGWIVQDIHNFSLESKRE-NEYGPCRREMESVMKQLKFTNVLN---------------------------------------------------------------PRRFRIPNCDQKGFYKKKQCSPSKGRKRGHCWCVDKY-GQPLPGYDGKEK----------VHCYNMETK------------------------------------------------------------------------------------------------------------------------------------------------
>Takifugu rubripes IGFBP3
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGAVGPVIKCEPC--------------------------------------------------------------------DAGARLLCKPLP-------------------------KDCVEKVREPGCGCCLTCALRFG------QPCGVYTSRCGSG------------LTCQHQPGETKPLQALLEGRGI------------------------------------CVNATNKRLTPRPTAPVNELPAENIETQDEERNST---SSGLQTPDSTHRPMG---SPR----PPLNPFLPSAKSDVLRREQ-KRIQSFKMEELPGPLITDQQNFSVETKQE-PDYGPCRREIESILSGLKITDILN---------------------------------------------------------------PRGFRIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKY-GQPLPGFDGKERG--------DAQYYNSETQ------------------------------------------------------------------------------------------------------------------------------------------------
>Tetraodon nigroviridis IGFBP3
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGAVGPVIKCEPC--------------------------------------------------------------------DAGARLLCKPLP-------------------------KDCVEKVREPGCGCCVTCALPFG------QPCGIYTSRCGSG------------LTCQHQPGETKPLQALLEGRGI------------------------------------CVNATNKRLTPKPTPPVNELPAENIETQEEERNST---SSGLQTPDSTHRPMG---SPR----PPLNPFLPSAKSDVLRREQ-KRTQSFKMEELPGPLITDQQNFSVETEQE-PDYGPCRREIESILSGLKITDILN---------------------------------------------------------------PRGFRIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKY-GQPLPGFHGKERA--------DAQYYNSETQ------------------------------------------------------------------------------------------------------------------------------------------------
>Homo sapines IGFBP5
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLLTAVLLLL--------AAYAGPAQSLGSFVHCEPC--------------------------------------------------------------------DEKALSMCPPSP--------------------------LGCELVKEPGCGCCMTCALAEG------QSCGVYTERCAQG------------LRCLPRQDEEKPLHALLHGRGV------------------------------------CLNEKSYR-EQVKIERDSREHEEPTTSEMAEETYS-----PKIFRPKHTRISE-------------------LKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQE-SEQGPCRRHMEASLQELKASPRMV---------------------------------------------------------------PRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKY-GMKLPGMEYVDG---------DFQCHTFDSSNVE---------------------------------------------------------------------------------------------------------------------------------------------
>Mus musculus IGFBP5
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVISVVLLLL--------AAYAVPAQGLGSFVHCEPC--------------------------------------------------------------------DEKALSMCPPSP--------------------------LGCELVKEPGCGCCMTCALAEG------QSCGVYTERCAQG------------LRCLPRQDEEKPLHALLHGRGV------------------------------------CLNEKSYG-EQTKIERDSREHEEPTTSEMAEETYS-----PKVFRPKHTRISE-------------------LKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQE-SEQGPCRRHMEASLQEFKASPRMV---------------------------------------------------------------PRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKY-GMKLPGMEYVDG---------DFQCHAFDSSNVE---------------------------------------------------------------------------------------------------------------------------------------------
>Rattus norvegicus IGFBP5
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVISVVLLLL--------AACAVPAQGLGSFVHCEPC--------------------------------------------------------------------DEKALSMCPPSP--------------------------LGCELVKEPGCGCCMTCALAEG------QSCGVYTERCAQG------------LRCLPRQDEEKPLHALLHGRGV------------------------------------CLNEKSYG-EQTKIERDSREHEEPTTSEMAEETYS-----PKVFRPKHTRISE-------------------LKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQE-SDQGPCRRHMEASLQEFKASPRMV---------------------------------------------------------------PRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKY-GMKLPGMEYVDG---------DFQCHAFDSSNVE---------------------------------------------------------------------------------------------------------------------------------------------
>Xenopus tropicalis IGFBP5
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEMLVPALLLV--------SLCLGQCQALGSFVHCEPC--------------------------------------------------------------------DDKAMSMCPPTP--------------------------VGCELVKEPGCGCCMTCALAEG------HRCGVYTEHCAKG------------LRCLPEQGEEKPLHALLHGRGV------------------------------------CLNLKNHR-DQSKIGSQN-SIEEPTTSET-DDLYP-----SKHRG--KMRLTD-------------------QKAIALNTFRQKKQSQSRIVS-VEKVQSP---STPEHKMVPIVAGPCRRQVETLMQEMKLSHRVY---------------------------------------------------------------PRAFYLPNCDRKGFFKRKQCKPSRGRKRGLCWCVDKY-GLKLPGIDYVNG---------DLQCHSFDSSNTE---------------------------------------------------------------------------------------------------------------------------------------------
>Tetraodon nigroviridis IGFBP5
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLRVSLLLP--------LLCLRGGG--ASFVPCQPC--------------------------------------------------------------------DQKALSMCPPVP--------------------------VGCQLRARS--------KRASR------AACTPG--PCTRG------------LRCLPKNGEEKPLHALLHGRGA------------------------------------CRNEKLYKLMHPSKEGD--PRDESMLP--VPDFQT-----KVPLYGR-DHVNS-------------------RKVQAMKQAKDRRK-QLARPGTGSLDFSPLSLDKLEPDFSVVQG-PCRRRLDNLLQSMKDTSRVL---------------------------------------------------------------ALSLYIPNCDKKGFFKRRQCKPSRGRRRGICWCVDRF-GVKIPGINYAGG---------DLQCKEHESSSN----------------------------------------------------------------------------------------------------------------------------------------------
>Danio rerio IGFBP5
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALLVLGTFLT--------VLSVSGG----SFVPCEPC--------------------------------------------------------------------DQKALSMCPPVP--------------------------VGCQLVKEPGCGCCYTCALAEG------QACGVYTGTCTHG------------LRCLPRNGEEKPLHALLHGRGV------------------------------------CTNEKGYKPPHPPIDRESIEHDDTVKPDTTEDQIP-----KIPLYPKPDVINS-------------------KKQAALFKDKKKQQ-EKLRS-VGSLDYSPLPIDKHEPEFG-----PCRRKLDGIIQSMKDTSRVM---------------------------------------------------------------ALSLYLPNCDRKGFFKRKQCKPSRGRKRGICWCVDKY-GVQLPGTDYSGG---------NIQCKDLENSNNNNE-------------------------------------------------------------------------------------------------------------------------------------------
>Takifugu rubripes IGFBP5
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLRVSLLLP--------LLCLRGCG--ASFVPCQPC--------------------------------------------------------------------DQKAQSMCPPVP--------------------------LGCQLRARS--------KRASR------AACTP---PCTRG------------LRCLPKNGEEKPLHALLHGRGA------------------------------------CRNEKLYKLMHPSKDGE--ARDASMLP--VPDFQT-----KVPLYGR-DHINS-------------------RKVQAMKQAKDRKK-QLARLGTGNLDFSPLSVDKLEPDFVSEFGGPCRIRLDNLLQSMKDTSRVL---------------------------------------------------------------ALSLYIPNCDKKGFFKRRQCKPSRGRRRGICWCVDRF-GVKIPGINYAGG---------DLQCKEHESSSN----------------------------------------------------------------------------------------------------------------------------------------------
>Homo sapines IGFBP6
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTPHRLLP-PLLLL--------LALLLAASPGGALARCPGC--------------------------------------------------------------------GQGVQAGCPGGCV------------------------EEEDGGSPAEGCAEAEGCLRREG------QECGVYTPNCAPG------------LQCHPPKDDEAPLRALLLGRGR------------------------------------CLPARAPA----------VAEENPKESKP--------------------------------------------QAGTARPQDVNRRDQQRNPGTSTTPSQPNSAGVQDTEMG-----PCRRHLDSVLQQLQTEVYRG---------------------------------------------------------------AQTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRM-GKSLPGSPDGNG---------SSSCPTGSSG------------------------------------------------------------------------------------------------------------------------------------------------
>Mus musculus IGFBP6
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTWDGLPTQPLLML--------LMLLFAAGSGSALAGCPGC--------------------------------------------------------------------GPGMQTGCRGGCV------------------------EEEDAGSPADGCTEAGGCLRREG------QPCGVYSPKCAPG------------LQCQPRENEETPLRALLIGQGR------------------------------------CQRARGP------------SEETTKESKP--------------------------------------------QGGASRSRDTNHRDRQKNPRTSAAPIRPN--PVQDSEMG-----PCRRHLDSVLQQLQTEVFRGG--------------------------------------------------------------ARGLYVPNCDLRGFYRKQQCRSSQGNRRGPCWCVDPM-GQPLPVSPDGQG---------STQCSARSSG------------------------------------------------------------------------------------------------------------------------------------------------
>Rattus norvegicus IGFBP6
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTWDGLPTQPLLML--------LMLLFAAGSESALAGCPGC--------------------------------------------------------------------GPGVQ---------------------------------EEDAGSPADGCAETGGCFRREG------QPCGVYIPKCAPG------------LQCQPRENEETPLRALLIGQGR------------------------------------CQRARGP------------SEETTKESKP--------------------------------------------HGGASRPRD---RDRQKNPRTSAAPIRPS--PVQDGEMG-----PCRRHLDSVLQQLQTEVFRGG--------------------------------------------------------------ANGLYVPNCDLRGFYRKQQCRSSQGNRRGPCWCVDPM-GQPLPVSPDGQG---------SSQCSARSSG------------------------------------------------------------------------------------------------------------------------------------------------
>Ciona intestinalis IGFBP
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVHQNIISSLLFML-------WTVIVKCHDVSICVDLCPAC--------------------------------------------------------------------FTQRMQNCPPLP--------------------------DCELKVRDPGCGCCFTCAAGAG------DRCGINKPRCGPG------------LKCLA-VGAESNLIAILENRGA------------------------------------CQLDPAHQET----------TEKASRLRLIHTR------------------------------------------HLKRRRRKKHRRFPR-------------HPHRGLLSPLNHDGPCSRHYEEMMTSCITMAHKV-------------------------------------------------------------------WLPACDARGYYAAKQCMSSNGLERGKCWCVDET-GIALEDTPYTRD---------SITCHR----------------------------------------------------------------------------------------------------------------------------------------------------
>Ciona savignyi IGFBP
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYILFAIVAVALIG--------DPAASAPASRFAMKCPVC--------------------------------------------------------------------SAEELNACPVLEAG------------------------PTCEIVAEPNCGCCSMCAKLES------EECGVAKGYCGSG------------LTCAPLIYEYEGEVYFS--EHV------------------------------------CMTDADLDRMFGEVITPPLEDPESHQNGEAQDT------------------------------------------TLSPTTTT----------------------VIPTQEAHVPEGPCDQHWERVWSKTFFAKHEW--------------------------------------------------------------------VPECDREGYYSPQQCEVAYGLELGKCWCVDKLGNRQTDKMVDSPS----------FQC------------------------------------------------------------------------------------------------------------------------------------------------------
>Strongylocentrotus purpuratus (XP_793433)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAIDSSCFLEHKLRQNSRAITGTLLAILIMLSDASVSFATRLNPENTQTQNPECNMDCSNQRPKPFCG----------------------------------------------------TDGRTYLSKCEVKKARCQG--------------------WNVRKEHNGPCAVELTKCQLERAQNLQQPDSSSLFVPQCNDDGSYAMIQCHKSFGYCWCVTEEGKPIAGSSVREGNP----------------------------------TCNRQADEPIVDNPPTFKGTSSSSGGSRCRQDKREEFNKNLKRIFKEEYARLPRADIAPIPFSSSRATLEWEKQVIEWKFGSLDENEDANLDSKELKPLLRLMKKIIKPKVCAKDFVKICDLDADDRLTEMEWSLCLGVDNNEQPEEPTVDSGGPQDASPPLLVTRQIPHGDNADSDNQNVPVLSCETERLRALEEQERTSASVVFVPQCTITGDYMAVQCH----EQMQYCWCVYVDTGKPIPGTSVRDST--------KEDCSPLATSRGPITPRVFVDCPDDKKKRFLIKLIEKLYAEMTVTDALLIETTTQAAEDLSPNHKDESIVWKFGQLDRNGNNYLEAKETATFATEIDLIKSSKKCRNNFLDFCDANQDSRLALKEWLHCFDITPPVATEAPPRRGRNPFIDRLT
>Drosophila melanogaster(CG13830-PA)
-------------------------------------------------------------------------------------------MKHSPLIASACLALVLMSSSLIGSTEARNKKKYVGETGGDFEFIDEINKNTQSNKNLGEHKRWI-----HDPSSDLCRPLNCKKREICLLEDEFSAVCVSKKELHKNRDEIITKAKYLEEEAKRRVNQQDNQDSQDAEDINNDDEDNSSDGGSSNSSPTG----------TNNAQASVQGNEETDDEDKSLSLGDDDESKEDDVFYENSIAAGDKQQQQQQLSQPAAGPSVIQQD--------------------------------------------------------------------DDEELDNCKPCPVAKPTFLCGADNRTYSSLCRLDYHNCIHSTSIRIACKGFCPCKEIVDGK---RLQRISGYNNKYNKK------------ISLDQQQQQQQQQQQQQQQQQAYKDSNNNNIMMNSGNIMGGNNNDFNTIMNLNFWYWYCRTKRTITGTTTTSMPSTLSRPRRSNMTTSTTSTSSTRPTRRTPSTRRTSTRCATITRW----SRSSSRTYPSKSAECKPQQLTAIGNRLLDWFSVIMADSKKRRQHSQKSKAHFPPACKTEAKWMFGHLDLNNDGQLSLQEMYDLEHDQNERCIKPFIDTCDLDTDSS----INTREWCRCFEKTDRPCAAVRRRIAGDFAGAYAPDCDIQGFYKPTQCHNSVG----VCWCVDKH-GVEFANTRTRGKPNCAFKPAFMAQCWHNSAAAMLEPANGSENTSHSESVVNNAASLTSDDEDEGADDEDSAEGSADQMLVF----------------------------------------------------------------------------------------------
>Appis mellifera (XP_393267)
MTLLTLHVLRCRGLNKLANPLRLTITGSLIKSRSCSVFKKYAKKMSYTTIERGALNSTDYRIYFRNDVGPISPMHDIPLYADESNKILNMVVEIPRWTNAKMEINLKETLNPIKQDVKKGKLRYVANCFPHHGYIWNYGALPQTWENPEVLDEATGCKGDNDPIDVLEIGYKVAKRGEILKVKVLGCVALIDEGETDWKIIVIDVNDPLAEQMNDVSDIEKHYPGLMKATIEWFKIYKIPDGKPENQFAFNGEAKSRDFALHIVEEVHQHWQNLIKREAPAGGIACTNTTVSGSPFKTTIETAEEVLEKAAELSEPQSVDPIGELCRPLNCKKKDLCLLKDTFTAVCVSKKELEKSGDIVIPKSRAVQQNRRMRTETSVDTEDDDAFFDSEDDDEDQDESKCQECPVVKP------------------TFLCGSDNRTYSSPCRLEYHNCIHHTS---VRIACKGFCPCKASD------------LRAHNKKMQLQRQKALSGKMRNRD-------------------------------ITLTPHVFNYDNHHYQYLKYSKRAKALAGSKYDDKHLMSNEVMEKTPSPLKSTYNSQSS-----------------RNSDCPPSSKPAMANRLLDWFSVVMADS-KHRRPHPKPKGHFPIGCQSEVRWMFGHLDSDNDGRLSLSELYGLEHDQNEPCLKPFLDGCDTDRDIF----VSGPEWCG----CFSKAERPCAAVRKRSSPDVAPACDSRGYYRSTQCHRGLG----LCWCVDPH-GVEFAGTRTRGS---------KPDCDTIVNKISNGGLKTNSVDLD-------------DDEDGGTDSAQDLEGSADQPLDF----------------------------------------------------------------------------------------------