>Homo_sapiens_RNF13 -------------------------------------------------------------------------------- --------------------MLLSIGMLMLSATQVYTILT-VQLFAFLN------------------------------- LLPVEADILAYNFENASQT----------------FDDLPARFGYRLPAEGLKGFLINSK-------PENACEPIVPPP- VK--------DNSSGTFIVLIRRLD--CNFDIKVLNAQRAGYKAAIVHNV----DSDDLISMGSNDIEV--LKKIDIPSV FIGESSANSLKDEFTYEKGGHLILVPEFSL-----------------------------PLEYYLIPFLIIVGICLILIV IFMITK----FVQDRHRARRNRLRKD--QLKKLPVHK-FKKG-----------------------------DEYDVCAIC LDEYEDGDKLRILPC-SHAYHCKCVDPWLTKTKK---TCPVCKQKVVPSQ------------------------------ ---------GDSDS---DTDSSQEENE-VTEHTPL---------------LRPLASVSAQ-------------------- -------------------------------------------------------------------------------- --------------------------------------------SFGALSESRSHQNMTESSDYEE-------------- ---------DDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Pan_troglodytes_RNF13 -------------------------------------------------------------------------------- --------------------MLLSIGMLMLSATQVYTILT-VQLFAFLN------------------------------- LLPVEADILAYNFENASQT----------------FDDLPARFGYRLPAEGLKGFLINSK-------PENACEPIVPPP- VK--------DNSSGTFIVLIRRLD--CNFDIKVLNAQRAGYKAAIVHNV----DSDDLISMGSNDIEV--LKKIDIPSV FIGESSANSLKDEFTYEKGGHLILVPEFSL-----------------------------PLEYYLIPFLIIVGICLILIV IFMITK----FVQDRHRARRNRLRKD--QLKKLPVHK-FKKG-----------------------------DEYDVCAIC LDEYEDGDKLRILPC-SHAYHCKCVDPWLTKTKK---TCPVCKQKVVPSQ------------------------------ ---------GDSDS---DTDSSQEENE-VTEHTPL---------------LRPLASVSAQ-------------------- -------------------------------------------------------------------------------- --------------------------------------------SFGALSESRSHQNMTESSDYEE-------------- ---------DDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gorilla_gorilla_RNF13 -------------------------------------------------------------------------------- --------------------MLLSIGMLMLSATQVYTILT-VQLFAFLN------------------------------- LLPVEADILAYNFENASQT----------------FDDLPARFGYRLPAEGLKGFLINSK-------PENACEPIVPPP- VK--------DNSSGTFIVLIRRLD--CNFDIKVLNAQRAGYKAAIVHNV----DSDDLISMGSNDIEV--LKKIDIPSV FIGESSANSLKDEFTYEKGGHLILVPEFSL-----------------------------PLEYYLIPFLIIVGICLILIV IFMITK----FVQDRHRARRNRLRKD--QLKKLPVHK-FKKG-----------------------------DEYDVCAIC LDEYEDGDKLRILPC-SHAYHCKCVDPWLTKTKK---TCPVCKQKVVPSQ------------------------------ ---------GDSDS---DTDSSQEENE-VTEHTPL---------------LRPLASVSAQ-------------------- -------------------------------------------------------------------------------- --------------------------------------------SFGALSESRSHQNMTESSDYEE-------------- ---------DDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Macaca_mulatta_RNF13 -------------------------------------------------------------------------------- --------------------MLLSIGMLMLSATQVYTILT-VQLFAFLN------------------------------- LLPVEADILAYNFENASQT----------------FDDLPARFGYRLPAEGLKGFLINSK-------PENACEPIVPPP- VK--------DNSSGAFIVLIRRLD--CNFDIKVC-VYTSISSLSFISSM----TLDKIILLFFYTVEV--LKKIDIPSV FIGESSANSLKDEFTYEKGGHLILVPEFSL-----------------------------PLEYYLIPFLIIVGICLILIV IFMITK----FVQDRHRARRNRLRKD--QLKKLPVHK-FKKG-----------------------------DEYDVCAIC LDEYEDGDKLRILPC-SHAYHCKCVDPWLTKTKK---TCPVCKQKVVPSQ------------------------------ ---------GDSDS---DTDSSQEENE-VTEHTPL---------------LRPLASVSAQ-------------------- -------------------------------------------------------------------------------- --------------------------------------------SFGALSESRSHQNMTESSDYEE-------------- ---------DDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Bos_taurus_RNF13 -------------------------------------------------------------------------------- --------------------MLLSIGMLMLSATQVYTILT-VQLFAFLN------------------------------- LLPVEADILAYNFENASQT----------------FDDLPARFGYRLPAEGLKGFLINSK-------PENACEPIVPPP- VR--------DNSSGTFIVLIRRLD--CNFDEKVLNAQRAGYKAAIVHNV----DSDDLISMGSNDIEV--LKKIDIPSV FIGESSANSLKDEFTYEKGGHIILVPEFSL-----------------------------PLEYYLIPFLIIVGICLILIV IFMITK----FVQDRHRARRNRLRKD--QLKKLPVHK-FKKG-----------------------------DEYDVCAIC LDEYEDGDKLRILPC-SHAYHCKCVDPWLTKTKK---TCPVCKQKVVPSQ------------------------------ ---------GDSDS---DTDSSQEENE-VSEHTPL---------------LRPLASASTQ-------------------- -------------------------------------------------------------------------------- --------------------------------------------SFGALSESRSHQNMTESSDYEE-------------- ---------DDN-DTDSSDAENEINEHSVVVQLQPNGERDYNIANTV--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Loxodonta_africana_RNF13 -------------------------------------------------------------------------------- --------------------MLLSIGMLMLSATQVYTILT-VQLFAFLN------------------------------- LLPVEADILAVSTENASQT----------------FDDLPARFGYRLPAEGLKGFLINSK-------PENACEPIVPPP- LK--------DNSSGTFIVLIRRLD--CNFDVKVLNAQRAGFKAAIVHNV----DSDDLISMGSNDIEV--LKKIDIPSV FIGESSANSLKDEFTYEKGGHIVLVPEFSL-----------------------------PLEYYLIPFLIIVGICLILIV IFMITK----FVQDRHRARRNRLRKD--QLKKLPIHK-FKKG-----------------------------DEYDVCAIC LDEYEDGDKLRILPC-SHAYHCKCVDPWLTKTKK---TCPVCKQKVVPSQ------------------------------ ---------GDSDS---DTDSSQEENE-VSEHTPL---------------LRPLASVSAQ-------------------- -------------------------------------------------------------------------------- --------------------------------------------SFGALAESRSRQNTTESSDYEE-------------- ---------DDHEDTDSSDAENDISEHSVVVQLQPDGGRDYNIANTV--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Takifugu_rubripes_RNF13_a -------------------------------------------------------------------------------- --------------------MLLSLGMLMLSATQIYTIFT-VQLFAFLN------------------------------- LLPVEADIAAYTFDNKTES----------------FEDLPARFGYRLPTEGLKGFLIGAR-------PENACEPIEPPP- -R--------DNLTGAFIVLIKRFE--CNFDVKVLNAQKAGYRAAIVHNV----NSDDLISMGSNDLDI--MKQIDIPSV FVSEETANSLKEDYIYDKGGHVVLMPDFSL-----------------------------PLEYYLIPFLIIVGICLILIV VFMITK----FVQDRRRARRSRLHKD--QLKKLPIHK-YKK--G---------------------------DSYDVCAIC LDEYEEGDKLRVLPC-SHAYHSKCVDPWLTKTKK---TCPVCKQKVVPSQ------------------------------ ---------GDSDSDSEEGDSGPDENE-VSESTPL---------------LRSLASTSAH-------------------- -------------------------------------------------------------------------------- --------------------------------------------SFGTMSAESRSEQDQDSSEY-D-------------- ------------EELDSSDSEE-VTVETVVVQMQQPRSDGRDHDPARV-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Tetraodon_nigroviridis_RNF13_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------RR-------P-----CLVPP-- --------------------------------QVLNAQKAGYRAAIVHNV----NSDDLISMGSNDVDV--MKQIDIPSV FVSEETANSLKGGYLYDKGGHLVLMPDFSL-----------------------------PLEYYLIPFLIIVGICLILIV VFMITK----FVQDRRRARRSRLHKD--QLKKLPIHK-YKK--G---------------------------DSYDVCAIC LDEYEDGDKLRVLPC-SHAYHSKCVDPWLTKTKK---TCPVCKQKVVPSQ------------------------------ ---------GDSDSDSEEGDSGPDENE-ASESTPL---------------LRSLASTSAH-------------------- -------------------------------------------------------------------------------- --------------------------------------------SFGTMSAGSRSEHDQESSEY-D-------------- ------------EELDS------MTVETVVVQMQPPQ-----QDPTRV-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gasterosteus_aculeatus_RNF13_a -------------------------------------------------------------------------------- --------------------MLLSLGMLMLSATQIYTIFT-VQLFAFLN------------------------------- LLPVGADIAAYSFDNKTEN----------------FDDLPARFGYRLPSDGLKGFLIGAR-------PENACEPIEPPP- -R--------DNMTGAYIVLIKRFD--CNFDIKVLHAQKAGYKAAIVHNV----VSDDLISMGSNDLDI--MKQIDIPSV FVSEQTANSLKEDFAFDKGGHVVLMPDFSL-----------------------------PLEYYLIPFLIIVGICLILIV VFMITK----FVQDRHRARRSRLRKD--QLKKLPIHK-YKKDTG---------------------------DNYDVCAIC LDEYEEGDKLRVLPC-SHAYHSKCVDPWLTKTKK---TCPVCKQKVVPSQ------------------------------ ---------GDSDS--EEGGSGPDENEEVSESTPL---------------LRSLASTSAH-------------------- -------------------------------------------------------------------------------- --------------------------------------------SFGTMSGASRSEHEQESSDYED-------------- ------------DELDSSEEEEEVTVETVVVQMQQPCPEGLEHDL----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Strongylocentrotus_purpuratus_RNF13 -------------------------------------------------------------------------------- ---------------------MMLFSSRRSYQMKMDVGQVVVALVVLCT------------------------------- EIMQITADVIATSQHNDTTA---------------FQSVTAAFGSP-PDGQMQGLLVVAN-------PIEACGPIQ---- -VPPLL---PNVTGVY-FALIKRGS--CNFDKKVYNAQQARYMGAIVYND----EGNVLTTMSGSQ----YNKLIYIPSV FVGKDSGETLQGMNYSTGYHVVLLATESPS------------------------------LGFYFLPFISVTSTCLLFFA MYAIAK----YVRDQRRQRKARLSRD--HLKKLPIKX-XSSGDE-----------------------------YDICAIC LDDYEEGQKLRILPC-NHAYHCKCIDPWLTNNRR---TCPICKRKVIPPG------------------------------ ---------MADSDEE-SDSEAGDAPNENTPLLSS---------------MHSDNLSDHG-------------------- -------------------------------------------------------------------------------- --------------------------------------------AVGGLAETATPPPSPMTSVEGDDY------------ --------PPIDTLIKVESDSESSGSFPLEEAKGNIQDPPNSNVLSVTVHSENEIDPSTSSAPKV--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Apis_mellifera_RNF13 -------------------------------------------------------------------------------- ---------------MKQCCLS------------HQLQLWLMFLVFCVM------------------------------- CNRADILVFSAAARHQIEEE---------------FRDMPARFGGLIPSEGIKGMVVYAE-------PPTACHEIQGPPN STSY---------IGNWISLIARYN--CSFERKVRMAQKAGYDAVIIHNV----NSNKLEPMLAKDPTG-----IIIPSV FVSEITGLIIKENYLYDELYFVLINDDSPF----------------------------NIT-HLLLPFAIVVGICFLIMV IFMIVR----CIKDRRRQQRHRLPNS--SLKKIPTHK-YTKG-----------------------------DPYETCAIC LDDYAEGEKLRVLPC-AHAYHTKCIDPWLTKNRR---VCPVCKRKVFA-------------------------------- ----------ADEQV---VTDE--SDSDADDTTPL---------------IREGHQGTQG----------GTFSR----- -------------------------------------------------------------------------------- ---------------------QRENPFNRARRSQTRQH------DIIHFNSSSDSEELLDTT------------------ ------------DEEASVSAGE----PSSGTVFRPFDIHSING--------ELPDLECSVSSTKPH--TVNLYT------ ---------------------------------DVEEFPAP-------VVQITNCNIRTN---------SQTSNSGGSVP IESEATNFINTDSEK---IDIHV--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Anopheles_gambiae_RNF13 ------------------------------------------------------------------------------ML PQSLIMVKGGYARRPMNRAAHRSPKFVHHRQYHHRLVMLVAMVLMLAQP------------------------------- CVRADILVYQMLN-DQIIEE---------------FRDLPATFGGEIPDSGLKVLADRAD-------PPDGCTEMRPAPN ITS------------KFAVVIARYN--CSFEVKVRNAQQAGYAMVIVHNV----GSNDLEHMSANHPQD-----LLIPSV FVGESAGRSIIEAYLYDHDYALVITDDIPF----------------------------NISNNLIIPFAIVVGLCFIIMV LFMIIR----CIRERRRRMRHRLPAR--VLRKIGIVK-FAKG-----------------------------MRFDTCAIC LEDFVENERLRVLPC-RHAYHAICIDPWLTKNRR---VCPICKRRVIVRG------------------------------ ---------EARQRR---YSSDSMSSTNADESTPL---------------LNSTENSTSGSAAGVVTAPPATSSSSPVTA AVAPSGNSGAG--------------------------------------------------------------------- --------------------AQTAAAAAPQRDQQQLQQNAAPDSHVMEVPPSDDDDEMLDDRNVPSARWLLRGRTSSQQQ HQQQQQPQQQPLNESPYSPIGDNVATPSRWRFFQRFFTRSTAQSDTEGNNIQEPPAPAQAPSPQPFSPTVPLGTGNNILN AHLSGSFHGSEDTTDDELLDAMQRDRTKQRQFRSAPDMPSTSVGARLGVAALPNVNFNPAGGGANAPAAPAESSSGGGAP RRYPRQPMPRHERRRNGNNNSHIV-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Nematostella_vectensis_RNF13 -------------------------------------------------------------------------------- ----------------------MERTFLLAVLLTIFVSSGLGEDTTTLT------------------------------- DYNRICVIPLGQSVNETEKC---------------YEYGLADFG-QLLSRSIQGFGVLAS-------PKNACSTV----Q PIKSK------SNMFWFLVIE-DGG--CSFGEKAYMAQKGEYDAAIIYSL----TSDKIIDMESDEYG--RK-ADDIVAI HIGKTAAKELTRIDVLARNN---IVINPQYL-------------------------LLWNLEVYILPFAVIVGICFVLMG LFMISR----YYRHYLEKRRNRLSLT--NLRKIPTKK-FKKGDEYYDVCAICLDEYKEGDKLRILPCDHGDEYYDVCAIC LDEYKEGDKLRILPC-DHAYHCKCVDPWLTEGKR---TCPVCKRPVETSK------------------------------ ---------KKK-------QGIQGSADAEQG---H---------------HEHEPSETTP-------------------- -------------------------------------------------------------------------------- --------------------------------------------LIRPSTQTSTALPV---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Hydra_magnipapillata_RNF13 -------------------------------------------------------------------------------- -------------------------TYEMINWYYLLVICLQMVNLVSLT------------------------------- IYT----YPPAHS-NLSKLM---------------FHDVEADFG-SMPTEGISGALDLSI-------PYNACYHL----Y PAPKKD---LPNTNFFALIQE-SSG--CSYSEQVIHAQEAGYKGAIIYSR----TNNDPIIMGGD--------GPIIVAV YVKKSVGQDLKQFLYKTGST---IKIAPNDP-------------------------QMS-LSIYLVPFAIVVGVCFFFML AFSVGR----YVRYWLRIRRSRLSPA--NLKKIPTKK-FKKGDE-----------------------------FDVCAIC IEEYVQNDKIRILPC-NHAYHCKCVDPWLTSGKK---LCPVCKQTVESDL------------------------------ ---------KRTSKNV-IINGNDGNSNDVNGSSAL---------------TEESEDENTP-------------------- -------------------------------------------------------------------------------- --------------------------------------------LLAASQNLPNSGAMA--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Branchiostoma_floridae_RNF13 -------------------------------------------------------------------------------- ---------------------MFPCRPVPSYITVLYIYAVINLFLLLH-------------------------------- -VCTVDADVIVTDSINNTVN---------------FMDMPSNFGSQLPDMGIQGYLAAVN-------PPHACKAVG---- -PPP-----PNITELNPIALIRRGN--CDFDIKVLNAEKSGFKAAIVYND----ESDVILQMNGNKCKFVYYMEVTIPSV FVGLTDGMELQRYDWRTGSQVKLTPDFTIP------------------------------LHFYLLPFAIIVGICFVLML IFMVAK----FVRDRRRQRRSRLSKE--HLKKIPTKK-FKKGDE-----------------------------YDVCAIC LDDYEEGDKLRILPC-SHG---------RSYNRS---I------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Homo_sapiens_RNF43 -------------------------------------------------------------------------------- -----------------------MSGGHQLQLAALWPWLLMATLQAGFGR-----------------------------T GLVLAAAVESERSAEQKAIIR-----------VIPLKMDPTGKLNLTLEGVFAGVAEITP--AEGKLMQS--HPLYLCNA SDDDNLEPG-FISIVKLESPRRAPRP-CLSLASKARMAGERGASAVLFDITEDRAAAEQLQQP--LGLTWPVVLIWGNDA EKLMEFVYKNQKAHVRIELK----EPP-AWPD------------------------YDVWILMTVVGTIFVIILASVLRI RCRPRHSRPDPLQQRTAWAISQLATRRYQAS-CRQARGEWPDSGSSCSS------------------------APVCAIC LEEFSEGQELRVISC-LHEFHRNCVDPWLHQHRT----CPLCMFNITEGD-------------SFSQSLGPSRSYQ---- -------------EPGRRLHLIRQHPGHAHYHLPAAYLLGPSRS-AVARPPRPGPFLPSQ---EPGM----GPRHHRFPR AAHP--------------RAPGEQQRLAGAQ--HPYAQGWGLSHLQ-STSQH-----------------PA-ACPVP--- -----------------------------LRRARPPDSSGSGESYC---TERSGYLADGPASDSSS------------GP CHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPK------------------------------------ -------GDPQRVDMQPSVTS---RPRSLDSVVP-------TGETQVSSHVHYHRHRHHHYKKRF-----QWHGRKPGPE TGVPQSRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDASSICP----STSSLFNLQKSSLS ARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLC LTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEE-LEELCEQAV------------------------ - >Mus_musculus_RNF43 -------------------------------------------------------------------------------- -----------------------MSGGHQLQLAVLWPWLLMATLHAGFGH-----------------------------T GRVLAAAVESERSAEQKAVIR-----------VIPLKMDPTGKLNLTLEGVFAGVAEVTP--AEGKLMQS--HPLYLCNA SDDDNLEPG-FISIVKLESPRRAPRP-CLSLASKARMAGERGANAVLFDITEDRSAAEQLQQP--LGLTKPVVLIWGSDA AKLMEFVYKNRKAYVWIELK----EPP-AGAN------------------------YDVWILLTVVGTVFVIILASVLRI RCRPHHSRPDPLQQRTARAISQLATRRYQAG-CRRARAEWPDSGSSCSS------------------------TPVCAIC LEEFSEGQELRVISC-LHEFHRTCVDPWLYQHRT----CPLCMFNIVEGD-------------SFSQAPAASPSYQ---- -------------EPGRRLHLIRQHPGHAHYHLPSAYLLGPSRT-SVARTPRPRPFLPSQ---EPSM----GSRHQRLPR TSHL--------------RAPEEQQHLAVSP--HPYAQGWGLNRLR-CTSQH-----------------PA-ACPVA--- -----------------------------LRRARPHESSGSGESYC---TERSGYLADGPASDSSS------------GP CHGSSSDSVVNCTDVSLQGIHGSSSTFRSSLSSDFDPLVYCSPE------------------------------------ -------GDLQGKGIQPSVTS---RPRSLDSVVP-------RGETQVSSHIHYHRHRHHHYKRQF-----QWHGRKPGPE TGIPQSMPAASHT--QLEPSLPDQQLITPNPTASS-MLPNPQRPRALTEPAPGLAEASSPSPSPKPNPSGLLNLQKSSLT VRHPHRKRRGGPSEPLPTSLPPDLTVHTACPVFPHYSPRLAYPWPPEVHPLMFRPPGPDRRLLHEVPGPCYSSSQPVWLY LNPCQPLGPCLPGEGHSKWTFDSPEGRRCPYSHCQVLPAQPGSEEE-LEELCEQAV------------------------ - >Pan_troglodytes_RNF43 -------------------------------------------------------------------------------- -----------------------MSGGHQLQLAALWPWLLMATLQAGFGR-----------------------------T GLVLAAAVESERSAEQKAIIR-----------VIPLKMDPTGKLNLTLEGVFAGVAEITP--AEGKLMQS--HPLYLCNA SDDDHLEPG-FISIVKLESPRRAPRP-CLSLASKARMAGERGASAVLFDITEDRAAAEQLQQP--LGLTWPVVLIWGNDA EKLMEFVYKNQKAHVRIELK----EPP-AWPD------------------------YDVWILLTVVGTIFVIILASVLRI RCRPRHSRPDPLQQRTAWAISQLATRRYQAS-CRQARGEWPDSGSSCSS------------------------APVCAIC LEEFSEGQELRVISC-LHEFHRNCVDPWLHQHRT----CPLCMFNIIEGD-------------SFSQSLGPSRSYQ---- -------------EPGRRLHLIRQHPGHAHYHLPAAYLLGPSRS-AVARPPRPGPFLASQ---EPGM----GPRHHRFPR AAHP--------------RAPGEQQRLAGAQ--HPYAQGWGLSHLQ-STSQH-----------------PA-ACPVP--- -----------------------------LRRARPPDSSGSGESYC---TERSGYLADGPASDSSS------------GP CHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPK------------------------------------ -------GDPQRVDMQPSVTS---RPRSLDSVVP-------TGETQVSSHVHYHRHRHHHYKKRF-----QWHGRKPGPE TGVPQSRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVEASSICP----STSSLFNLQKSSLS ARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDRRLLPETPGPCYSNSQPVWLC LTPRQPPEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEE-LEELCEQAV------------------------ - >Gorilla_gorilla_RNF43 -------------------------------------------------------------------------------- -----------------------MSGGHQLQLAALWPWLLMATLQAGFGR-----------------------------T GLVLAAAVESERSAEQKAIIR-----------VIPLKMDPTGKLNLTLEGVFAGVAEITP--AEGKLMQS--HPLYLCNA SDDDNLEPG-FISIVKLESPRRAPRP-CLSLASKARMAGERGASAVLFDITEDRAAAEQLQQP--LGLTWPVVLIWGNDA EKLMEFVYKNQKAHVRIELK----EPP-AWPD------------------------YDVWILLTVVGTIFVIILASVLRI RCRPHHSRPDPLQQRTAWAISQLATRRYQAS-CRQARGEWPDSGSSCSS------------------------APVCAIC LEEFSEGQELRVISC-LHEFHRNCVDPWLHQHRT----CPLCMFNIIEGD-------------SFSQSLGPSRSYQ---- -------------EPGRRLHLIRQHPGHAHYHLPAAYLLGPSRS-AVARPPRPGPFLPSQ---EPGM----GPRHHRFPR AAHP--------------RAPGEQQRLAGAQ--HPYAQGWGLSHLQ-STSQH-----------------PA-ACPVP--- -----------------------------LRRARPPDSSGSGESYC---TERSGYLADGPASDSSS------------GP CHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPK------------------------------------ -------GDPQRVDMQPSVTS---RPRSLDSVVP-------TGETQVSSHVHYHRHRHHHYKKRF-----QWHGRKPGPE TGVPQSRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVEASSICP----STSSLFSLQKSSLS ARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDRRLLPETPGPCYSNSQPVWLC LTPRQPPEPHPPGEGPSEWSSDTTEGRPCPYPHCQVLSAQPGSEEE-LEELCEQAV------------------------ - >Macaca_mulatta_RNF43 -------------------------------------------------------------------------------- -----------------------MSGGHQLQLAALWPWLLMATLQAGFGR-----------------------------T GLVLAAAVESERSAEQKAIIR-----------VIPLKMDPTGKLNLTLEGVFAGVAEITP--AEGKLMQAKSHPLYLCNA SDDDNLEPG-FISIVKLESPRRAPRP-CLSLASKARMAGERGASAVLFDITEDRAAAEQLQQP--LGLTWPVVLIWGNDA EKLMEFVYKNQKAHVRIELK----EPP-AWPD------------------------YDVWILLTVVGTIFVIILASVLRI RCRPRHSRPDPLQQRTAWAISQLATRRYQAS-CRQAQGEWPDSGSSCSS------------------------APVCAIC LEEFSEGQELRVISC-LHEFHRNCVDPWLHQHRT----CPLCMFNIIEGD-------------SFSQSLGPSRSYQ---- -------------EPGRRLHLIRQHPGHAHYHLPAAYLLGPSQS-TVAWPPQPGPFLPSQ---EPGM----GPRHHRLPR AAHP--------------RAPGEQQRLAGAQ--HPYAQGWGLSHLQ-STSQH-----------------PA-ARPVP--- -----------------------------LRRARPPDSSGSGESYC---TERSGYLADGPASDSSS------------GP CHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDSLVYCSPE------------------------------------ -------GDPQRVDMHPSVTS---RPRSLDSVVP-------TGETQVSSHVHYHRHRHHHYKKRF-----QWHGRKPGPE TGVPSSRPPIPRTQPQPEPASPDQHVTRSNSAVPSGRLSNPQRPRALPEPAPGPVEASSICL----STSSLFNLQKSSLS ARHPQRKRRGCPSEPTPGSRPQDATVHPACQIFPHFTPSVAYSWSPEAHPLIFGPPGLDRRLLPETPGPCYSNSQPVWLC LTPHRSPEPHPPGEGPSEWSSDTAEGRPCPHPHCQVLSAQPGSEEE-LEELCEQAV------------------------ - >Bos_taurus_RNF43 -------------------------------------------------------------------------------- -----------------------MSGGHQLQLAALWPWLLMATLQAGFGR-----------------------------T GLVLAAAVESERSAEQKAIIR-----------VIPLKMDPTGKLNLTLEGVFAGVAEITP--AEGKLMQS--HPLYLCNA SDDDNLEPG-FISIVKLESPQRAPRP-CLSLASKARMAGERGASAVLFDITEDRAAAEQLQQP--LGLTWPVVLIWGHDA EKLMEFVYKNRKAHVRIELK----EPP-TWPD------------------------YDVWILLTVVGIIFVVILALVLRI RCRPRHSRPDPLQQRTAWAISQLATRSYRAG-CRGARKEWPDSGSSCSS------------------------APVCAIC LEEFSEGQELRVISC-LHEFHRTCVDPWLHQHRT----CPLCMFNIVEGD-------------SLSQSLGPSRAYQ---- -------------EPGRRLHLIRQHPGHAHYHLPAAYLLGPSRS-AVARPTRPGPFLPSQ---EPGV----GARHHRQPR TTHP--------------RAPGEPQRLAVAP--RPYAPGWGLSHLR-CTSQH-----------------PA-TCPAP--- -----------------------------PRRTRPHDSSGSGESYR---TERSGYLADGPASDSSS------------GP CHGSSSDSVVNCTDVSLQGIHGSSSTFRSSLSSDFDPLVYCSPE------------------------------------ -------GEPPGKAAQPSMAS---RPRSLDSVVP-------VGETQVSSHIHYHRHRHHHYRRRF-----RWHGRKADPE TAVPPSRPAVPRTQLQPEPPSPDLHATRCSPAALSGQPPAPQRPRALTEPAPGPPDASSSSP----AASSLFHLQKSSLS VRHPQRRRRGGPLEPTPASRSQDLTTHPTCQIFPHYGPSLAHPWSPEAHPLFFGHPGLERRLLPEAPGPTYPSSQPVWLC LTPRQALGPHPSGEGPSAWSSGNPEGRPCPYPHCQVLPAQPGTEEE-LEELCEQAV------------------------ - >Loxodonta_africana_RNF43 -------------------------------------------------------------------------------- -----------------------MSGGHQLQLAALWPWLLMATLQAGFGR-----------------------------T GLVLAAAVESERSTEQKAIIR-----------VIPLKMDPTGKLNLTLEGVFAGVAEITP--AEGKLMQS--HPLYLCNA SDDDNLEPG-FISIVKLESPRRAPRP-CLSLASKARMAGERGASAVLFDITEDRAAAEQLQQP--LGLTWPVVLIWGNDA EKLMEFVYKNRKAHVRIELK----EPP-AWPD------------------------YDVWILLTVVGTIFVVILASVLRI RCRPHHSRPEPLQQRTAWAISQLATRRYRAS-CKRARAEWPDSGSSCSS------------------------APMCAIC LEEFSEGQELRVISC-LHEFHRTCVDPWLHQHRT----CPLCMFNIVEGD-------------SFSQPLGPSRPYQ---- -------------EPGRRLHLIRQHPGHAHYHFPAAYLLGPSRSSSVVRPPRPGPFLPSQ---EPGS----GPRHHRLPR GAHP--------------RPVGEQQCLAMAQ--LPYAQGWGLSRLR-CTSQH-----------------PA-ACPVP--- -----------------------------PRRARPHDSSGSGESYC---TERSGYLADGPASDSSS------------GP CHGSSSDSVVNCTDISLQGVHGSSSTFRSSLSSDFDPLVYCSPE------------------------------------ -------GEPQKEEPHVSVAS---RPRSLDSVVP-------SGETQVSSHIHYHRHRHHHYKKRF-----QWHGRKAGPE TGHPQSRPGVPRTQLQLEPTSPDEQAARSTSPAPSGQLPSPQRPKAITEPAPGPAEASSPSS----IPSSLLSLQKSSHP ARHPQRKRRGGPSEPTPVSQPQDLTAHPGCRMFPHYGPRLAYPWSPEAHPLIFGPSGLDRRLLPETPAPHYSSSQPVWLC LTPRLPLGPHPPEEGSSEWSPGTTEGRPCPYPHCQVLPAQPGSEEEELEVLCEQAV------------------------ - >Gallus_gallus_RNF43 -------------------------------------------------------------------------------- -----------------------MSGGPQLQLVVLWPWLLMASLQAGLGR-----------------------------T GLALAAAVESERTAVQKAIIR-----------VIPLKVEPI-----VLEGEFASVAEVTP--AEGKLLQS--HPLSLCNT SEDEHTESG-FITIVKLEQPDRDPNP-CLSLANKAKLAGERGARAILFDITDDESAADQLKKP--RGLSQPVVLIRGHDA ELLMGVVNKNREAHVKIEVK----EPP-AWPD------------------------YDVWILLTVVSTVVVIILIFVVRT KCQLNR-TQDSVQQQTMQAIGQLATRRYQAR-CRQAS--WWDSASSCSS------------------------APVCAIC LEEFTEGQELRIISC-SHEFHRECVDPWLQQHHT----CPLCMFNILARD-------------SVDQATVAGSRLAP--- ----------RDMEPGRRLHLFRQHPGHSLYHLPHPYPQRNLRS-FPSEPAHSNPFFHSP---ELS-------------- ------------------------QLLRGQQHPNPPACGQ--PPHRTCSLQP-----------------TP-PCLGLKAA LAQRQHRAPVPR---------------RGVSHGHQHNSSGSGESYL---TEHSGYLADGPGSDSSS------------GP CHGSSSDSVLNCTDISLQGIHGSCSTFRSSLSSDYDPFVYCSSD------------------------------------ -------GPTMDNGPERQRALRETRPRSLDLMVPGGA---APAKAQVLNHIHYHHHQHHHYRRDV-----ECPPGRAGPG PGQRKSRY--SGAKPLESRTELQEAPPVGQPASPQQGREPPHAPSASPNRLDFGVDANRQSGA--AGTSPVLLPQRHSLQ SRH-HRRKRKCPLELDPALLPEDSALP---NHIPHSHP-AGHRCSPEVQP-----------LIPSSPMPCSTGSRPLWKC LVP----------------------------------------------------------------------------- - >Anolis_carolinensis_RNF43 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MTG--------FELTS------------------PPLLIFSQ-- -----------------------------QSN------------------------YDLWILLTVVSTVLVIILIFIVRT RCQPRR-NQAHAQEETLQAINQLATRRYQSR-RRRPGAPNGDSASSCSS------------------------APVCAIC LEEFSEGQELRIITC-FHEFHRCCVDPWLKEHQT----CPLCMFNIVGPP-------------ERPAQRPTNHSRRRAFG GRIRHPFPKTSRFHPQGELLLYCPLVAVLPHSFPRVLLAVLCVGEQNFGAPQKNNHMCRAR--PPSCGDMREASHKDGKN IKNI--------------RASPGQHPCRRPILSLQKQLRLLLTHTKNSKTRHK--------------VIPAGSCPKPGGP PVAGVFGVRSAAGLPLPERQGLLAPAPVRLPPGSPGNPCCQSESCHGAPSEPSGYLPDGPGSDSSS------------GP CHGSSSDSILNCTDVSLTAIHGSCSTFRSSLSSDYDPFAF---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Tetraodon_nigroviridis_RNF43_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSLVNRNEEAIVRINIM----LNPPRWPH------------------------YDVGIVLTIVLAILTIILIFALRY KCRSNR-TWDSVHQQTRQAISRLETKTYNSQGCSGSHRQRAPWGSASSSNS----------------------SPICAIC LEEFQDGQHLRIISC-AHEFHKDCVDPWLLQHRT----CPLCMHNIM--------------------------------- -------------EQSQGFLHHHP-TVAQGTTPSLNMLPFGPGCGYHRPAEG--PGRPHRFGSNCR-----NSAHHYAPR R------------------SCHNYRSSCPAQ---RSASSSRLYHGP-SAGPQ-----------------PR-RAPG---- -------------------------------HSRQGDGSCSGGSYH---TERSGYLADGPASDSSS------------GP CHGSSSDSVLNCTDVSLQGVYGSWSTFRSSLSSDYDPFVYYGPG------------------------------------ -------NGHSAARRSSLDTCAQTRPRSLDSVENKMGCPEEPQPQTVFNHVHYHRHRHHHYEEEE-----HSQGPVRGSD EELG---------------------ATAAAPAALGLDTDSPVTLKHSPCLCPNPEPTDRPSPGT----DCQD-------- ------RDPG-----SPTGLRL---------------------------------------------------------- -------------------------------------------------------------------------------- - >Oryzias_latipes_RNF43_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------QARMALDKGAQAVIFDVSDDANAAAELREA--NSFSRPVVLVEAQGA EDLMGLVNKNEEANVVIEIK----VEP-KWLH------------------------YDVSILLTIILVIFTIVLIFVFRY KCKSNR-TWDSVHQQTVQAINRLETKTYSTQNCSGSQRHRGAWGSASSSNS----------------------SPVCAIC LEEFQDGQHLRIISC-AHEFHKACVDPWLLQHRT----CPLCMHNIMAQ------------------------------- ----------QNSEQSQGFLHSQPYSNPQHHPFPQHAIPFSMRPLYPHGLSGPYPNLGHYSGSSPMD----TQTLHFLSS RQLG--------------AGCGYHHPAEVPG---RPHRTGGSCRTP-THHYT-----------------PR-RSCHNYRS FCPAQ------------------------RTRSRQDEASCSGGSYH---TDRSGYFPDGPASDSSS------------GP CHGSSSDSVLNCTDVSLQGVYGSWSTFRSSLSSDYDPFVYYGPG------------------------------------ -------AGR-LPNTNSPEVSSQVRPRSLDSVVNKAGSPEE-QPQTVS--IHYHRHRHHHYEE----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Takifugu_rubripes_RNF43_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------ARMALDKGAQAVIFDVSDDADAAAELREA--DSLPRPVVMVESDDA EELMALVNKNEEAVVRIEIM----VNPPRWPH------------------------YDMGIVLTIVLAVLTIVLIFALRY KCRSSR-TWDSVHQQTRQAISRLETKTYNSQGCSGPHHQRAPWGSASSSNS----------------------SPVCAIC LEEFQDGQHLRIISC-AHEFHKDCVDPWLLQHRT----CPLCMHNIMALG-------------TSCLWLPPPGTERQAQR ------FRLQQSSEQSQGFLHHHPYSGPRNHHFPQHAVPFSLRPQYPCGPSGPYPDLGHYNGSSPR-----TSSHHYGPR R------------------SCHTYRSSCPAQ---RSASSSRLYHGP-SVGPQ-----------------PR-RTLG---- -------------------------------HGRQGEGSCSGGSYH---TERSGYLADGPASDSSS------------GP CHGSSSDSVLNCTDVSLQGVYGSWSTFRSSLSSDYDPFVYYGPG------------------------------------ -------NGHSAARRSSLDTCAQTRPRSLDSVENKAVCPEEQQPQTVFNHIHYHRHRHHHYEEEE-----HSQSPARGSE EELG---------------------ATAAAPAALSLDKDSPE---HSPCLCPNPDRTG-PAGGP----QHPHPLWSESRF LLPPARAAPGPAACPSSSGLRN---------------------------------------------------------- -------------------------------------------------------------------------------- - >Ciona_intestinalis_RNF43 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------QIHPLSLCNV VGDDQLYEYGWVGVVELGPSYLEPRP-CLSVYGKAKRALEKGATAVIFDITNQPDAVSQLSSEYYERLDRPIVLVQGQSA FHLINLIRDQQVARARIQSGVPTKSEDQYNQY------------------------FNMAVFMGCFVVVFVICIVLLIKL KCWRRE-RSVSMANIASETLRRMKTRKFRVDPRKQWTDDC------SNTS-----------------------EQLCAIC LEVFNENEELRVIPC-SHEFHKHCVDPWLKEKLT----CPLCNFNILGDP-----------------PNLQRRSRQIS-- ------------------SPSVTSRSTIHVTPRRQIFNDYNGYEEGRYENNCPPYESCYTGSRHTNAYYGGHFTELFCDA PNGA----------------QILQNNKFDVVPCVGTVVPHNHYFRRRQPTPH---------------------------- ---------------FYDRSAIPNGASAYQPQRENVGISEFLPKPTNREELSSGSFATPKQLTNFDLPPAYES----LET SRNLPEYCATQTCVTPPYRSIRGCTLYRR-SSGTNTNYRN---------------------------------------- -----------AHNTYMPELDLDSRPVSLRSGYLPDSDGVS--DKVDTTPYLFGPFSVTTTTQCV---------CVVTDT TCCVTDTSVRSVFGSSLISDAPAPPCDS--ILKIPHRSSTPCIGYSSSDAEVGARISVSSLEG--VLESVSVPTVYDDAV NY----------DEIWFDDVMVNDVTSSTSPRLTKHNRAGH--VTTSTNHAADKVTRCAV-------------------- -------------------------------------------------------------------------------- - >Homo_sapiens_RNF128 -------------------------------------------------------------------------------- -------------------MGPPPGAGVSCRGGCGFSRLLAWCFLLALS-----------------------PQAPGSRG AEAVWTAYLNVSWRVPHTG----------VNRTVWELSEEGVYGQDSPLEPVAGVLVPPDG----PGALNACNPHTNFTV PTV-----WGSTVQVSWLALIQRGGG-CTFADKIH-LAYERGASGAVIFNFPG-TRNEVIPMSHPGAVDIVAIMIGNLKG TKILQSI-QRGIQVTMVIEVG-KKHGPWV---------------------------NHYSIFFVSVSFFIITAATVGYFI FYSARR--LRNARAQSRKQ-RQLKADAKKAIGRLQLRTLKQGDKEIGPD------------------------GDSCAVC IELYKPNDLVRILTC-NHIFHKTCVDPWLLEHRT----CPMCKCDILKAL------------------------------ ---------GIEVDVEDGS-VSLQVPVSNEISN----------------SASSHEEDNRS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEA -NSVAVDVIPHVDNPTFEEDETPNQETAVREIKS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Mus_musculus_RNF128 -------------------------------------------------------------------------------- -------------------MGPPPGIGVYCRGGCGAARLLAWCFLLALS-----------------------PHAPGSRG AEAVWTAYLNVSWRVPHTG----------VNRTVWELSEEGVYGQDSPLEPVSGVLVPPDG----PGALNACNPHTNFTV PTV-----WGSTVQVSWLALIQRGGG-CTFADKIH-LASERGASGAVIFNFPG-TRNEVIPMSHPGAGDIVAIMIGNLKG TKILQSI-QRGIQVTMVIEVG-KKHGPWV---------------------------NHYSIFFVSVSFFIITAATVGYFI FYSARR--LRNARAQSRKQ-RQLKADAKKAIGKLQLRTLKQGDKEIGPD------------------------GDSCAVC IELYKPNDLVRILTC-NHIFHKTCVDPWLLEHRT----CPMCKCDILKAL------------------------------ ---------GIEVDVEDGS-VSLQVPVSNEASN----------------TASPHEEDSRS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVQGADEPPLEEHAQSANENLQLVNHEA -NSVAVDVVPHVDNPTFEEDETPDQEAAVREIKS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Pan_troglodytes_RNF128 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------SNTKKPWIALIERGN--CTFSEKIQ-MAYERGASGAVIFNFPG-TRNEVIPMSHPGAVDIVAIMIGNLKG TKILQSI-QRGIQVTMVIEVG-KKHGPWV---------------------------NHYSIFFVSVSFFIITAATVGYFI FYSARR--LRNARAQSRKQ-RQLKADAKKAIGRLQLRTLKQGDKEIGPD------------------------GDSCAVC IELYKPNDLVRILTC-NHIFHKTCVDPWLLEHRT----CPMCKCDILKAL------------------------------ ---------GIEVDVEDGS-VSLQVPVSNEISN----------------SASSHEEDNRS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVQGTDEPPLEEHVQSTNENLQLVNHEA -NSVAVDVIPHVDNPTFEEDETPNQETAVREIKS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gorilla_gorilla_RNF128 -------------------------------------------------------------------------------- -------------------MGPPPRAGVSCRGGCGSSRLLAWCFLLALS-----------------------PQAPGSRG AEAVWTAYLNVSWRVPHTG----------VNRTVWELSEEGVYGQDSPLEPVSGVLVPPDG----PGALNACNPHTNFTV PTV-----WGSTVQVSWLALIQRGGG-CTFADKIH-LAYERGASGAVIFNFPG-TRNEVIPMSHPGAGDIVAIMIGNLKG TKILQSI-QRGIQVTMVIEVG-KKHGPWV---------------------------NHYSIFFVSVSFFIITAATVGYFI FYSARR--LRNARAQSRKQ-RQLKADAKKAIGRLQLRTLKQGDKEIGPD------------------------GDSCAVC IELYKPNDLVRILTC-NHIFHKTCVDPWLLEHRT----CPMCKCDILKAL------------------------------ ---------GIEVDVEDGS-VSLQVPVSNETSN----------------SASSHEEDNRS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVQGADEPPLEEHVQSTNENLQLVNHEA -NSVSVDVVPHVDNPTFEEDETPDQETAVREIKS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Rattus_norvegicus_RNF128 -------------------------------------------------------------------------------- -------------------MGPPPGIGVYCRGGCGAARLLAWCFLLALS-----------------------PHAPGSRG AEAVWTAYLNVSWRVPHPG----------VNRTVWELSEEGVYGQDSPLEPVSGVLVPPDG----PGALNACNPHTNFTV PTV-----WGSTVQVSWLALIQRGGG-CTFADKIH-LAYERGASGAVIFNFPG-TRNEVIPMSHPGAGDIVAIMIGNLKG TKILQSI-QRGIQVTMVIEVG-KKHGPWV---------------------------NHYSIFFVSVSFFIITAATVGYFI FYSARR--LRNARAQSRKQ-RQLKADAKKAIGRLQLRTLKQGDKEIGPD------------------------GDSCAVC IELYKPNDVVRILTC-NHIFHKTCVDPWLLEHRT----CPMCKCDILKAL------------------------------ ---------GIEVDVEDGS-VSLQVPVSNEASN----------------TASPHEEDNRS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVQGADEPPLEEHAQSANENLQLVNHEA -NSVAVDVVPHVDNPTFEEDETPDQEMAVREVKS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Bos_taurus_RNF128 -------------------------------------------------------------------------------- -------------------MGQLPGAGVFCRGGCGFSRLLAWCFLLVLS-----------------------PQTPGSRG AEAVWTAYLNVSWRVPHTG----------VNRTVWELSEEGVYGQDSPLEPVAGVLVPPDG----PGALNACNPHTNFTV PTVPGD--WGSSVQVSWLALIQRGGG-CTFADKIH-LAYERGASGAVIFNFPG-TRNEVIPMSHPGAGDIVAIMIGNLKG TKILQSI-QRGIQVTMVIEVG-KKHGPWV---------------------------NHYSIFFVSVSFFIITAATVGYFI FYSARR--LRNARAQSRKQ-RQLKADAKKAIGRLQLRTLKQGDKEIGPD------------------------GDSCAVC IELYKPNDLVRILTC-NHVFHKTCVDPWLLEHRT----CPMCKCDILKAL------------------------------ ---------GIEVDVEDGS-VSLQVPVSNETSS----------------NASPHEEDNRS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVQGADEPPLEEHAHSANENLQLVNHEA -NSMAVDVVPHVDNPTFEEDESPDQETTVREIKS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Loxodonta_africana_RNF128 -------------------------------------------------------------------------------- -------------------MGPPPATGVSCRGGCGSSRLLAWCFLLALS-----------------------PHAPGCRG AEAVWTAYLNVSWWVPHTG----------VNRTVWELSEEGVYGQDSPLEPVAGVLVPPDG----PGALNACNPHTNFTV PTVPGD--WGNNVQVSWLALIQRGGG-CTFADKIH-LAYERGASGAVIFNFPG-TRNEVIPMSHPGAGDIVAIMIGNLKG TKILQSI-QKGIQVTMVIEVG-KKHGPWV---------------------------NHYSIFFVSVSFFIITAATVGYFI FYSARR--LRNARAQSRKQ-RQLKADAKKAIGRLQLRTLKQGDEEIGPD------------------------GDSCAVC IELYKPNDLVRILTC-NHIFHKTCVDPWLLEHRT----CPMCKCDILKAL------------------------------ ---------GIEVDVEDGS-VSLQVPVSSETSN----------------STSPHEEDNRS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVQGADEPPLEEHVQSANENLQLVNHEA -SSMAVDVVPHVDNPTFEEDETPDQEAAVREIKS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gallus_gallus_RNF128 -------------------------------------------------------------------------------- --------------------------------MKQENKFSPVCFLVIVG-----------------------VLFR---- TTETTAERAFVSLLYFNST----------SNRSASEQCECGLYGLNSPLLSAQGFVAIPK-----AASLQACDWNTQFT- -----------ITEPPWIALIERGN--CTFAEKIK-VAARRGATAAVIYNAPA-KRNYPIPMSHIGAGSIVAIMIGNLKG MEILRRI-ESGLKVTMVIEVG-KKHGPWM---------------------------NHYSIFFVSVSFFIVTAATVGYFI FYSARR--FRITRAQSRKQ-RQLKAEAKKAIGQLQLRTLKQGDKETGPD------------------------GDSCAVC IELYKPNEVVRILTC-NHLFHKNCIDPWLLEHRT----CPMCKCDILKVL------------------------------ ---------GVEVDAEDGA-ESVQATVSSGTSN----------------ITSINEMDSHS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVQGADESVLEEHAPSENDNTHLVNNES -QTSAVTVLPPLDNPTFEADET-----QVSEVRS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Anolis_carolinensis_RNF128 -------------------------------------------------------------------------------- -------MKSFPRGLGGKSVWRTEAAGSGCSCCCRRACAVAGAAFAEVNSAVGDAGVRGGAG----------PGSPPSGG GGLLPYGVVGVAERVVVPG----------RERERERVERGRERPVRAGLASAGAWGRVAVP----EGALEACGAHVNFSG GAAG-------LPEPPWLALVRRGGG-CTFSQKIN-AAALSGAKAAVVFNAPGGQGNEVQVMIHPGTGNTVAIMISYLKG KEILRKM-EQGYQVTMFIEVG-KKHGPWM---------------------------NNYSIFFVSVSFFIVTAATVGYFI FYSARR--LRIARAQNRKQ-RRLKADAKKAISQLQLRTLKQGDKETGPD------------------------ADSCAVC IEVYKPNDVVRILTC-NHLFHKNCIDPWLLEHRT----CPMCKCDILKAL------------------------------ ---------GIEVDIEDGA-ESIQPTEPSNIP-----------------SVP--EEDNHS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVQGADEPVPEEPAHSESDNLQLVNNNA LQPPPVDVLPHLDNPAFEADEAHVQEAKS--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Xenopus_tropicalis_RNF128 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------GTKDTVAIMIGNIKG NEIVEVI-KGGMQVMMVIEVG-RKHGSWI---------------------------NHYSIFFVSVSFFIVTAATVGYFI FYSARR--WRLTRAQNKKM-KQLKAEAKKAIGKLQLRTIKQGDKVMSRDY-----------------------AFGCTLC LRKWAFIIIIILHTCSNHFFHKNCIDPWLLEHRT----CPMCKCDILKSL------------------------------ ---------GIAEDEEETT-SAAIPSVSSELQRS---------------TVQTIEEENRS-------------------- -------------------------------------------------------------------------------- --------------------------------------------ETASSGYASVRGGDEPVDEG---------------- ---------QHI-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Homo_sapiens_RNF130 -------------------------------------------------------------------------------- -----------------------MSCAGR-AGPARLAALALLTCSLWPAR------------------------ADN--A SQEYYTALINVTVQEP------------GRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLP-LHGVADHLGCDPQTRFFV PPNIK----------QWIALLQRGN--CTFKEKIS-RAAFHNAVAVVIYNNK--SKEEPVTMTHPGTGDIIAVMITELRG KDILSYL-EKNISVQMTIAVGTRMPPKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTNARDRNQ-RRLGDAAKKAISKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRILPC-KHVFHKSCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVPNLPCTDNVAFDMERLTRTQAVN-----------RRSALGDLAGDNSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------GLEP-LRTSGISPLPQDGELTPRT-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIR-ATASLNANEVEWF----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Mus_musculus_RNF130 -------------------------------------------------------------------------------- -----------------------MSGAAR-AGPARLAALALLTCSLWPTR------------------------ADN--A SQEYYTALINVTVQEP------------GRGTPLTFRIDRGRYGLDSPKAEVRGQVLAPLP-IHGVADHLGCDPQTRFFV PPNIK----------QWIALLQRGN--CTFKEKIS-RAAFHNAVAVVIYNNK--SKEEPVTMTHPGTGDIIAVMITELRG KDILSYL-EKNISVQMTIAVGTRMPPKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTNARDRNQ-RRLGDAAKKAISKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRVLPC-KHVFHKSCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVPNLPCTDNVAFDMERLTRTQAVN-----------RRAALGDLAGDSSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------GLEP-LRTSGISPLPQDGELTPRT-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIR-ATASLNANEVEWF----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Pan_troglodytes_RNF130 -------------------------------------------------------------------------------- -----------------------MSCAGR-AGPARLAALALLTCSLWPAR------------------------ADN--A SQEYYTALINVTVQEP------------GRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLP-LHGVADHLGCDPQTRFFV PPNIK----------QWIALLQRGN--CTFKEKIS-RAAFHNAVAVVIYNNK--SKEEPVTMTHPGTGDIIAVMITELRG KDILSYL-EKNISVQMTIAVGTRMPPKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTNARDRNQ-RRLGDAAKKAISKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRILPC-KHVFHKSCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVPNLPCTDNVAFDMERLTRTQAVN-----------RRSALGDLAGDNSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------GLEP-LRTSGISPLPQDGELTPRT-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIR-ATASLNANEVEWF----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gorilla_gorilla_RNF130 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ADHLGCDPQTRFFV PPNIK----------QWIALLQRGN--CTFKEKIS-RAAFHNAVAVVIYNNK--SKEEPVTMTHPGTGDIIAVMITELRG KDILSYL-EKNISVQMTIAVGTRMPPKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTNARDRNQ-RRLGDAAKKAISKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRILPC-KHVFHKSCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVPNLPCTDNVAFDMERLTRTQAVN-----------RRSALGDLAGDNSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------GLEP-LRTSGISPLPQDGELTPRT-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIR-ATASLNANEVEWF----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Macaca_mulatta_RNF130 -------------------------------------------------------------------------------- -----------------------------------------XTCSLWPAR------------------------ADN--A SQEYYTALINVTVQEP------------GRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLP-LHG-GEHTGSERERHIFA TVLCG----------HLLALLPRLE--C---KKIS-RAAFHNAVAVVIYNNK--SKEEPVTMTHPGTGDIIAVMITELRG KDILSYL-EKNISVQMTIAVGTRMPPKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTNARDRNQ-RRLGDAAKKAISKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRILPC-KHVFHKSCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVPNLPCTDNVAFDMERLTRTQAVN-----------RRSALGDLAGDNSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------GLEP-LRTSGISPLPQDGELTPRT-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIR-ATASLNANE--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Bos_taurus_RNF130 -------------------------------------------------------------------------------- ------------------------GGEAR-AGPARLAAFALLTCSLWPAR------------------------ADN--A SQEYYTALINVTVQEP------------GRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLP-IHGVADHLGCDPQTRFFV PPNIK----------QWIALLQRGN--CTFKEKIS-RAAFHNAVAVVIYNNK--SKEEPVTMTHPGTGDIIAVMITELRG KDILSYL-EKNISVQMTIAVGTRMPPKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTNARDRNQ-RRLGDAAKKAISKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRILPC-KHVFHKSCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVPNLPCTDNVAFDMERLTRTQAVN-----------RRSALGELASDNSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------GLEP-LRTSGISPLPQDGELTPRT-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIR-ATASLNANEIQWF----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Loxodonta_africana_RNF130 -------------------------------------------------------------------------------- -----------------------MGGAAR-AGPGRLAALALLTCSVWPAR------------------------ADN--A SQEYYTALINVTVQEP------------GRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLP-IHGVADHLGCDPQTRFFV PPNIK----------QWIALLQRGN--CTFKEKIS-RAAFHNAVAVVIYNNK--SKEEPVTMTHPGTGDIIAVMITELRG KDILSYL-EKNISVQMTIAVGARMPPKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTNARDRNQ-RRLGDAAKKAISKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRILPC-KHVFHKSCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVPNLPCTDNVAFDMERLTRTQAVN-----------RRSALSDLASDSSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------GLEP-LRTSGISPLPQDGELTPRT-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIR-ATASLNANE--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gallus_gallus_RNF130 -------------------------------------------------------------------------------- --------------------MGPRWARRRRSGGGSALLLLLGHCWLWAAG------------------------ADDNGS QLSYYTALINVTVLSP------------ERGGPTLLRIDRGRYGQDSPKVEVKGLLVTPVP-INGVADRLGCDPRTRFQV PPNTK----------QWIALLQRGN--CTFREKIL-RAASHNATAVVIYNNI--SSEEPVTMTHQGTGDIVAVMITESKV KEILNYL-EKNISVLMAIAVGSRVPLKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTSARDRNQ-RRLGDAAKKAVGKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRILPC-KHVFHKACVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVPNVPCTENVAFDMERLSRSQPAS-----------RRSALGDFANDSSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------SLEP-LRTSGMSQLPQDGELTPRS-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIK-ATASLNANEAEWY----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Taeniopygia_guttata_RNF130 -------------------------------------------------------------------------------- --------------------------------------LLLWHGRVRPAG------------------------ADN--A SQAYYTALINVTVLSP------------ERGGPTLLRIDRGRYGQDSPKVEVKGLLVAPVP-INGVADRLGCDPRTRFQV PPNTK----------QWIALLQRGN--CTFKEKIL-RAASHNATAVVIYNNV--SSEEPVTMTHQGTGDIVAVMITESKV KEILNYL-EKNISVLMAIAVGSRVPPKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTSARDRNQ-RRLGDAAKKAIGKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRILPC-KHVFHKVCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVPNVPCTDNVAFDMERLTRGQPAS-----------RRSALGDFGTDSSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------SLEP-LRTSGMSQLPQDGELTPRS-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIK-ATASLNANE--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Anolis_carolinensis_RNF130 -------------------------------------------------------------------------------- --------------------------------------LVVLNCYALLAS------------------------ADN--T NQAYYTAFLNVTVLNP------------ERS----AFLIRGRYGQDSPKRGVTGLLLAPLP-INGVVDRLGCDQRTRFQV PPNTK----------QWIALLQRGN--CTFKQKIM-RAALQNASAVVIYNNV--SGEEPVTMTHQGTGDIVTVMITELKV KEILTYL-EKNMSVLIAIAVGTRSQNKNF---------------------------SRSSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTSARDRNQ-RRLGDAAKKAVGKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDVVRILPC-KHVFHKTCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIVTNVPCADNMAFDMERLTRGQLGN-----------RRSVLGDFSSDTSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------TLEP-LRTSGISQFPQDGELTPRT-GEINIAVTKEW FIIASFG-----LLSALTLCYMIIK-ATASLNADEAEWY----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Xenopus_tropicalis_RNF130 -------------------------------------------------------------------------------- ------------------QTGLKMIPRRSLQYLNCLPILVLFPCSMVQSG------------------------SDT--A NMENYSALVNVTIQDP------------SSN-PVLLRIDGGRYGLDSPKTEAKGLLLTPVH-IHGAADRLGCDPQTRFNV PPNTK----------HWIALLQRGN--CTFKEKIL-RAASHNASAVVIYNNN--SKEETVTMTHQGTGEIVAIMISEARG REILSYV-ERNISVLMAIAVGSRNQHKNF---------------------------SRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTSARDRNQ-RRLGDAAKKAIGKLTTRTVKKGDKETDPD------------------------FDHCAVC IESYKQNDIVRVLPC-KHVFHKVCVDPWLSEHCT----CPMCKLNILKAL------------------------------ ---------GIAANVPCTDNVAFDMERLTRSQPPS-----------RRSAPNDPTEEGSL-------------------- -------------------------------------------------------------------------------- --------------------------------------------SLES-LRSSRISQGPHDVEAIPRT-GEINISVTKEW FIIASFG-----LLSALTLCYMIIK-ATASLYATEVEWS----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Danio_rerio_RNF130_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------AVDLQGCCPHTRFIV PPKTT----------HWVAIMQRGK--CTFKEKIL-KAAAFNASAVIIYNNN--TKEDTVTMAHEGTGDIVAVMITESFG KEILGFL-EKNQTVLVSVIVGSRGMPKNI---------------------------NRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRDTSARDRSQ-RRLGDAAKKAISKLTTRTVKRGDKETEPD------------------------FNHCAVC IEGYQLNDVVRILPC-KHVFHKMCVDPWLNEHCT----CPMCKLNILKAL------------------------------ ---------GVMPNLPCVDNMAFDMDRMSRSQTSS-----------QRTALVDLSSETSI-------------------- -------------------------------------------------------------------------------- --------------------------------------------SLEP-LRHSSSSQLPSDEELIPRS-GEINIAVTTGH FFNRNS------VSPRSVVCEMELPDIQASLDMYDDNKS----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Tetraodon_nigroviridis_RNF130_a -------------------------------------------------------------------------------- ---------------------TVGALAAGSRGASMSSLSCSQPSSALAAR------------------------SDRGVV PEEHVGATVNATVLDG------------RGNVVQVMSSVDGRYGQNSPKVDARGVVLTPAP-RNGVVDRQGCDPATRFLV PARTV----------QWVALLQRGN--CTFKEKIL-KAASFNATAVLIYNN---FTEKTVMMGHEGTGDTVAVMITEAFG KELLAHL-DRNLTVLVSVLFR---PTKNI---------------------------NRGSLVFVSISFIVLMIISTAWFI FYFIQK--IGSRSSQHRGQ-RHLGDAAKKAIGKLSTRTVKKGDKETHPD------------------------FNHCAVC IEAYQLNDVVRILPC-KHVFHKVCVDPWLNEHCT----CPICKLNILKAL------------------------------ ---------GITTSVPCVDSVVLDVERLGFAQAS-------------------DSNQPPV-------------------- -------------------------------------------------------------------------------- --------------------------------------------NLDQ-LS-------PPHAEAAPRTPADISIAVTS-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gasterosteus_aculeatus_RNF130_a -------------------------------------------------------------------------------- ------------------------MSPWWTRSSALLVLILVLTRSVAAAR------------------------SDRNIV SEEYVGATVNATVMDG------------RGNVLHMMSSDEGTYGQNSPKVDTRGVVITPAQ-HHGVADRQGCDPGTRFLV PPRNA----------HWVALLQRGN--CTFREKIL-KAAAYNATAVLIYNN---STDKTVKMGHEGTGDTVAVMITEAYG KEILAHL-ERNLTVVVSVVVGQRGPTKNI---------------------------NRGSLVFVSISFIVLMIISSAWLI FYFIQK--IRYTSARDRSQ-RRLGDAAKKAIGKLTTRTVKKGDKETDPD------------------------FNHCAVC IEAYQLNDVVRILPC-KHVFHKVCVDPWLNEHCT----CPMCKLNILKAL------------------------------