>Homo_sapiens_SLC5A1 -------------------------------------------------------------------------------- ----------------MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVG--LWAMFSTNRG--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWN------------------ --------ALVLVVVLGWLFVPIYIKAG-VVTMPEY---LRKRFGGQRIQVYLSLLSLLLY---IFTKISADIFSG---A IFINLALGLNLYLAIFLLLAITALYTIT---GGLAA-VIYTDTLQTVIMLVGSLILTGFA--FHEVGGYDAFMEKYMKAI PT---IVSDGN---TTFQEKCYT------PRADSFHIFRDPLTGDLPWPGFIFG-MSILTLWY--WCTD-QVIVQRCLSA KNMSHVKGGCILCGYL--KLMPMFIMVMPGMISRILYT----------------EKIACVVPSECEKYCG-TKVGCTNIA YPTLVVELM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY AKVRKRAS-------------EKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFW KRVNEP---GAFWGLI-LGLLIGISRMITEFAYGTGSC------------------------------------------ ---MEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYR-----LCWSLRNSKEER-----IDLDA--- -------------------------------------------------------------EEENIQEGPKETIEIETQV PEKKKGIFRRAYDLFCGLEQHGAPKMTE----EEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA------ -------- >Mus_musculus_SLC5A1 -------------------------------------------------------------------------------- ----------------MDSSTLSPAVTATDAPIPSYERIRNAADISVIVIYFVVVMAVG--LWAMFSTNRG--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFEWN------------------ --------ALVLVVVLGWIFVPIYIKAG-VVTMPEY---LRKRFGGKRIQIYLSVLSLLLY---IFTKISADIFSG---A IFINLALGLDIYLAIFILLAITALYTIT---GGLAA-VIYTDTLQTAIMLVGSFILTGFA--FNEVGGYEAFMDKYMKAI PT---KVSNGN---FTAKEECYT------PRADSFHIFRDPITGDMPWPGLIFG-LAILALWY--WCTD-QVIVQRCLSA KNMSHVKAGCTLCGYL--KLLPMFLMVMPGMISRILYT----------------EKIACVLPEECQKYCG-TPVGCTNIA YPTLVVELM---PNGLRGLMLSVMMASLMSS--------------------------------LTSIFNSASTLFTMDIY TKIRKKAS-------------EKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFC KRVNEQ---GAFWGLI-LGFLIGISRMITEFAYGTGSC------------------------------------------ ---MEPSNCPKIICGVHYLYFAIILFVISVITILIISFLTKPIPDVHLYR-----LCWSLRNSKEER-----IDLDAG-- -------------------------------------------------------------EEEDIPEDSKDTIEIDTEA PQKKKGCFRRAYDLFCGLDQDKGPKMTK----EEEEAMKMKMTDTSEKPLWRTVVNINGIILLAVAVFCHAYFA------ -------- >Pan_troglodytes_SLC5A1 -------------------------------------------------------------------------------- ----------------MDSSTWSPTTTAVTRPVETHELIRNAADISIIVIYFVVVMAVG--LWAMFSTNRG--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWN------------------ --------ALVLVVVLGWLFVPIYIKAG-VVTMPEY---LRKRFGGQRIQVYLSLLSLLLY---IFTKISADIFSG---A IFINLALGLNLYLAIFLLLAITALYTIT---GGLAA-VIYTDTLQTVIMLVGSLILTGFA--FHEVGGYDAFMEKYMKAI PT---IVSDGN---TTFQEKCYT------PRADSFHIFRDPLTGDLPWPGFIFG-MSILTLWY--WCTD-QVIVQRCLSA KNMSHVKAGCILCGYL--KLMPMFIMVMPGMISRILYT----------------DKIACVVPSECEKYCG-TKVGCTNIA YPTLVVELM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY TKVRKRAS-------------EKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFW KRVNEP---GAFWGLI-LGFLIGISRMITEFAYGTGSC------------------------------------------ ---MEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYR-----LCWSLRNSKEER-----IDLDA--- -------------------------------------------------------------EEENIQEGPKETTEIETQV PEKKKGIFRRAYDLFCGLEQQGAPKMTE----EEEKAMKMKMTDTSEKPLWRTVMNVNGIILVTVAVFCHAYFA------ -------- >Gorilla_gorilla_SLC5A1 -------------------------------------------------------------------------------- ----------------MDSSTWSPTTTAVTRPVETHELIRNAADISIIVIYFVVVMAVG--LWAMFSTNRG--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWN------------------ --------ALVLVVVLGWLFVPIYIKAG-VVTMPEY---LRKRFGGHRIQVYLSLLSLLLY---IFTKISADIFSG---A IFINLALGLNLYLAIFLLLAITALYTITACLGGLAA-VIYTDTLQTMIMLVGSLVLTGFA--FHEVGGYDAFMEKYMKAI PT---IVSDGN---TTFQEKCYT------PRADSFHIFRDPITGDLPWPGFIFG-MSILTLWY--WCTD-QVIVQRCLSA KNMSHVKAGCIMCGYL--KLMPMFIMVMPGMISRILYT----------------DKIACVVPSECEKYCG-TKVGCTNIA YPTLVVELM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY TKVRKRAS-------------EKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFW KRVNEP---GAFWGLI-LGFLIGISRMITEFAYGTGSC------------------------------------------ ---MEPSNCPTIICGVHYLYFAIILFAISVITIVVISLLTKPIPDVHHSV----SKCGSLTNASQEIKP---TVFSA--- -------------------------------------------------------------PQSQTLQSTFPFLQVKTQV PEKKKGIFRRAYDLFCGLEQQGAPKMTE----EEEKAMKMKMTDTSEKPLWRTVMNVNGIILVTVAVFCHAYFA------ -------- >Bos_taurus_SLC5A1 -------------------------------------------------------------------------------- ----------------MDSSTWSPPATATAEPLPPYERIRNAADISVIVIYFVVVMAVG--LWAMFSTNRG--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIATGGFEWN------------------ --------ALILVVVLGWVFVPIYIKAG-VVTMPEY---LRKRFGGQRIQVYLSVLSLVLY---IFTKISADIFSG---A IFINLALGLDLYLAIFILLAITALYTIT---GGLAA-VIYTDTLQTVIMLLGSFILTGFA--FHEVGGYGAFVTKYMNAI PT---VTSYGN---TTIKAECYT------PRADSFHIFRDPLKGDLPWPGLIFG-LTIISLWY--WCTD-QVIVQRCLSA KNMSHVKAGCIMCGYL--KLLPMFLMVMPGMISRILFT----------------EKVACTVPSECEKYCG-TKVGCTNIA YPTLVVELM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY TKIRKKAS-------------EKELMIAGRLFMLVLIGVSIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFC KRVNEP---GAFWGLI-IGFLIGVSRMITEFAYGTGSC------------------------------------------ ---MEPSNCPTIICGVHYLYFAIILFVITIIVILAVSLFTKPIADVHLYR-----LCWSLRNSKEER-----IDLDA--- -------------------------------------------------------------EDEDVQDAREDALEIDTEA SEEKKGCFRRAYDMFCGLDQQKAPKMTK----EEEAAMKLKMTDTSENRLWRMVVNINGIILLAVAVFCHAYFA------ -------- >Monodelphis_domestica_SLC5A1 -------------------------------------------------------------------------------- ----------------MDVSASTIARSGTPAAILSSDRFKNAADILVIILYFVVVLAVG--LWAMFSTNRG--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIATGGFEWN------------------ --------ALVLVVVLGWVFVPIYIKAG-VVTMPEY---LRKRFGGKRIQIYLSVLSLLLY---IFTKISADIFSG---A IFINLALGLDLYLAIFLLLAITGLYTIT---GGLAA-VIYTDTLQTAIMLVGSLILTGFA--FNEVGGYEAFMDKYMKSI PS---KISEGN---FTAKPECYT------PRADSFHLFRDPITGDLPWPGLIFG-LGILALWY--WCTD-QVIVQRCLSA KNMSHVKAGCIMCGYL--KLLPMFLMVMPGMISRILYT----------------DKVACAVPSECEAQCG-TKVGCSNIA YPTLVVELM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY TKCRKKAS-------------EKELMIAGRVFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFC KRVNEP---GAFWGLI-FGLLIGLSRMIAEFAYGTGSC------------------------------------------ ---MEPSNCPKIICGVHYLYFAIILFAVSVITILIISLLTKPIPDVHLYR-----LCWSLRNSKEER-----IDLDAD-- -------------------------------------------------------------EEKDFSDSSEEKLEIE--I PPEDKGCCRKAYDMFCGLDQQKGPKMTK----EEEAALKMKMTDTSEKPLWRNIVNINGIILLAVAVFCHAYFA------ -------- >Gallus_gallus_SLC5A1 -------------------------------------------------------------------------------- ----------------MES---------------TAIRINNAADISVIVIYFVVVLAVG--VWAMYSTNRG--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTAAAGGIAIGGYEWN------------------ --------ALIFVVVLGWVFVPIYIKAG-VVTMPEY---LRKRFGGKRIQVYLSILSLILY---IFTKISADIFSG---A VFIQLAMGLNLYLAIIILLAITALYTIT---GGLAA-VIYTDTLQTFIMVVGSFILMGFA--FREVGGYDAFMEKYMNAV PS---NITYGN---STIDSKCYT------PRADSFHIFRDAVTGDLPWPGLTIG-LSILTLWY--WCTD-QVIVQRCLSG KNMSHVKAGCVMCGYL--KLLPMFIIVMPGMISRILYT----------------DVVACAVPEICQQACG-TTVGCTNIA YPKMVVELM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY TKVRKQPS-------------EKELMLAGRAFMVVLIGISIAWVPVVQSAQSGQLFDYIQSVTSYLGPPIAAVFLLAIFC KRVNEQ---GAFWGLV-VGLLAGLGRMISEFAYGTGSC------------------------------------------ ---VAPSNCPFIICGIHYLYFAIILFGISAIVILAVSFMTKPIPDVHLYR-----LCWSLRNSKEER-----IDLDAD-- -------------------------------------------------------------DEEEKPDERDK--ESVSEE S-EDPGCLKKAYNWFCGLDQQKGPKLSK----EEEEALKKKLTDTSEVPLWRNVVNINGIILLTVAVFCHAFFA------ -------- >Taeniopygia_guttata_SLC5A1 -------------------------------------------------------------------------------- ------------------------------------IRINNAADISVIVAYFLVVFHFAFPLPAMYSTNRG--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTAAAGGIAIGGYEWN------------------ --------ALIFVVVLGWIFVPIYIKAG-VVTMPEY---LRKRFGGKRIQVYLSVLSLIIY---VFTKISADIFSG---A VFIQLAIGLNLYLAIIILLSITALYTIT---GGLAA-VIYTDTLQTFIMVLGSFILMGFA--FAEVGGYEAFMQKYMAAI PS---NVSYGG---MEVDPACYT------PRRDAFHIFRDASSGDLPWPGLVFG-LSILAMWY--WCTD-QVIVQRCLSG KNMSHVKAGCIMCGYL--KLLPMFIIVMPGMISRILYT----------------DVVACVVPEVCQRYCG-TAVGCTNIA YPKMVVELM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY TKIRKRPS-------------EKELMLAGRAFMLLLIGISIAWVPVVQSAQSGQLFDYIQSVTSYLGPPIAAVFLLGIFC KRVNEQ---GAFWGVI-IGLLAGLSRMIAEFAYGTGSC------------------------------------------ ---VAHSNCPFIICGIHYLYFALILFGVSAIIILAVSFMTKPIPDVHLYR-----LCWSLRHSKEER-----IDLDAD-- -------------------------------------------------------------EEQDRADEKDN--ESVNEE NQEDPGCCRKAYNWFCGLDQQKGPKLSK----EEEEALKKKLTDTSEVPLWRNVVNINGIILLTVAVFCHAYFA------ -------- >Anolis_carolinensis_SLC5A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------FVEKYMKAV P----TLTAAT---VNISEKCYT------PRPDAFSLFRDPLSGDLPWPGLIFG-LSILALWY--WCTD-QVIVQRCLSA KNMSHVKAGCILCGYM--KLLPMFLMVMPGMISRILYT----------------DQVACIDPDVCLEVCE-TTVGCSNIA YPLMVVKLM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY TKIRTRAK-------------ERELMIVGRVFIVILIGLSILWVPVVQEAQSGQLFDYIQSITSYLGPPIAAVFFLAIFC KRVNET---GAFWGLV-LGLLIGLSRMITEFAFGTGSC------------------------------------------ ---AHPSNCPAIICKVHYLYFAMILFAISIVIVLGASFLTKPIDDVHLYR-----LCWSLRNRTEER-----IDLDA--- --------------------------------------------------------------EEDVAKKEEMVYEDQT-L PERELSCGRKALNWFCGLD-QGGPRLSP----AEEEALRQKMADTTEDPFWKRVVNINAILLLAVAIFCHGFFA------ -------- >Danio_rerio_SLC5A1_a ---------------------------------------------------------------------------MHAQC LEHRGTHLPSSNTVRMGADYFGFSLLRNDVKR-NTTIYVNNPADISVIVIYFLVVLAVG--VWAMVRTNRA--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWN------------------ --------ALVVVIILGWLFVPIYIKAG-VVTMPEY---LKKRFGGQRIRIYLSVLSLCLY---VFTKISADMFAG---A IFINQALGLNIYLAVVILLLITALYTVT---GGLAA-VIYTDTLQTIIMVVGSFILMGFA--FNKVGGYENFRDSYMTAI P------SVIG---TNISESCYT------PRADSFHIFRDPINGDLPWPGLLFG-LTIQAGWY--WCTD-QVIVQRCLSA KNLSHVKAGCILCGYL--KLLPMFLMVFPGMISRVLYP----------------DEIACVDPDECKAVCG-AEVGCTNIA YPKLVVDLM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY TKIRPKAK-------------EKELMIAGRLFMLLLIGISIAWIPIVQTAQSGQLFDYIQSITSYLAPPIAAVFALAIFC KRVNEP---GAFYGLC-VGLLVGLARMITEFAYGTGSC------------------------------------------ ---VNPSNCPTIICGVHYLYFALILFGLSCILILSISLMTKPIEDKHLYR-----LCWSLRNNTEER-----IDLEA--- ---------------------------------------------------------------DDWTEDQ-DSNSMETDE MREEPGCCKKAYNWFCGFDQGNAPKLTK----EQEAELKMKLTDTTEKPLWRNVVNANAVILLTVCVFFHGFFG------ -------- >Tetraodon_nigroviridis_SLC5A1_a -------------------------------------------------------------------------------- ------------PSTMTWEYRGFSSVK-AVENDDDRHKINNPADISVIVVYFVVVLGVG--IWAMVRTNRG--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGVAGTAAASGLAIGGFEWN------------------ --------ALIVVVFLGWLFVPIYIKAG-VVTMPEY---LTKRFGGQRIRIYLSVLSLFLY---VVTKISADMFSG---A IFINQALGLNIYLAVIALLLITALYTVT---GGLAA-VIYTDTLQTIIMIVGSFILMGFA--FGEMGSFEIFQSRYMAAI P------SNN----TGFLPECYK------PRSDSFHLFRDAITGDLPWPGLIFG-LTIQAVWY--WCTD-QVIVQRCLSA KNLSHVKAGCILCGYL--KLLPMFLMVFPGMISRILYT----------------DKVACVHPAECERFCG-TAVGCTNIA YPKLVVDLM---PNGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTMDIY AKIRKRAS-------------EKELMIAGRVFILVLIGVSIAWIPIVQSAQSGQLFDYIQSITSYLTPPIAAVFVLAIFC KRVNEA---GAFYGLM-IGLAIGLSRMITEFVYGTGSC------------------------------------------ ---VSPSNCPTIICGVHYLYFSIILFTISCIVILGISLLTSPIDDQHLYR-----LVWSLRN-KRER-----VDLEQ--- ---------------------------------------------------------------DIWVNDQQDSNSLEIDE PSEPPGLCKRLVMGFCGLEQNQAVKLTK----EEEAELQRKLTDTTEKPLWRNVVNVNALILLAVAFFCHGFFA------ -------- >Gasterosteus_aculeatus_SLC5A1_b -------------------------------------------------------------------------------- ---------------MAQDYLGFSLTRNNARNSNGTVVLNNAADISVIVIYFLVVLAVG--VWAMVRTNRS--------- -----------TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTAAAGGIAIGGFEWN------------------ --------ALVVVIILAWLFVPIYIKAG-VVTMPEY---LKKRFGGQRIRIYLSVLSLFLY---VFTKISADMFSG---A IFINQALGLNIYLAVVMLLLITALYTVT---GGLAA-VIYTDTLQTIIMVIGSFILMGFA--FNEVGGYEQFQQRYMEAI P------ADR----VNVSASCYE------PREDSFHIFRNAITGDLPWPGLIFG-LTIQATWY--WCTD-QVIVQRCLSA KNLSHVKAGCILCGYL--KLLPMFLMVFPGMISRILYP----------------DEVACVDPIKCQEFCD-ASVGCTNIA YPKLVVDLM---PNGLRGLMLSVMMASLMSS--------------------------------LTSIFNSASTLFTMDIY TKIRSRAS-------------ERELMIAGRLFILALIGVSIAWIPVVQSAQSGQLFDYIQSITSYLTPPVAAVFILAIFC KRVNES---GAFYGLV-IGLLIGLSRMITEFIYGTGSC------------------------------------------ ---ISPSNCPTIICGVHYLYFSIILFVVSCIIIVGISLMTKPIEDKHLYR-----LCWSLRNRTEER-----VDIEQ--- ---------------------------------------------------------------DDWIDNQ-ESNDMEIEE HVEEPGLCKKAVMCFCGLDQEKAPTLSP----EEQAELQKKLTDTSEVPLWRNVVNANAIILLCVAVFLHGFFG------ -------- >Homo_sapiens_SLC5A2 -------------------------------------------------------------------------------- -------------------MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVG--LWSMCRTNRG--------- -----------TVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWN------------------ --------ALFVVLLLGWLFAPVYLTAG-VITMPQY---LRKRFGGRRIRLYLSVLSLFLY---IFTKISVDMFSG---A VFIQQALGWNIYASVIALLGITMIYTVTG---GLAA-LMYTDTVQTFVILGGACILMGYA--FHEVGGYSGLFDKYLGAA TS---LTVSEDPAVGNISSFCYR------PRPDSYHLLRHPVTGDLPWPALLLG-LTIVSGWY--WCSD-QVIVQRCLAG KSLTHIKAGCILCGYL--KLTPMFLMVMPGMISRILYP----------------DEVACVVPEVCRRVCG-TEVGCSNIA YPRLVVKLM---PNGLRGLMLAVMLAALMSS--------------------------------LASIFNSSSTLFTMDIY TRLRPRAG-------------DRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFV PRVNEQ---GAFWGLI-GGLLMGLARLIPEFSFGSGSC------------------------------------------ ---VQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHR-----LVFSLRHSKEERED---LDADE--- --------------------------------------------------------QQG-SSLPVQNGCPESAMEMNEPQ APAPS-LFRQCLLWFCGMSRGGVGSPPPL-TQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA------ -------- >Mus_musculus_SLC5A2 -------------------------------------------------------------------------------- -------------------MEQHVEAG--SELGEQKVLIDNPADILVIAAYFLLVIGVG--LWSMFRTNRG--------- -----------TVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWN------------------ --------ALFVVLLLGWLFVPVYLTAG-VITMPQY---LRKRFGGHRIRLYLSVLSLFLY---IFTKISVDMFSG---A VFIQQALGWNIYASVIALLGITMIYTVTG---GLAA-LMYTDTVQTFVILAGAFILTGYA--FHEVGGYSGLFDKYLGAM TS---LTVSKDPSVGNISSTCYQ------PRPDSYHLLRDPVTGDLPWPALLLG-LTIVSGWY--WCSD-QVIVQRCLAG KNLTHIKAGCILCGYL--KLMPMFLMVMPGMISRILYP----------------DEVACVVPEVCKRVCG-TEVGCSNIA YPRLVVKLM---PNGLRGLMLAVMLAALMSS--------------------------------LASIFNSSSTLFTMDIY TRLRPRAG-------------DKELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFV PRVNEK---GAFWGLV-GGLLMGLARLIPEFFFGSGSC------------------------------------------ ---VRPSACPALFCRVHYLYFAIILFICSGILTLGISLCTAPIPQKHLHR-----LVFSLRHSKEERED---LDADE--- --------------------------------------------------------LEGPAPAPVQNGGQECAMEMEEVQ SPAPG-LLRRCLLWFCGMSKSGSGSPPP--TTEEVAATTRRLEDISEDPRWARVVNLNALLMMTVAVFLWGFYA------ -------- >Pan_troglodytes_SLC5A2 -------------------------------------------------------------------------------- -------------------MEEHTEAGSAPELGAQKALIDNPADILVIAAYFLLVIGVG--LWSMCRTNRG--------- -----------TVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWN------------------ --------ALFVVLLLGWLFAPVYLTAG-VITMPQY---LRKRFGGRRIRLYLSVLSLFLY---IFTKISVDMFSG---A VFIQQALGWNIYASVIALLGITMIYTVTG---GLAA-LMYTDTVQTFVILGGACILMGYA--FHEVGGYSGLFDKYLGAA TS---LTVSEDPAVGNISSFCYR------PRPDSYHLLRHPVTGDLPWPALLLG-LTIVSGWY--WCSD-QVIVQRCLAG KSLTHIKAGCILCGYX--KLTPMFLMVMPGMISRILYP----------------DEVACVVPEVCRRVCG-TEVGCSNIA YPRLVVKLM---PNGLRGLMLAVMLAALMSS--------------------------------LASIFNSSSTLFTMDIY TRLRPRAG-------------DRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFV PRVNEQ---GAFWGLI-GGLLMGLARLIPEFSFGSGSC------------------------------------------ ---VQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHR-----LVFSLRHSKEERED---LDADE--- --------------------------------------------------------QQG-SSFPVQNGCPESAMETNEPQ ALAPS-LFRQCLLWFCGMSRGGVGSPPPL-TQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA------ -------- >Gorilla_gorilla_SLC5A2 -------------------------------------------------------------------------------- -------------------MEEHTEAGSAPELGAQKALIDNPADILVIAAYFLLVIGVG--LWSMCRTNRG--------- -----------TVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWN------------------ --------ALFVVLLLGWLFAPVYLTAG-VITMPQY---LRKRFGGRRIRLYLSVLSLFLY---IFTKISVDMFSG---A VFIQQALGWNIYASVIALLGITMIYTVTG---GLAA-LMYTDTVQTFVILGGACILMGYA--FHEVGGYSGLFDKYLGAA TS---LTVSEDPAVGNISSFCYR------PRPDSYHLLRHPVTGDLPWPALLLG-LTIVSGWY--WCSD-QVIVQRCLAG KSLTHIKAGCILCGYL--KLTPMFLMVMPGMISRILYP----------------DEVACVVPEVCRRVCG-TEVGCSNIA YPRLVVKLM---PNGLRGLMLAVMLAALMSS--------------------------------LASIFNSSSTLFTMDIY TRLRPRAG-------------DRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFV PRVNEQ---GAFWGLI-GGLLMGLARLIPEFSFGSGSC------------------------------------------ ---VQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHR-----LVFSLRHSKEERED---LDADE--- --------------------------------------------------------QEG-SSLPVQNGCPERAMEMNEPQ APAPS-LFRQCLLWFCGMSRGGVGSPPPL-TQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA------ -------- >Bos_taurus_SLC5A2 -------------------------------------------------------------------------------- -------------------MEEHTEAGSAPVLGEQKALIDNPADILVIAAYFLLVIGVG--LWSMCRTNRG--------- -----------TVGGYFLAGRNMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWN------------------ --------ALFVVLLLGWLFVPVYLTAG-VITMPQY---LRKRFGGHRIRLYLSVLSLFLY---IFTKISVDMFSG---A VFIQQALGWNIYASVIALLGITMIYTVTG---GLAA-LMYTDTVQTFVILAGAFVLMGYA--FHEVGGYSGLFDKYLRAV TS---LTVSEDPAVGNISSSCYR------PRPDSYHLLRDPVTGDLPWPALLLG-LTIVSSWY--WCSD-QVIVQRCLAG KNLTHIKAGCILCGYL--KLMPMFLMVMPGMISRVLYP----------------DEVACVVPEVCKRVCG-TEVGCSNIA YPRLVVKLM---PNGLRGLMLAVMLAALMSS--------------------------------LASIFNSSSTLFTMDIY TRLRPRAG-------------DRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFV PRVNEK---GAFWGLI-GGLLMGLARLVPEFSFGSGSC------------------------------------------ ---VRPSGCPALLCRVHYLYFAILLFVCSGLLTLVVSLCTPPIPRKHLYR-----LVFSLRHSKEERED---LDAEE--- --------------------------------------------------------LEGPTAAPVQNGRPEHAVEMEAPP PPRPG-LLRQCLLWFCGVSRGGVGSPQRP-TQEETTAAARRLEDISEDPRWARVVNLNALLMMAVATFLWGFYA------ -------- >Monodelphis_domestica_SLC5A2 -------------------------------------------------------------------------------- -------------------MEES--------MADSRNFIDNPADIVVIAGYFFLVIGVG--LWSMCRTNRG--------- -----------TIGGYFLAGRSMIWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWN------------------ --------ALFVVLLLGWLFAPVYLTAG-VITMPQY---LRKRFGGHRIRLYLTVLSLFLY---IFTKISVDMFSG---A VFIQQALGWNIYASVIALLGITMIYTVTG---GLAA-LMYTDTVQTFVILGGAFILMGYA--FNEVGGYTGLFNKYLEAK TT---QTFSEDPMVGNISPSCYE------PRADSYHLLRDPVSGDLPWPALLVG-LTIVSGWY--WCSD-QVIVQRCLAG KNLTHIKAGCILCGYL--KLLPMFLMVMPGMISRILYP----------------DKVACVAPEVCKQICG-TEVGCSNIA YPLLVVKLM---PNGLRGLMLAVMLAALMSS--------------------------------LASIFNSSSTLFTMDIY TRLRPRAG-------------DRELLLVGRLWVLFIVAVSIAWLPVVQAAQGGQLFDYIQAISSYLAPPVSAVFVLALFV PRVNEP---GAFWGLI-GGLLMGLARLIPEFYFGTGSC------------------------------------------ ---VRPSSCPSLFCGVHYLYFAIILFICSCIIILTISFCTTPIPSKHLHR-----LVFSLRHSKEERED---LDVDER-- --------------------------------------------------------QTGPPEFPVQNGQLEHAVEIEEPS RAAPS-LLRQCLLWFCGMTGSGPSSSTP---PSEEATRAQELADITEDPHWARIVNFNALLMMTVAVFLWGFFA------ -------- >Danio_rerio_SLC5A2_a -------------------------------------------------------------------------------- -------------------MEN------TTAKHVTIN---NAADISVIIIYFLVVIAVG--IWSTFRTNRG--------- -----------TVGGYFLAGRTMVWWPVGTSLFASNIGSGHFVGLAGTAAASGIAVGGFEWN------------------ --------ALFIVLLLGWVFVPVYLTAG-VITMPQY---LKKRFGGSRISLYLSIISLFLY---IFTKISVDMFSG---A VFIQQALGWNIYVAVIALLCITALYTVTG---GLAA-LMYTDTVQTFVIIAGAFVLMGFS--FYEVGGYSALLEKYNSSL PS---QTLSLNPNEYNISQHCYM------PREDAFHLLRDPTTGDLPWPGVIFG-IAIIGSWY--WCTD-QVIVQRCLAA RSLTHVKAGCILCGYL--KLLPMFLMVFPGMISRVLYP----------------DDVGCVEKSVCNKVCG-TEVGCSNIA YPKLVVSVM---PTGLRGLMLAVMLAALMSS--------------------------------LASIFNSSSTLFTMDIW TRIRPQAR-------------DKELMVVGRVWILCIVGISICWIPVVQAAQSGQLFDYIQSVTSYLAPPIAAVFFLAIFV KRVNES---GAFWGLM-GGLVMGLCRMVPEFVFGSGSC------------------------------------------ ---LKPSNCPKVICGVHYLYFAILLFFCTAILVLFVSYNTPPIKDKHLHR-----LVFTLRHSTEERVD---LDWEEE-- --------------------------------------------------------ERGRKARREADEKRRAKNDEDQIE RGEQS-IMMKIIGWFCGISDTQAPEPTE----EEVTEASKQLPDISENPLWKNLVNVNALIMMTVAVYFWGFYA------ -------- >Gasterosteus_aculeatus_SLC5A2_a -------------------------------------------------------------------------------- -------------------LESR-----TTPLTPCFSRFCNPADISVIVGYFVAVIGVG--VWAMLRSNRG--------- -----------TVGGYFLAGRTMTWWPVGASLFASNIGSGHFVGLAGTGAASGIAVGGFEWN------------------ --------ALFIVLLLGWLFVPVYLTAG-VITMPQY---LKKRFGGTRISLYLTVISLFLY---IFTKISVDMFSG---A VFIQQALGWNIYVAVITLLLITALYTITGT--DPAA-LMFTDTVQTFVIIAGAFVLTGFS--FAKVGGYSALLAKYSAAT PS---NFSSTEPQRYNISPSCYT------PRQDAFNLLRDPTTGDLPWPGVLFG-IAIVGGWY--WCTD-QVIVQRCLAA RNLTHVKAGCIMCGYL--KLLPMFLMVFPGMISRVLYP----------------DEVGCVVPEVCKRVCG-TEVGCSNIA YPKLVVSIM---PNGLRGLMLAVMLAALMSS--------------------------------LASIFNSSSTLFTLDIW TRIRPQAA-------------ERELLIVGRVWVLIIVCVSICWIPVVQAAQSGQLFDYIQSVSSYLAPPIASVFFLAVFV KRVNEQ---GAFWGLI-A-AVMGLCRMLPRVWFGSGSC------------------------------------------ ---VFPSTCP-LVCGIHYLHFAIILFFCTSVLVLVVSCCSRPIEDEHLHR-----LVFSLRHSKEERVD---LDWEQE-- --------------------------------------------------------EKGRRARREAEERRRESKDSG-KE QMKTA-AEASCVGRLCGSSQAHEEAP--------PPEAPEKLPDIGEEPAWRHVVDANALIMMAAAVFMWGYYA------ -------- >Homo_sapiens_SLC5A3 -------------------------------------------------------------------------------- -----------------------------------MRAVLDTADIAIVALYFILVMCIG--FFAMWKSNRS--------- -----------TVSGYFLAGRSMTWVTIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFN------------------ --------ALLLLQLLGWVFIPIYIRSG-VYTMPEY---LSKRFGGHRIQVYFAALSLILY---IFTKLSVDLYSG---A LFIQESLGWNLYVSVILLIGMTALLTVTG---GLVA-VIYTDTLQALLMIIGALTLMIIS--IMEIGGFEEVKRRYMLAS PDVT-SILLTY--NLSNTNSCN-----VSPKKEALKMLRNPTDEDVPWPGFILG-QTPASVWY--WCAD-QVIVQRVLAA KNIAHAKGSTLMAGFL--KLLPMFIIVVPGMISRILFT----------------DDIACINPEHCMLVCG-SRAGCSNIA YPRLVMKLV---PVGLRGLMMAVMIAALMSD--------------------------------LDSIFNSASTIFTLDVY KLIRKSAS-------------SRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFW KRCNEQ---GAFYGGM-AGFVLGAVRLILAFAYRAPEC------------------------------------------ ---DQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQIRT-----TTFWSKKNLVVKENCSPKEEPYQMQ EKSILRCSENNETINHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKE- -TDDGGRYWKFIDWFCGFKSKSLSKRSLRD-LMEEEA--VCLQMLEETRQVKVILNIGLFAVCSLGIFMFVYFSL----- -------- >Mus_musculus_SLC5A3 -------------------------------------------------------------------------------- -----------------------------------MRAVLEAADIAVVALYFILVMCIG--FFAMWKSNRS--------- -----------TVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFN------------------ --------ALLLLQLLGWVFIPIYIRSG-VYTMPEY---LSKRFGGHRIQVYFAALSLLLY---IFTKLSVDLYSG---A LFIQESLGWNLYVSVILLIGMTALLTVTG---GLVA-VIYTDTLQALLMIIGALTLMVIS--MVKIGGFEEVKRRYMLAS PDVA-SILLKY--NLSNTNACM-----VHPKANALKMLRDPTDEDVPWPGFILG-QTPASVWY--WCAD-QVIVQRVLAA KNIAHAKGSTLMAGFL--KLLPMFIIVVPGMISRIVFA----------------DEIACINPEHCMQVCG-SRAGCSNIA YPRLVMTLV---PVGLRGLMMAVMIAALMSD--------------------------------LDSIFNSASTIFTLDVY KLIRKSAS-------------SRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFW KRCNEQ---GAFYGGM-AGFVLGAVRLILAFTYRAPEC------------------------------------------ ---DQPDNRPGFIKDIHYMYVATALFWITGLITVIVSLLTPPPTKDQIRT-----TTFWSKKTLVTKESCSQKDEPYKMQ EKSILQCSENSEVISHTIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASMGHSEAETPVDAYSNGQAALMGEREREKE- -TENRSRYWKFIDWFCGFKSKSLSKRSLRD-LMDEEA--VCLQMLEETPQVKVILNIGLFAVCSLGIFMFVYFSL----- -------- >Gorilla_gorilla_SLC5A3 -------------------------------------------------------------------------------- ---------------------------------TRMRAVLDTADIAIVALYFILVMCIG--FFAMWKSNRS--------- -----------TVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFN------------------ --------ALLLLQLLGWVFIPIYIRSG-VYTMPEY---LSKRFGGHRIQVYFAALSLILY---IFTKLSVDLYSG---A LFIQESLGWNLYVSVILLIGMTALLTVTG---GLVA-VIYTDTLQALLMIIGALTLMIIS--IMEIGGFEEVKRRYMLAS PDVT-SILLTY--NLSNTNSCN-----VSPKKEALKMLRNPTDEDVPWPGFILG-QTPASVWY--WCAD-QVIVQRVLAA KNIAHAKGSTLMAGFL--KLLPMFIIVVPGMISR-----------------------------------------CSNIA YPRLVMKLV---PVGLRGLMMAVMIAALMSD--------------------------------LDSIFNSASTIFTLDVY KLIRKSAS-------------SRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFW KRCNEQ---GAFYGGM-AGFVLGAVRLILAFAYRAPEC------------------------------------------ ---DQPDNRPGFIKDIHYMYVATGLFWVTGLITV---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Gallus_gallus_SLC5A3 -------------------------------------------------------------------------------- -----------------------------------MRASLETADIAIVALYFVLVMCIG--FFAMWKYNRS--------- -----------TVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFN------------------ --------ALMLLQLLGWVFVPVYIRSG-VYTMPEY---LSKRFGGHRIQIYFAALSLILY---IFTKLSVDLYSG---A LFIQESLGWNLYLSVILLIGMTALLTVTG---GLVA-VIYTDTLQALLMIIGALTLMIIS--IMEVGGFEEVKRRYMLAS PNIT-SILLTY--NISNTNSCN-----VDPKPDALKMLREPADEDIPWPGFLLG-QTPASVWY--WCAD-QVIVQRVLAA KNIAHAKGSTLMAGFL--KLLPMFIIVVPGMISRILFA----------------DDIACINPEHCFQVCG-SRAGCSNIA YPRLVMKLV---PVGLRGLMMAVMIAALMSD--------------------------------LDSIFNSASTIFTLDVY KLIRKSAT-------------SRELMIVGRVFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLMGIFW KRCNEQ---GAFYGGM-AGFILGAIRLILAFIYRAPEC------------------------------------------ ---NQPDTRPSFIKSIHYMYVATALFWITGIVTFIVSLLTPPPTKEQVRT-----TTFWAVRNRNVKENTA-KGERYKIQ EKNILRCNEN---ANHIIPNGKSEENIKNIKPEDINLLVTCRDDSNPVISVSHSEVETPVDCYSNGQAALMGEKKHEEE- -TDDRERHLKFIDWFCGFKSKNMNKRAVR--EMEEET--VCLQMLEETPKVKLLLNTGLVCVCSLGIFMFVYFSL----- -------- >Taeniopygia_guttata_SLC5A3 -------------------------------------------------------------------------------- -----------------------------------MRASLEPADIAIVALYFVLVMCIG--FFAMWKNNRS--------- -----------TVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFN------------------ --------ALMLLQLLGWVFVPVYIRSG-VYTMPEY---LSKRFGGHRIQIYFAALSLLLY---IFTKLSVDLYSG---A LFIQESLGWNLYLSVILLIGMTALLTVTG---GLVAAMIYRDIIQPLHMITGALTLMIIS--LMEVGGFEEVKRRYMLAS PNIT-SILLTY--NISNTNSCN-----VSPKPDSLKMLREPTDEDIPWPGFLLG-QTPASVWY--WCAD-QVIVQRVLAA KNIAHAKGSTLMAGFL--KLLPMFIIVVPGMISRILFV----------------DDIACINPEHCFQVCG-SRAGCSNIA YPRLVMNLV---PVGLRGLMMAVMIAALMSD--------------------------------LDSIFNSASTIFTLDVY KLIRKSAT-------------SRELMIVGRVFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLMAIFW KRCNEQ---GAFYGGM-AGFVLGAIRLILAFFYRAPEC------------------------------------------ ---DQPDTRPDFIKNIHYMYVATALFWITGAVTVVVSLLTPPPTKEQVRT-----TTFWALWKRGAPESAG-KGELYQAQ EKSILKCNEN---ANHIIPNGKSEENIKNVKPEDINLLVTCRDDSNPVISVSHSEVETPVDCYSNGQAALMGEKKHEEEE GTDNRARHLKFIDWFCGFKSKNVNKRVVR--EVEEET--VCLQMLEETPKVKLLLNTGLVCVCSLGIFMFVYFSL----- -------- >Danio_rerio_SLC5A3_a -------------------------------------------------------------------------------- --------------------------------MLKTGPAMEAADITVVALYFVLVLVIG--LLAMWKANHS--------- -----------TVSGYFLAGRTMNWAVIGASLFVSNIGSEHFIGLAGSGAASGFAVAAWEFN------------------ --------ALLLLQLLGWVFIPVYIHSG-VYTMPEY---LSKRYGGKRLKIYFAGLSLLLY---IFTKLSVDLYAG---A LFIQESLGWNLYLSIILLISMTALLTVTG---GLVA-VIYTDTLQAVLMIGGALTLTIIS--LIKVGGLEGVREKYMEAV PNVT-AILASSNFSFEYTNSCR-----IYPKPDSLKLLRGPLDEDIPWPGFLLG-QTPSSIWY--WCAD-QVIVQRVLAA KNIAHAKGSTLMAGVL--KILPMFIIVIPGMISRILFP----------------DELACIGPEHCMAVCG-SQAGCSNIA YPRLVMSVM---PVGLRGLMMAVMIAALMSD--------------------------------LDSIFNSASTIFTLDIY KMLRARAS-------------SRELVVIGRIFVIFMVAISIAWVPVIIEMQGGQMYLYIQEVAGYLTPPIAALFLLGVFW KRCNEI---GAFCGGM-TGFVLGTTRLLLGFIYREPKC------------------------------------------ ---DQPDERPAFITRIHYMYIAAGLFWISGLVAVVVSLCTTPPDEERIKR-----TTMWGLRK-LRRLVVTEREE---MY KLTNGSGNGI---LKKDVPEDVQKE--KCLDGADIKLLLPSPCDQ--DPTTPNTEASTPMELYGNGHAKLVKQKDESQS- -DDES--CLQVIDWICCHKEKTSVV-EPKF-IKEDEE--TIREMLHEPPKIKLLLNICLVLICLLGIFMFVYFSL----- -------- >Tetraodon_nigroviridis_SLC5A3_a -------------------------------------------------------------------------------- -----------------------------------MGPGMEAADIAVVALYFILVVVIG--FLAMWKANRS--------- -----------TVSGYFLAGRSMTWIVIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFN------------------ --------ALLLLQLLGWVFVPVYIHSG-VYTMPEY---LSKRYGGNRLKVYFAFLSVMLY---IFTKLSVDLYAG---A LFIQESLGWNLYLSILLLISLTALLTVTG---GLVA-VMYTDALQAVLMIGGALTLTVMS--LIQVGGLEGVRTRYMKAV PNVP-AIIASG--NFTYSPTCR-----IHPKEHSLRILRGPLDEDIPWPGFILG-QTPASIWY--WCAD-QVIVQRVLAA KNIAHVKGSTLMAGFL--KVLPMFLIVIPGMISRIMFA----------------DEIACIGPEHCMAVCG-SQAGCSNIA YPRLVMAVM---PVGLRGLMMAVMLAALMSD--------------------------------LDSIFNSASTIFTLDIY QTVRRKAS-------------QRELLIIGRVFVVVMVAISIAWVPVIIEMQGGQTYLYIQEVAGYLTPPIAALFLLGVFW KRCNEK---GAFWGGM-TGFILGTLRLILAFIYRQPRC------------------------------------------ ---DQPDDRPAFIVKVHYMYFAAGLFWLSGLVAVVVSLCTSPPDDEQVHT-----TTIWGLRN-IQKVPARSREEMFTLT EKSPNNHDAN---LHKEMPPDVRNE--RCLDGADVKLLVPSTDHDPATPSTETSPATTPGQHFGNGKMDVIKAEQGYRA- -HEETGRCARVVEWLCGYKEGPQDT-QQKV-PQDDKR--VIAEMLYEPPKVKILLNTVLVLVCILDIFMFVYFSL----- -------- >Gasterosteus_aculeatus_SLC5A3_a -------------------------------------------------------------------------------- -------------------------------------SGMETVDVVVVALYFVLVLAIG--FFAMWKSNRS--------- -----------TVSGYFLAGRSMTWIVVGASLFVSNIGSEHFIGLAGSGAASGYAVGAWEFN------------------ --------ALLLLQLLGWVFVPVYIHSG-VYTMPEY---LSKRFGGNRLKVYFAFLSLLLY---IFTKLSVDLFAG---A LFIQESLGWNLYVSIFLLISMTALLTVTG---GLVA-VLYTDSLQAVLMICGALTLSILS--LLKVGGLEGVRTKYMQAV PNVT-AIMATG--NFTYSPSCR-----IDPKPNALRLLRGPLDEDIPWPGFLLG-QTPASIWY--WCAD-QVIVQRVLAA KNLAHAKGSTLMAGLL--KILPMFLIVIPGMISRIMFV----------------DELACIGPEHCVSVCG-SQAGCSNLA YPRLVMAVM---PVGLRGLMMAVMIAALMSD--------------------------------LDSIFNSASTIFTLDIY KTARGEAS-------------QRELLIMGRLFVVLMVAISIAWVPVIIDMQGGQTYLYIQEVAGYLTPPIAALFLLGVFW KRCNEK---GAFCGAM-TGFALGVTRLMLAFAYRQPRC------------------------------------------ ---DQPDDRPAFIVKIHYMYVATGLFWITGLVVVVVSLCTPPPDEEQVRT-----TTFWGVRN-MKTLPVDEK------- -KSHCGADGS---LEEEMP----------LN----------------TPSTETSPVTTPPERFDSAKMEMIRKES-CHD- -TGETSRFVRLLECFCGCKEEAQSP-KRNV-LQEDAR--VIAERLYEPPQIKALLNMGLLINCCLAISMYVYFS------ -------- >Ciona_intestinalis_SLC5A3 -------------------------------------------------------------------------------- --------------------------------MTELSNQLNTADLSVVVVYFLLILIIG--VVASCLSRRD--------- -----------TVQGYFLAGRNMNFFLVGASLFVSNIGSEHFIGLAGSGASGGIGVGAWELN------------------ --------ALMLLQLLGWVFIPVYIASG-ICTMPEY---LERRFGGKRLRIYLATLTLILY---CLTKISVNLYSG---A LFIQQSMGWHLYSSVTLLVCLTALLTVTG---GLTV-VMYTDSLQAVLMIGGALYLTIQG--FIYTNGYYGMKEKYMMAS PNIT-YIEDTYNITVNESDSCFP-----KPREDSFTMLKGITDDEMPWLGFLLG-QTPSSIWY--WCTD-QVIVQRALAA KSLSHAQGGTLMAGFI--KILPMYIMVMPGMISRVLYK----------------NDIACVPGEHCYQVCG-SESGCSNLA YPKLVLGVM---PSGARGLMMAVMIAALMSD--------------------------------LDSIFNSASTIFTLDLW KRLRKSAS-------------NTELMVVGRLFIVLLVGVSIAWVPIILQFQGGQLFFYIQEVTNYISPPIAAIFLTGILW RGCTEK---GAFYGGL-VGSTLGLARLITIFVYTPPKC------------------------------------------ ---GEIDTRPWFLTKLHYMYYSALLFSTTIIVAVIVSYFTRKSQVQDLAR-----LTYWTR------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Ciona_savignyi_SLC5A3 -------------------------------------------------------------------------------- ---------------------------------------LSVADLSVVLVYFLLILIIG--IAASCFSRRD--------- -----------TVQGYFLAGRNMNFLMIGASLFVSNIGSEHFIGLAGSGASGGIGVGAWELN------------------ --------ALMLLQLLGWIFIPVYIASG-ICTMPEY---LEQRFGGKRLRIYLATLTLVLY---CLTKISVNLYSG---A LFIQQSMGWHLYSSVTLLVCVTALLTVTG---GLTV-VMYTDSLQAVLMVCGAAYLTIQGTRFISVDGYYGMKEKYMQAT PNIT-YIQQKYNISVNSSDECFP-----YPREDSFTMLKGITDDEMPWLGFLLG-QTPSSIWY--WCTD-QVIVQRALAA RSLSHAQGGTLVAGFI--KILPMYIMVMPGMISRVLFT----------------NEIACVPGEHCYQVCE-SESGCSNLA YPKLVLRVM---PSGARGLMMAVMIAALMSD--------------------------------LDSIFNSASTIFTLDLW KRLRKSAT-------------NTELMIVGRLFIILLVGISIAWVPIILQFQGGQLFFYIQEVTNYISPPIAAIFLTAILW KGCTEK---GAFYGGL-VGSSLGLARLITIFIFKPPKC------------------------------------------ ---GEEDTRPSFLSSMHYMYFSAILFFLTICIAVLVSLFTKKSAAENLAH-----LTYWTRNDSYTAADCELKLMKSDNH MKSKKAKSDI-------------------------------------------------QEESHEDDVSIVQETTEKCG- ---LKSCFYKSVRFVCGIRNPADSN-------ESSDE--VHFPSVAQNPRVKILLHIALLCILGCGVFMYIFWS------ -------- >Branchiostoma_floridae_SLC5A3 -------------------------------------------------------------------------------- ---------------------------MAVETLDDLDTRLGAGDIVAVIVYFVAVVCVG--LWAMRRSNRG--------- -----------TVSGFFLAGRTMIWLPVGASLFVSNIGSEHFIGLAGSGAAGGIGVGAWEFN------------------ --------ALMLLQLLGWIFVPVYIACG-TTTMPQW---LRKRFGGQRLRVMFAVLSLVLY---VMIKLSVNLYSG---A LFIEQSLGWNMYLSIAILLILTAIVTITG---GLAA-VIYTDTLQAVLMVLGAVALMIVS--MIRVGGWGGLREQFMQAM PNITKEYIHAQQFNLTMNNYTEQYGKCGIPSDDSFVMLREINDPQMPWLGFLLG-QTPASIWY--WCTD-QVIVQRALAA KNLDHARGATLMAGFI--KILPMFMMVVPGMVSRILFP----------------NQVGCADPATCLEVCG-NSHGCTNIA YPKLVLGVM---PVGARGIMMAVMVAALMSD--------------------------------LDSIYNSASTIFTIDIW QRLRPHAG-------------NRELMIVGRVIMLILTVVSILWVPILMASSGAQLFIYIQEICDYLVPAIAAIFLVGVFW KRCNEM---GAFWGLM-GGVVIGLVRTILVFLYEDVRCG----------------------------------------- ---DHVEVAPPGIVSLHYMYYALIIFVSTIILTVVISLLTQP-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Homo_sapiens_SLC5A4 -------------------------------------------------------------------------------- ----------------MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVG--LWAMLKTNRG--------- -----------TIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT------------------ --------SSVMLLILGWIFVPIYIKSG-VMTMPEY---LKKRFGGERLQVYLSILSLFIC---VVLLISADIFAG---A IFIKLALGLDLYLAIFILLAMTAVYTTT---GGLAS-VIYTDTLQTIIMLIGSFILMGFA--FNEVGGYESFTEKYVNAT PS---VVEGDN---LTISASCYT------PRADSFHIFRDAVTGDIPWPGIIFG-MPITALWY--WCTN-QVIVQRCLCG KDMSHVKAACIMCAYL--KLLPMFLMVMPGMISRILYT----------------DMVACVVPSECVKHCG-VDVGCTNYA YPTMVLELM---PQGLRGLMLSVMLASLMSS--------------------------------LTSIFNSASTLFTIDLY TKMRKQAS-------------EKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFC KRVNEQ---GAFWGLM-VGLAMGLIRMITEFAYGTGSC------------------------------------------ ---LAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYR-----LCWVLRNSTEER-----IDIDA--- --------------------------------------------------------------EEKSQEETDDGVEEDY-- PEKSRGCLKKAYDLFCGLQ--KGPKLTK----EEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA------ -------- >Mus_musculus_SLC5A4 -------------------------------------------------------------------------------- ----------------MASTASVSTSTASSELSSLSNNINNAADISVIVIYFVVVMAVG--VWAMLKTNRS--------- -----------TVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESH------------------ --------SFALLLVLGWIFVPIYIKAG-VMTMPEY---LKKRFGGKRLQIYLSILFLFIC---VILTISADIFSG---A IFIKLALGLNLYLAILILLAITAIFTIT---GGLAS-VIYTDTVQAVIMLVGSFILMVFA--FVEVGGYESFTEKFMNAI PS---VVEGDN---LTINSRCYT------PQPDSFHIFRDPVTGDIPWPGTAFG-MPITALWY--WCIN-QVIVQRCLCG KNLSHVKAACILCGYL--KLLPLFFMVMPGMISRILYT----------------DMVACVVPSECVKHCG-VDVGCTNYA YPMLVLKLM---PMGLRGLMLSVMLASLMSS--------------------------------LTSVFNSASTLFTIDLY TKIRKKAS-------------ERELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFC KRANEQ---GAFWGLM-VGLVMGLIRMIAEFSYGTGSC------------------------------------------ ---LAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHR-----LCWALRNSKEER-----IDLDA--- --------------------------------------------------------------EDKEENGADDRTEEDQ-- TEKPRGCLKKTCDLFCGLQR-AEFKLTK----VEEEA----LTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA------ -------- >Pan_troglodytes_SLC5A4 -------------------------------------------------------------------------------- ----------------MASTVSPSTIAETPEPPPLSDRIRNAADISVIVIYFLVVMAVG--LWAMLKTNRG--------- -----------TIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT------------------ --------SSVMLPILGWIFVPIYIKSG-VMTMPEY---LKKRFGGERLQVYLSILSLFIC---VVLLISADIFAG---A IFIKLALGLDLYLAIFILLAMTAVYTIT---GGLAS-VIYTDTLQTIIMLIGSFILMGFA--FNEVGGYESFTEKYMNAT PS---VVEGDN---LTISASCYT------PRADSFHIFRDAVTGDIPWPGIIFG-MPITALWY--WCTN-QVIVQRCLCG KDMSHVKAACIMCAYL--KLLPMFLMVMPGMISRILYT----------------DMVACVVPSECVKHCG-VDVGCTNYA YPTMVLELM---PQGLRGLMLSVMLASLMSS--------------------------------LTSIFNSTSTLFTIDLY TKMRKQAS-------------EKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFC KRVNEQ---GAFWGLM-VGLAMGLIRMITEFAYGTGSC------------------------------------------ ---LAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYR-----LCWVLRNSTEER-----IDIDA--- --------------------------------------------------------------EEKSQEETDDGVEEDY-- PEKSRGCLKKAYDLFCGLQ--KGPKLTK----EEEEALSKKLTDTSERPLWRTIVNINAILLLAVTVFIHGYYA------ -------- >Gorilla_gorilla_SLC5A4 -------------------------------------------------------------------------------- ----------------MASTVSPSTIAETPEPPPLSDRIRNAADISVIVIYFLAVMAVG--LWALRSSDRS--------- -----------ISASICLFSRSLIWIFMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT------------------ --------SSVMLPILGWIFVPIYIKSG-VMTMPEY---LKKRFGGERLQVYLSILSLFIC---VVLLISADIFAG---A IFIKLALGLDLYLAIFILLAMTAVYTITV--GGLAS-VIYTDTLQTIIMLIGSFILMGFA--FNEVGGYESFTKKYMNAT PS---VVEGDN---LTISASCYT------PRADSFHIFRDPVTGDIPWPGIIFG-MPITALWY--WCTN-QVIVQRCLCG KDMSHVKAACIMCAYL--KLLPMFLMVMPGMISRILYT----------------DMVACVVPSECVKHCG-VDVGCTNYA YPTMVLELM---PQGLRGLMLSVMLASLMSS--------------------------------LTSIFNSTSTLFTIDLY TKMRKQAS-------------EKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFC KRVNEQ---GAFWGLM-VGLAMGLIRMITEFAYGTGSC------------------------------------------ ---LAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYR-----LCWVLRNSTEER-----IDIDA--- --------------------------------------------------------------EEKSQEETDDGVEEDY-- PEKSRGCLKKAYDLFCGLQ--KGPKLTK----EEEEALSKKLTDTSERPLWRTIVNINAILLLAVVVFIHGYYA------ -------- >Bos_taurus_SLC5A4 -------------------------------------------------------------------------------- ----------------MASTLSPSAVTETPSPPETSERIQNAADISVIVIYFVLVMAVG--LWAMLRTNRG--------- -----------TVGGFFLAGRDVTWWPMGASLFASNIGSGHFVGLAGTGAASGIAIAAFEWN------------------ --------ALLLLLVLGWFFVPIYIKAG-VTTMPEY---LRKRFGGKRLQVYLSILSLFIC---VALRISSDIFSG---A IFITLALGLDLYLAIFILLALTAIYTIT---GGLAS-VIYTDTLQTAIMLIGSFILMGFA--FAEVGGYENFTDKYMNAI PT---IVEGDN---LTIKSKCYT------PQGDSFHIFRDAVTGDIPWPGTIFG-MTVVAAWY--WCTD-QVIVQRCLSG KDMSHVKAACIMCGYL--KLLPMFLMVMPGMISRILFT----------------EKVACVVPSECVKHCG-VKVGCSNYA YPMLVMELM---PNGLRGLMMSVMLASLMSS--------------------------------LTSIFNSASALFTIDLY TKIRKRAS-------------EKELLIAGRLFIILLIAISIVWVPLVQVAQNGQLFHYIESISSYLGPPIAAVFLLAIFC KRVNEQ---GAFWGLI-VGFVIGLIRMIAEFVYGTGSC------------------------------------------ ---LAASNCPQVICGVHYLYFALILFFVSILITLGISLLTKPIPDVHLYR-----LCWALRNSTEER-----IDLDT--- --------------------------------------------------------------EEERHEEAHDGVDSDN-- PEETRGCLRKAYDLFCGLQR-KGPKLSE----EEEEARKKKLTDTSEKPLWRTVVNINAIILLAVAVFVHGYFA------ -------- >Homo_sapiens_SLC5A5 -------------------------------------------------------------------------------- -----------MEAVETGERP-----------------TFGAWDYGVFALMLLVSTGIGLWVGLARG-GQRS-------- ------------AEDFFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLL--------------- -----------NSVLTALLFMPVFYRLG-LTSTYEY---LEMRFSRA-VRLCGTLQYIVA----TMLYTGIVIYAP---A LILNQVTGLDIWASLLSTGIICTFYTAVG---GMKA-VVWTDVFQVVVMLS--GFWVVLARGVMLVGG-PRQVLTLAQNH S-----------------------------RINLMDFNPDPRSRYTFWTFVVGG----TLVWLSMYGVN-QAQVQRYVAC RTEKQAKLALLINQVG--LFLIVSSAACCGIVMFVFYTD--------------------CDPLLLGRISAPDQ------Y MPLLVLDIFEDLP-GVPGLFLACAYSGTLST--------------------------------ASTSINAMAAVTVEDLI KPRLRSLAPRKLV-----IISKGLSLIYGSACLTVAALSSLLGGGVLQGS---------FTVMGVISGPLLGAFILGMFL PACN-TP--GVLAGLG-AGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMD ASRP---ALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRST--LAPGLLWWDLARQTASVAPKE-----EVAIL DDNLV--------------------------------------------------------------------------- ------------KGPEELPTGNK-KPPGF---------------LPTNEDRLFFLGQKELEGAGSWTPC-----VGHDGG RDQQETNL >Mus_musculus_SLC5A5 -------------------------------------------------------------------------------- -----------MEGAEAGARA-----------------TFGPWDYGVFATMLLVSTGIGLWVGLARG-GQRS-------- ------------ADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCVGQLL--------------- -----------NSLLTALLFLPIFYRLG-LTSTYQY---LELRFSRA-VRLCGTLQYLVA----TMLYTGIVIYAP---A LILNQVTGLDIWASLLSTGIICTLYTTVG---GMKA-VVWTDVFQVVVMLV--GFWVILARGVMLMGG-PWNVLSLAQNH S-----------------------------RINLMDFDPDPRSRYTFWTFVVGG----SLVWLSMYGVN-QAQVQRYVAC HTERKAKLALLVNQLG--LFLIVASAACCGIVMFVYYKD--------------------CDPLLTGRIAAPDQ------Y MPLLVLDIFEDLP-GVPGLFLACAYSGTLST--------------------------------ASTSINAMAAVTVEDLI KPRMPSLAPRKLV-----FISKGLSFIYGSTCLTVAALSSLLGGGVLQGS---------FTVMGVISGPLLGAFTLGMLL PACN-TP--GVLSGLT-AGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTNASVLPS-----PPGAANTSRGIPSSGMD SGRP---AFADTFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSS--LGPGLLWWDLARQTASVAPKE-----DTTTL EDSLV--------------------------------------------------------------------------- ------------KGPEDIPAATK-KPPGF---------------RPEAETHPLYLGH----------------------- --DAETNL >Pan_troglodytes_SLC5A5 -------------------------------------------------------------------------------- -----------MEAVETGERP-----------------TFGAWDYGVFALMLLVSTGIGLWVGLARG-GQRS-------- ------------AEDFFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLL--------------- -----------NSVLTALLFMPVFYRLG-LTSTYEY---LEMRFSRA-VRLCGTLQYIVA----TMLYTGIVIYAP---A LILNQVTGLDIWASLLSTGIICTFYTAVG---GMKA-VVWTDVFQVVVMLS--GFWVVLARSVMLVGG-PRQVLTLAQNH S-----------------------------RINLMDFNPDPRSRYTFWTFVVGG----TLVWLSMYGVN-QAQVQRYVAC RTEKQAKLALLINQVG--LFLIVSSAACCGIVMFVFYSD--------------------CDPLLLGRISAPDQ------Y MPLLVLDIFEDLP-GVPGLFLACAYSGTLST--------------------------------ASTSINAMAAVTVEDLI KPRLRSLAPRKLV-----IISKGLSLIYGSACLTVAALSSLLGGGVLQGS---------FTVMGVISGPLLGAFILGMFL PACN-TP--GVLAGLG-AGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMD DSRP---ALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRST--LAPGLLWWDLARQTASVAPKE-----EVAIL DDNLV--------------------------------------------------------------------------- ------------KGPEELPAGNK-KPPGF---------------LPTNEDRLFFLGQKELEGAGSWTPC-----VGHDGG RDQQETNL >Gorilla_gorilla_SLC5A5 -------------------------------------------------------------------------------- -----------MEAVETGERP-----------------TFGAWDYGVFALMLLVSTGIGLWVGLARG-GQRS-------- ------------AEDFFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLL--------------- -----------NSVLTVLLFMPVFYRLG-LTSTYEY---LEMRFSRA-VRLCGTLQYIVA----TMLYTGIVIYAP---A LILNQVTGLDIWASLLSTGIICTFYTAVG---GMKA-VVWTDVFQVVVMLS--GFWVVLARGVMLVGG-PRQVLTLAQNH S-----------------------------RINLMDFNPDPRSRYTFWTFVVGG----TLVWLSMYGVN-QAQVQRYVAC RTEKQAKLALLINQVG--LFLIVSSAACCGIVMFVFYTD--------------------CDPLLLGRISAPDQ------Y MPLLVLDIFEDLP-GVPGLFLACAYSGTLST--------------------------------ASTSINAMAAVTVEDLI KPRLRSLAPRKLV-----IISKGLSLIYGSACLTVAALSSLLGGGVLQR-----------PSGDFFAAGWLGAGELGRWG VATERAS--GVLSGLG-AGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRVPSSGMD ASRP---ALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRST--LAPGLLWWDLARQTASVAPKE-----EVAIL DDNLV--------------------------------------------------------------------------- ------------KGPEELPAGNK-KPPGF---------------LPTNEDRLFFLGQKELEGAGSWTPC-----VGHDGG RDQRETNL >Bos_taurus_SLC5A5 -------------------------------------------------------------------------------- -----------MATVEAKERA-----------------TFGAWDYGVFALMLLVSTGIGLWVGVARG-GQRS-------- ------------AEDFFTGGRRLSALPVGLSLAASFMSAVQVLGVPAEAYRYGLKFLWMCLGQLL--------------- -----------NSLLTALLFLPVFYRLG-LTSTYEY---LEMRFSRA-VRLCGTLQYLVA----TMLYTGIVIYAP---A LILNQVTGLDIWASLLSTGIICTFYTTVG---GMKA-VIWTDVFQVLVMLS--GFWVVLARGTALVGG-PGQVLELAKNH S-----------------------------RINLMDFDLDPRSRYTFWTFVVGG----TLVWLSMYGVN-QAQVQRYVAC RTEKQAKLAVLINQLG--LFLIVSSAAACGVVMFTFYLD--------------------CDPLLAGRISAPDQ------Y MPLLVLDIFEDLP-GVPGLFLACAYSGTLST--------------------------------ASTSINAMAAVTVEDLI KPRLPSLAPRRLV-----IISKGLSLIYGSACLTVAALSSLLGGGVLQGS---------FTVMGVISGPLLGAFILGMFV PTCN-TP--GVLSGLA-VGLALSLWVAVGATLYPPSAQSMGVLPSSASGCAVPSANASGLLDP-LLTANASSRVSSLEMD PDQQ---TLADNFYAISYLYYGALGTVCTVLCGALVSCLTGPTKRSA--LGPGLLWWDLMRQTASVAPKE-----EVATL DDGLM--------------------------------------------------------------------------- ------------KGSDMVSHQTQWKPPG-----------------PT-------LGS-EKDPRSSWS------------- --DLSANL >Xenopus_tropicalis_SLC5A5 ------------------------------------------------------------------MDTFCWKYLMSPQF LLNLWAPTQHLQHTSASSHRSPDTEIMEEYVPLVHESLTFSLWDYGVFATMLIMSTGIGLFYAFSHG-GQKT-------- ------------SDDFFTGGRSMSAVPVGLSLSASFMSAVQVLGVPAEAYRYGVKFLQMCIGQIL--------------- -----------NSVMTAYIFMPIFYRLG-ITSTYQY---LEMRFSRS-VRLYGTIQFLLG----TMFYTGIVIYAP---A LILNQVTGLDIWASLFSTGAICTFYTTVG---GMKA-VIWTDVFQVFVMLS--GFFAVAIRGIHLVGG-FSDAIEVAGNY S-----------------------------RINFGDFDPDPRRRYTFWTFVMGS----TFLWLSMYGVN-QAQVQRYVAC KTENEAKLAILVNQVA--LCVIVSSAVTCGIVMFVYYLN--------------------CDPLLAGYVSAPDQ------Y MPYFVLEIFDQYP-GIPGLFLACAYSGTLST--------------------------------ASTSINAMAAVTVEDLI RPKYPNISTKKLT-----LISKGLSLAYGCSCITVAALSSLLGGGVLQGS---------FTVMGVISGPLLGAFMLGMFF ASCN-TI--GVFAGLL-VGLVISLWVAVGGTIYPPSAEMMGVLPTFAEHCPLYNSSKG--------IIYGPAPVQNITHT LERP---ALADDLYALSYLYYGVVGTISTVIIGVIVSKFTGPTKRET--IAPGLLWWDLS-NSAAFQPMEKKDELEKTEA EETLL--------------------------------------------------------------------------- ------------KKDNTFHCTTF--LPNH---------------LPHSETSTYLLSEEYTPGNDSYCNGEKTYPIKTIHD YEDKESRV >Danio_rerio_SLC5A5_a -------------------------------------------------------------------------------- ------------MAMDSDRPP-----------------GFCLVDYAVFAAMLGVSVGIGLFQSLRKTPGRSK-------- ------------VDSFFTGGRGFSAVPVGLSLCASFMSAVQVLGVPSETYLYGFKFLYMCLGQGL--------------- -----------NSLMTAVLFVPVFYRLK-ITSSSQY---LGMRFGRG-MQLLGSLQFIVA----TLLYTGIVIFAP---A VILNQATGLNMWASLFSTGLICTFYTTVG---GMKA-VIWTDVFQIVVMLS--GFIAVFIQGTILAGG-PARVLEIANNG S-----------------------------RINFNDFAIDPQRRYSFWSFTVGG----TMVWLSMYGAN-QAQVQRYISC RTEKQAQLALLVNQVG--LCLIVSSAATCGIVMFALYSN--------------------CDPLKIGRISAPDQ------Y MPYLVLDIFRNHP-GFPGLFLACAYSGTLST--------------------------------VSTSINAMAAVTMEDVM KPWLITISQRKQL-----MLSRALSLFYGLGCITMAALSSLLDWGVLQGS---------FTVMGVVNGPLLGAFALGMFV PATN-KP--GVFSGVA-VGFCLSLWLAVGSTIYPPSPQIMGVLPTSAGQCLTTNATLNT-------TASVLASSVPLDYS ---------FQNIYSISYLYFGALSTSAVVLVGVVVSYITGPTKKDS--ISPGLLRWNLEQKPCDASCHI---------L NETIT--------------------------------------------------------------------------- ------------LNPTEILLTPK-ELFPI---------------AADKQDILLTKGEI---------------------- -------- >Tetraodon_nigroviridis_SLC5A5_a -------------------------------------------------------------------------------- ----------MNRSSSEGSRP-----------------GFVLADYSVFAAMLVVSVAIGLFHALRKSSKGTS-------- ------------VDDFFTGGRSMSAVPVGLSLCASFMSAVQVLGVPSEAYYHGFKFIYMCLGQSI--------------- -----------NSLLTAFLFLPVFFRLG-ITSTNQY---LEMRFGRG-MQLLG-FQFLVA----TLLYTGIVIYAP---A LILNQATGLNIWVSLFSTGIICTVYTTLG---GMKA-VIWTDVFQMCVMLS--GFVATYIHGTVLVGG-PQTVLDIARNG S-----------------------------RINFYDLDPDPRKRYTFWSLVVGG----ALVWLSMYGVN-QAQVQRYISC RTERQAQLALLVNQVG--LCLIVSSAATCGIVMFAYYAD--------------------CDPLKSGRVTSPDL------Y MPYFVLDIFQSHP-GFPGLFLACAYSGTLST--------------------------------VSTSINAMAAVTLEDLL KPCLRHTNQKKIM-----LISRGLSLLYGVGCMTVAALSSLLDWGVLQGS---------FTVMGVVSGPLLGVFILGMFF PAAN-KL--GAFCGFT-AGFSVSLWLAIGSTLYPPSAETIGILQSYVGKCGFDNLTMTA------APPRDLEAVSILRDN SGQGS--RGLQFLYSFSYLYFGAMATSTVVLVGLVVSYVNGPTKRGH--IPEGLLWWDLKKKHVSSGDK----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Gasterosteus_aculeatus_SLC5A5_a -------------------------------------------------------------------------------- --------------MEEHQPA-----------------GLFLADYAVFSAMLLVSMGIGLFQALKKGPGEAT-------- ------------ADDFFTGGRSMPAVPVGLSLCASFMSAVQVLGVPSEASRYGYKFLYMCLGQSI--------------- -----------SSLLTAYLFLPVFYRLG-ITSTNQY---LKLRFGHG-MQLLGSIQFLVA----TLLYTGIVIYAP---A LILNQATGLNMWVSLFSTGIICTLYTTLG---GMKA-VIWTDVFQIIVMLA--GFVAIFIHGTVLVGG-PATVLEIAKNG S-----------------------------RINFNDFSVDPRQRYSFWSLSVGG----ASVWLSMYGVN-QAQVQRYISC RTEKDAQWALFVNQVG--LCLIVSSAATCGIVMFAYYIN--------------------CDPLKSGIISAPDLM----KY MPYFVLDIFRNHS-GFPGLFLACAYSGTLST--------------------------------ASTSINAMAAVTMEDLL RPRLRLVTQKKLI-----LISKGLSFLYGVGCITVAALSSLLDWGVLQGS---------FTVMGVVSGPILGVFILGMFV PATN-RL--GAFSGFL-VGFCGSLWLAVGTTLYPPSEETMGVLPSYTSGCGLSNITVNSN-----SPPQEQHSISTLHFP DQQG----GLLDFYSVSYLYFGAIATSSVVLVGLLVSYATGPTQRSH--IKEGLLWWDLNKTEIEVASEH---------R RNVLK--------------------------------------------------------------------------- ------------DRPQLVPLRDM-RKEDA---------------KEETTDVGNIESPLRLKVMNSY-------------- -------- >Ciona_intestinalis_SLC5A5 -------------------------------------------------------------------------------- -------------MSNLEDQRS-----------------FSAGDYVVFGCLFFVSALIGLFFAYRDRKKKS--------- ------------AENYLLAGRTMSGWPVALSLTASFMSAITVLGTPAEVYIYGTMFWWFFIAYTI--------------- -----------VAIVTATIFVPVFYKLG-ISSTYEY---LEMRFDRS-VRIAGTCAFIIQ----TVLYMGMVMYMP---A LALNKVTGLSLIVSIVVTSLVCIFYTCIG---GMKA-VVWNDVVQCFVMWV--GFVAIIIKGSSDAGG-ISKVISIANEN G-----------------------------RIDFWRFDLDPRIRHSFWSIIIGG----SLMWLSVYAIN-QSMVQRYLSC RSLAQAKLSLYLNDIG--LFLVISLASLTGLIMFAVYNK--------------------CDPLTSGKVEKSD------QL IPYLVMDILHSLP-GIPGIFVAAAYSGTLST--------------------------------VSTGINALACSTYEDLI KPAKPDISDSKAV-----LISKILVIIYGLLGLGVAFLSSLLD-KVLTMA---------LKMFGIIGGPLLGIFCLGIFT PVANSK---GALAGLI-GGLAAGLWLAVGSYMYPPTVEFTRALPLPTVGCIGLNV------------------TSSSTMV PEY---TGLANTLYALSYCHYSTFLVLFTWTLGVIVSLLTGG-LKSR--HDVDPRLLAFGGDEVLINLQVDLKRLHVLNL TL------------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------- >Ciona_savignyi_SLC5A5 -------------------------------------------------------------------------------- ---------------------T-----------------FSTADYAVFGSLFLVSAFIGLYFAFVDRNKKT--------- ------------SENYLLAGRSMNGWPVALSLTASFMSAITVLGTPAEIYIYGTMFWWFMISYTI--------------- -----------VAIVTATVFVPVFYKLG-ISSTYEY---LEMRFGRS-VRVAGTCAFILQ----TVLYG-MVMYMP---A LALNKVTGLSLIVSIVATSLVCIFYTCIG---GMKA-VVWNDVVQCVVMWI--GFVAIIVKGTSDVGG-ISKVFDINSEH G-----------------------------RIDFLRFDLDPRVRHSVWSIVIGG----SLMWLSVYAIN-QSMVQRYLSC RNLFQAKLSLYINDVG--LFFVLGLASLLGLVMFAVYSK--------------------CDPLTSGEVKKSD------QL IPYLVMDILHSVP-GIPGIFVAAAYSGTLSTSKLKLQNAVHPLYNSFPHPLENCILWNIFYSTVSTGINALACSTYEDLI KPVKPDISEKRAV-----LISKILVIIYGLLGLGVAFLASLLD-KVLTMA---------LKMFGIIGGPLLGVFFLGMFT PMANSK---GALTGLI-GGLMAGMWLAVGSYNYPPSAEFTRALPLPTDSCVGLNVRL----PLRGCNGFNVINVTAAVET PVY---SGLANSLYALSYCHYSTVSVLVTCVLGILVSLATG-----------------------------KIYRI----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Homo_sapiens_SLC5A6 ------------------------------------------------------------------------------MS VGVSTSAPLSPTSGTSVGMST------------------FSIMDYVVFVLLLVLSLAIGLYHACRGWGRHT--------- ------------VGELLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFL--------------- -----------GLLIPAHIFIPVFYRLH-LTSAYEY---LELRFNKT-VRVCGTVTFIFQM----VIYMGVVLYAP---S LALNAVTGFDLWLSVLALGIVCTVYTALG---GLKA-VIWTDVFQTLVMFL--GQLAVIIVGSAKVGG-LGRVWAVASQH G-----------------------------RISGFELDPDPFVRHTFWTLAFGG----VFMMLSLYGVN-QAQVQRYLSS RTEKAAVLSCYAVFP--FQQVSLCVGCLIGLVMFAYYQE--------------------YPMSIQQAQAAP------DQF VLYFVMDLLKGLP-GLPGLFIACLFSGSLS--------------------------------TISSAFNSLATVTMEDLI RPWFPEFSEARAI-----MLSRGLAFGYGLLCLGMAYISSQMG-PVLQAA---------ISIFGMVGGPLLGLFCLGMFF PCANPP---GAVVGLL-AGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLT------------VATVTTLMPLTT FSK---PTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGR-MRGR--SLNPATIYPVLPKLLSLLPLSCQKRLH--CR SYGQDH-LDTGL-------------------------------------------------------------------- ---------FPEKPRNGVLGDSR--------------------DKEAMAL--DGTAYQGSSSTCILQETSL--------- -------- >Mus_musculus_SLC5A6 ------------------------------------------------------------------------------MS V-ASTAAPFHTTSGSSGAIST------------------FSVVDYVVFGLLLVLSLVIGLYHACRGWGHHT--------- ------------VGELLMADRKMGCLPVALSLLATFQSAVAILGAPAEIFRFGTQYWFLGCSYFL--------------- -----------GLLIPAHIFIPVFYRLH-LTSAYEY---LELRFNKA-VRICGTVTFIFQM----VIYMGVALYAP---S LALNAVTGFDLWLSVLALGIVCNIYTALG---GLKA-VIWTDVFQTLVMFL--GQLVVIIVGAARVGG-LGHVWNVTSQH G-----------------------------LISGINLDPDPFVRHTFWTLAFGG----VFMMLSLYGVN-QAQVQRYLSS HSERAAVLSCYAVFP--CQQVALCMSCLIGLVMFAYYNM--------------------YSMSPELKQAAP------DQL VLYFVMDLLKDMP-GLPGLFVACLFSGSLS--------------------------------TISSAFNSLATVTMEDLI QPWFPQLTETRAI-----MLSRGLAFAYGLVCLGMAYISSHLG-SVLQAA---------LSIFGMVGGPLLGLFCLGLFF PCANPL---GAIVGLL-TGLTMAFWIGIGSIVSRMSSAVAPPPLNGSSSFLPANVT------------VAAVTTVMP-ST LSK---PTGLQHFYSLSYLWYSAHNSTTVIVVGLIVSLLTGG-MRGR--SLNPGTIYPVLPKLLALLPLSCQKRLC--WR SHSQDIPVIPNL-------------------------------------------------------------------- ---------FPEKMRNGVLQDST--------------------DKERMAE--DGLVHQPCSPTYVVQETSL--------- -------- >Pan_troglodytes_SLC5A6 ------------------------------------------------------------------------------MS VGVSTSAPLSPTSGTSVGMST------------------FSIVDYVVFVLLLVLSLAIGLYHACRGWGRHT--------- ------------VGELLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFL--------------- -----------GLLIPAHIFIPVFYRLH-LTSAYEY---LELRFNKT-VRVCGTVTFIFQM----VIYMGVVLYAP---S LALNAVTGFDLWLSVLALGIVCTVYTALG---GLKA-VIWTDVFQTLVMFL--GQLAVIIVGSAKVGG-LGRVWAVASQH G-----------------------------RISGFELDPDPFVRHTFWTLAFGG----VFMMLSLYGVN-QAQVQRYLSS RTEKAAVLSCYAVFP--FQQVSLCVGCLIGLVMFAYYQE--------------------YPMSIQQAQAAP------DQF VLYFVMDLLKGLP-GLPGLFIACLFSGSLS--------------------------------TISSAFNSLATVTMEDLI RPWFPEFSEARAI-----MLSRGLAFGYGLLCLGMAYISSQMG-PVLQAA---------ISIFGMVGGPLLGLFCLGMFF PCANPP---GAVVGLL-AGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLT------------VATVTTLMPLTT FSK---PTGLRRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGR-MRGR--SLNPATIYPVLPKLLSFLPLSWQKRLH--CR SYGQDHLMDTGL-------------------------------------------------------------------- ---------FPEKPRNGVLGDSR--------------------DKEAMAL--DGTAYQGSSSTCILQETSL--------- -------- >Gorilla_gorilla_SLC5A6 ------------------------------------------------------------------------------MS VGVSTSAPLSPTSGTSVGMST------------------FSIVDYVVFVLLLVLSLAIGLYHACRGWGRHT--------- ------------VGELLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRYGTQYWFLGCCYFL--------------- -----------GLLIPAHIFIPVFYRLH-LTSAYEYTQYLELRFNKT-VRVCGTVTFIFQMM-QQVIYMGVVLYAP---S LALNAVTGFDLWLSVLALGIVCTVYTALG---GLKA-VIWTDVFQTLVMFL--GQLAVIIVGSAKVGG-LGRVWAVASQH G-----------------------------RISGFELDPDPFVRHTFWTLAFGG----VFMMLSLYGVN-QAQVQRYLSS RTEKAAVLSCYAVFP--FQQVSLCVGCLIGLVMFAYYQE--------------------YPMSIQQAQAAP------DQF VLYFVMDLLKGLP-GLPGLFIACLFSGSLS--------------------------------TISSAFNSLATVTMEDLI RPWFPEFSEARAI-----MLSRGLAFGYGLLCLGMAYISSQMG-PVLQAA---------ISIFGMVGGPLLGLFCLGMFF PCANPP---GAVVGLL-AGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLT------------VATVTTLMPLTT FSK---PTGLRRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGR-MRGR--SLNPATIYPVLPKLLSLLPLSCQKRLH--CS SYGQDHLMDTGL-------------------------------------------------------------------- ---------FPEKPRNGVLGDSR--------------------DKEAMAL--DGTAYQGSSSTCILQETSL--------- -------- >Bos_taurus_SLC5A6 ------------------------------------------------------------------------------MS MGLSTATPLPPASDTDVVTST------------------FSLVDYVVFVLLLVLSLAIGLYHAYRGWGRHS--------- ------------IGQLLLADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFL--------------- -----------GLLIPAHVFIPIFYRLH-ITSAYEY---LELRFNKA-VRVCGTVTFIFQM----VIYMGVVLYAP---S LALNAVTGFDLWLSVLTLGIVCTIYTALG---GLKA-VIWTDVFQTLVMFL--GQLAVIIVGSAKVGG-LGHVWEVASQH G-----------------------------LISGIELDPDPFVRHTFWTLAFGG----VFMMLSLYGVN-QAQVQRYLSS RTEKAAVLSCYAVFP--CQQVALSMGCLIGLVMFTYYQE--------------------YPMSTQQSQAAP------DQF VLYFVMDLLRGLP-GLPGLFVACLFSGSLS--------------------------------TISSAFNSLATVTMEDLI RPWFPHVSEVRAT-----MLSRIIAFGYGLLCLGMAYISSQMG-PVLQAA---------ISIFGMVGGPLLGLFCLGMFF PCANPP---GAIVGLL-AGLIMAFWIGIGSIVTSMGSGRALSPPNGSSFSLSSNLT------------AVTMATLMPSTA ASK---PTGLQRLYSLSYLWYSAHNSTTVIVVGLAVSLLSGG-MRGR--TVDPRTIYPVLPKLLALLPLSCQKRLP--CR AGSQDLSLEACM-------------------------------------------------------------------- ---------FPEKMSNGMLRGSR--------------------DQVDMAVPEEGPVQPGISPTFILQETSL--------- -------- >Monodelphis_domestica_SLC5A6 ------------------------------------------------------------------------------LY SGVSPSTIALSTANHAKPPPE------------------FTLVDYGVCILLLVLSLAIGLYYARRGRGQNT--------- ------------VRQFLLANRSMGSLPVALSLLATFQSAVAVL-VPGEIYRFGTEYWFL-CSYII--------------- -----------GLLVPAHIFIPIFYRLN-ISSAYEY---LELRFTKT-VRLCGTLTFIFQM----VIYMGVVLYAP---A LALNAVTGFDLWGSVLALGIVCTIYTSLG---GLKA-VIWTDVFQTVVMFL--GQIAIVIVGAAKVGG-LGRVWDVASQH G-----------------------------RISGIDLNPDPFVRHTFWTLAIGG----IFMMLSLYGVN-QAQVQRYLSS HTERAAILSCYAVFP--CQQVTLCIGSLIGLVMFVYYLD--------------------YPLSPEQAQISS------DQM VLHFVMDILGGLP-GLPGLFVACLFSGSLS--------------------------------TISSAFNSLATVTIEDLI RPHFPEISEERAT-----LISKGLAVAYGLICLGMAYVSSLMG-PVLQAA---------ISIFGMIGGPLLGLFCLGIFF PCANST---GAVLGLL-AGLIMAFWIGIGNMVSNMTSKIVVPPPNGTGLPSYRNMT------------IVTVTTLMP-FT VSQ---PTGIQRFYNLSYLWYSAHSSTTVIIMGLLVSLLTGG-TRGQ--PPNPRTIYPVLPRLFALLPISCRNRLP--CQ GYNQDLSYETDT-------------------------------------------------------------------- ---------VPEKMRNGMLTSYG--------------------EEEVVVMPEQGHIQGDHGHTFILQETSL--------- -------- >Danio_rerio_SLC5A6_a -------------------------------------------------------------------------------- -------------MGDTVQMH------------------FSTVDYVIFVVLLVASAGIGLYYAFSGGRQRT--------- ------------TQEFLLADRSMRCLPVSLSLLATFQSAVAILGAPSEIYTYGTQYWFLGCSYFL--------------- -----------GLLIPAHIFIPVFYRLR-LSSAYEY---LELRFSKS-VRICGTVTFIF----QMVIYMGVVLYAP---A LALNAVTGFDLWGAVLAMGLVCTLYTALG---GLKA-VIWTDVFQTIVMFA--GQLAVIVVGTHQAGG-IAEVWRKAQNG S-----------------------------RIAGLDLNPDPLERHTFWTLGVGG----VFLMLALYGVN-QAQVQRYLSS RTEKEAIMSCYAVFP--CQQVVLTLGCLMGLVMYARYGE--------------------ESPLDQGYVTTN------DQM VLYFVMDVLRDLP-GLPGLFVACLFSGALS--------------------------------TISSAFNSLATVTMEDLI KPHVPAMTEARAT-----LLSKMLALAYGLVCLAMAYIASLMG-SVLQAA---------LSIFGMVGGPLLGLFCLGMFF PWANST---GALVGLA-SGLVMAFWIGIGSFVSRMS-PSALPVINATIIPDVGNMT------------TAVMTTLTT-TK P--R--PSGVQALYSLSYMWYSAHNSATVVVVGLVVSFLTGP-WKEK--DLNPGTVYPVLGNLLFFLPQRYREKLC--CV TPLED--KSKDL-------------------------------------------------------------------- ---------DRQPYQMAQKESNGVACTKE----EDK--------LREEEGERVTAQPTCNLA-HTLQETAL--------- -------- >Tetraodon_nigroviridis_SLC5A6_a -------------------------------------------------------------------------------- -------------VAMATKMH------------------FTTVDYVIFALLLVASAGIGLFYAFSGGRQRT--------- ------------TQEFLMADRSMSCLPVSLSLLATFQSAVAILGAPSEVYTFGTQYWFLGCSYFL--------------- -----------GLLIPAHVFIPVFYRLR-LSSAYEY---LELRFNKT-VRICGTVTFIF----QMIIYMGVVLYAP---A LALNAATGFNLWGAVLAMGLVCTLYTALG---GLKA-VIWTDVFQTVVMFA--GQLAVIVVGAGQAGG-MAEVWRKAVNG S-----------------------------RVAGLDLNPDPLERHTFWTLGVGG----VFLMLALYGVN-QAQVQRYLSS RTEKQAIMSCYVVFP--CQQIVLCLGCLMGLVMFARYGE--------------------DSPLDRGYVQTK------DQM VVYFVMDVFRDLP-GLPGLFVACLFSGALS--------------------------------TISSAFNSLATVTMEDLI KPHFPNMTETKAT-----FLSKGLALVYGLVCLAMAYLASLMG-SVLQAA---------FSIFGMIGGPLLGLFCLGMFF PCANST---GAVLGLL-AGLAMAFWVGIGSFVMRASSPGVVPPLNNTIF---DNVT------------ASVGPVLQT-AT P--R--PVGLEALYSLSYMWYSAHNSTTVVLVGLVVSLLTGP-MKEK--DLRPGTVFPVLGTLLFFLPERYKEKLC--CA TALAS--EPRDV-------------------------------------------------------------------- ---------QAKPYRTGQTDG---AFASE-----DE--------SEGEEAQTKIVPSSGQTLPPVVQETAL--------- -------- >Gasterosteus_aculeatus_SLC5A6_a -------------------------------------------------------------------------------- -------------MGNVVLMH------------------FTTVDYIIFALLLVASTGIGLFYAFSGGRQRT--------- ------------TQEFLMADRSMSCLPVSLSLLATFQSAVAILGAPSEVYTFGTQYWFLGCSYFL--------------- -----------GLLIPAHVFIPILYRLR-LSSAYEY---LELRFNKT-VRICGTVTFIF----QMVIYMGVVLYAP---A LALNAVTGFDLWGAVLAMGLVCTLYTALG---GLKA-VIWTDVFQTVVMFA--GQLAVIVVGASQAGG-MAEVWRKAVNG S-----------------------------RISGLDLNPDPLERHTFWTLGVGG----VFLMLALYGVN-QAQVQRYLSS RTEREAVMSCYVVFP--CQQIVLCLGCLMGLVMFARYGE--------------------DSPLDKGYVKTN------DQM VLYFVMDVFKDLP-GLAGLFVACLFSGALS--------------------------------TISSAFNSLATVTMEDLI KPHFPNMTEAKAT-----LLSKGLALVYGLVCLAMAYLASIMG-SVLQAA---------FSIFGMVGGPLLGLFCLGMFF PWANST---GAVVGLV-AGLAMAFWIGIGSFVMRMS-DSIP--LNTTALPLFDNMT------------TAVMTTVNA-TT PKLR--PSGVQALYSLSYMWYSAHNSTVVVVVGLLVSLLTGP-MKEK--DLTPGTVFPVLGTLLFFLPERYREKLC--CV TPLSTPHESKDT-------------------------------------------------------------------- ---------TAQPYQMARKDGNGAALCKEDTVTEDKEMESDRAQTEEEDVEPRTPRPSCKLTGQTVEETVF--------- -------- >Tetraodon_nigroviridis_SLC5A6_b -------------------------------------------------------------------------------- -------------MDPSDQKH------------------FTTADYVIFAVLLAASLGIGVYHALTGGRQRT--------- ------------TQEFLMADRSMGCLPVSLSLIASFQSAVAIIGVPGEIYTHGTQYWFIGCAYIL--------------- -----------GLLIPAYVFIPVLYRLR-LSSAYQY---LELRFSKP-VRICGTLTFIFPD--EKVVYMGVCVYAP---A SALNAVTGFELWGAVLATGLVCTLYTTLG---GLKA-VIWTDVFQTGVMFA--GQLAVIVVGVQQAGG-ASEVWRKALEG N-----------------------------RIASLDLNPDPTVRYTFWTLGVGG----VFLMLSLYGVN-QAQVQRYLSS RTEKEAVRSCLMVFP--SLQLALALSCMMGLVMFARYCG--------------------EEHSHKLATSQR------DAM VIYFVMDMLQGLP-GLPGLFIACLFSAALS--------------------------------TISSAFNSLATVTMEDLI KPHFPSMTEARAT-----LLSKALAMSYGLLCLAMAYLTHLMRESVLLVA---------LKIFGIVGGPILGLFCLGMFF PWANST---GAVTGWA-AGLLVAFWIGIGSIVTQTP-STSLLPSGCKPILLD----------------ILLSHILSS-LL LS-P--PPALKRFYSLSYMWYSGVNSFTVITVGLVVSFLTGP-MKEE--DVMPGTIYPLLGKMLFFLPEHLKKKLC--CV TPLGER-------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Gasterosteus_aculeatus_SLC5A6_b -------------------------------------------------------------------------------- -------------MDPSDQKH------------------FTAVDYVIFAVLLAASMGIGLYHALSGGRQRT--------- ------------TQEFLMADRSMSCLPVSLSLIASFQSAVAIIGVPAEIYTHGTQYWFIGCAYFL--------------- -----------GLLIPAHVFIPVLYKLR-LSSTYEY---LELRFSKA-VRICGTLTFIF----QTVVYMGVCVYTP---A FALNAVTGFELWGAVLATGLACTLYTTMG---GLKA-VIWTDVFQTAVMFA--GQLAVIVVGVNQTGG-ASEVWRKVWEG N-----------------------------RISALNLNPDPTERHTFWTLGVGG----VFLMLSLYGVN-QAQVQRYLSA RTEKEAVRSCYMAFP--SLQLSLALSCVMGLVMFARYCG--------------------EDHSAMLPTSSNQMNLTSDAM VIYFVMDMLEGFP-GLPGLFVACLFSAALS--------------------------------TISSAFNSLATVTMEDLV KPHVPAMTEARAT-----LVSKALAMSYGLLCLAMAYLTHLMDVSVLNVA---------LKLFGMVGGPVLGLFCLGMFF PWANPT---GAMAGLG-AGLALSFWVGIGSIFNRSS-GARPLSAGCRAALLSDNST------------SAVHTALDN-LT LS-K--PSGLNRFYSLSYMWYSAFSCFAVILIGLIISFLTGP-MKEE--DVTPGTIYPVFGKLLCFLPEHLKKKLC--CV TP------------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------- >Drosophila_melanogaster_SLC5A6 -------------------------------------------------------------------------------- ----------------MPVGT------------------FDAWDAAVLITILVISALIGIYYRYTGGKQKT--------- ------------TQEYLMADQSMTTFPVSFSLMASFMSAISLMGVSNESYEFGTIFCVINIAYVL--------------- -----------STPIAAYFFLPVFYRMR-TTSVYEY---LERRFGQA-TRLSASLAFTVQ----MVLYMGIALYAP---A LALEAVTGIHRSMAIVVIGLVCTFYSTLG---GLKA-VLITDVFQSFLMFA--AIYAVI-AVSAIKAGGFAAIWDVAVER G-----------------------------RVNFIEFSLDPTVRHTWWSLIIGG----MVTYLSLYGVN-QTQVQRLLSV RNLKSAQSALWWNLPI--LGMLSFSTIFSGLSIFYYYRD--------------------CDPLLKGRIDKRD------QI MPLFALETMGQYP-GLCGLFVSGIFSASLST--------------------------------ISSAVTSLSAVTLEDYL KPLYKAIFKRTLIDSKSTMPTKIVACIFGLLCIGLAFVAGSMG-GVLQAS--