>Homo sapiens SHH
-------------------------------------------MLLLARCLLLVLVSSLLVCSGLACGPGRGFG-KRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADD---QGRLLYSDFLTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPE----ASSGSGPPSGGALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRG-----------GGGGRVALTAPGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS
>Mus musculus SHH
------------------------------------------MLLLLARCFLVILASSLLVCPGLACGPGRGFG-KRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADD---QGRLLYSDFLTFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGP-------------------TPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTD----------------------GGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPLGMAVKSS
>Rattus norvegicus SHH
------------------------------------------MLLLLARCFLVALASSLLVCPGLACGPGRGFG-KRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADD---QGRLLYSDFLTFLDRDEGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSGP-------------------TPGPSPLFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEAAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTD----------------------GGGGGSIPAPQSVAEARGAGPAAGIHWYSQLLYHIGTWLLDSETLHPLGMAVKSS
>Canis familiaris Shh
-----------------------------------------DEMLLLARCMLAVLVCALLMCSGLACGPGRGFG-KRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADD---QGRLLYSDFLTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPLNDSA------------------------------RVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEATGAYAPLTAQGTILINRVLASCYAVIEEHGWAHRAFAPFRLAHALR-------------------------------------------AADAPGA---AGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS
>Gallus gallus SHH
----------------------------------------MDEMLLLTRILLVGFICALLVSSGLTCGPGRGIG-KRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEHGGTKLVKDLSPGDRVLAADA---DGRLLYSDFLTFLDREDSSRKLFYVIETRQPRARLLLTAAHLLFVAPQHNQSEATG----------------STSGQALFASNVKPGQRVYVLGE--GGQQLLPASVHSVSLREEASGAYAPLTAQGTILINRVLASCYAVIEEHSWAHWAFAPFRLAQGLLAALCP-------------------------------------DGAIPTAATTTTGIHWYSRLLYRIGSWVLDGDALHPLGMVAPAS
>Xenopus tropicalis SHH
-------------------------------------------MLVVTRILLLGFICTLVAPPGLACGPGRGIG-KRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSDRFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYFESKAHIHCSVKA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>Tetraodon nigroviridis SHH
-------------------------------------------MLLWTRIVLVGLLCLSLVSSGMGCGPGRGYG-RRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNTDIIFKDEENTGADRLMTQRRVETAAALWECFEHYRDLKNGWNSVKAHGDDGFLIARRCKDKLNSLAISVMNQWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSSTVTLQDGTKKLVKDLQSGDRVLAADG---DGNPTYSDFITFIDRDSATRRLFHVIETDS-GQKITLTAAHLLFVARNGSGGDG---------------------MSAVFASQVRRGQKVMVSDP---ERGRLAPVTVKRIYTQEHVGSYAPVTVQGNVVVDEILASCYAVIEDHDLAHWALAPVRLAHWVSSLLS---------------------------------------SSQPGGGGQRDGVHWYSRLLYQVGTWLLDSQAIHPLGMSVSPS
>Danio rerio SHH
-------------------------------------------MRLLTRVLLVSLLTLSLVVSGLACGPGRGYG-RRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNSLAISVMNHWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSALVSLQDGGQKAVKDLNPGDKVLAADS---AGNLVFSDFIMFTDRDSTTRRVFYVIETQEPVEKITLTAAHLLFVLDNSTEDLHT--------------------MTAAYASSVRAGQKVMVVD----DSGQLKSVIVQRIYTEEQRGSFAPVTAHGTIVVDRILASCYAVIEDQGLAHLAFAPARLYYYVSSFLFPQ-----------------------------------NSSSRSNATLQQEGVHWYSRLLYQMGTWLLDSNMLHPLGMSVNSS
>Danio rerio twhh
----------------------------------------MDVRLHLKQFALLCFISLLLTPCGLACGPGRGYG-KRRH-PKKLTPLAYKQFIPNVAEKTLGASGKYEGKITRNSERFKELIPNYNPDIIFKDEENTNADRLMTKR--------------------------------------CKDKLNSLAISVMNHWPGVKLRVTEGWDEDGHHLEESLHYEGRAVDITTSDRDKSKYGMLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSGTVTLGDGTRKPIKDLKVGDRVLAADE---KGNVLISDFIMFIDHDPTTRRQFIVIETSEPFTKLTLTAAHLVFVG-NSSAASG---------------------ITATFASNVKPGDTVLVWED---TCESLKSVTVKRIYTEEHEGSFAPVTAHGTIIVDQVLASCYAVIENHKWAHWAFAPVRLCHKLMTWLFP--------------------------------------ARESNVNFQEDGIHWYSNMLFHIGSWLLDRDSFHPLGILHLS-
>Takifugu rubripes SHH
-------------------------------------------MLLWTRIVLVGLLCLSLVSSGMGCGPGRGYG-RRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNTDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNSLAISVMNQWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSSTVTLQDGTKKLVKHLRSGDRVLAADD---DGNPTYTDFIMFVDRDSTTRRLYHVIETDS-GQKITLTAAHLLYVARNGTEGDG---------------------MSAVFASQVRRGQKVIVSDP---ERSRLEPVTVERIYTQEHVGSYAPVTVQGNVVVDEILASCYAVIEDHDLAHWALAPVRLAHWVSSLLS---------------------------------------RSQPGGGGQKDGVHWYSRLLYQVGTWLLDGHAIHPLGMSVSPS
>Gasterosteus aculeatus SHH
-------------------------------------------MLLWNRIVLVGLICLSLVSSGMGCGPGRGYG-RRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNTDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNSLAISVMNQWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSSTVTLQDGTKKAVKHLQTGDRVLAGDV---EGNPTYTDFIMFIDQDSTTRRLFHVIETDS-GQKITLTAAHLLFVGRNATAGER---------------------MSAVFASQVRSGQKVFVFDA---ERSRLEPVTVRRIYTREHEGSFAPVTAQGTVVVDQVLASCYAVIEDHDLAHWALAPVRLAHWVSSLLF---------------------------------------RSQRGASAQSDGVHWYSKMLYQVGSWLLDSHSIHPLGMSVYSS
>Oryzias latipes SHH
------------------------------------------KMLLWAKFVLVGLFCLSLVSSGMGCGPGRGYG-RRRH-PKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNTDIIFKDEENTGADRLMTQR--------------------------------------CKDKLNSLAISVMNQWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSSTVTLENGTQRPVKDLQPGDRVLAADY---DGNPVYTDFIMFIDRDSSTSRIFYVIETES-GQKVTLTAAHLLFIAHNSTQAERR--------------------MSAVFASQVRPGQKVFVFG-----RGLLAPVTVKRIYTQRHEGSFAPVTAQGTVVVDQVLASCYAVIEDHSLAHWALAPVRLAHWVSSLLF---------------------------------------GSQPRVSAQSEGVHWYSKILYQLGTWLLDSHSIHPLGMSVSPS
>Homo sapiens DHH
--------------------------------------------MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTER--------------------------------------CKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADA---SGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGD--------------------FAPVFARRLRAGDSVLAP----GGD-ALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTG-------------------------------------------MHWYSRLLYRLAEELLG--------------
>Mus musculus DHH
--------------------------------------------MALPASLLPLCCLALLALSAQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSMPERTLGASGPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTER--------------------------------------CKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADA---AGRVVPTPVLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGD--------------------FAPVFARRLRAGDSVLAP----GGD-ALQPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTG-------------------------------------------MHWYSRLLYRLAEELMG--------------
>Rattus norvegicus DHH
--------------------------------------------MALPASLLPLCCLALLALSVQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSMPERTLGASGPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTER--------------------------------------CKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADA---AGRVVPTPVLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGD--------------------FAPVFARRLRAGDSVLAP----GGD-ALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTG-------------------------------------------MHWYSRLLYRLAEELMG--------------
>Bos taurus DHH
------------------------------------------ASMALPASLVPLCCLALLALPAQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSVPERTLGASGPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTER--------------------------------------CKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADA---AGRVVPTPVLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGD--------------------FAPVFARRLRAGDSVLAP----GGD-ALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTG-------------------------------------------MHWYSRFLYRLAEELLD--------------
>Danio rerio DHH
---------------------------------------MTLAPWLRLARLGLLTVCLYSWLVVDGRGPGPGYGGRHR--QRKLTPMSYKQYVPGVSENNLGASGRAEGRITRSSERFNELVCNYNTDIDFKDEERSNADRFMTKR--------------------------------------CKDCLNKLAIAVMNQWPGVRLRVTEAWDEDGHHPPGSLHYEGRAVDITTSDRDTKKYGLLAQLAVEAGFDWVHYESKYHVHCSVKADHSVAVEKGGCFSASGLVTMADGVQKPMSCLWPGEKVLSVSG---SGEVVFSRVLLFLHLDRESRTSFFIITTE-NEKRIALTPNHLIFAAHNLKLHHHD--------------------YETVFARNVRIGDYILTT----GGDRGIQPSKVVSVSLEERMGVYAPLTEHGNLFVDGVLASNYATFQDHGLAHTVFWPFRVLFVFFNKEMEEDLQRVAVPYICSTNQTILTSVMHSRLSSVFKWQDATRAEMENAFLQQKEVYWYARLLHTLGRIFLDPQRFY---------
>Gasterosteus aculeatus DHH
----------------------------------PQPSPMKQSLWARLAQVGLLAVWTCVWLVQ-GCGPGPGYGIRSR--TRRLTAMHYKQFFPNFSENNLGASGRAEGKITRNSERFNELVCNYNTDIVFKDEENTNADRFMTKR--------------------------------------CKDCLNRLAIAVMNQWPGVHLRVTEAWDEDGHHPPGSLHYEGRAVDITTDDRETEKYGLLAQLAVEAGFDWVHYESKYHIHCSVKADHSVAVEKGGCFPGWARVTVAGGVQKSLSSLAAGDRVMALSG---TGQVVLSQVLLFLHQDHESWSTFLSLETE-DGHRLALTPHHLVFLSSHCRLDSSE--------------------YEAQFASRAKTGDCVLIH----TAEAQVRPSRIISVSEEESVGVYAPLTEAGSVFVEGVLASCYALMDDHRLAHWAFGPVRLLSSFNHLLWEETR----------------------------------------------HVHWYAELLYSLRWTFLDSNSFYP--------
>Oryzias latipes DHH
---------------------------------------MKQFCWARLVQLCLLAAWTCVWLVE-GCGPGPGYGIRSR--PRKLTAMHYKQFFPNFSENNLGASGRAEGKITRDSERFNELVCNYNPDIVFKDEENTDADRLMTKR--------------------------------------CKDCLNRLAIAVMNQWPGVHLRVTEAWDEDGHHPQGSLHYEGRAVDITTDDRETEKYGLLAQLAVEAGFDWVHYESKYHVHCSVKADHSVAVERGGCFPGWARVTLAGGRQKTLSSLAPGDRVMALSD---TGQVVYTRVLSFLHQDQESVSTFLSLETE-EGYTLVLTPHHLVFLAPNCGHDISE--------------------YQARFASRAKTGDCVLIS----TADSQTLPSPIVSVSVAESVGVYAPLTEAGTLFVDRVLASSYALVEDHRLAHWAFGPLRLFYSLKELLWAEAADQTTTGSISLTNIRSHFSTLTIKHNNLTEPFRMKIQEKR-----LSKIHWYARLLYRFAWVLLDSNLFYP--------
>Homo sapiens IHH
--------------------------------------MSPARLRPRLHFC-LVLLLLLVVPAAWGCGPGRVVGSRRRP-PRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGE---DGSPTFSDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAAR--------------------FRATFASHVQPGQYVLVA-----GVPGLQPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFHSLAW----------------------------------------------GSWTPGEGVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS
>Mus musculus IHH
MESPRATQTPESPKLSQPRAHLSAHQAPSPAALPGYPAMSPAWLRPRLRFC-LFLLLLLLVPAARGCGPGRVVGSRRRP-PRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLENGERVALSAVKPGDRVLAMGE---DGTPTFSDVLIFLDREPNRLRAFQVIETQDPPRRLALTPAHLLFIADNHTEPAAH--------------------FRATFASHVQPGQYVLVS-----GVPGLQPARVAAVSTHVALGSYAPLTRHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFPSLAW----------------------------------------------GSWTPSEGVHWYPQMLYRLGRLLLEESTFHPLGMSGAGS
>Rattus norvegicus IHH
LESPRATQTPESPKLCQPRTHPSAHQAPSPVALPGYPAMSPAWLRPRLRFC-LLLLLLLLVPAARGCGPGRVVGSRRRP-PRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVHLETGERVALSAVKPGDRVLAMGE---DGNPTFSDVLIFLDREPNRLRAFQVIETQDPPRRLALTPAHLLFIADNHTEPAAR--------------------FRATFASHVQPGQYVLVA-----GVPGLQPARVAAISTHVALGSYAPLTRHGTLVVEDVVASCFAAVSDHHLAQLAFWPLRLFPSLPW----------------------------------------------GSWTPSEGVHWYPQLLYRLGRLLLEESTFHPLGMSGAGS
>Gallus gallus IHH
--------------------------------------MKPARLLLLLSGC-----ALLLAPAVRCCGPGRVVGSRRRP-PRKLIPLAYKQFSPNVPEKTLGASGRYEGKIARNSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGMLARLAVEAGFDWVYYESKAHIHCSVKSEHLVAAKTGGCFSGRALATLENGARTPLWALRPGQRVLAMDG---AGRPTYSDFLAFLDKEPRALTAFHVIETRQPPRRLALTPTHLLFVADNASAPAAQ--------------------FRPTFASHVQPGHFVLVAV----GSGGLQPAEVVGVRGRTDVGAYAPLTRHGTLVVDDVVASCFALVREQQLAQMAFWPLRLYHSLLG----------------------------------------------GPGVQGDGVHSYSGLLYRLGRMLLPPDSFHPLGAPRAES
>Bos taurus IHH
LEPPGATRTPEPPQRSGLLVHPSAHQASSPAAPRGSPAMSPARLRPRLRFCLLLLLLLLLVPAARGCGPGRVVGSRRRP-PRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQR--------------------------------------CKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGE---DGNPTFSDVLIFLDREPDRLRAFQVIETQDPPRRLALTPAHLLFTANNHTEPAAH--------------------FRATFASQVQPGQYVLVA-----GVPGLQPARVAAVSTHVALGAYAPLTRHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFHSLAW----------------------------------------------GSWTPGEGVHWYPQLLYRLGRLLLEEGSFHSLGVAGAGS
>Danio rerio IHH
-------------------------------------------MRLPVVFGLLVGCALIFAPVNEGCGPGRGHG-KRRP-PKKLTPLNYKQFSPNVAEKTLGASGRIEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMT--------------------------------------QRCKDKLNSLAISVMNMWPGVKLRVTEGWDEDGNHFEDSLHYEGRAVDITTSDRDRNKYGMLARLAVEAGFDWVYYESKAHIHCSVKSEHSVAAKTGGCFPASALVTVEDGSLKTLDSLQPGEKVLASSESDGSGTLVYSEVIAFLDRDPSARKQFFTIETDS-GAKLSLTAAHLLFVSEGNCSG---------------SAAN--AELRSVFASDVLPGQCVVST-QAAGQHGRLS--RVSRIQMQEDRGVFAPLTSHGTVVVNGIVSSCYAAVDQHWLAHWAFGPLRVLYNWGG----------------------------------------------PVGHQVTGIHWYSSLLHWIGTQVLDPAHFHPWSMMDNDR
>Tetraodon nigroviridis IHH
---------------------------------------MRISFLRLTASLCALVLLFLLAPASEGCGPGRGYG-KRRL-PKKLIPLAYKQFSPNVAEKTLGASGRPEGKITRNSERFKELTPNYNTDIIFKDEEDTGADRLMT--------------------------------------QRCKDKLNSLAISVMNMWPGVKLRVTEGWDEDGHHSGDSLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYESKAHIHCSVKSEHSVAAKTGGCFHGDTQVILEGSVTKPMRDLRPGDRVLASSG--GGGPLVYSSVLSFLDRQPNATSVFYTIGTDA-GHRITLTAAHLIYVTDCAWSGTHGEPYLDSVQGGRSSRDRG---LRIVFASEVRPGQCVLTSGGKLGSPATFS--PVTFVHVRRSTGLYAPLTEHGSIVVNGVLASCYAVVDSHHLAHWALAPLRFFYALMG----------------------------------------------PSGSQTDGLHWYPWLLQRLGTTLL---------------
>Takifugu rubripes IHH
------------------------------------------------------VLLFLLAPASEGCGPGRGYG-KRRL-PKKLIPLAYKQFSPNVAEKTLGASGRPEGKITRNSERFKELTPNYNTDIFFKDEEETGADRLMTQKHTHTDLLH---------VFGSGLSKKTPFLPSLCCLQRCKDKLNSLAISVMNMWPGVKLRVTEGWDEDGHHSEDSLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYESKAHIHCSVKSEHSVAAKTGGCFSGDAQVVLEGGVTKPMRDLRPGDRVLSSSATEGLGPFIYSPVLSFLDRRPNVTSVFYTIGTVA-GHSITLTAAHLIYVTDCVWNETYGDLYLDPAQEVGFSRDRG---LRIVFASEVQPGQCVLTSGGKVGSQATFS--PVTFVRAQRSTGLYAPLTEHGSIVVNGVLASCYAAVDSHRLAHWALAPLRLFYTLLG----------------------------------------------PSGSQTDGLHWYPWLLQRLGTMLLDTEHFHPWGV-----
>Gasterosteus aculeatus IHH
---------------------------------------MRIPFHLLT------ASLCATAPASEGCGPGRGYG-KRRP-PKKLIPLAYKQFSPNVAEKTLGASGRPEGKITRNSERFKELTPNYNTDIIFKDEEDTGADRLMT--------------------------------------QRCKDKLNSLAISVMNMWPGVKLRVTEGWDEDGHHSEDSLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYQSKAHIHCSVKSEHSVAAKTGGCFPGDAQVTLSGGVTKRMQDLRPGDHVLASSTTDGHGPLIYSPVSSFLDYQPNVTKTFCRIGTDT-GLIITVTAAHLIFVTDCTGAK---------------SREAG---VRTVFASEVRPGQCVLTSHGKAGSRASLS--VVTFVEEQGGTGLYAPLTQHGSIVVNGVLASCYAAVDNHHLAHWVLTPLRFFYSLMG----------------------------------------------RSEPQSHGLHWYPRLLQRLGKTLLGAGHFHPWGTEQGHR
>Oryzias latipes IHH_A
-------------------------------------------MLLTTLVTCLAGCAMLLSPASEGCGPGRGHG-KRRS-QRKLVPLSYKQFSPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMT--------------------------------------QRCKDKLNSLAISVMNLWPKVRLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYESKAHIHCSVKSANXTFAKKKGGFVLMVTTALRDG-----YGLPAGEKWIFCAAHSET---IFSHLIIILELDLPKTKXFYTLQTEA-GPELSLTAAHLLFVSEGNCSE---------------GTVPGPGALKTVYASDVQPGQCVL---VLGGQSGCLS--RVNRVSVAVKRGVFAPLTQQGTVVVDGVLASCYAAVNQHLLAHWSFSPLRLMHSWTG----------------------------------------------STGGHSEGLHWYAQLLYWLGRKLLSSGHLHPLAVAQDNR
>Oryzias latipes IHH_B
-----------------------------------PPGAMRISLFLLTAS--LCALVLLLAPALEGCGPGRGIG-KRRF-PKKLIPLAYKQFSPNVAEKTLGASGRPEGKITRSSERFKELTPNYNTDIIFKDEEDTGADRLMT--------------------------------------QRCKDKLNSLAISVMNMWPGVKLRVTEGWDEDGHHSEDSLHYEGRAVDITTSDRDRNKYNMLARLAVEAGFDWVYYESKAHVHCSVKSEHSVAAKTGGCFPGDAQVFLEGGGTKQMRHLLPGDRVLSSSTKDGHTSLLYSPVISFLDRQPNIMKTFYIIGTDA-GFNISLTAAHLIFTADCADGGNKTKPQETFFPSIWTDRGRSGAHLRTVFASQVQPGQCVYTSSEESEPHVRIS--VVTFVEEQRSTGLYAPLTQHGSIVVNGVLSSCYAAVDSHELSHWAFAPLRFLYSMLG----------------------------------------------SSQAQSDGVHWYPRLLHRLGELLLDAGHFHPWGI-----
>Branchiostoma floridae HH
---------------------------------------MAGVLARWMVTLVAISALGTHWGPSEACGPGGRFG-RRRH-PRKLTPFVYKQQMPAVSENTFGASGLFNGRITRDSERFHTLKQNFNTDIIFKDEEKTGADRFMTQTPHSQIRVLG-----SVLLGLTAEQVCIYLGVDRNTLQRCKDKLNALAISVMNQWEGVKLRVTEGWDEDGFHTEESLHYEGRAVDITTSDRDRTKYGMLARLAVEAGFDWVYYESKAHIHCSVKAESDTTATQGGCFPAESWVTRDDGNRIRMRDVRPGDKVLSMDS---GGHPVFSEVLTFMDRDSRGPWVYYTIHTDDRNITVTATPSHLVFVTESRDLSSPR---------------------IAKFMSDARPGEFLLTPDS---DGGGFRKVKIVSVTMREEKGAYAPLTVHGTVVVDNVAMSCYALIESQALAHWVFAPFRLYYQLTSSLWDG---------------------------------------PSHDQTLQEGVHWYPSFFYRYGISLVEPTLLHPTATDS---
>Strongylocentrotus purpuratus hh
----------------------------------------MVRADMVKWLTVQITTVLCLIALTQACHPGRSGKTSHRP--RNRTPLQYKQRVPNISEDTFGASGPPEGRINRNDERFNTLSPNNNDDIVFKDKEGTGADRLMTQR--------------------------------------CKDKLNTLAISVMNEWPGIKLRVVEAWDED-QPNVEPLHAEGRAVDITTSDRDKNKYGALARLAVEAGFDWVNYESKAWVHCSVKSESAAAKNSGGCFPGFSQASLENGRTISMLDIRVGDEVAVVND---DGALDYSDVIMIVHRKLNDSTLFYVIETED-KSVVQLTPQHLIYVSETESSFSQS---------------------KAMFASEVRTNQFVYTTGQN--HDRGVRPKRVVSVTTRLGRTAVAPVTRQGSLVIDDVAISSYAVMRDEWIAHASFAPVRWYSYIRHNMLG---------------------------------------IVDTNTGQEQRVHWYTQRLYKLGKYVMSDRLFLGFDV-----