>Homo_sapiens-HDAC4(ENSP_264606) ---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSGPSSPN---------NSSGSVSAENGIAPAVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN ITLG---LPATGPSAGTAGQ------------------------------------------------------------ ------------------QDAERLTLPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LQMNK IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPGQKEAHA-------------QA-GVQVKQEPIESDEEE AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP LSRAQSSPASAT---FPVSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS ---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAVAAKLLQQRLS----VSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GAPD EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS MEKVMEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRCLQRTTSTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-PDEE PMEEEPPL--------------------------------------------------------------- >Macaca_mulatta-HDAC4(ENSMMUP_7984) ----------------------------------------------CLLSSPDGLSGRDQPVELLNPARVNHMPSTVDVA TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSGPSSPN---------NSSGSVSAENGITPAVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN ITLG---LPATGPAAGTAGQ------------------------------------------------------------ ------------------QDAERLTLPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHMNK IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPAQKEAHA-------------PA-GVQVKQEPIESDDEE AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP LSRAQSSPASAT---FPVSVL--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS ---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPIYATCRLQLLGVECRCRGLRAS----LLAQTRVRWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GAPD EVGLHARVSPDSNFSQTSACVAPRGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS MEKVMEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRCLQRATSTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-ADEE PMEEEPPL--------------------------------------------------------------- >Pan_troglodytes-HDAC4(ENSPTRP_22412) ---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA AALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSGPSSPN---------NSSGSVSAENGIAPTVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN ITLG---LPATGPSAGTAGQ------------------------------------------------------------ ------------------QDAERLALPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LQMNK IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPGQKEAHA-------------QA-GVQVKQEPIESDDEE AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP LSRAQSSPASAT---FPVSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS ---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELK--------------- -------------------------------------------------------------------------------- ------------------------------------TVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS MEKVMEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRCLQRTTSTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-PDEE PMEEEPPL--------------------------------------------------------------- >Gorilla_gorilla-HDAC4(ENSGGOP_26804) ---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSGPSSPN---------NSSGSVSAENGIAPTVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN ITLG---LPATGPSAGTAGQ------------------------------------------------------------ ------------------QDAERLALPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LQMNK IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPGQKEAHA-------------PA-GVQVKQEPIESDDEE AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP LSRAQSSPASAT---FPVSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS ---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVTTG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAVAAKLLQQRLS----VSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--G??P QVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS MEKVMEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRCLQRTASTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-PDEE PMEEEPPL--------------------------------------------------------------- >Callithrix_jacchus-HDAC4(ENSCJAP_51829) ---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCLSS-DPRYWYGKTQHSSLDQSSPPQS---GVSA SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSGPSSPN---------NSSGNVSAENGISPAVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN ITLG---LPATGPSAGAAGQ------------------------------------------------------------ ------------------QDAERLALPTLQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHMNK IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPG-KEAHP-------------QG-GVQVKQEPIESDDEE AEPPQEVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP LSRAQSSPASAT---FPVSVQ--EPPAKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS ---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPLGHHAE ESTPMG-FCYFNSVAVAAKLLQQRLS----VSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GAPD EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS MEKVMEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRCLQRAASTAGRSLIEAQTCE-----NDEAETVT-AMASLSVG-VKPA-------EKR-PDEE PMEEEPPL--------------------------------------------------------------- >Pongo_pygmaeus-HDAC4(ENSPPYP_14905) ---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSGPSSPN---------NSSGSVSAENGITPTVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN ITLG---LPATGPSAGTAGQ------------------------------------------------------------ ------------------QDAERLALPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHMNK IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPGQKEAHA-------------PA-GVQVKQEPIESDDEE AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP LSRAQSSPASAT---FPVSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS ---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTP-----------------------------------DVHHGNG-TQAFYSDPSVLYVSLHRYDDGNFP-----GSAD EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS MEKVMEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRCLQRATSTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-PDEE PMEEEPPL--------------------------------------------------------------- >Mus_musculus-HDAC4(ENSMUSP_8995) ---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA TALPLQVAPTA----------VPMDLRLDHQ------FSLP-LEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVSA SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVATALKK----RPLDVT---- ----DSACSSAPGSGPSSPN---------SSSGNVSTENGIAPTVPSAPAETSLAHRLVT--REGSVAPLPLYTSPSLPN ITLG---LPATGPAAGAAGQ------------------------------------------------------------ ------------------QDAERLALPALQQRI-----LFPGTHLTP-----------YLSTSPLERDG-----AAAHNP LLQHMVLLEQPPTQTPLVTG------------------------------LGALPLHSQSLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHLSK IISKPSEP--PRQPESHPEETEEELREHQALLDEPYL-DRLPGQKEPS--------------LA-GVQVKQEPIESEEEE AEATRETEPGQRPATEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDS- --------SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAVAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFFPGS--GAPD EVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F GYLTKQLMGLAGGRLV-LALEGGHDLTAICDASEACVSALLGNEL----------------EPLPEKVLHQRPNANAVHS MEKVMDIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRCLQRLSSTVGHSLIEAQKCE-----KEEAETVT-AMASLSVG-VKPA-------EKR-SEEE PMEEEPPL--------------------------------------------------------------- >Rattus_norvegicus-HDAC4(ENSRNOP_27622) ---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA TALPLQVAPAA----------VPMDLRLDHQ------FSLP-LEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCMSS-DPRYWYGKTQHSSLDQSSPPQS---GVSA SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVATALKK----RPLDVT---- ----DSACSSAPGSGPSSPN---------SSSGNVSTENGIAPTVPSTPAETSLAHRLVT--REGSVAPLPLYTSPSLPN ITLG---LPATGPAAGAAGQ------------------------------------------------------------ ------------------QDAERLALPALQQRIS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHNP LLQHMVLLEQPPTQTPLVTG------------------------------LGALPLHTQSLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHLSK MISKPSEP--PRQPESHPEETEEELREHQALLDEPYL-DRLPGQKEPS--------------LA-GVQVKQEPIESEEEE VEATREAEPSQRPATEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDS- --------SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFFPGS--GAPD EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------EPLPEKVLHQRPNANAVHS MEKVMGIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------EYWRCLQRLSPTVGHSLIEAQKCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-SEEE PMEEEPPL--------------------------------------------------------------- >Oryctolagus_cuniculus-HDAC4(ENSOCUP_1... -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------LAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAVAARLLQQRLN----VSKILIVDWDVHHGNGTQQAFYSDPSVLYVSLHRYDDGNFFPGS--GAPD EVGTGPGVGFNVNMAFTGGLDPPMGDTEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEV----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------- >Bos_taurus-HDAC4(ENSBTAP_23621) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------AS-VPPFLSRKTQHSSLDQSSPPQS---GASA SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSAPSSPN---------NSSGNVSTENGIAPAVPSIPAETSLAHRLVA--REGSVGPLPLYTSPSLPN ITLG---LPATGPSTGAAGQ------------------------------------------------------------ ------------------QEAERLALPALQQRIS----LFPGTHLAP-----------YLGAAPLERDA-----GAAPGS LLQHVVLLEQPPTQTPLVTG------------------------------LGALPLHAQPLVGAERV-----APSVHKLR QHRPLGRTQSAPLPQ--------STQALQHLVIQQQ--HQQFLEKHKQHFQ-QPQ--------------------LHLNK MIPKPSEP--ARQPESHPEETEEELREHQALLEEPFL-DRLPGQKEAHT-------------LA-GVQVKQEPIESDDEE TEPPREAEPGQRPPTEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP LSRAQSSPASAT---FPMSVQ--EPPAKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSETHALLYGTN--PLNRQKLDSK KLLG----SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLS----VSKTLVVDWDVHHGNGTQQAFYSDPRVLYISLHRYDDGNFFPGS--GAPD EVGTGAGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F GYLTKQLMGLAGGRVV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS MEKVIEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------QYWRSLQRLASTAGYSLVEAQKCE-----NEEAETVT-AMASLSVA-VKAP-------EKS-PSPR ARRGEPQP--------------------------------------------------------------- >Canis_familiaris-HDAC4(ENSCAFP_18541) -------------------------------------------RPGHPSQWCRGGRGRGSPCRCSDRRFCAVLSPTVDVA SALPLQVAPPA----------VPMDLRLDHQ------FALPVAEPT---LREQ-QLQQELLALKQKQQLQRQILIAEFQR QHEQLSRQHEAQLHEHIKAGQIKS-------MKVILRCPVATLK--QSRKAQAY---------RSKDSFHALHRRRE--G EQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVSA SYNHP-VLGMYDTKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSAPSSPN---------NSSGNVSAENGITPAVASIPAETGLAHRLVT--REGSVAPLPLYTSPSLPN ITLG---LPATGPSAGAAGQ------------------------------------------------------------ ------------------QDAERLALPALQQRIP----LFPGTHLTP-----------YLSTAPLERDG-----GAAHNP LLQHMVLLEQTPAQTPLVTG------------------------------LGALPLHAQPLVGADRV-----SPSMHKLR QHRPLGRTQSAPLPQ--------NAPALQHLVIIQASLKPQRAPEGLRAWR-TES--------------------RAAGR IIPKQNEP--ARQPESHPEETEEELREHQALLEEPYL-DRLSGQKEAHA-------------LA-GVQVKQEPIESDDEE AEPPREVEPGQRQPTEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP LSRAQSSPASAT---FPMSVQ--EPPTKPEVHHR----------------------------GLVYDTLMLKHQCTCGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLLG----SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLD----VSKTLIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GAPD EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS MEKVIEIHKR---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------QFWRYLPYLCYTVG-SLLDAQKCE-----NEEAADCHPPIVSLFEG-VKTA-------EKRRPDEE PMEEEPPL--------------------------------------------------------------- >Loxodonta_africana-HDAC4(ENSLAFP_9167) -------------------------------------------------------------------------PLTVDAV TALPLQVAPTA----------VPMDLRLDPP------FPLPVAEPA---LREQ-QLQQELLALKQKQQLQRQILIAEFQR QHEQLSRQHEAQLHEHVKQNE-------------KLTHEQTRCI--HQRNMRKG---------VEDRECSRGHGEAL--S LQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRS--LNHCISS-DPRYWYGKKKNSSLDQSSPPQS---GVSA SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSGPSSPN---------NSSSNVSSENGITPAVPSIPAETTLAHRLVA--R--EVTQLPLYTSPSLPN ITLG---LPATGPSAGAAGQ------------------------------------------------------------ ------------------QDAERLALPALQQRIP----LFPGTHLAP-----------YLSAAPLERDG-----GAAHNP LLQHLVLLEQPPPQTPLVAG------------------------------LGTLPLHAQSLVGADRV-----SPSVHKLR QHRPLGRTQSAPLPQ--------NTQALQHLVMVGL--QEQALHVSQVGLQ-EQA--------------------LHVSR IISKPSEP--TRQPESHPEETEEELREHQALLEEPCL-DRLPGQKGVHT-------------LA-GVQVKQEPVESDEEE TEAAREAEPGQRQATEQELLFRQPPPPHPSKPLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP LSRAQSSPASAT---FPMSVQ--EPPAKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RSQCECIRGRKATLEELQTVHSEAHALLYGTN--PLNRQKLDS- --------SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAVAAKLLQQRLS----VSRILIVDWDVHHGNGTQQAFYSDPSVLYISLHRYDDGNFFPGS--GAPD EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLTAF--RTVVMPVAVEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKTLQQRSNANAIRS MEKVIEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRSLQRTASTVGYSLVEAQKCE-----NEEAETVT-AMASLSVG-VKSA-------EKR-PDEE PMEEEPPL--------------------------------------------------------------- >Equus_caballus-HDAC4(ENSECAP_15097) ---------------------------------------------------------------------LCCALSAVDVA AALPLQVAPPA----------VPMDLRLDHQ------FSLPVTEPT---LREQ-QLQQELLALKQKQQLQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQEL----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVSA SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACSSAPGSAPSSPN---------NSSGNVSTENGIAPAVPSIPAETSLAHRLVT--REGSVAPLPLYTSPSLPN ITLG---LPATGPSAVSRHPR----------------------------------------------------------- -----------------VGEAERLALPALQQRIS----LFPGTHLTP-----------YLSTAPLERDG-----AAAHNP LLQHMVLLEQPPAQTPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQHLVVQQQ--HQQFLEKHKQQFQ-Q--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------- >Ornithorhynchus_anatinus-HDAC4(ENSOAN... ---------------------------------------------AASSSHPEGLFYVEIVVQSPDLAFVFAPPITVDVT TALPLQVAPSS----------VPMDLRLDHQ------FSMPGSEPT---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQ----------EMLAMKHQQELLE--HQRKLEQH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVSA TYNHP-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACNSAPGSGPSSPN---------NSSNNISNENGIAAQMTPAPQVTSLAHRLVN--REGSVTQLPLYTSPSLPN ITLG---LPATGPSSGGSGQ------------------------------------------------------------ ------------------QEAERLAIPTLQQRIS----LFPGTHLTP-----------YLSTTTLERDG-----GTAHNP LLQHMVLLEQPAAQTPLVTG------------------------------LGALPLHAQTLVGADRV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQQLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHINK MIPKANEP--SRQHESHPEETEEELREHQALLEEPYS-DRIPNQKEAQA-------------LASMVQVKQEPIESDEED TELPQEVEQGQRQ-AEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT ---NSHPEHAGRIQSVWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDS- --------SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GSPD EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLTAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRSNENAVHS MEKVIEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRSLQRFSSTVGYSLIEAQKCE-----NEEAETVT-AMASLSVG-VKQ--------AEKRPDEE PMEEEPPL--------------------------------------------------------------- >Gallus_gallus-HDAC4(ENSGALP_33098) -------------------------------------------------------------------------PSAVDVS TALPLQVAPTS----------VPMDLRLDHQ------FPMPVTEPT---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQ----------EMLAMKHQQELLE--HQRKLEQH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRFWYGKTQHSSLDQSSPPQS---GVSG TYNHP-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACNSAPGSGPSSPN---------NSSNNISAENGITGSVTSIQAETSLAHRLVN--REGSVTQLPLYTSPSLPN ITLG---LPATGPSSGGSAQ------------------------------------------------------------ ------------------QDAERLAIPALQQRIS----LFPGTHLTP-----------YLSTTTLERDG-----GTAHNP LLQHMVLLEQPTAQTPLVTDWY----------------------------LSGLPLHAQSLVGGERV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQQLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHINK IISKPNEP--ARQHESHPEETEEELREHQALLEEPYS-DRVSSQKEVPG-------------LANMVQVKQEPIESDEEE AEPQQELESGQRQ-AEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASLEAAGMPVSFGGHRP LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLLVV--GSISIIYSQHDCLGG-VNV-VDSDTIWNEVHSSGAARLAVGCVIELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GAPD EVGTGAGVGFNVNMAFTGGLDPPMGDTEYLTAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F GYLTKQLMGLAGGRVV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRANANAVHS MEKVIEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWHSLQRYASTVGYSLVEAQKCE-----NEEAETVT-AMASLSVG-VKP--------AEKRPDDE PMEEEPPL--------------------------------------------------------------- >Taeniopygia_guttata-HDAC4(ENSTGUP_3338) ----------------------------------------------FSPLFPDGLSGRDQPVELLNPPRVNHMPSSVDVS TALPLQVAPSS----------VPMDLRLDHQ------FSMPVTEPT---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQQ----------EMLAMKHQQELLE--HQRKLEQH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRFWYGKTQHSSLDQSSPPQS---GVSG TYNHP-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVTGTA- ----DSACNSAPGSGPSSPN---------NSSNNISTENGIAGSVTSIQAETSLAHRLVN--REGSVTQLPLYTSPSLPN ITLG---LPATGPSSAGQAQ------------------------------------------------------------ ------------------QDAERLAIPALQQRIS----LFPGTHLTP-----------YLSTTALERDG-----GTAHNP LLQHMVLLEQPTAQTPLVTDWY----------------------------LSGLPLHAQPLVGGERV-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQQLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHINK IISKPPEP--ARQHESHPEETEEELREHQALLEEPYG-ERATGQKEPPA-------------LASVVQVKQEPIESDEEE AEPQQELESGQRQ-AEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASLEAAGMPVSFGGHRP LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLL----GSLTSMFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVIELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GAPD EVGTGAGVGFNVNMAFTGGLDPPMGDTEYLTAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F GYLTKQLMGLAGGRVV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVFQQRANANAVHS MEKVIEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWHSLQRFASTVGYSLVEAQKCE-----NEEAETVT-AMASLSVG-VKP--------AEKRPEDE PMEEEPPL--------------------------------------------------------------- >Xenopus_tropicalis-HDAC4(ENSXETP_10592) ---------------------------------------------LNSQTSADGISGLDQPVDLLTQTRAKHMPSTVDVS AALPLQVAPSA----------LPMDLRLDPQ------YTISAQEPG---GREQ-QLQQELLALKQKQQIQRQLLIAEFQR QHEQLSRQHEAQLHEHIKQQQEL----------LAMKHQQELLE--HQRKLEQH---------RQEQEMEKQQREQK--L LQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRS--LNHCLSS-DPRLCHRKTQHSSLDQSPPPQG---VVSA SYHQA-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPGITTLKK----RPLDVS---- ----DSACNSAPGSGPSSPN---------NSSSNISSENGIAGPLG-IQTEASLAHRLAN--RENSVSQLPLYTSPSLPN ITLG---LPASGSTNGGSGQ------------------------------------------------------------ -------------------ENECLPLPALQQRLS----LFPAAHLTS-----------YLGP-----EA-----TSSHNQ LLQHMVLLEQPGAQSSLISG------------------------------LGTLPLHSQSLVSPDRV-----SPTMHKLR QHRPLGRTQSAPLPQ--------NSHALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHLNK MIPKVNEA--SRQHESHPEETEEELREHQALHEEPYA-ERLAEQKELSP-------------GS-VVHVKQEKEESDDED NTLELER---SKMQSDPDLLFRQ------QTLLLEQQRIHQLRNYQ-----------------ASLEAAGLVVPFSGHRP LSRAQSSPASAS---FPMSVQ--EAPSKPRFTT-----------------------------GLVYDTLMLKHQCICGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RSMCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLEGK TLPS----SLASLFVRLSCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELASKVVSG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKVLQQRLN----VEKTLIVDWDVHHGNGTQQAFYSDPNVLYISLHRYDDGNFFPGS--GAPD EVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAF--RTVVMPIAAKFSPDVVLVSA-GFDAVEGHPAPLGGYNVSAKC--F GYLTKQLMELAGGRVV-LALEGGHDLTAICDASEACVSALLGNKL----------------EPLPESVLQQRPNGNAARS MENVIQIQS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------EYWPCLHITSSTVAYSLIEAQKCE-----NEEAETVT-AMASLSVD-VRQ---------ERRTEDE PMDEEPPL--------------------------------------------------------------- >Anolis_carolinensis-HDAC4(ENSACAP_9498) ---------------------------------------------------------------------------AVDVT TTLPLQVAPTV----------VPMDLRLDHQ------FSIPVAEPT---LREQ-QLQQELLALKQKQQIQRQILIAEFQR QHEQLSRQHEAQLHEHIKQQ-----------EILAMKHQQELLE--HQRKLEQH---------RQEQELEKQHREQK--L QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAQRN--LNHCISN-DPRFWYGKTQHSSLDQSSPPQS---GVSG NYNHP-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT---- ----DSACNSAPGSGPSSPN---------NSSSNISAENGITPSVANIQAENNLAHRLAN--REGSVTQLPLYTSPSLPN ITLG---LPATAPSSGGSGQ------------------------------------------------------------ ------------------QDPERLALPSLQQRIS----IFPGTHIPP-----------YLSSTTVDRDG-----GNAHNP LLQHMVLLEQPSTQTPLVPG------------------------------LGALPLHAQSLVGADRL-----SPSIHKLR QHRPLGRTQSAPLPQ--------NAQALQQLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHINK MIPKPNES--SRQHESHPEETEEELREHQAFLEDPYI-DRISNQKDIQG-------------LTSMVQVKQEPVESDE-D GEFQPELEPGQRQ-AEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP LSRAQSSPASAN---FPISVQ--EPPCKPQFTT-----------------------------GLVYDTLMLKHQCTCGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RSKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK KLLG----SLTSVFVRLPCGG---VG-VDSDTIWNEVHSFSAARLAVGCVIELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAISAKLLQQRLN----VNKILIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GAPD EVGIGPGAGFNVNMAFTGGLDPPMGDTEYMAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPAPLGGYNLSAKC--F GYLTKQLMGLAGGRII-LALEGGHDLTAICDASETCVSVLLGNEL----------------DPIPEKVLQQRPNANAVHS IEKVIEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWHSLQRYASTVSYSLTEAQKCE-----NEEAETVT-AMASLSVG-VKPP-------PDKKPDEE PMEEDPPL--------------------------------------------------------------- >Danio_rerio-HDAC4(ENSDARP_107448) --------------------------------------------------------------------------TVDVS- VALPLQVPPSA----------IPMDLRVDHQ------FALAPTDPA-QREHQ---LQQELLALKQKQQIQRQLLIEEFQR QHEQLSRQHEAQLQEHVKHQQ----------DLLALKHQQELLE--HQRKLERH---------RQEQEMEKQQREQK--L QLLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNHCLPS-DPRYWYGKTQHSSLDQSSPPQT---GIS- TYNHP-VLGMYDPKDDFPLRKTASASEPNLKLRSRLKQKVSERRS----SPLLRRKDGP-ITTAKK----RSLDMA---- ----ESACSSAPGSGPSSPN---------NSSNNITNENGIAGSISNSAVEPSLAHRLTG--REGPVSQLSLYTSPSLPN ITLG---LPATGPSS-VASGQ----------------------------------------------------------- -----------------QDGD-RMAVPGLQPGIPITTPFMPGAHLPS-----------YLAASSLERE-----SGSAHNT LLQHMVLLEQSAAQNS-------------------------------------LVAGLSG--VPLQS-----HSIHKLRQ -HRPLGRTQSAPLPQ----N----SQALQQLVVQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHISK MMVKPSEP--NRQHESHPEETEEELREHQGLGDPADP-------------------------LPHGVTIKQEPPDEQD-- -EDFQQ----RERQAEEELLFRQ-----N-SLLLEQQRIHQLRNYQ-----------------ASMEAAGLSVSFPVHRP LSRAQSSPASAT---FPIVVQ--EPPAKPRFTT-----------------------------GLVYDTLMQKHQCMCGNS ---NIHPEHAGRIQSIWSRLQETGL-----------RGQCECIRGRKATLEELQTVHSEAHVLLYGTN--PL-RQKLD-- ---S----SVTPMFVRLPCGG---IGVVDSDTIWNEVHSSSAARLAVGSVVDLVFKVASG--ELRNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYSDPNVLYLSLHRYDDGNFFPGS--GAPD EVGIGPGVGFNVNMAFTGGLEPPMGDADYLAAF--RSVVMPIANEFSPDVVLVSS-GFDAVEGHPPPLGGYKLTAKC--F GYLTKQLMGLAGGRLV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPIPEDILQQRPNANAIQS MEKVLEVQS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRSLQRSVSTLGYSLREAQRCE-----NEEAETVT-AMASLSVAN-KHM-------GK-RPEEE PMEEEPPL--------------------------------------------------------------- >Oryzias_latipes-HDAC4(ENSORLP_22663) ---------------------------------------------------------------LKAKRLYRLSCLVDVSP AALPSQVPPTSTA-------ILPMDLRVVDH------HHKKKQTPP-GHQEH--QLQHELVALKHKQQLQRQLLIAEFQR QHEQLSRQHEAQLQEHIKHQQ----------DLLALKHQQELLE--HHRKMEQQ---------RHDQ-LEKQQREQK--L QQLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRN--LNHCLPS-DLRYWYGKTHHSSLDQSSPPQT---ALS- AYNHP-MLGTYDLKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGL-ITTAKK----RSLDVA---- ----EPACNSAPGSGPSSPN---------NSSSNIPNENGIP--ISSSHGEASLLQRLAA--REGSVSQLSLYTSPSLPN ITLG---LPATGPASAVVSGH----------------------------------------------------------- -----------------QDGESHLALPALQQGIPLTPPFLPTAHLPS-----------YLAPSALDREGPGGGTAG-HNP LLQHVVLLEQGHSPMEKHVQG-----------------------------ALCHTVGLAG--LPLPS-----PTVSKLVR GHRPLGRTQSAPLPQ----QPCGQAQALQQLVVQQQ--HQQFLEKHKQLFQQQQQHLISKIMSKP---------GDPASA VGSSASLP--GRQHQSHPEETEEELREHQGLSSSSS--SPSSAPMQETR-------------LLR--AIKQEPPDPEE-- QEEREQ----RERHSEPDFLFKQ-----QQTLLLEQQRIHQLRNYR-----------------ATIEDSSLPGTLAGKRP LFRTQSSPASAS---LPMAVQ--ESPVKHRFTT-----------------------------GLVYDSLMQKHQCICGNS ---TIHPEHAGRIQSIWSRLQETGL-----------RAHCEVIRGRKASPEELQTVHSEAHVQLYGTN--PL-RQRLDCK TCIS----SVNPVFVRLPCGG---IG-VDSDTIWNEVHSSSAARLAVGSVVELVFKVASG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYADPNVLYLSLHRYDDGNFFPGS--GAPD EVGSGAGVGFNVNVAFTGGLEPPMADAEYLAAF--RTVVMPIAKEFAPDMVLVSS-GFDAVDGHAPPLGGYKVTSKC--F GYLTRQLMDLAGGRLV-LALEGGHDLTAICDASEACISALLGNEL----------------EPIPEEVLQQRPNANAVSS LEKVMETHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRSLQRSASTLCCSLSEALQHD-----VEEAETVS-AMASLSVAN-KHI-------GK-RAEEE PMEEEAAM--------------------------------------------------------------- >Takifugu_rubripes-HDAC4(ENSTRUP_35900) ---------------------------------------------ECALSSTEGILGKEQPLEVLKTSVLNHIPTVDIN- SALPLRLPPAA----------IPMDLRVDPH------QQQQQVSQ--PSVCDQ-QLQQELLTLKQKQQIQRQILIAEFQR QHEQLSRQHEAQLQEHIKQQQ----------ELLALKHQQELLE--HQRKMENH---------RMEQELEKQQREQK--L QLLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNQGGPHNDAPYWYRKTQHSSLDQSSPPQT---GVS- TYNQP-VLGVYNPRDDFPLRKTAS--EPNLKLRSRLKQKVSERRS----SPLLRRRDSP-ITTAKK----RSLDMA---- ----DSACSSAPGSGPSSPN---------NSSNNIPSENGVTVSVSNNS-EVSLAQRMCGGAERGSVNQLSLYTSPSLPN ITLG---LPATATATAASNVT----------------------------------------------------------- ---------------------SAQPDGGLQPALSLSPPFLSGGHLTP-----------YLAEAGAGTGG-----HAAHSP LLQHMVLMEQSPAQSPLVTGTL----------------------------RLPSHSKTSIHLSKL-------MSSFHMQR QHRPLGRTQSAPLPQGSAAQAHAQALALQQLVVQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHLNK MITKPSESPVGRQHQSHPEETEEELREHQDGGALPAG-----------------------------VTIKQEPPDPQELQ EEVLHRE---RERQAEQQELLFR-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLSISFPGHRP LSRAQSSPASASS--FPISVPASDPPTKPHFTT-----------------------------GLVYDSLMQKHQCMCGNT ---NNHPEHAGRIQSIWSRLQETGL-----------RAQCECIRGRKATLEELQTVHSEAHVLLYGTN--PL-RQKLDCR LLPG----SITPMFVRLPCGG---IG-VDSDTIWNEVHSSSAARLAVGSVVELVFKVATQ--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLN----INKILIVDWDVHHGNGTQQAFYDDPSVLYLSIHRYDDGNFFPGS--GAPD EVGSGPGVGFNVNVAFTGGLEPPMSDAEYLAAF--RSVVMPIANEFAPDIVLVSS-GFDAVEGHPPPLGGYTLTAKC--F GYLTRQLMTLAGGRLV-LALEGGHDLTAICDASEACLAALLGQEL----------------DPLPKSVLEQRPNVNAVRS LEKVLEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRSVQRYSLHLGLSLLEAKRGD-----SEEAEAVS-AMASLSVANTNAM-------DQSRSEEE PMEEEEPL--------------------------------------------------------------- >Takifugu_rubripes-HDAC4(ENSTRUP_12899) ----------------------------------------------------------------------LSHFPVDVSA AALPMQVPPAATA-------ILPMDLRVDHH------HNHQQQPTF-DHQEQ--QLQQELVALKHKQQLQRQLLIAEFQR QHEQLSRQHEIQLQEHIKHQQ----------DLLALKHQQELLE--HQRKIEQQ---------RHEQELEKQQREYK--L HQLKNKDRGQES---AIASTEVKMRLQEFVLNKKKALAQRN--LNHCLPS-DPRYWYGKTQHSSLDQSSPPQT---ALS- AYTHP-MLGTYDSKDDFPLRKTAS--EPNLKLRSRLKQKVTERRS----SPLLRRKDGP-IPSAKK----RSLDVA---- ----DSACNSAPGSGPSSPN---------NSSSNIPSENGIT--ISSSPGEASLLQRLAA--REGSVSHLSLYTSPSLPN ITLG---LPATGPAASVVSGH----------------------------------------------------------- -----------------KDGDSRLTLPALQQGIPLTSPFLPPTHLPS-----------YLTSSALDREAPGGGAAGAHNP LLQHMVLLEQGHSPMVLTCLLF----------------------------GPFHNKSLGG--LPLQS-----PSVSKLAR GHRPLGRTQSAPLPQ----QQCGQAQALQQLVVQQQ--HQQFLEKHKQQFQ-QQQHIISKIMSKP---------TDQVSA VSSSPSGP--ARQHQSHPEETEEELREHQGLPSSSSPPTPSSLPVKEAG-------------PMRSVVIKQEPVDPQE-- VEEKEQ----RERQAEKDFLFRQ-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLPVSFAGHRP LSRAQSSPASAS---FPIVVP--ESTTKPRFTT-----------------------------GLVYDSLMQKHQCMCGNT ---TIHPEHAGRIQSIWSRLQETGL-----------RAHCECIRGRKASLEELQTIHSEAHVLLYGTN--PL-RQKLDCK ISLS----SVSPMFVRLPCGG---IG-VDSDTIWNEVHSSTAARLAVGSVAELVFKVASG--ELKNG-FAVVRPPGHHAE ESAPMG-FCYFNSVAIAAKLLQQRLS----VRKILIVDWDVHHGNGTQQAFYADPGILYISLHRYDDGNFFPGS--GAPD EVGSGAGVGFNVNMAFTGGLEPPMGDVEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVDGHASPLGGYKLTAKC--F GYLTRQLMGLAGGRVV-LALEGGHDLTAICDASEACVSALLGNEL----------------EPIPDKLMQQRPNANAVRS MEKVLEAHG----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWCSLQRSASTLGCSLSEALQRD-----TEEAETVS-AMASLSVAN-KHM-------GK-RSEEE PMEEETS---------------------------------------------------------------- >Tetraodon_nigroviridis-HDAC4(ENSTNIP_... ---------------------------------------------ECALSSTEGILGKEQPLEVLKTSVLNHIPTVDIN- SALPLRLPPAA----------IPMDLRVDPQ------QQQQAGGGGGPSVCDQ-QLQQELLTLKQKQQIQRQILIAEFQR QHEQLSRQHEAQLQEHIKQQQ----------ELLALKHQQELLE--HQRKMENH---------RMEQELEKQQREQK--L QLLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNQGGPHNDAP--YCKTQHSSLDQSSPPQT---GVS- TYNQP-VLGVYNPRDDFPLRKTAS--EPNLKLRSRLKQKVSERRS----SPLLRRRDSP-ITTAKK----RSLDMA---- ----DSACSSAPGSGPSSPN---------NSSNNIPSENGVAVSVSNNT-EVSLAQRMCTGAERGSANQLSLYTSPSLPN ITLG---LPATATATAASNVT----------------------------------------------------------- ---------------------SAQTDGGLQPALSLSPPFLSGSHLTP-----------YLAEAGAGTGG-----HPAHSP LLQHMVLMEQSPAQSPLVTGRS----------------------------FSNMQNDSSISGSSFGA-----ASMAKLQR QHRPLGRTQSAPLPQGSAAQAHAQALALQQLVAMAT--ER----KPQPFMV-RQT--------------------LHIFQ MMTKPSESPMGRQHQSHPEETEEELREHQDGGALPAG-----------------------------VTIKQEPPDPQELQ EEALHRE---RERQAEQQELLFR-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLSISFPGHRP LSRAQSSPASASS--FPISVPASEPPTKPRFTT-----------------------------GLVYDSLMQKHQCMCGNT ---NNHPEHAGRIQSIWSRLQETGL-----------RAQCECIRGRKATLEELQTVHSEAHVLLYGTN--PL-RQKLDC- --------SITPMFVRLPCGG---IG-VDSDTIWNEVHSSSAARLAVGSVAELVFKVATR--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLN----INKILIVDWDVHHGNGTQQAFYDDPSVLYLSIHRYDDGNFFPGS--GAPD EVGSGPGVGFNVNVAFTGGLEPPMGDAEYLAAF--RSVVMPIANEFAPDIVLVSS-GFDAVEGHPPPLGGYTLTAKC--F GYLTRQLMTLAGGRLV-LALEGGHDLTAICDASEACLAALLGQEL----------------DPLPKSVLEQRPNANAVRS LEKVLEIHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRSVQRYSLHLGLSLLEAKRGD-----SEEAEAVS-AMASLSVANTNAI-------DQSRSEEE PMEEEEPL--------------------------------------------------------------- >Tetraodon_nigroviridis-HDAC4(ENSTNIP_(2) ---------------------------------------------VGAQIHPDGVPVCREAPCLKLSQARLPHLAVDVST AALPMQVPPAATA-------ILPMDLRVDHH------HNHQQQP---NHQEQ--QLQQELVALKHKQQLQRQLLIAEFQR QHEQLSRQHEIQLQEHIKHQQ----------DLLALKHQQELLE--HQRKIEQQ---------RHEQELEKQQREYK--L HQLKNKDRGQES---AIASTEVKMRLQEFVLNKKKALAQRN--LNHCLPT-DPRYWYGKTQHSSLDQSSPPQT---ALS- AYTHP-MLGTYDAKDDFPLRKTAS--EPNLKLRSRLKQKVTERRS----SPLLRRKDGP-TTTAKK----RSLDMA---- ----DSACNSAPGSGPSSPN---------NSSSNIPSENGVT--ISSSPAEASLLQRLVA--REGSVSHLSLYTSPSLPN ITLG---LPATGPAASVVSGH----------------------------------------------------------- -----------------QDGDGRLALPALQQGIPLTSPFLPHTHLPS-----------YLTPSPLDREGPGGAAAGSHNP LLQHMVLLEQGHS--------------------------------------PVATPGLGG--LPLPS-----PSVSKLAR GHRPLGRTQSAPLPQ----QQCGQAQALQQLVVQQQ--HQQFLEKHHQQDF-RQN-------------------AKQVSA VSSSPSGP--ARQHQSHPEETEEELREHQGLSSSSS--SSPSVSVKEAG-------------PIRGVVIKQEPVDPQE-- LEEKEQ----RERQAEKDFLFRQ-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLPVSFAGHRP LSRAQSSPASAS---FPIVVP--EPSTKLRFTT-----------------------------GLVYDSLMQKHQCMCGNT ---TVHPEHAGRIQSIWSRLQETGL-----------RAHCECIRGRKASLEELQTVHSEAHVLLYGTN--PL-RQKHDSR LLKC----SVSPMFVMLPCGG---IG-VDSDTIWNEVHSSTAARLAVGSVAELVFKVASG--ELKNG-FAVVRPPGHHAE ESAPMG-FCYFNSVAIAAKLLQQRLN----VRKILIVDWDVHHGNGTQQAFYADPGILYISLHRYDDGNFFPGS--GAPD EVGSGPGAGFNVNMAFTGGLEPPMGDVEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVDGHASPLGGYKLTAKC--F GYLTRQLMALAEGRLV-LALEGGHDLTAICDASEACVSALLGNEL----------------EPIPDEVMRQRPNANAVRS MEKVVGAHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRSLQRSASTLACSLSERLQRD-----TEEAETVS-AMASLSVAN-KHM-------GK-RCEEE PMEEEAS---------------------------------------------------------------- >Gasterosteus_aculeatus-HDAC4(ENSGACP_... --------------------------------------------------------------------------SVDVSS AALPMQVPPTTTA-------ILPMDLRVVTG------GAEALTCRS-RPTDQP-ELQQELVTLKHKQQLQRQLLIAEFQR QHEQLSRQHEVQLQEHVKHQQ----------DLLALKHQQELLE--HQRKMEQQ---------HLEQEMEKQQREHK--L LQLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNHRLPS-DPRFWYGKTQHSSLDQSSPPQT---ALS- AYTHP-MLGTYDSKDDFPLRKTAS--EPNLKLRSRLKQKVTERRS----SPLLRRKDGP-ITTAKK----RSLDVA---- ----ESACNSAPGSGPSSPN---------NSSSNIPCENGVN--ISCSPGEASLLQRLAA--REGSVSQLSLYTSPSLPN ITLG---LPATGQASSVGSVH----------------------------------------------------------- -----------------QDGESRLALPALQQGIPLTRPFLPTAHLPS-----------YLASSALDREGGGGGVAG-HNP LLQHMVLMEQSHNSMG-------------------------------------LFFGLAG--LPLPS-----PSVSKLAR GHRPLGRTQSAPLPQ----QQCGQAQALQQLVVQQQ--HQQFLEKHKQQFQ-QQQ--------------------HIINK ASSSASGP--ARQHQSHPEETEEELREHQGLSLSSLS-ASCSASAQDTG-------------PLRGLVIKQEPSDPQEQQ QEEREK----MERLVEQDFLFRQ-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLSVSFAGHRP LSRAQSSPASAS---FPMVVQ--EPPTKPRFTT-----------------------------GLVYDSLMQKHQCMCGNT ---TSHPEHAGRIQSIWSRLQETGL-----------RSHCECIRGRKASLEELQTVHSEAHVLLYGTN--PL-RQKLD-- ---C----SVSPMFVRLPCGG---IG-VDNDTIWNEVHSSSAARLAVGSVVELVFKVASG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKVLIVDWDVHHGNGTQQAFYADPNVLYLSLHRYDDGNFFPGS--GAPD EVGSGAGVGFNVNMAFTGGLEPPMSDAEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVDGHAPPLGGYKLTAKC--F GYLTRQLMGLAGGRLV-LALEGGHDLTAICDASEACVSSLLGNEL----------------DPIPEEVLQQIPNANAVRS MEKVLEIHN----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWRSLQRSASTLGCSLSEALRRD-----AEEAETVS-AMASLSVAN-KLV-------GK-RAEEE PMEEEATM--------------------------------------------------------------- >Gasterosteus_aculeatus-HDAC4(ENSGACP_(2) ---------------------------------------------CGVILYPCAVNQKQSPTLCLPPPHL----AVDIN- SALPLRLPPAA----------IPMDLRVGPR------SPRPVSSR---PGRVW-KIAASIIGATDQQQPTTNMIEVSLRQ KFERIAGSLETLLWCFFPQQQQ---------ELLALKHQQELLE--HQRKMENH---------RLEQELEKQQREQK--L LLLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNQGGLHNDAPYWYRKTQHSSLDQSSPPQT---GVS- TYNHP-VLGVYNPRDDFPLRKTAS--EPNLKLRSRLKQKVSERRS----SPLLRRRDSP-ITSAKK----RSLDMA---- ----DSACSSAPGSGPSSPN---------NSSNNIPNENGITASVANNT-EASLAQRLCG-AERGSVNQLSLYTSPSLPN ITLG---LPATATSTAASNQ------------------------------------------------------------ -------------------------EGGLQPALSLSPPFLSGGHLTP-----------YLAEAGAGTGG-----HGAHSP LLQHMVLMEQSPAQSPLVTGSL----------------------------PVFMSKGVSG-LSMSPA-----ASMAKLQR QHRPLGRTQSAPLPQGSAAQAHAQALALQQ---------------------------------------------LHLNK MMTKPGESPGGRQHQSHPEETEEELREHQDGGALPPG-----------------------------VTIKQEPPDPQELQ EEALQQH---RERQAEQ-ELLFR-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLSLSFPAHRP LSRAQSSPASASS--FPISVPPPDPSAKPRFTT-----------------------------GLVYDSLMQKHQCMCGNT ---NSHPEHAGRIQSIWSRLQETGL-----------RAQCECIRGRKASLEELQTVHSEAHVLLYGTN--PL-RQKLDCK ---C----SVTPMFVRLPCGG---LG-VDSDTIWNEVHSSSAARLAVGSVVELVFKVATG--ELKNG-FAVVRPPGHHAE ESTPMG-FCYFNSVAIAAKLLQQRLS----VNKILIVDWDVHHGNGTQQAFYDDPNVLYLSIHRYDDGNFFPGS--GAPD EVGSGPGVGFNVNVAFTGGLDPPMGDVEYLAAFRLRSVVMPIANEYCPGTSCWSPPGLDGVEGHPP-LSGYTLTSKC--F GYLTRQLMTLAGSRVV-LALEGGHDLTAICDASEACVAALLGQEL----------------DPLPKAVLEQRPNPNAVRS LEKVLETHS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KYWGSLHRCSPLLGLSLLEAKRGD-----SEEAEAVS-AMASLSVANCNAM-------DQ-RPEEE PMEEEEPL--------------------------------------------------------------- >Homo_sapiens-HDAC5(ENSP_337290) -------------------------------------------MNSPNE-SDGMSGREPSLE-ILPRTSLHSIPVTVEVK PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTLREQ-QLQQELLALKQQQQLQKQLLFAEFQK QHDHLTRQHEVQLQKHLKQQQEMLAAK-QQQEMLAAKRQQELEQ---QRQREQQ----------RQEELEKQRLEQQ--L LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP --GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN ISLG---LQATVTVTNSHLTASPK-------------------------------------------------------- --------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP RHRPLSRTQSSPLPQS--------PQALQQLVMQQQ--HQQFLEKQKQQ--QLQLG-----------------------K ILTKTGELP--RQPTTHPEETEEELTEQQEVL-LGEGALTMPREG-----------------STESESTQEDLEEEDEED DGEEEE---DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPL---------------QPLQVYQAPLSLATVPHQA LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTT----------------------------------------------- -------------------------------------------------------------------------------- ---G---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F GHLTRQLMTLAGGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT LEKVIEIQS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQA-QAAAAREHSPRPAEE PMEQEPAL--------------------------------------------------------------- >Macaca_mulatta-HDAC5(ENSMMUP_8946) -------------------------------------------MNSPNE-SDGMSGREPSLE-ILPRTSLHSIPVTVEVK PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTLREQ-QLQQELLALKQQQQLQKQLLFAEFQK QHDHLTRQHEVQLQKHLKQQQEMLAAK-QQQEMLAAKRQQELEQ---QRQREQQ----------RQEELEKQRLEQQ--L LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP --GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN ISLG---LQATVTVTNSHLTASPK-------------------------------------------------------- --------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP RHRPLSRTQSSPLPQS--------PQALQQLVMQQQ--HQQFLEKQKQQ--QLQLG-----------------------K ILTKTGELP--RQPTTHPEETEEELTEQQEAL-LGEGALTMPREG-----------------STESESTQEDLEEEEEEE DGEEEE---DCIQVKDEEGESGAEEGPDSEEPGAGYKKLFSDAQPL---------------QPLQVYQAPLSLATVPHQA LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTT----------------------------------------------- -------------------------------------------------------------------------------- ---G---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F GHLTRQLMTLAGGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT LEKVIEIQS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQA-QAAAAREHSPRPAEE PMEQEPAL--------------------------------------------------------------- >Pan_troglodytes-HDAC5(ENSPTRP_15756) RHGGPGLPSRPSVCYRLSLLTSPQLHPLPSQPPTPASCRPRAGMNSPNESADGMSGREPSLE-ILPRTSLHSIPVTVEVK PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTLREQ-QLQQELLALKQQQQLQKQLLFAEFQK QHDHLTRQHEVQLQKHLKQQQEMLAAK-QQQEMLAAKRQQELEQ---QRQREQQ----------RQEELEKQRLEQQ--L LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP --GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN ISLG---LQATVTVTNSHLTASPK-------------------------------------------------------- --------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP RHRPLSRTQSSPLPQS--------PQALQQLVMQQQ--HQQFLEKQKQQ--QLQLG-----------------------K ILTKTGELP--RQPTTHPEETEEELTEQQEVL-LGEGALTMPREG-----------------STESESTQEDLEEEDEEE DGEEEE---DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPL---------------QPLQVYQAPLSLATVPHQA LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTTG----------------------------VVYDTF-MLKHQCMCGNT ---HVHPEHAGRIQSIWSRLQETGL-----------LSKCERIRGRKATLDEIQTVHSEYHTLLYGTS--PLNRQKLDSK KLLG---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F GHLTRQLMTLAGGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT LEKVIEIQS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQA-QAAAAREHSPRPAEE PMEQEPAL--------------------------------------------------------------- >Gorilla_gorilla-HDAC5(ENSGGOP_19129) ----------------------------------------------SPLNAGGWSGERPAYEPVLPKTRVLSLLPAVEVK PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTL-----------------------LFAEFQK QHDHLTRQHEVQLQKHLK-----------PPRPPTPARAWLTCA---SVPMPLQ----------QQQEML?QEMLAA--L LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP --GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN ISLG---LQATVTVTNSHLTASPK-------------------------------------------------------- --------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP RHRPLSRTQSSPLPQS--------PQARQVLFSEEL--PRLFLTHIEALPGRREGG-----------------------K ILTKTGELP--RQPTTHPEETEEELTEQQEAL-LGEGALTMPREG-----------------STESESTQEDH------- ----------CIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPL---------------QPLQVYQAPLSLATVPHQA LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTTG----------------------------EPPPTVRKLPQAGLWGDT ---DVP--EGGPVSPVESKTQGFGR-----------RGKAEGAVRR-VQLRRHSWQRSDSCECPGGVK----RGQRLEIL FRAG---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F GHLTRQLMTLAGGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT LEKVIEIQS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQA-QAAAAREHSPRPAEE PMEQEPAL--------------------------------------------------------------- >Callithrix_jacchus-HDAC5(ENSCJAP_18977) --------------------------------------------TESCFSADGMSGREPSLE-ILPRTSLHSIPVTVEVK PVLPGAMPSSMGGGGGG--SHSPVELRG------------ALVGSVDPTL-----------------------LFAEFQK QHDHLTRQHEVQLQKHLK-----------QQQE-------MLAA---KQQQEML----------AAEELEKQRLEQQ--L LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP --GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN ISLG---LQATVTVTNSHLTASPK-------------------------------------------------------- --------------LSTQQEAERQALQSLRQGGMLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP RHRPLSRTQSSPLPQS--------PQARQALLSEEP--PGLFLTHVEALPGRSEGG-----------------------K ILTKTGELP--RQPTTHPEETEEELTEQQEAL-LGEGALTMPREG-----------------STESESTQEDH------- ----------CIQVKDEEGESGAEEGPNSEEPSAGYKKLFSDAQQL---------------QPLQVYQAPLSLATVPHQA LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTTG----------------------------VVYDTF-MLKHQCMCGNT ---HVHPEHAGRIQSIWSRLQETGL-----------LSKCERIRGRKATLEEIQAVHSEYHTLLYGTS--PLNRQKLDSK KLLG---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F GHLTRQLMTLAEGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT LEKVIEIQS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQV-QAAAAREHSPRPAEE PMEQEPAL--------------------------------------------------------------- >Pongo_pygmaeus-HDAC5(ENSPPYP_9379) -------------------------------------------MNSPNESADGMSGREPSLE-ILPRTSLHSIPVTVEVK PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTLREQ-QLQQELLALK-HQQLQKQLLFAEFQK QHDHLR-QHEVQLQKHLQQQ-----------EMLAAKRQQELEQ---QRQREQQ----------RQEELENLRLEQQ--L LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP --GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN ISLG---LQATVTVTNSHLTASPK-------------------------------------------------------- --------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP RHRPLSRTQSSPLPQS--------PQALQQLVMQQQ--HQQFLEKQKQQ--QLQLG-----------------------K ILTKTGELP--RQPTTHPEETEEELTEQQEAL-LGE