>Homo sapiens GLI1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFNSMTPPPISS------------YGEPCCLRPLPSQGAP------------SVG-TEGLSGPPFCHQANLMSGPHS----------------YGPARETN---SCTEGPLFSS---PRSAVKLTKKRALSISP-LSDASLDLQTVIRTSPSSLVAFIN---SRCTSPG--GSYGHLSIG-TMSPSLGFPAQMNHQKGPS---------------------------------------------PSFGVQPCGPHDS-------ARGGMIPH-PQSRG-------PFPTCQLKSE------LDMLVGKCREEPLEGDMSSPNSTGIQDP-----------------LLGMLDGREDLEREE-KREPE-SVYETDCRWDGCSQEFDSQEQLVH------------------------------------HINSEHIHGERKE---FVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGD-GPLPRAPSISTVEP----------------KRE---REGGPIREESRLTVPEGAMKPQPSPGAQSS---CSSDHSPAGSAANTDSGVEMTGNAGGSTEDLS-----------------SLDEGPCIAGTG---------------------LSTLRRLENLRLDQLHQLR----PIGTRG---------LKLPSLSHTGTTVSRRVG--PPVS-----------------------LERRSSSSSSIS-SAYTVSRRSSLASPFP-----------------------------------PGSPPEN-----------------------------------------GASSLPGLMPAQHYLLRARYASARGGGTSPTAA--SSLDRIG--------------GLPMPPWRSR---------------------AEYPG-----YNPNAGVTRRASDPAQ--AADRPAPAR-VQRFKSLG-CVHTPPTVAGGG--------------QNFDPYLPTSVYSPQPPSITENAAMDARGLQEE-----------------PEVGTSMVG----------------SGLNPYMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPP-------------TNYGPNPCPQQASYPD-PTQETWGEFPSHSGLYPG---------PKALGGTYSQCP----------------------------RLEHYG---------------QVQVKPEQGCPVGSDSTGLAPCLNAHPS--------EGPPHP-QPLFSHYPQPSPPQYLQSGPYTQPPP---------DYLPSEPRPC---LDFDSPT-HSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQ---------------------------EPSYQSPKFLGGSQVSPSRAKAPVN--------------------------------TYGPGFG--------PNLPNHKSG----------SYPTPSPCH-------------------------ENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDN-----TQLDFVAILD--EPQGLSP--------PPSHDQRGSSGHTPPP--------SGPPNMAVG------NMSV----LLRSLPGETEFLNSSA------ >Mus musculus GLI1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFNPMTPPQVNS------------YSEPCCLRPLHSQGVP------------SMG-TEGLSGLPFCHQANFMSGSQG----------------YGAARETS---SCTEGSLFPPPPPPRSSVKLTKKRALSISP-LSDASLDLQTVIRTSPSSLVAFIN---SRCTSPG--GSYGHLSIG-TMSPSLGFPPQMSHQKGTS---------------------------------------------PPYGVQPCVPHDS-------TRGSMMLH-PQARG-------PRATCQLKSE------LDMMVGKCPEDPLEGDMSSPNSTGIQDH-----------------LLGMLDGREDLEREE-KPEPE-SVYETDCRWDGCSQEFDSQEQLVH------------------------------------HINSEHIHGERKE---FVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGD-GPLPRAQPLSTVEP----------------KRE---REGGSGREESRLTVPESAM-PQQSPGAQSS---CSSDHSPAGSAANTDSGVEMAGNAGGSTEDLS-----------------SLDEGPCVSATG---------------------LSTLRRLENLRLDQLHQLR----PIGSRG---------LKLPSLTHAGAPVSRRLG--PPVS-----------------------LDRRSSSSSSMS-SAYTVSRRSSLASPFP-----------------------------------PGTPPEN-----------------------------------------GASSLPGLTPAQHYMLRARYASARGSGTPPTAA--HSLDRMG--------------GLSVPPWRSR---------------------TEYPG-----YNPNAGVTRRASDPAR--AADHPAPAR-VQRFKSLG-CVHTPPSVATG---------------RNFDPHHPTSVYSPQPPSITENVAMDTRGLQEE-----------------PEVGTSVMG----------------NGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPP-------------TNYGPGHCAQQVSYPD-PTPENWGEFPSHAGVYPS---------NKAPGAAYSQCP----------------------------RLEHYG---------------QVQVKPEQGCPVGSDSTGLAPCLNAHPS--------EGSPGP-QPLFSHHPQLPQPQYPQSGPYPQPPH---------GYLSTEPRLG---LNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQ---------------------------ELPYQSPKFLGGSQVSQSPAKTPAAAAA----------------------------A-YGSGFA--------PASANHKSG----------SYPAPSPCH-------------------------ETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDN-----TQLDFVAILD--EAQGLSP--------PLSHEQGDSSKNTPSP--------SGPPNMAVG------NMSV----LLGSLPGETQFLNSSA------ >Rattus norvegicus GLI1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFNPMTSPQVNS------------YGEPCCLRPLPSQGVP------------SMG-TEGLSGLPFCHQANFMSGSQG----------------YGSARETS---SCTEGSLFPP---PRSSVKLTKKRALSISP-LSDASLDLQTVIRTSPSSLVAFIN---SRCTSPG--GSYGHLSIG-TMSPSLGFPPQMSHQKGTS---------------------------------------------PPYGVQPCVPHDS-------TQGSMMLH-PQSRG-------PRATCQLKSE------LDIMVGKCPEEPLEGDMSSPNSTSTQDH-----------------LLGMLDGREDLEREE-KPEPE-SVYETDCRWDGCSQEFDSQEQLVH------------------------------------HINSEHIHGERKE---FVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGD-GPLPRAQPLSTVEP----------------KRE---REGGSGREESRLTVPEGTM-PQQSPGAQSS---CSSDHSPAGSAANTDSGVEMAGNAGGSTEDLS-----------------SLDEGPCVAATG---------------------LSTLRRLENLRLDQLHQLR----PIGSRG---------LKLPSLTHAGAPVSRRLG--PPVS-----------------------LDRRSSSSSSIS-SAYTVSRRSSLASPFP-----------------------------------PGSPPEN-----------------------------------------GASSLPGLTPAQHYMLRARYASARGSGTPPTAA--HSLDRIG--------------GLPAPPWRSR---------------------AEYPG-----YNPNAGVTRRASDPAR--AADHPAPAR-VQRFKSLG-CVHTPPSVATG---------------RNFDPHLPTSVYSPQPPSITENVAMDTRGLQGE-----------------LEVGTSMMG----------------NDLNPYMDFSSADTLGYGGPEGTAAESYGSKGPGSLPLGPGPP-------------TNYGPGHCAQQVSYPD-PTPETWGEFPSHAGVYPG---------TKALGTAYNQCP----------------------------RLEHYG---------------QVQVKPEQGCPVGSDSTGLAPCLNAHPS--------EGSPDP-QPLFSHHSQLPPPQYLQSGPYPQPPH---------DCLSLESRPG---LNFNPSS-HSTGQLKAQLLCNYVQSQQELLWEGRSRGGIPNQ---------------------------ELPYQSPKFLGGSQVSQSPTKVPAAAAA----------------------------ATFGSGFAS-------PALANHKSV----------SYPAPSPCH-------------------------ETFTMGVNRPPHRPAAPPRLLPPLPPCYGPLKVGDANPSCGHPEVGRLGAGPALYPPPEGQVCNPLDSLDLDN-----TQLDFVAILD--EAQGLSP--------PPSHEQGDSSKNTPPP--------SGPPNMAVG------NMSV----LLGSLPGETQFLNSSA------ >Tetraodon nigroviridis GLI1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYNPMTSAIAHGAGTGIGLCTDQYMRPPQALPPHSMMGHR------------GMPPPEGGNSTPYCNQSNMMPSHHN----------------FCQAQGNSDQIGSGDGSRFST---PRSMLKLSKKRALSISP-LSDASVDLQTVIRTSPNSLVAFVN---SRGNANGA-SSYGHLSVG-AMSPSLGYTSNISCQSRQQ---------------------------------------------GSLYGGGGVTPLG-HTPGPCQGSRLPPHNPRLHA-------PPKHGHLKTEPGLSSVMDGMNVKSLEERSEGDVASPSSTGTQDP-----------------LLGLLDGRDDLDKEDGKPEQE-AIYETNCHWESCNKEFDTQDQLVH------------------------------------HINNEHIHGEKKE---FVCHWQDCSREQRPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDTGPRPPGSAMTPGGQ----------------SSELLLEKEEARRDDCKLMAPETSLKSQPSPGGQSS---CSSERSPLGSANNNDSGVEMNLNAAGSLEDLT-----------------ALEDGVGGGGGGGGEP-------GNVGGTMAMSAQALKRLENLKIDKLKQICRPSPPARCAG---------SKLPAIPGTGDNMGMCVP--PPLLSNRRVMELSSHELGGSASVGCS-NDRRGSGTSSLS-SAYTVSRRSSMVSPYLSSRRSSEVSQMGGTA-----GGGCHSFGS-EIVADPLSPETNRRGAPCP--------------------------------GGGLPGLSNLTPAQQYNLKAKYAAATG-GPPPTPL--PNMEQMGATTARRGGYLSEYQGQPLPPFLTQGGPRRHSAN------------TEYGTGVIYPHQAPGNNTRRASDP------------------------------------------------------------------------------------------------------------------------------LSPGHDSLRCPDQAYMHGRYQNPGGDVSSKAG-NSTGQARPFQSEGMSNSLLQQTEYSMSTCQLSPSAPHYPSIGQGGDAGGRWSDNHSHIPTPAHELQSQQGLQYTDA-----------------------------QHTHFNSQPGLYNSPGG--THKLVIKPEQQFHVGMGGRDACQSAKLQQQ-RMLLQQAQGYPQPAGAVMMRNSSSSNCGFQAQNQTTFASG---------GSVSLGCAGK--ALSDGQRSETPMMQVKEMMVRNYVQSQQALMWEQQQEQQQQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTGDSKSVPLSPYAESGPIANALENLDLDN-----TRIDFTSIIEDAESSSFGPINNTLEGQPGPSSQASSRLTTPQNSVSLS-AESGLSNMAVG------DMTS----MLTSLAGENKFLNTLS------ >Gasterosteus aculeatus GLI1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPVDMQPHQGLYHYETSPSHPSRG------------------------------------------LVPSDQSPYT-DVSSLRAPLLNGHPQDCRAMYNPMTPSMAHGSGQGIGNCMDQYMRPPQAPPPHSMMGHR------------GMPPTDGGNSTAYCNQNNMMSSHHN----------------FCQFQSSSDQIGSGDGSRFST---PRSILKLSKKRALSISP-LSDASVDLQTVIRTSPNSLVAFVN---SRCNPNGA-SSYGHLSVS-AMSPSLGYSSNINCQSRQQ---------------------------------------------VSMYGGGGGTPLGGHSTGPCQASRLPPHNPRLHA-------PPKHGHLKTEPGLGGVMDGMNVKSLEERSEGDVASPSSTGTQDP-----------------LLGLLDGRDDLDKEDGKPEPE-AIYETNCHWESCNKEFDTQDQLVH------------------------------------HINNEHIHGEKKE---FVCHWQECSREQRPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDTGPRPPGSAMTPGGQ----------------SSELLLEKEETRREDCKLLAPETTLKSQPSPGGQSS---CSSERSPLGSANNNDSGVEMNLNAAGSLEDLT-----------------ALEDGVAG--GG--EP-------VGVG-TMGMSSQALKRLENLKIDKLKQIRRPTPPGRCSN---------NRLPALPGPGENMGMCAP--SPLLSNRRVMELSNHELGGGAPIGCSSNDRRGSGTSSLS-SAYTVSRRSSMVSPHLSSRRSSEVSQMGGTG-----GGGCHHLSAEKSVGDPLSPETNRRGAPCP--------------------------------GGGLPGLPNLTPAQQYSLKAKYAAATG-GPPPTPL--PNMEQPG-TPARRG-VLSEYQGQPLPPFLQKGGPRRHSAN------------TEYGTGVIYPHQAPGNHSRRASDPVR--SVADPQALP--KRFNSLNNVAMMGRRNALHR---------------GSDTSLARHLYSPRPPSITENVMMEAMGMEPHLAPIDARDRSM----MMPPGERSFMGYQQQHQSLGGVGGPLGNQLSPSHDSLSCPDQVYMQGPYQNQGGEVTSRAGGNPMGQVRPIHSEGISNALLQQAEYSMSTCQLSPSGPHYPSIGQGGDAGGPWSDSHG---------QNQRGLQYSDPSLQPQ-----------------------QTQAHFNNQTGLYSSPDG--THKLTIKPEQQFHPGMGGGNACQSAKLQQQQRMLVQQPQGYPQQTGQVLMGNSNNPSCDFQGQNQNSFPAA---------GGLSLGCAGT--ALADGQRSETPMMQVKEMMVRNYVQSQQALMWEQQQEQQQQSGIKPPP-----------LSDNMDMSGQTAIMQHSPQHQ--NQTLYSSQPYPSYPNQNLAMSPPGHSRGPGSVTPKDQQLAGLQVSCYGQEMVVPRPPQGRKPLSRQNSL-SQVGVGYLGSPPHLSPVHSASSPRRVVRLPPVQHPQHQQ---NEMFSPSNNNMYYSGQISMDMDKHMDPQIGTCLNQPHTMRSNLDPTGGTKTSPMTPYPESGPISNALEHLDLDN-----ARIDFTSIIDDAESSSFSPINNPLHGLPGSSSQASSRLTTPQT--------SGLSNMAVG------DMTS----MLTSLAGENKYLNTLS------ >Danio rerio GLI1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPVDMQPHQGLYHYDNTSNQPSRG------------------------------------------LAPSVRSPYSSEASSVCVALSGGQSVNSREMYN---PSMAPG------ACMEPYMRAPHAPPPHSMMGHR------------GMPPPEGMSGAPYCNQN-MMTSHHN----------------LPHNQHTSELMASGDASCFST---PRSMLKLSKKRALSISP-LSDASVDLQTVIRTSPNSLVAFVN---SRCGPNNP-SSYGHLSVG-TMSPSLGFSSSINY-SRPQ---------------------------------------------GNIYSHPVPSCIG-------APARLPPHNPRLHT-------PAKHTHLKTEPVLGSVMDSINIKGLEDHSEGDVASPSSTGTQDP-----------------LLGLLEGRDDLDKEE-KPEPE-AIYETNCHWESCSKEFDTQEQLVH------------------------------------HINNEHIHGEKKE---FVCHWKDCSREQRPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDTGPRPPG--LTTAGQ----------------SSELLIEKEERNREDCKLLAPDNTLKSQPSPGGQSS---CSSERSPLGSANNNDSGVEMNLNAAGSLEDLT-----------------TQEDSGNAGVSESSAT-------ISSG-GMCMSVQALKRLENLKIDKLKQIRRPTPPGRNAG---------NKLPALSATGEMMSMCAP--SPLLSNRRVMELSAPDMGGVTGMSCPPNDRRGSGTSSLS-SAYTVSRRSSMVSPYLSSRRSSDVSHCQSVM-----GG--------EVPGDPLSPQNSQRAGLCQN-------------------------------SGGLPGLPSLTPAQQYSLKAKYAAATG-GPPPTPL--PNMDQAG-TPARHVGFLRECQGQPLPPFLQQGGTRRHSAN------------AEYGTGVIYPHQAPGNNTRRASDPVR--SAADPQGLPKVQRFNSLSNVSLMSRRNALQQ--------------CGSDAALSRHMYSPRPPSITENVMMEAMGMDGN---TEGRQQGN----MIPGGDRSYMGYQHNP--------HQASQLSPGQESLGCIDQVYQSQMQGQYQREESCSTG--VMGQAD------IANNLLQQAEYGMSTCQLSPSGPHYPSQ---GDGSGPWGQTNQ---------LHSPGMQYQGAG----------------------------MQGQHYTQQGIYDPTSNPNLQRVTVKPEQ-FHPSMGGSSSCQNTKALHQNRHNAN-MQTYPLQ-GQGIMNRSSSASCDFHHSQMGTQPNQ---------GGSFQSGTGINLALAESRRSQTPMHQMKEMMVRNYVQSQQALLWEQQQEQSVSEK-----------------PDGMDMG-QTQMMQHSPQHQQANQNLYPGNTYQGYPNQNLMSPQQ--NRVPGSVKEQMQS------SCYGPDMIP-RPPQVRKSLSRQNSLSQQAGGAYLGSPPHLSPVHSTASPRRGVRLPPVQQQQQQQQQHSENFNNNNNPMYYSGQMHMHHDLEKTPE-GPCLAQQHLTSS--DPTTKPTS---ISYPDPAPMSNALEHLDLEN-----AQIDFTSIIDDQEPSSYSPINAPI-GHNQCSSQTSSRLTTPQNSITLP---SGLSNMAIG------DMSS----MLTSLAGENKYLNTLS------ >Takifugu rubripes GLI1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPVDMQPHQGLYHYDSSPGQPSRG------------------------------------------LVPSDQSPYS-DVSSLRAPFLNGLPQDCRTMYNPMASSMTHGSGPGIGLCTDQYMRPPQALPPHSMMGHR------------GMPPPEGGNSTPYCTQSNMMPSHHN----------------FCQAQGNSDLIGSGDGSRFST---PRSILKLSKKRALSISP-LSDASVDLQTVIRTSPNSLVAFVN---SRGNANGA-SSYGHLSVG-AMSPSLGYTGNISCQSRQQ---------------------------------------------GSIYGGGGVTPLGGHTPGPCQGSRLPPHNPRLHA-------PPKHGHLKTEPGLSGVMDGMNVKSLEERSEGDVASPSSTGTQDP-----------------LLGLLDGRDELDKEDGKTEQE-AIYETNCHWESCSKEFDTQDQLVH------------------------------------HINNEHIHGEKKE---FVCHWQECSREQRPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDMGPRPPGSAMTPGGQ----------------SSELLLEKEETRRDDCKLMAPETSLKSQPSPGGQSS---CSSERSPLGSANNNDSGVEMNLNAAGSLEDLT-----------------ALEDGVGGGGGG--ES-------ASAGGTMGMSAQALKRLENLKIDKLKQICRPSPPARCGS---------NKLPALPGTGENLGMCVP--SPLLSNRRVMELSSHELGGSASAGCS-NDRRGSGTSSLS-SAYTVSRRSSMVSPYLSSRRSSEVSQMGGTA-----GGGCHVFGSEQIVADPLSPETNRRGAPCP--------------------------------GAGLPGLSNLTPAQQYNLKAKYAAATG-GPPPTPL--PNMEQIG-TTARRGGVLSEYQGQPLPPFLTQGGPRRHSAN------------TEYGTGVIYPHQAPGNNTRRASDPVR--SAADPQALP--KRFNSLNNVALMGRRNALQH--------------RGSDTSLSRHLYSPRPPSITENVMMEAMSMDTHLTPLDSRDHSM----MMPPGERSFIGYQQQHQAHGGGA-SLSNQLSPSHDSLSCPDQAYMHGCYQNPGGDVTSKDG-NSIGQARPHQSEGMTNTLLQQTEYSMSTCQLSPSAPHYPSISQSGNAGGRWGNNHSQIQSSPHELQSQQGMQYTDASLQS-------------------------QQTHFNNQPGLYNGPGG--THKLVIKPEQQFHPVMGGRDACQSAKLQQQ-RMLLQQTQGYPQQTGQVMMRNSSNSSCGFPVQNQNTFASG---------GSVSLGCAGK--ALSDGQRSETPMMQVKEMMVRSYVQSQQALMWEQRQEQQQQSGIKPA------------LSDNVDLAAQTAMIQHSPQHQ--NQNLYPNQPYPSYPNQNMIMSPP--SRGPSSVPPKDQQLTGLQGSCYGQEMAP-RPPQGRKPLSRQNSL-SQVGGVYIGSSPHLSPVHSSS-PRRGVRLPPVQHPQHPQ---NEMFSPSNNNNNLYCSGQVNLDKIIDSQNGPCLNQQHGMGSGLDPTSDPKSAPLGPYPESGPISNALENLDLDN-----TRIDFTSIIDDAESSSFGPVNSTLQGQPGSSPQASSHLTTPQTSMSLT-AGSGLSNMAVG------DMTS----MLTSLAGENKYLNTLS------ >GLI2 Homo sapiens --------------------------------------------------------------------------------------------------------------METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGV--------------------------------------PQHLLPPFHAPLPIDMRHQEGRYHYEPHSVHGVHG------------------------------------------PPALSGSPVISDISLIRLSPHPAGP--GESPFNAPHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAP--GTTPSDYYHQMTLVAGHPAPYGDLLMQ----SGGAASAPHLHDYLN-PVDVSRFSS---PRVTPRLSRKRALSISP-LSDASLDLQRMIRTSPNSLVAYINN--SRSSSAAS-GSYGHLSAG-ALSPAFTFPHPINPVAY---QQILSQQRGLG----------------------------SAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSS-SSNCLSDTN--QNKQSSESAVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALP-LSQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVH------------------------------------HINNEHIHGEKKE---FVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHLRTPLLKENGDSE---AGTEPGG---PESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGAQSS---CSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLT-----------------ALDDTPPGADT-SALA-APSAGGLQLRKHMT----TMHRFEQLKKEKLKSLKDSCSWAGPTP-----HTRNTKLPPLPGSGSILENFSGSGGGGPAGLLPNPRLSELSASEVTMLSQLQERRDSSTSTVS-SAYTVSRRSSGISPYFSSRRSSEASP---------LGAGRPHNASSADSYDPISTDASRRSS----EASQCSGG---------------------------SGLLNLTPAQQYSLRAKYAAATG-GPPPTPL--PGLERMSLRTRLALLDAPERTLPAGCPRP---LGPRRGSDGPTYGHGH------AGAAPAFPHEAPGGGARRASDPVR-RP--DALSLPRVQRFHSTHNVNPGPLPPCADR-----RGLRLQSHPSTDGGLARGA-YSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIK----------------AHASGALDEGTG--QVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKNNMPVQWNEVSSGTVDALASQ---------VKPPPFP-QGNLA---------------------------VVQQKPAFGQYPGYSPQGLQASPGGLDSTQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTISGALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPTGRH------------------------------------------RGVRAVQQQ-LAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAPDHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSS-TVDSQLLEA-----PQIDFDAIMDDG-DHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVG------DMSS----MLTSLAEESKFLNMMT------ >Mus musculus GLI2 --------------------------------------------------------------------------------------------------------------METSAPAPALEKKEAKSGLLEDSSFPDPGKKACPLAVAAA----VAAHGV--------------------------------------PQQLLPAFHAPLPIDMRHQEGRYHYDPHSVHSVHG------------------------------------------PPTLSGSPVISDISLIRLSPHPAGP--GESPFSAHHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAP--GTNPSDYYHQMTLMASHPTPYGDLLMQ----SGGAASAPHLHDYLN-PVDASRFSS---PRVTPRLSRKRALSISP-LSDASLDLQRMIRTSPNSLVAYINN--SRSSSAAS-GSYGHLSAG-ALSPAFTFPHPINPVAY---QQILSQQRGLG----------------------------SAFGHTPPLIQPSPTFLAQQPMTLTSISTMPTQLSSSSSNCLNDAN--QNKQNSESAVSSTVNPITIHKRSKVKTEAEGLRPASPLGLTQ------------------EQLADLKEDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVH------------------------------------HINNEHIHGEKKE---FVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHVRAPLLKENGDNE---ASAEPGGRGPEESVEASSTSHTVEDCLHIKAIKTESSGLCQSSPGAQSS---CSSEPSPLGSAPNNDSGMEMPGTGPGSLGDLT-----------------ALADTCPGADT-SALA-APSTGGLQLRKHMS----TVHRFEQLKREKLKSLKDSCSWAGPAP-----HTRNTKLPPLPVNGSVLENFNNTGGGGPAGLLPSQRLPEL--TEVTMLSQLQERRDSSTSTMS-SAYTVSRRSSGISPYFSSRRSSEASP---------LGGLRPHNASSADSYDPISTDASRRSS----EASQCSGGG--------------------------PGLLNLTPAQQYNLRAKYAAATG-GPPPTPL--PGLDRVSLRTRLALLDAPERALPGACPHP---LGPRRGSDGPTYSHGHG--HGYAGAAPAFPHEGPNSSTRRASDPVR-RP--DPLILPRVQRFHSTHNMNPGSLPPCADR-----RGLHVQSHPSVDSNLTRNA-YSPRPPSINENVVMEAVAAGVDGPGLECDLGLVEDELVLPDDVVQYIK----------------AHTGGTLDDGIR--QGYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMGPSAPGLGGCQLSYSPSSNLNKSNMPVQWNEVSSGTVDALPTQ---------VKPPPFP-HSNLA---------------------------VVQQKPAFGQYPGYNPQSVQSSSGGLDSTQPHLQLR-GAPS--ASRGSYTQQPRQPAAGSQCLGMSAAMSPQASYSQAHPQLSPNIVSGSLNQFSPSCSNMAAKPSHLGLPQQMEVVPNATIMNGHQREHGVPNSSLAAVSQPHPVLSYPQQ----------DSYQQGSNLLSSHQPGFMESQQ------NAGFGLMQPRPPLEPNTASRH------------------------------------------RGVRSGQQQ--LYARTTGQAMVTS-ANQETAEAMPKGPAGTMVSLAPQPS-QDTGRAQDQNTLYYYGQIHMYEQNGG------CPAVQPQPPQPQACSDSIQPEPLPSPGVNQVSS-TVDSQLLEP-----PQIDFDAIMDDG-DHSSLFSGALSPTLLHNLSQNSSRLTTPRNSLTLPSIPAGISNMAVG------DMSS----MLTSLAEESKFLNMMT------ >Rattus norvegicus GLI2 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTLTSIT-VPTQLGSNSSNCISDAN--QNKQNSESAVSSTVNPITIHKRSKVKTEAEGLRPASPLGLTQ------------------EQLADLKEDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVH------------------------------------HINNEHIHGEKKE---FVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHLRAPLLKENGDNE---AGAEPGGRGPEESVEASSTSHTAEDCLHIKAIKTESSGLCQSSPGAQSS---CSSEPSPLGSVPNNDSGVEMPGTGPGSLGDLT-----------------ALDDTSPGADT-SALA-VPSTGGLQLRKHMT----TMHRFEQLKREKLKSLKDSCSWAGPAP-----HTRNTKLPPLPVNGSVLENFNNTGGCGPAGLLPNQRLPEL--TEVTMLSQLQERRDSSTSTMS-SAYTVSRRSSGISPYFSSRRSSEASP---------LGGIRPHNASSADSYDPISTDASRRSS----EASQCSGGG--------------------------PGLLNLTPAQQYSLRAKYAAATG-GPPPTPL--PGLDRVSLRTRLALLDAPERALPGACPQP---LGPRRGSDGPTYNHGH----GYVGAAPALPHEGPNGSTRRASDPVR-RP--DPLVLPRVQRFHSIHNMNPGPLPPCTDR-----RGLHLQSHPSVDGSLTRHA-YSPRPPSINENVVMEAVAAGVEGAGLESDLGLVEDDLVLPDDVVQYIK----------------AHTGGALDDSTR--QVYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMSPSAPGLGGCQLSYSPSSSLNKSNMPVQWNEVSSGTVDALPTQ---------VKPPSFP-QSN-----------------------------LVQQKPAFAHYPGYSPQALQSGSGGLDSTQPHLQLR-GAPS--ASRGSYTQQPRLPATGSQCLGVTAAMSPQANYSQTHHQLSPNVVSGSLNQFAPSCSNMAAKPSHLGLPQQMEVVPNATIISGHQRELGIASSSLAAVSQPHPVLGYPQQ----------DGYQQVSGLPSSHQPSFMESQQ------NTGFGLMQPRPPLEPNTASRH------------------------------------------RGVRSGQQQQQLYARTAGQAVVTS-ANQETAEAMPKGTAGTVVSLTPQPS-QDTGRSQDQNTLYYYGQIHMYEQNGG------CPAMQPQPPQPQGCSDNIQPEPLPSPGVNQVSS-TVDSQLLEP-----PQIDFDAIMDDG-DHSSLFSGALSPSLLHNLSQNSSRLTTPRNSLTLPSIPVGISNMAVG------DMSS----MLTSLAEENKFLNMMT------ >Tetraodon nigroviridis GLI2 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAA------------------------------------------P---------------RLDAHPAP------------------------------------RPRGFS----------------------------------------------------------------------TSVSRFSS---PRLTPRLSRKRALSISP-LSDASIDLQTMIRTSPNSLVAYINN--SRSSSAAS-SSYGHLSVGPGIR---------NPVG--------------------------------------------------------------------------------------------------------------------------------------------------------GILDLSEDLDKDECKQEPE-AVYETNCHWEGCTKEYETQEQLVH------------------------------------HINNDHIHGEKKE---FVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCT-----------------GCSKAYSRLENLKTHLRSHTGEKPYLCEHEGCNKAFSNASDRAKHQNRTH----SNEVGPQLAAMPCSVHPNSELESPSFQKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRSDMAPRPQPPKGNGVNE---ANSRHGAKGVEGKLEANSTSGGMENCLQIKSIKTENSMMYQSSPGGHSS---CSSEPSPLGSTNNNDSGVEMAMHSGGSFADLS-----------------AQDESPMVDSTVPAGG-QQAGVGLHLRKAVGHSGTVTIKLENIKKERLKTVSTS-DWVSSAAQPLQGQRSSVKLPPIPAVGSLLENSTM--MSNSSVCYPGPRKGDLSSCEVTLLNQLNERRDSTTSTIS-SAYTVSRRSSGISPGYSSRRSSEASQ---------FGANRHNNVSSADSYDPISTDLSRRSS----EASQCG----------------------VGGGATL---LSLTPAQHYRLKAKYAAATG-GAPPTPL--PNMDRMSLRTRMALYSDSQEASLHQFHQPPTGAVPRRCSD-----MGY-------GTRSMMPHEVPSSLPRRASDPVR-RPPLDPLSLPRVQRYNSMNNMNPLNVTTAERY-----QSLLAQGYTRSDGNLQRYP-FAPRPPSISENVAMENMAMDGMA-GGDQNGE---DDMVLPDDMVQYLR----------------SQNTDPSANNSCQVDYHSNHQNQGFQAGIAPPPAYYSQRRMAMVDASMPHSGQ--DSQQPFSAPPANTNKNNMPVQWNEVSSGTVDSTSKL---------SKQQHHPLRGNLA---------------------------VVQQRHNFSSFQGPSQ--------ALSSNQQVVPMSQNVSTQAYANHSNQRLTHASQPQQQQQRQYIPANFGQHMS-PQQGFGQEFIP-----------NSISGSTSMRPAQNGMASSEPQSYRARTQTDGYCRVNPMDVQQNYNVLTQQHQS-----------------------------------IHSGARGSLQPRPPAEPRSSLR----------------------------------------------QHLGSNMMPPNRVPKSSALSPCDGNETSEASPKRCSGLAA--------QNSNSEN---SVFYTGQIHMFEP-------SFDAPMSPCASEPPANSTTAAS--MASPGVNLVSSSTTDSSTGASGGAQHPQIDFDTMLDDG-DHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSLPLASVPAGIGNMAIG------DMNS----MLTALAEESKFLNMMS------ >Gasterosteus aculeatus GLI2 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLFPTFHTPIPIDMRHHEGRYHYEPHPLHAMHG------------------------------------------PPGLTGSPVISDISLIRLSPHVAPGT-GESPFSPPHHYVSPHMEHYLRSVHGSPTLSMISAARGLSPAEVTHEHLKERALFNLPPPPPGANPTDYYHLMASAS-QRSPYGDLLIQ----STAHLPEYISP------MDVSRFSS---PRLTPRLSRKRALSISP-LSDASIDLQTMIRTSPNSLVAYINN--SRSSSAAS-SSYGHLSVG-GISPSFSFPHPINPVAY---QQLLSHQRSL-----------------------------NAFGHTPPLIHPSPSSFSARQHPLAASPMTTSHNTSSSEANQCVN--TCKNASGDPAVSSTVNPL-STKRSKVKTEAEGPLPISPSSQDHC-----------------GGILDLSEDLDKDECKQEPE-AIYVTDCHWEGCSKEYDTQDQLVH------------------------------------HINNDHIHGEKKE---FVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRSDAPPRPQPPRGDGENG---ANS----KIADGRVEANSTSRGVEDCLQVKSIKTENSMTYQSSPGGHSS---CSSEPSPLSSANNNDSGVEMALHSGGSFGDLS-----------------ALDDCPMVDSTVSAGG-QQAGVGLQLRKAVGHVGTVTIKLENIKKERLKTVRDSCPWVNSAPQPPQGQRSSMKLPPIPAVGSLLESSNM--ISNLSGSYPGQRIGDLSSSEITLLNQLNERRDSTTSTMS-SAYTMSRRSSGISPCYSSRRSSEASQ---------FGTNRHNNISSADSYDPISTDLSRRSS----EASHCGGGG-------------------VGGGGLP-SVLSLTPAQHYRLKAKYAAAIG-GAPPTPL--PNMDRMSLRTRMALYGDPQEGTLHPFHQPDFGTVPRRCSD-----IGY-------GTRSMMPHEVPTSLPRRASDPVR-RPTLDPLSFPRVQRYNSMNSMNPVNGPPAERH-----QALTMQGYTRSDGSLQRYP-FAPRPPSISENVAMENMAVDGMIIGGEQGGE---DDMVLPDDVVQYLR----------------SQNSGPSGHNLGQGDFHSNNLTKGYQTGMTSSASFYAQRRMAMADANMTQSGQDMQSQQPFSAPPGNVNKNNMPVQWNEVSSGTVDTTKKL---------SKQHQHPLRGNLA---------------------------VVQPRHNLGSFQGQGQ--------GLGSNQQVVPMSQNMSIQGYANHNSQRMMSIPPQQHQQLRQCNPVNMSEQMS-PQQGFGQEIIP-----------NSISGSTSVRPTRNNMAVTEVHSYRARTQVDGYCHVNQVDQQQNYSVVSQQHN------------------------------------IHNGGRGMLQPRPPIEPKAIAR----------------------------------------------QQTGSSMMQPNRIPKSSDLNPSFGTDTSEASPKRPTGSSA--------HNCNSANPNSAMLYSGQVHMFAPTSV----SFDASMPPSASHAPASNTTAADH-MASPGVNHVSSSTVDSSTNAAAGTEHAQIDFDTLLDDG-DHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSVTLTSVPAGIGNMAIG------DMNS----MLTALAEENKFLNLIS------ >Danio rerio GLI2b ---------------------------------------------------------------------------------------------------------------MEAGVPAPAEKKDCKSSPLEGNVFSEMPKKPSPSSLSRGP------------------------------------------------HHIFPTFHSPIPIDVRHHEGRYHYDPHALHALHG------------------------------------------PPGLAGSPVISDISLIRLSPGAAG-----EAFLPPHSYVSPHVEHYLRSAHSSPTLSMISAARGLSPAEVAHEHLKERGLFGLPPPP-GASPADYYHLMAG---HRNPYGELLMQ----GAGAAAAAAHLPEYFTSVDVSRFPS---PRMTPRLSRKRALSISP-LSDASIDLQTMIRTSPNSLVAYINN--SRSSSAAS-SSYGHLSVG-GISPSFPFPHSINPVAY---QQLLTQQRGL-----------------------------SAFGHTPPLIQPSPTFSSRHPLSLSTLPTPTTNDTETK------------NSNGESAVSSTVNPL-GNKRSKVKTELGGPRPVSPYSPEHL-----------------SSAQDLKEDMD--DCKQEAE-LVYETNCHWEGCSKEYDTQEQLVH------------------------------------HINNEHIHGEKKE---FVCRWDECSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDLPSRPHPPKENGENE---AGA----KMAEEKIEANSTTRGVEDYLQVKSIKTENSMMYQSSPGGQSS---CSSEPSPLGSASLHGGGVEPAGLSGGSVGDLS-----------------ALDDVPIVDSTVSTG-----ILGLHLRKNAG----PAHRLTHLKQEKLKSVRDSCSWANTAP-----PAPCTKLPPIN-TGSLLDG-----LCDPGLSISSPRLGDLCPGETTVLSQLVERRDSLASTVS-SAYTFSRRSSGISPCYSSRRSSQTSQ---------PGG-RHNNISSADSYDPISTDLSRRSS----EASLYG------------------------------GIFSLTPAQHYRLKAKYAAATG-GAPPTPL--PNIDCKTLLG------DSHEIPIHPP------LVPRRCSD-----TGY-------ANRSVLPHEVTANITRRASDPVR-R-----IAAERHSLYNSVNPYPTLHPLASSR-----------HFYSTSESNVNRQQ-YPPRAPSISENVMMETLPDDMESCNGVEDG------LMMADDAVQCIT----------------TQN-ADSPQHTG-----VAHRNQSFGS----PQHCHLQRRLALVEGNMNAVARQTASSQQTFPGSANATKIPMPVQWNEVSSGTVDSSRSQ---------TKQGSG--RGN------------------------------LQQKQNLSSFLN------------VNSNQQVGLMSHNLALS----------PVQRSVEFNSLRINQRQANAEFLHGYLQGSASNDIS-----------LGLLNPSGKSLTVQPGGVQNNRVCAQAQSHATFPNNQGNYSQMSSNQQGYIVAS-----------------------------------QNVNGNLLLQPRPPTEPKPYST----------------------------------------------QHSG-----PTTTAAQSNFSP--AYDTSEASPKKS----------------------SSMFYTGQIHMFDS----------SGAMPCPSS------------VGSPETNQVSS-TVDSSGADP-----PQIDFDAMLDDG-DHSSLMSGTLSPALLRSLSQNSSRLTTPRNSVTLPPVAAGISNMAIG------DMSS----MLTALAEESKFLNMMS------ >Danio rerio GLI2a ---------------------------------------------------------------------------------------------------------------METTSPTSTEKKELKPSVLDGSSFTDLPKKPSPT-TASRA------------------------------------------------PHLFSTFHTPIPIDMRHHEGRYHYEPHPLHPMHG------------------------------------------PHGLAGSPVISDISLIRLSPHAAAT--GESPFNPPHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPAELTHEHLKERSLFGLPPPPPGANPSEYYHLIAS---HRSPYGDLLMQ----TGAAAAHLPDYMSP---VDMSRFPS---PRLTPRVSRKRALSISP-VSDASIDLQTMIRTSPNSLVAYINN--SRSSSAAS-SSYGHLSVG-AISPSFTFPHPITPVAY---HQLLSQQRGL-----------------------------NAFGHTPPLLQPSPALSSRQQTLVAAAALNNTTSSSTSSSTADTSTESSQNAGGDPAVSSTVNPM-IFKRSKVKTEAEGPHPISPGSQ---------------------DHLELREELDKDECKQEPE-AVYETNCHWEGCAKEYDTQDQLVH------------------------------------HISNDHIHGEKKE---FVCRWVECSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDAPPKPHPPKGNGENE---AHTKHVRGRTDGSGEANSTTRGVEDCQHVKTIKTENTVMYQSSPGGQSS---CSSEPSPLGSATNNDSGVEMAMHSGGSLGDLS-----------------ALDDTPVVDSTGSPG--TSAGVGLQLRKNR----AGLLQLEHIKKEKLKTVRDSCSWANAPP-----QVRNTKLPPIPSIDSLLDAPNM--GTQMSVP-PTQHLGDLSSYEMTMLNQLHERRDSSTSTMS-SAY-ISRRSSGISPCYSSRRSSEASQ---------FGV-RNNNVSSADSYDPISTDLSRRSS----EASQCG-----------------------GTGGLP-SLLNLTPAQHYSLKAKYAAATG-GAPPTPL--PNMDRMSLKTRMAMYNDSQDSSAHLHHAQG-VVNSRRCSD-----TGY-------GAPGMMPHEVPANLPRRASDPVR-RTTLDPLSLPRVQRFNSISNMN-LSRLPAYDR-----RAFNMQNNTWSDGSLHRHP-FSQRPPSISENILMENMATD----GGDQQG----DDLVLPDDMVQYLR----------------SQN-GNSNHDSG-ISVNGGHALEFHGNMTSQQQQFYGQRRMGMAGINGSHVEP----VPEQIADPQGMNKNNMPVQWNEVSSGSADAVSRV---------PKQQQQQLRGNLT---------------------------VVQQKQNFGSYQG------------FGSNQQIVPMSQNLAS-----------LQQAYPQRNIQRMNTVQQFRQSISNPCQNIGEQVNR-----------QDLSYNSNQRLICNSMGPPNGRMVQNQELQNYRSNLMHMNNINQQNYVPLTQTA-----------------------------------FQNAGRGLIQPRPPSEPKPLNR----------------------------------------------QHSGSGMVQPNGCSLSN-------VNSSEASPKRP-GEVG--------QHSNGNG---TMYYSGEIHMLDN-GI----DYGSPMSPCTNQAPVAS---VST-MASPGVNQVTS-TVDSTQSLD----HTQIDFDAMLDDG-DHSSLMSGTLSPGLLQSISQNSSRLTTPRNSVTLASVPAGIGNMAIG------DMSS----MLTALAEESKFLNMMA------ >Takifugu rubripes GLI2 ---------------------------------------------------------------------------------------------------------------MENSATTAAEKKECKSSGLDGSPSEIPKKLSPTT-LSRGA------------------------------------------------HHLFPTFHTPIPIDVRHHEGRYHYEPHPLHPMHG------------------------------------------PPGLTGSPVISDISLIRLSPHAAPGS-GESPFSPPHPYMSPHMEHYLRSVHSSPTLSMISAARGLSPAEVSHEHLKERTLFSLPPPPPGANPTEYYHLMA--S-QRSPYGDLLMQ----SGEMGPHLFSKPFIGPLSAVSRFSS---PRLTPRLSRKRALSISP-LSDASIDLQTMIRTSPNSLVAYINN--SRSSSAAS-SSYGHLSVGPGISPSFGFPPHINPVAY---QQLLSQQRGL-----------------------------SAFGHTPPLIQPSPSSFSTRQHPLSASAMSAALNNSNSDTRGSFSS-VCQSASGDPAVSSTVNPL-TTKRSKVKTEAEGLLPISPSSQDHG-----------------GGILDLSEDLDKDECKQEPE-AVYETNCHWEGCTKEYETQDQLVH------------------------------------HINNDHIHGEKKE---FVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCSKAYSRLENLKTHLRSHTGEKPYLCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKQRSDVPPRPQPPKGNGVNE---ANSRHGAKGVEGKIEANSTSGGMEDCLQIKSIKTENSMTYQSSPGGHSS---CSSEPSPLGSTNNNDSGVEMAMHSGGSFGDLS-----------------AQDECPMVDSTVPAGG-QQAVMGLHLRKAVGHPGTVTIKLENIKKERLKTVSTS-DWVNSAAQPLQGQRSSVKLPPIPAVGSLLENSTL--MSNSSISYPGQRRGDLSSCEVTLLNQLNERRDSTTSTIS-SAYTISRRSSGISPGYSSRRSSEASQ---------FGANRHNNISSADSYDPISTDLSRRSS----EASQCGGGG-------------------LGGGATLPSLLSLTPAQHYRLKAKYAAATG-GAPPTPL--PNMDRMSLRTRMALYSDSQEASLNQFHQPSPGTVPRRCSD-----MGY-------GTRSMMPHEVPGNLPRRASDPVR-RPTLDPLSLSRFQRYNSMNNMNPLNVSTAERY-----QSLVTQGYTRSDGNLQRYP-FAPRPPSISENVAMENMVMDGMT-GADQNGE---DDLVLPDDMVQYLR----------------SQNTGPSANNLGQVDFHSNHQNHGFQTGMAPPPSYYSQRRMAMVDATMTHSAQ--DSQQPFSAPPENMNKNNMPVQWNEVSSGTVDSTAKL---------SKPQHHPLRGNLA---------------------------VVQQRHNFSSFQGQGQ--------ALSSNHQVVPMSQNVS-----------------------MQYVPVNFGEHMS-PQQGFGQEFIP-----------NSISGSTSMRPAQNVVASSELQ--RGRTQTDG---------------------------------------------------------------GSLQPRPPAEPKSNMR----------------------------------------------QHPGSNMMHPNRVAKSSALSPCDGTETSEASPKRRSGPAA--------HNSSSEN---SVFYTGQIHMFEP-------SFDAPMSPCASEPPANSTSAAN--MASPGVNLVSSSTIDSSTGVSGGPQHPQIDFDTMLDDG-DHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSLPLASVPAGIGNMAIG------DMNS----MLTALAEESKFLNMMS------ >Homo sapiens GLI3 ------------------------------------------MEAQSHSSTTTEKKKVENS-IVKCSTRTDVSEKAVASSTTSNEDESPGQTYHRERRNAITMQPQNVQGLS-KVSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTVFAMDPRNGYMEPHY-------------------------------HPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHM------------------------------------------TSALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMD-YIRSLHSSPSLSMISATRGLSPTD---------------APHAGVSPAEYYHQMALLTGQRSPYA-DIIP----SAATAGTGAIHMEYLHAMDSTRFSS---PRLSARPSRKRTLSISP-LSDHSFDLQTMIRTSPNSLVTILNN--SRSSSSAS-GSYGHLSAS-AISPALSFTYSSAPVSLHMHQQILSRQQSLG----------------------------SAFGHSPPLIHPAPTFPTQRPIPGIP-TVLNPVQVSSGP-----SESSQNKPTSESAVSSTGDPM-HNKRSKIKPDEDLPSPGARGQQ-----------------EQPEGTTLVKEEGDKDESKQEPE-VIYETNCHWEGCAREFDTQEQLVH------------------------------------HINNDHIHGEKKE---FVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHSQSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSS---CSSQQSPISNYSN--SGLELPLTDGGSIGDLS-----------------AIDETPIMDSTISTAT---TALALQARRNPAG----TKWMEHVKLERLKQVNGMFPRLN--------PILPPKAPAVSPLIGNGTQSNN-TCSLGGPMTLLPGRSDLSGVDVTMLNMLN-RRDSSASTISSAYLS-SRRSSGISPCFSSRRSSEASQAEGRP----------QNVSVADSYDPISTDASRRSS----EASQ---------------------------SDGLPSLLSLTPAQQYRLKAKYAAATG-GPPPTPL--PNMERMSLKTRLALLGDALEPG-VALP---PVHAPRRCSDGGA---------HGYGRRHLQPHDAPGHGVRRASDPVR--TGSEGLALPRVPRFSSLSSCNPPAMATSA-----EKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESLTMDADAN----LNDED----FLPDDVVQYLN----------------SQNQAG--YEQHFPSALPDDSKVPHGPGDFDAPGLPDSHAG---QQFHA-------LEQP----CPEGSKTDLPIQWNEVSSGSADLSSSK---------LKCGPRPAVPQTRAFGFCNGMVVHPQNPLRS--GPAGGYQTLGENSNPYGGPEHLMLHNSPGSGTSGNAFHEQPCKAPQYGNCLNRQPVAPGALDGACGAGIQASKLKSTP-MQGSGGQLNFGLPVAP-----------NESAGSMVNGMQNQDPVGQGYLAHQLLGDSMQHPGAGRPGQQMLGQISATSHIN------------------------------IYQGPESCLPGAHGMGSQPSSLAVVRGY------------------------------------------QPCASFGGSRRQAMPRDSLALQSGQLSDTSQTCRVNGIKMEMKGQPHPLCSN----LQNYSGQFYDQTVGFSQQDTK------AGSFSISDASCLLQGTSAKNSELLSPGANQVTS-TVDSLDSHDLEG--VQIDFDAIIDDG-DHSSLMSGALSPSIIQNLSHSSSRLTTPRASLPFP-AVHEHHQHGYRGHEFFADLPSGRKQIPCSYAIGFRKKRLQPTEINRS >Mus musculus GLI3 ------------------------------------------MEAQAHSSTATERKKAENS-IGKCPTRTDVSEKAVASSTTSNEDESPGQIYHRERRNAITMQPQSVQGLN-KISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTVFAMDPRNGYMEPHY-------------------------------HPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHV------------------------------------------PSALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMD-YIRSLHCSPSLSMISAARGLSPTD---------------APHAGVSPAEYYHQMALLTGQRSPYA-DILP----SAATAGAGAIHMEYLHAMDSTRFPS---PRLSARPSRKRTLSISP-LSDHSFDLQTMIRTSPNSLVTILNN--SRSSSSAS-GSYGHLSAS-AISPALSFTYPSAPVSLHMHQQILSRQQSLG----------------------------SAFGHSPPLIHPAPTFPTQRPIPGIP-TVLNPVQVSSGP-----SESSQSKPTSESAVSSTGGPM-HNKRSKIKPDEDLPSPGSRGQQ-----------------EQPEGTTLVKEEADKDESKQEPE-VIYETNCHWEGCTREFDTQDQLVH------------------------------------HINNDHIHGEKKE---FVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHSQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSS---CSSQQSPISNYSN--SGLELPLTDGGSVADLS-----------------AIDETPIMDSTISTAT---TALALQARRNPAG----TKWMEHIKLERLKQVNGMFPRLN--------PILPSKAPAVSPLIGNGTQSNN-NYSSGGPGTLLPSRSDLSGVDFTVLNTLN-RRDSNTSTISSAYLS-SRRSSGISPCFSSRRSSEASQAEGRP----------QNVSVADSYDPISTDASRRSS----EASQ---------------------------GDGLPSLLSLTPVQQYALKAKYAAPTG-GPPPTPL--PHMERLSLKTKMALLGEGRDSG-VTLP---PVHPPRRCSDGGG---------HTYRGRHLMPHDALANSVRRDSDPVR--TVSENMSLARVQRFSSLNSFNPPNLPPSV-----EKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALEALTMDADAN----LNDED----LLPDDVVQYLN----------------SQNQTG--YGQQLQSGISEDSKVAHEPEDLDLAGLPDSHVG---QEYPA-------LEQP----CSEGSKTDLPIQWNEVSSGTSDLSSSK---------LKCGQQRPRQQPRGFGLYNNMVVHPHNLWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGDGLGTNGNTFHEQPFKTQQYGSQLNRQPLTSSALDHACGTGIQGSKLKGNS-LQENGGLLDFSLSVAP-----------NELAGNTVNGMQTQDQMGQGYIAHQLLSGSMQHQGPSRPGQQVLGQVGATSHIN------------------------------IYQGTESCLPGTQDNSSQPSSMAAIRGY------------------------------------------QPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSSRVNSIKMEAQGQSQQLCST----VQNYSGQFYDQTMGFSQQDRK------AGSFSLSDANCLLQGTCTENSELLSPGANQVTS-TVDSFESHDLEG--VQIDFDAIIDDG-DHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPIPIHGHHQHGYRGYEFFADLPCRRKQVPCSYAVGGRQGGPQTQRLK-- >Rattus norvegicus GLI3 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HINNDHIHGEKKE---FVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHSQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSS---CSSQQSPISNYSN--SGLELPLTDGGSIADLS-----------------AIDETPIMDSTISTAT---TALALQGRRNPAG----TKWMEHIKLERLKQVNGMFPRLN--------PILPSKAPAVSPLIGNGTQSNN-NYSSGGPGTLLPSRSDLSGVDFTVLNTLN-RRDSNTSTISSAYLS-SRRSSGISPCFSSRRSSEASQAEGRP----------QNVSVADSYDPISTDASRRSS----EASQ---------------------------GDGLPSLLSLTPVQQYRLKAKYAAATG-GPPPTPL--PHMEKLSLKTRMALLGEGRDSG-VTLP---PVHPPRRCSDGGG---------HTYSRRHLLPHDALANSARRASDPVR--TVSENMSLPRVQRFSSLNSFNPPNLPPSV-----EKRSLVLQNYTRQESTHPRYFQASPCPPSITENVALEALTMDADAS----LNDED----FLPDDVVQYLN----------------SQNQTG--YGQQLQSSISEDGKVAREPEDLDLPGLPDSHVG---QQYPA-------LEQP----CSEGSKTDLPIQWNEVSSGSSDLSSSK---------LKCGQRPTVQQARGFGLYSNMVVHPQNLWKVGTGPAGGSQTLGENGSSYSDPEHFAVHSGDGLGPSGDTFHEQAYKTQQYGSQLSRQPLTSSVLDSACGAGIQGSKLKGNS-LQENGGLLDFGLSMAP-----------NELADNIVNGIQTQEQMGQGYIAPQLLSGSMQHQGPSRPGQQVLGQVGATSHIN------------------------------IYQGTESCLPGTQDKISQPSSMAVIRGY------------------------------------------QPCASYGGSRRQAMPRGSLTLQQGQLSDVSQTSRVNSIKMEAHGQSHQLCSS----MQNYSGQFYDQTMGFSQQDRK------AGSFSLSEANCLLQENGSENSELLSPGVNQVTS-TVDSFESHDLEG--VQIDFDAIIDDG-DHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPSLSMSTTNMAIG------DMSS----LLTSLAEESKFLAVMQ------ >Gasterosteus aculeatus GLI3 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGLAGSPAFSDISLIRISPQRNPSVGAESPFHPPHPYINPYMD-YIRSLHSSPSISVLSATRGLSPADVISSSFLQKRLL-YSAPHTGLTTAEYYHQMALLAGHRSPYATDLLPSVASTAGATSATALHMEYLQAMENSRFSS---PRLPSRPSRKRPLPISP-LSDHSFDLQTRIRHSPNSLVTMLNN--SRSSSSTS-GSYGHLSAG-AISPALSFAYPSTPVALHMHQQLLGRQPGMVG---------------------------SAFGHSPPLIHPSPAYATQRPVPGIPPSGLSASERSALS-----SDSAQTKPTSESAVSSTGDPM-HHKRSKMKPEEELPSPGAVSVQSLGRRGGNCFCFCLIKIDHPDGMTLVKEEGDKDESKQEPE-VVYETNCHWENCCREFDTQEQLVQ------------------------------------HINNDHIHGEKKE---FVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIQGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGD----------------------LPLGGYTDQREYNHATSKQDECLQVKSIKTEKPMTSQPSPGGQST---CSSDQSPVSHYPC--SGVQLAVSAGRSLGEG----------------HCVGERAPIMDSTVSTAT--AAMLTLQARRSVGRP---LRWMEHMKMERLKQVNGALPRLGPLS-----PTPPPKGSTLPNILGKENSN---ITTDLCLNPAVRNKLSP-DSIFPVWLLERSGVKTDVVWVLISSYCVKLNSSGISPCFSSRRSSQASQSEGTAA-AAHHHRRLHNLSSSDSYDPISTDASRRSS----EAS-----------------------------HGSRGMLTLTPAQHYHLKAKYAAATG-GPPPTPL--PNMERMSLKTRMAMMDEGGSN--QSLP---PLVRPHCCGDGANGYANGYAGHAGHRRRVLYPGEGPLNGNRRASDPVR-TQAGDMGSLPPVQRFNSLNNLHPLP-PLSH-HSTPEARSFSLQSYTRSEGNLQRGLQHSPYTPSIAEHAALEALAMEDEAG--LLLGDED----MLPDDLVQYLH----------------SQAQVDGGSYMHIEEQIASSQRDASHPPMEEMGQIQAAGLDMGHAGSHG-------LLQQQQQTAERTSPSKLPIQWNEVSSGSADRSPQR---------EQIHRAQCGRWPA--------------------------AEHG--PVPFGRFGNMVVQQQVPLDFQNSCVQANQSQGACF-----------VNPAVK-------LETPPNSCMEMRG----FGRPNFA-----------QIIDGPLQQGFKHPPPGGPPKQSHFQQNHS--QMGSN----LILSRSSVDILPS------------------------------VSQGAAAHHNRQIHVPRPPDGYRNSARI------------------------------------------QQYLNAETSGESQAGLNKQQQLQRSGDHCSLAHQVSGLKLEASDHGYLEQGFGDCLSYAPLDCKASPFPVLEDQCLL------NSMVESAGQVVGGGGGGGNSAALLSPGTDQVTS-TMEGAVPGILDDG-VGLDFGAMLEDGYDQGSLVSGVLSPSIFQGLSRTSSRLTTPRASAAFHSVAPGLNNMAIG------DMSS----LLTTLAEESKFLAILQ------ >Tetraodon nigroviridis GLI3 ------------------------------------------------------------------------------------EDDSSGTPFHRERRNAISSHAPTPGGLDRSISEEPSTSTEERPSLLKKELHGSLAHLGDHALPYRGTLFAMDPRNGYLDSHYLRATLRCRQPVSAGGFLVCLLPKWHPHRYVSAAPQFFPTFHPPVPIDDRHTQGRYIYEPSPVPPLHVFWYPASHRERIRPLSAPRDEGHFFILLSNCPKRIRWNFGGRRPPALAGSPAFSDISLIRISPQRNPSVGAESPFHPPHPYISPYMD-YIRSLHSSPSISVLSATRGLSPAD---------------APHTGLTTAEYYHQMALLAGHRSPYAADLLPSLAATAGASGAAASHVEYLHAMESSRFSS---PRLPSRPSRKRPLPISP-LSEPSFDLQTMIRNSPNSLVNILNN--SRSSSSTS-GSYGHLSAG-AISPALSFAYPPTPVALHVHQQLMGRQPSIVG---------------------------SAFGHSPPLIHPSPAFTTQRPVPGIPASGISASERSAIS-----SDSSQTKPTSESAVSSTGDPM-HHKRSKMKPEEELPSPGAVSIQ-----------------DHPDGMTLVKEEGDKDENKQEPE-VVYETNCHWENCCREFDTQEQLVQVRHKRQVQRRLVGDVGGAALSLFSDEELALHAEAAAHINNDHIHGEKKE---FVCRWEDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDYPRPPPQPREPGSNGQGRSPGQLPLGGYTDQREYTHSTSKPEECLQVKSIKTEKPMTSQPSPGGQST---CSSDQSPVSTHPY--GRVQLAVSAGRSPGEGLEESEEKEENEEADEECEEGEQAPIMDSTVSTAS--TAMLALQARRSVGRS---LRWMEHVKMERLKQVNEALPRLGPLS-----PTPPPKVSTLPTILGKGSCLGR-QWGVTAPQPPAHGELG--STELTVLNLLRDRRDSSGSATSSAYLSSSRRSSGISPCFSSRRSSQASQNEATMA-AVYHRR-LHNLSSTDSYDPISTDASRRSS----EASHCGG---GGGGMLSAGGCGGAFGLGVGGGGGSRGMLSLTPAQHYHLKAKYAAATG-GPPPTPL--PNMER--------MMGD-------------ALVRPHRCADGSPGSVNGHTGHSGYRRRVLYPGEGSANRNRRASDPVR-SQAPDACSLPPVQRFSSLNNLHPLP-PLSH-HSIPENCSLSLQNSARSEGNMQRILQHSAYNPSIAEHAALEALAMEEDGGAGLLLGDED----MLPDDLVQYLH----------------SQVQSDSCAFMNVEEQLASSQRDPSYPSMEELEQIQSSGLDMSYSGSHG-------LQQ---QIAERRSPSSLPIQWNEVSSGSADRS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Takifugu rubripes GLI3 ----------------------------------------METQSQASSAAEKKKKVETIAATKGLVARNDISEKAVASSTTSNEDDSSGTPFHRERRNAISSHAPTASGLDRSISEEPSTSTDDRPSLLKKEQHSSLPHLADHALPYRGTLFAMDPRNGYLDSHY-------------------------------AAPQFFPTFHPPVPIDDRHTQGRYIYDPSPVPPLHV------------------------------------------PPALAGSPAFSDISLIRISPQRNPSVGAESPFHPPHPYISPYMD-YIRSLHSSPSISVLSATRGLSPAD---------------APHAGLTTAEYYHQMALLAGHRSPYATDLLPSLAATASASGAVAPHVEYLHAMESSRFSS---PRLPSRPSRKRPLPISP-LSEHSFDLQTMIRNSPNSLVNILNN--SRSSSSTS-GSYGHLSAG-AISPALSFAYPPTPVALHVHQQLIGRQPSIVG---------------------------SAFGHSPPLIHPSPAFATQRPVPGIPPPGISASERSAIS-----SDSSQNKPTSESAVSSTGDPM-HHKRSKLKPEEELPSPGAVSIQ-----------------DHPDGMTLVKEEGDKDESKQEPE-VVYETNCHWENCCREFDTQEQLVQ------------------------------------HINNDHIHGEKKE---FVCRWEDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDYPRPPPQPREPGTNGQGRSPGQLPLGGYTDQREYNHSTSKQEECLQVKSIKTEKPMTSQPSPGGQST---CSSDQSPVSTYPY--SRVQL---------------------------------APIMDSTVSTAS--TAMLTLQARRGVGRP---LRWMEHVKMERLKQVNEALPRLGPLS-----PTPPPKVATLPNILGKGSCLGR-QWGVTAPQPPINGELG--STELTVLNLLRDRRDSSGSAASSAYLSSSRRSSGISPCFSSRRSSQASQNEATTA-AAHHRR-LHNLSSTDSYDPISTDASRRSS----EASHCGGGAGGGGGGPLSGGCGGVFGLGVGGGGGSRGMLSLTPAQHYHLKAKYAAATG-GPPPTPL--PSMER--------VMDDGGSN--QTLP---PLVRPHRCSESSWGNTGGYVGHSGSRRRVLYPGEGALNRNRRASDPVR-TQAPDACGLPPVQRFSSLNNLHPLP-PLAH-HSIPENCSLSLQSSTRSEGNMQRFLQHSTYNPSIAEHAALEALAMEEDGGSGFLLGDED----MLPDDLVQYLH----------------SQVQSDSLSLLNIEDQLASSQRDTSYPSMEEFEQIQSSGLDMSYPGSHS-------LQH---QIAEQKSPSSLPIQWNEVSSGSADKSPHR---------KQNQQTAYGRWTG--------------------------SGNGCASAPFGRFQNMVVQQQVPLEFQNNCPNASQPQGACS-----------VNPAVK-------LETLPNSCMELRGTRGTFGRSTFP-----------QGLDGPLPQVFKQQPANGAPRQSHSQLKHHSTTPSQD----GADPGSSLNNLSG------------------------------LSHGAALSLHRQVHVPHPPNSYRTFARA------------------------------------------QQGHNSSNMLTN----TKQQLMRRNGDHCSLAHQVSGLKLEAPDQGYSESGYGQSLSYGEGDCKASSFLALKDQCLL------GSITEPLGQSEGING--TAPVALLSPGADQVTS-TVDSLGP-PLDQG-TSLDFGAILEDGFDQGSLG--------------TSSRLTTPRASAAFHSVAPGLNNMAIG------DMSS----LLTTLAEESKFLAIMQ------ >Danio rerio GLI3 ------------------------------------------MEPQFQTSSSTEKRMENVVGTNSAPTRTDISEKAVASSTTSNEDDSSGSPYHLERRNTISAQTDVVN-TSGKVSEEPSTSTDERLPLVKKELQSFLHRLADHTLPYRGTLFAMDLRSGYLDPHY-------------------------------TAPQFFRAFHHPVPIDDRHTQGRYIYEPSPVPSLHM------------------------------------------PPALAASPTFSDISLIRISPHRNPSMGTDSPFNPSHPYINPYMD-YIRSLHSSPSLSMVSAARGLSPAD---------------THHTGLTTAEYYHQMALLVGHRSPYA-DLIPSVGSTTGP-ASSALHMEYLQAMESSRFPS---PRLINRPSRKRPIPNSPSLSDPSFDLQAMIRTSPNSLVTILNN--SRSSSSNS-GSYGHLSAG-TISPALSFAYPPTPVALQMHQQLISRQPGIVG---------------------------SAFGHSPPLMHSALAFSTQRPVPAIQTSSLAPTERSIVS-----NDS-QSKPTSESAVSSTGDPM-NHKRSKLKPEEEPPSPRAVSMQ-----------------EQMNGMTLVKEEGDKEEGKQEPE-VVYETNCHWDGCCREFDTQEQLVH------------------------------------HINNDHIHGEKKE---FVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGETYPRPP-------------PQPREPGATTDQKEYTHATSKQDECLQVKSIKTEKPMTSQSSPGSQSS---CSSDQSINGPHVS--QGVQLTVNSIGLAGEVAMLEDMENEEEDEENREGEKEDAPIMDSTVSTATSSAATIVLQTHRSVGRP---LRWMEHVKMERLRQVNGAVPRLGFLP-----PTPPRKGQAMPALTGKGQCLGR-MTSVRVPPCPEP----S-NTELTILSLLHERRDSSGSNTSSAYLSSSRRSSGISPCFSSRCSSQASLSEYSP------HRHIHNLSATDSYDPISTDASRRSS----EASQYDG-------GSSSAVVFGGSGVFKGSGMGSRGDLNLTPAQHYSLKAKYAAATG-GPPPTPL--PSMGHINLKTHFALKEDRKDTGQLTLP---PLVRSRRCSDGAH---NSHDSQAVYQRKGTYFGGGPGKNDRRASDPTHHKQNLSSYGLPQVRHFSSLNNMTSSPNPASYGYSNREDHSLNLQNSTCHVDSFQSGL-HSPCPPSIMEQSALENIFMNQDG---LLLRVNE----NIQSDFMQYLH----------------SQDQ---------ESIIIQDNHRPIFNPADDQNFLSPQ------QQQEG-------VEQ------EDTRIDLMPIQSNEVSSASADVTIPR---------QPFQR--CGRWS---------------------------DQSGSVSNAFGRFGNMVVQQQ-PIDFIDQHSALQHMGGISYGCRNSEQHLQVAKPAQEKSRMKTGIKTESSSTFQLESKHSNFGRPDFS-----------HIFSAPIHQKCSQHTVVS---QSYPQQNQITNQDSSN----LFLQRPGN--------------------------------------------CSLLLAYRPQPAVNTSYST------------------------------------------RQDINSHNVQSC----HPQSLNNRLGTSCSLSNQVSVVKLDQVNHLQINSCS---TIQQQKPVFIDKCFDPEESKLS------HAIVQSCLMESLMAEKERTSKVLLSSGVGQVTS-KVE----RSPAEK-VGLGICSIGGDSYDQGSVVS--------------SSRLSNSHDSFAFHSVDPGTNNMAIS------DMNS----LLTTLAEESKFLAIIQ------ >Branchiostoma floridae GLIA -------------------------------------------------------------------------MASTSPGVTKEPERRPAESSESKSDKSRHHGEAKSAETSIKKEAASSSEYAHPRLEPSRPGFPHPPLISEHRSTYPYPSFGLDPRNGYVDPHFMS---------------------------------PVMPFHQPIPVDARTNEGRYTFDPHNVYHVPIHS-----------------------------------------PPFGGSPVLSDVSMLRLTPHRPHSDPTSPLHGPHPAFRLNP---FFSPYHGTPPLSALSQARGLSPHDG-------------------MTAAEYYHMAAMSQQRMYS-----------DMPPLSGGSGSIAIDLPTDGSRFST---PRTAARHGRKRALSISP-LSGECLDLNSMIRTSPNSLVAFINGGSRSGSSAST-GSYGHLSASAMRTESGAESKPGTQSSANMPFSAPMPMFPYPTS-------------------PAMQQFHNRLMRQKSPFHFGMPHASPFAAPLPAGMAMLAAQGAMPPSSSAATHTETKASLGD----AFTMEPSESKRSKVKYEGSQGSPDDVPSTTFP-------------------AESRSETSMAEGTNEDAEPPVYETNCHWDGCSKEFDTQDQLVH------------------------------------HINNDHIHGEKKE---FVCRWSECTREQKPFKAQYMLVVHMRRHTGEKPHKCTEIMPQISLRTLPVLPFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHS--NA--------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHQTKKHKTLGPTPRPRDPPSEKRD--------------QDSVSSPPDSNGVHSSTTNPAASQGSPGQKPTEGHKPTGQTCDAQQSVYGSSPHHDSGVEMNANSGSLPDLS------------------TLDDQVISDSSISSTVPTSRASGVMVAARPGLVPRAPRIGNKPSNQRRRMRLSSGTPGPTSPP----RSDSVQLPPIEKTGSRGPSAQGSHSSVEAANRRTNELRASDLSQTSRTSSLGSLGSRKDSASTVSSYYSSRRSSEASPFPESIFSSRRSSQASPFPGINRRTSNGSLYSPNDSYDPISLGSSRKSSDAS-------------------------------SLSMNVNELGINIEQQQMLRARFIQATG--RPPTAV--CGNDSRPESRRGDRKEKENVEEPNPRRQSDLGHYNRLKGTP-------------------LPKEVKDGPHRRSSAPQK---NDVVTNLPDVPRDHSFNKHTPLPPVTPQPP----------PQIKKAFSPSKVKQAFSPKSASTSMQGVAEEFPMDLIENEPD---------VIIPDEMVQFLN-------------SQTGDDPREMVPNFEQVGTTPTFVEDIPPMQVNPIQGDGFSNMGSPQQAFSPNRQPMPPIQQQQ-AFNQSQQVLSPSRQSYKMSQPMGSQPLSP---------MEVNMAALDHSPN---------------------------PPTYNASQMSPAQQFSPASYDPNLNSPSCRVQQNYSQMGMQSPVPNYASPTRQAQNMAPKLPNMQPQMLSPQQRQQSQQQQLQQQMQ------------SQQQQMQQMQKLQQMQKMQQMQKMQQMQKMQQMQKMQQMQKMQQVQKMQQMQQQQ----------------------------------QQQQQAQMQNMQVQRQMQNMQKQ------------------------------------------SQLQQQMQNLQQQQRLQQQNLQQNYNMQQMQNLQSQMQLSPN-------------VQQQMQNLQLSPSGQQYLPEG-------AQQMQYQANVQFYNLQNQSGRPLENPTQVNVVHSTIEPHHSPQRPDGAADINLENVAMPTQNPMGFPAG--NAGYTQDQSTNFVGGVNMSTPMVPPETPGSASNMVIN------DMSS----LMASLAEENRYLNMMG------ >Branchiostoma floridae GLIB -------------------------------------------------------------------------MASTSPGVTKEPERRPAESSESKSDKSRHHGEAKSAETSIKKEAASSSEYAHPRLEPSRPGFPHPPLISEHRSTYPYPSFGLDPRNGYVDPHFMS---------------------------------PVMPFHQPIPVDARTNEGRYTFDPHNVYHVPIHS-----------------------------------------PPFGGSPVLSDVSMLRLTPHRPHSDPTSPLHGPHPAFRLNP---FFSPYHGTPPLSALSQARGLSPHDG-------------------MTAAEYYHMAAMSQQRMYS-----------DMPPLSGGSGSIAIDLPTDGSRFST---PRTAARHGRKRALSISP-LSGECLDLNSMIRTSPNSLVAFINGGSRSGSSAST-GSYGHLSASAMRTESGAESKPGTQSSANMPFSAPMPMFPYPTS-------------------PAMQQFHNRLMRQKSPFHFGMPHASPFAAPLPAGMAMLAAQGAMPPSSSAATHTETKAGEPSSSIVSSTMEPSESKRSKVKYEGSQGSPDDVPSTTFP-------------------AESRSETSMAEGTNEDAEPPVYETNCHWDGCSKEFDTQDQLVH------------------------------------HINNDHIHGEKKE---FVCRWSECTREQKPFKAQYMLVVHMRRHTGEKPHKCTEIMPQISLRTLPVLPFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHS--NA--------------------------KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHQTKKHKTLGPTPRPRDPPSEKRD--------------QDSVSSPPDSNGVHSSTTNPAASQGSPGQKPTEGHKPTGQTCDAQQSVYGSSPHHDSGVEMNANSGSLPDLS------------------TLDDQVISDSSISSTVPTSRASGVMVAARPGLVPRAPRIGNKPSNQRRRMRLSSGTPGPTSPP----RSDSIQLPPIEKTGSRGPSAQGSHSSVEAANRRTNELRASDLSQTSRTSSLGSLGSRKDSASTVSSYYSSRRSSEASPFPESIFSSRRSSQASPFPGINRRTSNGSLYSPNDSYDPISLGSSRKSSDAS-------------------------------SLSMNVNELGINIEQQQMLRARFIQATG--RPPTAV--CGNDSRPESRRGDRKEKENVEEPNPRRQSDLGHYNRLKGTP-------------------LPKEVKDGPHRRSSAPQK---NDVVTNLPDVPRDHSFNKHTPLPPVTPQPP----------PQIKKAFSPSKVKQAFSPKSASTSMQGVAEEFPMDLIENEPD---------VIIPDEMVQFLN-------------SQTGDDPREMVPNFEQVRTTPTFVEDIPPMPVNPIQGDGFSNMGSPQQAFSPNRQPMPPIQQQQQAFNQSQQVLSPSRQSYKMSQPMGSQPLSP---------MEVSMAALDHSPN---------------------------PPTYNASQMSPAQQFSPASYDPNLNSPSCRVQQNYSQMGMQSPVPNYASPTRQAQNMAPKLPNMQPQMMSPQQRQQSQQQQLQQQMQSMQ---------SQQQQMQQMQKLQQMQKMQQMQKMQQMQKMQQMQKMQQMQKMQQVQKMQQLQQQQ----------------------------------QQQ--AQMQNMQVQRQMQNMQKQ------------------------------------------SQLQQQMQNLQQQQRLQQQNLQQNYNMQQMQNLQSQMQLSPN-------------VQQQMQNLQLSPSGQQYLPEG-------AQQMQYQANVQFYNMQNQSGRPLENPTQVNVVHSTIEPHHSPQRPDGAADINLENVALPTQNPMGFPAG--NAGYTQDQSTNFVGGVNMSTPMVPPETPGSASNMVIN------DMSS----LMASLAEENRYLNMMG------ >Ciona savignyi GLI METAGKNDIDVLHQKCGKDFSREEKATPQTHLPPDHKIEGSEHHSRRSEAPKPGKQSAFFSSQDENEAREEAVVSSSTSPSDKRTKRSSSPDHNEHLRQQNDELRHQSRHQSVREAATSTTTFEDEFEKQFHGNENLGVTSSDGRPPSCGTPLGKIKEETSSNNRKVMLLGNAHQFTKPSPSNRNMTSSQAGNTNCNGEDRRYPIGNPHTQVDPHSRDGRYPFEPRTMNNAPG---------------------------------------------FSGSPIHSDISLIPMSPQQSAN--PFNYNSSLEFYMGGLSQGGLRSPTMSILSQARNLSPHHSIQELEKLCYPYYNAHQSNMSVNGAQQNSNQSLPGNFSQNINPLAYYQLMQQQQRLLAVAARNDRNLALSLEKQEDFGR-FPSPLCRSRARKRPLSISPCFSDTGLDITAMIRTSPNSLLPFGGLTNSRSSSVASGGSYGHLAAG-GISPTFGYQTPMMTSPQHLHAHLLSR-----------------------------------------QMQSSFAGQLMPGFPTNQGAFDKPNSRFDPN-------ISTRNYLPHVGASAASNDMCNPHRDNKNFSKHSVDPQSPNVQFNN---------------NNNNSNSIPGISPGGHGANEENDVVYDTNCSWVNCSLEFDTQEQLVH------------------------------------HINNDHIHGDKKE---FVCRWIGCARDQRPFKAQYMLVVHMRRHTGEKPHRCTF---------------EGCSKAYSRLENLKTHLRSHTGEKPYVCEYPSCTKAFSNASDRAKHQNRTH----SNE------------------------KPYACKQAGCTKRYTDPSSLRKHVKTVHGPEAHVTKRMKAEREREGKREPNIKQEPGMDKDKRKGDAGGTKRTCHPLSPGSNPPSNDQNPPSNMNPRSNQSSCTSGSD-VSVTPQNSPHMTSQNNDSGVDVNVGANEGDSDGD----------------IVVDENPQPDSTSGGVG-------VQSRHRGTVRASLVPRLVNKKMQNLSIGGNIESYVDIGG------YDDQRKLGMHKAESFTEVSSTTAFPAKQKNATFPRKLPLTPHRQVALLNQDRRDSGTVSDGSRKSSLASQNSRRSSQNTGG-------------------------INVAGSYDPISLDSSRRSS-----------------------------------SNVTSGSSALNPYQLHRLRSRFNENAG-LPPPTPVDREGYTKSQLSRWLKDDTPIPDRGGYLYNPQQRPSLPQMGPPKPPMEDRRRSEPRSSARTPLPPHLGGGVAFRRASDPTRKSPQMDPTRLPNVQRHNSWNSIHPLPGIKPQ-----------------GCAYPGAVPCNPSNQPPMQQVQRQRSISNSSN-----------------------YYG-----------------GESGYHSHGSNMALHQPSYQVNEQVLMENFNNDVINGDVTYNGQVYGKSDHWHQQTTPHPHQTMTPASVGSMPPHQRFPQNGHINQNPFP---------------------------------------------------------------------RSFNNNPNVGPNKGVQDANATRYYGNPHFNPNAQMGGQVHGHPTMRPQKMTQQNVTQQFGNPDFMQLPYN---------APSPYIAQRQSVQNQGRSPNMINSGNVEMHLGHQNRTANQITPRPPVSSTSSNQN--------------------------------------RMRLQRVRQSGSSSVTSYN-----------------------------------------------------------------------------------------------------QAPSVTSQSNGQAGRTNYTPDAQIPDEFLQQEFIDSIPELHPETHRENEPNENQPYVKMAADSTTGP----DLDGITGNFCYQDDDAMSGTNTDVTLPPMSAFSSRMATPMMGKYPPQIPTNQHPASNMAIN------SMSS----MLSTLEEENKYLNLLPQ----- >Strongylocentrotus purpuratus (XP_001195249) -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSVSKQVTEPNNNQVTSSVDLDNHQSKGMDD--PNTVSSTS-HMEGSPSAP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------APGGDHRDDDGAHGGEEDIPVVTDCEWDDCHRKFDTLDQLVQYDN------------------HLFFFLLKFVCNLLQHINNDHIHNERKE---FICHWRDCIREEKPFKAQYMLVVHMRRHTGEKPHKCSF---------------EGCYKAYSRLENLKTHLRSHTGERPYVCEFQGCTKAFSNASDRAKHQNRTH----SNA------------------------KPYACKITGCTKRYTDPSSLRKHVKTVHGPEAHVTKRQRGDKRDPPSGSGGEKEGR-------------------KGDDMDKKSPGDVKPITKAISVSSNSTNNNRTKG---VPQECHTSAHQSVHLSAPVNDYSSSPHN----------------------DSGVEMNATGGSIG----------------------DLTSIDDEKLIQDDQISSNVGDLG------------DGIGHRGRMGRRGGGGGRGSLTVTTAPTIIGRTTSPFMERSIKIKAGMSRPTHKAKTGVHILPQMPPPPPPPLQQQLPPVINN--------------------------------------------------------------------------NNHGIDYKPKARNIEKLIFEERCD--SSQSMT--GNLDNLG---------------------------NRRGSD---------------------HSTVSSYFSGRSSEASP---------FFMGSQFSSRRSSQASSYMSSMSS--------------------RRTSGASQWSGHMGMNSPYDPISIGSSRR----------------------------------------SSEASSLNGPTGLPGLTLAQQRSLQARYEQTIMQQNSGDER------------------------FGMTPSPMPPPGYRRLSGVASMPPHP---------------------------------------------------------------------------PRTPLPNEIPGNEIRR--------------------GSEPISSNQNSHMNRRYSSFN----------------NKQPLPLPENMKNFRPAFHNIHHPPTIHEQDGGSGREQWQNIPQNHYEHGTIPEE--------------------------------------SMDTGGSGGPEEFMFP-------------------------------------------------------------------------------------------------------DEMVQFLDDQCKQEMQWTG------QRQMPAGGGGGDGGRGFNQPHGNNHPGHNQMQG----------------GYNMQPLNSDALDHVQQIVPETMESETENKMPYNSQGASAGYPQQENVVNPTISNMAVT------DMSS----MLTSLAEENRFLSIM------- >Drosophila melanogaster (Ci) -------------------------------------------------------------------------------------------------------------------------MDAYALPTYFPLAYSELQFLASRR-------------------------------------------------------AAAVAAAATVLPGSPCINQHHPTDVSSSVTVPS------------------------------------------IIPTGGTSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHVHNINVTGQPHDFHPAYRIPGYMEQLYSLQRTNSASSFHDPYVNCASAFHLAGLGLGSADFLGSRGLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSP--YSDSFDINSMIRFSPNSLATIMNG--SRGSSAAS-GSYGHISAT--ALNPMSHVH--STRLQQIQAHLLRASAGLLNPMTPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPG-DFIETNCHWRSCRIEFITQDELVK------------------------------------HINNDHIQTNKKA---FVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTH----SNE------------------------KPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSR----------------------HNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLLTYSPDDLAENL-----------------NLDDGWNCDDDVDVAD------------------------LPIVLRAMVNIGNGNASASTIG---------GSVLARQRFRGRLQTKGINSSTIMLCNIPESN---RTFGISELNQRITELKMEPG--------TDAEIKIPKLPN---------------------------TTIGGYTEDPLQNQTSFRNT-----------------------------------VSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQSR--RSSQSS------------QVSSIPTMRPNPSCNSTASFYD------------------PISPGCSRRSSQMSNGANCNSFTSTSGLPVLNKESNKSLNACINKPNIG-----------------VQGVGIYNSSLPPPPSSHLIATNLKRLQRKDSEYHNFTSG-----RFSVPSYMHSLHIKN----------------NKPVGENEFDKAIASNARRQTDPVPNINLDP-----LTNISRFSTTPHSFDINVGKTNNIASSINKDNLRKDLFTVSIKADMAMTSDQHPN---------ERINLDEVEELIL---------------------------PDEMLQYLNLVKDDTNHLEKEHQAVPVGSNVSETIASNHYREQSNIYYTN----KQILTPPSNVDIQPNTTKFTVQDKFAMTAVGGSF-----------SQRELSTLAVPNEHGHAKCESFHHQSQKYMNTDIGSKQQSALPSAHQRQTEKSNY--------------------------------------NQIIDSSMTSLPELN---------------------------------------------------------------VDSIYPRNETENIFKVHGD-----------------------HDNEIQCGIISQSQMSP--------STNLNNDGQFSTVNMQPITTSKLFPPEPQKIVCDTQASN----TSVMHLDTYQRTLEYVQSCQNWMETNNTSTNQIQSLPGMPVNNTLFPDVSSSTHPYHGTNMVIN------DMTT----SLTSLLEENRYLQMMQ------ >Apis mellifera(XP_624136) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSSSTTAIG------------------------------------------TAATGGGGGASSGASGGGGGGSGGGGGGAAGNGTSGGDFLRRSHPLSEHTALHPAYRLN-YMDHLYHQLQASTHS-------PNASLHGLGGLGP-----------------EYLLHAAGPASTLASSEFPFSIDVSASSRLGSPRASAIRA--SRKRALSSSP--YSDRFDIDSMIRFSPNSLASIVNG--SR-SSSAS-GSYGHLSAA--MSPALGMHPGMAPHLQQLQAHLLRSAA----------------AAALLPHAHPLQRPAPPPPPPHPHPHAHGLSPHSQLYPGVPPHSTASATLGPHGG------GLPPKTESAESCRKASESTTRSVTAEADTSSRRTSTKVKREPATTTTN---------ATTTTAPPTHPQGLSPSEDLRDEPG-DFIETNCHWRDCGLEFPTQDDLVK------------------------------------HINNDHIHANKKS---FVCGWEECSREEKPFKAQYMLVVHMRRHTGEKPHKCTF---------------EGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTH----SNE------------------------KPYVCKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGGGGDGGGSDEAGAGGH----------------------SPSRSEDLHPKTPSLSSPSVKSESEANSPPSMMQQQGSPLVGGCNDEVAGVGTLTGDGVALAEEP-----------------WNEE----PDDLDIAD------------------------LPVALRAMVGGMESQQQQQPP-----------PPASRNRLKGRLNAKGMPNLPVSVSSMRGTRGMGPQGNIGDLNRRITDLKMEGGGSARQTSLSDLQLRLQPLSEPRRDSNSTVSTYYGSMK---------STDFGSRRSSQASGVSAVRMG-----------------------------------QTGPGSFYDPISPGTSRRSSQMSTTSGRMNPPNLQ--GPYSTSNLVVQTQNMSLQGIQGIPGDWNGPSGHCTQLSGD------------------RRMSEPTRGHQTQRNSPPVPPRPRSAQLPEHHPNQEVILDEVGEGEMVENKLV-IPDEMMQYLNQVQAGGTQVNCRSPLPICQSPICTNPLHYQRQIQPTCNYNQSHQQTCYPSSQSAQPCTNYQN----------------TSPSPYNQCPSSRPPQSNSQYCPPPTYPLQPNGGQVLSPAAGQVMSPGSHYAPSHISDQPLTSPAAGALAPQHPPQNLPQNSAQLTRNCPQ---------NHMHHGYYPNYNC---------------------------QGQMNANCTGNPNGQVNHHTNSTCAPPNHNTMTQQQCVQMRSAGNCQQLSSHCTQQPVIPNQTTMSHPNTQCGQVANQCTRPIVTPNG-----------QMPNLHSVQQTTVPNQCAQMSPHCSQLNMNNQAKPITNMTNLQGCQQQVQQPTTP--------------------------------------CLQMANCAHPNSGHRPI-------------------------------------------------------------TDNTLSKRTSPQLCSAQQTNC-------------------RMQQQQHTCTHNCQARTNPP-------NHQYNCNCQWGYDQCYHEQTGTAMPEIQCRDISQSQQGSPIKPPQGMRQDSYRRTLEYVQQCRNWSGNAQTHETNVSSST---------HPISLPQPLPSSANMVVN------DMTS----SLSSLLEENRYLQMIQ------ >Caenorhabditis elegans (Tra) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTENDPSKNGLG-----------------------------------------------------------------SATSNFIQS--SVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASSDELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGS-----------------------------------------------------------------------------------------------------TVATSVGQNVRLTINGKRVGRPPGTFKRPQN------------------------NAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVD------------------------------------HVQESHVQSTEQEHHAWRCEWEGCDRNE-TFKALYMLIVHVRRHTGEKPNKCEY---------------PGCGKEYSRLENLKTHRRTHTGEKPYKCEFADCEKAFSNASDRAKHQNRTHSNL----------------------------KPYSCQIPQCTKSYTDPSSLRKHIKAVHGDDEYEKAKKSRPANYSNRRRPDHRLAP----------------------PTGAMSHPYLATPNSGASVVAHSSVHQQNF-----INMALAQHHHNAQRAQQLMAATGNVMPMMD-----------------PASAAAAAQAQAHHQA--------------------QAQMLQTHMMQQAQIQAAAQMQAQVQ----------HQAAMQAHAMQQAQMVLQNNLLGAQSLLSPFSPLLPPSRAPNVMAMLQTPPTPTSVAPMFDIMTSRAPMAPVVSAPTAPAPLVPAP----------------VPASPVFDELREQMREVEP--------------------------------------LQQQQQQEPMDQDLQDIRVDGDSDDEDEEEPR---TPSGALLLPRGGNNGDGGFGGSGSSRASSGSGTMELSAAP-----------------------ISQNGSRASGSGER-----GMRSFLIADILQLAADFQNERLLSDVLD-------------LAIFDTRDVRSLHNIYQVYIRAHKAIPITRRPLDWN-----------------------------------------ETHQLHNLYHDPRFNRAEHQDSPAIRDRDTRFWRTIAEANTMRQRQIEPVPLDDDDEGYFDEMVHRVQNGRLNEQFMEGFESDDDDGFED-----------------------------------------------------------------------EDDVPGLGIAVYRGRRRVRREALKQANLDIQEAETAGRNVGGFGDEEDRNNRGHDQDRSFLDHYYP------------PMVVVVETESPQIVRDQEMMRQFEEAKKNVETDEIKKRAEAMQFGTSSSHHHTK--------------------------------------TLLIQRALFDKTSSVRR-------------------------------------------------------------------------------------------------------SLLQFITISVDQEELRQS------CHATSAPQGAHVVHNVVDEFDSIMRAQEDSNNRILLSLDIPAP----SAVTGVSGSITHADNSALQLQQEQPTSSFSSWFPEDDPIYALPPPPPPPAPPRRRRSADNK------DDSE-------NIPKKPRHQF---------