>Homo_sapiens_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTEPGASPEDP---WVKASPVGAHAGEGRAGRARARRGAGRRG ASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPG--------------------------------------- ----------------------------------------LFVESTRKGSVVSRANSIG--STSASSVPNTDDEDSDYHQ EA--------------------YKESYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKRGYDDLQTIVPTCQQQ-DFSI GSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPH----------------EGE DQVSDQVKFNVFQGIMDSLFQSFNASISVASF------QELSACVFSWIEEHCKPQTLREIVIGVLHQL-KNQLY----- -------------------------- >Mus-Muculus_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTEPGASPEDP---WVKASFADAHAGEGRAGRARARRGSGRRG APQLSPESPLLSGARGCREDSSHPACAKVEYAYSDNSLDPG--------------------------------------- ----------------------------------------LFVESTHKGSVVSRANSIG--STSASSVPNTDDEDSDYQQ ES--------------------YKESYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKRGYDDLQTIVPTCQQQ-DFSI GSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPH----------------EGE DQVSDQVKFNVFQGIMDSLFQSFNASISVASF------QELSACVFSWIEEHCEPQTLREIVIGVLHQL-KNQLY----- -------------------------- >Pan_troglodytes_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTEPGASPEDP---WVKASPVGAHAGEGRAGRARARRGAGRRG ASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPG--------------------------------------- ----------------------------------------LFVESTRKGSVVSRANSIG--STSASSVPNTDDEDSDYHQ EA--------------------YKESYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKRGYDDLQTIVPTCQQQ-DFSI GSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPH----------------EGE DQVSDQVKFNVFQGIMDSLFQSFNASISVASF------QELSACVFSWIEEHCKPQTLREIVIGVLHQL-KNQLY----- -------------------------- >Gorilla_gorilla_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTEPGASPEDP---WVKASPVGAHAGEGRAGRARARRGAGRRG ASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPG--------------------------------------- ----------------------------------------LFVESTRKGSVVSRANSIG--STSASSVPNTDDEDSDYHQ EA--------------------YKESYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKRGYDDLQTIVPTCQQQ-DFSI GSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPH----------------EGE DQVSDQVKFNVFQGIMDSLFQSFNASISVASF------QELSACVFSWIEEHCKPQTLREIVIGVLHQL-KNQLY----- -------------------------- >Macaca_mulatta_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTEPGASPEDP---WVKASPVGAHASEGRAGRARARRGAGRRG ASLLSPKSPMLSGPRGCREDSSHPACAKVEYAYSDNSLDPG--------------------------------------- ----------------------------------------LFVESTRKGNVVSRANSIG--STSASSVPNTDDEDSDYHQ EA--------------------YKESYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKRGYDDLQTIVPTCQQQ-DFSI GSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPH----------------EGE DQVSDQVKFNVFQGIMDSLFQSFNASISVASF------QELSACVFSWIEEHCKPQTLREIVIGVLHQL-KNQLY----- -------------------------- >Rattus_norvegicus_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTEPGASPEDP---WVKASSADAHAGEGRAGRARARRGSGRRG APQLSPESPLLSRPRGCREDSSHPACAKVEYAYSDNSLDPG--------------------------------------- ----------------------------------------LFVESTHKGSVVSRANSIG--STSASSVPNTDDEDSDYQQ ES--------------------YKESYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKRGYDDLQTIVPTCQQQ-DFSI GSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPH----------------EGE DQVSDQVKFNVFQGIMDSLFQSFNASISVASF------QELSACVFSWIEEHCEPQTLREIVIGVLHQL-KNQLY----- -------------------------- >Bos_taurus_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTEPGASPEDP---WVK-------------------------- ----------------------------VEYAYSDNSLDPG--------------------------------------- ----------------------------------------LFVESTRKGSVVSRANSIG--STSASSVPNTDDEDSDYHQ ES--------------------YKESYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKRGYDDLQTIVPTCQQQ-DFSL GSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVMALKIMKVNYEQIVKAHQDNPH----------------EGE DQVSDQVKFNVFQGIMDSLFQSFNASISVASF------QELSACVFSWIEEHCKPQTLREIVIGVLHQL-KNQLY----- -------------------------- >Loxodonta_Africana_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTEPVASPEDP---WVKASPVGANAGEGRAGRARARRGFGRRG DSLLFPKSPPCSGTRGYREDSSRPALAKVEYAYSDNSLDPG--------------------------------------- ----------------------------------------LFVEGTRKGSVVSRANSIG--STSASSVPNTDDEDSDYHQ ES--------------------YKESYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKRGYDDLQTIVPTCQQQ-DFSI GSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPH----------------EGE DQVSDQVKFNVFQGIMDSLFQSFNASISVASF------QELSACVFSWIEEHCKPQTLREIVIGVLHQL-KNQLY----- -------------------------- >Monodelphis_domestica_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTERGASPEDP---WVK-------------------------- ----------------------------VEYTYSDNSLDPG--------------------------------------- ----------------------------------------LFVESNRKGSVVSRANSIG--STSASSVPNTDDEDSDYQQ EP--------------------YKESYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKRGYDDLQAIVPTCQQQ-DFSI GSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVMALKIMKVNYEQIVKAHQDNPH----------------EGE DQVSDQVKFNVFQGIMDSLFQSFNASISVASF------QELSACVFSWIEEHCKPQTLQEIVTGVLHQL-KNQLY----- -------------------------- >Ciona_intestinalis_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MSSSSYNDSSFDHLS-------------------------------------- ----------------------------------------DSPSHIDVEMATNT-LQISNPSSAASSVPNTDEEDEDTSD KH---------------------HQSYKERRRE----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEKKRREAIRKGYDELQLIVPNLVQQ-ADVI GSQKLSKAVILQRSLNYVEFLQQQKKKQIEELNQLRKEKMALAIMKASYEQIVKQQMKFSD----------------GAQ GKVSEEVKFNIFQQVMEKLFVTFNSTITTNTF------QDVSHGIINWIEEHCKPPMLRNIVNEVLGMASSTTYYGSQRF -------------------------- >Ciona_savignyi_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MAGPSFNDSNFDQLN-------------------------------------- ----------------------------------------DSPCHPDIEMAATTSLHISNPSSAASSVPNTDEEDDEAVD K----------------------LQTYKERRRE----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEKKRREAIRKGYDELQLIIPNLQQE-DTIG GSQKLSKAVILQRSLSYVEFLQQQKKKQIEELNQLRKEKMALAIMKASYEQIVKQQLKTGT----------------GVQ GKVSEDLKFNIFQQLMEKMFVSFNEAVSTDTF------QDASHCIINWIEEHCKPQRLRTVVNEVLMMASNSMYYCS--- -------------------------- >Homo_sapiens_MLXIP ---MAADVFMCSPRRPRSRGRQVLLKPQVSEDDDD-SDTDEPSPPPASGAATPARAHASAAPPPPRAGPGR--------- ------------EEPPRRQQIIHSGHFMVSSPHREHP--------------------------PKKGYDFDTVNKQTCQT YSFGKTS---------SCHLSIDASLTKLFECMTLAYSG-KLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKR- -KNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQ------------HKDEDLSSLV QDDD----MLYWHKHGDGWKTPVPM---EEDP----LLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLG-NADMIQ PGLIPLQPNLDFMDTFE----PFQDLFSSSRSI----------------------------------------------- -----------------------------------------------------------------------FGSMLPASA SAPVPDPNNPPAQESILPTTALPTVSLPDSLIAPPTAPSLAHMDEQGCEHTSRTEDPFIQPTDFGPSEPPLSVPQPFLPV FTMPLLSPSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQ-KFAGVNKAPSVITHT----------------------- ---ASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLALSPVTRP-----PQPRLTFVHPKPVSLTGGRPKQ------ --------PHKIVPAPKP-EPVSLVLKNARIAPAAFSGQPQAVIMTSGPLKREGMLASTVSQSNVVIAPAAIARAPGVPE FHSSILVT-DLGHGTSSPPAPVSRLF-PSTAQDPLGKGEQVPLHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQ NNCSGKS--DPKNVAALK-----------------------NRQMKHISAEQKRRFNIKMCFDMLNSLISNNSKL----- ----TSHAITLQKTVEYITKLQQERGQMQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFD---HMKDMFDEYVK TRTLQNWKFWIFSIIIKPLFESFKGMVSTSSL------EELHRTALSWLDQHCSLPILRPMVLSTLRQLSTSTSILTDP- AQLPEQASKAVTR--IGKRLGES--- >Mus-Muculus_MLXIP ---MAADVFMCSPRRPRSRGRSVLLKPQVPEDDDD-SDTDEPSPPPPSGVATSARAHASAAPLPPRAGPGR--------- ------------EEPPRRQQIIHSGHFMVSSPHREHP--------------------------PKKGYDFDTVNKQTCQT YSFGKTS---------SCHLSIDASLTKLFECMTLAYSG-KLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKR- -KNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQ------------HKDEDLSSLA QDDD----MLYWHKHGDGWKTPVPM---EEDS----LLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLG-NADMIQ PGLIPLQPNLDFMDTFE----PFQDLFSSSRSI----------------------------------------------- -----------------------------------------------------------------------FGSMLPPPS SLPAADPSSPPSQGNILPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQPFLPV FTMTLLSPGPAPAPVPTALPLVPSPAPTLNPPTPPAFLQPQ-KFAGVSKSTPVITHT----------------------- ---ASATLTHDASATTFSQNQGLVITAHHPTPSSSPCALALSPVPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQ------ --------PPKIVPAPKP-EPVSLVLKNACIAPAAFSGQPQKVIMTSAPLKREGILASTVSPSNVVIASAAITRASGVTE FLS---------HSTSSQPSPVSRLFSPSTVQDSLVKGEQVSLHGGSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSPQ NNCSGKST-DPKNVAALK-----------------------NRQ-KHISAEQKRRFNIRMGFNTLNSLISNNSKQ----- ----TSHAITLQKTMEYITKLQQERMQMQEEARRLREEIEELNTTIISCQQLLPATGVPVNCRQLD---HMRDMFDEYVK SRTLQNWKFWIFSMIIKPLFESFKGMVSTSSL------EEFHRTALSWLDQHCSLPVLRPMVLSTLRQLSTTTSILTDP- SQLPEQASEAVTR--MGKRSGES--- >Pan_troglodytes_MLXIP ---MAADVFMCSPRRPRSRGRQVLLKPQVSEDDDD-SDTDEPSPPPASGAATPARAHASAAPPPPRAGPGR--------- ------------EEPPRRQQIIHSGHFMVSSPHREHP--------------------------PKKGYDFDTVNKQTCQT YSFGKTS---------SCHLSIDASLTKLFECMTLAYSG-KLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKR- -KNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQ------------HKDEDLSSLV QDDD----MLYWHKHGDGWKTPVPM---EEDP----LLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLG-NADMIQ PGLIPLQPNLDFMDTFE----PFQDLFSSSRSI----------------------------------------------- -----------------------------------------------------------------------FGSMLPASA SAPVPDPNNPPAQESILPTTALPTVSLPDSLIAPPTAPSLAHMDGQGCEHTSRTEDPFIQPTDFGPSEPPLSVPQPFLPV FTMPLLSPSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQ-KVAGVNKAPSVITHT----------------------- ---ASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLALSPVTQP-----PQPRLTFVHPKPVSLTGGRPKQ------ --------PHKIVPAPKP-EPVSLVLKNARIAPAAFSGQPQAVIMTSGPLKREGMLASTVSQSNVVIAPAAIARAPGVPE FHSSILVT-DLGHGTSSPPAPVSRLF-PSTAQDPLGKGEQVPLHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQ NNCSGKS--DPKNVAALK-----------------------NRQMKHISAEQKRRFNIKMCFDMLNSLISNNSKL----- ----TSHAITLQKTVEYITKLQQERGQMQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFD---HMKDMFDEYVK TRTLQNWKFWIFSIIIKPLFESFKGMVSTSSL------EELHRTALSWLDQHCSLPILRPMVLSTLRQLSTSTSILTDP- AQLPEQASKAVTR--IGKRLGES--- >Gorilla_gorilla_MLXIP ---MAADVFMCSPRRPRSRGRQVLLKPQVSEDDDD-SDTDEPSPPPASGAATPARAHASAAPPPPRAGPGR--------- ------------EEPPRRQQIIHSGHFMVSSPHREHP--------------------------PKKGYDFDTVNKQTCQT YSFGKTS---------SCHLSIDASLTKLFECMTLAYSG-KLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKR- -KNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQ------------HKDEDLSSLV QDDD----MLYWHKHGDGWKTPVPM---EEDP----LLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLG-NADMIQ PGLIPLQPNLDFMDTFE----PFQDLFSSSRSI----------------------------------------------- -----------------------------------------------------------------------FGSMLPASA SAPVPDPNNPPAQESILPTTALPTVSLPDSLIAPPTAPSLAHMDGQGCEHTSRTEDPFIQPTDFGPSEPPLSVPQPFLPV FTMPLLSPSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQ-KFAGVNKAPSVITHT----------------------- ---ASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLALSPVTRP-----PQPRLTFVHPKPVSVTGGRPKQ------ --------PHKIVPAPKP-EPVSLVLKNARIAPAAFSGQPQAVIMTSGPLKREGMLASTVSQSNVVIAPAAIARAPGVPE FHSSILVT-DLGHGTSSPPAPVSRLF-PGTAQDPLGKGEQVPLHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQ NNCSGKS--DPKNVAALK-----------------------NRQMKHISAEQKRRFNIKMCFDMLNSLISNNSKL----- ----TSHAITLQKTVEYITKLQQERGQMQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFD---HMKDMFDEYVK SRTLQNWKFWIFSIIIKPLFESFKGMVSTSSL------EELHRTALSWLDQHCSLPILRPMVLSTLRQLSTSTSILTDP- AQLPEQASKAVTR--IGKRLGES--- >Macaca_mulatta_MLXIP ---MAADVFMCSPRRPRSRGRQVLLKPQVPEDDDD-SDTDEPSPPPASGAATPARAHASAAPPPPRAGPGR--------- ------------EEPPRRQQIIHSGHFMVSSPHREHP--------------------------PKKGYDFDTVNKQTCQT YSFGKTS---------SCHLSIDASLTKLFECMTLAYSG-KLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKR- -KNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQ------------HKDEDLSSLV QDDD----MLYWHKHGDGWKTPVPM---EEDP----LLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLG-NADMIQ PGLIPLQPNLDFMDTFE----PFQDLFSSSRSI----------------------------------------------- -----------------------------------------------------------------------FGSMLPASA SAPVPDPNNPPAQESVLQTTALPTVSLPDSLIAPPTAPPLAHVDGQSCEHTSRAEDPFIQPTDFGPSEPPLSVPQPFLPV FTMPLLSPSPAPPPVSPVLPLVPPPATALNPPAPPTFHQPQ-KFAGVSKVPSVITHT----------------------- ---ASATLTHDASATTFSQSQGLVITTHHPAPSAAPCGLALSPVPRP-----PQPRLTFVHPKPVSLTGGRPKQ------ --------PHKIVPAPKP-EPVSLVLKNTCIAPAAFSGQPQAVIMTSGPLKREGMLASTVSQSNVVIAPAAIARAPGVPE FHSSILVT-DLGHGTNSPPAPISRLF-PSTAQDPLGKGEQVQLHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQ NNCSGKS--DPKNVAALK-----------------------NRQMKHISAEQKRRFNIKMCFDMLNSLISNNSKL----- ----TSHAITLQKTVEYITKLQQERGQMQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFD---HMRDMFDEYVK SRTLQNWKFWIFSIIIKPLFESFKGMVSTSSL------EELHRTALSWLDQHCSLPILRPMVLNTLRQLSTSTSILTDP- AQLPEQASKAVTR--IGKRLGES--- >Homo_sapiens_MLXIPL ---------MAGALAGLAAGLQVPRVAPSPDSDSD-TDSEDPSL---------------------RRSAGG--------- ---------------LLRSQVIHSGHFMVSSPHSDSL--------------------------PRR----------RDQE GSVGPSD---------FGPRSIDPTLTRLFECLSLAYSG-KLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRR- -KSPVCGFVTPLQG-PEADAHRKPEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKP-----------SREDDLLAPK QAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGRQLLDLNCFLSDISDTLF-TMTQSGPSPLQLPPEDAYVG-NADMIQ PDLTPLQP---SLDDFM----DISDFFTNSRLP----------------------------------------------- -----------------------------------------------------------------------QPPMPSNFP EPPSFSPVVDSLFSSGTLGPEVPP-----ASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPP PLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLP----------------------- ---APAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPR--------------GKPPAPSPRGQKASP------ --------PTLAPATASPPTTAGS--NNPCLTQLLTAAKPEQALEP--PLVSSTLLRSPGSPQ------------ETVPE FP---------CTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQ PILSRGR----PDSNKTE-----------------------NRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQP---- -SLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFD---QMRDMFDDYVR TRTLHNWKFWVFSILIRPLFESFNGMVSTASV------HTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDP- GRIPEQATRAVTEGTLGKPL------ >Mus-Muculus_MLXIPL ---------MARALADLSVNLQVPRVVPSPDSDSD-TDLEDPSP---------------------RRSAGG--------- ---------------LHRSQVIHSGHFMVSSPHSDSL--------------------------TRR----------RDQE GPVGLAD---------FGPRSIDPTLTHLFECLSLAYSG-KLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRR- -KSPVCGFVTPLQG-SEADEHRKPEAVILEGNYWKRRIEVVMREYHKWRIYYKKRLRKS-----------SREGDFLAPK QVEGGWPPPERWCEQLFSSVVPVLLGGSEEEPGGRQLLDLDCFLSDISDTLF-TMTQPSPSSLQLPPEDAYVG-NADMIQ PDLTPLQP---SLDDFM----EISDFFTNYRPP----------------------------------------------- -----------------------------------------------------------------------QTPTSSNYI ESPSFGPMADSLFSSGILAPEMPSPASSSSSSGMTPHSGNTRLQARNSCSGPLDPNPFLSSEFLLPEDPKTKIPPAPGPT PLLPFPTPVKVHGLEPCTPSPFPTMAPPPSLLPEESLLSARFPFTSAPPAPGVSTLP----------------------- ---APTTFVPTPQ--PGPGPVPFSVDHLPHGYLEPVFGPHFTVPQGM---------QPRCKPSSPSPGGQKASP------ --------PTLASATASPTATATARDNNPCLTQLLRAAKPEQALEP--PTMPGTLLRPPESPQ------------DTVSE IPRA-------RAFFPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSERRLSGDLNSIQPSGALSVHLSPPQ TVLSRGR----VDNNKME-----------------------NRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQP---- -SLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFD---QMRDMFDDYVR TRTLHNWKFWVFSILIRPLFESFNGMVSTASL------HSLRQTSLAWLEQYCSLPALRPTVLNSLRQLSTSTSILTDP- SLVPEQATRAVTEGTLGRPL------ >Pan_troglodytes_MLXIPL ---------MAGALAGLAAGLQVPRVAPSPDSDSD-TDSEDPSL---------------------RRSAGG--------- ---------------LLRSQVIHSGHFMVSSPHSDSL--------------------------PRR----------RDQE GSVGPSD---------FGPRSIDPTLTRLFECLSLAYSG-KLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVERR- -KSPVCGFVTPLQG-PEADAHRKPEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKP-----------SREEDLLAPK QAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGRQLLDLNCFLSDISDTLF-TMTQSGPSPLQLPPEDAYVG-NADMIQ PDLTPLQP---SLDDFM----DISDFFTNSRPP----------------------------------------------- -----------------------------------------------------------------------QPPMPSNFP EPPSFSPMVDSLFSSGTLGPEVPP-----ASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPTPPVPP PLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLP----------------------- ---APAAFPPTPQSVPSPAPTPFPIELLPLGYSEPTFGPCFSMPR--------------GKPPAPSPRGQKASP------ --------PTLAPATASPPTTAGS--NNPCLTQLLTAAKPEQALEP--PLVSSTLLQSPGSPQ------------ETVPE FP---------CTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQ PILSRGR----PDSNKTE-----------------------NRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQP---- -SLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFD---QMRDMFDDYVR TRTLHNWKFWVFSILIRPLFESFNGMVSTASV------HTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDP- GRIPEQATRAVTEGTLGKPL------ >Gorilla_gorilla_MLXIPL ---------MAGALAGLAAGLQVPRVAPSPDSDSD-TDSEDPSL---------------------RRSAGG--------- ---------------LLRSQVIHSGHFMVSSPHSDSL--------------------------PRR----------RDQE GSMGPSD---------FGPRSIDPTLTRLFECLSLAYSG-KLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVERR- -KSPVCGFVTPLQG-PEADAHRKPEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKP-----------SREEDLLAPK QAEGRWPPPEQWCKELFSSVVPVLLGDPEEEPGGRQLLDLNCFLSDISDTLF-TMTQSGPSPLQLPPEDAYVG-NADMIQ PDLTPLQP---SLDDFM----DISDFFTNSRPP----------------------------------------------- -----------------------------------------------------------------------QPPMPSNFP EPPSFSPMVDSLFSSGTLGPEVPP-----ASSAMTHLSGHSRLQVS---------------------------------- -------------------SPHPVQPCVAHLRAGPALFMSRNQFP----------------------------------- --------------------------------------ICNSFFF--------------FKPPAPSPRGQKASP------ --------PTLAPATASPPTTAGS--NNPCLTQLLTAAKPEQALEP--PLVSSTLLRSPGSPQ------------ETVPE FP---------CTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERQLSGDLSSMPGPGTLSVRVSPPQ PILSRGR----PDSNKTE-----------------------NRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQP---- -SLKVSKATTLQKTAEYIIMLQQERAGLQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFD---QMRDMFDDYVR TRTLHNWKFWVFSILIRPLFESFNGMVSTASV------HTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDP- GRIPEQATRAVTEGTLGKPL------ >Macaca_mulatta_MLXIPL ---------MAGALAGLAAGLQVPRVGPSPDSDSD-TDSEDPSL---------------------RRSAGG--------- ---------------LLRSQVIHSGHFMVSSPHSDSL--------------------------PRR----------RDQE GSVGPSD---------FGPRSIDPTLTRLFECLSLAYSG-KLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQCEWAP- -AASPAGRDRPLQ--PSCQTVLHAEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKS-----------SREEDLLAPK QAEGGWPPPEQWCKQLFSSVVPVLLGDPEEEPGGRQLLDLNCFLSDISDTLF-TMTQSGPSPLQLPPEDAYVG-NADMIQ PDLTPLQP---SLDDFM----DIS-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Ciona_intestinalis_MLXIPL -------MECSAEKMFPTTSLITSSVTQSTNSEQDIYKSPKKGDVIHSG----------HFMVSSVADDGD--------- ----------------EHEEINHDRDSPVHHEQAIMI--------------------------RGHGYDFSNVNKETKNI YQFGPSH---------SNHITIDSSLSRLFKCMSLAYRGGKVVSPKWKNFKGLKLTVKDKIRLNNAIWRTWHIQYVMHR- KKPSLIQFATPLEADLECDLHNRPEAVVMEGKYWKRRIETVVAEYKKWRAFFMEKLRLS-----------EYPG------ ---------LTWVSDIQNSPS-------SDHNLESHRRFEEQNATDFTDTLFSSLSNQ-PFQFPNPREIAMHATNSDMMQ PGLLQLQP-MMDDMDFD----PLQDFFAPPKKS----------------------------------------------- -----------------------------------------------------------------------NTGFGTGLH HND--RIAEEGFISHGINQM----IDASHIEPIQQSNEIAMQYAPHPQLKVTTHSDPIFSAFNITQYSGLNVDVAHATNI NQHQTIDPTFKQYPSQNMGVPKQ-----NNMGNNQSQQTMRYTSQEQPGFSKISQNN----------------------- ---LPNNRIIYTQPQTSLQMEVLQTPAHHIGSTLVENNPNQYATIRPMQNINETYNQQQTVSNNTVQWMPSNND------ --------PNISAMEQQQ-FVAELNNTAMSLQNQLKSGSSVTPTKVHGMDLLKHLLSTKPHGNGQSLP------------ -----------MTNAPVQTAKKPQYKRVANVVKDHPSSHHGN--QAITPYVTPNKPEFKPQQSLSQPDVEIEFRKSGLNE MLAEQTTTDVATPLQDPI-----------------------INRTNLISAEQKRRFNIKVGFTRLQSLIPGLTSQT---- -VSKVSKATIMSKAAQYIKTMQNERLKMSEEIQGLKKEVDVLKSAISECQQKLPATGVPVARPPLD---VAKSKFERWVR ERTKRDWKFYLFGLVINPWFDSYQQMVSVTGS------EDLCRSVLEWVDQKCSLPALRPNVVQSLQVLGTTTSILTNP- ANLRQQIEDRVNSDDNTRTRQPT--- >Ciona_savignyi_MLXIPL -------MECSVSQRIQSSRSKPSFTMTRPNNGQ--RKDTHKIDVIHRG----------HSMMSSVTDEGD--------- ----------------EQEEINHDRDSPVHHEQAIMI--------------------------RGHGYDFSNVTKETKNI YQFGPSQ---------SNHITIDSNLARLFKCMSLAYRGGKVVSPKWKNFKGMKLTVKDKIRLNNAIWRTWHIQYVMHRS KVHSLIQFATPLDAEQDHDLHTKPEAVVMEGKYWKRRIETVVAEYKKWRAFFMEKLRLS-----------DYPG------ ---------LTWVTEMENSP---------EHTKE-NRYMDDQTLADFSDTLFSNLSNH-PFQFPNPREIAMHATNSDMIQ PGLLQLQP-MMEDMDFD----PLQDFFAPPKKQ----------------------------------------------- -----------------------------------------------------------------------ISFTNTGFS QNE--NRIAEGWVHNSPNGMRSWENAAPAIEPLQQPEELTVQFTQQQHTRIISQSDPVFSAVNCDTAQ-------NEENV QINQPSAGMVKSFPTQTMFPPKQQITMNTVVNHNPTHVGGSSFNNGQSGFSKISQTQ----------------------- ---LPTDRIIYTQPQTSMQMEFLQTPLHQSTVELKS---------RSILSINENVNQTHQVPNSNIQWLTSNQD------ --------TNYSVLEQQRRFVAELNNTAMSLQTQVNPAPLSQTTVNQGVDLLKQLLCTSIHNTKHMLP------------ -----------VSCITVLVKRLNEAKGHSTMITNQQVTTHVNPAAHISPYISPNKTETK-QGSVVRMDFDTFDKASLLLY FYVSFLLTEQNVSLVEPM-----------------------VNRTSSFSAEQKRRFNIKLGFTRLQGFIPGLTIQS---- -NSKVSKATIMNKAAQYIKTMQTERAKMGEEIIVLKREVDALKGAISECQQKLPATGVPTARPSLD---AAKSKFDSWVR ERSKRDWKFYIFGMVVNPWFDSYQQVVSVAGL------DELCRTVLEWIDQKCSLPALRPSVVQSLQVLGTTTSILQNP- ANLRQQIEEKVNYDNNAGNSR----- >Gallus_gallus_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------DDEDSDYPQ EH--------------------YKESYKDQRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRNAIKKGYDDLQAIVPTCQQQ-DFSI SSQKLSKAIILQKTIDYIQFLHKEKKKQEEEVSTLRKDVMALKIMKVNYEQIVKAHQDNPS----------------EGK DQVSDQVKFNVFQGIMDSLFESFNASISVTSF------QELSACVFSWIEEHCKPHTLRDIVMGVLHQV-KSQLY----- -------------------------- >Xenopus_tropicalis_MLX -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------QKGSLVSRANSIG--STSASSVPNTDDEDSDDRQ ET--------------------IKNDYKDRRRR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKKGYDDLQCIVPTCQQQ-DIAI GTQKLSKAVVLQKTIDYIQFLNKEKKKQEDDVSTLRKEVMALQIMKSNYEQIVKAHQNNLH----------------EGT DQVPDEMKFRVFQGIMDSLFHTFNSSVSVNSF------QELSACVFAWIEEHCKPQTLQDIVIRFLHQL-KNPLY----- -------------------------- >Takifugu_rubripes_MLX_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTDPTTSPEEH-------------------------------- -------------------------WKQTDGAFSDGGFDPS--------------------------------------- ----------------------------------------FFAETSKRATVVSRANSLG--STSASSVPNTDDEDSDYRH ETS-------------------YKDSYKDRRRQ----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKKGYDDLQSIVPTCQQQSEFAM GAQKISKATVLQKTIDYIHFLHKEKKKQEEEVSVLRKEVMALKIMKTNYEHIVKAHQNNPQ----------------QGE NQVSDQIKFSIFQSIMDSLFQSFSTSVSVSSF------QELSACVFSWIEEHCKPQTLKEFVLGVLRQL-NGQLY----- -------------------------- >Oryzias_latipes_MLX_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------G--------------------------------------- ----------------------------------------FYIETARKGSVVSRANSIG--STSASSVPNTDDEDSDYRH ETS-------------------LKDSYKDRRRQ----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------AHTQAEQKRRDAIKKGYDDLQSIVPTCQQQSEFAV GAQKISKATILQKTIDYIHFLHKEKKKQEEEVSVLRKEVMALKIMKTNYEHIVKAHQSNPQ----------------QGE DQVSDQVKFDIFQSIMDSLFVSFSNSVSVSSF------EELSACVFSWIEEHCKPQTLREFVVGVLRQI-NVQLY----- -------------------------- >Monodelphis_domestica_MLXIP ---MAADVFMCSPRRPGGGARPVLLKAPAPDDDDDDSDTDEPAVAATAAAAAPAGSGPSSGPARPRPGPAATAGGPDDDE DDEAEDEEGAPGERRRGRQQIIHSGHFMMSSPHREHP--------------------------PKKGYDFDTVNKQTCQT YSFGKTS---------SCHLSIDASLTKLFECMTLAYSG-KLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKR- -KNPVCHFVTPLDGSVEVDEHRRPEAITTEGKYWKHRIEIVIREYHKWRTYFKKRLQK------------HKDEDLSSLV RDDD----LLFWHKSGDGWDTPVPM---EEDP----LLDTDMLMSEFSDTLFSTLSSHQPMAWPNPREIAHLG-NADMIQ PGLIPLQPNFDFMDTFE----PFQDLFSSSRSI----------------------------------------------- -----------------------------------------------------------------------FGPTLAGPT VSTATDPSSPPAQGPILSAGALPTVSLPDSLIVTPGPASLSPTERRSCERGPRLGGPFIQPTDFGSPEPQLSGPQTFLSV FPGSLLSPSPAPTPSSPAMPLVPSPGATLSAQAPSTFLQSQ-KFE-VGKSSSVITHT----------------------- ---ASATLTHDASATTFSQSQGLVLTAQQPAPPGPPCSLTVPPSVGP-----TQSRLTFVHPKSVPLASGRAKQ------ --------PPKIVPAPKPPEPVSLVLKNAYITPAAFSGQPQAVIVTPGLLKREGVLTSTISQPNVVIA-----RAPGVTE FHSGILVAADLGHATSSQPSPASRLFSPSAVQDSLVKGEQISLHGSSSQMASPSSSRDCPNSGQASPCASEQSPSPQSPQ N-CSGKSATDPPNVAAFK-----------------------NRRMKHISAEQKRRFNIKIGFGTLNSLISNNCKL----- ----TSHAITLQKTVEYIAKLQQERSQMQDEAQRLREEIEELNTTIISCQQQLPATGVPVTRRQYD---HMRDMFDEYVK SRTLQNWKFWIFSIIIKPLFESFKGMVSTTNL------HELHQSALSWLDQHCSLPVLRPMVLLTLRQLSTTTAILTDP- SRLPEQASEAVTR--ISKRTGDSQHP