>Homo_sapiens-PDK2(ENSP_420927) ---------------------------------------MRWVWALLKNAS----------------------------L AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSW-YVQSL LDIMEFLDKDPEDHRTLSQ--------------------FTDALVTIRN-RHNDVVPTMAQGVLEYKDTYG---DDPVSN QNIQYFLDRFYLSRISIRMLINQHT---LIFDGSTN--PAHPKHIGSIDPNCNVSEVVK---DAYDM-AKLLCDKYYMAS PDLEIQEIN-AANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHE--SSLILPPIKVMVALGEEDLSIK------MSD RGGGVPLRKIERLFSYMYSTAPTPQPGTGG--TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK---ALST DSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS------------- >Macaca_mulatta-PDK2(ENSMMUP_19264) ---------------------------------------MRWVWALLKNAS----------------------------L AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSW-YVQSL LDIMEFLDKDPEDHRTLSQ--------------------FTDALVTIRN-RHNDVVPTMAQGVLEYKDTYG---DDPVSN QNIQYFLDRFYLSRISIRMLINQHT---LIFDGSTN--PAHPKHIGSIDPNCNVSEVVK---DAYDM-AKLLCDKYYMAS PDLEIQEIN-G----ESVAMCVSVLGLGTQQGKVRWGVRRWTVSRQG--RS------RVIIVLLIHLINIW------TGH SGS----------HLYMYSTAPTPQPGTGG--TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK---ALST DSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS------------- >Gorilla_gorilla-PDK2(ENSGGOP_15203) ARQGKGREEAAEPRRWAERCASAARAGTTT--QVAAAAAMRWVWALLKNAS----------------------------L AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSW-YVQSL LDIMEFLDKDPEDHRTLSQ--------------------FTDALVTIRN-RHNDVVPTMAQGVLEYKDTYG---DDPVSN QNIQYFLDRFYLSRISIRMLINQHT---LIFDGSTN--PAHPKHIGSIDPNCNVSEVVK---DAYDM-AKLLCDKYYMAS PDLEIQEIN-AANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHE--SSLILPPIKVMVALGEEDLSIK------MSD RGGGVPLRKIERLFSYMYSTAPTPQPGTGG--TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK---ALST DSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS------------- >Mus_musculus-PDK2(ENSMUSP_41447) ---------------------------------------MRWVRALLKNAS----------------------------L AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLGTPSVQLVQSW-YVQSL LDIMEFLDKDPEDHRTLSQ--------------------FTDALVTIRN-RHNDVVPTMAQGVLEYKDTYG---DDPVSN QNIQYFLDRFYLSRISIRMLINQHT---LIFDGSTN--PAHPKHIGSIDPNCSVSDVVK---DAYDM-AKLLCDKYYMAS PDLEIQEVN-ATNANQPIHMVYVPSHLYHMLFELFKNAMRATVESHE--SSLTLPPIKIMVALGEEDLSIK------MSD RGGGVPLRKIERLFSYMYSTAPTPQPGTGG--TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK---ALST DSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS------------- >Oryctolagus_cuniculus-PDK2(ENSOCUP_23... ---------------------------------------MRWVRALLKNAS----------------------------L AGAPKYIEHFSKFSPSPLSIKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLGTPSVQLVQSW-YVQSL LDIMEFLDKDPEDQRTLNQ--------------------KLVALCTSSTGRRNGEKATVQNGERKKKNKTV---LYLKRL QNVN-------LCRL-VTVLFLTTA---LLFDGSTN--PAHPKHIGSIDPNCNVSEVVK---DAYDM-AKLLCDKYYMAS PELDIQEVN-AANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHE--SSLVLPPIKVMVALGEEDLSIK------MSD RGGGVPLRKIERLFSYMYSTAPTPQPGTGG--TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK---ALST DSVERLPVYNKSAWRHYQPIQEAGDWCVPSTEPKNTSTYRVS------------- >Bos_taurus-PDK2(ENSBTAP_11523) -------GRRGTGPDWAEQSASAARAGSRTRVLEVVAIAMRWVRALLKNAS----------------------------L AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSW-YVQSL LDIMEFLDKDPEDHRTLSQ--------------------FTDALVTIRN-RHNDVVPTMAQGVLEYKDTYG---DDPVSN QNIQYFLDRFYLSRISIRMLINQHT---LLFDGRTN--PAHPKHIGSIDPNCNVSEVVK---DAYDM-AKLLCDKYYMAS PDLEIQEIN-ASNSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHE--SSVTLPPVKVMVALGEEDLSIK------MSD RGGGVPLRKIDRLFSYMYSTAPTPQPGTGG--TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK---ALST DSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS------------- >Pteropus_vampyrus-PDK2(ENSPVAP_6479) ---------------------------------------MRWVRALLKNAS----------------------------L AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSW-YVQSL LDIMEFLDKDPEDRQTLSQ--------------------FTEALVTIRN-RHNDVVPTMAQGVLEYKDAYG---DDPVSN QNIQYFLDRFYLSRISIRMLINQHT---LIFDGSTN--PAHPKHIGSIDPNCSVSEVVK---DAYDM-AKLLCDKYYMAS PDLEIQEIS-ASNSKQPIHMVYVPSHLYHILFELFKNAMRATVESHE--SSLILPPIKIMVALGKEDLSIK------MSD QGGGVPLRKIERLFSYMYSTAPTPQLGTGG--TPLAGFGYGLPISRLYAKYFQGDLHLFSMEGFGTDAVIYLK---ALST DSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS------------- >Monodelphis_domestica-PDK2(ENSMODP_15... -------------------------------------------------------------------------------- --?PKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLGTPSVQLVQSW-YVQSL LDIMEFLDKDPEDHRTLGQ--------------------FTDALVTIRN-RHNDVVPTMAQGVLEYKEAYG---DDPVSN QNIQYFLDRFYLSRISIRMLINQHT---LIFDGSTN--PAHPKHIGSIDPNCDVSEVVK---DAYDM-AKLLCDKYYMAS PSLEIQEIN-ASNSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHE--SSLTLPPIKVMVALGEEDLSIK------MSD RGGGVPLRKIERLFSYMYSTAPTPQLGTGG--TPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK---ALST DSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS------------- >Taeniopygia_guttata-PDK2(ENSTGUP_15019) -------------------------------------------------------------------------------- --------------------------GSSNACEKTSFAFLRQELPVRLSNIMKEINLLPDRVLRTPSVQLVQSW-YVQSL LDIMEFHDRDPEDQATLGQ----------------------AALVSPRA-TPSPGAAGASSGFCQRPHLAG----NPGLN RAVPRDLFKCSLSVFSHSWHVKILL----LYPDGLF--LMCASVIRKTTQPDSLQESIL---PAVGL-IRLPLILGSGLS PPIPVSVPTPACNSEQPVSMVYVRSHLYHMLFELFKNAMRATVESHE--SSPRLPAIRVLVALGQEDLSIR------MSD RGMGVPLRKIERLFSYMYSTAPTPQLGSGG--APL--------------------------------------------- ------------------------------------------------------- >Danio_rerio-PDK2(ENSDARP_12861) ---------------------------------------MKFVRFIMKNAAL---------------------------- ANVPHHIEHFSKFSPSPLSMKQFLDFGSTNACEKTSFVFLRQELPVRLSNIMKEINLLPKRLLTTPSVQMVHSW-YIQSL MEILEFLEKSPDDHSILEE--------------------FVAALVNIRN-RHNDVVPTMAQGVIEYKEVFGQ---DPVTN QNIQYFLDRFYLSRISIRMLINQHT---LVFDGATN--PVHPNTIGSIDPHCQVADVVK---DAYES-ARMLCDQYYLNS PDLDLQELNT-NNRNQPISIVYVPSHLYHILFELFKNAMRATIENHK--EGSNLPAIQVMVAVGGEDLTIK------MSD RGGGVPFRKMENLFSYMYSTAPTPQMDEKQ-RAPLAGFGYGLPISRLYAKYFQGDLQLYSMEGHGTDAVIHLK---ALST DSVERLPVFNKTARRNYEVTQGADDWCVPSREPLDLAVFKLAK------------ >Oryzias_latipes-PDK2(ENSORLP_15232) ------------------------------RGAEINTATMKSVRFIMQNAAL---------------------------- ASLPKHIDHFSKFSPSPLSMKQFIDFGSINACEKTSFVFLRQELPVRLSNIMKEINLLPDKLLTTPSVQMVQRW-YIQSL MEILEFLDKNPDDQQILGD--------------------FADALVTIRN-RHNDVVPTMAQGVMEYKEVFPQ---DVVTN QNIQYFLDRFYMSRISIRMLINQHT---LVFNGTTN--PAHPTTIGSIEPHCQVGEVVQ---DAFHS-AKMLCDQYYLRS PDLLLQEMNH-KKTSHPISIVYVPSHLYHMLFELFKNAMRATIETHE--NKNNLPPIKALVSLGGEDMSIK------VSD VGGGVPFRKIENLFSYMYSTAPTPQIGEHT-RTPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTDAVIYLK---ALST DSVERLPVYNKTALKNYKICQEADDWCVPSKEPLDLRKYRVA------------- >Takifugu_rubripes-PDK2(ENSTRUP_33230) ---------------------------------------MKFVRFIMKNAAL---------------------------- ASAPKHIEHFSKFSPSPLSMKQFLDFGSINACEKTSFVFLRQELPVRLSNIMKEINLLPDRLLTTPSVQMVQSW-YIQSL MEILEFLDRNPDDHKVLGQ--------------------FVDTLVTIRN-RHNDVVPTMAQGIIEYKEAFPQ---DPVTN QNIQYFLDRFYTSRISIRMLINQHT---LIFDGTAN--PVHPNTIGSIDPHCHVGDVVQ---DAFHS-AKMLCDQYYLRS PDLVLREMS--GKKNPPVSIVYVPSHLYHMLFELFKNAMRATIETHE--SSDHLPPVHVLVSLGDEDVSIK------VCD TGGGVPFRRIENLFSYMYSTAPAPQLGEHT-RPPLAGFGYGLPISRLYAKYFQGDLQLYSMEGHGTDAVIYLK---ALST DSIERLPVYNKTALKNYQLRQEADDWCVPSKEPLDLSNYKGPK------------ >Takifugu_rubripes-PDK2(ENSTRUP_21884) ---------------------------------------MKFVRSLMKAAAL---------------------------- ANVPKHIDHFSKFSPSPLSMKQFLDFGTINACERTSFVFLRQELPVRLSNIMKEINLLPDRLLGTPSVQLVQSW-YTQSL MEILEFLDKTPDDQSVLET--------------------FLEVLETIRN-RHNEVVPTMAQGVIEYKDAFDQQ--DAVTD HNIQYFLDRFYTSRISIRMLINQHSN--SCVQWQHK--PGSPNTIGCIDSVCDVTEVTR---DAYES-AKLLCEQYYLGA PELELRQMNA-NNVREPIQISYVPSHLYHMLFELFKNAMRATIETHE--SSRTLPPIKVMIALGGEDLSIK------MSD RGGGVPFRRTERLFSYMYSTAPRPCIEDKH-RAPLAGFGYGLPISRLYARYFQGDLQLFSMEGNGTDAIIHLK---ALST DSVERLPVFNKSALRHYKLSLEADDWCVPSKEPLNLANYRAQK------------ >Tetraodon_nigroviridis-PDK2(ENSTNIP_2... ------------------------------------AAAMKLVRFIARSAAL---------------------------- ASAPTHIEHFSKFSPSPLSMKQFLDFGSINACEKTSFVFLRQELPVRLSNIMKEINLLPGRLLTTPSVQMVQSW-YIQSL MEILEF-DKNPDDHKVLGE--------------------FVDALVTIRN-RHNDVVPTMAQGILEYKEAFPQ---DPVTN QNIQYFLDRFYTSRISIRMLINQHT---LIFDGSAN--PVHPNTIGSIAPHCQVGDVVQ---DAFHS-AKMLCDQYYLCS PDLVLQEMSA-GEKKPPISIVYVPSHLYHMLFELFKNAMRATIETHE--NSDQLPPVHVMVALGDEDVSIK------VSD TGGGVPFRKIENLFSYMYSTAPAPQIGQHA-RTPLAGFGYGLPISRLYAKYFQGDLQLYSMEGHGTDAVIYLK---ALST DSIERLPVYNKTALKNYRLRQEADDWCVPSKEPLDLSSYKVP------------- >Tetraodon_nigroviridis-PDK2(ENSTNIP_4... ---------------------------------------MKLVRSLMKTAAL---------------------------- ANVPKHIEHFSKFSPSPLSMKQFLDFGTINACERTSFVFLRQELPVRLSNIMKEINLLPDRLLGTPSVQLVQSW------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Gasterosteus_aculeatus-PDK2(ENSGACP_5... -------RSLVLPCWSFASLVAKRRNPSREPGPPPKATTMKFVRYIMKNAAL---------------------------- ASVPKHVDHFSKFSPSPLSMKQFLDFGSINACEKTSFVFLRQELPVRLSNIMKEINLLPSKLLTTPSVQTVQSW-YIQSL MEILEFLDKNPDD-KVLGE--------------------FVDSLVTIRN-RHNHVVPTMAQGIIEYKEAFPQ---DQVTN QNIQYFLDRFYMSRISIRMLINQHT---LVFDGTLN--PVHPNTIGSIDPHCEVGDVVQGVPDAFRS-AKMLCDQYYLRS PDLILQEMCRTKKKNLPISIVYVPSHLYHMLFELFKNAMRATIETHD--HSSTLPPVEVMVALGDEDLSIK------MSD RGGGVPFRRMDKLFSYMYSTAPAPRIGERT-RPPLAGFGYGLPISRLYAQYFQGDLQLFSMEGHGTDAVIYLK---ALST DSVERLPVYNKTALKNYKVSLEVDDWCIPSREPLDLSVHKVP------------- >Homo_sapiens-PDK4(ENSP_5178) ---------------------------------------MKAARFVLR-SAGSLNGA----------------------- GLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSW-YIQSL MDLVEFHEKSPDDQKALSD--------------------FVDTLIKVRN-RHHNVVPTMAQGIIEYKDACT---VDPVTN QNLQYFLDRFYMNRISTRMLMNQHI---LIFSD-SQ--TGNPSHIGSIDPNCDVVAVVQ---DAFEC-SRMLCDQYYLSS PELKLTQVN-GKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQE--NQPSLTPIEVIVVLGKEDLTIK------ISD RGGGVPLRIIDRLFSYTYSTAPTPVMDN-SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLK---ALSS ESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM------------- >Macaca_mulatta-PDK4(ENSMMUP_28178) ---------------------------------------MKAARFVLR-SAGSLSGA----------------------- GLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILREIDILPTQLINTSSVQLVKSW-YIQSL MDLVEFHEKSPDDQKALSD--------------------FVDTLIKVRN-RHHNVVPTMAQGIIEYKDACT---VDPVTN QNLQYFLDRFYMNRISTRMLMNQHI---LIFSD-SQ--TGNPTHIGSIDPNCDVVAVVQ---DAFEC-SRMLCDQYYLTS PELKLTQVN-GKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQE--NRPSLTPIEVIVVLGKEDLTIK------ISD RGGGVPLRIIDRLFSYTYSTAPTPVMDN-SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLK---ALSS ESIEKLPVFNMSAFKHYQMSSEADDWCIPSREPKNLAKEAAM------------- >Gorilla_gorilla-PDK4(ENSGGOP_2427) ---------------------------------------MKAARFVLR-SAGSLNGA----------------------- GLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSW-YIQSL MDLVEFHEKSPDDQKALSD--------------------FVDTLIKVRN-RHHNVVPTMAQGIIEYKDACT---VDPVTN QNLQYFLDRFYMNRISTRMLMNQHI---LIFSD-SQ--TGNPSHIGSIDPNCDVVAVVQ---DAFEC-SRMLCDQYYLTS PELKLTQVN-GKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQE--NQPSLTPIEVIVVLGKEDLTIK------ISD RGGGVPLRIIDRLFSYTYSTAPTPVMDN-SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLK---ALSS ESVEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM------------- >Mus_musculus-PDK4(ENSMUSP_19721) ---------------------------------------MKAARFVMR-SASSLSSA----------------------- SLVPREVELFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPDRLVNTPSVQLVKSW-YIQSL MDLVEFHEKSPEDQKALSE--------------------FVDTLVKVRN-RHHNVVPTMAQGILEYKDTCT---VDPVTN QNLQYFLDRFYMNRISTRMLMNQHI---LIFSD-SK--TGNPSHIGSIDPNCDVVAVVQ---DAFEC-AKMLCDQYYLTS PELNLTQVN-GKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQE--NRPSLTPVEATVVLGKEDLTIK------ISD RGGGVPLRITDRLFSYTYSTAPTPVMDN-SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLK---ALSS ESVEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEKLAV------------ >Oryctolagus_cuniculus-PDK4(ENSOCUP_14... ---------------------------------------MKAARFVMR-SAGSLSGA----------------------- GLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPERLINTSSVQLVKSW-YIQSL MDLVEFHEKSPDDQKALSD--------------------FVDTLIKVRN-RHHNVVPTMAQGIIEYKDACT---VDPITN QNLQYFLDRFYMNRISTRMLMNQHI---LIFSD-AQ--TGNPSHIGSIDPNCDVAAVVQ---DAFES-SKMLCDQYYLTS PELKLTQVN-GKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQE--NWPSLTPIEVIVVLGKEDLTIK------ISD RGGGVPLRITDRLFSYTYSTAPTPVMDN-SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLK---ALSS ESVEKLPVFNKSAFKHYQMSSEADDWCIPSKEPKNLAKEKVAA------------ >Bos_taurus-PDK4(ENSBTAP_38686) ---------------------------------------MKAARFVMR-SAGTL-------------------------- --IPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIYILPDRLVNTSSVQLVKSW-YMQSL MELVEFHEKSPEDQKALSD--------------------FVDTLIKVRN-RHHDVIPTMAQGILEYKDACT---VDPVTN QNLQYFLDRFYMNRISTRMLMNQHI---LIFGD-LQ--TGNPSLIGSIDPNCDVAAVVQ---DAFEC-SKMLCDQYYLTS PELNLTQVN-VKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQQ--NWPSLTPIQVIVVLGKEDLTIK------ISD RGGGVPLRVIDRLFSYTYSTAPTPVMDN-SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLPGYGTDAIIYLK---ALSS ESIEKLPVFNKSAF-HYQTSSEAGDWCIQAG-TKNLARKKCCV------------ >Pteropus_vampyrus-PDK4(ENSPVAP_11022) ---------------------------------------MRVARFVMR-SAGSL-------------------------- --IPREVEHFSRYSPSPLSMKQLLDFGSESACERTSFAFLRQELPVRLANILKEIDILPDQLINTASVQLVKSW-YIQSL MDLVEFHERNPEDQKVLSD--------------------FVDTLIEVRN-RHHNVVPTMAQGIIEFKDGCT---VDPITN QNLQYFLDRFYMNRISTRMLMNQHI---LIFSD-LQ--TRNPSHIGSIDPKCDVVAVVQ---DAFEC-SRMLCDQYYLTS PELKLTQVN-EKFPGQPIHIVYVSSHLHHMLFELFKNAMRATVEHQE--NQPSLTPIEVIVVLGKEDLTIK------ISD RGGGVPLRIIDRLFSYTYSTAPTPVMDN-SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLK---ALSS ESIEKLPVFNKSAFKHYQMSNEADDWCVPSKEPKNLANEKVAV------------ >Monodelphis_domestica-PDK4(ENSMODP_20... -------------------------------------------------------------------------------- ------VERFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPDRLVKTASVQLVKSW-YIQSL MDLVEFHEKSPDDHKALSD--------------------FVDALIKVRN-RHHDVVPTMAQGILEYKDSGA---ADAGSS QNLQYFLDRFYMNRISTRMLMNQHI---LIFGE-SK--SGNPSHIGSIDPHCDVVAVVQ---DAYES-ARLLCDQYYLVS PELKLAQVN-GKLPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQE--SQPALTPIDVTVVLGNEDLTIKASTFSGISD RGGGVPLRIIDRLFSYTYSTAPTPVMDN-SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLK---ALSS ESVEKLPVFNKSAFKHYQTSLAADDWCAPSKEPRNLSKEKAEA------------ >Ornithorhynchus_anatinus-PDK4(ENSOANP... ---------------------------------------MNAARLMLR-GAGSLSSS----------------------- --VPREVEHFSRYSPSPLSIKQLLDFGTENACERTSFAFLRQELPVRLANILKEIDILPDRLVNTSSVQLDKAWVYIQSL MDLVEFHEKNPDDQKALSD--------------------FIDALITVRN-RNHNVVPTMAQGIIEYKDACP---VDLVTN QNLQYFLDRFYMNRISTRMLMNQHI---LIFSD-TK--TGNPSHIGSIDPNCDVVSVVQ---DAFES-SLLLCEL--ISR PEIFLSLLL-GKVPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQE--NCPSLSPIEVTVVLGKEDLTIK------ISD RGGGVPLRITDRLFSYTYTTAPTPVMDN-SRNAPLVGDSLASSLPRL--------------------------------- ------------------------------------------------------- >Gallus_gallus-PDK4(ENSGALP_15774) ---------------------RRLADRLTEHPPTAATAAMKAARIALR-TAVPLAGA-----------------GGVRSS -RLPREVEQFSRFSPSPLSIKQLLDFGSTNGCERTSFAFLRQELPVRFANILREIELLPDKLLSTPSVQLVKSW-YIQSL MELVEFHQKSPDDQKVLSE--------------------FIDTLIRVRN-RHHDVVPTMAQGVIEYKDMFK---VDPVTN QNIQYFLDRFYMSRISTRMLMNQHTKTALLFDDKSR--SGHPRHIGSIDPCCDVVEVVN---DAFQS-SKMLCDQYYLTS PELKLNQVN-GKFPGEPINIVYVPSHLFHMLFELFKNSMRATVEFQE--NSPSLSPVEVTVVLGQEDLAIK------ISD RGGGVPVRKIEQLFSYMYSTAPRPRMDD-GRQTPLAGFGYGLPISRLYAKYFQGDLNLYSICGYGTDAIIYLK---A--- ------------------------------------------------------- >Taeniopygia_guttata-PDK4(ENSTGUP_1637) ---------------------------------------MKAARIALR-SAAPLAGAN----------------AGSSSG -RLPKEVEQFSRFSPSPLSIKQLLDFGSTNGCERTSFAFLRQELPVRFANILKEIDLLPDRLLGTPSVKLVKSW-YIQSL QELIEFHQKSPDDQKVLSD--------------------FIDTLIRVRN-RHHDVVPTMAQGVIEYKDTYK---VDPVTN QNIQYFLDRFYMSRISTRMLMNQHT---LLFDDKSG--SGHPRHIGSIDPCCDVVEVVN---DAYES-AKLLCDQYYLTS PELKLTQVN-GKAPGEPISIVYVPSHLFHMLFELFKNSMRATVEFQE--NSPTLSPVEVTVVLGKEDLAIK------VSD RGGGVPVRKIERLFSYMYSTAPRPNVDD-GRNTPLAGFGYGLPISRLYAKYFQGDLNLYSICGYGTDAIIYLK---ALST ESIEKLPVFNKSASKHYQATSEADDWCVPSKDPKNMAKQSAAS------------ >Anolis_carolinensis-PDK4(ENSACAP_13895) ---------------------------------------MKAARIALR-NAGPLATTS----------------HGLPSS GRATREVEHFARYSPSPLSIKQFLDFGSTNACERTSFSFLRHELPVRLANILKEIDLLPSPLLSTPSVQLVKSW-YVQSL MELVEFHDKKSDDHKVLSD--------------------FIDAIIKVRN-RHHDVVPTMAQGVLEYRDSSK---MDPFIN QNIQYFLDRFYMNRISIRMLINQHT---LIFDNNNS--IGNPRHIGCIDPCCDVVDLVH---DAFQS-AQMLCDQYYFAS PELKLTQVN-GKTAGQPIHIVYVPSHLFHMLFELFKNAMRATVEHQE--SKPSLDPVEVTVVLGKEDLSIK------ISD RGGGVPVRKIESLFSYTYSTAPKPVMDN-NNTTPLAGFGYGLPISRLYAKYFHGDINLCSISGYGTDALIYLK---ALST ESIEKLPVFNKSACKHYQTPIEADDWCVPSKEPKNLSRQSAAA------------ >Danio_rerio-PDK4(ENSDARP_71589) ---------------------------------------MYICKDFTSVSQCSLLHN----------------------- IKLARLVTILVCSSRVKFLRSPVLLSGSANACEKTSFMFLRQELPVRLANIMKEIDFLPDKLLGTPSLKLLQSW-YAQSL MELVDFLEKDPDDKKILTK--------------------FTETLINVRN-RHNNVVPTMAQGVLEYKEAFG---VDPVTN QNVQYFLDRFYMSRISTRMLMNQHT---LIFDGSTN--PAHPKHIGSIDPNCDVVEVVR---DAYES-SKMLCDQYYLTS PEVEIKQVN-IKGPSDPIHIVYVPSHLYHMLFELFKNAMRATVETHE--TSLHLPPIKVRVSLGTEDLTIK------MSD RGSGVPLRKIERLFSYMYSTAPSPVAED-TRNAPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLK---ALST ESIERLPVFNKSALRHYQTSTEADDWCIPSSEPKKLGKYEFSV------------ >Oryzias_latipes-PDK4(ENSORLP_5600) ----------------------------------LTGITMKFAQFWR--SKGSFSG------------------------ --ILKQVERFSKFSPSPLSMKQFIDFGSTNACEKTSFVFLRQELPVRLANIMKEIDYLPDKLLSTPSVKLLNSW-YSRSL MELVDFLEKDPDDKDVLKN--------------------FTKTLVNVRN-RHNNVVPTMAQGVLEYKDAFG---VDPVTN QNVQYFLDRFYMSRISTRMLMNQHT---LIFDGSVN--PAHPKHIGSIDPSCDVVEVVK---DAFET-SKMLCEQYYLTS PDMEITEVN-SKNPDQPLHIVYVPSHLYHMLFELFKNAMRATVETHE--TSPTLPPIKVRISLGSEDLTIK------MSD KGGGVPLRKIERLFSYMYSTAPSPVHMDNSRNAPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLK---ALSS ESVERLPVFNKSALRHYQTSMEADDWCMPSKDPKKLGKNEMT------------- >Takifugu_rubripes-PDK4(ENSTRUP_40834) ---------------------------------------MKFGQFLW--KNASVLG------------------------ --IPKQVERFSKFSPSPLSMKQFLDFGSANACEKTSFVFLRQELPVRLANIMKEIDFLPDKLLGTPSLKLLTSW-YSQSL LDLVEFLEKDPDDKEVLTS--------------------FTQALVNIRN-RHNNVVPTMAQGVLEYKEAFG---VDPVTN QNVQYFLDRFYMSRISIRMLMNQHT---LIFEGSVN--PAHPKHIGSIDPSCDVVEVVK---DAYET-SKMLCEQYYLTS PDMEITEVN-SKSPNQPLDIVYVPSHLYHMLFELFKNAMRATVETHE--TSATLPPVKVRVSLGSEDLTIK------MSD RGGGVPLRKIERLFSYMYSTAPSPVHVDNSRNAPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLK---ALSS ESVERLPVFNKSALRHYRASTEADDWCMPSKDPRKLGKSERTQ------------ >Gasterosteus_aculeatus-PDK4(ENSGACP_8... ---------------------------------------MKFAQFLL--KSSSVSG------------------------ --IPRQVERFAKFSPSPLSMKQFIDFGSADACEKTSFVFLRQELPVRLANIMKEIDFLPDKLLGTPSLKLLISW-YSQSL MEIVDFLEKDPDDKDVLTN--------------------FTQTLVNVRN-RHNNVVPTLAQGVVEYKDAFG---VDPVTN QNVQYFLDRFYMSRISTRMLMNQHT---LIFDGSVN--PAHPKHIGSIDPSCAVVEVIK---DAYDT-SKMLCEQYYLTS PDMEIIEVN-SKNPDQPLHIVYVPSHLYHMLFELFKNAMRATVETHE--TSPALPPIKVRVSLGTEDLTIK------MSD RGGGVPLRKIERLFSYMYSTAPSPVHMDNSRNAPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLK---ALSS ESVERLPVFNKSALRHYQTSIEADDWCMPSRDPKKLGNSKEKQKYFKLNRTH--- >Homo_sapiens-PDK1(ENSP_376352) ---------------------------------------MRLARLLRGAALAGPGPGLRAAGF--SRSFSSDSGSSPASE RGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YIQSL QELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIRN-RHNDVIPTMAQGVIEYKESFG---VDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKGKGSPSHRKHIGSINPNCNVLEVIK---DGYEN-ARRLCDLYYINS PELELEELN-AKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHA-NRG-VYPPIQVHVTLGNEDLTVK------MSD RGGGVPLRKIDRLFNYMYSTAPRPRVETSR-AVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST DSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFR----SA--------- >Macaca_mulatta-PDK1(ENSMMUP_38143) -------------------------------------------------------------------------------- --------------------------GSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YIQSL QELLDFKDKSAEDAKAIYERPK-TWLQVSSLFSMACK-IFTDTVIRIRN-RHNDVIPTMAQGVIEYKESFG---VDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKGKGSPSHRKHIGSINPNCNVVEVIK---DGYEN-ARRLCDLYYINS PELELGELN-AKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHA-NRG-VYPPIQVHVTLGNEDLTVK------MSD RGGGVPLRKIDRLFNYMYSTAPRPRVETSR-AVPLVLCFCQLPSTCSSCQISGIRINKILIECYLICFFFFFQ---ALST DSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFR----SA--------- >Gorilla_gorilla-PDK1(ENSGGOP_4049) ---------------------------------------MRLARLLRGAALAGPGPGLRAAGS--SRSFSSDSGSSPASE RGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YIQSL QELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMACKMIFTDTVIRIRN-RHNDVIPTMAQGVIEYKESFG---VDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKGKGSPSHRKHIGSINPNCNVVEVIK---DGYEN-ARRLCDLYYINS PELELEELN-AKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHA-NRG-VYPPIQVHVTLGNEDLTVK------MSD RGGGVPLRKIDRLFNYMYSTAPRPRVETSR-AVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST DSVERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFR----SA--------- >Mus_musculus-PDK1(ENSMUSP_6669) ---------------------------------------MRLARLLRGGTSVRPLCAVPCASR--SLASASASGSGPASE LGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YIQSL QELLDFKDKSAEDAKTIYE--------------------FTDTVIRIRN-RHNDVIPTMAQGVTEYKESFG---VDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKG--SPSHRKHIGSINPNCDVVEVIK---DGYEN-ARRLCDLYYVNS PELELEELN-AKSPGQTIQVVYVPSHLYHMVFELFKNAMRATMEHHA-DKG-VYPPIQVHVTLGEEDLTVK------MSD RGGGVPLRKIDRLFNYMYSTAPRPRVETSR-AVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST ESVERLPVYNKAAWKHYKANHEADDWCVPSREPKDMTTFR----SS--------- >Oryctolagus_cuniculus-PDK1(ENSOCUP_357) -------------------------------------------------------------------------------- --------------------------GSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YIQSL QELLDFKDKSAEDAKAVYD--------------------FTDTVIRIRN-RHNDVIPTMAQGVIEYKESFG---VDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKG--SPSHRKHIGSINPNCNVVEVIK---DGYEN-ARRLCDLYYINS PELELEELN-AKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHA-DKG-VYPPIQVHVTLGNEDLTVK------MSD RGGGVPLRKIDRLFNYMYSTAPRPRVETSR-AVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST ESIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFR----SA--------- >Bos_taurus-PDK1(ENSBTAP_38331) ---------------------------------------MRLARLLRVATSAGPGPELRAAGPSVSRSLTSDSGSGPAPE RGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YIQSL QELLEFKDKSAEDAKTIYD--------------------FTDTVIRIRN-RHNDVIPTMAEGVVEYKESFG---VDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKGKGSLSHRKHVGSINPNCSVVEVIK---DGYEN-ARRLCDLYYINS PELELEELN-AKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHA-DKG-VYPPIQVHVTLGKEDLTVK------MSD RGGGVPLRKIDRLFNYMYSTAPRPRVETSR-AVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST ESIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFR----SA--------- >Pteropus_vampyrus-PDK1(ENSPVAP_10686) ---------------------------------------MRLARLLRGAASAGPGP--RTFRSSASRSLTSDSGSGPAPE RGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YIQSL QELLDFKDKSADDAKTIYERSIKTCLWVSSL-AVVCKIIFTDTVIRIRN-RHNDVIPTMAQGVIEYKESFG---VDPVTS QNVQYFLDRFFMSRISIRMLLNQHS---LLFGGKNKGSPSHRKHIGSINPNCNVVEVIQ---DGYEN-ARRLCDLYYINS PELELEELN-AKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEYHA-DKG-VYPPIQVHITLGNEDLTVK------MSD RGGGVPLRKIDRLFNYMYSTAPRPRVETSR-AAPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST DSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFR----SA--------- >Monodelphis_domestica-PDK1(ENSMODP_11... ---------------------------------------MRLVRYLRRAVSASPGP---------GPGPSPNPGPGAGPE RSVPGPVDFYSRFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YIQSL QELLYFKNKSAEDAKAVYD--------------------FTDTVIRIRN-RHNDVIPTMAQ-CDEYKESFG---VDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKGKGSSTHRKHIGSINPNCNVVEVIK---DGYEN-AKRLCDLYYVNS PELELEELN-AKSPGQPMQVVYVPSHLYHMVFELFKNAMRATMEHHA-DKG-VYPPIQVHVTLGNEDLTVK------MSD RGGGVPLRKIDRLFNYMYSTAPRPRVETSR-AVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST ESVERLPVYNKAAWKHYNTNHEADDWCVPSSEPKDMTTFR----SV--------- >Ornithorhynchus_anatinus-PDK1(ENSOANP... -------------------------------------------------------------------------------- --------------------------GSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YIQSL QELLDFKDKSAEDSKTIYD--------------------FTDTVITIRN-RHNDVIPTMAQGVVEYKESFG---VDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKNKGSTAHRKHIGSINPNCNVVEVIK---DGYEN-ARSLCDLYYINS PELKLVELN-AKSPGQPMQVVYVPSHLYHMVFELFKNAMRATMEHHA-DKG-VYPPIHVHVTLGNEDLTVK------MSD RGGGVPLRKIDRLFNYMYSTAPRPRVETSR-AVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST ESVERLPVYNKSAWKHYKTNHEADDWCVPSSEPKDMTTFR----SA--------- >Gallus_gallus-PDK1(ENSGALP_21580) ---------------------------------------MRLLRALLRCASP---------------------------- GSIPQQVDFYSRFSPSPLSMKQFLDFGSENACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YVQSL QEILDFKDKSSEDSGAIHS--------------------FTDTVIKIRN-RHNDVIPTMAQGVIEYKESFG---IDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKIN--PAHPKHIGSIDPSCNVVGVIR---DGYES-AKSLCDLYYMSS PELVLEELN-IKSPGQPMQVVYVPSHLYHMVFELFKNAMRATMEHNA-DRC-IYPPIHVHVTLGNEDLTVK------MSD RGGGVPMRKIDRLFNYMYSTAPRPRVETSR-ATPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST ESIERLPVYNKAAWKHYKANHEADDWCVPSSEPKDMTTFR----ST--------- >Taeniopygia_guttata-PDK1(ENSTGUP_8792) ---------------------------------------MRLLRALLRGAAA---------------------------- GNIPQQVDFYSRFSPSPLSMKQFLDFGSENACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSW-YVQSL QEILDFKDKSSEDSGAIHS--------------------FTDTVIKIRN-RHNDVIPTMAQGVIEYKESFG---IDPVTS QNVQYFLDRFYMSRISIRMLLNQHS---LLFGGKIN--PAHPKHIGSIDPNCNVVEVIR---DGYEN-AKTLCDLYYMSS PELILEELN-SKSPGQPMQVVYVPSHLYHMVFELFKNAMRATMEHHA-DRS-IYPAIHVHITLGNEDLTVK------MSD RGGGVPMRKIDRLFNYMYSTAPRPRVETSR-ATPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK---ALST ESIERLPVYNKAAWKHYKANHEADDWCVPSSEPKDMTTFR----SM--------- >Danio_rerio-PDK1(ENSDARP_22009) ---------------------------------------MRIFRTLLN-------------------------------- -AASKQIDFYSRFSPSPLSMKQFIDFGSENACEKTSFTFLRQELPVRLANIMKEIDLLPDNLLRTPSVRLVQSW-YMQSF QDILEFKDKDADDETVNHD--------------------FTDAVIKIRN-RHNDVVPTMAQGVVEYKETYG---TDPITS QNMQYFLDRFYMSRISIRMLLNQHT---LLFGGKVRDNPAHPKQIGSIDPSCRVTDVVK---DAYEN-ARNLCDRYYMNS PELVLEEFN-VKGPDKPVTVVYVPSHLYHMVFELFKNAMRATMELYE-DAM-EYPPVHVQIVLGHEDLTVK------VSD RGGGVPLRKIDRLFTYTYSTAPRPQMDTSR-ATPLAGYGYGLPISRLYARYFQGDLKLYSMEGFGTDAVIYIR---ALST DSIERLPVYNKSAWKHYKTIHEADDWCVPSKEPKDMTTFR----SF--------- >Oryzias_latipes-PDK1(ENSORLP_21782) ---------------------------------------MRLLRFLR-------------------------------KS VAVGKDIDYYSKFSPSPLSMKQFLDFGSENACEKTSFAFLRQELPVRLANIMKEINLLPDNLLRTSSVSLVQSW-YMQSF QDILKFKDKNADNEKVTHE--------------------FTDAVIKIRN-RHNDVIPTMAQGVVEYKETYG---TDPVVS QNVQYFLDRFYMSRISIRMLLNQHT---LLFGGKV--NPAHPKQIGSIDPHCHVTEVIK---DAYEN-ARNLCDRYYMNS PDLILEEFN-AKEPGSPVTVVYVPSHLYHMVFELFKNAMRATMELCG-DTM-ECPPIQAQVALGSEDLTVK------VSD RGGGVPMRKIDRLFTYTYSTAPRPSIDGSS-GAPLAGYGYGLPISRLYARYFQGDLKLYSLEGYGTDAVIYIR---ALST ESIERLPVYNKSAWKHYKTIHEADDWCVPSKEPKDMTTFR----SF--------- >Takifugu_rubripes-PDK1(ENSTRUP_45340) ---------------------------------------MRILRFLR-------------------------------SS ISAGKDIDYYSKFSPSPLSMKQFLDFGSENACEKTSFAFLRQELPVRLANIMKEINLLPDNLLRTPSVRLVQSW-YMQSF QDILEFRDRNAEDEKVTHESVKVYILLVSGL-------SFTNAVIKIRN-RHNDVIPTMAQGVVEYKETYG---TDPVVS QNVQYFLDRFYMSRISIRMLLNQHT---LIFGGKV--NPAHPKQIGGIDPHCRVSDVVR---DAFEN-ARNLCDRYYMNS PELVLEEFN-VEEKEKPITVVYVPSHLYHMVFELFKNAMRATMELYG-DAM-EYPAVHAQVALGNEDLTVK------VSD RGGGVPLRKIDRLFTYTYSTAPRPSLDGSR-AAPLAGYGYGLPISRLYARYFQGDLKLYSLEGHGTDAVIYIR---ALST ESIERLPVYNKSAWKHYKTIHEADDWCVPSKEPKDMTTFR----SF--------- >Tetraodon_nigroviridis-PDK1(ENSTNIP_2... -------------------------QLLCRILLIKLNTRLTLLPCQRRQASRQTAT-----------------GSDDKNS VSAGKDIDYYSKFSPSPLSMKQFLDFGSENACEKTSFAFLRQELPVRLN-IMKEINLLPDNLLRTPSVRLVQSW-YMQSF QDILEFRDRNAEDEKVTHD--------------------FTDAVIKIRN-RHNDVVPTMAQGVVEYKETYG---TDPVVS QNVQYFLDRFYMSRISIRMLLNQHT---LLFGGKV--NPAHPNQIGSIDPHCGVSEVVR---DAFEN-ARNLCDRYYMNS PELVLEEFN-VEEKGKPVTVVYVPSHLYHMVFELFKNAMRATMELYG-DAM-EYPAIHAQVALGNEDLTVK------VSD RGGGVPLRKIERLFTYTYSTAPRPSLDGSR-AAPLAGYGYGLPISRLYARYFQGDLKLYSMEGHGTDAVIYIR---ALST ESIERLPVYNKSAWKHYKTIHEADDWCVP-KEPKDMTTFR----SF--------- >Homo_sapiens-PDK3(ENSP_387536) ---------------------------------------MRLFRWLLK-------------------------------- QPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPQVLDN--------------------FLQVLIKVRN-RHNDVVPTMAQGVIEYKEKFG---FDPFIS TNIQYFLDRFYTNRISFRMLINQHT---LLFGGDTN--PVHPKHIGSIDPTCNVADVVK---DAYET-AKMLCEQYYLVA PELEVEEFN-AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYE-DRKEGYPAVKTLVTLGKEDLSIK------ISD LGGGVPLRKIDRLFNYMYSTAPRPSLEPTR-AAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYK---AKQDKIKTNRTF >Macaca_mulatta-PDK3(ENSMMUP_16843) ---------------------------------------MRLFRWLLK-------------------------------- QPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPQVLDN--------------------FLQVLIKVR--RHNDVVPTMAQGVTIVISPKC---F-PVVN LLTCIFGCRNFISSLVFQLLTHQLS---LLFGGDTN--PVHPKHIGSIDPTCNVADVVK---DAYET-AKMLCEQYYLVA PELEVEEFN-AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYE-DRKEGYPAVKTLVTLGKEDLSIK------ISD LGGGVPLRKIDRLFNYMYSTAPRPSLEPTR-AAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYK---AKQ--------- >Gorilla_gorilla-PDK3(ENSGGOP_26417) ---------------------------------------MRLFRWLLK-------------------------------- QPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPQVLDN--------------------FLQVLIKVRN-RHNDVVPTMAQGVIEYKEKFG---FDPFIS TNIQYFLDRFYTNRISFRMLINQHT---LLFGGDTN--PVHPKHIGSIDPTCNVADVVK---VLSQTKAKVHCDIWYLVY VSLHCDDFS-AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYE-DRKEGYPAVKTLVTLGKEDLSIK------ISD LGGGVPLRKIDRLFNYMYSTAPRPSLEPTR-AAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYK---AKQ--------- >Mus_musculus-PDK3(ENSMUSP_36604) ---------------------------------------MRLFYRLLK-------------------------------- QPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPRVLDN--------------------FLNVLINIRN-RHNDVVPTMAQGVIEYKEKFG---FDPFIS SNIQYFLDRFYTNRISFRMLINQHT---LLFGGDTN--PAHPKHIGSIDPTCNVADVVK---DAYET-AKMLCEQYYLVA PELEVEEFN-AKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELHE-DKKEGYPAVKTLVTLGKEDLSIK------ISD LGGGVPLRKIDRLFNYMYSTAPRPSLEPTR-AAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYK---AKQDKIKSNRTF >Oryctolagus_cuniculus-PDK3(ENSOCUP_6414) ---------------------------------------MRLFQWLLK-------------------------------- QPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPQVLDN--------------------FLQVLIKVRN-RHNDVVPTMAQGVIEYKEKFG---FDPFIS SNIQYFLDRFYTNRISFRMLINQHT---LLFGGDTN--PAHPKHIGSIDPTCNVADVVK---DAYET-AKMLCEQYYLVA PELEVEEFN-AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYE-DRKEGYPAVKTLVTLGKEDLSIK------ISD LGGGVPLRKIDRLFNYMYSTAPRPSLEPTR-AAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSREPRDASKYK---AKQDKIKTNRTF >Bos_taurus-PDK3(ENSBTAP_23706) ---------------------------------------MRLFRLLLK-------------------------------- QPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPENLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPQVLDN--------------------FLQVLIKVRN-RHNDVVPTMAQGVIEYKEKFG---FDPFIS SNIQYFLDRFYTNRISFRMLINQHT---LLFGGDTN--PVHPKHIGSIDPTCNVADVVK---DAYET-AKMLCEQYYLVA PELEVEEFN-AKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELYE-DRKEGYPAVKTLVTLGKEDLSIK------ISD LGGGVPLRKIDRLFNYMYSTAPRPSLEPTR-AAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKSTAEADDWSNPSSEPRDASKYK---AKQDKMKTNRTL >Pteropus_vampyrus-PDK3(ENSPVAP_855) -------------------------------------------------------------------------------- ---------------------------RDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPKVLDN--------------------FLQVLIKVRN-RHNDVVPTMAQGVIEYKEKFG---FDPFIS SNIQYFLDRFYTNRISFRMLINQHT---LLFGGDTN--PAHPKHIGSIDPACSVADVVK---DAYET-AKMLCEQYYMAA PELEVEEFN-AKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELYE-DRKESYPSVKTLVTLGKEDLSIK------ITD LGGGVPLRKIDRLFNYMYSTAPKPSLEPSR-AAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYK---AKQ--------- >Erinaceus_europaeus-PDK3(ENSEEUP_12850) -------------------------------------------------------------------------------- ---------------------------RDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPQVLDN--------------------FLQVLINVRN-RHNDVVPTMAQGVIEYKEKFG---FDPFIS SNIQYFLDRFYTNRISFRMLINQHT---LLFGGDTN--PAHPKHIGSIDPTCNVADVVK---DAYET-AKMLCEQYYLVA PELEIEEFN-AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYE-DRKEAYPAVKTLVTLGKEDLSIK------ISD QGGGVPLRKIDRLFNYMYSTAPRPSLEPTR-AAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYK---VKQ--------- >Monodelphis_domestica-PDK3(ENSMODP_9219) ---------------------------------------MRLYRWLLK-------------------------------- QPVPKQIEQYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLSRPSVGLVQSW-YMQSF LEFLEYENKSPEDQQVLDD--------------------FLQDLIKVRN-RHNDVVPTMAQGVIEYKEKYG---FDPFIS SNIQYFLDRFYTNRISFRMLINQHT---LLFGDDTN--PSHPKHIGSIDPNCNVAEVVK---DAYET-AKMLCEQYYMVA PELEVEEFH-AKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYE-NRKEGYPSIKTLVTLGKEDLSIK------ISD HGGGVPLRKIDRLFNYMYSTAPRPSLEPSR-AAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPKDASKYR---AKLDKIKTNRTF >Gallus_gallus-PDK3(ENSGALP_26284) ---------------------------------------MRLCGALLK-------------------------------- SPIPKQIEYYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPHVLDD--------------------FLDVLIKVRN-RHNDVVPTMAQGVIEYKEKYG---FDPFVS SNIQYFLDRFYTNRISFRMLINQHT---LLFGGDIN--PAHPKHIGSIDPNCNVAEVVK---DAYET-AKMLCEQYYLVA PDLEVEEFN-AKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELHE-GKREGYPSIKTLVTLGKEDLSIK------ISD QGGGVPLRKIDRLFNYMYSTAPRPSLEPTR-AVPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGSDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYK---ANR--------- >Taeniopygia_guttata-PDK3(ENSTGUP_7416) ---------------------------------------MRLCGAMLK-------------------------------- SPIPKQIEYYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSW-YMQSF LELLEYENKSPEDPHVLDD--------------------FLDVLIKVRN-RHNDVVPTMAQGVIEYKEKYG---FDPFVS SNIQYFLDRFYTNRISFRMLINQHT---LLFGGDIN--PAHPKHIGSIDPNCDVTEVVK---DAYET-AKMLCEQYYTVA PDLEIEEFN-AKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELHE-GKKEAYPSIKTLVTLGKEDLSIK------ISD QGGGVPLRKIERLFNYMYSTAPRPSLEPSR-AVPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGSDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYK---ANR--------- >Anolis_carolinensis-PDK3(ENSACAP_7054) -------------------------------------------------------------------------------- --------------------------GRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVKLVQSW-YMQSF LELLEYENKSPEDPHVLDN--------------------FLDILIKVRN-RHNDVVPTMAQGVIEYKEKYG---FDPFVS SNIQYFLDRFYTNRISFRMLINQHT---LLFGGVTN--PAHPKHIGSIDPTCNVADVVE---DAFAT-AKMLCEQYYQAA PDLEIEEFN-AKAPGKPIQVVYVPSHLFHMLFELFKNSMRATVELHE-GKCESYPSIKALVTLGKEDLSIK------ISD KGGGVPLRKIDRLFNYMYSTAPRPSLEPSR-AVPLAGYGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKKCLTQQYNIKDKFSV >Danio_rerio-PDK3(ENSDARP_15430) ---------------------------------------MRLYAFLLQ-------------------------------- NHLPK-IEYYSRFSPSPLSIKQFLEFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDRLLSQPSVKLVQKW-YLQSF LELLEFENRKPEDGHALND--------------------FLETLIEIRN-RHNDVVPTMAQGVIEYKEKFG---FDPFVS SNIQYFLDRFYTNRISFRMLINQHT---LLFGNDIN--PAHPKHIGSIDPSCNVAEVVT---DAYET-AKMVCEQYYQAA PELKIEEFNAAKAPQKPIQAVYVPSHLFHMLFELFKNAMRATNDLHE-GSKEGLPLIKAKVTLGIEDLSVK------ISD RGGGVALRKIDRLFNYTYSTAPTPSLDSK--RVPLAGFGHGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYQGGPGADDWSNPSKEPRDTSKYK---AKTTDIKNTTSF >Danio_rerio-PDK3(ENSDARP_110197) ---------------------------------------MKLFICLLK-------------------------------- DVTHK-IEYYSRFSPSPMSIKQFLDFGRENACEKTSYMFLRKELAVRLANTMREVTLLPDSLQIQPSVKLVESW-YSQSF EELLKFEKRSPEDPHTLND--------------------FLEMLIKIRN-RHNDVVPTMAQGVIEYKEKFG---FDPFIS SNVQYFLDRFYTNRISFRMLINQHT---LLFGDAAC--LAQPKHIGSIDPACNVAEVVR---DAYET-AKMLCEQYYMMA PELKIGEFN-SKNPKKPVQAVYVPSHLFHMLFELFKNSMRATVELYE-NSSEGLPPVKAMVTLGKEDLSIK------ISD KGGGVPLRKIDRLFNYMYSTAPTPRLDPSQPAVPLAGFGYGLPISRLYARYFQGDLNLYSVEGFGTDAVIHLK---ALSS ESFERLPVFNKSAWRHYQTGPEADDWSNPSSDPRDASTYK---ATNLKIKSSIML >Oryzias_latipes-PDK3(ENSORLP_9459) ---------------------------------------MRLFLSLLK-------------------------------- NAHPK-IEYYSRYSPSPLSIKQFLDFGRDNACEKTSYVFLRKELPVRLANTMREVNLLPDKLLSQPSVRLVQKW-YMQSF VELLDYENRKPEDPHTLND--------------------FLEVLIEIRN-RHNDVVPTMAQGVIEYKEKFG---FDPFVS SNIQYFLDRFYTNRISFRMLINQHT---LLFGNDTN--PAHPKHIGSIDPTCNVAEVVK---DAYDT-AKMLCEKYYFAA PELKIEEFN-MKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELHE-NSAEGLPPVKTRVTLGKEDLSVK------ISD KGGGVPLRKIDRLFNYMYSTAPTPSLEPG--AVPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYKTSPEADDWSNPSKEPRDASKSI---YKANR------- >Takifugu_rubripes-PDK3(ENSTRUP_21358) -----------------------------KRLTRFNLHLGQVFTHVKK-------------------------------- NVNPK-IEYYSRFSPSPLSIKQFLDFGRENACEKTSYMFLRKELPVRLANTMKEVNLLPDKLLSQPSVKLVQKW-YMQSF VELLDYENRNPEDSHTLND--------------------FLELLIEIRN-RHNDVVPTMAQGVIEYKEKFG---FDPFIS SNVQYFLDRFYTNRISFRMLINQHT---LLFGNDTN--PAHPKHIGSIDPTCSVAEVVS---DAYDT-AKMLCEKYYLAA PKLKIEEFN-TKAAGKPIQVVYVPSHLFHMLFELFKNSMRATVELHE-TSREGLPPVKAKVTLGKEDLSIK------ISD RGGGVPLRKIDRLFHYMYSTAPTPSLEHG--AVPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKRYKALSS ESFERLPVFNKSAWRHYKTSAEADDWSNPSKEPRDASKSN---YKA--------- >Tetraodon_nigroviridis-PDK3(ENSTNIP_1... ---------------------------------------MRIFTFLLK-------------------------------- NSNPK-IEYYSKFSPSPLSIKQFLDFGRENACEKTSYMFLRKELPVRLANTMKEVNLLPDKLLGQPSVRLVQKW-YMQSF VELLDYENRNPEDAHTLND--------------------FLELLIEIRN-RHND-VPTMAQGVIEYREKFG---FDPFIS SNVQYFLDRFYTNRISFRMLINQHT---LLFGNDTN--PAHPKHIGSIDPTCSVAEVVN---DAYDT-AKMLCEKYYLAA PELSIQEFN-TKAAGKPIQVVYVPSHLFHMLFELFKNSMRATVELHQ-TSGEGLPPVKAKVTLGKEDLSIK------ISD RGGGVPLRKIDRLFHYMYSTAPTPSLEQG--AVPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYTTSPEADDWSNPSKEPRDASKSN---YKANR------- >Gasterosteus_aculeatus-PDK3(ENSGACP_3... ---------------------------------------MRIFTCLLK-------------------------------- NANPK-IEYYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDKLLSQPSVRLVQKW-YMQSF VELLDYENRKPEDCEALND--------------------FLELLIEIRN-RHNNVVPTMAQGVIEYKEKFG---FDPFIS SNVQYFLDRFYTNRISFRMLINQHT---LLFGDDTN--PAHPKHFGSIDPACSVAEVVS---DAYDT-AKMLCEKFYLDA PELKIEEFN-MKAPKRPIQAVYVPSHLFHMLFELFKNSMRATVELHE-NSEQGLPPIKAKVTLGKEDLSIK------ISD RGGGVPLRKIDRLFNYTYSTAPTPSLEPG--SVPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLK---ALSS ESFERLPVFNKSAWRHYTTTPEADDWSNPSTEPRDASKSN---FKAKR------- >Drosophila_melanogaster-PDK1(FBpp_111... ---------------------------------------MRLFPVRFSAASS--------------------------SM ASLAKMLDFYSGFNPSPLSIKQFMDFG-QNACEKKSYIFLRKELPVRLANIMKEIALLPDNLLHTRSVSEVSSW-YVKSF EDVLVYEKAEPTHDN-LQK--------------------FVADLDLIRN-RHNDVVQTMAQGVIEMKENEGG-QVDAPTE SSIQYFLDRLYMSRISIRMLINQHT---LLFGGNP---HAGGRHIGCLDPACDLSDVVR---DAYEN-ARFLCDQYYLTS PALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVEHHGHDNNDTLPPLKVAICKGKEDICVK------ISD QGGGIPRSQTDQLFKYMYSTAPQPSKSDLH-TVPLAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLK---ALSD EANELLPIFNKTSSKFYRATVPTGDWSNQSSDMNARQLSATTPKRCDFLQDA--- >Branchiostoma_floridae-PDK1(XP_2592098) --------------------------------------MMRLSPR---------------------------------IL KSLPALVDHYSRFSPSPLSIQQFLDFGSKNACEKKSFTFLRQELPVRLANIMKEINLLPDTLLKMPSVELVQSW-YIQSL TEILHFENKSPSDSAIIEN--------------------FTETLYNIRK-RHSNVVETMAQGVIELRDTHG---IDHQTD SNIQYFLDRFYMSRISIRMLIHQH---------ET---HP--RHVGSIDPNCEVESVVL---DAYEN-AKFLCDQYYLAS PELDLVSHNGIK-KSSPITVVYVPSHLYHMLFELFKNAMRAIVEYHGTAALD-YPKVKCQVSLGKEDLTIK------ISD QGGGIPKSAMDVLFNYMYSTAPQPPKSGST-TAPLAGYGYGLPLSRLYAKYFQGDLQLVSQEGYGTDALIWLK---ALSS EANELLPVFNTTSSRHYGTNIPTSDWSSPYTPRGS-QNSVRTFLTFRI-------