>Bos_taurusRAPGEF2(Chromosome_17:_40483943-40580445) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLCSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPAREAPLPFILL GGSEKGFGIFVDSVDSASKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE-- --------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------A TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVVQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT----- --SCANLKTFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLELEMD-EESLQTLSLQCEPATNTLPKNPTDKKPVKSETSPVAPRAGLQPKAQPQPQPPQ--PP--HKLNQGLQVPAV SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRRPAEDTISNTSSQLSSPPTSPQSSPRKGYTLAPSGTVDN FSDSGHSEISSRSSIVSNSSFDSLPVSLPDERRQ--------RPSVSIVETSLASGRLERRPAVEPDQYSLGSCAPLSES RGLYAA-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH FDYPGDAAGLWASSSHMDQIMFPDHSAKYSRQSQSRESLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSLDADS SSMTAVTAEEAKPAAMAAHIAVTP-SAAKGLIARKEGRYREPPPTPPGYVGIPITDFPEAHPHPA-----------RKPP DYTVALQRSRMLARPAEPPAPG----------SARPAPRPQWHRPGDGDPRAGPCAPPGLT-AEEDEDEQVSAV >Bos_taurusRAPGEF3(Chromosome_5:_32697065-32718624) -------------------------------------------------------------------------------- -----------------------------------------------------------------------------MKV GWPGEGRWQVGLAVEGDSIL-----GAPPLGGLPDVVPEGTLLNMVLRRMYRSRSCS--------YQLLLEHQRPSCIQG LRWTPLTSSE----------------------------ESLDFSVSLEQAS-------AERVLRAGKQLHRHLLANCPNL IRDRKYHLRLH-RQCCSGRELVDGILALG-------LGVHSRSQAVGICQVLLDEGALCH--VKHDWAFQDRDTQFYRFP ---GPEPEP---VGVHEL---EEELVEALALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLS------ ---NSVK--RELAAVL---LFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRA ATIILGEDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQG-----------TGPSRPPTPGRNR-YTVMS GTPEKILELLLEAMRPDSSAHDP----TETFLSDFLLTHS---------VFMPTAQLCAALL----------------HH FH-------------AEP----AGGSEQERSSYICNKRQQILRLVSQWVTLYGPTLRTDPVATSFLKK--LSDLVS---R DTRLSNLLREQWPERRRHHRL-----------ENGCGNVSPQMKARNVPVWLPSQDEPLPSSNCAIRVGD---------- ------KVPYDICRP-DHSMLTLQLPVTASVREVMAALAQEDGWT-------KGQVLVKVNSAGDAIGLQPDARGVATSL GLNE-RLFVVNPQEVHELTPHPDQLGP-TVGSAEGLDLVSTKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDV--- --TTANLERFMRRFNELQYWVATELCLCSVPGLRAQLLRKFIKLAAH-LKEQKNLNSFFAIMF-GLSNSAISRLAHTWER LPHKVRKLYSALERLLDPSWNHRVYR--LALTKLSPPLIPFMPLLLK-DMTFIHEGNHTL-VENLINFEKMR----MMAR AARMLHHCRSHSNV-PLSPLRSRVSHLHED------------------------SQAVRVSTCSEQSLSTRSPASTWAYV QQLKVIDN-QRELSRLSRELEP---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Bos_taurus_(Cow)RAPGEF4(Chromosome_2:_23644876-23974945) ----------------------------------------------------------------------------MVAA HA-AHSSS-SAEWIACLDKKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITL---FRQGDIGT NWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAG LLAPPYGVMETGSNNDTFPSKEQT--------PLIEPHVPLRPANTITKVP-------SEKILRAGKILRNAILSRAPHM IRDRKYHLKTY-RQCCVGTELVDWMLQQT-------PCVHSRTQAVGMWQVLVEDSVLNH--VDQEHHFQDK-YLFYRFL ---DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSHLS------ ---TTVK--RELAAVL---IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRA ASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG-----------NRASNQGNSQPQQKYTVMS GTPEKILEHFLETIRLEPALNEAT----DSVLNDFVMMHC---------VFMPNTQLCPALV----------------AH YH-------------AQP----SQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAMAFLEE--FYVSVS---D DARMLAALKEQLPELEKIVKQ------------ISEDAKAPQKKHKVLLQQFNTGDERAQ-KRQPIRGSD---------- ------EVLFKVYCV-DHTYTTIRVPVAASVKEVLSAVADKLGSG-------EGLIIVKMSSGGEKVVLKPNDVSVFTTL TING-RLFACPREQFDSLTPLPEQEGP-TVGTMGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHHFK-K--- --TTANLDLFLRRFNEIQFWVVTEICLCSQPSKRVQLLKKFIKIAAH-CKEYKNLNSFFAIVM-GLSNVAVSRLALTWEK LPSKFKKFYAEFESLMDPSRNHRAYR--LTVAKLDPPLIPFMPLLIK-DMTFTHEGNKTF-IDNLVNFEKMR----MIAN TARTVRYCRSQPFN-PDAAQAN------------------------------------------------KNHQDVRSYV RQLNVIDN-QRTLSQMSHRLEPRRP------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Bos_taurusRAPGEF5(Chromosome_4:_31017033-31222267) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------WGSGPCQTLS-RRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADL IKDRANLKGFY-RRSCVGSELVDWLLEHCP-------FVQCRSMAIGVWQLLLDMGILSS---VDQHLYFQDTYVFYQFS -------SEECSYLYCEFEREEE-WQNGVRLLLQLVPLIPSRAGICELSHQKIEDSEESSDE-----ILARLTSAVQREL AAVI------------------ALKARKSALAQDEENSDKHVTVTEAEA-AADPQAGMMCKLQERDDIGRIELVQKLARE -SCQFLQTDKKEQEKSEHQLK---QDDEVTTVEVKEQDQNVLVLKKVQSC------GPAPQAGS-----AESDWRYVVVS GTPEKILEHLLNDLHLEEVQ----DKETETLLDDFLLTYT---------VFMTTDDLCQALLRI---------------- -------------------YSAKKYQGKEENSDVPCRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKT--IYRNVL---D DVYEYPILEKELKEFQKILGMH---------RRHTVDEYSPQRKNKALFHQFSLKENWLQHRGTVTESEE---------- -------IFCHVYIT-EHSYVSVKATVSSTAQEILRVVAEKIQHAED----DLALVAVTFSGDKEKHELQPNNLAISKSL DASG-RIYVYRKDLADTLNPFAENEES--QQRSIRILGMNTWDLALELMNFDWSLFSSIHEQELIYFTFSRQGSGEH--- ---TANLSLLLQRCNEVQLWVATEILLCSPLGKRVQLVKKFIKIAAH-CKAQRNLNSFFAIVM-GLNTASVSRLSQTWEK IPGKFKKLFSELESLTDPSLNHKAYR--DAFKKMKPPKIPFMPLLLK-DVTFIHEGNKTF-LDNLVNFEKL----HMIAD TVRTLRHCRTNQFGGDISPKEH---------------------------------------------------PELKSYV HHLYVIDS-QQALFELSHRIEPRV-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Bos_taurusRAPGEF6(Chromosome_7:_24107824-24297279) ---------------MGEK-----------------PDGN------------------KQLLLRKIAAQARITPVLQDLN TIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLMKDSMVLPPCSFGKQFGG--KRG CDCLVLEPSEMIVVENSKDNEDNILQREIPARQSRRRFRKINCKGERQTITDDVDINS---------YLSLPADLTKMHI ADNPHPQVTHVSSSQSGCSIASDSGSSSLSDIY--QATESEVGDVDLTRLPEGPVDSEDEEEE-DEDIDRT-DPLQGRDL VRECLEKEPADKTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCSVMIFEVVEQAGAVILE---DGQELDSWYVILNGTV EISHPDGKVDNLFMGNSFGITPTLDKQYMHGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVH------ ----EHRELDRSGTRKGHIVIKGTPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLASPLDVGTKLLEWFKIDSLRDK-VT RIVLLWVNNHFNDFEGDPAMTQFLEEFEKNLEDTKMNGHLRLLNIACAAKAK--------WRQVVLQKASRESPLHFSLS GGSEKGFGIFVESVEPSSKAADAGLKRGDQVMEVNGQNFENITFVKALEILRNNTHLALTVKTNIFVFKELLSRTEQE-- --------------------K-SGVPHIPKIAE-KKSNRHSIQDVPGDLEQTS-QEKGNKKIKANTVSGGRNKIRKIL-D KTR-FSILPPKLFSDGGLSQS---------QDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFS-------N PSD-IPDQVIRVFKADQQSCYIIISKDTTAKEVVCQAIHEFGLTG-ASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRI QLNG-RYYLKNNMETETLCSDEDAQEL-VKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLESKTG---- ---NTHLKEFEDIVNQETFWVASEILTESNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLASVARLRGTWEK LPSKYDKHFQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKK-DMTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRQVVRMTSANMDPAMMFRQRKKRWRSLG-SLSQGSTNSNMLDV-QGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYL SSLDVETD-EEKFQMMSLQWEPAYGTLTKNLNEKKSMKSSEMSPVPLRSAGQTTKAH-------LHQPHRGSQVLQVPAV NLHPIRKKGQGKDPATLST-----GLPQKILGTAEEVSGGKKHTEDTVSVASSLHSSPPVSPQGSPRKGYTLIPSAKSDN LSDSSHSEISSRSSIVSNCSVDSMSTALQDERCS---------SQAVAVPESTGALEKTEHSSGIGDHSQLGPG-WTLSK PSLINKSLAVSSSVSNEEIS---HEHIIIETADSGRGSWTSCSSSSHDNFQSLPNPKGWEF---------------LNSY RPTHLDGPIAEVEPTDC---EHYSCPKGCSRTCGQCKGSLETNQMRQSWASSSSLSDTYEPNYGTVKRRVLENTPAESSE GLDHKEGIDPVYKTVTSSTEKGLIVYCVTSPK--KEDRYREPPPTPPGYMGISLADLKEGP------------HLHLKPP EYSVAVQRSKMMHN-SLSRLPPAS--LSSSPVACVPSKIVIQPQRHKL--------DVTDGDSEADENEQVSAV >Bos_taurusRAPGEFL1(Chromosome_19:_41109870-41122210) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------MKPLEKFLKKQTSQLAGRTVAGGPGGGPGSCGGPGGG------------------- ---------------------------GGPGGGGGPAGGPRPLQRRQSVSRLLLPAFLREPPAEPGLEPPPEEDGGEPTG VAEELGSGGPCWLQLEEVPGPGPLGGGGPLRSPSSYSSDELSPGEPLTPP-------------PWA---------PLGAP ERPEHLLNWVLERLAGGATRDSA---ASDTLLDDIVLTHS---------LFLPTEKFLQELHHEFLQAG----------- ---------------------------GMEGPEGLGRKQACLAMLLHFLDTYQGLLQEE-EGAGRIIKDLYLLIMK---- DESLYQDLREDTLRLHQLVETVEL-------KIPEESQPP-SKQVKPLFRHFHRIDSCLQTRVAFRGSDE---------- -------IFCRVYMP-DHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVASSGEKVLLQPTEDCVFTTL GINS-HLFACTRDSFEALVPLPEEIQV--SPGDTEIHRGEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE--- ---TANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAAI-CKQNQDLLSFYAVVM-GLDNAAVSRLRLTWEK LPGKFKNLFRKFENLTDPCRNHKSYR--EVISKMKPPVIPFVPLILK-DLTFLHEGSKTL-VDGLVNIEKLH----SVAE KVRTVRKYRSQPLCLDMEASPH--------------------------------------------------HLQTKAYV RQFQVIDN-QNLLFELSYKLEANSQ------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Gorilla_gorillaRAPGEF2(Chromosome_4:_169688579-169781068) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE-- --------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------A TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT----- --SCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLELEMD-EESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPP-AHKINQGLQVPAV SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDN FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEG RGLYAT-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH FDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAES SSLTSVTTEETKPVPMPAHIAVAS-STTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP DYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFS-TEEDEDEQVSAV >Gorilla_gorillaRAPGEF3(Chromosome_12:_45650278-45674655) -------------------------------------------------------------------------------- -----------------------------------------------------------------------------MKV GWPGENCWQVGLAVEDSPAL-----GAPRVGALPDVVPEGTLLNMVLRRMHRPRSCS--------YQLLLEHQRPSCIQG LRWTPLTNSE----------------------------ESLDFSESLEQAS-------TERVLRAGRQLHRHLLATCPNL IRDRKYHLRLY-RQCCSGRELVDGILALG-------LGVHSRSQVVGICQVLLDEGALCH--VKHDWAFQDRDAQFYRFP ---GPEPEP---VGTHEM---EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLS------ ---NSVK--RELAAVL---LFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRA ATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQG-----------AGPSRPPTPGRNRRYTVMS GTPEKILELLLEAMGPDSSAHDP----TETFLSDFLLTHR---------VFMPSAQLCAALL----------------HH FH-------------VEP----AGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQK--LSDLVG---R DTRLSNLLREQWPERRRCHRL-----------ENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIRVGD---------- ------KVPYDICRP-DHSVLTLQLPVTASVREVMAALAQEDGWT-------KGQVLVKVNSAGDAIGLQPDARGVATSL GLNE-RLFVVNPQEVHELIPHPDQLGP-TVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDV--- --TTANLERFMRRFNELQYWVATELCLCPVPGSRAQLLRKFIKLAAH-LKEQKNLNSFFAVMF-GLSNSAISRLAHTWER LPHKVRKLYSALERLLDPSWNHRVYR--LALAKLSPPVIPFMPLLLK-DMTFIHEGNHTL-VENLINFEKMR----MMAR AARMLHHCRSHNPV-PLSPLRSRVSHLHED------------------------SQVARISTCSEQSLSTRSPASTWAYV QQLKVIDN-QRELSRLSRELEP---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Gorilla_gorilla_RAPGEF4(Chromosome_2b:_60618923-60937904) ----------------------------------------------------------------------------MVAA HA-AHSSS-SAEWIACLDK-RPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITL---FRQGDIGT NWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAG LLAPPYGVMETGSNNDRIPDKENT--------PLIEPHVPLRPANTITKVP-------SEKILRAGKILRNAILSRAPHM IRDRKYHLKTY-RQCCVGTELVDWMMQQT-------PCVHSRTQAVGMWQVLLEDGVLNH--VDQEHHFQDK-YLFYRFL ---DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLS------ ---TTVK--RELAGVL---IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRA ASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG-----------NRASNQGNSQPQQKYTVMS GTPEKILEHFLETIRLEATLNEAT----DSVLNDFIMMHC---------VFMPNTQLCPALV----------------AH YH-------------AQP----SQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEE--FYVSVS---D DARMIAALKEQLPELEKIVKQ------------ISEDAKAPQKKHKVLLQQFSTGDERAQ-KRQPIRGSD---------- ------EVLFKVYCM-DHTYTTIRVPVATSVKEVISAVADKLGSG-------EGLIIVKMSSGGEKVVLKPNDVSVFTTL TING-RLFACPREQFDSLTPLPEQEGP-TVGTVATFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK-K--- --TTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAH-CKEYKNLNSFFAIVM-GLSNVAVSRLALTWEK LPSKFKKFYAEFESLMDPSRNHRAYR--LTVAKLEPPLIPFMPLLIK-DMTFTHEGNKTF-IDNLVNFEKMR----MIAN TARTVRYYRSQPFN-PDAAQAN------------------------------------------------KNHQDVRSYV RQLNVIDN-QRTLSQMSHRLEPRRP------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Gorilla_gorillaRAPGEF5(Chromosome_7:_22353421-22551715) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------LLEADCDTLS-RRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADL IKDRVNLKGFY-RRSCVGSELVDWLLEHCP-------FVQCRSMAIGVWQLLLDMGIMLS---VDQHLYFQDTYVFYQFS -------SDECSYLYCEFEREEE-WQNGVKLLLQLVPLIPARGGICELSHQKIEDSEESSDE-----ILVRLTSAVQREL AAVI------------------ALKARKSAIEQDEENNDKHVAVTEAES-VPDSQAGVMCKLQERDEIGRIELVQKLAKE -NYQFLQTDKKEQEKSEHQ------DDEVTTVQVKEQDQSVLVLKKVQCC------GPAPTAGS-----AESHWRYVVVS GTPEKILEHLLNDLHLEEVQ----DKETETLLDDFLLTYT---------VFMTTDDLCQALLRMGRHS------------ ----------------ICTYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKT--IYRNVL---D DVYEYPILEKELKEFQKILGMH---------RRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEE---------- -------IFCHVYIT-EHSYVSVKAKVSSIAQEILKVVAEKIQYAEE----DLALVAITFSGDKEKHELQPNDLVISKSL EASG-RIYVYRKDLADTLNPFAENEES--QQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEH--- ---TANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAH-CKAQRNLNSFFAIVM-GLNTASVSRLSQTWEK IPGKFKKLFSELESLTDPSLNHKAYR--DAFKKMKPPKIPFMPLLLK-DVTFIHEGNKTF-LDNLVNFEKL----HMIAD TVRTLRHCRTNQFGSDLSPKEH---------------------------------------------------QELKSYV NHLYVIDS-QQALFELSHRIEPRV-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Gorilla_gorillaRAPGEFL1(Chromosome_5:_43957213-43972993) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------GGPSGGQRSLQRRQSVSRLLLPAFLREPPAEPGLEPPPEE-GGEPAG VAEEPGSGGPCWLQLEEVPGPGPLGGGGPLRSPSSYSSDELSPGEPLTSP-------------PWA---------PLGAP ERPEHLLNRVLERLAGGATRDSA---ASDILLDDIVLTHS---------LFLPTEKFLQELHQYFVRAG----------- ---------------------------GMEGPEGLGRKQACLAMLLHFLDTYQGLLQEE-EGAGHIIKDLYLLIMK---- DESLYQGLREDTLRLHQLVETVEL-------KIPEENQPP-SKQVKPLFRHFRRIDSCLQTRVAFRGSDE---------- -------IFCRVYMP-DHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTAL GINS-HLFACTRDSYEALVPLPEEIQV--SPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE--- ---TANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAAL-CKQNQDLLSFYAVVM-GLDNAAVSRLRLTWEK LPGKFKNLFRKFENLTDPCRNHKSYR--EVISKMKPPVIPFVPLILK-DLTFLHEGSKTL-VDGLVNIEKLH----SVAE KVRTIRKYRSRPLCLDMEASPH--------------------------------------------------HLQTKAYV RQFQVIDN-QNLLFELSYKLEANSQ------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Loxodonta_AfricanaRAPGEF2(SuperContig_scaffold_61_8660295-8758857) -------------------------------------------------------------------------------- -----------------------------------------------------------------------------LRG IFYLEKEAFSTQEMAFLVRCYA-NCLQPWSS--------------------------------------KLPADFTKLHL ADSLHPQVTHVSASHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMKTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFLLL GGSEKGFGIFVDSVDSGSRATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE-- --------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------T TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVVQAIREFAVTT-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT----- --SCANLKTFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNAAVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLELEMD-EDSLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQPQPPSQQQPLP--HKISQGLQVPAV SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKPAEDTVSNASSQLSSPPASPQSSPRKGCTLAPSGTVDN FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERHQ--------RHSVSIVETSLGVGRLERRAVMEPDQYSLGSYAAVSES RGLYAT-ATGISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH FDYSGDPPGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSVEAES SSLAPVPTEEAKPAPVPAHIAAPS-STAKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP DYTVALQRSRMVARSSEVPGPSPVQQPHGHPASSRPVNKPQWHKPNESDPRLAPYQSQGFS-AEEDEDEQVSAV >Loxodonta_AfricanaRAPGEF3(SuperContig_scaffold_2:_33402093-33426994) -------------------------------------------------------------------------------- -----------------------------------------------------------------------------SQV GWPGESRWHLGLAVEASPAL-----GASPAGGLPDVVPEGTLLNMVLRRMHRPRSCS--------YQLLLEHRSPSCIQG LRWTPLTDSE----------------------------ESLDFSVSLEQAS-------TERVLRAGKQLHRHLLATCPNL IRDRKYHLRLY-RQCCSGRELVDGILALG-------LGVHSRSQAVGVCQVLLDEGALSH--VKHDWTFQDRDAQFYRFP ---GLEPEP---VGAHEM---EEELVEAVSLLSQRGPDALLTVALRKPPGQRTDEELDLVIEEVL-IEARGHLF------ ---NSVK--RELAAVL---LFEPHCKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGK---EGLGLED--GQLSSCDGGR-- -----PECVDHWVWL-------VLQDVEAKTMRLEEHGKVVLVLERTSQG-----------AGPSCPPTPGRNR-YTVMS GTPEKILELLLEAMRPDSSAHDP----TETFLSDFLLTHS---------VFMPSTQLCAALL----------------HQ YP-------------PQPQAEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGPVLRTDPVATSFLQK--LSDLVS---Q DARLSNLLKEQWPERRRHHRL-----------ENGYGNASPQMKARNMAVWLAGQDEPLPNSNCAIRAGD---------- ------KVPYDICRP-DHSVLTLQLPVTASVREVMAALAQEDSWT-------KEQVLVKVNSAGDAIGLQPDARGVATSL GLNE-RLFVVNPQEVHKLTPHPEQLGP-TVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRTV--- --TTANLERFMRRFNELQYWVATELCLCPVPGLRAQLLRKFIKLAAH-LKEQKNLNSFFAVMF-GLSNSAVSRLAHTWER LPHKVRKLYSALERLLDPSWNHRVYR--LALTKLSPPVIPFMPLLLK-DMTFIHEGNHTL-VENLINFEKMR----MMAR AVRMLHHCRGHSNV-PLSPLRSRVSHLHED------------------------SQASRISTCSEQSLSTRSPASTWAYV QQLKVIDN-QRELSRLSREMEP---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Loxodonta_AfricanaRAPGEF4(SuperContig_scaffold_3:_54266370-54608199) ----------------------------------------------------------------------------MVAA HA-AHSSS-STEWIACLDK-RPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITL---FRQGDIGT NWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAG LLAPPYGVMETGSNNDRIPDKENT--------PLIEPHVPLRPANTITKVP-------SEKILRAGKILRNVILSRAPHM IRDRKYHLKTY-RQCCVGTELVDWMMQQT-------QCVHSRTQAVGMWQVLLEDGVLNH--VDQEHHFQDK-YLFYRFL ---DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLS------ ---TTVK--RELAGVL---IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRA ASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG-----------NRASNQGNSQSQQKYTVMS GTPEKILEHFLETIRLEPALNEAT----DSVLNDFVMMHC---------VFMPNTQLCPALV----------------AH YH-------------AQP----SQGTEQEKMDYTLNNKKRVIRLVLQWAATYGDLLQEDDVAMAFLEE--FYVSVS---D DARMIAALKEQLPDLEKIVKQ------------ILEEAKAPQKKHKVLLQQFNTGDERAQ-KRQPIRGSD---------- ------EVLFKVYCM-DHTYTTIRVPVAASVKEVISAVADKLGSG-------EGLIIVKMSSGGEKVLLKPNDVSVFTTL TING-RLFACPREQFDSLTPLPEQEGP-TVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK-K--- --TTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAH-CKEYKNLNSFFAIVM-GLSNVAVSRLALTWEK LPSKFKKFYAEFESLMDPSRNHRAYR--LTVAKLEPPLIPFMPLLIK-DMTFTHEGNKTF-TDNLVNFEKMR----MIAN TARTVRYCRSQPFN-PDAAQAN------------------------------------------------KNHQDVRSYV RQLNVIDN-QRTLSQMSHRLEPRRP------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Loxodonta_AfricanaRAPGEF5(SuperContig_scaffold_5:_36306537-36526204) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------TLS-RRISNPYLDHTPSQIYGESSSCAGKALRNIIIVQAADL IKDRVNLKGFY-RRSCVGSELVDWLLEHCP-------FVQCRSMAVGVWQLLLDMGIMLS---VDRHLHFQDTYVFYQFS -------SDECSCLYCEFEREEE-WQNGVKLLLHLVPLIPARSGICELSHQKIEDAEETSDE-----ILARLTSAVQREL AAVI------------------ALKARKSAIEQDEENSDKHIAVPEAEG-VPQSQAGVMCKLQERDDIGRIELVQKLARE -NCQLLQTDKKELEKSEHQ------DDEVTTVQVKEQDQNVLVLKKVPGG------GPAPTSGS-----TENDWRYVVVS GTPEKILEHLLNDLHLEEVQ----DKETETLLDDFLLTYT---------VFMTTDDLCQALLRH---------------- -------------------YSAKKYQGKEENSDVPCRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKT--IYRNVL---D DVYEYPILEKELKEFQKILGMH---------RRHTVDEYSPQRKNKALFHQFSLKENWLQHRGTVTETEE---------- -------IFCHVYIT-EHSYVSVKAKVSTTAQEVLKIVAEKIQHAEE----DLALVAVTFSG--DKHELQPNDFAISKSL EASS-RIYVYRKDLADTLNPFAESEES--QQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEH--- ---TVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAH-CKAQRNLNSFFAIVM-GLNTASVSRLSQTWEK IPGKFKKLFSELESLTDPSLNHKAYR--DAFKKMKPPKIPFMPLLLK-DVTFIHEGNKTF-LDNLVNFEKL----HMIAD TVRTLRHCRTNQFGGDVSPKEH---------------------------------------------------QELKSYV NHLYVIDS-QQALFELSHRIEPRA-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Loxodonta_Africana_(Elephant)RAPGEF6(SuperContig_scaffold_1:_30481100-30734647) ---------------MNSP-----------------VDPG------------------ARQALKKKPPER----TPEDLN TIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQILFCSETIARCWYILLSGSVLMKDSMVLPPCSFGKQFGG--KRG CDCLVLEPSEMIVVENSKGNEESILQREIPARQSRRRFRKINYKGERQTITDDVEINS---------YLSLPADLTKMHL TDNPHPQVTHVSSSQSGCSIASDSGSSSLSDIY--QATESEVGDVDLTRLPEGPVDSEDEEEE-DEEIDRT-DPLQGRDL VRECLEKEPADKTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCSVMIFEVVEQAGAIILE---DGEELDSWYVILNGTV EISHPDGKIENLFMGNSFGITPTLDKQYMHGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVH------ ----EHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDK-VT RIILLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTRMNGHLRLLNIACAAKAK--------WRQVVLQKVSRESPLHFGLN GGSEKGFGIFVEGVEPGSKAADAGLKRGDQIMEVNGQNFENITFVKALEILRNNTHLALTVKTNIFVFKELLSRTEQE-- --------------------K-TGVPHIPRIAE-KKSNRHSIQDVPGDIEQTS-QEKGNKKVKANTVSGGRNKIRKIL-D KTR-FSILPPKLFSDGGLSQS---------QDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFS-------N PSD-IPDQVIRVFKADQQSCYIIISKDTTAKEVVCHAVHEFGLTG-ASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRI QLNG-RYYLKNNMETETLCSDEDAQEL-VKESQLSMLQLSTIEMATQLSMRDFDLFRNIEPTEYIVDLFKLDSKTG---- ---NTHLKEFEDIVNQETFWVASEILTESNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRGTWEK LPNKYEKHFQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKK-DMTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRQVVRMTSANMDPAMMFRQRKKRWRSLG-SLSQGSTNSNMLDV-QGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYL SSLDVETD-EEKFQIMSLQCEPAYGTLTKNLGEKRSAKSSEMSPAPMRSAGQTAKAH-------LHQSHRVSQVLQVPAV NLHPIRKKGQTKDSVTLST-----SLPQKVSGTTEEISG-KKHTEDTISVASSLHSTPPASPQGSPRKGYTLIPPAKSDN LSDSSHSEISSRSSIVSNCSVDSMSAALQDERCS---------SQALAVPESTGALGKTEPPSGIGDHSQLGPG-WTLSK PSLI-KGLAVSSSMSSEEIS---HEHIIIEAADSGRGSWTSCSSSSHDNFQNLPNPKSWDF---------------LNSY RHTHLDGPIAEVEPTDC---DPYSCPVACSRTCGQCRGSLETNQLRQSWASSSSLSDTYEPNYGTVKRRVSENTPAEPSE GLDAKDGTDPMYKTVTSSTEKGLIVYCVTSPK--KDDRYREPPPTPPGYMGISLADLKEGP------------HPHLKPP DYSVAVQRSKMMHN-SLPRLPPAP--LSSSPMACVPSKIVTQPQRHNLQLCHPKLADVTDADSEADEDEQVSAV >Loxodonta_Africana_(Elephant)_RAPGEFL1(SuperContig_scaffold_31:_22204382-22216549) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------MKPLEKFLKKQTSQLAGRTVTGGPGGGPGSYGGPGGG------------------- ---------------------------GGPGGGGGPAGGTAPLQRRQSVSRLLLPAFLREPPAEPGLEPPPEEEGGEPAG VTEEPGSGGPCWLQLEEVSGPGPLGGGGPLRSPSSYSSDELSPGEPLTSP-------------PWA---------PLGAP ERPEHLLIRVLERLTGGATRDSA---ASDILLDDIVLTHS---------LFLPTEKFLQELHQYFVRAG----------- ---------------------------GMEGPEGLGRKQACLAMLLHFLDTYQGLLQEE-EGAGRIIKDLYLLIMK---- DESLYQDLREDTLRLHQLVETVEL-------KIPEESQPP-SKQVKPLFRHFRRIDSCLQTRVAFRGSDE---------- -------IFCRVYMP-DHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVASSGEKVLLQPTEDCVFTTL GINS-HLFACTRDSYEALVPLPEEIQV--SPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE--- ---TANLELLLQRCSEVTHWVATEVLLCESPGKRAQLLKKFIKIAAI-CKQNQDLLSFYAVVM-GLDNAAVSRLRLTWEK LPGKFKNLYRKFENLTDPCRNHKSYR--EVISKMKPPVIPFVPLILK-DLTFLHEGSKTL-VDGLVNIEKLH----SVAE KVRTIRKYRSRPLCLDMEASPH--------------------------------------------------HLQTKAYV RQFQVIDN-QNLLFELSYKLEANSQ------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Monodelphis_domesticaRAPGEF4(Chromosome_4:_183163317-183573962) ----------------------------------------------------------------------------MVAG HA-AHFSS-SAEGIPCRDK-RPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITL---FRQGDIGT NWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAG LLAPPYGVMETSANNDRH-FIFQT--------PLIEPHVPLRPAKTITQVP-------SEKILRAGKILRNAILSRAPHM IRDRKYHLKTY-RQCCVGTELVDWMIQQT-------PCVHSRAQAVGMWQVLLEEGVLNH--VDQEHHFQDK-YLFYRFL ---DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELIHIKALSHLS------ ---TTVK--RELAGVL---IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRA ASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG-----------NRASNQGNSQPQQKYTVMS GTPEKILEHFLETVRLEQPLNEVT----DSVLNDFIMMHC---------VFMPNSQLCPALV----------------AQ YP-------------FIP----SQGTEQDKMDYALNNKRRVIRLVLQWAALYGDLLQEDEVAMAFLEE--FYVSVS---D DSRMIAALKDQLPELEKMVKQ------------ISEDAKAPQKKHKVLLQQFNPVEDRAQ-KRQPVRGSD---------- ------EILFKVYCL-DHTYTTIRVPVSASVKEVISAIADKLGSG-------EGMIIVKMSSGGEKVVLKPNDVSVFTTL TVNG-RLFACPREQFDSLTPLPEQEGP-TTGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK-K--- --TTANLDLFLRRFNEIQFWVVTEICLCAQLSKRVQLLKKFIKIAAH-CKEYKNLNSFFAIVM-GLSNVAVSRLALTWEK LPSKFKKIYAEFESLMDPSRNHRAYR--LTVTKLDPPLIPFMPLLIK-DMTFTHEGNKTF-IDNLVNFEKMR----MIAN TVRTVRYCRSQTFN-PDAALAN------------------------------------------------KNHQDVRGYV RQLNVIDN-QRTLSQMSHRLEPRR-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Monodelphis_domesticaRAPGEF5(Chromosome_8:_301288444-301369787) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------LPT---FDVP--------YFKYI -------DEE--------DEEDE-WSN--------------------RSQSSTED--ESSDS-----LLS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------DRYVVVS GTPEKILEHLLNDLHLEEVQ----DKETETLLDDFLLTYT---------VFMTTDDLCQALPPQHWPHGPAHLFSLT--- ----------------LRTYSAKKYHGREETCDIPRRKRKVLHLVSQWIGLYKDWLHEDEHSKMFLKT--IYRNVL---D DVYEYPVLEKELKELQKMLGLH---------RRHTVDEYSPHRKNKALFHQFSLKENWLQHRGTVGETEEI--------- -------VVCHVSLV-NDSDPNMYVSVRDAAMSTGFLPVSRLCSHS---------VSFDFLK--EKHELQPNDLAISKSL ELSG-RIYVYRKDLSETLSPLVESEES--QQRSLRILGMNTWDLAMELMNFDWSLFNSIHEQELIYFTFSRPGSSEN--- ---TVNLSLLLQRCNEVQLWVATEILLCSQLCKRVQLVKKFIKIAAH-CKAQRNLNSFFAIVM-GLNTASVSRLSQTWEK IPGKFKKLFSELESLTDPSLNHKAYR--DAFKKMKPPKIPFMPLLLK-DVTFIHEGNKTF-LDNLVNFEKL----HMIAD TVRSLRHCRNSHFGGDVSPKEH---------------------------------------------------QELRSYV HHLHVIDN-QQVLFELSHRIEPRA-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Monodelphis_domesticaRAPGEF6(Chromosome_1:_305147164-305246757) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ATESEIGDVDLTGLPEAPVDSEDEEEE-DEDIDRTADPLLGRDL VRECLEKEPADKTDDDI-EQLLEIMHQLPAFAN-MTMSVRRELCSVMIFEVVDQAGAVILA---DGQELDSWYVILNGTV EISYPDGKNESLCMGNSFGIIPTLDKQYMNGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVQ------ ----EHRELDRSGTRKGHIVIKATPERLIMHLIEEHSVVDPTYIEDFLLTYRTFLESPLEVGNKLLEWFKLDSLRDK-VT RVVLLWVNNHFNDFEGDPAMTGFLEEFEKNLEDTKMKGHLRLLNIACAAKAK--------WRQILLQKTSRESPLFFSLS GGSE-GFGIFVEGVEPGSKAAEAGLKRGDQIMEVNGQNFENITLGKALEILKNNTHLSLTIKTNIFVFKELISRTKQE-- --------------------K-NGVPHIPKIAE-KKSNRYSIPDMPGDMEQIFPQEKGNKKIKANTVSGGRNKIRKIL-D KTR-FSILPPKLFSDGSVSQS---------QDDSVLGTRQCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFS-------N PTD-IPDQVIRVFKADQQSCYIIISKDTTAKEVVSHAVHEFSLTG-APETYSLCEVSVSPEGVIKQRRLPDQFSKLADRI QLNG-RYYLKNNMETETLCSDEDAQEL-LRESQITLLQLSTIEVATQLSMRDFELFRNIEPTEYIDDLFKLNSKTG---- ---NTHLKEFEDIINQETFWVASEILTESNQLKRMKIIKHFIKIALH-CRECKNFNSMFAVIS-GLNLAPVARLRGTWEK LPSKYEKHLRDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKK-DITFLHEGNDSK-VDGLVNFEKLR----MIAK EIRQVVRMTSANMDPAVMFRQRKKRWRSLG-SLSQGSTNSNMLDV-QGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYL ANLNVETD-EEKFQIMSLQWEPAYSTLNKNLSERRSTKSSEMSPVPLRSVGQITKAH-------LHQPNRMSQVLQVPAV NLYPIRKKGPTKDHIAFGP-----SASQKIVGMSEEVSG-KKPAEDTLSMASSLHSSPPASPQGSPRKGYAHIPSAKSEN FSDSSHSEISSRSSIVSNCSVDSMSAALQEDRCL---------PQSLSGVDSVGTAEKKENPPVTTDHIQHVAG-WTLPK PSLV-KGLAVPSSVSTEEIS---HDHITIEAVDSGRGSWTSCSSSSHDNFQNIQNQKSWDL---------------LNSY RHTHLDVPIAEVEPTNC---EPYLYAEGYTLTNCQPKDGTEWVQSRQSWASSSSLSDTYETNYGTVKRRVVEDSTVEPDE TLDSHASTDTTYKTVTSSTEKGLIVYCVTSPK--KDDRYREPPPTPPGYMGISLADIKEGPP----------HHPHLKPP DYSVAVQRSKMVHS-NLSRLSSAS--LGSEPMACISSKIPSQPQWHILQPSHPKLAGVTDADSEADENEQVSAV >Monodelphis_domestica_RAPGEFL1(Chromosome_2:_197388286-197399193) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------PTERFLQELYH-FVQSD----------- ---------------------------GIEGAEGLGRKQACLAVLLHFLETYQGLLQEE-ECAGRIIKDLYLLIMK---- DESLYQDLREETLRLHQLVETVEL-------KIPEESQPP-SKQVKPLFRHFRRIDSCLQTRVAFRGSDE---------- -------IFCRVYMP-DHSYVTIRSRLSASVQDILGSVSEKLQYSEESGGREDSLILVAVASSGEKVLLQPSEDCVFTTL GINS-HLFACTRDCYEALVPLPEEIQV--SPGDTEIHRVEPEDIANHLTAFHWELFRCVHELEFVDYVFHGERGRRE--- ---TANLELLLQRCSEVTHWVATEVLLCEPLGKRAQLLKKFIKIAAI-CKQNQDLLSFYAVIM-GLDNAAVSRLRLTWEK LPGKFKNLFRKFENLTDPCRNHKSYR--EVVSKMKPPVIPFVPLILK-DLTFLHEGSKTL-LDGLVNIEKLH----SVAE KVRTIRKYRSRPLCLEMEASPH--------------------------------------------------HLQTKAYV RQFQVIDN-QNLLFELSYKLEANSQ------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Danio_rerioRAPGEF5b(Chromosome_19:_3237686-3265667) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MKT--LYRYVL---E DVYEFPTLEKDLKEFQKLLR-----------RRHTVDDYSPHQKNKALYQQLSLKENSVSLRASPVESRD---------- -------VMCRVYVS-CDSYLSMRVKPAVVAQELLHIVSQRMDRCED----DMMLLAQTYSG--EKRVLQPHDSIYSESL VAPG-RLIACRRDLSEILPPLTECPDL--GQKPVRLLGINTWDVAVALTNFDWNLFNSIHEQELIFYTFSRQASSGH--- ---TVALEFLLQRCNEVQQWVMSEVLLCPSLSKRVQLLKKFIKIAAH-CKAQRNLNSSFAIIM-GLNTAAVSRLNQTWEK VPGKFKKLFSELELLTDPSMNHKAYR--DAFKKMKPPKIPFMPLLLK-DITFIHEGNKTF-HDNLVNFEKL----HMIAD TVRLIRHCQMDQTGNELSAVDS---------------------------------------------------AEVRSSV HYLHIIDN-QQTLFELSHRLEPRV-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Takifugu_rubripesRAPGEF5b(scaffold_45:_363739-385603) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------CAGRSVRNAFLSHGPYP AKDKIHLARII-RRSYVGVELVQWLCEQCV-------YVRCRTTAVRVWQVLLELGVLLS---VDQRVIFSDSNTYYQFS -------FEECDSPSCEFRSNEGEWPEAVRLLLQLAPYVQFRSGGGA--NSPSQSHDSTLTG---IATRAKLVCIVQSEL AAAL------------------ARKTRKALSEQDSETMELSGVCTLRGGGGGGGGGIGTCNREELTSRLGLETVQRLAKD GCRLLQNHNHRLSDKNQAD-------EALGRVCLKERGRDVLVLQRVKSSVTSPSDRPSPTSSGGGSREDDCDKRYVVVS GTPLKILEHLLSDLRLDDQRGAPESRESEMLLDDFLLTYL---------VFMTTHDLCQALLG----------------- ------------------TYSSTRCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKT--LYRCVL---E DLCEFPTLEKDLKEFQKLLR-----------RRHTVDDCPPNQKGKQMYQQLSLKENCVSLRSPAADTRE---------- -------VICCVYVS-ADSYLSVHTHPSLEAHELLRIVSLKLDRAEE----EMVLAVMSNTG--ERRLLQPSDCVYSESL TPQG-KLVACRRDVTEILPPLSDSTEL--SRRPVRLLGINTWDVAAALTHLDWTLFKSIHEQELAYYTLSHPPGAGH--- ---TAALSVLLQRCNEVQQWVMSEVLMCVSLNKRVQLLKKFIKIAAH-CKAQRNLNSAFAIIM-GLNTAAVSRLNQTWEK CPGKFKKLFSELELITDPSLNHKAYR--EAFKKMKPPKIPFMPLLLK-DITFIHEGNKTF-HDNLVNFEKLLNPQHMIAD AVRMIRHCQSDQPGNEVIGVDS---------------------------------------------------AEVRGSV QYLHIIDN-QQTLFELSHKLEPRA-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Gasterosteus_aculeatusRASGEF5b(groupX:_8815409-8840688) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------RRSYVGVELVQWLCEQCV-------YVRCRTTGVRVWQVLLELGVLLS---VDQRVMFSDSNSYYQFS -------FEECDSASCDFRSNEGEWPEAVRLLLQLAPYIQFRSGGGA--NSPHPRSEEDSEGNRDICSEMLQIQQVQNEL AAAL------------------ARKTRKALSEQDSESTDTSQQEPQTPSEESSPGTGTVCGREELTGRLGLEAVQRLAKD GCRLLQNHNYRVPDRTQADN------EAVGRVCLKERGRDVLVLRRVTSSVTSPSDRPSPTSSGGGSREEDCDKRYVVVS GTPLKILEHLLSDLRLDDQRGAPECRESETLLDDFLLTYL---------VFMSTNDLCQALLG----------------- ------------------QYPSDRCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKT--LYRCVL---E DLYEFPTLEKDLKEFQKLLR-----------RRHTVDDCPPNQKSKQMYQQLSLKENCLQLRSPPSETKE---------- -------VICCVHVS-ADSYLSVHTHHSLEGHELLRIVGQKMDRAEE----DMVLAVASHTG--ERRVLQPSDCVYSESM TPQG-KLVACRRDLTEILPPLTDSAEL--SRRPVRLLGINTCDVAAALTHLDWSLFKSIHEQELAYYTLSRVPGTGH--- ---TAALSVLLQRCNEVQQWVMSEVLMCTSLNKRVQLLKKFIKIAAH-CKAQRNLNSAFAIIM-GLNTAAVSRLNQTWEK CPGKFKKLFSELELITDPSLNHKAYR--EAFKKMKPPKIPFMPLLLK-DITFIHEGNKTF-HDNLVNFEKL----HMIAE TVRMIRHCQSDQPGNEVIGVDS---------------------------------------------------AEVRASV HYLHIIDN-QQTLFELSHKLEPRA-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Oryzias_latipesRAPGEF5b(Chromosome_11:_8720895-8734390) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------TSM LATL------------------AEAE-EDEDEADSEDEDGTN-----------------------SDTFDVPHLRYIDDD ------------SKEEEKEG------SWVDTDCWN-------------------------SSS----------YRYVVVS GTPLKILEHLLSDLRLDDQRGAQENRESEMLLDDFLLTYL---------VFMSTHDLCQALLV----------------- ------------------TYGGARCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKT--LYRCVL---E DLYEFPSLEKDLKEFQKLLR-----------RRHTVDDCPPNQKSKQMHQQLSLKENYLHLRTPQTEHKE---------- -------VMCCVYVS-ADSYLSVHTHPSLEAHELLRIVGMKMDRAEE----DMVLAVVSHTG--ERRVLQPSDCVYSESL TPNG-KLVACRRDLNEVLPPLADSAEL--NKRPVRLLGINTWDVATALTHLDWTLFKSIHEQELVYYTLSRPPGSGH--- ---TAALSLLLQRCNEVQQWVMSEVLMCVSLNKRVQLLKKFIKIAAH-CKAQRNLNSAFAIIM-GLNTAAVSRLNQTWEK CPGKFKKLFSELELITDPSLNHKAYR--EAFKRMKPPKIPFMPLLLK-DITFIHEGNKTF-HDNLVNFEKL----HMIAD TVRNIRHCQSDQAGNEVIGVDS---------------------------------------------------ADVRASV HCLHIIDN-QQTLFKLSHKLEPRA-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Homo_sapiensRAPGEF2(Chromosome_4:_160025330-160281321) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE-- --------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------A TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT----- --SCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLELEMD-EESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPP-AHKINQGLQVPAV SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDN FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEG RGLYAT-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH FDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAES SSLTSVTTEETKPVPMPAHIAVAS-STTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP DYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFS-TEEDEDEQVSAV >Mus_musculusRAPGEF2(Chromosome_3:_79062516-79144977) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MKPLAAPANHG-VLGQQEKQ--------------------------------------SLPADFTKLHL TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL GGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE-- --------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFS-------T TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT----- --SCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK LPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLELEMD-EESLQTLSLQCEPATSTLPKNPGDKKPVKSETSPVAPRAGPQQKVQPQ-QPLAQPQP-PHKVSQGLQVPAV SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDN FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSES RGLYAA-ATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH FDYSGDAASIWASGGHMDQMMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSAEAES SSMVPVTTEEAKPVPMPAHIAVTP-STTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPA-----------RKPP DYNVALQRSRMVARPTEAPAPG---QTPPAAAASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV >Macaca_mulatta_(Macaque)RAPGEF2(Chromosome_5:_151436894-151529507) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE-- --------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------T TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT----- --SCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLELEMD-EESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLLQPQQQPPP-AHKINQGLQVPAV SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDN FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVETNLGVGRMERRTMMEPDQYSLGSYAPMSEG RGLYAT-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH FDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAES SSITSVTTEETKSVPMPAHIAVAS-STTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP DYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFS-TEEDEDEQVSAV >Pan_troglodytesRAPGEF2(Chromosome_4:_162372821-162464849) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE-- --------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------A TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT----- --SCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLELEMD-EESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPP-AHKINQGLQVPAV SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDN FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEG RGLYAT-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH FDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAES SSLTSVTTEETKPVPMPAHIAVAS-STTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP DYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFS-TEEDEDEQVSAV >Rattus_norvegicuRAPGEF2(Chromosome_2:_170472420-170522450) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------S--------------------------------------QLPADFTKLHL TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRSMTLTKPSREAPLPFILL GGSEKGFGIFVDSVDSSSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE-- --------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFS-------T TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT----- --SCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK LPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLELEMD-EESLQTLSLQCEPATSTLPKNPADRKPVKSETSPVAPRAGPQQKAQPQ-QPLAPPQP-SHKVSQGLQVPAV SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDN FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSES RGLYAA-ATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH FDYSGDATGIWASGGHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSTEAES SSMVPVTTEEAKPVPMPAHIAVTP-STTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPA-----------RKPP DYNVALQRSRMVARPTEAPAPG---QTPPAATASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV >Taeniopygia_guttataRAPGEF2(Chromosome_4:_30007643-30049672) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------LPADFTKLHL TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLITLTKPSREAPLPFILL GGSEKGFGIFVDSVDFGSKATEAGLKRGDQILEVNGQNFENIQLTKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE-- --------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPPALPVSGTLSSSNPDLLQSHHRILDFN-------T TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFALTA-TPDAYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT----- --GCTNLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK LPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VEGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSANAAVLDVAQAGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLDLEMD-EESLQTLSLQCEPATNTLPKNTGDKRSGKSETSPVAPRAGIQQKVQQQ-----------HKVNQALQVPAV SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLDRHKKQSEDTVSSASSQLSSPPTSPQSSPRKGYTLAPSSTVDN FSDSGHSEISSRSSIVSNSSFDSMPVPLHDERRQ--------RHSVSIVETNLGVGRIDRRIMIEPDQYSLGSYAPLSET RGLYAG-ATVLSSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHAH FDSSGDGAGLWASGGHMDQLMFPDHGTKYGRQSQGREGLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEADT SSITSVPAEETKPAPVPPHTAAAS-SSTKGLVARKEGRYREPPPTPPGYVGIPIAEFAEGGSHPA-----------RKPP DYNIALQRSRMVARTCETHGTATPQQQSHGHSTGRPVNKPQWHKPNESDPRLAHYPSQGFS-TEEDDTEQITQI >Xenopus_tropicalisRAPGEF2(Scaffold_GL172746.1:_939170-1044459) ----------------------------------------------------------------------------QDLE IVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRG CECIVLEPSEMIVVDYMDENEE-YFQRQASHRQSRRRFRKINQKGERQTIIDTVESYPVGKPPLPRGYHTLPADFTKLHI TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQ-QATESEPGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTVVLN---DGEELDSWSVILNGSV EVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLITLTKPSREAPLPFNLL GGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALEILRNNTHLSLTVKTNLFVFKELLARMLEE-- --------------------KRNSAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVSKKGKANTVGG-RNKLKKIL-D KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHMPATLPVSGTLSSSNPDLLQSHHRILDFN-------T TPAEQPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFALTA-VPDAYSLCEVSVTPEGVIKQRRLPDQLSKLADRI QLSG-RYYLKNNMETETLCSDEDAQDL-LRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLFKLKMKT----- --GCTNLKNFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVSRLRTTWEK LPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMASVNMDPALMFRTSGKVLLSLKRSLSQGSTNATVLDVAQSGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SDLDLEMD-EENLQTLSVQCEPATNTLPKNPCEKRAGKPDTSPVAPRAAAQHKQQQQQQ---------TKVNQALQVPAV ALYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQCSPRKGYTMAASGTVDN FSDSGHSEISSRSSIVSNSSFDCV--HLHDDRRQ--------RHSLSIVETNLGVGRADRRAIIDADQCSLGSYAPVAET RGLYAG-ATVLSSPSMEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIPHQRSWET------------LPFGHVH FDNTADGSGFWATGGHMDHGIFPDHSTKYGRYSQGREPLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVALEAET SSITSMTPEETKPLPVPTHVAVTA-SSAKGLIARKEGRYREPPPTPPGYVGIPIADFADGHPPLS-----------RKPP DYNVALQRSRMMARRSESEGSAATSPPSHNQTSGRTANKPQWHKPNEADPRLALYQAQGVTEKDDADDEQVSAV >Danio_rerioRAPGEF2(Chromosome_14:_50716244-50966935) ------------------------------------------------------MASYVDNSFRQAVMVNPSDRTQQDLE IVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRG CECIVLEPSEMIVVDYMDENEE-YFQRQASHRQSRRRFRKINQKGERQTIIDTVDPYPAGKPPVARGYHTLPADFSRLHL ADGIHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEPGDMDLSGLPETAVDSEEDDDE--EDIERASDPLMSRDI VRDCLEKDPMDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTHPDSRNEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFHDPSLRDK-VT RVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAK--------LRVVTLTKPSREAPLAFTLL GGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVKTNLLVFKELLARPDQDQE QEQ------------EEEPDRKNGAPHIPKIGDIKKASRYSIPDLAVDVEQVMDLEKASKKAKANSAGG-RNKLKKIF-D KTL-TSILPPKPYNDVGVGQS---------QDDSIVGLKQSKQIPPALPVSGNLSSSNPDLLQSHHRILDFN-------N QP-DMSDQVLRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTA-AAEAYSLCEVSVTPEGVIKQRRLPEQLSKLADRI QLSG-RYYLKSNMETETLCSDEDAQEL-LRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKLKTRLT---- --GPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVSRLRGTWEK LPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK EIRHVGRMAAVNMDPALMFRTRKKKWRSLG-SLSQGSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL SNLTLETN-EESLQTLSMQCEPSINTLPKSSGDR--KRPDTSPVVSRAATHQRQQLQ------------KANQALQVPAV ALYPSRKKVPVKDLPPFGTSSPQSLKKILSLSEEAG-DRHRKQAEDSVSNNSSQLSSPPTSPHSSPKKGYGRAG----DY LSDSGHSEISSRSSLVSTSSLDMG----QDERRQ--------RYGGTAGEGHGSGHRLERRATADPDQYSLGSYSSMQDC RGLYAG-ATVLSSPSSEELTQDQGDRVSLDAADSGRGSWTSCSSGSHDNIQTMQQGRSWEA------------LAEGAG- ---------------------------LWGS--RGSWASACSSS-----SSVACWGEDSEGDTGTIKRRGGRDVTTDPET SSITSTGSEESRQHSRRPSPITAG--NTKASITRKDGRYRDPPPTPPGYTALTITDVTEGTP-----------HSGRKPP DYTTALQRSRLVTHSLDSQQPPAAGKPDPRGREEDEAVEVEEEGECLSPKLRAQRRRGPHTAVPPRP------- >Takifugu_rubripesRAPGEF2(scaffold_70:_21546-63207) ---------------------------------------------------------------------------SQDLE IVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRG CECIVLEPSEMIVVDYMDENEE-YFQRQASHRQSRRRFRKINQKGERQTIIDTVDPYPAGKPPIARGYHTLPADFSRLHL ADGLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATENEPGDMDLSGLPETAVDSEEDDDE--EDIERSSDPLMSRDI VRDCLEKDPMDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV EVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVK------ ----EHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPSLRDK-V