>Rattus_norvegicus(Rat)CDK1(Chromosome_20:_20018044-20044030) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MEDYIKIEK- ----------------------------------IGEGTYGVVYKGRHR----------------TTGQIVAMKKIRLES EE---EGVPSTAIRE---ISLLKELRHPNIVSLQDVLMQD------------------SRLYLIFEFLSMDLKKYLDSIP PGQFMDSSLVK------------------------------------------------------------SYLYQILQG IVFCHSRRVLHRDLKPQNLLIDD-KGTIKLADF--GLARAFGIPIRVYTH------------------------------ --------------EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL------------------------------- ------------------ATKKPLFHGDSE------IDQLFRIFR----------ALGTPNNEVWPEVESLQDYKNTFPK WKPGS--LASHVKN----------LDENGLDLLSK-----MLVYDPAKRISGKMALKHPYFDDLD------NQIKKM--- -------------------------------------------------------------------------------- --------------------------------------------------------- >Rattus_norvegicus(Rat)CDK2(Chromosome_7:_2000197-2007682) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MENFQKVEK- ----------------------------------IGEGTYGVVYKAKNK----------------LTGEVVALKKIRLDT ET---EGVPSTAIRE---ISLLKELNHPNIVKLLDVIHTE------------------NKLYLVFEFLHQDLKKFMDAS- ALTGIPLPLIK------------------------------------------------------------SYLFQLLQG LAFCHSHRVLHRDLKPQNLLINA-EGSIKLADF--GLARAFGVPVRTYTH------------------------------ --------------EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNG-RHSLCPLCSYL EVAASQGGGMTAVSTPYPVTRRALFPGDSE------IDQLFRIFR----------TLGTPDEVVWPGVTSMPDYKPSFPK WARQD--FSKVVPP----------LDEDGRSLLSQ-----MLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Rattus_norvegicus(Rat)CDK4(Chromosome_7:_67016944-67019175) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------Q------------------------------------------------------------DLMRQFLSG LDFLHANCIVHRDLKPENILVTS-NGTVKLADF--GLARIYSYQMALTPV------------------------------ ---------------VVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRK--------------------------- ----------------------PLFCGNSE------ADQLGKIFD----------LIGLPPEDDWPREVSLPRGAFSPRG PRPVQ----SVVPE----------MEESGAQLLL-----EMLTFNPLKRISAFRALQHSYLHKEESDPE----------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Rattus_norvegicus(Rat)CDK5(Chromosome_4:_6119704-6124183) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MQKYEKLEK- ----------------------------------IGEGTYGTVFKAKNR----------------ETHEIVALKRVRLDD DD---EGVPSSALRE---ICLLKELKHKNIVRLHDVLHSD------------------KKLTLVFEFCDQDLKKYFDSC- NG-DLDPEIVK------------------------------------------------------------SLLFQLLKG LGFCHSRNVLHRDLKPQNLLINR-NGELKLADF--GLARAFGIPVRCYSA------------------------------ --------------EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANA---------------------------- --------------------GRPLFPGNDV------DDQLKRIFR----------LLGTPTEEQWPAMTKLPDYKPYPMY PATT-----SLVNV-------VPKLNATGRDLLQN----LLKCNP-VQRISAEEALQHPYFSDFCPP------------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Rattus_norvegicus(Rat)CDK6(Chromosome_4:_27357451-27454089) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------IK------------------------------------------------------------DMMFQLLRG LDFLHSHRVVHRDLKPQNILVTS-SGQIKLADF--GLARIYSFQMALTSV------------------------------ ---------------VVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAELFRRK--------------------------- ----------------------PLFRGSSD------VDQLGKILD----------VIGLPGEEDWPRDVALPRQAFHSKS AQPIE----KFVTD----------IDELGKDLLL-----KCLTFNPAKRISAYGALNHPYFQDLERYKDNLH--SHLSSS QSTSELNTA----------------------------------------------------------------------- --------------------------------------------------------- >Rattus_norvegicus(Rat)CDK14(Chromosome_4:_25352280-25942686) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------MQQYTKGKAS----------------------------- -------------------------------------------------------------------------------- -------------KLT-S--LLKGLKHANIVLLHDIIHTK------------------ETLTLVFEYV------------ -----------------------------------------------------------------------LFLFQLLRG LSYIHQRYILHRDLKPQNLLISD-TGELKLADF--GLARAKSVPSHTYSN------------------------------ --------------EVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQ----------------------------- --------------------GVAAFPGMKD-----IQDQLERIFLV----------LGTPNEDTWPGVHSLPHFKP-ERF TVYSS----KSLRQ---AWNKLSYVN-HAEDLASK-----LLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTV PNVRLQPEAGESMRA--FGKNNS---------------YGKSLSNSKH-------------------------------- --------------------------------------------------------- >Rattus_norvegicus(Rat)CDK15(Chromosome_9:_57840625-57930096) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MGQELCAKSRQPGCSCYHRSEGGEAHSCQRSQ--------------------------------------- --------------------------PGSTSEPAVFE--LKEASCSSA--SFHPRGLQAARVQKLESKRPR--------- --------------------------------------------SNSDSFQEENLRQGVPW-KLRLTLGQPSSYLSHSR- ----------------------------------DGTQGWLKCTRGIR----------------RINGQLVALKVISMNA E----EGVPFTAIREA-S--LLKGLKHANIVLLHDIVHTK------------------ETLTFVFEYMHTDLAQYMSQH- PG-GLHPHNVR------------------------------------------------------------LFMFQLLRG LAYIHHQRVLHRDLKPQNLLLSH-LGELKLADF--GLARAKSIPSQTYSS------------------------------ --------------EVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQ----------------------------- --------------------GQPLFPGVSN-----ILEQLEKIWEV----------LGVPTEDTWPGVSKLPNYNP-EWF PPPEP----QSLQT---VWNRLGGVP-EAEDLASQ-----MLKGFPRDRVSAQEALVHDYFSVLPSQLYQLPDEESLFAV SGVELKPEMCDLSAS--YRKGHL---------------LAG-VNKCW--------------------------------- --------------------------------------------------------- >Rattus_norvegicus(Rat)CDK16(Chromosome_X:_12909984-12916478) -------------------------------------------------------------------------------- ----------------------MDRMKK------------IKRQLSMTLRGGRG----------------IDK------- ------TNGVPEQIGLDESGGGGGS--------DLGEAPTR-------VAPGELRSIRGPLSSAP--------------- ------------------EIVHEDMKMGSDGESDQASATSSDEVQSPV------RVRMRNHPPRKISTE----------- -------------------DINKRLSLPADIRLPEGYLEKLTLNS--PIFDKPLSRRLRRVSLSEIGFGKLETYIKLDK- ----------------------------------LGEGTYATVYKGKSK----------------LTDNLASSQKTKADY E----NVLSCECKSEL--VSLLKDLKHANIVTLHDIIHTE------------------KSLTLVFEYLDKDLKQYLDDC- GN-VINMHNVK------------------------------------------------------------LFLFQLLRG LAYCHRQKVLHRDLKPQNLLINE-RGELKLADF--GLARAKSIPTKTYSN------------------------------ --------------EVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMAT----------------------------- --------------------GRPLFPGSTV------EEQLHFIFR----------ILGTPTEDTWPGILSNEEFRTYNYP KYRAE----ALLSH-------APRLDSDGADLLTK----LLQ-FEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFAL KEVQLQKEA--NIRSTSMPDSG----------------RPA-FRVVDTEF------------------------------ --------------------------------------------------------- >Rattus_norvegicus(Rat)CDK17(Chromosome_7:_30194242-30272352) -------------------------------------------------------------------------------- -------------------------MKK------------FKRRLSLTLRGSQT----------------IDES------ ------LSELAEQMTIEE-SSSKDN---EPIVK-NGRPPTS------HSMHSFLHQYTGSFKKPPLR-----RPHSVIGG SLG---SFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPT------GVCLRNRIHRRISME----------- -------------------DLNKRLSLPADIRIPDGYLEKLQISS--PPFDQPMSRRSRRASLSEIGFGKMETYIKLEK- ----------------------------------LGEGTYATVYKGRSK----------------LTENLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIVHTD------------------KSLTLVFEYLDKDLKQYMDDC- GS-IMSMHNVK------------------------------------------------------------LFLYQILRG LAYCHRRKVLHRDLKPQNLLINE-RGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMAS----------------------------- --------------------GRPLFPGSTV------EDELHLIFR----------LLGTPSQETWPGVSSNDEFKNYNFP KYKPQ----PLINH-------APRLDSEGIELITK----FLQ-YESKKRAPAEEAMKHVYFRSLGPRIHALPESVSIFSL KEIQLQKDP--GFRNSSYPETG----------------HGK-NRRQSMLF------------------------------ --------------------------------------------------------- >Rattus_norvegicus(Rat)CDK18(Chromosome_13:_44996448-45004813) -------------------------------------------------------------------------------- ----------------------MNKMKN------------FKRRLSLSVPRPET----------------IEES------ ------LTEFTEQFNQLHTQRNE--------------------------------------------------------- -----------------------------------DGRDEPGQLSPG-------VQYQQRQNQRRFSME----------- -------------------DLNKRLSLPMDIRLPQEFLQKLQLEN--PGLPKPLTRMSRRASLSDIGFGKLETYVKLDK- ----------------------------------LGEGTYATVFKGRSK----------------LTENLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDLIHTD------------------RSLTLVFEYLDSDLKQYLDHC- GN-LMNMHNVK------------------------------------------------------------IFMFQLLRG LAYCHRRKILHRDLKPQNLLINE-RGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMAT----------------------------- --------------------GKPLFPGSTV------KEELHLIFR----------LLGTPTEESWPGVTSISEFRAYNFP RYLPQ----PLLSH-------APRLDTEGINLLTS----LLL-YESKSRMSAEAALSHPYFQSLGERVHQLDDTASIFSL KEIQLQKDP--GYRGLAFQHPG----------------RGK-SRRQSIF------------------------------- --------------------------------------------------------- >Gallus_gallus_(Chicken)CDK1(cell_division_cycle_2)(Chromosome_6:_9821486-9829491) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MEDYTKIEK- ----------------------------------IGEGTYGVVYKGRHK----------------TTGQVVAMKKIRLES EE---EGVPSTAIRE---ISLLKELHHPNIVCLQDVLMQD------------------ARLYLIFEFLSMDLKKYLDTIP SGQYLDRSRVK------------------------------------------------------------SYLYQILQG IVFCHSRRVLHRDLKPQNLLIDD-KGVIKLADF--GLARAFGIPVRVYTH------------------------------ --------------EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL------------------------------- ------------------ATKKPLFHGDSE------IDQLFRIFR----------ALGTPNNDVWPDVESLQDYKNTFPK WKPGS--LGTHVQN----------LDEDGLDLLSK-----MLIYDPAKRISGKMALNHPYFDDLDKSTLPANLIKKF--- -------------------------------------------------------------------------------- --------------------------------------------------------- >Gallus_gallus_(Chicken)CDK3(Chromosome_18:_4565637-4570128) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------FCCFFFSPFRASSHKAEAMEAFQQVFQKVEK- ----------------------------------IGEGTYGVVYKARNK----------------RTGQLVALKKIRLDA ET---EGVPSTAIRE---ISLLKELKHPNIVRLLDVVHSQ------------------KKLYLVFEYLNQDLKKYIDSS- QTGEFPLSLVK------------------------------------------------------------NYLFQLLQG VSFCHSHRVIHRDLKPQNLLINE-AGAIKLADF--GLARAFGVPLRTYTH------------------------------ --------------EVVTLWYRAPEILLGCKYYSTAVDIWSIGCIFAEM------------------------------- ------------------VTRKALFQGDSE------IDQLFRIFR----------TLGTPTEATWPGVSQLPDYKGDFPQ WARKE--MKEIVPN----------LDRHGRDLLAQ-----LLLYDPSKRISAKAALSHQYFFRKSPQSTEEQHVQQRHCR -------------------------------------------------------------------------------- --------------------------------------------------------- >Gallus_gallus_(Chicken)CDK6(Chromosome_2:_22665630-22784767) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MDKDGTNLADQ-----------------QYECVAE- ----------------------------------IGEGAYGKVFKARDLKNG---------------GRFVALKRVRVQT S---EEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVS-RTDRE------------TKLTLVFEHVDQDLTTYLDKV- PEPGVPTETIK------------------------------------------------------------DMMLQLFRG LDFLHSHRVVHRDLKPQNILVTS-SGQIKLADF--GLARIYSFQMALTSV------------------------------ ---------------VVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRK--------------------------- ----------------------PLFRGNSD------VDQLGKIFD----------VIGLPEEEDWPNDVALPRNAFASRP AQPIE----KFVPD----------IDDMGKDLLL-----KCLAFNPAKRISAYAALSHPYFHDLEKCKENLD--SHMSSS QNSSEVNAS----------------------------------------------------------------------- --------------------------------------------------------- >Gallus_gallus_(Chicken)CDK14(Chromosome_2:_21735469-21982864) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MKKLRRTLSESFSRIALKKEDSSFDEICVTKMSTRNCQG--------------------------------------- --------------------------MDSVIKPLDTIPEDKKVRVQRTQSSFDPFEKPTNQVKRVHSENNACI------- ----------------------------------------NFKTSSAGKESPKVRRHSSPSSPTSPKFGKADSYEKLEK- ----------------------------------LGEGSYATVYKGKS----------------KVNGKLVALKVIRLQE E----EGTPFTAIREA-S--LLKGLKHANIVLLHDIIHTK------------------ETLTLVFEYVHTDLCQYMDKH- PG-GLHPENVK------------------------------------------------------------LFLFQLLRG LSYIHQRYILHRDLKPQNLLISD-TGELKLADF--GLARAKSVPSHTYSN------------------------------ --------------EVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQ----------------------------- --------------------GVAAFPGMKD-----IQDQLERIFLV----------LGTPNEDTWPGVHSLPHFKP-ERF TQYSP----KNLRQ---AWNKLSYVN-HAEDLASK-----LLQCFPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTV PNVRLQAETGESMRV--FGKNNS---------------YGKGVSNSKH-------------------------------- --------------------------------------------------------- >Gallus_gallus_(Chicken)CDK15(Chromosome_7:_12643464-12676391) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------VP--SQQPQHFHTLQSRRCRMWRPW--------- --------------------------------------------TYNDHFKEQDVVESFKWQRQGIPFGAATSYVHLKK- ----------------------------------LCEGSSATVYKGIS----------------RINGQLVALKVISLET E----EGVPFTAIREA-S--LLKHLKHANIVLLHDIIQTK------------------ETLTFVLEYMHTDLAQYMAQH- PG-GLHPCNVM------------------------------------------------------------LFMFQLLRG LAYIHRQHILHRDLKPQNLLISC-LGELKLADF--GLARAKSIPSQTYSS------------------------------ --------------EVVTLWYRPPDVLLGATDYSSDLDIWSAGCVFVEMVQ----------------------------- --------------------GQPVFAGTSS-----APEQLEKIWTV----------LGVPTEDTWPGLSKLPKYKP-AFW PVLIS----CTIFP---RFARLSRAP-AAEDLASR-----MLTAFPPGRISAQDALLHGFFSPLPPQLYQVPPEQSVLTV PAVRLQPEICDLFTS--YRKGRL---------------SQG-SSKFW--------------------------------- --------------------------------------------------------- >Gallus_gallus_(Chicken)CDK17(Chromosome_1:_47703604-47793707) -------------------------------------------------------------------------------- ----------------------IDRMKK------------FKRRLSLTLRGSQT----------------IDES------ ------LSELAEQMTIEE-NSSKDN---EPIVK-NGRPPTS------HSMHSFLHQYTGSFKKPPLR-----RPHSVIGG SLG---SFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPT------GVCLRNRIHRRISME----------- -------------------DLNKRLSLPADIRIPDGYLEKLQINS--PPFDQPMSRRSRRASLSEIGFGKMETYIKLEK- ----------------------------------LGEGTYATVYKGRSK----------------LTENLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIVHTD------------------KSLTLVFEYLDKDLKQYMDDC- GN-IMSMHNVK------------------------------------------------------------LFLYQILRG LAYCHRRKVLHRDLKPQNLLINE-KGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMAS----------------------------- --------------------GRPLFPGSTV------EDELHLIFR----------LLGTPCQETWPGISSSDEFRNYNFP KYKPQ----PLINH-------APRLDTEGIELIAK----FLQ-YESKKRISAEEAMKHAYFRSLGTRIHSLPESVSIFSL KEIQLQKDP--GFRNSTYPETG----------------HGK-NRRQSMLF------------------------------ --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK1(Chromosome_10:_59157127-59173568) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MEDYTKIEK- ----------------------------------IGEGTYGVVYKGRHK----------------TTGQVVAMKKIRLES EE---EGVPSTAIRE---ISLLKELRHPNIVSLQDVLMQD------------------SRLYLIFEFLSMDLKKYLDSIP PGQYMDSSLVK------------------------------------------------------------SYLYQILQG IVFCHSRRVLHRDLKPQNLLIDD-KGTIKLADF--GLARAFGIPIRVYTH------------------------------ --------------EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL------------------------------- ------------------ATKKPLFHGDSE------IDQLFRIFR----------ALGTPNNEVWPEVESLQDYKNTFPK WKPGS--LASHVKN----------LDENGLDLLSK-----MLIYDPAKRISGKMALNHPYFNDLD------NQIKKM--- -------------------------------------------------------------------------------- --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK2(Chromosome_12:_33392568-33398047) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MENFQKVEK- ----------------------------------IGEGTYGVVYKARNK----------------LTGEVVALKKIRLDT ET---EGVPSTAIRE---ISLLKELNHPNIVKLLDVIHTE------------------NKLYLVFEFLHQDLKKFMDAS- ALTGIPLPLIK------------------------------------------------------------SYLFQLLQG LAFCHSHRVLHRDLKPQNLLINT-EGAIKLADF--GLARAFGVPVRTYTH------------------------------ --------------EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM------------------------------- ------------------VTRRALFPGDSE------IDQLFRIFR----------TLGTPDEVVWPGVTSMPDYKPSFPK WARQD--FSKVVPP----------LDEDGRSLLSQ-----MLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK3(Chromosome_17:_74956206-74961823) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MDMFQKVEK- ----------------------------------IGEGTYGVVYKAKNR----------------ETGQLVALKKIRLDL EM---EGVPSTAIRE---ISLLKELKHPNIVRLLDVVHNE------------------RKLYLVFEFLSQDLKKYMDST- PGSELPLHLIK------------------------------------------------------------SYLFQLLQG VSFCHSHRVIHRDLKPQNLLINE-LGAIKLADF--GLARAFGVPLRTYTH------------------------------ --------------EVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEM------------------------------- ------------------VTRKALFPGDSE------IDQLFRIFR----------MLGTPSEDTWPGVTQLPDYKGSFPK WTRKG--LEEIVPN----------LEPEGRDLLMQ-----LLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFHH -------------------------------------------------------------------------------- --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK4(Chromosome_12:_31595117-31599275) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MATSR--------------------YEPVAE- ----------------------------------IGVGAYGTVYKARDPHS----------------GHFVALKSVRVPN GGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATS-RTDRE------------IKVTLVFEHVDQDLRTYLDKA- PPPGLPAETIK------------------------------------------------------------DLMRQFLRG LDFLHANCIVHRDLKPENILVTS-GGTVKLADF--GLARIYSYQMALTPV------------------------------ ---------------VVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRK--------------------------- ----------------------PLFCGNSE------ADQLGKIFD----------LIGLPPEDDWPRDVSLPRGAFPPRG PRPVQ----SVVPE----------MEESGAQLLL-----EMLTFNPHKRISAFRALQHSYLHKDEGNPE----------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK5(Chromosome_7:_152214130-152218287) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MQKYEKLEK- ----------------------------------IGEGTYGTVFKAKNR----------------ETHEIVALKRVRLDD DD---EGVPSSALRE---ICLLKELKHKNIVRLHDVLHSD------------------KKLTLVFEFCDQDLKKYFDSC- NG-DLDPEIVK------------------------------------------------------------SFLFQLLKG LGFCHSRNVLHRDLKPQNLLINR-NGELKLADF--GLARAFGIPVRCYSA------------------------------ --------------EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANA---------------------------- --------------------GRPLFPGNDV------DDQLKRIFR----------LLGTPTEEQWPSMTKLPDYKPYPMY PATT-----SLVNV-------VPKLNATGRDLLQN----LLKCNP-VQRISAEEALQHPYFSDFCPP------------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK6(Chromosome_7:_93141624-93361040) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MEKDGLCRADQ-----------------QYECVAE- ----------------------------------IGEGAYGKVFKARDLKNG---------------GRFVALKRVRVQT G---EEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVS-RTDRE------------TKLTLVFEHVDQDLTTYLDKV- PEPGVPTETIK------------------------------------------------------------DMMFQLLRG LDFLHSHRVVHRDLKPQNILVTS-SGQIKLADF--GLARIYSFQMALTSV------------------------------ ---------------VVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRK--------------------------- ----------------------PLFRGSSD------VDQLGKILD----------VIGLPGEEDWPRDVALPRQAFHSKS AQPIE----KFVTD----------IDELGKDLLL-----KCLTFNPAKRISAYSALSHPYFQDLERCKENLD--SHLPPS QNTSELNTA----------------------------------------------------------------------- --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK14(Chromosome_7:_91249146-91744768) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQG--------------------------------------- --------------------------MDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACI------- ----------------------------------------NFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEK- ----------------------------------LGEGSYATVYKGKS----------------KVNGKLVALKVIRLQE E----EGTPFTAIREA-S--LLKGLKHANIVLLHDIIHTK------------------ETLTLVFEYVHTDLCQYMDKH- PG-GLHPDNVK------------------------------------------------------------LFLFQLLRG LSYIHQRYILHRDLKPQNLLISD-TGELKLADF--GLARAKSVPSHTYSN------------------------------ --------------EVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQ----------------------------- --------------------GVAAFPGMKD-----IQDQLERIFLV----------LGTPNEDTWPGVHSLPHFKP-ERF TLYSS----KSLRQ---AWNKLSYVN-HAEDLASK-----LLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTV PNVRLQPEAGESMRA--FGKNNS---------------YDKSLSNSKH-------------------------------- --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK15(Chromosome_2B:_206566631-206651716) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MGQELCAKTVQPGCSCYRCSEGGEAHSCRRSQ--------------------------------------- --------------------------PETT-EAAFKLTDLKEASCSMT--SFHPRGLQAVRAQKFKSKRPR--------- --------------------------------------------SNSDSFQEEDLRQGFQW-RKSLPFGAASSYLNLEK- ----------------------------------LGEGSYATVYKGIS----------------RINGQLVALKVISMNA E----EGVPFTAIREA-S--LLKGLKHANIVLLHDIIHTK------------------ETLTFVFEYMHTDLAQYMSQH- PG-GLHPHNVR------------------------------------------------------------LFMFQLLRG LAYIHHQHVLHRDLKPQNLLISH-LGELKLADF--GLARAKSIPSQTYSS------------------------------ --------------EVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQ----------------------------- --------------------GQPLFPGVSN-----ILEQLEKIWEV----------LGVPTEDTWPGVSKLPNYNP-EWF PLPTP----RSLHV---VWSRLGRVP-EAEDLASQ-----MLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTV SGVRLKPEMCDLLAS--YQKGHH---------------PAQ-FSKWW--------------------------------- --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK16(Chromosome_X:_47725466-47737403) -------------------------------------------------------------------------------- --------------------IAMDRMKK------------IKRQLSMTLRGGRG----------------IDK------- ------TNGAPEQIGLDESGGGGGS--------DPGEAPTR-------AAPGELRSARGPLSSAP--------------- ------------------EIVHEDLKMGSDGESDQASATSSDEVQSPV------RVRMRNHPPRKISTE----------- -------------------DINKRLSLPADIRLPEGYLEKLTLNS--PIFDKPLSRRLRRVSLSEIGFGKLETYIKLDK- ----------------------------------LGEGTYATVYKGKSK----------------LTDNLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIIHTE------------------KSLTLVFEYLDKDLKQYLDDC- GN-IINMHNVK------------------------------------------------------------LFLFQLLRG LAYCHRQKVLHRDLKPQNLLINE-RGELKLADF--GLARAKSIPTKTYSN------------------------------ --------------EVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMAT----------------------------- --------------------GRPLFPGSTV------EEQLHFIFR----------ILGTPTEETWPGILSNEEFKTYNYP KYRAE----ALLSH-------APRLDSDGADLLTK----LLQ-FEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFAL KEIQLQKEA--SLRSSSMPDSG----------------RPA-FRVVDTEF------------------------------ --------------------------------------------------------- >Pan_troglodytesChimpanzeeCDK17(Chromosome_12:_96526969-96641793) -------------------------------------------------------------------------------- -------------------------MKK------------FKRRLSLTLRGSQT----------------IDES------ ------LSELAEQMTIEE-NSSKDN---EPIVK-NGRPPTS------HSMHSFLHQYTGSFKKPPLR-----RPHSVIGG SLG---SFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPT------GVCLRNRIHRRISME----------- -------------------DLNKRLSLPADIRIPDGYLEKLQINS--PPFDQPMSRRSRRASLSEIGFGKMETYIKLEK- ----------------------------------LGEGTYATVYKGRSK----------------LTENLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIVHTD------------------KSLTLVFEYLDKDLKQYMDDC- GN-IMSMHNVK------------------------------------------------------------LFLYQILRG LAYCHRRKVLHRDLKPQNLLINE-KGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMAS----------------------------- --------------------GRPLFPGSTV------EDELHLIFR----------LLGTPSQETWPGISSNEEFKNYNFP KYKPQ----PLINH-------APRLDSEGIELITK----FLQ-YESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSL KEIQLQKDP--GFRNSSYPETG----------------HGK-NRRQSMLF------------------------------ --------------------------------------------------------- >Bos_taurus_(Cow)CDK1(Chromosome_28:_16620266-16633922) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MEDYTKIEK- ----------------------------------IGEGTYGVVYKGRHK----------------TTGQVVAMKKIRLES EE---EGVPSTAIRE---ISLLKELRHPNIVSLQDVLMQD------------------SRLYLIFEFLSMDLKKYLDSIP PGQFMDSSLVK------------------------------------------------------------SYLYQILQG IVFCHSRRVLHRDLKPQNLLIDD-KGTIKLADF--GLARAFGIPIRVYTH------------------------------ --------------EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL------------------------------- ------------------ATKKPLFHGDSE------IDQLFRIFR----------ALGTPNNEVWPEVESLQDYKSTFPK WKPGS--LASHVKN----------LDENGLDLLSK-----MLIYDPAKRISGKMALNHPYFNDLD------SQIKKM--- -------------------------------------------------------------------------------- --------------------------------------------------------- >Bos_taurus_(Cow)CDK2(Chromosome_5:_57664374-57669057) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MENFQKVEK- ----------------------------------IGEGTYGVVYKAKNK----------------LTGEVVALKKIRLDT ET---EGVPSTAIRE---ISLLKELNHPNIVKLLDVIHTE------------------NKLYLVFEFLHQDLKKFMDAS- ALTGIPLPLIK------------------------------------------------------------SYLFQLLQG LAFCHSHRVLHRDLKPQNLLINA-DGSIKLADF--GLARAFGVPVRTYTH------------------------------ --------------EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM------------------------------- ------------------VTRRALFPGDSE------IDQLFRIFR----------TLGTPDEVVWPGVTSMPDYKPSFPK WARQD--FSKVVPP----------LDEDGRSLLSQ-----MLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Bos_taurus_(Cow)CDK4(Chromosome_5:_56039291-56042258) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MATSR--------------------YEPVAE- ----------------------------------IGVGAYGTVYKARDPHS----------------GHFVALKSVRVPN GGGAGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATA-RTDRE------------TKVTLVFEHVDQDLRTYLDKA- PPPGLPVETIK------------------------------------------------------------DLMRQFLRG LDFLHANCIVHRDLKPENILVTS-GGTVKLADF--GLARIYSYQMALTPV------------------------------ ---------------VVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRK--------------------------- ----------------------PLFCGNSE------ADQLGKIFD----------LIGLPPEDDWPRDVSLPRGAFSPRG PRPVQ----SVVPE----------LEESGAQLLL-----EMLTFNPHKRISAFRALQHSYLHKAEGDAE----------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Bos_taurus_(Cow)CDK5(Chromosome_4:_114429163-114433469) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MQKYEKLEK- ----------------------------------IGEGTYGTVFKAKNR----------------ETHEIVALKRVRLDD DD---EGVPSSALRE---ICLLKELKHKNIVRLHDVLHSD------------------KKLTLVFEFCDQDLKKYFDSC- NG-DLDPEIVK------------------------------------------------------------SFLFQLLKG LGFCHSRNVLHRDLKPQNLLINR-NGELKLADF--GLARAFGIPVRCYSA------------------------------ --------------EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANA---------------------------- --------------------GRPLFPGNDV------DDQLKRIFR----------LLGTPTEEQWPAMTKLPDYKPYPMY PATT-----SLVNV-------VPKLNATGRDLLQN----LLKCNP-VQRISAEEALQHPYFSDFCPP------------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Bos_taurus_(Cow)CDK6(Chromosome_4:_9792303-10039520) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MEKDGLSRADQ-----------------QYECVAE- ----------------------------------IGEGAYGKVFKARDLKNG---------------GRFVALKRVRVQT G---EEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVS-RTDRE------------TKLTLVFEHVDQDLTTYLDKV- PEPGVPTETIK------------------------------------------------------------DMMFQLLRG LDFLHSHRVVHRDLKPQNILVTS-SGQIKLADF--GLARIYSFQMALTSV------------------------------ ---------------VVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRK--------------------------- ----------------------PLFRGSSD------VDQLGKILD----------VIGLPGEEDWPRDVALPRLAFHSKS PQPIE----KFVTD----------IDEQGKDLLL-----KCLTFNPAKRISAYSALSHPYFHDLERRKENLD--SHLPPS QNSSEMNTA----------------------------------------------------------------------- --------------------------------------------------------- >Bos_taurus_(Cow)CDK16(Chromosome_X:_90853944-90865344) -------------------------------------------------------------------------------- ----------------------MDRMKK------------IKRQLSMTLRGGRG----------------IDK------- ------TNGAPEQIGLDESGGGGGS--------DLGEAPTR-------AAPGEPRSVRGPLSSAP--------------- ------------------EIVHEDLKMGSDGESDQASATSSDEVQSPV------RVRMRNHPPRKISTE----------- -------------------DINKRLSLPADIRLPEGYLEKLTLNS--PIFDKPLSRRLRRVSLSEIGFGKLETYIKLDK- ----------------------------------LGEGTYATVYKGKSK----------------LTDNLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIIHTE------------------KSLTLVFEYLDKDLKQYLDDC- GN-IINMHNVK------------------------------------------------------------LFLFQLLRG LAYCHRQKVLHRDLKPQNLLINE-RGELKLADF--GLARAKSIPTKTYSN------------------------------ --------------EVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMAT----------------------------- --------------------GRPLFPGSTV------EEQLHFIFR----------ILGTPNEDTWPGILSNEEFRTYNYP KYRAE----ALLSH-------APRVDSDGADLLTK----LLQ-FEGRNRISAEDAMKHPFFLSLGDRIHKLPDTTSIFAL KEIQLQKEA--SIRSSSMPDSG----------------RPA-YRVVDTEF------------------------------ --------------------------------------------------------- >Bos_taurus_(Cow)CDK17(Chromosome_5:_60897636-61006980) -------------------------------------------------------------------------------- ----------------------VDRMKK------------FKRRLSLTLRGSQT----------------IDES------ ------LSELAEQMTIEE-NSSKDN---EPIVK-NGRPPTS------HSMHSFLHQYTGSFKKPPLR-----RPHSVIGG SLG---SFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPT------GVCLRNRIHRRISIE----------- -------------------DLNKRLSLPADIRIPDGYLEKLQINS--PPFDQPMSRRSRRASLSEIGFGKMETYIKLEK- ----------------------------------LGEGTYATVYKGRSK----------------LTENLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIVHTD------------------KSLTLVFEYLDKDLKQYMDDC- GN-IMSMHNVK------------------------------------------------------------LFLYQILRG LAYCHRRKVLHRDLKPQNLLINE-KGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMAS----------------------------- --------------------GRPLFPGSTV------EDELHLIFR----------LLGTPSQENWPGVSSNDEFKNYNFP KYKPQ----PLINH-------APRLDSEGIELITK----FLQ-YESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSL KEIQLQKDP--GFRNSSYPETG----------------HAK-TEKHSALF------------------------------ --------------------------------------------------------- >Bos_taurus_(Cow)CDK18(Chromosome_16:_3099023-3108506) -------------------------------------------------------------------------------- ----------------------MSKMKN------------FKRRFSLSVPRTET----------------IEES------ ------LAEFTEQFNQLHNRRNED-------------------------------------------------------- --------------LQLGPLGGDPQPESSTFSPT-DSGKDLGQLSPG-------VQY-RRQNQRRFSME----------- -------------------DISKRLSLPMDIRLPQEFLQKLQLES--PDLPKPLTRMSRRASLSDIGFGKLETYVKLDK- ----------------------------------LGEGTYATVFKGRSK----------------LTENLVALKEIRLEH E----EGAPCTAIRE---VSLLRNLKHANIVTLHDLVHTE------------------RSLTLVFEYLDRDLKQYLDHC- GN-LMSMHNVK------------------------------------------------------------IFMFQLLRG LAYCHRRKILHRDLKPQNLLINE-RGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSTEYSTPLDMWGVGCIQYEMAT----------------------------- --------------------GRPLFPGSTV------KEELHLIFR----------LLGTPTEETWPGVMALTEFRAYNFP RYLPQ----PLLSH-------VPRLDPDGINLLSS----LLL-YESKSRVSAEAALRHPYFRSLGERVHQLEDTASLFSL KEIQLQKDP--GYRGLAFQQPG----------------RGK-NRRQSIF------------------------------- --------------------------------------------------------- >Loxodonta_Africana_(Elephant)CDK1(SuperContig_scaffold_10:_42134622-42147914) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MEDYTKIEK- ----------------------------------IGEGTYGVVYKGRHK----------------TTGQIVAMKKIRLES EE---EGVPSTAIRE---ISLLKELRHPNIVSLQDVLMQD------------------SRLYLIFEFLSMDLKKYLDSIP PGQFMDSALVK------------------------------------------------------------SYLYQILQG IVFCHSRRVLHRDLKPQNLLIDD-KGTIKLADF--GLARAFGIPIRVYTH------------------------------ --------------EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL------------------------------- ------------------ATKKPLFHGDSE------IDQLFRIFR----------ALGTPNNEVWPEVESLQDYKNTFPK WKPGS--LASHVKN----------LDENGLDLLSK-----MLVYDPAKRISGKMALNHPYFNDLD------NQIKKM--- -------------------------------------------------------------------------------- --------------------------------------------------------- >Loxodonta_Africana_(Elephant)CDK2(SuperContig_scaffold_2:_45334514-45339522) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MENFQKVEK- ----------------------------------IGEGTYGVVYKAKNK----------------VTGEVVALKKIRLDT ET---EGVPSTAIRE---ISLLKELNHPNIVKLLDVIHTE------------------NKLYLVFEFLHQDLKKFMDAS- ALTGIPLPLIK------------------------------------------------------------SYLFQLLQG LAFCHSHRVLHRDLKPQNLLINA-EGAIKLADF--GLARAFGVPVRTYTH------------------------------ --------------EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHARCCGEHRRNG-RHSLCPLCSYL EVAASQGGGMTAVSTPHPVTRRALFPGDSE------IDQLFRIFR----------TLGTPDETVWPGVTSMPDYKASFPK WARQD--FSKVVPP----------LDEDGRSLLSQ-----MLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Loxodonta_Africana_(Elephant)CDK4(SuperContig_scaffold_2:_47042740-47044056) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MATPR--------------------YEPVAE- ----------------------------------IGVGAYGTVYKARDPHS----------------GHFVALKSVRVPN GGGTGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATA-RTDRE------------TKVTLVFEHVDQDLRTYLDKA- PPPGLPVETIK------------------------------------------------------------DLMRQFLRG LDFLHANCIVHRDLKPENILVTS-GGTVKLADF--GLARIYSYQMALTPV------------------------------ ---------------VVTLWYRAPEVLLQSA-YATPVDMWSVGCIFAEMFRRK--------------------------- ----------------------PLFCGNSE------ADQLGKI------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Loxodonta_Africana_(Elephant)CDK5(SuperContig_scaffold_12:_59609806-59613530) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MQKYKKLEK- ----------------------------------IGEGTYGTVFKAKNR----------------ETHEIVALKRVRLDD DD---EGVPSSALRE---ICLLKELKHKNIVRLHDVLHSD------------------KKLTLVFEFCDQDLKKYFDSC- NG-DLDPEIVK------------------------------------------------------------SFLFQLLKG LGFCHSRNVLHRDLKPQNLLINR-NGELKLADF--GLARAFGIPVRCYSA------------------------------ --------------EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANA---------------------------- --------------------GRPLFPGNDV------DDQLKRIFR----------LLGTPTEEQWPAMTKLPDYKPYPMY PATT-----SLVNV-------VPKLNATGRDLLQN----LLKCNP-VQRISAEEALQHPYFSDFCPP------------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Loxodonta_Africana_(Elephant)CDK14(SuperContig_scaffold_5:_58373305-58956083) -------------------------------------------------------------------------------- -------------------------------------------------------------------MCDLIEPQPAEKI GKMKKLRRTLSESFSRIALKKEDTTFDEICVTKMSTRNCQG--------------------------------------- --------------------------MDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACI------- ----------------------------------------NFKSSSSGKESPKVRRHSSPSSPTSPKFGKADSYEKLEK- ----------------------------------LGEGSYATVYKGKS----------------KVNGKLVALKVIRLQE E----EGTPFTAIREA-S--LLKGLKHANIVLLHDIIHTK------------------ETLTLVFEYVHTDLCQYMDKH- PG-GLHPDNVK------------------------------------------------------------LFLFQLLRG LSYIHQRYILHRDLKPQNLLISD-TGELKLADF--GLARAKSVPSHTYSN------------------------------ --------------EVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQ----------------------------- --------------------GVAAFPGMKD-----IQDQLERIFLV----------LGTPNEDTWPGVHSLPHFKP-ERF TVYSS----KNLRQ---AWNKLSYVN-HAEDLASK-----LLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTI PNVRLQPETGESMRA--FGKNNS---------------YGKSLSNSKH-------------------------------- --------------------------------------------------------- >Loxodonta_Africana_(Elephant)CDK15(SuperContig_scaffold_3:_24784902-24882782) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MGQELCAKTLHPGCSCYRCSERSKAHSCQRTQ--------------------------------------- --------------------------PVTM-EAAVELTDLKEASCSMT--SFHPEGLQAVRARKFKSKRPQ--------- --------------------------------------------SNSNSFQEGDLKQSLQW-RKSLPFGVASSYLNLEKK ----------------------------------LGEGSYATIYKGIS----------------RINGQLVALKVISMNA E----EGVPFTAIREA-S--LLKGLKHANIVLLHDIIHTK------------------ETLTFVFEYMDTDLAQYMSHH- LG-GLHPHNVR------------------------------------------------------------LFTFQLLRG LAYIHHQHVLHRDLKPQNLLISH-LGELKLADF--GLARAKCILSQTYSS------------------------------ --------------EVVTLWYRPPDALLGATEYSSELEIWGAGCIFIEMFQ----------------------------- --------------------GQPLFPGVSN-----ILEQLEKIWEV----------LGVPTEDTWPGVSKLPNYNP-EWF PLPKP----QSLQM---VWNRLGRVP-EAKDLASQ-----MLKGFPRARVSAHQALVHDYFSALPSQLHQLPNEESLFTV SGVRLKPEICDLLAS--YRKGHH---------------PAR-FSKCW--------------------------------- --------------------------------------------------------- >Loxodonta_Africana_(Elephant)CDK16(SuperContig_scaffold_56:_3259554-3264918) -------------------------------------------------------------------------------- ----------------------MDRMKK------------IKRQLSMTLRGGRG----------------IDK------- ------TNGTPEQIGLDESGGGGGS--------DPGEAPTH-------AVSGEPRSGRGLLSAAQ--------------- ------------------EIVHEDLKMGSDGESD-ASATSSDEVQS-V------RVRMR-TSPTQISTE----------- -------------------DINKRLSLPADIRL-EGYLEKLTLNS--PIFDKPLSRRLRRVSLSEIGFGKLETYIKLDK- ----------------------------------LGEGTYATVYKGKSK----------------LTDNLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIIHTE------------------KSLTLVFEYLDKDLKQYLDDC- GN-VINMHNVK------------------------------------------------------------LFLFQLLRG LAYCHRQKVLHRDLKPQNLLINE-RGELKLADF--GLARAKSIPTKTYSN------------------------------ --------------EVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMAT----------------------------- --------------------GRPLFPGSTV------EEQLHFIFR----------ILGTPTEETWPGILSNEEFKTYNYP KYRAE----ALLSH-------APRLDSDGADLLTK----LLQ-FEGRNRISAEDAMKHQFFLSLGERIHKLPDTTSIFAL KEIQLQKEA--NLRSLSMPDSG----------------RPA-FRVVDTEF------------------------------ --------------------------------------------------------- >Loxodonta_Africana_(Elephant)CDK17(SuperContig_scaffold_2:_90858215-90909718) -------------------------------------------------------------------------------- -------------------------MKK------------FKRRLSLTLRGSQT----------------IDES------ ------LSELAEQMTIEE-NSSKDN---EPIVK-NGRPPTS------HSMHSFLHQYTGSFKKPPLR-----RPHSVIGG SLG---SFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPT------GVCLRNRIHRRISME----------- -------------------DLNKRLSLPADIRIPDGYLEKFQINS--PPFDQPMSRRSRRASLSEIGFGKMETYIKLEK- ----------------------------------LGEGTYATVYKGRSK----------------LTENLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIVHTD------------------KSLTLVFEYLDKDLKQYMDDC- GN-IMSMHNVK------------------------------------------------------------LFLYQILRG LAYCHRRKVLHRDLKPQNLLINE-KGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMAS----------------------------- --------------------GRPLFPGSTV------EDELHLIFR----------LLGTPSQETWPGVSSNDEFKNYNFP KYKPQ----PLINH-------APRLDSEGIELITK----FLQ-YESKKRVSAEEAMKHVYFRSLGPRIHALSESVSIFSL KEIQLQKDP--GFRNSSYPETG----------------HGK-NRRQSMLF------------------------------ --------------------------------------------------------- >Loxodonta_Africana_(Elephant)CDK18(SuperContig_scaffold_13:_10533287-10542587) -------------------------------------------------------------------------------- ----------------------MNKVKN------------FKRRFSLSVPRTET----------------IEES------ ------LAEFTEHFNQLHNQRNE--------------------------------------------------------- -----------------------------------DSGEEPGPPSPG-------TQC-RQQNQRRFSME----------- -------------------DISKRLSLPMDIRLPQEFLQKLQLES--PDLPKPLSRISRRASLSDIGFGKLETYVKLDK- ----------------------------------LGEGTYATVFKGRS-----------------LTENLVALKEXRLEH E----EGAPCTAIRE---VSLLKNLKHANIVTLHDLIHTE------------------RSLTLVFEYLDSDLKQYLDHC- GN-LMSMHNVK------------------------------------------------------------VFMFQLLRG LAYCHRRKILHRDLKPQNLLINE-RGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMAT----------------------------- --------------------GRPLFPGSTV------KEELHLIFR----------LLGTPTEETWPGVTALSEFRTYNFP QYPPQ----PLISH-------APRLDTDGISLLTS----LLL-YESKCRMSAEGALSHAYFRSLGERVHQLEDTASIFSL KEIQLQKDP--GYRGLAFHQPG----------------RGK-GRRQSIF------------------------------- --------------------------------------------------------- >Xenopus_tropicalis_(Frog)CDK1(Scaffold_GL172899.1:_1295672-1302322) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MDEYTKIEK- ----------------------------------IGEGTYGVVYKGRHK----------------ATGQVVAMKKIRLEN EE---EGVPSTAIRE---ISLLKELQHPNIVCLLDVLMQD------------------SRLYLIFEFLSMDLKKYLDSIP SGQYIDTMLVK------------------------------------------------------------SYLYQILQG IVFCHSRRVLHRDLKPQNLLIDS-KGVIKLADF--GLARAFGIPVRVYTH------------------------------ --------------EVVTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEI------------------------------- ------------------ATKKPLFHGDSE------IDQLFRIFR----------YLSISYLVSYPSNHAL----NTFTL WARTH--LN-AIKT----------PSESQKPLIAA-----IKSSGNAQQISARKALLHPYFDDLDKSSLPANQIRN---- -------------------------------------------------------------------------------- --------------------------------------------------------- >Xenopus_tropicalis_(Frog)CDK6(Scaffold_GL172740.1:_1922421-2010674) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MEKD--SLADQ-----------------QYECVAE- ----------------------------------IGEGAYGKVFKARDLKNG---------------GRFVALKRVRVQT G---EEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVS-RTDRE------------TKLTLVFEHVDQDLTTYLDKV- PDPGVPSEIIK------------------------------------------------------------DMMLQLLRG LDFLHSHRVVHRDLKPQNILVTS-NGQIKLADF--GLARIYSFQMALTSV------------------------------ ---------------VVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRK--------------------------- ----------------------PLFRGNSD------VDQLGKIFD----------VIGLPEEEEWPHDVAVPRNAFHFRQ PQPIE----NVVPG----------IDEQGKDLLI-----KCLTFSPANRISAYSALSHPYFHDLQKGKDSVD--SHRPSG QKGVDEGSAG---------------------------------------------------------------------- --------------------------------------------------------- >Xenopus_tropicalis_(Frog)CDK14(Scaffold_GL172740.1:_1013639-1234831) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------ICVTKMSTRNCQG--------------------------------------- --------------------------IDSVIKPLDTIPEDKKVRVQRTQSSFDPFEKTSNQVKRVHSENNACI------- ----------------------------------------NFKSASVGKESPKVRRHSSPSSPTSPKFGKADSYEKLEK- ----------------------------------LGEGSYATVYKGKS----------------KVNGKLVALKVIRLQE E----EGTPFTAIREA-S--LLKGLKHANIVLLHDIIHTK------------------ETLTLVFEYVHTDLCQYMDKH- PG-GLNPENVK------------------------------------------------------------LFLFQLLRG LSYIHQGHILHRDLKPQNLLISD-TGELKLADF--GLARAKSVPSHTYSN------------------------------ --------------EVVTLWYRPPDVLLGSTDYSTCLDMWGVGCIFVEMIQ----------------------------- --------------------GVAAFPGMKD-----IQDQLERIFLI----------LGTPNEETWPGVHSLPHFKL-ERF TQYGP----KNLRQ---AWNKLSYVN-HAEDLASK-----LLQCFPKNRLSAQAALNHDYFSDLPPRLWELSDMSSIFTV PNVKLQPEAGESMRV--FGKNNS---------------FSKSLSNSKH-------------------------------- --------------------------------------------------------- >Xenopus_tropicalis_(Frog)CDK17(Scaffold_GL172975.1:_43636-138299) -------------------------------------------------------------------------------- ----------------------ISNMKK------------FKRRLSLTLRGSQT----------------IDES------ ------LSELAEQMTIEE-NSSKDNGSVEPIVK-NGRPPTS------HSMHSFLHQYTGSFKKPPLR-----RPHSVIGG SLG---SFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPT------GVCLRNRIHRRISME----------- -------------------DLNKRLSLPADIRIPDGYLEKLQINS--PPFDQPMSRRSRRASLSEIGFGKMETYVKLEK- ----------------------------------LGEGTYATVFKGRSK----------------LTENLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIVHTD------------------KSLTLVFEYLDKDLKQYMDDC- GN-IMSIHNVK------------------------------------------------------------IFLYQILRG LAYCHKRKVLHRDLKPQNLLINE-KGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMAS----------------------------- --------------------GRPLFPGSTV------EDELHLIFR----------LLGTPAEETWPGISSNDEFRNYNFP KYKPQ----PVINH-------APRLDSEGIELLTR----FLQ-YESKKRISAEDAMKHAYFRSLGTKIHSLPENISIFSL KDIQLQKDP--GFRNSSYPETG----------------HGK-NRRQSMLF------------------------------ --------------------------------------------------------- >Takifugu_rubripes(Fugu)CDK1(scaffold_2185:_15531-18219) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MEDYLKIEK- ----------------------------------IGEGTYGVVYKGRHK----------------TTGQVVAMKKIRLES EE---EGVPSTAVRE---VSLLQELKHPNVVRLLDVLMQE------------------SRLYLIFEFLSMDLKKYLDSIP PGQYMDPMLVK------------------------------------------------------------SYLYQILEG IYFCHCRRVLHRDLKPQNLLIDN-KGVIKLADF--GLARAFGVPVRVYTH------------------------------ --------------EVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAEL------------------------------- ------------------ATKKPLFHGDSE------IDQLFRIFR----------TLGTPNNDVWPDVESLPDYKNTFPK WKSGN--LS--VKN----------LEKNGLDLLAK-----MLTYNPPKRISARQAMTHPYFDDLDKSTLPSAIINNI--- -------------------------------------------------------------------------------- --------------------------------------------------------- >Takifugu_rubripes(Fugu)CDK4(scaffold_47:_1413283-1416935) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------SV-----------------QYEPVAE- ----------------------------------IGGGAYGTVYKARDTES----------------GKFVALKSVRVQT D---QNGLPVSTVREVALLRRLEQFDHPNVVRLMDVCATQ-RSEQE------------TKVTLVFEHVDQDLKTYLEKA- PAPGLPPGRIK------------------------------------------------------------DLMRQLLCG LAFLHSNRVMHRDLKPENILVTS-QGQVKLADF--GLARIYSCHMVLTPV------------------------------ ---------------VVTLWYRPPEVLLQSS-YATPVDIWSTGCIFAEMFRRK--------------------------- ----------------------PLFCGESE------VDQLGKIIK----------VIGLPSEEEWPTNVTLSRKNFPSAS PSPIT----DFVPE----------INESGAQLLL-----KMLTFDPTKRISALKALEHPYFQKVSLPHTHTH-------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Takifugu_rubripes(Fugu)CDK5(scaffold_107:_33167-35716) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MQKYEKLEK- ----------------------------------IGEGTYGTVFKAKNR----------------ETHEIVALKRVRLDD DD---EGVPSSALRE---ICLLKELKHKNIVRLHDVLHSD------------------KKLTLVFEYCDQDLKKYFDSC- NG-DLDPETVK------------------------------------------------------------SFMHQLLKG LAFCHSRNVLHRDLKPQNLLINR-NGELKLADF--GLARAFGIPVRCYSA------------------------------ --------------EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANA---------------------------- --------------------GRPLFPGNDV------DDQLKRIFRDPLT------LLGTPTEEQWQSMTKLPDYKPYPMY PATT-----SLVNV-------VPKLSSTGRDLLQN----LLKCNP-VQRISAEEALQHPYFADFCPP------------- -------------------------------------------------------------------------------- --------------------------------------------------------- >Takifugu_rubripes(Fugu)CDK6(scaffold_37:_1410884-1431485) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MDTDS---ANT-----------------RYEAVAE- ----------------------------------IGEGAYGKVYKARDLKNE---------------GRFVALKKVRVQT E---EEGMPLSTIREVAVLRQLEAFEHPNVVRLFDVCTVS-RTDRE------------TRLTLVFEHVDQDLTTYLEKA- PDPGVPPETIK------------------------------------------------------------DMMYQLLQG LDFLHSHRVVHRDLKPQNILVTS-GGQIKLADF--GLARIYSFQMALTSV------------------------------ ---------------VVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRR--------------------------- ----------------------PLFRGNSD------VDQLGKIFD----------VVGVPSAEDWPQEVALPQSAFTPRP PKPIE----NFVPD----------MDEQGQALLM-----QFLAFNPSRRISAFAALSHPYFQSVDSHSRSVYAAQPIPSN KPTMEERTA----------------------------------------------------------------------- --------------------------------------------------------- >Takifugu_rubripes(Fugu)CDK15(scaffold_110:_912235-917209) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------QLEESNT---PQPHWFHTLQVRRHRGRRGR--------- --------------------------------------------SNSDPLRENNCQDPFSW-KPALQFGAAHSYVSLEK- ----------------------------------LGEGAYASVYKGIS----------------RINGQLVALKVIRMKT E----EGIPFTAIREA-S--LLKRLKHANIVILHDIIHTS------------------ESLTFVFEYVQTDLAQYMSQH- PG-GLHSHNIR------------------------------------------------------------IFLFQLVRA LSYIHSRRILHRDLKPQNLLISY-LGELKLADF--GLARSKSIPSHTFSS------------------------------ --------------EVVTLWYRPPDVLLGSTDYSTALDIWGAGCIFIEMLQ----------------------------- --------------------GAPAFPGEAA-----ELEQLQTIWEV----------LGMPSEDSWPGISQLPNYKPAEWF VHSEQ----KPFKT---VWKRLNQLPNRTEDLAQK-----MLKMVPGERISAHDALQHPYFSILPPPIMHLRDTVSIFKV PGVYMETEVRDIFNP--GRRVKR---------------MLLPASKFW--------------------------------- --------------------------------------------------------- >Takifugu_rubripes(Fugu)CDK17(scaffold_2:_3724644-3739947) -------------------------------------------------------------------------------- ----------------------LEKMKR------------FKRRLSQTLRGSHT----------------IDES------ ------LSELAEQMTIEE-NGLKDS---EPIVR-NGRPPSV------HSVHSFLHQYTGSFKKPPLR-----RPQSVIGG GLG---SLMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPT------GVCLRNRGNRRISAE----------- -------------------DLNKRLSLPADIRIPDGYLEKLQLSS--PPFDQPLSRRSRRASLSEIGFGKLETYIKLDK- ----------------------------------LGEGTYATVYKGRSK----------------LTDNLVALKEIRLEH E----EGAPCTAIRE---VSLLKDLKHANIVTLHDIVHTD------------------KSLTLVFEYLDKDLKQYMDDC- GN-ILSMQNVK------------------------------------------------------------IFLFQILRG LAYCHRRKVLHRDLKPQNLLIND-RGELKLADF--GLARAKSVPTKTYSN------------------------------ --------------EVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFYEMAA----------------------------- --------------------GRPLFPGSTV------EDELHLIFR----------LLGTPTEDNWPGISSIDEFKSQKFP KYKPQ----PLINH-------APRLDNDGIDLLMS----FLK-YESKKRISADEAMRQAYFRSLGPRVHALPENISIFTL KEVQLQRDP--GYRNASYSESA----------------VQS-RRWISYLSG----------------------------- --------------------------------------------------------- >Gorilla_gorilla_(Gorilla)CDK1(Chromosome_10:_73037381-73053797) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MEDYTKIEK- ----------------------------------IGEGTYGVVYKGRHK----------------TTGQVVAMKKIRLES EE---EGVPSTAIRE---ISLLKELRHPNIVSLQDVLMQD------------------SRLYLIFEFLSMDLKKYLDSIP PGQYMDSSLVK------------------------------------------------------------SYLYQILQG IVFCHSRRVLHRDLKPQNLLIDD-KGTIKLADF--GLARAFGIPIRVYTH------------------------------ --------------EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL------------------------------- ------------------ATKKPLFHGDSE------IDQLFRIFR----------ALGTPNNEVWPEVESLQDYKNTFPK WKPGS--LASHVKN----------LDENGLDLLSK-----MLIYDPAKRISGKMALNHPYFNDLD------NQIKKM--- -------------------------------------------------------------------------------- --------------------------------------------------------- >Gorilla_gorilla_(Gorilla)CDK2(Chromosome_12:_54045895-54051967) -------------------------------------------------------------------------------- ----------------------------