>Homo_sapiens_NACAD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MPGEAARAELLLPEADRP---------- -------------------------------------------------------------------------------- ----------GPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGE GGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPP DPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFP SGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTP LSPEEEEEEA----------VADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAE ADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQE STATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLC PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQ DSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQ DSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQ DSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT EPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAG EEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALG-GAREVPDAPPAACPEVSQA RLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEV PSVLGTPLLQPPENLAKGQPSTPVDRPLGPDP--SAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQA GVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSL EEDSPRALGSGQ-------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------HSDSHGESSAELDEQDILAPQT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------VQCPAQAPAGGSEETIAKAKQSRSEKKARKAM SKLGLRQIQGVTRITIQKSK---NILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESA PRPRVRLECKEEEEE-----EEEEVDEAGLELRDIELVMAQANVSRAK-------AVRALRDNHSDIVNAIMELTM---- --- >Mus-Muculus_NACAD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------MSALPLALRSARRAGA RSLGLIGGRGSADVIYAPPPPSRGAVAVLATPSALTDRGTERQGYRQAHVQAMPGEAAGAELPLPEAGGP---------- -------------------------------------------------------------------------------- ----------GSRTDHSCDAAIAT-ILKGDQLEPHGLTPGPSPLALTFLSSKPGARPQPEGASWDAGPSGAASAWVDPAE GSPSLVVLPEGLPLRPVPAEGPLPTTLEPRIVMGEETCQVIASPRAAWPVLRDREGGHPALHPPPELCSQGDPPVPSPPP DLESYFTPPSTPTKSTHALLPDHGPHRDAWDLEAELLDELLDSTPASPSGSYITADGDSWASSPSCSLSLLDPAEGLDFP SDWGLSPSGSVADDLEPHPAAPPEPPSSESSLSADSSSSWSQEGHFFDPNFLANDPMIPAALLPFRGSLIFQVEAVEVTP LPQEEEEDEEDVAATAAAAAPAAATPDGDLAGEGEDDSTSASFLQSLSDLSIIEGMDEAFAFRDDTSAASSDSDSASYAG ADDDRLYSGEPHAQP-----SAQNTEQAYR--------SRATFPG-IESTPQTSEQEICLTNSQESVAEIAEEILTLGLE SEAMRTPPDQQAAPGPQVEETPTVTPWVGNK-VDLVV--EQVSKALPEPCQEGISTTLGCKPLTAEAIPDLQEGASPSLC PVLPE-KKEEG-QGLPSTLEYVAVALEGPWKAEGGVTIPQDPLMTLPPLLQSTVPTSGPESVAVVALEPQQNEGCVTVLP DVPVVLPPSPQSVDPSSGPEAMAVATYEFQRAKEGTPGLQD--------------------------------------- ----------------------------------------------------SPVAASP--------------------- --------ALQGPDPTSEPEPEVVVTSRSQQDEGIVTVPQESPTASSLTLQSSHPTSDQEREVAATLGPQQAEEGVTIPQ VAPVASPSLLQGLESTSDLESVVVGTPESQQDEGIATATQDTPVMAPPPLRGTDSTSDPELIAPDTSQALQREAGHTPGT KPSVSEAHQELGVASGPRPVPKEGDAEPPPHSAPPASNQAQQNGSEPGYKSDSFGAPEE-SDSTLSTKTS---EPTSCMG EKVAANMSAPKQGACLEA----HDGVKTHSPQREALRSKNKRGRGTKSPGQGNGPKSATSQGAVETCRAHSAARSEVSQP QLR---------SNEDTSGPRLPVAVSVQARLGSCPGSPARATCTLSRVYAEETS-RCAPPFQHLEPMLGLGSAEQPKVT PGILN----LSPDNSAGDLLTTSQNRFLDPDP---APSTLDRASQSSPGPPDPCLCPPPQKASEEEEKPPASRGPMPRAG AQGAAAITTSGSTKPPGARQRVSLSPHST-LNPKVAPTDTKDLACIISSPCQVPPPSGTQNPSGPREFPALEQ-KDEDSL EEDAQRAPGSGQRWESHGESSSELDEYLAPPPDAQR-------------------------------------------- -------------------------------------------------------------------------------- ---------------------TPGSGQRSESHGESSSELGEQD-LSPQK------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------SQCPAQGPAGSNEETIAKAKQSRSEKKARKAM SKLGLRQIQGVTRITIQKSK---NILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPELS PGPRVRPECEEQEEE-----DEE-VEEAGLEPRDIELVMAQANVTRAK-------AVRALKDNHSDIVNAIMELTM---- --- >Pan_troglodytes_NACAD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MPGEAARAELLLPEADRP---------- -------------------------------------------------------------------------------- ----------GPRTDLSCDAAAATTILGGDRRDPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGE GGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDREGGHTSPDPPPELCSQGDLSVPSPPP DPDSFFTPPSTPTKTTYALLPGCGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFP SGWGLSPRGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTP LSPEEEEEEA----------VADPDAGGDLAGEGE-DSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAE ADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQEGTVSWALEAAPQTSDRGAYLSQRQESISEVTEEGLALGQE STATVTPHTLQVAPGLQVEAATRVTPQAGEEEADSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLC PDSPQNLKEEG-LDLPSGGKPVAAATIVPRQAEEDLTLPQDSAMTLPLPLQDTDLSSAPKPVAAATLVPQQAEEGLTLPQ DSAMTPPLPLQDTDLSSAPKPVAVATLVPQQAEEGLTLPQDSAMTP---------------------------------- ------PLPLQDTDLSSAPKPVAAATLVPQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAVATLVPQQAEEGLTLPQ DSAMTPPLPLQDTDLSSAPKPVAAATLVPQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPLAAATLVPQQAEEGLTLPQ DSAMTPPLPLQDTDLSSAPKPVAAATLVPQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQSWQAEAGCAPGT EPVATMAQQEVGAALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAG EEIAEALSRPGREACLEVRAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALG-GAGEVPEAPPAACPEVSQA RLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVARLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEV LSVLGTPLLQPPVNLAKGQPSTPTDRPLGPDP--SAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQA GAQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSL EEDSPRALGSGQ-------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------HSDSHGESSAELDEQDILAPQT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------VQCPAQASAGGSEETIAKAKQSRSEKKARKAM SKLGLRQIQGVTRITIQKSK---NILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKMPSEPSALVPESA PRPRVRLECKEEEEE-----EEE-VDEAGLELRDIELVMAQANVSRAK-------AVRALRDNHSDIVNAIMELTM---- --- >Gorilla_gorilla_NACAD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MPGEAARAELLLPEADRP---------- -------------------------------------------------------------------------------- ----------GPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGE GGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDREGGHASPDPPPELCSQGDLSVPSPPP DPDSFFTPPSTPTKTTYALLPGCGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFP SGWGLSPRGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTP LSPEEEEEEA----------VADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAE ADDERLYSGEPHAQATLLQDSVQKTEEESRGGAKGLQAQEGTVSWALEAAPQTSDRGAYLSQRQELISEVTEEGLALGQE STATVTPHTLQVAPGLQVEVATRVTPQAGEEEADSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLILC PDSPQNLKEEGGLDLPSGGKPVAAAMIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQEAEEGLTLPQ DSATTPPLPLQDTDLSSAPKPVAAATLVPQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQEAEEGLTLPQ DSATTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSATTPPLPLQDTDLSSAPKPVAAATLVPQQAEEGLTLPQ DSAMTPPLPLQDTDLSSAPKPVAAATLVPQEAEEGLTLPQDSATTPPLPLQDTDLSSAPKPVAAATLVPQQAEEGLTLPQ DSAMTPPLPLQDTDLSSAPKPVAAATLVPQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGWAPGT EPVATMAQQEVGAALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPATEAGTPWAAQEDADSTLGMEALSLPEPASGAG EEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALG-GAGEVPEAPPAACPEVSQA RLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSRLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHKV PSVLGTPLLQPPENLAKGQPSTPADRLLGPDP--SAPGTLAEAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQA GAQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSL EEDSPRALGSGQ-------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------HSDSHGESSAELDEQDILAPQT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------VQCPAQAPAGGSEETIAKAKQSRSEKKARKAM SKLGLRQIQGVTRITIQKSK---NILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESA PRPRVRLECKEEEEE-----EEEEVDEAGLELRDIELVMAQANVSRAK-------AVRALRDNHSDIVNAIM-------- --- >Rattus_norvegicus_NACAD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MPGEAAGAELPLPEAGGS---------- -------------------------------------------------------------------------------- ----------GSRTDLPCDAAIAT-ILKGDQREPHGLTPGPSPLALTFLSSKPGARPQPEGASWDAGPSGAASTWVDPAE GSPSLVVLPEGLPLRPVPADVPLPTTLEPRIVMGEETCQVLPSPRAAWPVLRDREGGHTALHPPPELCSQGDPPVPSPPP DLDSYFTPPSTPTKTTYALLPDHGPHRGAWGLEAELLDELLDSTPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFP SEWGLSPSGSVVDELEPHPTAPPEPPSSESSLSADCSSSWSQEGHFFDPNCLANDPMIPAALLPFRGSLIFQVEAVEVTP LPQEEEEDEE---EGAAAAAAAAATPDGDLAGEGEDDSTSASFLQSLSDLSIIEGMDEAFAFRDDTSAASSDSDSASYAG ADDDRLYSGEPHAQP-----SAQNIEQEYR--------SRTAFPGAAEFTPQTSEQEICLTDSQESAAEIAEEILTLGIE SEATRTPPDRQTAPDPQVEEATTVTPWVENK-DDSVA--EQASKALPEPCQKGTSMILGCKPLTAKAIPDLQEGAGPAMC PVLPENLKEGG-QGLPSTMEYVAVASVGPWKAEGGVAIPQDPFMTLPPLLQNTDPTSGPESVAVVMLEPQQDEGCVTVLQ DVPVVSLPSPQSTDPTPGPEAGAMATFEFQQAKEGVPELQD--------------------------------------- ----------------------------------------------------TPVASSP--------------------- --------ALQASDPTSEPEPEAVLTLRSQQDEEIVTVPQESPTASSVPLQSSDPTSEPEPEAAATPEPQQPEEGVTIPQ VAPVALPSPLQGLDSTSDLESVVAGTMESWQDEGIATATQDMPVVAPPPLGGIESTSDPELSAQDTPQALQREAGYTPGT KPSVSEAHQELGVALGPRPVPKEQDAKPP-HSELPASDQAQQNGSEPVVKNDNLGVPGEGSGPTLSTKTS---EPLSCMG EKVTENLAAPKPGACLEA----HDGAKTHSPQRQASRAKNKCGRGPKPPGQGKGSKSTASQGTTETFKAHSAARSETSQP QLMNSAGEGTSLSVKDSSGPRLPVAVSVQSKLGSCPGSPARATCTLSRVYSEETA-RCAPPFQHPEPVLGLGSGEQPKVT LGTLN----LSSENSAGDLLTTPQNRLLDPDPDPSAPSALNRAFQSSPGPPDPCLCPTSQKDPVEEEKPSASHGLRSRAG VQGAAAITTSGSTKPLGARQRVSLSPHS--ANPKVTPTDAKDPACIISSPCQVPPPSGTQNPSGPRGFPAHEQ-EDEDSL EEDSQRAPGSGQ-------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------HSESHGESSGELDEQD-ISPQK------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------SQCPAQDPAGSNEETTAKAKQSRSEKKARKAM SKLGLRQIQGVTRITIQKSK---NILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSESSALVPELA PGPRVRPECEEQEEE-----EEE-VEEAGLEPRDIELVMAQANVSRAK-------AVRALKDNHSDIVNAIMELTM---- --- >Bos_taurus_NACAD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PSVSTDLSCDAAEATTPKGDRLEHCALTSGPSTLALTFLHGKPGARPPPEGASWDAGPGRAPSAWTVQAE GGPSPGPA------EVRPTEGPLPASLEPRIVMGEETCQAAPLPRATMPELRDWEGGHANLNPPPEFCSQGDPPVPFPAP DSDSYFTPPSTPTKTASTLLPGPGPHRDA----QDAQAELGDSPPASPTGSYITADGDSWASSPSCSLSLQALAEGLDVP SGWGFSPSGSVVDERELPPAGTPDSSSPESSLSADSSSSWGQEGHFFELDFLANDPMIPAYLLPFQGSLIFQVEAVEVTP LPHEEEEVEE----EEQEEEQEVPLPRGDLAGEGEDDSTFASSLQSLSDLSITEGVDEAFAFRDDTSAASSDPDSASYTG ADDERLYSGEPHAQPATLLQDSPGEAASWGPEPSSTPQDAGLPLVQGSASEASPESQSEEDLTASSTPQDAGLPLVQESA SEVSPEPQSEEDLTASLPLKDESLPLVQGSASEASPEPQSEDLTASLPLKDEGLPLVQGSASEASPEPQSEEDLTASPPL QDTDLPLVQGSVSEASPEPQSEEDLTASPPLQDAGLPLVQGSVSEVSPEPQSEEEDLTASPPLQDAGLPLVQGSASEASP DHQSDLKASPPLQDAGLPLVHGPASEASPEPQSEEEELTAS--------------------------------------- -------------------------------------------------------------------------------- ----------------------------LPLQDTGLHLVQGSAFKASPELQSEEEGSVSEASTEPQSEEEELTASLHLQD TGFSLVQGSASDASSEPQSEEEELTASSHLQDAGLPLVHGSASEASPELHQVSATSASPQALMTDTGCTQKTEPTTTAAH RKGRKTLGLRPAPEERDPDHTGGSDSLALDQIHLGGPDLPADARTPLEGDAGPSKPATEIPDTPSGEEVAEG-----IL- ---------------------------APEQEACHDICAHGGDGAESSSPPKVALGVEHQGHEALKPVVHGPGVCPTASL EVGQLGPPSPVEEGRATLGHRLPMAVGSEAGLGSCSQSPSRAVPRLGGHCAKDPAPTSPLPLRQPKPVLGPGKGERAQAA LGVLGPSPLQPPESPIGGLPSAPQDRIQGPEPPAPGILMEAVPTPLASPAPCPCRGPREDLVEGAEPLGSPSHPPPRPRA QRAVAASSGITNPPGAGQVSLPPHPTLLSPKAAPKRGTHAKDPASRLSPPRQVPPGSGPRSPAGPRGLPATEQQDDGDSL EEGGQRAGQGCQSCSPRAPVQKGRPSSHSPSSDSPR-------------------------------------------- -------------------------------------------------------------------------------- ---------------------ALGSGQHSDSHGESSAELEEQDLPGPQT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------AQCPAQAPAGSGSEETVAKAKQSRSEKKARKAM SKLGLRQIQGVTRITIQKSK---NILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHRAAAEKFKVPSEPSALVPESA PGPRVRPECEEEEEEE----DEEEVDEAGLELRDIELVMAQANVSRAK-------AVRALRDNQSDIVNAIMELTM---- --- >Loxodonta_Africana_NACAD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------PFQGSLIFQVDAVEVLLLPTPEEEKAPGSAGDLSGEGEEDSTSASFLQSLSDTS IIEGVDEAFAFRDDTSAASSDSDSASYAGADDERLYSGEPHAQPSTLLQDSRCKVEERQEDWAPSLGQQEPMPVVSKGEV VEIMATQVPCGQEAATAVIPHNWQAEAGPGQEDAARVTPPLLPEEGLTLGEVSMAAPLTLQEEVSATLGHETTATEMPQT LKEEVSLVPCPDSLAMSVTLQNEKEEVGPGLTSGRGSVATATPVPLYEGCILCQESVSMTTPVTLQRKASLTLHRESVSM ATPLPLQKAAALPLGQEPVAMATPQALQEEVGCPLGTAPAA--------------------------------------- -------------------------------------------------------------------------------- ----------------------------SEAALAQPEVGAALGLMSASELVAVAKPSTTEPEAEPVALDQTQQDGVGPAL DLEPVPETVTPMASGKDADLTSEPVPGRGKGQEAARGLSGPEPGTGSGLQHTDDGAGGLESQGDEGLPARTSGSGKALGS SSWMVDLAISPELCQKREPGLPAAMASEAGLDSSPEPSAGAVLGPSGRGCPGEPMSATTPPAPSWVPELGAGAGLQALQ- ---------------------------PHLGMEEQAQAASTHLSHSPCQSQGPYAQELPTEVLDRSQLTEAHDRSPPAED HDTSPPSEAHDRSPPSEAQDTSPPSDDHDTSLPSDDHDTSLPSDDHDMSLPSEARETSPPSKAHGTSPPSEAHDTSPPSH DHDTSPSSEDHDTSPPTEAWDTSPPSEAHDTTSQYPDASLPGFLAGAAPIPCLCQGFREDCRDKGPPGLPGLQQLGTDAP PAAAAVSGNPVPPGAGQQAGLSCPSPPLSPKAAPMGGPHAKALAAHICAPCQVPPCSGLCPPASPLGLSAPEQQEDQDSL EEGKGEERGGPHTPGGVDSYSASSPDSFRAPG------------------------------------------------ -------------------------------------------------------------------------------- ----------------------SGQHSDSHAE-SSAPEMEEQDLAAPRTSR----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------CPPQAPTVGSSEETIAKAKQSRSEKKARKAM SKLGLRQIQGVTRITIQKSK---NILFVISKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPAEPSASASESA PGLRATPECAVGCSRA-QPRVAQQVDETGLELRDIELVMAQANVSRAK-------AVRALRDNHSDIVNAIMELTM---- --- >Xenopus_tropicalis_NACAD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MHSLRETS-----------------AV TLLGIT------------------------KP-----------------------------GPRQ--RG---CESLS--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------HRGSCNDTESNDESLPELEEPDVTEPRTSS----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------SQNQ-LAHCVAPGEESISKAKQSRSEKKARKAM SKLGLRQIHGVTRITIRKSK---NILFVITKPDVFKSPASDIYIVFGEAKIEDLSQQVHKAAAEKFKVPMEHSPLITETT PTL-TIKEESEEE--------EE-VDETGLEVRDIELVMAQANVSRAK-------AVRALRHNNNDIVNAIMELTM---- --- >Danio_rerio_NACAD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MPGENAHRSGPTQSLLDSGDSHSELPGPDLSGQTSSSSASTPTDSASSPSASS PPKLSPLCTPFGPRLVMAKPTTSPRPQPEGASFEFEGHFGTMGRPIGRFGRGACRRGPMKMERIKVLTGSEIESDFQEPE TMDSRVVMGQEALLRNMETQSGMLQEKQRGQEKSSSVNQPTETSKKSTIGLDEKAKLDTGQVCPIVDQGKSVTSEPEQEK ALGQILECQVLESKVRDAESTDSSTLFPENEEEPLSLSQGEVPSLSFSEPPYIVDPQRIGVLPGLDPDRYYTAPSTPIKM AYCSHLKQPWRPGSPSQCPGSPTDESDLCSPPTSPSGSYITAEGGSWTSY-TSSTSHSCSPNLTAEAELQDAPACYVGSL SEIGDDLGDEFTTNYKDACLGKPELPELLENAACKVNILTRDACRPHWVTEHVSTQERSSKKDRDCQQDTEISEGSPRAR TPDATQAINDPYHSLEMDFNACFSEPSVSLDPALTLEDNAASALDAESKTPVTHSPETIDSNSSYLEIGSSFPLFHGYSR DDGPESDA------MIPASMLPFHGSLIFQADSMDITLFPTDDEQGNDVDAYAAGEEEADVDEYDDEYDEDECDGEDVDN DNNAEQQEAANRGERGVEDQNEDDTSASF----LNSLSENSINEGVDESFAYQDDTEESIDSTSYNGDEDDHLYSTEKHA ELSQKFPGPDEPDQSVSHAKPESSGSESEMEISSGSSELPHAELHEDMAESNVRDESKIIQLSETKPLKGEISRELTAQI KTKDEEGKES----RDPSTSEKAQPAPTDNPTSAVSQDKLKQNETTMDSSLEGATAADTSYKTNADGCQQLDQKLGNSME LTYISLQPTETATNDLNKGVPQLTYLDECSPTNIPVCAYPELCDMADNLSSADVLQFERPMNQDNLTENQPANDDVNHGS QNMSCSTYSRLVISPKKENSESSLTERHLYSDSWTPRDPLSLSECCDFEAENLLMCEIARSVHSKGLSVAHNIAAGEDIM GDDEDNNRYCDLPEKMADIDVGVVESNIASWRSIQDLSEAGGGEDDANNLQNPESNALIHCSSEKSLVSSWNDPEKTCTP LIPSELALNMLSNDGKDVKDQTPNADFNIPEDLSTDKLRKE--------------------------------------- -------------------------------------------------------------------------------- ----------------------------STEVDSDQSRDLETCGTLTSIISPECTGLC-GSSKNVISKPSDYLAPIQSLS NSQQITPPDSISENKLAFNLQGGSFGTFTFRKKPTDIKIVATSEATIVQHTSVSHKETSNSNDVVGEKVIQLIPNIKNET ASGEAKSTERKLLDQATTGLPNQEKDKVEQHKKGKRETKARQKKGVQDFKENVLYLEQNKMPDGDSHKSGLSQAECNEA- ---------------------------TPKTARNANLGHDTKPKVIDALKTNTAVSDSMENEKTQCQKKKMKTTSNQTPS FDIFSVKEEIGKTPQNKDVSLAERTEPVQKPEQSIFYSPDSSCIDLKESLHTEPVVATQTADVTKTDEQKELPDSSLSRA SLTESTRDINDNHVGASSSLRVDSSKQDRVSPKCLSTVVQEEDLSTPIQESQPIQDISQTSAGFSRIQPPSNKLSQPVSQ SSLKTTAISSMDLAAWESEESTMTQFPIQDTCNHESERTAMTAIPCRHENFAVCMGHRTEQSQSTTSIGQTDNTCVQRTM KRLDERETLPCIRPRPDSLVKTQQKQAERQSIERDMCPITYRSKDPDDMDLPF--------------------------- -------------------------------------------------------------------------------- -------------------KNNIGSGNETDS-DGSVPELEEPSGTMLRPSN----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------PPLS-----PSPVDESVSRAKQSRSEKKARKAM SKLGLKQIHGVTRITIRKSK---NILFVITRPDVFKSPASDIYIVFGEAKIEDLSQQVHKAAAEKFKVPLDPSPLPSDIT PSL-TIKEESEEE--------EE-LDEGGLEQRDIELVMAQANVSRAK-------AVRALRHNKNDIVNAIMELTM---- --- >Gasterosteus_aculeatus_NACAD_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MPLEDSNLLEVTQGKMMRT-------------------------------------------------- -------------------------------------------------------------------------------- -------------------KKESGESNESES-EGSVPELEEPE---RRPSE----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------PQIFFFFQSTSFSDDGLNRPKQSRSEKKARKAM SKLGLKPVHGVTRITIRKSK---SILFVISRPDVFKSPASDIYIVFGEAKIEDLSQQAHKAAAEKFKVPVTSSPLAPPVP PSL-TIKEESEEE--------EEEVDVGGLEQRDIELVMAQANVSRAK-------AVRALKNNKNDIVNAIMELTM---- --- >Oryzias_latipes_NACAD_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------ESES-EGSIPELEELEP--LRPSE----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------PHVR--LSSIPSADDTLNRPKQSRSEKKARKAM SKLGLKPVHGVTRITIRKSK---SILFVISRPDVFKSPVSDIYIVFGEAKIEDLSQQAHKAAAEKFKVPMMSSPLATPVP PSL-TIKEESEEE--------EEEVDEGGLEQRDIELVMAQANVSRVK-------AVRALKHNNNDIVNAIMELTM---- --- >Homo_sapiens_NACA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MPGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQAS PFPSPSTIASTPLEVPFPQSSSGTALPLG----TAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVA LAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPS-------------------------------------EP KTNLNKVPSE----VVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQN PGSLSLKGPVSPPAALSLSTQSLPV--------------------------VTSSQKTAGPNTPPDFPISLGSHLAPLHQ SSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCS PSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISN IEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDL--------------------------------------- -------------------------------------------------------------------------------- ----------------------------KNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAP KNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAA FPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEG---------------------------------- ---------------------------TLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEI--PKSVPSPSLPPAGT PPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNL SSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPA PKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKG APTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATL PSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPP PKGAPTTPAATPPSPKGGLATPPPKGAPTTPA-ATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAA TPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPAT SPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPA MTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKG DPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLA PKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPS PEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKG PQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLP KPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMP TPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSK---NILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENT QTP-TVQEESE----------EEEVDETGVEVKDIELVMSQANVSRAK-------AVRALKNNSNDIVNAIMELTM---- --- >Mus-Muculus_NACA MPGEATETVPATEQELPQPQAETAVLPMSSALKV-AAVGQPGPTPPSSLGPQQSPIVT-AHQPSPLPSSVSSTPFEVPFA QPITAETALPSGTAPPTPTFLPHLIGPPISPAALALASPMIGLAQKGARSSSAPLSLVALAPHSVQKSSVCPPHPLTSPP SAAGAELGALT---ASIPPLEPKTSTSQVPSQGTLNLKG-TAPCPPDVVRAFPSHLENPLASVQPGLMSCPQTLSNTSPV KGVPISSALTQSRLSLNLKGPVSPPARNTAAPSIPLAPSTSLGCHLPLLHHSSVDSPIQPPGQSGLAVSNPTSVGHSGIA ASCPPERCVVPALPSR-LLAVDSGAAPSDDKGSSAVTNELCSPPGSSNVAGTSLSPKASLVPKGSNVALQPLVTQVPASQ KTGLKEIPVSCIGATHHALDNPSAISVAPATHVPPPTSSGLVSSKDPASPVTSLVVPAAHKQFPAPPASATLGVPVSPLP ATEGLKNLPISALVNVGAPVSPAQAGLPTRKDTTLQPLAPIALKESPSSQSASSLEVLSEDTVTKKTTGGPAPVVRPAIA GVATTTSLR---ADSPPAVIRADSCVSPNTVSQPLKRSVTDPAMAPRTAKNTAPSTTSPLVPLASEGCPVASSMALSPQN ASVSETALALSPEIPKSVPFPDPPLAEISFSNARKVDAVSHMESSGSSRQGHPDASVTAKGTVVCLADSSLDTSVSASKG SALSGASSPLYPLEVSFLPEAG----LAVQGPKGSLNKLSPTPPSSKGAPVPSTGAPPSPKGAPIVPTESSISSKQVPAE ILPSPQKTPEVTASRLISAVQSPKVDPIMSDVTPTSPKKTSATAVPKDTSATLSLKSVP--------------------- -------------AVTSLSPPKAPVAPSNEATIVP-TEIPTSLKNALAAATPKETLATS-------IPKVTSPSPQKTPK SVSLKGAP------AMTSKKATEIAASKDVSPSQFPKEVPLLPHVPPTSPPKSPVSDTLSGALTSPPPKGPPATLAETPT YPKKSPKPAASKKTPATPSPEGVTAVPLE----IPPCSKKAPKTAAPKESSATSSSKRAPKTAVSKEIPSKGVTAVPLEI SLPLKETSKSATPGEKSASSPKRSPKTAGPKETPPGGVTAVPPEISLPPKETPQNATPNESLAASSQKRSPKTSVPKETP PGGVTAMPLE----IPSAPQKAPKTAVPKQIPT---PEDAVTILAGSPLSPKKASKTAAPKEAPATPSVGVIAVSGEISP SPKKTSKTAAPKENSATLPPKRSPKTAAPKETP-----------------ATSSEGVTAVPSEISPSPPTPASKGVPVTL TPKGAPNALAESPASPKKVPKTAAPEETSTTPSPQKIPKVAGPKEASATPPSKKTPKTAVPKETSAPSEGVTAVP--LEI PPSPRKAPKTAAPKETPAPSPEGATTAPVQIPPSPRKGSKKAGSKETPTTPSPEGVTAAPLEIPISSKKTSKMASPKETL VTPSSKKLSQTVGPKETSLEGATAVPLEIPPSHKKAPKTVD--------------------------------------- -------------------------------------------------------------------------------- ----------------------------PKQVPLTPSPKDAPTTLAESPSSPKKAPKTAAPPSERVTTVPPEKPATPQKA SATTASKVPVPAETQEVAVSSRETPVTPAVPPVKNPSSHKKTSKTIELKEAPATLPPSPTKSPKIPSSKKAPRTSAPKEF PASPSIKPVTTSLAQTAPPSLQKAPSTTIPKENLAAPAVLPVSSKSPAAPAAASASLS--------------------P- ---------------------------ATAAPQTAPKEATTIPSCKKAAATETPIETSTAPSLEGAPKETSETSVSK--- --VLMSSPPKKASSSKRASTLPATTLPSLKEASVLSPTATSSGKDSHISPVSDACSTGTTTPQASEKLPSKKGPTAFTEM LAAPAPESALAITAPIQKSPGANSNSASSPKCPDPSSKKDTKGLPSAVALAPQTVPVEKDTSKAIETLLVSPAKGSDCLH SPKGPVGSQVATPLA---AFTSDKVPPEAVSASVAPKPAPAASLTLAPSPVAPLPPKQPLLESAPGSVLESPSKLPVPAE EDELPPLIPPEAVSGGEPFQPILVNMPAPKPAGTPAPAPSAKQPVLKNNKG----------------------------- -------------------------------------------------------------------------------- ------------------------SGTESDSD-ESVPELEEQDSTQTAT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------QQAQLAAAAEIDEEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSK---NILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENT QTP-TVQEESE----------EEEVDETGVEVKDIELVMSQANVSRAK-------AVRALKNNSNDIVNAIMELTM---- --- >Rattus_norvegicus_NACA MPGEATETVPATEQELPQPQAETAVLPMSSALNVTAAPGQPGSPSPSSLGPQQSPLVTAAHQSSPLPSSLPSTPFEVPFA QP---ETAVPSGAAPPAPTFLPHLIGPPISPAALALASPVIGPAQKGARSSSAPLSLVALAPHSIQKSSVCPPHPLTLPP SAAGAESGALTSLTASIPLLESKASTSQVPSQGTPNLKGTTTPCPPDVVSAFPSHLENPLASVQPGLTSCPQTLSITSPV KGVPISSALTQSLLSLNLRGPVSSPPQSTVTPSIPPAASASLGSPLPLLHHSSLDSPVQPPGQSGLTVNTTISVDHPFVA ASYPPERSAVSPLPSRHELAADSGAAPSIDKGSSAVTKETCSSSGSANEAGTSLSPAAPLTPKSSNAALQPSVTQVPPPQ KPGLKETPASCIRAMHPALDNPSTMSVAPATHVSPPASSGLIKSEDPASPVSSLSVPAAHKPFPAPSMSTTLGIPVSPLP ATEGLQNLPIS--VNAGAPVSPAQAGLPIRKDTTVQTLAPVALKESPSSQSASSLEVLSED--TKKTTGGPAPVVRPAIA TGAPTTLDYPPAGYVNPNPVSQPLKSSAPAMAPFLSESCDSKGLVPRTAKDTFPSVNSPLVPLPSEGCPVAPSMALSHQN ASVSVT-------TAKSVPFPAPPSAGVSFSSAKKVDVVSQMESSDSSQEGHPNASVSSQTKRPASKKGSFPSDVSPGNV S------SPHCSLETSFLPEAG----LSFQGPKGAS----------------------------IVPTETSVSSKKTPAE ILPSPQKTPTATASRLTSAVQSPKLDPTVSDVIP-------ATVVPRDTSASLSLKSVP--------------------- -------------AVTSLSSQKAPAAPSPNEALVAPTEIPTSLKNALATTAPKETLATSTLKVASTAPVVTSPSPQKTPK SVSPKGAP------AVTSKKAKEIAASKEVSTSQFPKEAPLLPHAAPTSPPKSPATDPLNGALTSPSPKVAPATLVESPT SPKKAPKTAAPKETPVTPSLEGVTAVPLE----INPCPKKAPKTSTPKESSVTLSSKRTPKSAVSKEIPSNEVTAVPLEI SLPLKETSKSAIPVEKSTSSSKSSPKTVAPKETLPEEVTAVPLEVSLPPKEMPQN------------------ASPRETP PEGVTAVPLE----IPPTPKKAPKTSVPKQIPVTPSPKDAFTTLAESPPSPKKAPTTAAPKEVPAAPSVGITAVS-EISP SPKKTSKTAVPKEDSATSYPKRSPKTATPKENSTSSPKRSPKIEAPKETLATSPEGVTAMPLEIPPSPAAPASKRVPVTP SPKGASNTLAESSASPKKAPKTAAPKETS-TPSPQKIPKMSGPKETPATPPSKKSPKTVAPKETSAPSEGVTALP--LKV PPSPRKAPKTAVPKETPAPSPEGVTTALVQIPPSPRKVKR-TSSKETPTNPSPEGVTAAPLEIPLTSKKNPKMASPKEML VTPPSKKVSQTGDPKETPPEGVTAVPLEILPSPKKTPKTVV--------------------------------------- -------------------------------------------------------------------------------- ----------------------------PKQVPVTPSPKDAPTTLAESPPSPKKAPTTAAPPSERVTTAPPEKPATPQKA SATVASKVLVPAETLEVAVSPKET----------HPSSHKKTPKTVDLKEGPAALPPSPTKSPKISSSKKAQNTSAPIEF PASSSIKAVTTSLAQTVP-CVQKAPSTIAPQENSAAPVAIPVSNKSPAAPTTANASVALAAASLSPTPQVKISPSKKTP- ---------------------------ATSALQTVPKEATTIPSGKKAPAIETSNETSTTLSLKGAPKETSETSTSKGVL TSTVNSSSPKKVPSSKRASTLPATTLPSIKEASVLSPVPTSSTKDSHTYPVSTACSTATTTPQASEKLPAKKEPAALTEV PAAPAPESALAITVPIQKVPRTKRNSASPPKCPDPSAKKDTKGLLSAVALAPQTVPVEKNSSKPIEVLPLCPAKGSDSVH SPKGPMESQEATPQA---AFTSDKVLPKAVSKSVAPKPTLAASLTLAPSPVPPLPPKQPFLQSAPESVLESPSKLPVPAD EDELPPLIPPEAVSGGVPFQPILVNMPTPKPAGIPAPAPSAKQPVLKNNKG----------------------------- -------------------------------------------------------------------------------- ------------------------SGTESDSD-ESVPELEEQDSTQTAT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------QQAQLAAAAEIDEEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSK---NILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENT QTP-TVQEESE----------EEEVDETGVEVKDIELVMSQANVSRAK-------AVRALKNNSNDIVNAIMELTM---- --- >Bos_taurus_NACA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MPGEATDT-----VPAT EQELP---QPQAETG----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SGTESDSD-ESVPELEEQDSTQATT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------QQAQLAAAAEIDEEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSK---NILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENT QTP-TVQEESE----------EEEVDETGVEVKDIELVMSQANVSRAK-------AVRALKNNSNDIVNAIMELTM---- --- >Monodelphis_domestica_NACA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M DPSPRGPPSPAQMDST---TKKDPATPLAPFPLSPKETTTIPAATLFP------------LELTLSS-----AAPPASLP LTPSSPESSHLPSAMAVSPLGASVTPQTTEVLPDKTSSASI--------------------------------------- -------------------------------------------------------------------------------- ----------------------------PTSL-----------TLASAVPPSVPVPSVFTAPSPKRTPDSPEIATSSLEG TITPN-------------------------------SISTKKDSISFLASDLALTTPSPKGSPLTQVVLPPAPKGAPTTS PAVP--------LAPTAPPSPKKAPAT----------------------------------------------------- ---------------------------PPAVPPSVPKEVPIVPPSPKEALTVP---SATTLPLKGTPVSP---------- -PAVPSPSPKGAPTPAVPGSPQTPKGSSAKKGSDISPAVASTLSPKVTSDSPYAATSPPAPKGPPTKKDSAISPAAPKDT PTAPASIPLTPTVT--SDSSSVATSPLEATVSPAPKGLPTKKGSATSPAAPKDTPTPPASSPLEATVSPPAPKGSPTKKG SATSPAAPKGTPTPP---ASPLEATVPPPAPKGSPTKKGSATSSAAPKAPPPLLPKQQPLLPSSPGLVPEAPSKPQAPAD EDELPPLIPPEPPSGGVPFQPVLVDIPTPKSAGVPAPVPPVKQPVLKNNEG----------------------------- -------------------------------------------------------------------------------- ------------------------SGTESDSD-ESVPELEEQDSTQATT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------QQAQLAAAAEIDEEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSK---NILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENT QTP-TVQEESE----------EEEVDETGVEVKDIELVMSQANVSRAK-------AVRALKNNSNDIVNAIMELTM---- --- >Xenopus_tropicalis_NACA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MPPLIPPEAPPQEHAFHPVMVDFGSPK----VVQTPPVKEAVLKNDKG----------------------------- -------------------------------------------------------------------------------- ------------------------SGTESDSD-DSPPELE-QDSTQTTT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------QQAQLAAAAEIDEEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSK---NILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENT QTP-TVQEESE----------EEEVDETGVEVKDIELVMSQANVSRAK-------AVRALKNNSNDIVNAIMELTM---- --- >Takifugu_rubripes_NACA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------KATEKVKSAPVEAAKP-VEK------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------LGSGTESDSD-DSVPELEEQDSAQTQT------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------QQAQLAAAAEIDEEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSK---NILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSSIQENT QTP-TVQEESE----------EEEVDETGVEVKDIELVMSQANVSRAK-------AIRALKNNNNDIVNAIMELTM---- --- >Tetraodon_nigroviridis_NACA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MPGEATETVPVTEQEMQQPQVETVN---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------------RAVSHG CPLESADSQGTGSLSEVSIQATSDQPSDVP-------------------------------------------------- -------------------------------------------------------------------------------- -----DAQGIPEKSEDNQSPVVQQEAAADSVECATDPTVPSSCVSQVIKENVTQVCTNEEVAPQEMKVPDGMISGEKPEV MADSSPYSSKACGLEDMPVSTEDGKPASGHEPAIEEPKSDGDKTFPGDLKVDEATSNENLEKMEAVSIPAQVNQSKGISK CEDTRLSTQPLSG------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SGTESDSD-DSVPELEEQDSTQTQT------------------------------- -------------------------------------------------------------------------------- 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