>Branchiostoma_floridae_(Amphioxus)FZD1XP_002605403 ------------------------------------------MKMRVLVGFGWVGLLVLC-------CVLQGGTLVVRAQ QFS----------------------------------------------SSSSLGHHGRCEAITIPLCTDIQ-------- --YNETIMPNLLNHQKQEDAGLEVHQ--FFPLVKVQCSPDLKFFLCAMYAPVCT-VLEEAIPP--CRSLCNSARTGCEAL MNKFGFQWPESLECS----------------------------------KFPVQGTPGKICVGE-------NRTEQIP-- -------TAVPTANNGNSS------------------------------------------------------------- ----AVTENPIRKDYGFYCPRELKVS-------------------PALGYSFLG---------AKDCGAPCDS------- MYFRDDEVEFAQVWIGIWSVLCACSCLFTVLTYLIDPGRFRYPERPIIFLSACYLMVSVAYIVGYALKEKVSCMEEH--- ----------------------------------HRN-FRRILHGTKKEGCTILFMMLYFFSMASSLWWVILTLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTIAILAMGKVDGDVLSGVCFVGISDIDALRGFVLAPLFLYLVIGTLFLLAGFV SLFRIRTIIKQDG-----TKTDKLEKLMIRIGVFSVLYTVPATIVIACYFYEQAFRREWERSWEI-----DNCKD----- -YFIPCPPGP-----------HARPS-----ANPDFTVFMIKYLMALIVGITSGIWIWTGKTVQAWKRFYGQICFRKQ-- --DET----------------------------------------------VV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Caenorhabditis_elegans_(Nematode)FZD1(Chromosome_I:_9965578-9969403) ---------------------------------------------MHRHILILFLFGCLSADQRLSSTSISS--MNGFST TRK--------------------------------------------------------CEHITIPMCKNLD-------- --YNQTVFPNLLGHTTQSEAGPAIAQ--FNPLIKVKCSEDIRLFLCTVYAPVCT-VLEKPIQP--CRELCLSAKNGCESL MKKFGFQWPDQLDCN----------------------------KFPVTD---LCVGKNSSESSNSKK------------- -----SSNDVTFGVSTIANE------------------------------------------------------------ ----------VVLSPKKCPHHMHTTSGSHF------------------SLPLLSGR-------LPECSLTCEADNQV--P MMFDGRVRRILRIWTAAWSVACFVCSLFTLVTFLVDLSRFAYPVRPILYLAFCYLAISTVYMIGVVGEDGFACGTYGST- -------------------------------------PTTLVTQGGENVGCSALAVVHYFFFMSSCAWWLVLCLAWFLAA NLKWGAESIAALSPYFHAMCWGVPAVLSVTVLVTNSVDGDVFTGICSVGNLNPSALVYFFFTPIVVSLALGAVLLVCGIW SMIRIRSYIKLQHA-DVERNISKLEKLMLRIGAFAIMYSLPTAMNAAIMWYQAVNMPAWLEGWLHH-----RCVR----- -LQDRELFGF--------TYPVDDCPMDPKVAAPEIIVFLLKYVSQLVVGITCAIWVVSSKTLSSYHKAYLALSSRSP-- --------------------TVPAHVDQ-----------------------VNMRD------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Gallus_gallus_(Chicken)FZD1(Chromosome_2:_22082221-22084532) ----MAERRGPAGG----------------GSGEVGGGRRAGGDRCPRRPP---ALPLLLLLWAAALPAGGQPAAQPAAL -----------------------------------------------SERGISIPDHGYCQPISIPLCTDIA-------- --YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSAELKFFLCSMYAPVCT-VLEQALPP--CRSLCERARQGCEAL MNKFGFQWPDTLRCE----------------------------------KFPVHGAG-ELCVGQ-------NASERGTPT ------PALRPESWTSNPQ-RG--------------------------GG------------------------------ ----AGGSGPGEARGRFSCPRALKVP-------------------SYLNYRFLG---------EKDCGAPCEPGRLY-GL MYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTAVAVAYIAGFLLEERVVCNERF--- ----------------------------------AEDGSRTVAQGTKREGCTILFMMLYFFGMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGINNVDALRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFREQWERSWVT-----QSCKS----- -YAIPCP----NNH------SSHHPP-----MSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQ-- --GET----------------------------------------------TV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Gallus_gallus_(Chicken)FZD2(Chromosome_Un_random:_42059629-42061134) -------------------------------------------------------------------------------- -----------------------------------------------------VPDHGFCYPISIPLCTDIA-------- --YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSLELKFFLCSMYAPVCT-VLEQAIPP--CRSICERARQGCEAL MNKFGFQWPERLRCE----------------------------------NFPRHGAE-QICVGQ-------NHSEDGG-- ----SSAALLTSAAPPAAHGTPG--------------------------------------------------------- ------APRYATPDRPFHCPRALKVP-------------------GYLNYKFLG---------EKDCAAPCEPSRPD-GH MFFNEDEIRFARVWILVWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLEERVVCNERF--- ----------------------------------QEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNGIDPLRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHGG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFRQHWERSWIS-----QHCKS----- -LAIPCPLHF-------------TPR-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGK------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Gallus_gallus_(Chicken)FZD3(Chromosome_3:_108617989-108664669) --------------------------------------------------------MAVSWMFCCFWLLDVLVGCTRGHS LFS--------------------------------------------------------CEPIILRMCQDLP-------- --YNTTFMPNLLNHYDQQTAALAMEP--FHPMVNLECSRDFRPFLCALYAPVCMEYGRVTLP---CRRLCQRAYSECSKL MEMFGVSWPEDMECT----------------------------------RFPDCDEPYPRLVD----------------- ------LSLGGEPTEEAPMA------------------------------------------------------------ ----------VQRDYGFWCPRELKIDPDL-------------------GYSFLRVR---------DCSPPCP-------N MYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPA- -----------------------------------QYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAA VPKWGSEAIEKKALLFHASAWGIPGTLTIVLLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGII SLNRVRIEIP-----LEKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAYRGVWETTWIQE-----RCRE----- -YHIPCP--------------YQVTQ----MSRPDLILFLMKYLMALVVGIPSVFWVGSKKTCFEWASFFHGRRKKE--- VVNESRQVLQE-PDFAQ---SLLRDPNT-----------------------PIIRKSRGTSTQGTSTHASSTQLAMLDD- -------------QRSKAG---SVHSKVSSYHGSLHRSRDGR----------------YTPCSYRGIEERLPHG------ -------------SMSRL-TDHSRHSSSHRLNEQSRHSSIRDLSSNPLTHIT-HGTSMNRVIEEDGTSA----------- ------- >Gallus_gallus_(Chicken)FZD4(Chromosome_1:_193007130-193011390) ------------------------------------------------MERRGGGGRMLA---LLLAGLLGG--ARGFGD E-E-----------------------------------------------------ERRCDAIRIAMCQNLG-------- --YNVTKMPNLVGHELQADAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGP--CGGMCLSVKRRCEPV LKEFGFAWPDSLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDEE------ -----------VPLHSKT-------------------------------------------------------------- -----------SLQPGEECHSMGSNSD---------------------QYIWVKRN--------LDCVLKCGYD----AG LYS-RSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF---- ---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLV ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWAVFRYSADD--------------- ---------------------------------SNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQK--CSNRLV---- --------------------------------------------------NSGKVKR-EKRAD------GWVKPGKGNET VV------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Gallus_gallus_(Chicken)FZD5(Chromosome_7:_13194523-13195281) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------LYFFGMASSIWWVFLSLTWFLAA GMKWGNEAIASYAQYFHLAAWLIPSAKSITVLALSSVDGDPVAGVCYVGNQSLENLRGFVLAPLVVYLFTGSLFLLAGFV SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTVLYTVPATIVIACYIYEQHNREAWEQAQNCS-------------- -----CPG--------------DPHR-----PKPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRRFTARCCR----- ------PKKPAGA---------------------------AAYGEAS---PALV-GRTVLPSM-----ASYHKQVPLSHV -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Gallus_gallus_(Chicken)FZD6(Chromosome_2:_134798595-134834093) ----------------------------------------------------------MGVLA-FFVPYSFLLTVVRGHS LFT--------------------------------------------------------CEPITISRCSRMP-------- --YNMTFFPNIMGHYDQDTAALQMEP--FLTLMNLHCSPDVHTFLCKAFVPACLEQVHVIHP---CRNLCEKVYSDCKQL IDTFGITWPEELECS----------------------------------RLVNCDETAPATAP----------------- ------VTTNAHGTQKTPGQ------------------------------------------------------------ ----------TRRDYGFWCPRHLHTSNGQ-------------------GYKFLGID---------QCAPPCP-------N MYFKNYELDVAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVSLMYFIGFLLGNRTACNKADDK- -----------------------------------LEIGETVVLGSQNKACTVLFMVLYFF-MAGTIWWVILTITWFLAA GRKWSCEAIAQKAMWFHAVAWGIPGFLTIMLLAMNKVEGDNISGVCFVGLYDVDASLYFVLLPLCLCVFFGLSLLLAGII SLNHVRQVIQ-----HDGRNQEKLKKFMIRIGVFSGLYLVPLVALLGCYVYELVNRKIWETTWVFD-----HCDQ----- -YHIPCP--------------YQAKA----LARPEIFLFLMKYLLTLIVGISPVFWVGSKKTCSEWANFFNRNRKRDP-- -ISESRRVLQESCEFFLRHNSKVKHKKK--------------HYKSSSHRLKVISKSMGTSTGGT-TNHGTSAVAITNHD Y----------LSQETVAEIKTSPETSEKEMEADGTSAQKAEE--------------GENSGNQMLSVSKLTVDQVEKRN KADS--TCDMSSLSESLKRIGEGRVSPRNDLIESPPLQSSSSQIADVSQ----SGSVSLLVYSAADGRKEMDSGNSSNH- ------- >Gallus_gallus_(Chicken)FZD7(Chromosome_7:_12741968-12745019) --------------------------------------MRPAAGGAGAGLRW-LGLAALL------AALLG-TPCAAAHQ D-----------------------------------------------DKAISVPDHGFCQPISIPLCTDIA-------- --YNQTILPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSAELKFFLCSMYAPVCT-VLEQAIPP--CRSLCERARQGCEAL MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDAPPGP G---GAGGRGATAQPTAGY------------------------LPDLLTPPQ---------------------------- --PA--------AGFSFSCPRQLKVP-------------------PYLGYRFLG---------ERDCGAPCEPGRPN-GL MYFKEAEVRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYAAGFLLEERVVCLERF--- ----------------------------------SEDGYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDVLSGVCYVGIYSVDSLRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFRSTWEKTWLL-----QTCKT----- -YAVPCPS--------------HFAP-----MSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSTGSK-- --GET----------------------------------------------AV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Ciona_intestinalis_(Ascidian)FZD3(Scaffold_HT000177.1:_126064-132339) ----------------------------------------------------------MDIKLGIIILCCVISEVSTSNV HPQ--------------------------------------------------------CRPVTLPMCLRNDNERNKGIK WIYNETTFPNFNNDASESEVEISLSL--LHPLLSTSCSRYLELFLCSVFSPACMGG-GVVPP---CRSLCEVVFDDCAEV VEAFGIIWPQRLHCDNFPPQNGGKMVDTGSDTWGKMVVSRSSWLVWGEALLGDGEVCIPLSGDDVIT------------- -----PALSQNNQEIDNVTK------------------------------------------------------------ ----------YPGEYGLRCPAQLTAPPNEP------------------GYTFLGMQ---------GCGAPCP-------N MYMGDDELMLVRYIICVLASLCALVTSFVLFTFAIDTNRFRYPERPIVFYAAAYFVISVIFLVGFALGSDVACKHEIMDE NNI--------------------------------VIQGAVVVEGPRDRACTIVFMILYFFTVNGTIWWLILTVTWLLAA GFKWGSEAIEKHHLYYHGLAWGIPAVQTMVVVTTGKIEGDNIAGVCFVGLYDSDGLRFLLLLPMSFYLLVGMFVLLTGFI CLNRVRKSLH-----DDETNKKKLAKFMLRIGVFSILYILPQLALIAIYAIEDSNRKSWESAWFVR-----NCGR----- -YGVPCPNL-----------PHPVAQLAQGNPLPGVFIFCMKYIMTLIVALPPLFWVASKKTMASWKEAVTKQRCMDDGN PLSVTQTQLLNDSNNGPHARDAVRKQQS----------------KHSDVIFGGLGGFQGSSASIAAAEAMTSSRARARQE LWEDMTSTDSTLSSRSESTLAKVLEYESHKNKGRRVVGRRRHNQGHPLPLTHNPDEGENNREVDDVINKPVPIKMERNNR IDDVISSQSRSLSDVTRPQSSVTSQPGRPDVVKKQLSISRSDATRSVPDIIKTTELSPPLLRNKPEIPRKPKLSLAKPNT SGRVLEV >Ciona_savignyi_(Ascidian)FZD1(reftig_83:_31444-53279) ----------------------------------------------MKAFGRFKEYSTFA------FMLLML-------- -----------------------------------------------GESESQNVHNGKCELITLSICKGIR-------- --YNETIFPNVLGHQDQAEAGLQINQ--FYPLVKVGCSKTLQSFLCSVYTPMCS-IYQQAFPP--CRHMCEEAR-ACEGI MKQFRFSWPRDLECS----------------------------------RFPIKTED-SLCFGT-------DISPSE--- -----------EIPAFDTG------------------------------------------------------------- --------RLCLSQAGFTCPAHMLVPST-----------------NDLNYEFMD---------AEGCGVPCDAKK----L MYWTESEKQFANLWIGCWSFICVISTLFTVLTYLIDMPRFMYPERPIIFLSGCYLIVAIAYIAGFFLRDTVSCRQFHTSI CPVD----------------------------TPLSSCPKVVTQGAREAGCTVLFMMVYFFSMASSIWWVVLTITWFLAA GLKWGNEAIEAKSPYFHGAAWSIPAIQTIVVLISSKIEGDLLSGICFVGVHNSKHLLWFLLVPLSIYLFVGTCFLVAGFV AMFNIRNVVKHSGGT---GKVEKLERLMVRIGVFSVLYTVPATVMIACYFYEQMNRDSWQKGWFA-----QNCRK----- -MSVPCPCEY-----------AKHKG-----NKPDFIVFIIKYFVMLIVGITSGFWIWSSKTVESWSNFKEQLCCFRS-- --SSQGGAKYQRGA-----------------------------------NNTVQQSGTLPLSGDVMRPLYPISKIDP--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Xenopus_tropicalis_(Frog)FZD2(Scaffold_GL173432.1:_297317-300337) -------------------------------------------FSASAMQGVTRSSNLIV------CHLFALC--LLSFA QLH--------------------------------------------GEKGISVPEHGFCQPISIPLCTDIA-------- --YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSSELRFFLCSMYAPVCT-VLEQAIPP--CRSICERARHGCEAL MNKFGFQWPERLRCE----------------------------------NFPRHGAE-QICVGQ-------NHSEDG--- -----GPTLLTTSPP--HHGTPG--------------------------------------------------------- ------PPIYATLDHPFHCPRVLKVP-------------------SYLNYRFLG---------EKDCAAPCEPSKND-GF MFFSQDEIRFARVWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLGDKVVCNENF--- ----------------------------------SEDGYKTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPLRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVS-----QNCKS----- -LAIPCPLQY-------------TPR-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNNKH-- --GET----------------------------------------------TV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Xenopus_tropicalis_(Frog)FZD4(Scaffold_GL172855.1:_675510-682426) ---------------------------------------------------MGVRALALC----LPLLGCLVGHIAGFGD E-E-----------------------------------------------------ERRCDPIRISMCQNLG-------- --YNVTKMPNLVGHELQADAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGP--CGGMCLSVKRRCEPV LKEFGFAWPESLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDDE------ -----------VPVHSKT-------------------------------------------------------------- -----------PVLPGEDCNSFGPNSD---------------------QYTWVKRS--------MNCVLKCGYD----SG LYS-RLSKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFCYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF---- ---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNIDALTGFVVAPLFTYLVIGTLFIAAGLV ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWNVFRYTADD--------------- ---------------------------------SNMAVEMLNIFMSLLVGITSGMWIWSAKTLHTWQK--CTNRLV---- --------------------------------------------------NSGKVKR-KKRVD------GWVKPGKGNET VV------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Xenopus_tropicalis_(Frog)FZD6(Scaffold_GL172639.1:_1438799-1461513) ----------------------------------------------------------MAARLGKVLLVTLLLPLVQSHS LFT--------------------------------------------------------CEPITVPRCTGMN-------- --YNMTFFPNLLEHYDQDIAALRMEP--FLPLLNLHCSPEVHTFLCRAFVPECTEPKHITMP---CRSLCERVYSDCKNL IETFGITWPAELECD----------------------------------RMRDCNNSQSKGGG----------------- ------GPDDPHDALRHPEQ------------------------------------------------------------ ----------VHRDFKFWCPQHLKTSQGS-------------------GFKFLGVD---------RCAPPCP-------N MYFKKVDMDFAKYFIGIISIICLCVTLFTVLTFLIDVQRFRYPERPIIFYSVCYSMVSLMYVIGFLMGNSIVCNEREEN- -----------------------------------FASGDTVVLGSQHKACTIIFMLLYFCTMAGTIWWVMLTITWFLAA GRKWSCEAIEQKSLWFHGVAWGIPGILTIILLAMNKVEGDNISGVCFVGLYDQEVSIYFVLLPLCLCVFIGLSLLLAGII SLNNVRQVIQ-----HDERNQQKLKKFMIRIGVFSGTYLVPLVILLGCYVYEQVYRSSWEMTWVSD-----NCQD----- -YHIPCP--------------FQLKN----PARPDLGLFITKYIMTLIVGISAIFWVGSKKTCSEWVNFFNRSRKQDP-- -ISESRRVLQESCEFFLKHNAKVKHKKKK-------------HSKSGSHKLKVISKSMGTSTSGK-INHGMTAVTNTSHD F----------LGQEASGDVRSTLDFSRTEDPEGASCIHKSRDD-I----------TGEVTTQTLLDGTEAPVEHTDCNN K------------PGSKR--GNGLPGSIHTILHESLHEVAENRVN--------VESASLDPDQTEDLSKVPGHTSPHDND ------- >Xenopus_tropicalis_(Frog)FZD7(Scaffold_GL172844.1:_1732448-1736539) ----------------------------------------CRAPRIITCCRPGPGMFATVS-----LLFCLLLQPSPSAQ QY--------------------------------------------HGEKGISVPDHGFCQPISIPLCTDIA-------- --YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLEQAIPP--CRSLCERARQGCEAL MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDNS--- -------PSGPTARPTPY-------------------------LPDSITFHP---------------------------- --HP---------NRDFTCPRQLKVP-------------------PYLGYRFLG---------EKDCGAPCEPGKAN-GL MYFKEEEVRFARLWVGIWAILCGISTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYTAGFLLEERGVCVERF--- ----------------------------------SEDSYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVMYTVPATIVLACYFYEQAFRDTWEKTWLV-----QTCKG----- -FAVPCPNY-------------NFAP-----MSPDFTVFMIKYLMTMIVGITSSFWIWSGKTLQSWRRFYHRLSNGGK-- --GET----------------------------------------------AV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Takifugu_rubripes(Fugu)FZD2(scaffold_15:_1304591-1306404) -----------------------------------------LEPKRGEKKQSCLQLGKTW------FVAFLLP--LLVTA QYH--------------------------------------------GDNG-IVPDHGFCQQISIPLCTDIA-------- --YNQTIMPNLVGHYNQEDAGLEVHQ--FYPLVKVQCSPELKFFLCSMYAPVCT-VLEKAIPP--CRSICERAKQGCEAL MNKFGFQWPEPLRCE----------------------------------NFPVQGDE-QICVGQ-------NDSTAA--- ------------TVPPILP-GPGTS------------------------------------------------------- -----DLPFPG--NGPFRCPPALKVP-------------------PHLNYKFLD---------EKDCAAPCEPSRRG-GS MFFTDKEIHFSRVWILVWSVLCCASTLFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSIAYIAGYFLGDAVVCNEGF--- ----------------------------------TPENYKTLVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMGQIEGDVLSGVCFVSLSNLDPLRGFVLAPLFIYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFRAHWERSWFS-----HNCRA----- -FDI-CPTQT-------------GPR-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWHKFYTRLTYGKH-- --GET----------------------------------------------TV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Takifugu_rubripes(Fugu)FZD3(scaffold_28:_334328-347495) ----------------------------------------GCTKGCPSVCFSLLLIPISMLFFLGTPALCIHLETTESHS EFS--------------------------------------------------------CEPIRLRMCQDLP-------- --YNTTFMPNLLHHYDQQTAALAMEP--FHPMVNLECSPDLRMFLCALYTPVCVVYGQVSMP---CRSLCQRAKDECHKL MEIFGVSWPDDMEC-----------------------------------RFPDCDEPYPRPED----------------- ------LLTGSDPTNQSSLT------------------------------------------------------------ ----------VQRDYGFWCPRELKVDTDL-------------------GYTFMGKK---------DCSAPCP-------S MFFSRQELTFIRYFIGVTSLICLSATLFTFLTFLIDVTRFRYPERPIIFYAACYVMVSLVFFLGFLLEDRVACNAASPA- -----------------------------------HFRAATITQGSHNKVCTLFFMVLYFFAMAGSVWWVILTITWFLAA VPKWGSEAIEKKALLFHAVAWGLPGALTVALLALNKIEGDGISGVCFIGLYDIDALRWFVLAPLGLNVTVGVSLLFVGIV ALNKVRMEIP-----LEKENQTKLVKFMIRMGVFSALYVVPLLVVIGCYLYEHTYRSIWETTWMEE-----NCRH----- -YHIPCP--------------YKVKQ----ISHPAAVLFLMKYLMMLVVGIPSVFWVGSKKTCFEWANFLQGRRRKDS-- GVNESRQVLQEQPDFAQ---SLLREPNT-----------------------PVIRKSRGTSTQGTSTHASSTNLAALDGL DDPVQTHQRHAASTRNKAS---SVHSK-ASYHGSLRRTREDRYSS------------KSDTVVYRGAGECSFHG------ -------------SLSRLNHPLSTHSSLHQLDGHSRHNSQQDVTEVPPALIR-HGTTA---------------------- ------- >Takifugu_rubripes(Fugu)FZD4(scaffold_172:_247438-252485) ---------------------------------------------MERRRWGESSLLLLLS-----GLLAALCAVKAFGE ELE-----------------------------------------------------EMTCDPIRISMCQGLG-------- --YNVTKMPNLVGNVLQSDAELQLTT--FTPLIQYGCSSQLKFFLCSVYVPMCTVKIPIPIGP--CSSMCLSVKKKCFPV LQEFGFIWPEELNCS----------------------------------LFPPQNDHNHMCMEGP-----GDED------ -----------LPYPPLW-------------------------------------------------------------- -----------NPHHQQECHALGSGPD---------------------QYIWLKQT--------ESCTLQCGYD----SG LYR-RGTKVFTDAWMAVWAVLCFLSTTLTVLTFVLDSQRFSYPERPIIFLSMCCNLYSVAYLVRWTLGREHVSCDL---- ---------------------------------EATAVPVLVQEGLKSTGCAIVFLLLYFFGMASSLWWVILTLTWFLAA GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADDLTGLCYVGNQQQEALIGFVVAPLATYLLLGTLFICAGLV ALFRIRSNLQKDG-----AKTDKLERLMVKIGVFSVLYTVPASTVIGCYIYQLAHWGEFNTIPQD--------------- ---------------------------------SYVASEMLRIFMSLLVGITSGMWIWSAKTLHTWQR--CSTRLV---- --------------------------------------------------RDSRASRSGQRAPC----TGWIKPGKGNET VV------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Takifugu_rubripes(Fugu)FZD5(scaffold_31:_1191230-1194595) ----------------------------EKKPTDDYIQYELYVKMIHCVAST-----------TAVLLLLV--PGLTFGA SKDLV------------------------------------------------------CEPITVPMCKDIG-------- --YNLTYMPNQFNHDTQEEVGLEVHQ--FWPLVRIRCSPDLLFFLCSMYTPICLPDYRKPLPP--CRSVCERAKQGCSPL MSQYGFEWPERMSCE----------------------------------KLPQLG-D-EVLCMD------QNNTE----- ----STTLAST--FPKPTPK--------------------------VQTRTLSP-------------------------- --------HQCDRECRCRAPLVPIKRE------------------SLTSYHHTHAG------PVPNCAQPCHQP------ -FFSADERAFTSLWIGLWSLLCFISTLTTVATFLIDMERFQYPERPIIFLAGCYLFVSLGYIIRLVAGHEQVACGSSSS- ---------------------------------VHEDQLYLLYDTTGPALCTLVFLLVYFFGMASSIWWVVLSFTWFLAA GLKWGSEAIAGYAQYFHLAAWLIPSLKTIIILAMSSVDADPVAGICYVGNQSLESLRGFVLAPLVVYLFTGSFFLLAGFI SLFRIRSIIKQ-----GGTKTDKLERLMIRIGLFTVLYTVPATVVVACLVYEQHYRPGWEETLACS-------------- -----CLT-E-----------QQLLG-----MGPDYAIFMLKYFMCLVVGITSGVWIWSGKTLESWRRFVAHCCP----- --CWLQT-ATAPP---------------------------SMYSEAS---TALT-GHTGTGLT-----AGFYHKSVSSHI -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Takifugu_rubripes(Fugu)FZD6(scaffold_58:_8671-12922) --------------------------------------------------------MLMPGPL-WTCLALMWLGSSSAHS LFT--------------------------------------------------------CEPIKVHRCLGMS-------- --YNMTFFPNMMDHFDQDIAATHMKP--FMPLVNLRCSPDVHRFLCQAFFPACIEN-TVYRP---CREECNTVMSECKAN IEVFGISWPPELQCD----------------------------------NFFRLDPCFLIGHE----------------- ------TSTET--TPVTSS------------------------------------------------------------- ----------TKRDLGFWCPLQLKTKPGL-------------------GSSFLGTQ---------DCAPPCS-------N MYFKPHDIEFAKSFIGVCSIICLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVSLMYFIGFLLGNNAACTKATHP- -----------------------------------ASV-DTVVLGSQSKGCTLLFMLLYFFSIAGLVWWVILTITWFLAA GPKWSCEAIEKKAVWFHSAAWGIPGSLTVMLLALNKVEGDNISGVCFVGLYNLDALRYFVLAPLGVGVIVGLFLILAGIV SLNNVRQVIQ-----HDERNQEKLKKFMIRIGVFSCLYLVPLVTLLACYTYEQSHRSAWERTWIAD-----RCQE----- -YSIPCP--------------FEAAE----SDRPDLSLFLVKYLMTLVVGISAVFWVSSKKTCSEWAYFFNRTRKKDP-- -ISESRRVLQESCEFFLKHNSRVQHKKK--------------HYSPSSHKLKVISKSMGTSTGAMPSNASATPTL-TNHG A----------STLSNRDAHPQCSLSEASVRSSRRGVRDREREV--------------GERQSKGGSSSKI--------- -------------------------------------------------------------------------------- ------- >Gorilla_gorilla_(Gorilla)FZD1(Chromosome_7:_88490025-88493836) ------------------------------------------GRRRPPVDPRRLARQLLLLLWLLETPLLLGVRAQAAGQ GPGQGPGPGQQPPPPP---------------------QQQQSGQQYNGERGISIPDHGYCQPISIPLCTDIA-------- --YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSAELKFFLCSMYAPVCT-VLEQALPP--CRSLCERARQGCEAL MNKFGFQWPDTLKCE----------------------------------KFPVHGAG-ELCVGQ-------NTSDKGTPT ------PSLLPEFWTSNPQHGG----------------------GGHRGG------------------------------ ---FPGGAGASER-GKFSCPRALKVP-------------------SYLNYHFLG---------EKDCGAPCEPTKVY-GL MYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKF--- ----------------------------------AEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVA-----QSCKS----- -YAIPCPHLQAGGG------APPHPP-----MSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQ-- --GET----------------------------------------------TV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Gorilla_gorilla_(Gorilla)FZD3(Chromosome_8:_28477094-28557203) --------------------------------------------------------MAMTWIVFSFWPLTVFMGHIGGHS LFS--------------------------------------------------------CEPITLRMCQDLP-------- --YNTTFMPNLLNHYDQQTAALAMEP--FHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLP---CRRLCQRAYSECSKL MEMFGVPWPEDMECS----------------------------------RFPDCDEPYPRLVD----------------- ------LNLAGEPTEGAPVA------------------------------------------------------------ ----------VQRDYGFWCPRELKIDPDL-------------------GYSFLHVR---------DCSPPCP-------N MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPA- -----------------------------------QYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAA VPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGII SLNRVRIEIP-----LEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQE-----RCRE----- -YHIPCP--------------YQVTQ----MSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKE--- IVNESRQVLQE-PDFAQ---SLLRDPNT-----------------------PIIRKSRGTSTQGTSTHASSTQLAMVDD- -------------QRSKAG---SIHSKVSSYHGSLHRSRDGR----------------YTPCSYRGMEERLPHG------ -------------SMSRL-TDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHIT-HGTSMNRVIEEDGTSA----------- ------- >Gorilla_gorilla_(Gorilla)FZD4(Chromosome_11:_84242635-84257192) -----------------------------------------KGGGPRSTESPGLISFRIP--LWNFISYRLKATIGGFGD E-E-----------------------------------------------------ERRCDPIRISMCQNLG-------- --YNVTKMPNLVGHELQTDAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGP--CGGMCLSVKRRCEPV LKEFGFAWPESLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDEE------ -----------VPLPHKT-------------------------------------------------------------- -----------PIQPGEECHSVGINSD---------------------QYIWVKRS--------LNCVLKCGYD----AG LYS-RSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF---- ---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLV ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADD--------------- ---------------------------------SNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQK--CSNRLV---- --------------------------------------------------NSGKVKR-EKRGN------GWVKPGKGSET VV------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Gorilla_gorilla_(Gorilla)FZD5(Chromosome_2b:_96411333-96418144) ------------------------------------------MARPDPSAPP-----------SLLLLLLAQLVGRAAAA SKAPV------------------------------------------------------CQEITVPMCRGIG-------- --YNLTHMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPP--CRSVCERAKAGCSPL MRQYGFAWPERMSCD----------------------------------RLPVLGRDAEVLCMD------YNRSE----- ----ATTAPPR-PFPAKPTLPGP--------------------PGAPASGGECP-------------------------- --------AGGPFVCKCREPFVPILKE------------------SHPLYNKVRTG------QVPNCAVPCYQP------ -SFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVAC------ ----------------------------------SREHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAA GMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFV SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCA-------------- -----CPGHD-----------AGQPR-----AKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPR-- --RGHKSGGAMAA---------------------------GDYPEAS---AALT-GRTGPPGP----SATYHKQVSLSHV -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Gorilla_gorilla_(Gorilla)FZD6(Chromosome_8:_102551091-102584379) ----------------------------------------------------------MEMFT-FLLTCIFLP-LVRGHS LFT--------------------------------------------------------CEPITVPRCMKMA-------- --YNMTFFPNLMGHYDQSIAAVEMEH--FLPLANLECSPNIETFLCKAFVPTCTEQIHVVPP---CRKLCEKVYSDCKKL IDTFGIRWPEELECD----------------------------------RLQYCDETVPVTFD----------------- ------PHTEFLGPQKKTEQ------------------------------------------------------------ ----------VQRDIGFWCPRHLKTSGGQ-------------------GYKFLGID---------QCAPPCP-------N MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEK- -----------------------------------LELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAA GRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGII SLNHVRQVIQ-----HDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSD-----HCRQ----- -YHIPCP--------------YQAKA----KARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDP-- -ISESRRVLQESCEFFLKHNSKVKHKKK--------------HYKPSSHKLKVISKSMGTSTGAT-ANHGTSAVAITSHD Y----------LGQETLTEIQTSPETSMREVKADGASTPRLRKQ------------DCGEPASPAASISRLSGEQVDRKG Q--------AGCVSESAR--SEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT- ------- >Gorilla_gorilla_(Gorilla)FZD7(Chromosome_2b:_90515948-90519803) ----------------------------------------MRDPGAAAPLSS-LGLCALV------LALLGALSAGAGAQ PY--------------------------------------------HGEKGISVPDHGFCQPISIPLCTDIA-------- --YNQTILPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLDQAIPP--CRSLCERARQGCEAL MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDGS--- ----GGPGGGPTAYPTAPY------------------------LPDLPFTAL---------------------------- --PPGASDGRGRPGFPFSCPRQLKVP-------------------PYLGYRFLG---------ERDCGAPCEPGRAN-GL MYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERF--- ----------------------------------SDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLL-----QTCKS----- -YAVPCPPG-------------HFPP-----MSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSK-- --GET----------------------------------------------AV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Apis_mellifera_(Honey_bee)FZD1_XP_623523 -----------------------------------------------------------------MIPRYAIYVFSVAVF SVN-------------------------------------------ALHTKDPLAHHGRCEPITINLCMNIP-------- --YNETIMPNLMNHQKQEDAGQEVHQ--FAPLVKMKCSPDLRFFLCTVYAPVCT-IIDRAIPP--CRSLCESARAGCERL MNSFGFAWPDNLDCS----------------------------------KLPENGGP-ELCVGH-------NETTPP--- -----EPSPPVYTPPRMPVAEFQPS------------------WTGGPKTYG---------------------------- -----SGFMLGARDFGFVCPMQFKVP-------------------HELGYSLKVGDK-----VELNCGAPCDG------- MFFTERERRFSRIWVGTWASVCAASCFFTFLTFLIDTDRFRYPERPIIFLSVCYLMVALAYVIGWAAGNSIACREPFPPP L-------------------------------DMRIQMASTITQGTKHELCTVLFMVLYFFGMASSIWWVILTLTWFLAA GLKWGHEAIEANSQYFHLAAWAAPAIKTVTILAMGKVEGDILSGVCYVGLWNVEALRGFVLAPLCVYLILGTAFLLAGFV SLFRIRTVMKHDG-----TKTDKLEKLMIRIGIFSVLYIVPALIVIACLFYEQAYFDQWMLTWNM-----EMCSRPGPQS LYSMPCPVGER----------TRDVG-----RRPEFEVFMIKYLMAMIVGITSSFWVWSSKTLTSWRQFFN-HIQGRR-- --AEA----------------------------------------------YV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Homo_sapiens_(Human)FZD1(Chromosome_7:_90893783-90898123) MAEEEAPKKSRAAGGG---ASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQ GPGQGPGPGQQPPPPP---------------------QQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIA-------- --YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSAELKFFLCSMYAPVCT-VLEQALPP--CRSLCERARQGCEAL MNKFGFQWPDTLKCE----------------------------------KFPVHGAG-ELCVGQ-------NTSDKGTPT ------PSLLPEFWTSNPQHGG----------------------GGHRGG------------------------------ ---FPGGAGASER-GKFSCPRALKVP-------------------SYLNYHFLG---------EKDCGAPCEPTKVY-GL MYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKF--- ----------------------------------AEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVA-----QSCKS----- -YAIPCPHLQAGGG------APPHPP-----MSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQ-- --GET----------------------------------------------TV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Homo_sapiens_(Human)FZD2(Chromosome_17:_42634925-42636907) -------------------------------------------------MRPRSALPRLL------LPLLLLP--AAGPA QFH--------------------------------------------GEKGISIPDHGFCQPISIPLCTDIA-------- --YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLEQAIPP--CRSICERARQGCEAL MNKFGFQWPERLRCE----------------------------------HFPRHGAE-QICVGQ-------NHSEDG--- -----APALLTTAPPPGLQPGAGGT------------------PGGPGGGGA---------------------------- ------PPRYATLEHPFHCPRVLKVP-------------------SYLSYKFLG---------ERDCAAPCEPARPD-GS MFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERF--- ----------------------------------SEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVS-----QHCKS----- -LAIPCPAHY-------------TPR-----MSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRH-- --GET----------------------------------------------TV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Homo_sapiens_(Human)FZD3(Chromosome_8:_28351773-28431775) --------------------------------------------------------MAMTWIVFSLWPLTVFMGHIGGHS LFS--------------------------------------------------------CEPITLRMCQDLP-------- --YNTTFMPNLLNHYDQQTAALAMEP--FHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLP---CRRLCQRAYSECSKL MEMFGVPWPEDMECS----------------------------------RFPDCDEPYPRLVD----------------- ------LNLAGEPTEGAPVA------------------------------------------------------------ ----------VQRDYGFWCPRELKIDPDL-------------------GYSFLHVR---------DCSPPCP-------N MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPA- -----------------------------------QYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAA VPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGII SLNRVRIEIP-----LEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQE-----RCRE----- -YHIPCP--------------YQVTQ----MSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKE--- IVNESRQVLQE-PDFAQ---SLLRDPNT-----------------------PIIRKSRGTSTQGTSTHASSTQLAMVDD- -------------QRSKAG---SIHSKVSSYHGSLHRSRDGR----------------YTPCSYRGMEERLPHG------ -------------SMSRL-TDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHIT-HGTSMNRVIEEDGTSA----------- ------- >Homo_sapiens_(Human)FZD4(Chromosome_11:_86656721-86666433) --------------------------------------MAWRGAGPSVPGAPGGVGLSLG---LLLQLLLLLGPARGFGD E-E-----------------------------------------------------ERRCDPIRISMCQNLG-------- --YNVTKMPNLVGHELQTDAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGP--CGGMCLSVKRRCEPV LKEFGFAWPESLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDEE------ -----------VPLPHKT-------------------------------------------------------------- -----------PIQPGEECHSVGTNSD---------------------QYIWVKRS--------LNCVLKCGYD----AG LYS-RSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF---- ---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLV ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADD--------------- ---------------------------------SNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQK--CSNRLV---- --------------------------------------------------NSGKVKR-EKRGN------GWVKPGKGSET VV------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Homo_sapiens_(Human)FZD5(Chromosome_2:_208627310-208634287) ------------------------------------------MARPDPSAPP-----------SLLLLLLAQLVGRAAAA SKAPV------------------------------------------------------CQEITVPMCRGIG-------- --YNLTHMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPP--CRSVCERAKAGCSPL MRQYGFAWPERMSCD----------------------------------RLPVLGRDAEVLCMD------YNRSE----- ----ATTAPPR-PFPAKPTLPGP--------------------PGAPASGGECP-------------------------- --------AGGPFVCKCREPFVPILKE------------------SHPLYNKVRTG------QVPNCAVPCYQP------ -SFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVAC------ ----------------------------------SREHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAA GMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFV SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCA-------------- -----CPGHD-----------TGQPR-----AKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPR-- --RGHKSGGAMAA---------------------------GDYPEAS---AALT-GRTGPPGP----AATYHKQVSLSHV -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Homo_sapiens_(Human)FZD6(Chromosome_8:_104310661-104345045) ----------------------------------------------------------MEMFT-FLLTCIFLP-LLRGHS LFT--------------------------------------------------------CEPITVPRCMKMA-------- --YNMTFFPNLMGHYDQSIAAVEMEH--FLPLANLECSPNIETFLCKAFVPTCIEQIHVVPP---CRKLCEKVYSDCKKL IDTFGIRWPEELECD----------------------------------RLQYCDETVPVTFD----------------- ------PHTEFLGPQKKTEQ------------------------------------------------------------ ----------VQRDIGFWCPRHLKTSGGQ-------------------GYKFLGID---------QCAPPCP-------N MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEK- -----------------------------------LELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAA GRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGII SLNHVRQVIQ-----HDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSD-----HCRQ----- -YHIPCP--------------YQAKA----KARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDP-- -ISESRRVLQESCEFFLKHNSKVKHKKK--------------HYKPSSHKLKVISKSMGTSTGAT-ANHGTSAVAITSHD Y----------LGQETLTEIQTSPETSMREVKADGASTPRLREQ------------DCGEPASPAASISRLSGEQVDGKG Q--------AGSVSESAR--SEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT- ------- >Homo_sapiens_(Human)FZD7(Chromosome_2:_202899310-202903160) ----------------------------------------MRDPGAAAPLSS-LGLCALV------LALLGALSAGAGAQ PY--------------------------------------------HGEKGISVPDHGFCQPISIPLCTDIA-------- --YNQTILPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLDQAIPP--CRSLCERARQGCEAL MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDGS--- ----GGPGGGPTAYPTAPY------------------------LPDLPFTAL---------------------------- --PPGASDGRGRPAFPFSCPRQLKVP-------------------PYLGYRFLG---------ERDCGAPCEPGRAN-GL MYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERF--- ----------------------------------SDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLL-----QTCKS----- -YAVPCPPG-------------HFPP-----MSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSK-- --GET----------------------------------------------AV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Homo_sapiens_(Human)FZD8(Chromosome_10:_35927177-35930362) ----------------------------------------MEWGYLLEVTSL-----------LAALALLQRSSGAAAAS AKELA------------------------------------------------------CQEITVPLCKGIG-------- --YNYTYMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPP--CRSVCERAKAGCAPL MRQYGFAWPDRMRCD----------------------------------RLPEQG-NPDTLCMD------YNRTD----- ----LTTAAPSPPRRLPPPPP--------------GEQPPSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGK ARPPGGGAAPCEPGCQCRAPMVSVSSE------------------RHPLYNRVKTG------QIANCALPCHNP------ -FFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPG AGGAGGAGG-AAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAA GMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFV SLFRIRSVIKQQD---GPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCP-------------- -----CLRDL-----------QPDQA-----RRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSLCTRCCWASK-- --GAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGGGGGSLYSDVS---TGLT-WRSGTASS-----VSYPKQMPLSQV -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Homo_sapiens_(Human)FZD9(Chromosome_7:_72848109-72850450) -----------------------------------------------MAVAP-LRGALLLWQLLAAGGAALEIGRFDPER GRG-----------------------------------------------------AAPCQAVEIPMCRGIG-------- --YNLTRMPNLLGHTSQGEAAAELAE--FAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPA--CRPMCEQARLRCAPI MEQFNFGWPDSLDCA----------------------------------RLPTRNDPHALCMEAP-----ENATAGPA-- EPHKGLGMLPVAPRPARPP------------------------------------------------------------- ----------GDLGPGAGGSGTCENPE---------------------KFQYVEKS--------RSCAPRCGPG----VE VFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACD----- ---------------------------------QEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAA GKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFV ALFHIRKIMKTGG-----TNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGG---- --RRDCSLPGG--------------------SVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQS-LCYRKIA-A-- --------------------------------------GRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPT HL------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Homo_sapiens_(Human)FZD10(Chromosome_12:_130647004-130650284) -------------------------------------------------MQRPGPRLWLVLQVMG---SCAAISSMDMER PG------------------------------------------------------DGKCQPIEIPMCKDIG-------- --YNMTRMPNLMGHENQREAAIQLHE--FAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPA--CRVMCEQARLKCSPI MEQFNFKWPDSLDCR----------------------------------KLPNKNDPNYLCMEAP-----NNGS-----D EPTRGSGLFPPLFRPQRPHSAQE--------------------------------------------------------- ----------HPLKDGGPGRGGCDNPG---------------------KFHHVEKS--------ASCAPLCTPG----VD VYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACD----- ---------------------------------RDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAA GKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFV ALFHIRRVMKTGG-----ENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMN-NQTK---- --TLDCLMAA---------------------SIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQ-VCSRRLK---- --------------------------------------KKSRRKPASVITSGGIYKKAQHPQK---THHGKYEIPAQSPT CV------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Hydra_magnipapillata(Hydra)FZD1ACC54556 ---------------------------------------------MRRNLYLHILKSVIIHLLCLNLIFCEPRGIRERYE TRK--------------------------------------------------------CEKLSITMCEKVG-------- --YNLTFMPNKHGHVNQIDAGQLIRQ--FAPLVAINCSPLLAHFVCSLYAPMCDPVYNKDIVP--CQSLCENIRNSCEKF MKQNGYTWPDNLQCS----------------------------QFPTREKDPICMKPDFDFPEPS--------------- -----IPTHLNLPDENKKTS------------------------------------------------------------ ----------LIQTKDVFKIRDFSGCGCLC------------------KYPFVSVNSSSNTDLFPPCVLPCG-------Q YFFSNTQNIFMKFWLSLWSILSLITTAVTLLTFLIDRTKFKFVEQPIILISFCYFIVSFGYIIRLIY--GFKAIACNDH- -------------------------------------TGFLHYASTGPASCTAVFILTYFFTNVSWIWWVVLSINWFLSS GLKWTNGTISSYSQYFHFVAWLIPTIQTMAILAMSAIDGDPVSGLCTVGNHDSNTLTIFVIGPLLIYTMLSLSFFIAGVV AKLRIEQTIR-----NEAKNNLKSGRFLSRVGMFTLILFVPAVSLLGCYFYEHSYKEIWEK------------------- ---------------------STNCDCMPIKKQPIFYIFLFKYLMSLVIGIAIGLGTLNSDALGAWRRFFKRHCKITK-- --------------------SLAQEKNG-----------------------QLIPNNSKKGVAI---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Anolis_carolinensis_(Lizard)FZD2(Chromosome_6:_63838547-63840229) -------------------------------------------MRLHHDASLAR-SPLVF------FFLLLLL--CSCWA QFH--------------------------------------------GEKGISIPDHGFCQPISIPLCTDIA-------- --YNQTIMPNLLGHTSQEDAGLEVHQ--FYPLVKVQCSPELKFFLCSMYAPVCT-VLEQAIPP--CRSICERARQGCEAL MNKFGFQWPERLRCE----------------------------------NFPRHGTE-QICVGQ-------NHSEEG--- ----ASPALVTSATPIAGHGTVG--------------------------------------------------------- ------PPRYATLDHPFHCPRVLKVP-------------------TYLNYKFLG---------EKDCAAPCEPAKSD-GH MFFNQEEIRFARIWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLEERVVCNERF--- ----------------------------------QDDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPLRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHGG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWIS-----QNCKS----- -LAIPCPLQY-------------TPR-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSKH-- --GET----------------------------------------------TV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Anolis_carolinensis_(Lizard)FZD3(Scaffold_GL343529.1:_88496-124332) --------------------------------------------------------MAANWVMQFIWPLAVLVGCTSGHS LFS--------------------------------------------------------CEPIILRMCQDLP-------- --YNSTFMPNLLNHYDQQTAALAMEP--FHPMVNLECSREFRPFLCALYAPVCMEYGRVTLP---CRRICQRAYNDCSKL MEMFGVSWPEDMECS----------------------------------KFPDCDEPYPRLVD----------------- ------LNVVGESTEEAPVA------------------------------------------------------------ ----------VQRDYGFWCPRELKIDPDL-------------------GYTFLRVR---------DCSPPCP-------N MYFRREELAFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPT- -----------------------------------TYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAA VPKWGSEAIEKKALLFHTSAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGII SLNRVRIEIP-----LEKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAYRGVWETTWIQE-----RCKE----- -YHIPCP--------------YQVTQ----MSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKD--- VVNESRQVLQE-PDFAQ---SLLRDPNT-----------------------PIIRKSRGTSTQGTSTHASSTQLAMMDD- -------------QRSKAG---SVHSKVSSYHGSLHRSRDGR----------------YTPCSYRGIEDRLPHG------ -------------SMSRL-TDHSRHSSSHRLNDQSRHGSARDLSGNPTTHIT-HGTSMNRVIEEDGTSA----------- ------- >Anolis_carolinensis_(Lizard)FZD4(Chromosome_3:_200019382-200029207) ----------------------------------------KADGGAGGWAMAPGGRLLLG---LLWAALVSGEGARGFGD E-E-----------------------------------------------------ERRCDPIRIPMCQNLG-------- --YNVTKMPNLVGHDLQTDAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKIDIPIGS--CGGMCLSVKRRCEPV LKEFGFSWPESLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDEE------ -----------VPIHSKT-------------------------------------------------------------- -----------PLHPGEECHSVGANSD---------------------QYIWVKRS--------LNCVLKCGYD----AG LYS-RSAKAFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF---- ---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLV ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWTIFRYSADD--------------- ---------------------------------SNMAVEMLKIFMCLLVGITSGMWIWSAKTLHTWQK--CSNRLV---- --------------------------------------------------NSGRVKRGEKRAN------GWVKPGKGNET VV------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Anolis_carolinensis_(Lizard)FZD5(Scaffold_GL343343.1:_194929-197396) ----------------------------------------PLPPPPAPPPRR-----------PFLLLAHIQERARASSS SKAVT------------------------------------------------------CQEITVPMCKGIG-------- --YNLTYMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSPDLKFFLCAMYTPICLLDYAKPLPP--CRSVCERAKAGCSPL MRQYGFAWPERMGCD----------------------------------KLPLLG-DAEQLCMD------YNRTEAAPAS A---TTTFPPIGTKPTRSKAKGG--------------------YKEKAPFDSSS-------------------------- --------GTCKRVCECREPLVPISKE------------------THPLYNKIETG------HVRNCAIPCFQP------ -YFTQHEKTFATFWIGLWSVLCFVATFATVATFLIDMERFRYPERPIIFLSACYLFVSIGYIIRLVVGHANVAC------ ----------------------------------NKDYNHIHYETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAA GMKWGNEAIASYSQYFHMAAWLIPSIKSIAVLALSSVDGDPVAGICYVGNQNLDKLRGFVLAPLVVYLFTGTMFLLAGIV SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTVLYTVPATIVVGCYIYEQHYRETWEMAQNCS-------------- -----CPG--------------DKNR-----LRPDYAVFMLKYFMCLVVGITSGVWIWSGKTFESWKRFTGRCCR----- ------SGKPVSS---------------------------AMYGEAT---AALT-GRSGMPSS-----ASYHKQVPLSHV -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Anolis_carolinensis_(Lizard)FZD6(Chromosome_4:_13723379-13739450) ----------------------------------------------------------MTTIH-LLLTWSLIFSLAHGHS LFT--------------------------------------------------------CEPIHIPRCTAMA-------- --YNMTFFPNIMGHYDQYTAAIHMKP--FLPLMNIECSPDVCTFLCKAFVPLCVEPARVIHP---CRSLCERVYSDCKKY MDTFGITWPEELECN----------------------------------RLEDCDETAAVTPS----------------- ------VTTRAHGTRKTLRQ------------------------------------------------------------ ----------PRRDYGFWCPRHLQTSRGQ-------------------SYKFLGID---------QCAPPCP-------N MYFSDHELDVATSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVSLVYFLGFLLGNRIACNQIDEK- -----------------------------------LQLSATVVLGSQNKGCTIVFMALYFFTMAGTVWWVILTVTWFLAA GRKWSCEAIEQKAMWFHAVAWGMPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDTSRFFVLLPLCLCVFVGLSLLLAGII SLNHVRQVIQ-----HDGRNQEKLKKFMIRIGVFSGLYLVPLVMLLGCYIYEQVYRKIWEITWVYD-----HCDE----- -FHIPCP--------------YQVKT----LARPEIFLFLMKYLMTLIVGISPVFWVGSKKTCSEWANFFNRNRKRDP-- -ISESRRVLQESCEFFLKHNSTTKHRKK--------------HYKSSSHKLKVISKSMGTSTGVT-TNHGTSAVAIANHD Y----------LSQETFTEIKSCPGSSEKNLEADGAPSQKVEEELA----------HSVQSGLSMGTSPKVPLEHLEKTS KADN--VQNIS-FSESMKRAAEGRTTPKSDFIEALPLQISHPPLDVSQAG-SLKGSASLFAHSSSDSRKAQESGHSSNG- ------- >Anolis_carolinensis_(Lizard)FZD7(Scaffold_GL343208.1:_4038808-4040586) ----------------------------------------LLPPPLASSSSP-MPRAPAMG-LWGLLALSWMMPHASRGQ PASS---------------------------------------SSSQGEKGISVPDHGFCQPISIPLCTDIA-------- --YNQTILPNLLGHTSQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLEQAIPP--CRSLCERARHGCEAL MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDTSSSS GGERRGAGVAPGSPATASYPTAH--------------------LPGPPAHPL---------------------------- --PP----TTGHAVFEFSCPRQLKVP-------------------PYLGYRFLG---------ERDCGAPCEPDLPNVGL MYFKQAEVRFARLLIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYVAGFLLEDRVVCVERF--- ----------------------------------SEDGFRTVVQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMGQVDGDVLSGVCYVGLYSVDALRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFRDTWEKTWLL-----QNCKS----- -YAITCPAA-------------NFAP-----MSPDFTVFLIKYLMTMIVGITTGFWIWTGKTLQSWRRFYHRLSTGSK-- --GET----------------------------------------------AV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Anolis_carolinensis_(Lizard)FZD8(Chromosome_6:_10678703-10680740) ---------------------------------------RARFPSPSMDRSL-----------LLALLALLPAS-ASASS SASLS------------------------------------------------------CQEITVPLCKGIG-------- --YNYTSMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSSDLRFFLCSMYTPICLEDYKKPLPP--CRSVCERAKAGCAPL MRQYGFAWPDRMRCD----------------------------------RLPAQG-DPDTLCMD------YNRSE----- ----AATTPPPAPPPQAPPPP------------------PPRAPPRKPLPPLPP-------------------------- --TPPGAPPLCKPDCGARGDARALLPC------------------SRQG-------------RIPNFPWPARI------- -LLHPNERAFTAFWIGLWTIICFLSTFATVSTFLIDMERFKYPERPIVFLAACYLFVSLGYLVRLVAGHEKVACSAGA-- --------------------------------------EHVRYESTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAA GMKWGNEAIASYAQYFHLAAWLLPSVKSIAVLALSSVDGDPVAGICYVGNQSLENLRGFVLAPLLIYLAIGSMFLLAGFV SLFRIRSVIKQQG---GPTKTHKLEKLMIRLGLFTVLYTVPAASVVACLFYEQHNRPRWEATHNCP-------------- -----CLRDQ-----------QPDQA-----RRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWKALCTRCCWASK-- --AAAVGGLGGG--------------------------AGSMYSDIS---TGLT-WRSGTASS-----VSYPKQMPLSQV -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Anolis_carolinensis_(Lizard)FZD10(Chromosome_LGb:_173812-175467) ------------------------------------------------------------------------------ER PG------------------------------------------------------ESRCQPIAIPMCQDIG-------- --YNVTRMPNLMGHEDQREAAIQLHE--FAPLVEYGCHGHLRFFLCSLYAPMCTEQVSAPIPA--CRVMCEQARLKCSPV MEQFTFRWPDSLDCS----------------------------------RLPSKNDPNFLCMEAP-----SNGS-----E EPPK-PGPLPPLFRPHRP---HE--------------------------------------------------------- ----------HEP-PPPKGVPSCGNPG---------------------KFRRVEKS--------ASCAPLCSPG----VD VYWSRQDKRFAAVWIGVWSVLCFFSSAFTVLTFLVDPQRFKYPERPIIFLSMCYCVYSLGYLIRLFSGAESVACD----- ---------------------------------RDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVILTLTWFLAA GKKWGHEAIEANSSYFHLAAWAVPAVKTIVILVMRRVAGDELTGVCYVGSMDVDALTGFVLVPLACYLVIGTSFILSGFV ALFHIRRVMKTGG-----ENTAKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWKVLAMQQKCKVNGNQTK---- --HLDCTMSK---------------------SIPAVEIFMAKVFMLLVVGITSGMWIWTSKTLQSWQN-VCSQRLK---- --------------------------------------KRTRRKPASVIASSGLYQKTQHPPK---GHHTKYESALQPPT CV------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Oryzias_latipes_(Medaka)FZD1(frizzled7)(Chromosome_21:_18907323-18910690) ---------------------------------------------IFARRYSPAFFATFF------VFTPRLCMPAASAQ HY---------------------------------------------SDSGISVPEHGFCQPISIPLCTDIA-------- --YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSTELKFFLCSMYAPVCT-VLEQAIPP--CRSLCERARQGCEAL MNKFGFQWPERLHCE----------------------------------AFPVNGGS-EICVGQ-------NTSEPG--- -------SPSSSS-PHVPE------------------------LVTVPPNR----------------------------- --FPNPPQPPHNSYHQFSCPLQLEVP-------------------SYLGYRFMG---------VKDCGAPCEPTKPS-GI MYFREDEVKFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLEDKVVCVDKF--- ----------------------------------KGEGFRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLSA GMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMGQVDGDVLTGVCFVGIFNVDALRGFVLAPLFVYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERTWHM-----QTCKR----- -FAVPCPVH-------------NFAP-----MTPDFTVFMIKYLMTMIVGITSGFWVWSGKTLQSWRRFYKRLGNGNH-- --GET----------------------------------------------TV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Oryzias_latipes_(Medaka)FZD2(Chromosome_8:_6503962-6505738) --------------------------------------------RKGRRLLFRSETPRSS------LWFLCLT--AVISA QHQ--------------------------------------------GDDGLMLPPHGFCQQISIPLCTDIA-------- --YNQTIMPNLMGNHNQEDAGLEVHQ--FFPLVKVQCSPELKFFLCSMYAPVCT-VLEKPIPP--CRPICEKARQGCEAL MNKFGFQWPEKLRCE----------------------------------NFPLLGDHGQICVGQ-------NESSSP--- ------------TAPPPLPPAPGTR------------------------------------------------------- -----ELPRVSTHERPFTCPSVLRVP-------------------PYLNYHFLE---------EKDCGAPCESPRNG-GN MFFSDKEIHFARMWVLIWSVLCCTSTFFTVTTYLIDMQRFRYPERPIIFLSGCYTMVSIAFIAGYFLGDKVACNDSF--- ----------------------------------NPDGYKTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA GMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMGQIEGDVLSGVCFVSLSNLDPLRGFVLAPLFIYLFIGTSFLLAGFV SLFRIRTIMKHDG-----TKTEKLEQLMVRIGVFSVLYTVPATIVIACFFYEQAFRPHWERSWVS-----RNCRS----- -LAIPCPAQS-------------RPH-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTSGKN-- --GET----------------------------------------------TV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Oryzias_latipes_(Medaka)FZD3(Chromosome_24:_12909727-12925641) ----------------------------------------------------MDALWVLSLSMLTACVAIPMDAAAGSHS LFT--------------------------------------------------------CEPITLRMCQELP-------- --YNATFMPNIMNHYDQQTAALAMEP--FHPMVNLRCSPDLRMFLCALYAPVCTEYGRMTLP---CRRLCLQAKSDCYKL MEMFGVSWPDEMDCI----------------------------------RFPDCDDPYPRPAD----------------- ------LLSSSDTT-ESPIS------------------------------------------------------------ ----------VQRDYGFWCPRELKISPEL-------------------GYSFMGVR---------DCSPPCP-------N MYFTREELAFARYFIGVVSIVCLSATLFTFLTFLIDVARFRYPERPIIFYAVCYMMVSLVFFLGFLLENKVSCNTASPG- -----------------------------------KFRASTVTQGSHNKACTLLFMVLYFFTMAGSIWWVILTITWFLAA VPKWGSEAIEKKALLFHACAWGVPGILTVTLLAMNKIEGDGMSGVCFVGLYDLTALRWFLLAPLGLDVVVGVVLLLAGIA ALNRVRMEIP-----LEKENREKLVKFMIRIGVFSVLYLVPLLTVLACYLYESSYRALWETSWVQR-----ECRR----- -YHIPCP--------------YQVER----TSHPDLVLFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFFNGKRRKQ--- MVNDSRQVLQE-PDFAQ---LLYRDPNT-----------------------PIVRKSRGTSTQGTSTHASSTHLAMLDEP ----------PSGSTSRAGSVRSARSKMSSYHGSLHRSRDGR----------------YTGSSFRAPNDRPPFGSLPRLN AQSR-------HCSTNRL-DSLSRHGSTLRLESQSQHSSIRDLSPATQAVLS--GNGIRRVMEEDGA------------- ------- >Oryzias_latipes_(Medaka)FZD4(Chromosome_13:_20982376-20988350) ---------------------------------WPRVGPGNPTPAPGLVRLSAGALLLLLR-----ALC----AVNAFGD EME-----------------------------------------------------EMTCDPIRISMCQGLG-------- --YNVTKMPNLVGNMLQSDAELQLTT--FTPLIQCGCSSQLKFFLCSVYVPMCTDKVPIPIGP--CGSMCLSVKRKCLPV LLEFGYTWPEALNCS----------------------------------RFPPQNDHNHMCMEGP-----GDED------ -----------PPYQSVH-------------------------------------------------------------- -----------HPSDQ-DCQALDSTPD---------------------QYTWLKQT--------ESCVLQCGYD----NG LYR-RGAKVFTDAWMAVWAVLCFLSTTLTVLTFLLDSQRFSYPERPIIFLSMCCNLYSVAYLVRLTLGRERVSCDL---- ---------------------------------DAVGVPVLVQEGLKSTGCAIVFLLLYFFGMASSLWWVILTLTWFLAA GLKWGHEAIEMHSSYFHIAAWAIPAAKTIVILIMRLVDADDLTGLCYVGNQQQEALTGFVVAPLATYLLVGTLFICAGLM ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSILYTVPASTVIGCYLYQLSHWGEFKTSTHD--------------- ---------------------------------SYVTSEMLRIFMSLLVGITSGMWIWSAKTLHTWQR--CSSRLL---- --------------------------------------------------REGHVGRGGKSAPG----EGWIKPGKGNET VV------------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------- >Oryzias_latipes_(Medaka)FZD6(Chromosome_16:_1120316-1132396) -------------------------------------------------------------PL-WLGLALVWVGSCRAHS FFT--------------------------------------------------------CEPIKVHRCMGMP-------- --YNMTFFPNMMEHYDQEIAASKMEP--FMPLANLRCSPDVHHFLCQAFIPACTEDNRVIRP---CREKCRAVLSDCREN IRIFDVTWPPELQCD----------------------------------K---LDPCVVDGSV----------------- ------PPTTA--QQTPSS------------------------------------------------------------- ----------PKRDLGFWCPLQLKTKAGQ-------------------GSSFLGTQ---------DCAPPCS-------N MFFKPHDIEFAKSFIGVCSIICLCATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVSLIYFIGFLLGDSAACAKASHH- -----------------------------------AAV-DTVVLGSQSKGCTLLFMLLYFFTMAGMVWWVILTITWFLAA GPKWSCEAIEKKAVWFHSAAWGIPGALTVMLLALNKVEGDSISGVCFVGLYDLDALRYFVLAPLCVGVIVGLILILAGIV SLNHVRQVIQ-----HDERNQEKLKKFMIRIGVFSCLYLLPLVTLLACYTYEQSHRSSWENTWIND-----RCQE----- -YSIPCS--------------YKTAT----PDRPDLSLFLVKYLMTLVVGISAVFWVSSKKTCSEWAYFFNRTRKRDP-- -ISESRRVLQESCEFFLKHNTRVQHKKK--------------HYKSSSHKLKVISKSMGTSTGAAPTNAGTTSSS-GNHE T----------LLEGSLSDTLVR--EQMDRTTAARSSRRGEREG--------------GERRSKGGSSSRISSHSESVHR AADG--RWDETSRSHSER-------------------------------------------------------------- ------- >Oryzias_latipes_(Medaka)FZD8(Chromosome_20:_6877160-6878737) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------DTQDEAGLEVHQ--FWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPP--CRSVCERARAGCAPL MRQYGFPWPDRMRCD----------------------------------LLPVQG-NPDTLCMD------YNRND----- ----STTASPVLSKPTNHPGRSP-------------KSKPGRAGA---PGKYKP-------------------------- ------PAAPCEPGCRCLEPMVAVTTE------------------RHPLYNRVKTG------QVTNCAMPCHNP------ -YFTHDERAFTAFWIGLWSVLCFVSTFATVATFLIDMERFKYPERPIIFLSACYMFVSVGYIVRLIAGHEKVACNR---- ---------------------------------DFDVEH-IHYETTGPALCTIVFLLIYFFGMASSIWWVILSLTWFLAA GMKWGNEAIASYAQHFHLAAWLIPSMKSIAVLALSSVDGDSVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFV SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTVLYTVPATVIVACYFYEQHNRQDWEMTHNCSS------------- -----CLMER-----------ERARS-----G-PDYAVFMLKYFMCLLVGITSGVWIWSGKTLDSWRTFCTRCCWGSK-- --GT----------------------------------GGSMYSDAS---TGLT-WRSGTASS-----VSCRKQMPLS-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------- >Oryzias_latipes_(Medaka)FZD9(Chromosome_13:_21969998-21971728) ----------------------------------------------------------FLWALLPVSASSLEMSFYDLER DR------------------------------------------------------PAKCEPIVIPMCVGIG-------- --YNLTRMPNFMDHDDQAEAAIKLQE--FAPLVDYGCDVHLRFFLCSLYAPMCTDKVSTSIPA--CRPMCEQARDKCAPI MKKFSYTWPDSLDCS----------------------------------KLPTRNDPNALCMEAP-----ENETRTEGKK DKKKGEGMLPVPPRPRQPD------------------------------------------------------------- ----------TPSSRLPGSGNSCENPD---------------------KFQFVEKS--------QSCAPRCSPA----VD VYWSRQDKDFAFIWMTVWSILCFVSTAFTVLTFLLEPHRFQYPERPIIFLSMCYMVYSLAFIIRSVAGAENIACD----- ---------------------------------REHGELYIIQEGLESTGCTIVFLILYYFGMASSIWWVILTLTWFLAA GKKWGHEAIEAHSNYFHMAAWGIPALKTIVILTMRKVAGDELTGLCYVGSMDSGALTGFVLIPLSCYLIIGTSFILTGFV ALFHIRKVMKTEG-----TNTEKLEKLMVKIGIYSILYTVPATCVIVCYFYERLNMDYWKLRGLQEECDSFSSH-