>Rattus_norvegicus_(Rat)METTL2A(Chromosome_10:_94522903-94536622) ---------------------------------------------------------------MAASLSEGVPETEDRKR PQFG---------------------NRFLSDPARVFHHNAWDNVKWSEEQAAAAERKVQENSSQLVCP----EKQ-ADYE VNAHKYWDDFYKVHENGFFKDRHWLFTEFPELAPSHD--HLVNLHLEKQKNEVSKP-RSSEDGPGLA------AEQHKRP CTSHGCETRVPPVEEPVTQKLTHLEICADDFPGSSATYRILEVGCGVGNTVFPILQT-NNNP------DLFVYCCDFSAT AIELVKTN----------------------SEYDPSRCFAFVHDLCDEDQSYPMPKDSLDVIVLIFVLS----AIVPDKM QKAISKLSRLLKPGGVMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQDELDTLFTAAGLEKVQN------- ----VVDRRLQVNRGKQLTMYRVWIQCKYSKPLVPSASQHVPTPHTT--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Rattus_norvegicus_(Rat)METTL6(Chromosome_16:_6924471-6939562) -------------------------------------------------------------------------------M T---------------------------SLQRKGPQTR------ILSTGEEEKL--KRDQALVSAF--------KQQKLE KEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRS---------------------------------------------- -----------------------------CREYEGQKLTLLEAGCGVGNCLFPLLEEDSNIF---------AYACDFSPR AVDYVKQH----------------------PLYNAERCKVFQCDLTRDDLLDHIPPESVDAVTLIFVLS----AVHPEKM HLVLLNVYKVLKPGRSVLFRDYGLNDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDEFLAKLFVDAGYEEVVN------- ----EYVFRETVNKKEGLCVPRVFLQSKFRKPPKDPAPTTDSASLLRKEF------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Rattus_norvegicus_(Rat)METTL8(Chromosome_3:_53215967-53310093) ----------------------------------------------------MNVIWRNCICRLRQGKVPHRCQSGVHPV APLG---------------------SRILTDPTKVFEHNMWDHMQWSKEEEDEARKKVEENSATRVAP----EEQ-VKFE NAANKYWDTFYQTHKNKFFKNRNWLLREFPEILPVDQNTKEKLGESSWDPARSSIS---------RTQGTETHRQETFVS --SEPGSRERS-ASNPDLEEYSRGPRKAEQFPGSKATFRILEVPCLGDKTGTPVFNQRRNIP------GSFLYCCDFAPE AVELVKSH----------------------EAYSEAHCSAFIHDVCDDGLAYPFPDGTLDVILLVFVLS----SIHPDRM QAVIHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENFYVRGDGTRAYFFTKGEIHRMFCEAGLHEKQN------- ----LVDHRLQVNRKKQIQMHRVWVQGKFQKPSC-WTPRSAD-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Branchiostoma_floridae_(Amphioxus)METTL2AXP_002606144 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------MYCCDFSAT AIDIVKQQ----------------------PDYNTRRCHAFVHDLTDTTSSLPFPPASLDIIIMIFVLS----AIHPDKM QSTVDHLAKYLKPGGKLLFRDYGRYDLAQLRFKKGRCLSDNFYVRGDGTRVYFFTQDELRTLFGSAGLQEELI------- ----HVDRRLQVNRGRQVKMYRVWLLCKFTKPLD---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Caenorhabditis_elegans_(Nematode)METTL2A(Chromosome_II:_14969826-14970843) ------------------------------------------------------------MKDEPIMACAEENPDEKPKC NPFG---------------------TRFLTDDTKVFEHNAWDDVEWSPEQQEEAQRIVQGQKSMKVDE----EKA-MRLL STPADQWDAFYAHNENRFFKDRNWLLKEFPELNVEDESNLQKE------------------------------------- ------------------------------------KIEILEVGCGVGNTTFPLLQVNNSSS------RLMLHSCDYAPN AIRVLKSQ----------------------DAYDPEKMNAFVWDITQPASQEAPNVGSLDYIVCIYVLS----AIHPDNI KNALKNLVRLLKPGGSLLLKDYGRYDLTQLRFKKDRLIDGNLYCRGDGTLVYFFDMEELETLLAEHGLQKKVM------- ----HVDRRLIVNRAKQVKMYRQWIQGKFLKSC----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gallus_gallus_(Chicken)METTL6(Chromosome_2:_41408897-41416546) ------------------------------------------------------------MFHENTSADCLSTLTTSTED G---------------------------AFQTKGHNTR------ILSPEEAERL--ANDRVLVSDF--------KQLKLE KEAQKNWDLFYKRNSTNFFKDRHWTTREFQELKA---------------------------------------------- -----------------------------CREFADQKLTILEAGCGVGNCLFPLLEEDLNIF---------AYACDFSPR AVEYVKKN----------------------SLYSTERCKVFQCDLTKDDLLENIPADSVDVVTLIFVLS----AIHPDKM HLVLKNIYKVLKPGKCVLFRDYGLYDHAMLRFKSGSKLGENFYVRQDGTRSYFFTTEFLSQLFRAEGYEEVVN------- ----EYVHRETVNRKEDLRVPRVFLQSKFQKPFSKT-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Pan_troglodytes(Chimpanzee)METTL2A(Chromosome_7:_130011295-130036200) ---------------------------------------------------------------MAGSYPEGAPAVLADKR QQFG---------------------SRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQ----EKQ-VDYE INAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK-SEVCEC-RNNEDGPGLIM-----EEQHKCS LKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDP------GLFVYCCDFSST AIELVQTN----------------------SEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLS----AIVPDKM QKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEEPDMLFTTAGLEKVQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Pan_troglodytes(Chimpanzee)METTL6(Chromosome_3:_15646373-15664404) -------------------------------------------------------------------------------M A---------------------------SLQRKGLQAR------ILTSEDEEKL--KRDQTLVSDF--------KQQKLE QEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRS---------------------------------------------- -----------------------------CREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIF---------AYACDFSPR AIEYVKQN----------------------PLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLS----AVHPDKM HLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVN------- ----EYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Pan_troglodytes(Chimpanzee)METTL8(Chromosome_2B:_175759018-175871341) ----------------------------------------------------MNMIWRNSISCLRLGKVPRRYQSGYHPV APLG---------------------SRILTDPAKVFEHNMWDHMQWSKEEEAAARKKVKENSAVRVLL----EEQ-VKYE REASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNCFSRMHCPTVPDEKNHYEKSSGS --SEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLQNSP------ESFLYCCDFASG AVELVKSH----------------------SSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLS----SIHPDRM QGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQN------- ----LVDRRLQVNRKKQVKMHRVWIQGKFQKPLH-QTQNSSDMVSTLLSQD----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Ciona_intestinalis_(Ascidian)METTL2A(Chromosome_7:_5903036-5903995) --------------------------------------------------------------------------MDDTKR PTFG---------------------NRFLKDDAQVFLHNAWDNVEWTEEQESNARQITTAQAENSMPD----EEQ-EKFL SEAPKFWDKFYEKHENKFFKDRHWLFTEFPELLLVKESKDNEELLCNDDTNDGELL------------------SNNETT VGS---------------------------FPGSDSKVKFMEIGCGVGNTIFPILKV-NNE-------NLFMYGCDYSQT AVDIVKNH----------------------KEFNPKSAFVFVHDISTED-EFPIPNESLDVVIMIFVLS----ALQFRKM GGAVKRIAKLLKPGGVILFRDYGRYDMAQLRFKHRRCISDNFYTRGDGTMVYFFTQGEVKEIFTSAGLMEEQN------- ----LVDRRLQVNRARQIKMYRVWVQAKYRK------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Ciona_intestinalis_(Ascidian)METTL6(Chromosome_8:_3731993-3734341) --------------------------------------------------------------------------MEDFES K----------------------------SQYTSSQVR------SLSDDELQMLENQNKR-LVTEF--------RSQKLE VEAKKMWDLFYKRNTTNFFKDRHWTSREFGEIEQ---------------------------------------------- ------------------------------RIHNNQQTVLLEAGCGVGNAIFPLMAQAKDLF---------VYACDFSPR AVELVKDN----------------------PSYSETKCKAFQCDLGTDHLSYTIQENSVDLVTLIFVLS----AIHPDKF EFVLRNIHKVLKPGGYLLFRDYGLNDWAMLRFNNGSKISENFYVRQDGTRAYYFKKEELESLTCASGFDVVSN------- ----EYVMRETINKKKNLKVPRVFLQGKYQKP------------------APT--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Ciona_savignyi_(Ascidian)METTL2A(reftig_65:_492611-495552) ------------------------------------------------------------------------------ES -----------------------------SQWTTEEVR------PLTAEEKVMLEKQVSL-LVSDF--------RRDKLE LEARKMWDLFYKRNSVNFFKDRHWTTREFNEIEE---------------------------------------------- ------------------------------RIKSNEHTVLLEAGCGVGNAIFPLMDKYSNLF---------VYACDFSPR AVQHVKDN----------------------PGFSKKNCNAFQCDISTQSLCDNIQENSVDLVTLIFVLS----AIHPNKF EFVFENIHKVLKPGGYLLFRDYGLNDWAMLRFSTGSKIAENFYVRQDGTRAYYFKKGELENLASSNGFLVSSN------- ----EYVMRETVNKKKNLKVPRVFLQGKYQK------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Bos_taurus_(Cow)METTL2A(Chromosome_19:_47512361-47523553) ---------------------------------------------------------------MDCSFPEGDPAAVCGKR QQFG---------------------SRFLSDPARVFHHNAWDNVEWSEEQAAEAERKVQENSTQRVCQ----EKQ-ADYE INANKYWNNFYKIHENGFFKDRHWLFTEFPELAPSQN--HLKNLLSENKRSEVYEYYRSGEDGPDLTI-----EEQHRCS SVSLGDKTQPPLTEESVTQKLHHLEICANEFPGSSATYRILEVGCGVGNTVFPILQT-NNDP------SLFVYCCDFSST AVELVQTN----------------------SAYDPSRCFAFVHDLCDEDKSYPMPENSLDVIILIFVLS----AIVPDKM QNAINRLSRLLKPGGIMLLRDYGRYDMAQLRFKKGQCLSENFYVRGDGTRVYFFTQDELDTLFTTAGLEKVQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYRKPLGSSTG------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Bos_taurus_(Cow)METTL6(Chromosome_1:_154171377-154187728) -------------------------------------------------------------------------------M A---------------------------ALQRRGLQTR------ILSSEEEEKL--KRDQALVSDF--------KQQKLE KEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRS---------------------------------------------- -----------------------------CREFEDQKLTILEAGCGVGNCLFPLLEEDPDIF---------AYACDFSPR AVEYVKQN----------------------PLYDTERCKVFQCDLTKDDLLEHVPPESVDVVTLIFVLS----AVHPDKM HLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKAGSKLAENFYVRQDGTRSYFFTDEFLARLFLDTGYEEEVN------- ----EYVFRETVNKKEGLCVPRVFLQSKFRKSQKNPIPVTPDLGHES--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Bos_taurus_(Cow)METTL8(Chromosome_2:_25117252-25154865) ----------------------------------------------------MNVIWRNYISCPRMRKVPHRYQSGCHPV APLG---------------------SRILTDPTKVFEHNMWDNLEWCTEDLALSRRKVYDNTAIRIIQ----NES-LKYE SEASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVGQKTEEKVKELSWNHVKINAESFFSKMHCPTMPEEKNHYKESSGS --SDGQSKAGSDFSKLDSEEYRERPLKTELFPGSNAAFRILEVGCGAGNSVFPILNTLQNVP------EFFLYCCDFASG AVELVKSH----------------------ASYRAAQCCAFVHDVCDHGLPYPFPDGTLDVILLVFVLS----SIHPDRM QGVINRLSKLLKPGGMLLFRDYGRYDKTQLRFKRGHCLSENFYVRGDGTRAYFFTKGEVHNMFCKAGLDEKQN------- ----LVDRRLQVNRKKKVKMHRVWVQGKFQKPLH-LTQKSSNLVFSVLSHE----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Loxodonta_Africana_(Elephant)METTL2A(SuperContig_scaffold_31:_28391051-28405232) ------------------------------------------------------------------RALKSPLRVPNGKR EQFG---------------------SRFLSDPARVFHHNAWDNVEWSEEQAAAAEKKVRENSAQRMPQ----EKQ-VDYE INAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKGLLSEDKKSEIPEY-RSSEDGPGLTT-----EEQHKSS SSSRRDKTQAPSVKN-ITQKLSHLGICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDP------GLFVYCCDFSST AVELVQTN----------------------SEYDPSRCLAFVHDLCDEDQSYPMPRDSLDIIILVFVLS----AVAPDKM QKAVNRLSRLLRPGGMMLLRDYGRYDMAQLRFKKGQCLSENFYVRGDGTRVYFFTQDELDTLFTAAGLEKVQN------- ----LVDHRLQVNRGKQLTMYRVWIQCKYRKPL----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Loxodonta_Africana_(Elephant)METTL6(SuperContig_scaffold_103:_683898-701765) -------------------------------------------------------------------------------M A---------------------------SLQRKGLQAR------MLSSEEEEKL--KRDQALVSDF--------KQQKLE KEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRS---------------------------------------------- -----------------------------CREFEDEKLTVLEAGCGVGNCLFPLLEEDLNIF---------AYACDFSPR AVEYVKQN----------------------PSYNTERCKVFQCDLTKDDLLEHVPSESVDVVMLIFVLS----AIHPDRM QLVLQNVYKVLKPGKCVLFRDYGLYDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDEFLAQLFTDTGYEEVIN------- ----EYVFRETVNKKEGLCVPRVFLQSKFRKPPKHPAPTSPGPGPESQVL------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Loxodonta_Africana_(Elephant)METTL8(SuperContig_scaffold_3:_55821628-55866082) ----------------------------------------------------MNVIWRNSISCLKIGKAPHRYQSDYRPT APLG---------------------SRILTDPTKVFEHNMWDHMQWSKEEEEAARKKVEENSAVRVLL----KEQEIHFH FSALKYRSIFYKIHKNKFFKDRNWLLREFPEILPVDQKTTEKVGELSWDHVKTNTANCFSRMHCPTMPEGKNHYKKNPGS --SNGRSKAESDFSKPDSEEHRKGPLKTDLFPGSNATFRILEVGCGAGNSVFPILNILQNVP------GSFLYCCDFASG AVDLVKSH----------------------SSYRAAQCSAFVHDVCDDGLPYPFPDGILDVILLVFVLS----SIHPDSF S---------------------------------------------------FF-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Drosophila_melanogaster_(Fruit_fly)METTL2A(Chromosome_3L:_1637942-1639231) ---------------------------------------------MLTTSSSTMLGKYGWQILRRLASKSWEHTRQRKKP SGAG---------------------SRVLTDAREVFEFNAWDHVQWDEEQELAAKAAVAKNSTSKMEA----EQK-ERFQ TDAPKFWDSFYGIHDNRFFKDRHWLFTEFPELAPLAADSAVLQ------------------------------------- ------------------------------------PRSIFELGCGVGNTILPLLQY-SSEP------QLKVFGCDFSAR AIEILRSQ----------------------RQFDEKRCEVFVMDATLDHWQVPFEENSQDIIVMIFVLS----AIEPKKM QRVLDNCYRYLRPGGLLLFRDYGRYDLAQLRFKSGKCMEDNFYVRGDGTMVYFFTEEELRGMMTQAGLQEEQL------- ----IVDRRLQVNRCRGLKMYRVWIQTKFRKPL----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Drosophila_melanogaster_(Fruit_fly)METTL6(Chromosome_2R:_13620760-13621988) --------------------------------------------------------------------------MEPLEP ------------------------------DVITTQAK------ELSAVERQKLDEQNKRGLVPEY--------KANKLE IDAQRNWDIFYKRNETRFFKDRHWTTREFQELLD---------------------------------------------- ------------------------------QEEFHEKRTLFEVGCGVGNLVFPLLEEQTSEEGCFSNSRFFFYACDFSPR AVEFVRSN----------------------PLYDPSQISAFQCDITTQQVHDHIPPSSVDICTLIFVLS----AIHPQKF KDVVQNLGKLLKPGGLLLFRDYGLYDMAQLRFKPGNKIAENLYVRQDGTRSYFFSEEEVSKLFQENGFEVITN------- ----AYVHRRTLNLKEGVDVPRIFLQGKFRR-------------------KNL--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Takifugu_rubripes_(Fugu)METTL2A(scaffold_15:_1743932-1746233) -----------------------------------------------MAAPHAAVA--GEAGSGDTELSLASSISEDGKR PQFG---------------------TRFLTDPRQVFQHNAWDNVEWTEEQEASAKKKVLENC-QPLPS----EKQ-EEYE NRANEYWNDFYTIHENRFFKDRHWLFTEFPELCPQCSPNNVTHQKVSSTGRCVQDE-----------------ERAKQGA AVS-PINVN---------------------FPGATASYRILEVGCGVGNTVFPILKT-NNDP------ELFVYCCDFSST AVDLVKTN----------------------PEYNLGRCFAFVHDLSDVEANYPIPDGTLDVIVLIFVLS----ALHPIKM QASISRLARLLKPGGVMLLRDYGRYDMAQLRFKKGRCLSDNFYVRGDGTRVYFFTQEELHSMFTEAGLEKVQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYHKP--LVPS------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Takifugu_rubripes_(Fugu)METTL6a_(scaffold_290:_14351-16248) ------------------------------------------------------------------------KESESISS V---------------------------LGQDTKATNR------VLTQEEMDKL--DGE-VLVSDF--------KQIKLE KEAQKNWDLFYKRNSTNFFKDRHWTTREFEELKA---------------------------------------------- -----------------------------CREFASQQLVLLEAGCGVGNCIFPLLDDELNIF---------VYACDFSPR AVEFVSKN----------------------PLYSPERCCAFQCDLTKDDLRENVPEGSVDVITLIFVLS----AVHPDKM KLVLQNISRVLKPGGIALFRDYGLHDHAMLRFKSGSKLGENFYVRQDGTRSYFFSK------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gorilla_gorilla_(Gorilla)METTL6_(Chromosome_3:_15849005-15864866) -------------------------------------------------------------------------------M A---------------------------SLQRIGLQAR------ILTSEEEETL--KRDQTLVSDF--------KQQKLE QEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRS---------------------------------------------- -----------------------------CREFEDQKLTMLEAGCGVGNCLFPLLEEDSNIF---------AYACDFSPR AIEYVKQN----------------------PLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLS----AVHPDKM HLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVN------- ----EYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Apis_mellifera_(Honey_bee)METTL2AXP_624474 ---------------------------------------------------------------MEEDISKHQQNESNNKR PQFG---------------------NRILSNNNNVFQHNAWDNIIWDEEQQNLAKQKVNENSTITMSD----EKI-WEYE HEAYKYWDKFYGIHENKFFKDRHWLFTEFPELAVDIVKQNIKQP---------------------------------LRF KNENIKK------------NGQETHENILDLPSKNGNK-ILEIGCGVGNTVFPILLY-NTDA------NLFVYCCDFSAK ALDILKQN----------------------SAYDTSRCKAFILDVTQEEWETPFEPESLDIIVLIFVLS----AINPEKM KHIIEQIHKYLKSGGLVLFRDYGRYDLAQLRFKKGSCLANNFYVRGDGTRVYFFTQEEIRILFTSCGFIEEQN------- ----LIDRRLQINRGKQLKMYRVWIQGKYRK------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Apis_mellifera_(Honey_bee)METTL6XP_623532 -------------------------------------------------------------------------MAESMKS ------------------------------EYASHVAK------QLTEEEIVKMRAQNSR-LVSEF--------RANQLE KDAKKHWDLFYKRNDTRFFKDRHWTTREFDELLN---------------------------------------------- ------------------------------LNTKNEQNVLFEVGCGVGNFVYPLIEDGLKFK--------MIFACDLSSR AVELTKNH----------------------SLYDPENMKIFQTDITTENCFLEVN-YPVNIATLIFVLS----AIHPKKF RKVVENLYNVLDKGGIVLFRDYGLYDMAQLRFKPGHKISENLYMRQDGTRTYYFSEKEVSNLFRSVGFEVLTC------- ----HYVQRRTVNFKEKIDVPRIFVQGKFVKPPRHPRPPPLPPLDDSMLGRNTFGCEGGGALVPTRGDSPSPRPFFHHVR GDLYIKALFWVAKASETTISLTYPVPYLTDKQLAYRNNTLFRINMRSLVILVLVAVAISRVSCRELKGDKRSSRLPLKGK RGIVDYSGGSSYNSPLISSGYTGGYSSAHSPSIPSIQSLGGGTMGYSLGSGGLGHNFGISLGGQHFGGAQSYSSPGLGSL AGGGGLFSPPSKNGPVTFGIHGGGGSSSSTSYSAPVYATGVHGLSSYGSGSSHQGISLSSMLGSGHSYGLPASSLGSGHA LSMIHSISPGYAASGGLVIDSSSLGKGSSSYSLPLSSSHGSSSLSTGSSSSYALPVSSGSSHSGISALHSGSTASYSLPV SSGSSIGGHISFSGGSSADSYSLPASSISASHPYVTVMSDASSSSSGSSSYSSPSSSYSAPASGSISSYSSPASSYSSSG YSGTSSSYSPIYSAPSTSYGTPMESHGSYSNLAARYVEYPGSKSYEDSTSSNKYDTISYSSPSGKY >Hydra_magnipapillata_(Hydra)METTL2AXP_002156347 ------------------------------------------------------------------------MIFENEVY G---------------------------FST-------KDDQILSEVELKKLAC--DRN--LVSNY--------KQIQLE INAQKNWDLFYKRNSTKFFKDRHWTTREFDEITS---------------------------------------------- -----------------------------EKLNDKK---LLEVGCGCGNAIFPLIEENKNIF---------VYACDFSSR AIEYVKAH----------------------KLYELSRCLAFQSDVTKDNLCSFVPEASIDIALMIFVLS----AVHPDKM KEVLQNVHRVLKPGGIVLFRDYGLYDHAMLRFGPGHKLDDRFYVRQDGTRAYYFSTDKLFELFTSCGYEVVEN------- ----TYIHRRTINKKEGIDVPRIFVQGKFTKLS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Hydra_magnipapillata_(Hydra)METTL8XP_00216525 ----------------------------MDIVTTGVANGKSKQRVVLGESVSSWVDIVSGVPQGSVLGPILFLIYINDLL S---------------------------QLTNQLLLYADDCKVIALSRLSKMQT--VNCPAIEEGYSDSSGVADKQIQLE INAQKNWDLFYKRNSTKFFKDRHWTTREFDEITS---------------------------------------------- -----------------------------QKLNDKK---LLEVGCGCGNAIFPLIEENKNIF---------VYACDFSSR AIEYVKAH----------------------KLYELSRCLAFQSDVTKDNLCSFVPEASIDIALMIFVLS----AVHPGKM KEVLQNVHRVLKPGGIVLFRDYGLYDHAMLRFGPGHKLDDRFYVRQDGTRAYYFSTDKLFELFTSCGYEVVEN------- ----TYIHRRTINKKEGIDVPRIFVQGKFTKLS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Anolis_carolinensis_(Lizard)METTL6(Chromosome_6:_36445680-36453110) -------------------------------------------------------------------------------S G---------------------------GFPKRGHKMR------TLSPEEAERL--AKDPVVVSDF--------KQQKLE KEAQRNWDLFYKRNSTNFFKDRHWTTREFEELKA---------------------------------------------- -----------------------------CREFDDQKLTILEAGCGVGNCLFPLLEEDLNIF---------AYACDFSPR AVEYVKQN----------------------PLYDPQRCKVFQCDLTKDDLLENVPPDSVDVATLIFVLS----AIHPEKM HLVLCNIYKVLKPGKCVLFRDYGLYDHAMLRFKSANKLGENFYVRQDGTRSYFFSDDFLAELFLSAGYKQVVN------- ----EYVLRETVNKKEGLCVPRVFLQSKFQKPHKE--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Macaca_mulatta_(Macaque)(Chromosome_16:_57929156-57956471) ---------------------------------------------------------------MAGSYPEGAPAVLADKR QQFG---------------------NRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSTQRVCQ----EKQ-VDYE INAHKYWNNFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKRSEVPEC-RNNEDGPSLIM-----EEQHKCS SKSLEHKTETPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDP------GLFVYCCDFSST AIELVQTN----------------------PEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLS----AIVPDKM QKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDMLFTTAGLEKVQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Macaca_mulatta_(Macaque)METTL6(Chromosome_2:_157739948-157757392) -------------------------------------------------------------------------------M T---------------------------SLPRKRLQAR------VLSSEEEEKL--KRDQTLVSDF--------KQHKLE QEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRS---------------------------------------------- -----------------------------CREFEDQKLTILEAGCGVGNCLFPLLEEDPNIF---------AYACDFSPR AVEYVKQN----------------------PLYDTERCKVFQCDLTKDDLLDHVPPGSVDVVMLIFVLS----AVHPEKM HLVLENIYKVLKPGKSVLFRDYGLYDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDEFLAQLFMDTGYEEVVN------- ----EYVFRETVNKKEGL-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Macaca_mulatta_(Macaque)METTL8(Chromosome_12:_35007353-35016039) -------------------------------------------------------------------------------- ----------------------------------------------------------------------------VKYE REASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDLVNTSATNCFSRMHCPTMPEEKNHYEKSSGS --SEGQSKTESDFSNLD-----------GLFPGSNATFRILEVGCGAGNSVFPILNTLQNSP------ESFLYCCDFASG AGELIKSH----------------------SSYRAAQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLS----SIHPDR- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Oryzias_latipes_(Medaka)METTL2A(Chromosome_8:_5685381-5687945) -----------------------------------------------MEAPCAVDA--VAAGSSETGHSLSGSSSAESRR PQFG---------------------TRFLTDPKQVFQHNAWDNVEWTDEQEEAAKRKVSENS-YPLPA----EKQ-EEYD SRANEYWNEFYTIHENRFFKDRHWLFTEFPELAPQCSVLNHTS-HIDEPQGSNLDQ-----------------NRCRDSG AED---SRD---------------------FPGSSASYRILEVGCGVGNTVFPILKT-NNDP------GLFVYCCDFSST AVELVKNN----------------------PEYDPGRCFAFVQDLSDADASYPIPDGSLDVIVLIFVLS----ALHPDKM QASIRRLARLLKPGGMILLRDYGRYDMAQLRFKKGRCLSENFYVRGDGTRVYFFTQDELHELFTRAELEKVQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYKKAS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Oryzias_latipes_(Medaka)METTL6(Chromosome_16:_23610188-23614347) ----------------------------------------------------------------MNRAEDTESTDDTPTC L---------------------------SGQTKTSSSR------DLTQEEQGRF--KTERVLVSEF--------KQIKLE KEARKNWDLFYKRNATNFFKDRHWTTREFEELKE---------------------------------------------- -----------------------------CREFESQKLVLLEAGCGVGNCLFPLLEDDLNIF---------VYACDFSPR AVEFVKQN----------------------PLYCPERCCAFQCDLTKDDLTGNVPEGSVDVVTLIFVLS----AVHPEKM KLALENINKVLKPGGVVLFRDYGLHDHAMLRFKAGSKLGENFYVRQDGTRSYFFSKEHLAQLFKEAGFVSVVN------- ----DYVLRETVNKKEGLCVQRVFLQSKFTKAALPQVSCSPVFPGSGK-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Oryzias_latipes_(Medaka)METTL8(Chromosome_21:_23977170-23980133) ---------------------------------------------------------------LAPSFAVKFKNTKPRPV APLG---------------------SRILTNTDDIFKHNMWDHIKWTVEDKENARQKVQENSSVQIPA----PER-GKFD AEACQFWDKFYEVHQSKFFKDRRWLFLEFPELLHPSHRENRVTN-VHHEHKVIQIQSGCT-------ADTEKRHYQHNDP TGGSWKIN------NWNYQEAQQELKDVPSFLGHDASFRILEVGCGVGNSVFPILNNIRNT-------DSFLYCCDFSAR AIQMVQDH----------------------QDYDKSICHAFVHDICEEGSSFPFPPQSLDVILAVFVLS----SIHPERL QGVVNRLSSYLKPGGMFLFRDYGRYDFSQLRFKKGRCLSDHFYTRGDGTCVYYFTEEEVGDLFSKAGLEEIQN------- ----LEDRRLQVNRKKKVAMRRVWIQSKFRKPSLHFLPEHSP-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Anopheles_gambiae_(Mosquito)METTL2AXP_316017 ---------------------------------------------MTETTEETIP---------------TDQSEQPSVR PQFG---------------------NRFLSAGDDVFQHNAWDNVQWDEEQENAALEGVKKNSSVKLSD----AEV-TRLE TEADQNWDRFYGIHQNRFFKDRHWLFTEFPELAPAKGPNTVPERVLPDGE------------------------------ -------------------PVKRAEEVSQESDGQQRSRTIFEIGCGVGNTVFPILKY-SEEK------NLMIYASDFSRQ AIDIMCQS----------------------PEYDTNRCKAFVLDATADRWDVPFAENSIDIVVLIFVLS----AIDPERM QHVVNQIARYLKPGGMVMLRDYGRYDLAQLRFKPGKCLKDNFYVRGDGTLVYFFTQEDLRTLFTSAGLVEEQN------- ----IVDRRLQVNRGKMVKMYRVWVQVKFRKPTDN--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Anopheles_gambiae_(Mosquito)METTL6XP_318925 ------------------------------------------------QVELTSHPRLAYRHTQFSKGFSTPKQSLSFKS EPSFCRYEKSKQPRSLAKGTNGTQKAFNLGDVVTDAAK------ILTEEERTKLEEQNKR-LVTPF--------QALKLE QEARKHWDLFYKRNENRFFKDRHWTTREFSELLAGED------------------------------------------- ---------------PAAAASSSPLAKPDNVERISVEKKLLEIGCGVGNLIFPLIEDGHRDY--------FIYACDLSPR AVELVQKH----------------------NLYDERYMKAFACDITTEEVFQTLPEASLDIVTLIFVLS----AIHPEKF QSTVANIYRLLKPGGVVLFRDYGLYDMAQLRFKPGHKIAENFYMRQDGTRSYYFAEEEVSKLFCQTGFTVMVN------- ----SYIHRRTVNPKENIDVPRIFVQGKFLKP------------------EQT--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Mus_musculus_(Mouse)METTL2A(Chromosome_11:_105126425-105140394) ---------------------------------------------------------------MAASFPEGVPETEDGKR PQFG---------------------HRFLSDPARVFHHNAWDNVKWSEEQAAAAERKVQENSSPLVCP----EKQ-VDYE VNAHKYWDDFYRIHENGFFKDRHWLFTEFPELAPSHS--HLTGVPLEKQRSDVC------EDGPGLT------AEQHKCS CASPGCETQVPPLEEPVTQKLGHLEISGEEFPGSSATYRILEVGCGVGNTVFPILQT-NNNP------NLFVYCCDFSAT AIELLKTN----------------------SQYDPSRCYAFVHDLCDEDQSYPVPEDSLDVIVLIFVLS----AIVPDKM QKAISKLSRLLKPGGVMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQGELDTLFTAAGLEKVQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYSKPLALRSSQHVPIPHATESSSHSGLL------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Mus_musculus_(Mouse)METTL6(Chromosome_14:_31478320-31495030) -------------------------------------------------------------------------------M A---------------------------SFQRKGLQAR------ILSTEEEEKL--KRDQALVSAF--------KQQKLE KEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRS---------------------------------------------- -----------------------------CREYEGQKLTLLEAGCGVGNCLFPLLEEDLNLF---------AYACDFSPR AVDYVKQH----------------------PLYNAERCKVFQCDLTRDDLLDHVPPESVDAVTLIFVLS----AVHPEKM RLVLLNVYKVLKPGRSVLFRDYGLNDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDEFLAQLFVDAGYEEVVN------- ----EYVFRETVNKKEGLCVPRVFLQSKFRKPPKDPAPTSDSASL----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Mus_musculus_(Mouse)METTL8(Chromosome_2:_70964561-71055583) ----------------------------------------------------MNVIWRSCICRLRQGKVPHRCQSGVHPV APLG---------------------SRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAP----EEQ-VKFE SDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSIS---------RTQGTETHCQESFVS --PEPGSRGRS-APDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIP------GSFLYCCDFASE AVELVKSH----------------------ESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLS----SIHPDRM QAVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENFYVRGDGTRAYFFTKGEIRRMFCEAGLHEKQN------- ----LVDHRLQVNRKKQVQMHRVWIQGKFQKPSP-WTPQSGN-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Nematostella_vectensis_(Sea_anemone)METTL2AXP_001637965 -------------------------------------------------------------------------MAEGKDI R---------------------------DIQNETESSIQGLYPRVLTDEEKQKL--ERDTSCISEF--------KRNKLE QDARKNWDLFYKRNSTNFFKDRRWTTREFTELLN---------------------------------------------- -----------------------------VEDEKLNEKVLLEAGCGVGNLINPLLEEGYNFY---------FHACDFSPR AVNFVKES----------------------PFYDEAKVNAFQCDLTKDDLLENIPACSVDIATLIFVLS----AIHPDKM ITALLNIFKVLKPGGLLLLRDYGLYDHAMLRFAPGHKLSEQFYVRQDGTRAFYFSQDDLEVLFKKAGFVVLMN------- ----KYVEKRTVNKKENIDVPRIFVQGKFMKPES---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Monodelphis_domestica_(Opossum)METTL2A(Chromosome_2:_208905141-208932130) ---------------------------------------------------------------MADSCPESVSATTRDKR VQFG---------------------NRFLNDPARVFQHNAWDNVEWSEEQEAEAERRVRENSAQRVPP----EKQ-VDYE VNAHKYWNNFYKIHENGFFKDRHWLFTEFPELTPNQNKSNLKNLLLKDGDFEIIEH-RNSGNGLGLIVSNT--QEQHKAS SHSVDDKEQKHPIEE-TTQNTCHLDINTDGFPGSSATYRILEVGCGVGNTVFPILHT-NNDP------GLFVYCCDFSTT AVDLVQTN----------------------SEYDPSRCFAFVHDLCDEEKSYPMPRESLDVIILIFVLS----SIVPDKM QNAITRLSYLLKPGGMILLRDYGRYDMAQLRFKTGRCLSENFYVRGDGTRVYFFTQDELDTLFTTAGLEKVQN------- ----MVDHRLQVNRGKQLTMYRVWIQCKYRKPFSPNIS------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Monodelphis_domestica_(Opossum)METTL8(Chromosome_4:_181416514-181490560) ----------------------------------------------------MNAIQRLWASSLRKRRMWVRFQSNDRPA VPLG---------------------SRILADPAKVYEHNMWDHMEWSQEEEEAAREKTTENSSVRVQL----EDQ-VKYE NQASKYWNNFYEIHKNKFFKDRNWLLREFPEILPVGLQTKEEKEKMSWDCVKTDPTDSFLKTDCLAVPKRIESYKNDFGD NFTYSQSKIRS-SDSQHPNKKKEEAAKTKLFPGSCATFRILEVGCGAGNSVFPILNALKNAP------ETFLYCCDFASE AVELVKSH----------------------SSYSPAQCSAFVHDVCDDGLSYPFPDGILDVILLVFVLS----SIHPDRM QGVVNRLSKLLKPGGMLLFRDHGRYDFTQLRFKKGYCLSENFYVRGDGTRAYFFTKGEVHNMFHQAGLDEKQN------- ----LVDRRLQVNRKKKVKMYRVWVQGKFQKPLHSFHHNHSDNCIPGISAG----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Strongylocentrotus_purpuratus_(Sea_urchin)METTL2AXP_780030 MILGCHFLKHGLALGSKIIRHRKGFSTSVHAYQVRGDENLHVKELLEERNHQYPSSDSGKIMSAGEELPVTKDDAASVKR PQFG---------------------NRFLENPDNVFQHNAWDNVAWDPEQLEAAKKKVGENSSQQVET----EKK-ELYE ADADRYWNEFYSLHQHKFFKDRHWLFTEFPELSSDNAQASAKECSSERGASQETSE-PRTMDSLTTGGSNT--SAEATER KNEDCEHGPTSSRTSRSESGTDEIHAASDDFPGKSAHKRILEVGCGVGNTIFPILQT-NADP------GLFVYGCDFSSV AVDIVRQH----------------------AEYNPSRCHAFVCDVSDPAASFPVPDNSLDLVVLIFVMS----AINPDRF LSTIQTLTRLLKPGGRILFRDYGRYDLAQLRFKKGRCLSENFYVRGDGTRVYFFTQDELRELFISAGLVEEQN------- ----TIDKRLQVNRGRQLTMYRVWIQCKYRKP------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Strongylocentrotus_purpuratus_(Sea_urchin)METTL6XP_794407 -------------------------------------------------------------------------MEKEKDG G---------------------------GWVTTKQ-------PRDLTEAEKQKL--AEDETCVSDF--------KQNKLE LEAKKNWDLFYKRNSTNFFKDRHWTTREFEELI----------------------------------------------- -----------------------------AESREGKQKSLLEVGCGVGNTVYPLLDASPEIF---------IHCCDFSPR AVQFVKEH----------------------SAYDPARVNAFQCDITCDDLTNNIAASSVDMVTMFFVLS----AIHPDKM LQSIQNIYKALCPGGLVLFRDYGLHDHAMLRFSKGHKLSENFYVRQDGTRAFYFSTDVLSDLFIKAGFDVVVN------- ----EYVYRETVNKKEGLSVPRVFVQSKFSKKIAENS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gasterosteus_aculeatus_(Stickleback)METTL6(scaffold_122:_13517-15684) -------------------------------------------------MALSQRGRFPGESEASHPKEDVGSNGELPPR L---------------------------PGRNQSSTAES-----VPPRGERDGL--GGSAAPASGF--------RLRKLE EEAQKNWDLFYKRNTTNFFKDRHWTTREFQELQA---------------------------------------------- -----------------------------CRELEAQRLVLLEAGCGVGNCLFPLLEDDRDVF---------VYACDFSPR AVDLVKKN----------------------PLYTPERCCAFQCDLTKDDLRTQVPEGGVDVVTLIFVLS----AVHPDKM QLVLQNISRVLKPGGVVLFRDYGLNDHAMLRFKARSKLGENFYVRQDGTRSYFFSKELLAELFAGAGLQSVSN------- ----DYVLRETVNKKEGLCVPRVFLQSKFTKPGQSQGC------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gasterosteus_aculeatus_(Stickleback)METTL8(groupXVI:_10271231-10276592) ----------------------------------------------------MHQLQSFSVAKVLSRLSSRLHSTRGRPS APLG---------------------SRILTKNDDIFKHNMWDHVQWTEEEKENARQKAKENSSTQIPL----KEQ-GTFD TEACQYWDKFYQMHQERFFKDRKWLFLEFPELLPYGAKGQNANGRLGDQQASHPRPTGSSP------TDTETRLQQPNGP THHHRNTT--PPDHQGAAPEKNKAPKQTPTFPGQQSSFRILEVGCGVGNSVFPILSSIKET-------DAYLYCCDFSPC AIQLVKDH----------------------PDYSDSMCHAFVHDICEE-ASFPFPPKSLDVILAVFVLS----SIHPERT QGIVKRLSTYLKHGGIFLFRDYGRYDFSQLRFKKGRCLSENFYTRGDGTCVYFFTKGEVHDLFSSAGLEEIQN------- ----LEDRRLQVNRGKKVAMHRVWMQSKYRKL------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Tetraodon_nigroviridis_(Tetraodon)METTL2A(Chromosome_3:_13418764-13421503) -----------------------------------------------MAAPDAVAG--VEAGGGDTDLALASSITEDGKR PQFG---------------------TRFLTDPRQVFQHNAWDNVEWTEEQEASAKKKVLENS-QPLPS----EKQ-EEYE NRANEYWNEFYTIHENRFFKDRHWLFTEFPELCPQWN-SSVNDQEVSSTGAGFLDE-----------------EQTKKIT AVPHIINAH---------------------FPGATASYRILEVGCGVGNTVFPILKT-NNDP------DLFVYCCDFSST AVDLVKTN----------------------PEYDPGRCFAFVHDLGDVEADYPVPNGTLDVIVLIFVLS----ALHPNKM QASISRLSQLLKPGGVMLLRDYGRYDMAQLRFKKGRCLSDNFYVRGDGTRVYFFTQDELHSIFTGAGLEKVQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYRKPPAAIPDAVEGGTEHNHN------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Tetraodon_nigroviridis_(Tetraodon)METTL6(Chromosome_Un_random:_34558737-34560227) -------------------------------------------------------------------------------M C---------------------------RFEKQSIRNR------VLTQEEMDKL--GAE-VLVSDF--------KQIKLE EEAQKNWDLFYKRNTTNFFKDRHWTTREFEELKA---------------------------------------------- -----------------------------CREFAAQRLVLLEAGCGVGNCIFPLLEDDLTLF---------VYACDFSPR AVEFVKKH----------------------PLYCPERCCAFQCDLTKDDLRQHVPEGSVDVITLIFVLS----AVHPDKM TLVLQNISRVLKPGGILLFRDYGLHDHAMLRFKAGSKLGENFYVRQDGTRSYFFSKDFLAKLVEEAGLQPVAN------- ----DYVLRETVNKKEGLCVPRVFLQSKFTKPSQSRSL------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Taeniopygia_guttata_(Zebra_finch)METTL6(Chromosome_2:_61884839-61892030) -------------------------------------------------------------------------------- G---------------------------AFQKKGHSAR------VLSPEEAEKL--AKDQVLVSDF--------KQLKLE KEAQKNWDLFYKRNSTNFFKDRHWTTREFQELKA---------------------------------------------- -----------------------------CREFADQKLTILEAGCGVGNCLFPLLEEDMNIF---------AYACDFSPR AVDYVKKN----------------------ALYNTERCKVFQCDLTKDDLLDNIPADSVDVVTLIFVLS----AIHPDKM HLVLRNIYKVLKPGKCVLFRDYGLYDHAMLRFKSGSKLGENFYVRQDGTRSYFFTEEFLSQLFKAEGYEQVVN------- ----EYVQRETVNRKEDLHVPRVFLQSKFQKP------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Danio_rerio_(Zebrafish)METTL2A(Chromosome_3:_19552544-19570044) -----------------------------------------------MAAPAVAADSPVIENMPETAGGATENSAEAQKR PQFG---------------------TRFLTDPRQVFQHNAWDNVEWSAEQEEAALKKVQENS-QPLPA----EKQ-EEFD DRANEYWNDFYTIHENRFFKDRHWLFTEFPELAPQQK--HLRGAEEKESLEHMLNG-----------------EDVSSN- ------HTHDE-------------------FPGASASYRILEVGCGVGNTVFPILKT-NNDP------GLFVYCCDFSST AVDLVKSN----------------------PEYDPSRCHAFVHDMSDESGEYPMPDHSLDVIVLIFVLS----ALHPEKM QKSINRLGRLLKPGGVLLLRDYGRYDMAQLRFKKGRCLSENFYVRGDGTRVYFFTQDELHDLFSSAGLEKLQN------- ----LVDRRLQVNRGKQLTMYRVWVQCKYRKVLAPT-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Homo_sapiens_(Human)METTL2A(Chromosome_17:_60501228-60527454) ---------------------------------------------------------------MAGSYPEGAPAVLADKR QQFG---------------------SRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQ----EKQ-VDYE INAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK-SEVPEC-RNNEDGPGLIM-----EEQHKCS SKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDP------GLFVYCCDFSST AIELVQTN----------------------SEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLS----AIVPDKM QKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Homo_sapiens_(Human)METTL2B(Chromosome_7:_128116783-128142978) ---------------------------------------------------------------MAGSYPEGAPAILADKR QQFG---------------------SRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQ----EKQ-VDYE INAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK-SEVCEC-RNNEDGPGLIM-----EEQHKCS SKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDP------GLFVYCCDFSST AIELVQTN----------------------SEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLS----AVVPDKM QKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Homo_sapiens_(Human)METTL6(Chromosome_3:_15452524-15469025) -------------------------------------------------------------------------------M A---------------------------SLQRKGLQAR------ILTSEEEEKL--KRDQTLVSDF--------KQQKLE QEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRS---------------------------------------------- -----------------------------CREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIF---------AYACDFSPR AIEYVKQN----------------------PLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLS----AVHPDKM HLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVN------- ----EYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Homo_sapiens_(Human)METTL8(Chromosome_2:_172180297-172290596) ----------------------------------------------------MNMIWRNSISCLRLGKVPHRYQSGYHPV APLG---------------------SRILTDPAKVFEHNMWDHMQWSKEEEAAARKKVKENSAVRVLL----EEQ-VKYE REASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGS --SEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSP------ESFLYCCDFASG AVELVKSH----------------------SSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLS----SIHPDRM QGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQN------- ----LVDRRLQVNRKKQVKMH----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Danio_rerio_(Zebrafish)METTL8(Chromosome_9:_3515641-3531474) ------------------------------------------------------MRGLVKLTARAVSFIPCRQCGGGRPP APLG---------------------GRILSNPDDVFKHNMWDHVQWTEEEREKARQKAEENSEEKIPV----EEQ-SKYD REAHKYWDQFYEMHQNKFFRNRNWLFTEFPELLP-------------------PDTGGMLM------AEQEQGLESVNRE KHDYKDTY-----------------------PGHHAAFRILEVGCGAGNSVFPIINTIRGS-------KAFLYCCDFSSR AIELIQKH----------------------PDYDPAVCHAFVRDICDATSPFPFPPESLDIILVVFVLS----AIHPARA QAVVRGLAGLLKQGGMVLFRDYGRYDLSQLRFKKGQCLSENFYSRQDGTCVYFFTKDEVHGLFSAAGLEELQN------- ----LEDRRLQVNRGKKILMHRVWMQSKYRKPEK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Takifugu_rubripes_(Fugu)METTL6b(scaffold_8140:_2753-3864) -------------------------------------------------------------------------------S V---------------------------LGQDTKATNR------VLTQEEMDKL--DGE-VLVSDF--------KQIKLE KEAQKNWDLFYKRNSTNFFKDRHWTTREFEELKA---------------------------------------------- -----------------------------CREFASQQLVLLEAGCGVGNCIFPLLDDELNIF---------VYACDFSPR AVEFVKKN----------------------PLYSPERCCAFQCDLTKDDLRENVPEGSVDVITLIFVLS----AVH-DKM KLVLQNISRVRT------FKN------VIVSFICKAQ------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Tetraodon_nigroviridis_(Tetraodon)METTL8b(Chromosome_2:_13809251-13811901) ---------------------------------------------------------------LCSTITTRFKGTDGRPS APLG---------------------SRILTSPDDVFNHNMWDHIQWTEEDIENARQKAEENSSVQIPL----HEQ-RKFD FQAREFWDKFYTMHQDKFFKDRKWLLFEFPELLPSGATN-------------MPHASGAS-------TDTENQQRHHNSP AHHQKQTSGDPSSCQGADAEKDEDSRR--TFPGQHASFRILEVGCGVGNSLFPIIHSIRET-------NAFLFCCDFSPC AIRLLKAN----------------------PEYDECVCHAFVHDICEETACLPFPPQSLDAILAVFVLS----AIHPDRL QGVVNRLSSYLKHGGIFLFRDYGRYDFSQLRFKKGQCLSENFYTRGDGTCVYFFTKGETHHLFTNAGLEEVQN------- ----LQDRRLQVNRGKKVAMLRVWTQSKYRKP------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gasterosteus_aculeatus_(Stickleback)METTL2A_(groupXI:_6226291-6229551) -------------------------------------------------------------------------------- ----------------------------LTDPRQVFQHNAWDNVEWSEEQEASAKRKVSENN-QPLPQ----EKQ-EEYD SRANEFWNGFYTIHENRFFKDRHWLFTEFPELAPQCSLDNESHLEVSDSDHSQQER-----------------LQREHRS EVPSLSHTDGD-------------------IPGSLATYRILEVGCGVGNTVFPILKT-NNDS------GLFVYCCDFSST AVELVKTN----------------------PEYDPGRCFAFVHDLSDVEADYPVPEGTLDVIVLIFVLS----ALHPDKM QASISRLARLLKPGGVMLLRDYGRYDMAQLRFKKGRCLSENFYVRGDGTRVYFFTQDEVHEMFTEAGLEKMQN------- ----LVDRRLQVNRGKQLTMYRVWIQCKYRKAP-AQPLGSDGQVRGKDPPSSTIA------------------------- -------------------------------------------------------------------