>Homo_sapien_NSD1 ------------------------------------------------------------------MDQTCELPRRNCLL PFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-GTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADG SESFQDPEKSDSRAQTPIVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQEPSCNNSPELQVKVTKTIKNGFLHFE NFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTE TQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPG---TSSSSTSQELPFCQ PKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHK------------------ ------DERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKN-----TAKKEFETSNGDSLL GLPEGALISKCSREKNKPQ------------------------------------------------------------- ---RSLVCGSK-VKLCYIG------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPIEHSSESDNSVLEIPDAFDRTENMLSM----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPG-TETSQVNLSDLKASTLVHKPQSD FTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKS-KQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTK---G SPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPS G-GDSALSGELSASLPGLLSDKRD---LPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLN QLPSVTLDAVLQGDRERG----GSLRGGAEDPSKEDPLQIMGHLTSEDG-DHFSDVHFDSKVKQSDPGKISEKGLSFEN- --GKGPELDSVMNSEN---DELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEH RTP-SASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSS--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPA-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGG--GTTKIFDK-----------------------PRKRK RQRHAAAKMQCKKVKNDDSSKEIPG-SEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICITCHAAN------PANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLPPGPSTHLAEQ-STGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLP-ERPLERTDSRPQPLDK--- --VRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPS-PVTSPSSSPSVRS--------QPLERPLGTADPR---L DKSIGAASPRPQSLEKTSV-------------PTGLRLPPPDRL------------------------------------ ------------------------------------------------------LITSSPKPQTSDRPTD---------- ------------------------------------------------------------------------KPHASLSQ RLPPPEKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPV LESSSWPASKGLG----HMPRAVEK-GCVSDP-LQTSGKAAAPS-EDPWQAVKSLTQARLLSQPPAK-AFLYEPTTQASG RASAGAEQTPGPLSQSPGLVKQAKQ----MVGGQQLPALAAKSG----QSFRSLGKAPASLPTEEK-----KLVTTEQSP WALG--KASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGR-----GQD--PKPEQNTLPALNQAPSSHKCAESEQ K >Mus_musculus_NSD1 ------------------------------------------------------------------MDRTCELSRRNCLL SFSNPVNLDASEDKDSPFGNGQSNFSEPLNGCTMQLPTAASGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLSGSADG SESFQDPAKSDSRAQSPIVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQEPTCNNSPELQLRVTKTTKNGFLHFE NFTGVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYEPKSENGVEVAMGSEQDSMPESRHGAVERPFLPLAPQTE KQKNKQRSEVDGSNEKTALLPAPTSLGDTNVTVEEQFNSINLSFQDDPDSSPSPLGNMLEIPG---TSSPSTSQELPFCQ PKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VANRRPY-----REYYVEAFGDPSEKAWVAGKAIV MFEGRHQFEEL---PVLRKRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNQKCVSSSVKLDSEEDMPFEDCT ND-PDSEH-LLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSSDNIKRTSVKKDLVPFESRK------------------ ------EERRGKIPDNLGLDFISGGVSDKQASNELSRIANSLTGSSTAPGSFLFSSSVQN-----TAKTDFETPDCDSLS GLSESALISKHSGEKKKLQ------------------------------------------------------------- ---PGQVCSSK-VQLCYVG------------------------------------------------------------- --------------AGDEEKRSNSVSVSTTSDDGCSD--LDPTEHNSGFQNSVLGITDAFDKTENALSV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------HKN-ETQYSRYPVTN-RIKEKQKSLITNSHADHLMGSTKTMEPETAELSQVNLSDLKISSPIPKPQPE FRNDGLTTKFSAPPGIRNENPLTKGGLANQTLLPLKC-RQPKFRSIKCKHKESPAVAETSATSEDLSLKCCSSDTN---G SPLANISKSGKGEGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTAKASKPLLFSSASSQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLASYRTPDRGDCSSGSPVGTSKVLVLGSSTPNSEKPGDSTQDSVHQSPG G-GDSALSGELSSSLSSLASDKRE---LPACGKIRSNCIPRRNCGRAKPSSKLRETISAQMVKPSVNPKALKTERKRKFS RLPAVTLAANRLGNKESG-SVNGPSRGGAEDPGKEEPLQQMDLLRNEDT--HFSDVHFDSKAKQSDPDKNLEKEPSFEN- --RKGPELGSEMNTEN---DELHGVNQVVPKKRWQRLNQRRPKPGKRANRFREKENSEGAFGVLLPADAVQKAREDYLEQ RAP-PTSKPEDSAADPNHGSHSESVAPRLNVCEKSSVGMGDVEKETGIPSLMPQTKLPEPAIRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEDESLLARCQPS--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSDLG------VTHAELPQLTLSVPV-APEASPRPA-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSRKCFEASRSGNGIVESRATSHLKEFSG--GTTKIFDK-----------------------PRKRK RQRLVTARVHYKKVKKEDLTKDTPS-SEGELLIHRTAASPKEILEEGVEHDPGMSASKKLQVERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLPEMPRGKFICNECHTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVTQNKG-FRCPLHICITCHAAN------PANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQ YPDVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIVTEEKSRKFKRKPHGKRRSQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDV--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPTATSPPSPGTQPKEQ-SSEMATQGPKKSDQPPTDATQLLPLSKKALTGSCQRPLLP-ERPPERTDSSSHLLDR--- --IRDLAGSGTKSQSLVSSQRPQDRPPAKEGPRPQPPDRAS-PMTRPSSSPSVSS--------LPLERPLRMTDSR---L DKSIGAASPKSQAVEKTPA-------------STGLRLSSPDRL------------------------------------ ------------------------------------------------------LTTNSPKPQISDRPPE---------- ------------------------------------------------------------------------KSHASLTQ RLPPPEKVLS-------AVVQSLVAKEKALRPVDQNTQS----KHRPAVVMDLIDLTPRQKERAASPQEVTPQADEKTAM LESSSWPSSKGLG----HIPRATEK-ISVSES-LQPSGKVAAPS-EHPWQAVKSLTHARFLSPPSAK-AFLYESATQASG RTPVGAEQTPGPPSPAPGLVKQVKQ----LSRG-----LTAKSG----QSFRSLGKISASLPNEEK-----KLTTTEQSP WGLG--KASPGAGLWPIVAGQTLAQACWSAGGTQTLAQTCWSLGR-----GQD--PKPE-NAIQALNQAPSSRKCADSEK K >Callithrix_jacchus_NSD1 ------------------------------------------------------------------MDQTCELPRRNCLL PFSNPVILDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-GTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADG SESFQDPEKSHSRAQTPIVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------TLAMKQEPSCNNSPELQVKVTKTIKNGFLHFE NITCLDDADVDSEMDPEQPVTEEESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTE TQKNKQRNEVDGSNEKAALLPAPFSLGDTNVTIEEQLNSINLSFQDDPDSCTSTLGNMLELPG---TSSSSTSQELPFCQ PKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFETRK------------------ ------DERRGKIPENLGLNFLSGDVSDTQASNELSRIANSLTGSNTAPGGFLFSSCGKN-----TAKKEFETSNGDSLL GLPEGALISKCSREKNKPQ------------------------------------------------------------- ---RSLMCGSK-VKLCYIG------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPIEHSSESDNSVLEITDAFDRTENMLSM----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKIKYSRFAATNTRVKTKQKPLINNSHTDHLMNCTKSAEPG-TEMSQVNLADLKASTLVHKPQSD FTNGDLAPKFNMSSNISSENLLIKGGAANQALLHSKS-KQPKFRSIKCKHKENPVMVESSVINKECSLKCCSSDNK---G SPLASISKSGKVDGLKLLNNMHEKTRDSNVIETAVVNHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQQLMTAQNLVPYRSPGHGECSANSPVGASKVLVSGGSTHNSEKKGDCTQNSANPSPS G-GDSALSGELSASLPGLVSDRRD---LPTSGKSRSNCVTRRNCGRSKPSSKLRDAFSAKMGKNAVNRKALKTERKRKLN QLPSVTLDAALQGDREHG----GSLRGGMEDCSKEEPLQIMDHLTSEDG-DRFSDVHFDNNIKQSDPDKISEKGPSFEN- --GKGPELDSEMNSEN---DELSGVNQVVPKKRWQRLNQRRTKPRKRINRFKEKENSECAFGVLLPSDPVQEGRSEFPEH RTP-SANILEEPLTDQNHADCLDSVRPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSS--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPA-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSKKCYEAGHLGSGITESCTTSYSKDFGG--GTTKIFDK-----------------------PRKRK RQRHAAAKMQCKKVKNDDSSKEISS-SEGELMPHRTAASPKETLEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECHTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICITCHAAN------PANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKKFKKKQQGKRRSQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLPPGPSTHLAEQ-SSGTAAQAPKMSDKPPADTNQTLSLSKKALAGTCQRPLLP-ERPLERTDSRPQPLDK--- --VRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLYDKLT-PVTSRSSSPSVRS--------QSLERPLGKADPR---L DKSIGAASSRPQSLEKTPV-------------PTGLRLPPSDRL------------------------------------ ------------------------------------------------------LITSSPKTQTSDKPPD---------- ------------------------------------------------------------------------KPSATLSQ RLPPPEKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTPRQKERAASPHEVTPQADEKIPV LESSSWPASKGLG----HIPRAVEK-GSMSNP-LQTPGKA-----EDPWQAVKSLTQARLLSQPPAK-AFLYEPTTQASG RAPAGTEQTPGPLSQAPGLMKQMKQ----MVGGQQLPALAAKSG----QSFRSLGKAPASLPTEEK-----KLVTTEQSP WALG--KASTRAGLWPLVAGQTLAQSCWSAGSTQTLAQTCWSLGR-----GQD--PKPEQNTLPALNQAPSSHKCAESEQ K >Rattus_norvegicus_NSD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------MCH PKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VANRRPY-----REYYVEAFGDPSEKAWVAGKAIV MFEGRHQFEEL---PVLRKRGKQKEKGYRHKVPQKILSKWEASVGLAEQCDVPRGPKTQKCVPSSAKLDSEEDMPFEDCA ND-PDSEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSSDNIKRTSVKKGLMPFEAQK------------------ ------EERRGKSPENLGLDFLSGGVSDKQASNELSRIANSLTGSSAAPGQFLFSSCGQN-----TAKTDFETPNCDSLS GLSESALISKHSGEKKKLQ------------------------------------------------------------- ---PGQVCSSK-VQLCYVG------------------------------------------------------------- --------------AGDEEKRSDSVSVCTTSDDGSSD--LDPTEHNSEFHKSVLEVTDALDKTENALSM----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------HKN-ETKYSRYPATN-RVKEKQKSLITNSHTDHLMDSTKTVEPGTAEISQVNLSDLKISSPIPKPQPE FRNDGLTTKFNAPPGIRNENSLTKGGLANQTLLPLKC-RQPKFRSIKCKHKESPTAAETSATSEDLSLKCCSSDTN---G SPMTSISKSGKGEGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKSSKPLLFSSASSQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNVASYRTPDRGDCSSGSPVGTSKVLVLGGSTHNSEKPGDSTQDSVRLSPG G-GDSALSGELSSSLSVLPSDKRD---LPACGKIRSNCIPRRNCGRAKLSPKLRVTISTQMAKPSVNPKALKTERKRKLS RLPAVTLAANGLGNKESGGSVNGPLKGGAQDPAKEEPLQQMDLLRNE-------ETHFDSKVKQSDPDKILEKEPSFEN- --RKGPEVGSEINIEN---DEPHGVDQVVPKKRWQRLNQRRPKPGKRASRFREKENSEGAFGVLLPGDPVQKGRDDYLEQ RAP-PTSILEDSAADPNHVSHSESVGPRLNVCDKSSVSMGDLEKETGIPSLTPQTKIPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEDESLLARCRSS--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLVQSDLG------VAHAELPQLTLSVPV-APEVSPRPT-------LESEELLVKTPGNYEGKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSRKCCESGHLENGVGDSRATPHLKEFGG--GTTRIFDK-----------------------PRKRK RQRHGTARVHYKRVKKEDSARETPSSAEGELMIHRTAASPKEILEEGIEHDPGMSASKRLQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVVQNKG-FRCPLHICITCHAAN------PANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQ YPDVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIVTEEKSRKFKRKPHGKRRSQGEVTKEREDECFSCGDGGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDV--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPTATLSPSPGTQQTEQ-SSEMGTQGPKKSDQPPTDATQMLSLSKKAVTGTCQRPLLP-ERPPERTDSSSHLLDR--- --IRDLAGSGTKSQSLVSSQRPQDRPPAKEGPRPQPPDRAS-PVTRPSSSPSVSS--------LPLERPLRMTEPR---L DKSIGAASPKSQAVEKPPA-------------PTGLRLSSPDRL------------------------------------ ------------------------------------------------------LNTNSPKPQISDRPPD---------- ------------------------------------------------------------------------KSHASLTQ RLPPPEKVLS-------AVVQSLVAKEKALRPVDQNTQA----KHRAAVVMDLIDLTPRQKERAASPQEVTAQADEKTPV LESSSRPTSRGLG----HVPRAVEK-GGVSDP-LQPPGKSAAPS-EHPWQAVKSLTHARFLSPPSAK-AFLYESAIQASG RAPVGSEQTPGPPSPAPGLLKQVKQ----LSRG-----LTAKSG----QSFRSLGKISASLPNEEK-----KLTTTEQSP WGLG--KASPGAGLWPIVAGQTLAQACWSSGGTQTLAQNCWSLGR-----GQD--PKPEQNAIQALNQAPSSRKCAESEQ K >Equus_caballus_NSD1 ------------------------------------------------------------------MDQTCELPRRNCLL PFTNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTAS-GTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSTDG SESFQDPEKSDSRAQSPIVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQEPSCNNSPELQVKVTKTIKNGFLHFE NFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYEPKSENGVDVAMGNEQDSTPESRHGAVKPPFLPLAPQTE TQKNKQRNEVDGSNEKAALLPAPFSLGDTNVTVEEQLNSINLSFQDDPDSSTSTLGNMLELPG---TSSS-TSQELPF-- -------------------------------------------------------------------------------- -------------------------------VPQKILSKWEASVGLAEQYDVPKGSKNRKCVTSSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSGDEKEKPCAKSRARKSSDNPKRTSVKKGHMQFEAHK------------------ ------EERRGKIPENLGLNFVSGDVSDKQASNELSRIANSLTGSSTAPGSFLFSSCAKN-----TAKKEFETSNCDSLL GLSEGALISKRSGEKKKLQ------------------------------------------------------------- ---RGLVCSSK-VQLCYIG------------------------------------------------------------- --------------AGDEEKRSDSVSICTTSDDGSSD--LDPIDHSSESDNSVLEITDAFDRTESMLSV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKDEKIKYSRYPATNTKVKAKQKSLITNSHTDHFTDCTKTAEPG-TETSQVNLSDLKVSTLVRKTQSD FRNDSLSPKFNTPSSISTENSLMKGGATNQTLLHSKS-KPPKIRSIKCKHKENPVVLEPLITNEDCSLKCCSSDIK---G SPLTSISKSGKVDGLKLLSNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKPSKPLLFSSAPGQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGVGDCSTSSPVGASKVLVSGGPTQNLEKNEDGTQDPIRPSPS G-GDSTLSGELSASLPGLMSDRRD---LPASGKSRSNCVTRRNCGRSKPSAKLRDGFSAQMGKNTVNRKALKTERKRKLN RLPAVTLEAALQGDRESGGSEKGSSRGGAEDPGKEEPLQLMGHLTNEDG-AHFSDVRFDNKVNQSDPDKIPEKGSSFEN- --RKGPELDSEMNSEN---DEPNGINQVVPKKRWQRLNQRRTKPRKRTNRFREKENSEGAFGVLLPADPVKKR-DEFPEH RPPPSTNTLEDALTDPSHDGRLDSIGPCLNVCDKSNASIVGMEKEPGIPSLTPQPELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARCRSN--VQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPA-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGELGLSKKCYEAGRLENDITESHAASHSKEFGG--GTTKIFDK-----------------------PRKRK RQRHATAKVHCKKVKNDDSSKETTS-SEGELMTHRTAASPKEPVEDGVENEHGMTASKKLQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLNEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICITCHAAN------PASVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFTKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKRFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLPPGPSTHLADQ-SSGVAAQGPKMSDKPPADTNQMLSLSKKALAGTCQRPPLP-ERLPDRTDSRPLTIDR--- --VRDLAGSGTKPQSLVSSQKPLDRPPAVAGPRPQLSDKPS-PVTGPSSSTSVRS--------LPLERPLGTAEPR---L DKSIGAASPRPQSVEKTPV-------------PSGLRLPPPDRL------------------------------------ ------------------------------------------------------LVTSSPKPQTPDRLPD---------- ------------------------------------------------------------------------KSHGSLSQ RLPPPDTILS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTPRQKERAASPHEVTPQADEKLPV LESSSWPASKGLG----QIPRAVER-GSLSDSVLQPPGKAAAPL-EHSWQAVKSLTQARLLSQPSAK-AFLYEPATQASG RAPPGAEQTPGPPSQVPGLVKQVKQ----MVGGQQLPGLTARSG----QSFRPLGKAPSSLSTEEK-----KLATTEQSP WALA--KSSPGPGLWPMVAGQTLAQSCWSTGSTQTLAQTCWSLGR-----GQD--PKPEQNTLSALNQGPSSHKCAESQQ K >Monodelphis_domestica_NSD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------MIELPG---TSSSSTSQELQFCQ PKKKPAPLKYGVGQLVWAKFNRRPWWPSRICCDPLINTHSKMK--VSSQRPY-----RQYYVEALGDPSEKAWVAGKSIV LFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPKKILSKWEASVGLAEQRDVPKDFKVRKRIRTSAKLDSEEDMPFEDCT ND-PESEHERVLNGCLKSLAFDSETSSDEKVKPCTKSRVRKRSTSLKRTSIKKSSSAFESHK------------------ ------EERREKITETLGLNYISSDVSDKQASTELCRIASSLSAASNTTTNYLFSSCGKT-----TTKKEFETSNCDSLL GLSESVLISSSSVEIKKPL------------------------------------------------------------- ---RSMVHSAKPSRLCYIS------------------------------------------------------------- --------------AGDEEKRSDSASLWTTSDEESSDSDLDLIDQSSESDGSALEISGSFEKNESESPM----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------EKNEKVQYSRYRTKNSRVKARKRSRKTSSHLDHLLDCTKAPEPG-SEESQGADSDSKMPIIAR----- --NDNLSTKYTMPQSISHENSFVKSGLTNQPLLQSKHNKQPKARSIKCKHKESPTAEQPSVLDEDFSLKCCSSDSK---G SPLDCVVNSGKLDSLKLLSNMHEKPRDPAEIETVVVKHVLSELKELSYRSLNDDLNDSGSSKINKPLLFPSSSGPTCLPI EPNYKFSTLLMMLKDMHDSKTKEQQLMTTQNVVSYRSPGLGDCSSSSAAGGSKSLVSGGLTHKTEKNGNCIQDSVCQNPG G-SESSLTQESSGSLTGLLSKKRR---LTASSRRRANSITRRNCARSKSS-KLQDGFLAQMGKDTIESKDLKSEKKRKLN QPPNMTIETALGECKEAPTSVNKSLSSGPADSKRKQSLQLMEHLTGEDC-AHFSDVHFDPMIKKPETDKNPEKCPSFEN- --GEVLELDSEMNSESSLSDESNDVNHVAPKKRWQRFNQSRAKTSKRISRSSREKNSKSAFGGLHPCDFLLEG-NEGPED RPSSPSKVLEE-EKKQKCEGHLDIVVPQLNVCDKPNSD--GLPRESGLSNFPPQPELNT----QEKKRLRKPSKWLLEYT EKYDQIFAPKKKQKKVQEQLPKVSSLKENEVQTTQCQPSTDLQNKPVEESS-------------STKEDPPVLEREAPFL EGPIGQSELG------GGNAELPELTLSVPI-TREVSSWSS-------LDSEEPSLK-PRNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLTLLRKVWVV--------------------------FVFEK-----------------------QRKRK RQRHVAA--HCKKVRNEDSSREAQN-SEGEPITPGTTASPKDSIEESVEHDHGMPVSKKMQAERGGGAALKENVCQNCEK VGE--LLLCEAQCCGAFHLECIGLTEMPKGKFICKECRTGILCTENAHYYGE------DVKRCLLPLCGKFT???????? ??????--G-FRCSLHMCITCHAAN------PASLSASKGRLMRCVRCPVAYHANDFCLAAGSKVLASNSIICPNHFAP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREVVWVKVGRYR-WWPAEICHPRAIPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAVRFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKASDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------HPNPTEEKSKKLKRRQQVKRRSQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDV--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLTSGANTHLAEQ-PSEIPAQRPLMVDKAPGAMGQRLQLSEKTLVGTCQRPQLS-DKPLVMPDSTPQSPDK--- --SPGVSGP--RPQPLEVGQRPADTSLVVTSPRPQLSDKSSQALSGSKSPPSVRSSVAAGLRSQLLDRPLALAGPKPQSL DKSLSTISSKSQQPDRPVV-------------TTGPRLQPSDKS------------------------------------ ------------------------------------------------------PITNGPKPQTSDKP------------ --------------------------------------------------------------------------LVPLGQ RLPPSEKVLS-------AVVQNLVSNEKALRPVDQNTRP----KDRATMVLELS---PRQKERAASPHEITPQPTEKLPV LEQSPWPVNKALG----QMPRAAEK-VHPSEAVLQASGRASAPV-EHTWQAGKTLIQARLIPRPPAK-GYLFEQAPRAAG RVPVSMEQSSGSFGKA---LASGEP----MAGSPQSPGLATKATPLMVQSPRPPVKSPDLGPPAEK-----RLAMTEHPP WALG--KSPAGPG--PSGADQSLAQTCRSPGSPQTLAQTCRPLGKGLN-KGPD--PKPEQSAVPALNQTPSNHEPAESKQ K >Gallus_gallus_NSD1 ------------------------------------------------------------------MEQACEVSRRSCLV PFG--TSLPAAEPKGGPFGEPRG----------PEPPAMQLAAAKPGFGQDPSSCYIPLRRLQDLASMISAEYLGGPADG AEALPDPGSPPPRAPA---------------------------------------------------------------- ----------------------------------------------------PQEPPGGAGPE----------------- -------------------------------------------------------------------------PAALGFP LLLRDGGDDEEEEEEEEEEDDDDDEEDDDDDDDEEPEHSRGAGSPEPPRLQPAELPGSDGGPGEDAEPSGSAAAALQLIR AKKKPTPVKYEVGDLVWAKFNRRPWWPCTICHDAVLDCHSKMK--VSNRRPY-----REYYVDPLGEPSEKAWVAGKAIV LFEGRHQFEEL---PVLRRRGKQKEKGYKHKVPQRFMAKWEVSVGQAEDM-LLGGPEDQKCSQNSSELDSEKEVQSEYYS NGPGAK-KDRQLNGCFKSLAFDSKHSANEKGKSHIKPHMKKSSESRKRTRVKKSGMREEASK------------------ ------GEIQEETPESIVNNMIVGDLPEKHASHELRRIAKSITASNSTRENHLLSSFGERRFENITLKSDYGSHKSDALK NTLQGDLFSNASLEREKSS------------------------------------------------------------- ---LGILCSSK-LQIHYSAS------------------------------------------------------------ -------------EAGVEKKQTESDSSSSLSDGGNSD--VDTMDQSSERASSTLEVSDSSDKMEKEFPM----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------TSSGNIKLSMYFSQKSSRRARKKSYRDRKPLGGLVTSRLDAEFA-HRELEGGSSDAEMSLTALECSSD VRNDNLSLANKHATPQSVSKDSSWSAVANQTTLKLKNMKLPRIRSIKCKHKEKVAGLEPSLAEEESGMNHCSSDTKGFSG LQRDSLQRSGKADGQKLLNNVHEKPRDSAEIETAVVKHVLSELKELSYRSMNDDVGDSGTPKATVPLLFSSASGHGRLPI EPNYRFSTLLMMLKDIHDSKAKEQQLMTGQNIVPYRNTGTADGSGGNSASSLTSLSIVGPPFKIEKNGDCAQETVSPNSS SISNSSFSRNPPAKLPGSGTGKREPANAAVSGTNGTNCVPKRNCSKSKQSTKLGD-------KTVSNRKDLKPGGPSKF- -LSRLSRDSGEHAFRVHG-SVASPLGNEAEDTERKESVDLTEHSTDEDS-ACLSDDNLGRIGRRPEAGRNTERCASAEN- --GESPDLDSEANSESSLGDEANDVNHVAPKKRWQRFNQSSARSNKHISRSREKGNLESAF--GLNSHGFSLKGNECLGR RHSPHSKVLEADLTVQDYENHLDLVEKRLNVCGKPNNSVMDSETKLGNFAPQSEF---SAQVHSERKRLRKPSKRLLEYA EEYDHLFAPKKKSRKSQEQLRKVNSVARS-GFEGGLPAQR-SPDRETQRGPSPLVSTP-----FSTKESPPILEAECSFS -ELEPHASDP-SEQLIEGQSDFPELVLSSSD-VSEVSASP---------DAEERFLK-SGNFESKRQRKPTKKLLES-ND LDTAFMPKKEEWTPPKKG--TGPSESDSLELYSPAHFPDLG-EAS-EKLLEK-----------------------QRKRK RPRHSSAAVHSKKEKNGERLGETPR-SEGETLVHGTSTSPKGGHEDGSENDHGVPSSKKIQGERGGGAALKENVCQICEK PGE--LLLCEAQCCGAFHLQCLGLSEMPTGKFICNECSTGVHTCFVCKNCGQ------DVKRCLLPLCGKYYHEECIQKY PPTVTQNKG-FRCSLHICMTCHAAN------PTNISASKGRLMRCVRCPVAYHSNDFCLAAGSVVLASNSIICPNHFTA- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC ESCPAAFHRECLNI-EMPEG---SWYCNDCKA---------------GKKPHYKEVVWVKVGRYR-WWPAEICHPRTIPV NIQKMKHDIGEFPVLFFGSKDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGIYKKALHEAAVRFEELKAQKELRQLQED KKNDKKPPPYKHIKVNRPVGKVQIFTADLSEIPRCNCKPTDENPCGLDSECINRMLLYECHPLVCPAGERCQNQCFSKRQ YPEVQIFRTL-ARGWGLQAKTDIRK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWCVNGDTRVGLFAIVNIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKS------QPTLSEEKSKKLKRRPQMKRRSQAEVMKEREDECFSCGDGGQLVSCKKAGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDM--CGKEAASFCEMCPRSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPMGALTNGDDTQPPEQ-PPADTDPSIQPLDRLPQSVAFKLQSPEKPP-ATLALRLPPSEKPPTTLALRVQPSNKPPT TLALRLPPPDKPPAALALRLPPSNKPPTTLSLRLKPSNKPP-TTLSLRLQPSDKPPTTLSLRLQPSDRPQAALSLRLQP- EKQPVILALKPQQPDKPPTNAVLWPLDESSGDASEPHLPSKSPPGTPHSLDGSLVPAGALLQLSDEPPAIAEVLELSDKS LIDTETQEIELLDEFPAKCLHPQLSDRLLATAGTLQSQPVDEPPVAEQPQLLSKASAQSPQPQPAEKSPSSAIPHIPASE EILSPDVEVLWPLPIENVPTSPVSRILPMEKAPGLGVLRLPPPEKASFSGAVRVSAVEKAPSSGALHAFAPEKAPASGMP RILPSDKGPSLGVSWPLSLEKAHGSRSPHILPTDKALGSGALRIPLMQKVLSPGVLRPLPLEKAADAGALRPLPLEKALG SGVARPQLLERPPSLTATWPQASDKLAAAVAPRPQALDKPPAASAPRLLLSEKALRPVDQNAQPKERGAPAAELSPQQKE RTMLAGEQISWSAGKAVAHVGQVPWPTEKLQTHEQSHWPTAKALTPAEQSPRTAEKL--PEPTLQPSWEVASVP-AEQTP WTSERLRVFEQTPRPAREAPVPQEQTQWIVTNIQTIEQISWLSGKVHIPRGQD--PLPEQNTALAHNQDSVCHELADSEP K >Anolis_carolinensis_NSD1 -------------------------------------------------------------------------------- ---------------------------------MDSEASFFSAAEEHPGED-------IKFLMEKRAAAICNTKAEPQSR AERIQETQQRAPVKMR---------------------------------------------------------------- ----------------------------------------------------HNEMVSGLFPT----------------- -------------------------------------------------------------------------PVLP--- --ERIQSNSAVGSRHEKVCMYPMYLPGNTERKKEKPCNVTKVSEKEDPGQSPATL-GNLIERLEASVTSKSPATRMPAGQ NKKKPAPVKYEAGDLVWAKFNRRPWWPCKICHDPILDTHSKMK--VSNRRPH-----RQYCVETLGDPSERAWVVGKAIV VFEGRHQFEEL---PVLRRKGKQKEKDYRHKVPKRFMAKWEISVGLTSEY-LKQN-GTQKCIQTSSKMDSEKETRLMGSH EKVSLNEQNMQLNGCLKSFALDSKHFAHDKEKIVTKSRTKKSSDTRKRNRVRKSSTKLETSK------------------ ------KEYGEKVPVDNVKDMVATNVPDKQASHELCRIAKSLMGSKGTVENYLLSSFGERQFENKTKKPEHEFSHRNSQQ ERPK------VSVKKKKNL------------------------------------------------------------- ---TGLIYTSK-LQQHYSTT------------------------------------------------------------ -------------DAGVERKQVDSDSSDTFN--------FLSLDQS-IAAASTYSVLKNGDSVNKKRKE----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------RSSR-------QKNKYSARVPKSNSRRRKTLQGSLDR--------NAHMEAGRVEFHEPSFAEEVALA YRNDNLTFADKHTTLQSKGFTS------------QMDTKQLQFRNIKCKHKGATARTESFLKEDECSSDSCFSATKGSLG SHLDASTKSGNVDGPKPLNSAHENSRDSAEIETAVVKHVLSELKELSYRSLNDEAKDSGPPKTTVPLLFSSIPGQNHLPV EPDYKFSTLLMMLKDIHDSKTKEKQLMTTQNIVAYRSPNGSGSSGNNTLSDLTSLPTTGTAPKLEKK------------- -------------------------------------------------------------------------------- --------------------------QEAECQKPKE-------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------EKKRLRKPSKRLLEYA EEYDHIFPPKKKKR-SREPFRKASSLERSEGKQKDSTGKK-ARKKHLEKKPLDSVSSASSPSASSSKESPPVLEAERSLS DEPDSHSMEPRSEMPVLTLSSPNALEKEDEEGEEETSAAPPVLLPVLHPQTGGQLMK-SGRFGTKRKRKPTKKLLES-ND LDTTFIPKRE-WTSIKKCSEAGPLDTEIPEFYPTTQVLDVA-EAAPEKVPVK-----------------------QRRRK RQRRPFTAAPHKKERSKGVVGETHS-FQRDRAANGTTGSPKEITEEGSENYPGVPSSKRMQGERGGGAALKENVCQICEK PGE--LLLCEAQCCGAFHLECLGLSEMPKGKFICTECSTGVHTCFVCKNSGE------NVKRCLLPLCGKYYHEECIQKY PPTVIQNKG-FRCSLHICMTCHAAN------PTNVSASKGRLMRCVRCPVAYHSNDFCLAAGTVILASNSMICPNHFTA- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC ESCPAAFHRECLNI-DMPEG---SWYCNDCKA---------------GKKPHYKEVVWVKVGRYR-WWPAEICHPKTIPV NIQKMKHVIGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMA--KGVDGIYKKALQEAATRFEELKAQKELRQLQED KRNDKKPPPYKHIKVNRPIGKVQIFTADLSEIPRCNCKPADENPCGLDSECINRMLLYECHPAVCPAGNRCQNQCFTKRQ YPEVEIFRTL-ARGWGLQAKRDIKK------------------GEFVNEYVGELIDEEECRARIRHAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFAITNVKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPPASEDKSKKFKRR-HGKRKSQAGILKEREDECFSCGDGGQLVSCKRPGCPKVYHADCLSLTRRP AG-----------KWECPWHQCDV--CRKEAASFCEMCPRSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YAPSTESAADCQNTQPSDQ-QPAATGLKSQPSERLPLTVALRLQPSDKSPSSSLALRLKSSDKPPSSVALKLQSSDKSPS TMALKLQPSDKLPSTLALSLKPSDKLPSTLSLRLKPSDKLS-SALALRLQSSDKPLSAVALRLHPSEKSPSTVALKLQPS EKVDSTVAQKLQPSEKLSS--------------TEVHELQPSEKSTTMEASGS----------QDEP------------- --------------FAAEASGPQTTD--------------------------KHSTAENPGPERSDVSPS---------- ---------------ANRPTSPIL-----------------------------------------------EKSPATEIP KVH--------------MLEKVVAAESPRPQPLDRAIPVGPLPQSSGRPVPS-LSLRPQPVVKPVTPIALRSKPTEKSAT PEGAQPQTPNRLSAVVDSWPVLSDKDSTTTGLRSQLSDRLPAPVNSRPLLSEKALRPVDQNAQPKERPSVTLEQNTQQKE RTSVSEEQSCRPTGKFSPFVGQTTCPLENLQIHEKTPWLSTKVLPSMEQSLWTAEKLQSPEQSLCSGQEGASAPSMEQTF WSSERLCSFEQPPWPGREAPLSSGQTSWLPRNIQTFEQISWLSGKAQTPVGQDVLPLSEQNAVLVLNQDTPGHEPTESKH N >Danio_rerio_NSD1 -------------------------------------------------------------------------------- ----MNQSYKVAGRDGSECRGDPQDSRALDVRIGS-----CGQQSTKADQSSAMHFLNPGYKLSAPFAYNQRESTSNYSP LRRLQDLTTMVNHADGGLQDKDFHGRNKL--------------------------------------------------- ------------------------------------------------LMHSPIG-GNEFGIGLYNTTNSQGN------T AIQDLDKNGFSPVSSDSLEHFSPISNGFLHFDSTLFDSGDSKDNDEDVKG--EVATFKDTSKKCQKRNVAKTETQSSHRL DANKHS-------SKNTAKSDPPASPFHVPFTMMEDFDSMDDYSDSDCDLPSTENCASIFNLSKRAHSPSDSHSNPSSSP KKKQLLSVKYSIGDVVWAKFNRRPWWPCHVTTDPQIDVHTKMK--DPSRRPC-----RLYFVRMFGEIVDQAWVPAKATF PFEGGDQFEKL---PVLRRRGRQKEKDYKYTVPKRLIPSWKASVLEAEASLTKQLNSEPPLTLIQDVCVPITEDKAHKKN PA----------CPKSTTLSTPSSSLLSNGLNASVKNRLKPG--------TASKKKATKKMI------------------ ------QSQSIKLSETPSLFKSKSNPSSDKPSIATDPLDSPYSDIDSVPRILCSKRIDESLQVELEKELSTKTTKVQACK KTSKNSVDKPGKKTD----------------------------------------------------------------- --VKCLKNSKL--------------------------------------------------------------------- ------------KKSTPKDKTLKATSSRLKESSSPG-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------SSDGSFAMHSHYLPASSGLIVRALAAGEETKEKDLSHEP NSHS--PSSEHSSQTNHELSKQNWEVKNNS----------------ESSEESVDASDSPPNPTSIKRIKKRPQKNGIH-K DPPPKSHEESESKVNNESMFSDTSSSSIPSP-SISPMDAFQDIKELSFRSLVKEECSSGE-SPLRA-------------- DSNYKFSTFLMLLKDLHDSR----------------------EKEGKPLTLPPTSPSSLIKEE----------------- --------------------------PSLIPVGEEP--------PNEVLCEKEFAEQSSLPGKTS--------------- ------------------------------TPNNSKQSKAKLKSTVK--------------------------------- --KESQKPDVVIDSVSPLKKPISPVGLDVLDKSLPLLG---DLPKSSDVSAAVTDVCAKG-----TISKVAPKKRWKTFE SELGKSIKPKSDQVDSTLDEVKSVSTEPNGVFKDGLQESAHSD-----------VP-NKKDAS-ENKRLRKPSKRLIECG EEYEQIFPSKKKTKKS------------------------TESCKTGSCISNT----------TPE--QPASDQITLDAV SSSSAEKPLD----HVVAEEQKPPADVLVPPSAPKSP---SCATSLETEPC----EKKSAPLERKRPRKSVHKVLDCAIE GESVKIPKKGESRQHKTNPEES--GVRDLEKQEEAGPPPSSPCAVSAQS-----------------EGELRTSSPIQPDV PSVSQIPVEGEQSSPSKPQINNEDSLISEGFAAGLNDSAFSSRDSLS--GDLSGLSTNKRSVERGGGASLKENVCQVCEK TGE--LLLCEGQCCGAFHLQCIGLTETPKGRFICQECKMGVHTCFVCKKPDK------EVRRCMIPVCGKFYHMDCILKY SPTVAQNRG-FRCSIHVCLSCYITN------PNNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFLCPNHFTP- RKGCKNHEHINVSWCFVCSE-----------------------------------------------------GGSLLCC ESCPAAFHRECLNI-EMPQG---SWFCNDCRA---------------GKKPHYKDILWVKVGRYR-WWPAEVTQPKSVPE NISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDANNKEKMG--KGADAVYKKALNEAADRFRELLKEKEMRQLQED RKNDKKPPPYKHIKVNKQIGKVLIITADLSEIPRCNCKATDENPCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQ YTEVEIFRTL-SRGWGLRSISDIKK------------------GAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTL DKDRIIDAGPKGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKG-VELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPPSDD-KTRKLRRKVSGKRKSQSEVTKEREDECFYCGDGGQIVSCKKPGCPKVYHADCLNLSKRP AG-----------RWECPWHQCNE--CGREAASYCEMCPNSYCEQHREGMLFISKLDGKLSCSEHDPCGPDPLEPGEIRE YVPSTSIVG---------QAPNMSASGRITQPALP-----------------PAAPLFIPAQNR-----PAFQSQRD--- -------------------------------PYGDEVVDNILPSSSPKDIKEEDMSD----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------GEVVFEEG---EEEEEDLELVDDEDDEEEIDCRGMGLEDEEEEEEFEDYEDDFVNVDFV GTED--------------GDEVEGDEQETSWDELVEAEK----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Takifugu_rubripes_NSD1a -----------------------------------------------------------MRNLNGTHTQTNPFLFLLTGS SRDDMNQSYRPSVRVGSVYGSGQTERRPLNGLVSTSYGNQCGVVKRGSDPLSALQLPSPSAAQPAGFRNSQPKRADCYSQ LKRVPDLNRVVIRTDSDR--RDLDSRTDF--------------------------------------------------- ------------------------------------------------HCASPIS-DAEFDTPSVLLPPSPGSDDVEPLE PLQDVNRNEFSHRGLDGLGHCSPIPNGYLHFGSTLFDSSDIKEEQHSSRG--DLAPFYHSSRSSQGQADTDADGSRA--- EKRTYKPTLFNLMSKTISELNPTLSPSALPEITMRDGWSLGEECDSDGELNSPIDPG--------LNSPTGTKST-SNSP KKRPLPVVKYVKGDLVWAKFNRRPWWPC-HICDSDQGTHTKMK--DPSPRPC-----RVYFLETIGEILERAWVPESAIL PFKGGHEFKDL---PVLRRRGKQKEKDYKYTIPKSLLTAWKVSVAEAEYLLPERQRNTESVLLPSVNGEERVPSPVPPEK TH----------KLPSFTVDSRTT---HNGSPPNPHPVKTPAALHSNKNQPCKKKKKCLSDI------------------ ------FGHMIGGSKETSVIKVVDQFHTTTCALTEESGDSPYADLESVPMLHRPKRAAVPPVQAAHRPVRKDHGSAQVRT EFTDKANPSTGSSYS----------------------------------------------------------------- --PDCLTNSLP--------------------------------------------------------------------- ------------SNHLEQG--VSSSSDITSGSSKMH-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------SAT---------FPASSGLMTRALKAEEDTDLKEATRQS STHVRAKLSPLTPVDASTEPDVFLSSEPPS----------------GAP-------HTSPKRRARKPDKKQIRNGSLT-A PRITESNVLPDQPVEIKAEN-VPQPVSSSSPPSVSSVDGLQDVKELMFKSLVKEESSSSDLSVFRP-------------- DANYKFSTLLMLLKDMHDTR----------------------EKDGKPLTLPPSP--VLIKEE----------------- --------------------------PLVIPTAAGGGRGSCDGLTRGIKVETGQAERATVLRNSR--------------- ------------------------------VKSKKRTKPIMSSESYNFQ-----------------------DFPTKSLI ENPDKRHRKRRLPAKIKPVIPGLSSDLANLAYGREYVTGHADLAGPSSCPPGVSDTSANYLDKNCGPSTVAPKKRWQMVE DDDSKSKVKRRVSLEMNGSFIASSPDLHPEEEKQGNSDSFFSE-----------TNYSTAGNA-ESKRLRKPTKRLLESA EEYEQIFATKKKSKKS------------------------PSESSTSETSGPT----------LLHNLGAGLEAVTSTPS HVVAVDASSE----HGPSEDEVYSVVSSVSPVKTQPPPNTDAEQEPHLAP-----KTGLLLQEQKRPRKPSQKVLECTIE EVAVGPAKKKELKRPRGDSDQIRSEVKVLLDKAQAGSLRKEKPSSGAPS-----------------APVAASHCSESEDL LNLTPPHHSPSPGCSDIPKPESDLEPCSAVDQQNLHSGAVTPKPEVLSTGLIDSFTSQIDIKGKIGPTSLKENVCQVCER TGD--LLACDGHCYGAFHPQCIGLSAAPKGKFFCRECSSGVHSCFVCKTSGN------GVKRCMIPLCGKFYHNDCITAF SATQPHNKG-LRCPLHVCLSCHINY------PHSNCS-KGRLARCVRCPVAYHANDNCMAAGSLVLANNSFLCPSHFTP- RKGCKNHEHINVSWCFVCSE-----------------------------------------------------GGSLLCC ESCPAAFHRECLNI-EMPQG---SWFCNDCKA---------------GKRPRFKDILWVKWGRFR-WWPAEVCLAKDVPH NILKMKHDVGEFPVQFFGSRDFVWTYQARVFPYMEGDTHNIETMG--KGADAVYKKALSEAAERFKELQAERVMRQLQED RKNDKKPPPYRHIKVNRAIGKVQFITADLSEIPRCNCKASDENPCGVDSECINRMLMYECHPQVCAAGERCQNQAFTKRE YTPVEIYRTL-SCGWGLRAVSDIKK------------------GAFVIEYVGEVIDEEECRARIKHAQENDIFNFYMLTL DKDRIIDAGPKGNQARFMNHCCQPNCETQKWTVNGDTRVGLFALQDIPKG-KELNFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPSAEKLKLKEGKRRVSMKKKTKQEVTKEREDECFSCGDGGQIVSCKKPGCPKVYHADCLNLAKRP AG-----------RWECPWHQCDI--CGKEAASFCEMCPSSYCKEHRDGMLFISKLDGKLSCSEHDPCGPEPLEPGEIRE YVPNMTSVRPKNMPPAISMVPVSKSCSPAPTASLP-------------TEHRPPPRLYINTKTATSSFVPFKRSYLT--- -------------------------------DEGDEGDEKPVSAPSSSSSSTEERED----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------GEVEDGEVCQLEVEEDDEEEEDDDEDEEDDDDDDETGEMEIVEEEELLYSGDLLEDNSK EDTGGGNVFDDWSDYVDEEEDGEVEDDEDEWRMVVDEDK----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Takifugu_rubripes_NSD1b --------------------------------------------------MSGPYTGPNQY----SCPLTSGADLS---- LSRCHDHRTSLTMSAVTSSLKHPPVYGFTPREHCFSSSSSSSSSSSYSPLRRLQHLTTMVSQPDLVLPLREPERSWEWGS SQREMGPAADCTG---NVYSTTQNLRKEG--------------------------------------------------- ------------------------------------------------NLGKSTGGQKAAADGK------------SQDK EKKTEGGFSGPSSPAFSLESNSPFANGFLHFESSLFEDEDNSQEQDSSG------ESQDKQENVPHSHLSVSNSDSK--- --------------TSTFPTTKVVTRSQSSGQRRRYWDGSDDEWDSDTELFLLSDSY-------------SRHSM--NSP KKKSLPPLKFLEGEVIWAKFNRRPWWPCEVIVDPALGNYHRVK--EPSERPC-----RLYYVRTFGEPVEVMWVEDKSTH TFHGGFELEHL---PLLRRKGKQREQNYRCTIPKRYHNSWNSSVAEAESVLQKRPKMASSALLSIEDAFLES-SALEEAN KD----------QTTVAPSSPPAVQETTPDTNGCISSPVLSSPTMTPAKPSTLKKSGKK--------------------- --------KPNKSSKQLKSKHSKMTFYNSFDQCDRDSEECPYSDLESVPKILCPKALERQQKIPAPIQTSVAAVKEVKKQ PEVQSGLWFSKSGKDRRPKTISPVPDRTLFSKVPSKKKNSPVVNKKSLV--PGSSSGRGDLSGLPDKPKTPVPAETEPPS EQAEHLKCKNGPAASRT--------FGRDSDPAEKSPIPVETVRPPHKGGPSKGRHTIGDTTHNVTCAAPDNSDTEQALK PNTEG--ILNDESKISESVESTAHTEQSEAAKHTKPTDSNSEGPEELEADDTSGDGLDVNATEREKQARLKAKCRMPFVK LIRKDLQ---FKNSSVTVSSSDHPECTKIKKTLDANVADAPKPSDSVDNIPSSSVGQETKSEPATVSVKKMKASGGTSIL CLSAEPVKIILSSHISRLSDETGSPEEESIHLN-------VSPNTVAHPPPHPSPPPPPSPGKSINSSERSD-----ISG QTSTAN--VPSQQPVTLGFTNVLSYESSKEVIHKTKRASGKVGKHVLPEQPAHLPASSRLMTRALKAMQEQEKSGKARKA HRQQEDLVVCTSKTSTRH----PETKRDRPGKMSTHSKNNGELDEDTFSSCSTPTTLSSETADFEGNVKSEDEDLSIS-S TPPMDFIPLTSRVKSKKEDHSSEGSSSSLSSSPFSFMNAFKNLEEVSFQSLASEA--DGKPVSFKA-------------- NKNYKFSTFLMMLKDLHDTR----------------------ERDGTPLELQIGPASAHVKKE----------------- --------------------------PLVMPGEVPTAGKHELTEHIGDNNNLNPNK--LTQNEDR--------------- ------------------------------TWLVSKRPYIRKA------------------------------------- ---NSNRIKKKANRRVPSQPSRSGPGFPGLESP----PAVDSSRVGSHIQSVLDIKSNNWERLTGSHEAVTLEETAR--W SRVTENLENMMPLKQRTCSSALVLEQPNGLLADCNKTGPWLMR-----------NVGDGDKSRTAHKRVRKPSKRLIEWS EEYDQIFSTRKKSKKP----LHMIGKA-VQPVTTTPDLLAMDKDTHERPSLKF----------IPEIQTPPPEEITPTQS -ELKIPSTEN----SQ--DAPVDTVDTLTPPPETDASLPEGFIKHPG----------SAPLLGRKRKRKPTQKILEYCLE AEASAGPKKKVKTLKSISNQSLESDADCAPPSVKSKTKLLAPSSSSLTTTEVSNLGPSQANLPPICPGPSPPVPATPKPD HFELPSADINAPQAADVKAHVIRKDAAESEGEQSSLDHSFSSMKDELLLCDDTLSPSRKIIGDRGGPASMKENICQVCEK TGE--LLLCEGQCCGAFHLACISLAEAPKGKFICPECKSGIHTCFVCKKRSE------DVRRCMIPVCGKFYHGECIANF APTVAVNRG-FRCSIHVCLTCFIAN------PNSSTISKGRLVRCVRCPIAYHATDLCMAAGCVILSNNSIICPNHFTP- RRGVKNHEHVNVSWCFVCTE-----------------------------------------------------GGSLLCC ESCPAAFHRECLNI-EMPKG---SWYCNDCKA---------------GKKPRFKDILWVKVGRYR-WWPAEVSHPKTIPD NILRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVDANSKEKMG--KGVDATYKKALEEAAVRFRELQAEKELRQLQED KKNDRKPPPYKHIKVNRPIGKVQIFTADLSEIPRCNCKATDESPCGMESECINRMLLYECHPQVCPAGERCLNQAFTKRQ YSQVEIFRTL-SRGWGLRCVHDIKK------------------GQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTL DKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVSGDTRVGLFALVDIPAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------NPPSED-KGR--KRRGHGKRKKKVVVTKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRP AG-----------RWECPWHQCDI--CGKEAASFCEMCPSSYCNKHREGLLFISKLDGKLCCSEHDPCGPEPLEPGEIRE YKPE----TSGLGMAVIQSCASNSTASSVMPKTRTDREISAGAGT-CAPESLPAFSIPVPVTVPAGTSAGPRPPVGS--- -------------------------------DLPSSPHVFDLPHYSPISSYDEE-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------EEELLAEVEDDEELVEEGQQKSDEEDEEAVYLEEDEEEEDDEEEE------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Oryzias_latipes_NSD1a -------------------------------------------------------------------------------- ----MNQSYRAGLRVGSVFGSTQPELRAHN--GSTSYGNRCGVVKRGSAQATPAPLPPSSLKQTAFLGYGQPERPCCYSP QRRP---------QHPSK--SDLHPHHNI--------------------------------------------------- ------------------------------------------------HCASPIDEDDEFEAPLVQLPPSPGDDDLEPFE TLQDGSRNGFSPGSPDSFDRCSPIPNGCLHFESTLFDSSDVKEEDEGRQGGEDLTPFHHPSNSNQDRTATKCKTTWSSGV DRIPYKPTVFNLMSKTISELNPTLSPSALPEITLRDGWNLGEELDSDVELSS-FDPG--------LISPAGTNSN-SNSP KKKLLPAVRYSEGDLVWAKFNRRPWWPCRVIYDPDQGFHTKMK--VPSPRPC-----RMYFLETVGEVAERAWVPNGVIL PFEGGHQFEDL---PVLRRRGKQKEKDYKYTIPKSLLTAWKVSVAEAELLLPGRQSNSA--LSVSTGEGERIPSPVSKEK EA----------DDPSVSLDLIQSPLPTEAPNGNEHQPLKNSSVQAKKIKTVKRKKKCLSDI------------------ ------FGHIVGGSKESAAS-VGSQLNSSSRVLKEEPKDSPYADLDSVPMLHRPKRTPVSPEHDVG-AFRLKEGSPTESK NSRVKVKQILDLSHS----------------------------------------------------------------- --SDGLRNQLP--------------------------------------------------------------------- ------------CKEGKSDHKSDGCAELLLRSDEKG-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------TTP---------LPASNRLMRKALKAKEETDQKDALAPN HIPTQTPPHPRTDATWTNAPIKTEMSENWD----------------SPGNVFLPINHSSPKRRTGKLEKKLVCNGSLI-K SKRKDVSEQHFQSVKMEAESSQSEPSSASTSMSLSPEDAFPEGKELRFKSLAADN-KVTDPSVFRP-------------- NSSYKFSTFLMLLKDIHDTR----------------------EKEGNPLKIPPPP--ALIKEE----------------- --------------------------PLVIPTSADPLTGSGDGSTLRIMSENGQSGKSSVPQSTQ--------------- ------------------------------RRAKSKTQTVPAANTYQCE-----------------------DVP---LC TQSDKQRRKQRLPSKLKVRKPCPTADLANMAHGREFVSGHTDPLDPGSDPFAAPPDSSASYLDGNSEISAAPKKRWQLVE GADERMASD-------ASQLTGASPEAVPETEKHADSDSLS-----------------SAGQS-ENKRLRKPTKRLLEST EEYEQMFSSKKRLKKH------------------------GSESSKMETLGMS----------TLHDFSAAEGFDTSSSV DPAESQLEMR----PSLSQDELSPVATSASPVSPQPSFDSEAAEKTDLPLG----SDTAQIQERKRPRKLSHKVLECTIE EVSAAPARRKEQKGLADITSDVKVLVKKTQFAAAAAAAAAGKKDPVPSA-----------------SPDSA--------V ASKLPQRRSPTPQPCKSPKQEDETEPCSTEEKQTTHTGTLTPKPEVLPTGLNDSFSSQVDGKGKT--SSLKENVCQVCER PGD--LLVCEGHCYGAFHLQCVGLSVAPKGKFFCQECNTGDHMCFVCKKSGD-------VKRCIIPLCGKFYHMDCILAF SATQPHNKG-FRCPLHVCLSCHITN------PVNVFSSKGRLARCVRCPVAYHANDNCMAAGSVVLDNNTFLCPNHFTP- RKGCKNHEHINVSWCFVCSE-----------------------------------------------------GGSLLCC EACPAAFHRECLNI-EMPQG---SWFCNDCKA---------------GKKPRIKDILWVKWGRYR-WWPAEVCLARDVPN NILRMKHEVGEFPVQFFGSKDFVWTYQARVFPYMEGDTHNIEKMG--KGADAIYKKALSEAAERFKELQTEREMKQLQED RKNDKKPPPYRHIKVNRPIGKVQIITADLSEVPRCNCKASDENPCGADSECINRMLMYECHPQVCAAGERCQNQAFTKRQ YTTVEIYRTL-SCGWGLRAVSDIKK------------------GAFVSEYVGEVIDEEECRARIRHAQEHDICNFYMLTL DKDRVIDAGPKGNQARFMNHSCQPNCETQKWTVNGDTRVGLFALQDIAKG-EELTFNYNLECRGNG-KTVCKCGAPNCSG FLGVRPKN------QPPAEKVKLKEGKRRVGMKKKTKQQVMKEREDECFSCGDGGQIVSCKKPGCPKVYHADCLNLAKRP AG-----------RWECPWHQCDL--CGKEAASFCEMCPSSYCKEHREGMLFISKLDGKLSCSEHDPCGPDPLEPGEIRE YMPSMASVRPGAVAAPVLDARRASSSSSSSSSSSPYVPISYPDSQTAASKREPPPRLYINTKTATSSFIPSSSSYLA--- -------------------------------DTTEET------TTSSSASSKDERED----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------GEVEEGEVCALDMQEVEEDEEDEENDT----------EMLEEKEEEPIYGGDLVEDEEG EDEDDPWG-------SCFDDDGEVEEEDFESWGKLEDEK----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Oryzias_latipes_NSD1b --------------------------------------------------MSGPTSGPGRKSLHSTCPLTPTRDPSTHSG PSRRHSHKVDLTMSAAASSLKHTSVYGFAQMD-----SSSTLPSSSYSPLRRLQHLTTMVSQSDLVLPLKEPESAWKWGA QKSDRMEGDKNSWSDCRKFSGSQTMSREE--------------------------------------------------- ------------------------------------------------TPAQSAYGQKQAEVQKGRSESDSVRFTDSATD EKRTEGCFSGPPSPAFSLDSNSPFANGLLHFESSLFEDEENDEEQGTTSPIGGLRDKEQGTENASESSPRKLSSNSK--- --------------EAALPSAKVVTRSQSSGLRRRYWDGSEDEWYSDSELFLFDDSS-------------SKQSVQPNSL KKNSLPPLKFVEDEVVWAKFNRRPWWPCEVLVDPAQGVYHKVK--EPSDRPC-----RLYHVRTFGQPEEQVWVEDKSIH TFHGGFEFERL---LLLRRRGKQRVQNNKCTIAKRFQESWKFSVAEAEAVLPARPKMAS-ISFSMDDLCQFS-SPPETEK KS----------QPTLTPFTLPACTLS---ETSHLTNGSLSSPITPAEKPSTLGKSSSK--------------------- --------KKSKSSKDPNSKHVKKTLHNSPKDTDRNNEECPYSDLESVPKILCPKALERQTNS-VPSQPSVMVAKELKKQ PEVQSGLWFSKSGKDRRPKTTSPMPDRSLFSKLPSKKKNSSTVCKKTLITTPSYVSGSGDSAPLLDKNK---PAETSLVP RKTSSLNCTNNQAGIKTSDSVEAFVDQPDLLDREKNLLSVEVVCLKARPSASKSTDSVSEPPSSKRESKDDKRDSELSKN VDFDGQSSLFKNKKNVSETKNSVKIATKPVNDTIFDQEKKTDKTIKLCLQSKSNDSLSI----LEKQTSLVSKCRLPYVK LIRKEIKDRRYLNSSGTVFTAGTVVCKEKEKEPNGTKTCQSQQKDSR----TSASKDHSVAEPEKGSVKKVKTIDRSGKL HLSTDQSLGNRTEVSSVSAVDLGSKLVEEAVLNSKTRKETQSTSKQTHLPESKNNPGSAVPNKSSEQEKGSEEHISSISA STANALPGLCEEEPLCEDYRTPESFCSGKPKKVSKKSKRVREVNEVLKAQPAHLPASNRLMTRALRAMCDPTKQDIVGKK AEQKQILKSFRKTNHVRKNHKTKLEFYTKIKALKSHHPDKSECDQGKISSSSSPSLMFSDSSDFED-VKSEDEDLSIS-S TPPMDFIPLTSKVKTKHEGQSSDIYSPS-PPSPFSFLRAFKNVEEVSFQSLGADR--GGKPISFKP-------------- KPNCRFSTFLMMLKDLHDTR----------------------ERDGAPLELEIGPPSAHVKKE----------------- --------------------------PLVMPGEAASAGGDQETTCALTDSSAIPDKSVEALNEGG--------------- ------------------------------ASQTPKKSSNRRT------------------------------------- ---NSGWFKSKPNRRAPCSPAKSGPGFPGLESLSEMMPAEDSLEAMEWSSRVVDFQSSSWDEPGGGSDAVGAEQQEENPW SMAKQNLTAPLLLEQRERDTAE--EQPDCLVSDFIKRDSSFAN-----------ISGEDDKAVGAHKRVRKPSKRLIEWT EEYEQIFGTRKKTKKP----LQLIGKASPTPVTSAPEPLDSDNNTSDRPPSTA----------LPEIQTPPPEEIAATTP PELQIPSSQH----TKPRDTPVLSTDTLTPPPEVEPLLSEVSPKDNKEV--------SLPVLEKKRKRKPTQKILEYCLE AEASTGPKKKIKGLRNNSSSTAHSDSAPPLLKLKSKAALTPTPTSEVTP------CPPTPSIQINHRAALPPHPAPSPPE PRQLETAKADAPPAEDQNIPDDPKDVSEGEGDQCSPDHSFSSAKDDFGLCDDSVLPARKIIGDRGGPASMKETICQVCEK TGE--LLLCEGQCCGAFHLACISLADAPKGKFVCPECKSGVHTCFVCKKRGE------DVRRCMIPVCGKFYHGECITNH APTAPVNRG-FRCSIHVCLTCFIAN------PNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFTP- RRGVKNHEHVNVSWCFVCTE-----------------------------------------------------GGSLLCC ESCPAAFHRECLNI-EMPKG---SWYCNDCKA---------------GKKPHYKDILWVKVGRYR-WWPAEVSHPKTIPE NIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVDANSKEKMG--KGVDTTYKKALEEAAVRFRELQAEKELRQLQED RKNDRKPPPYKHIKVNRPIGKVQIFTADLSEVPRCNCKATDESPCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQ YSQVEIFRTL-SRGWGLRCVHDIKK------------------GQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTL DKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------NPPSDD-KGRKMKRRGHGRRKKKVVLAKEREDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRP AG-----------RWECPWHQCDV--CGKEAASFCEMCPSSYCCQHRDGLLFISKLDGKLSCSEHDPCGPEPLEPGEIRE YNPAPRALTSGLGMAVIPAAAASSSARSLRQTDRGAHEGGDGGG---AGEPFPPFSIKVPITIPVAPPAASPPHT----- -------------------------------DTPSSP--FHLPHYSPISSYEEERDV----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------FEEDEEELLEDSHDDGEAVMEEEEEEEEGLDYLELEEEQEEDEDEEE------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Petromyzon_marinus_NSD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------PPHSQPTPEKASGSPEIKLKITKTYFNGKALFE SSLCGDLVVTPE----------QPGQQQQPKESSAATAADVKQSTLLRTKGRPRKLQPVKGPPGS--------------- --------------------------------------GTSVPPVSHSVGACVLPARPVHPSTPPLPTTP---------- ---PLSADLYSIGDVVWAKISGHPWWPCMVSCDPKLGIHMRVK-VGQVKSFT-----RQYHVQFFGEAAERAWVCYRSLV MFSTREQYELLVSELAKRTSSASERTKILKPMASRVRSQWFVGVAEAEAAAALCREERN--------------------- ---------------------EKFTFIYFDVKP-KDMGHHKGQTPSSSQKKKTPSQNNIIET------------------ ------------KLTLNIPPRFYISFNNVEQRCHGCVDCAASHSSG---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------------SVNLDV IFSSSHRRKLDDGSS---LTAASVSGQERDDVGNDEVRRAREHTN------------------------------GAGGG GGLTPKKKRGISLENNVAVRSWHRSI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------IMFARNAHSS DGIYPATFITATSNLCLTV------------------------------------------------------------- --------------------------------------------------------------EAESQSSLLRRPQAGESG VEESVPRKRVRKEPKNTAAQCHTKPALCS------------------------------------GVWMVAKLSDSCKPL KKRSRASTTDSTSPSECDEEGALPPDAEVMVTRSLIYHACSAASPAGQGEAVYQEGSEDSQSEGKRGSSKRDALCLACEK TGGGSLVSCEGQCCGTFHVECLGVQTAPGDKVMCNECSTGLHVCFACKCAGA------EVRRCAVSSCGRFYHEECVQRS SAAVFEGRR-FRCPLHVCLSCHLAYP------ASSRASRGRMQRCVRCPVAYHTSDSCLAAGSKVLSPYSIVCSGHFTP- -NKRDSTWHVNVNWCFLCSRGVIGAPLPDAGLALFEQSSHYLLSEYKRSSELGKLPMIPVVPAAAAKACGK--GGCLLCC ESCPAAFHPECLGM-EPPEG---TWCCAECRA---------------GKKPQYHDIVWVKLGNYR-WWPAEICQPRNIPQ NIQNLKHTVGQFPVQFFGSHDYYWTTQGRVFPYMEGDK-GSTDYKT-NCLNKTFKRALLEAAARYQALKAQRETREAQET ERSERKPPTYKHIKSNKPVGRVQVYTADVSEIPRCNCKPTDESPCGLDSECLNRMLQYECHPSICPAGDRCQNQAFTKRA YPPSQIVKTA-GRGWGLLTLVSIRK------------------GEFVNEYVGELIDEEECRKRIKYAHEKNLSNFYMLTI EKDRIIDAGPKGNFSRFMNHSCQPNCETQKWTVNGDTRVGLFATSDIATG-TELTFNYNLDCLGNE-KTICKCGAPNCSG FLGVRPKTA-----AAAATEEKAKKAKRKARGRRPRTETARAEHEDECYRCGDGGELVMCDKKACPKAYHLSCLNLTKPP FG-----------KWECPWHHCDV--CGRPSVRSCELCPNSFCKEHQAGLLTRLTRDGRICCEEHD-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Latimeria_chalumnae_NSD1 -----------------------------------------------------------MDQAHELCRINCLLPFSNPVE LEAPDNKQFNGRDPGNPFEPGNGCTMELPAAFQNTASKSAQDHSACYSPLRRLQDLASMIN--MDYLDINGSKDGAKPVQ APGKIHLRPEVPQAYTTLKTDYRSSPTES--------------------------------------------------- ------------------------------------------------ESIHNSSPELKLKITKVQSRCFEPVFGEGAQG DIQITSLDQASEREKEGKQRTKRKKKVAKNDISCHLDSKEENVTEKRRRRRKTTSKLERSGGSKTEFAPLTPMLHAEIKQ NCRELQEN----TVGKIETIELCRVPLKLENSSCKIEELYHEAKFSYTAETKDNTEKTENKIKPRGADTIHSSVNLDFCS IKKKPVPVKYKVGDLVWAKLNRRPWWPCRVCSDPLLDTHSKMK--VPSRRPC-----RQYYVQNVGDLSDQAWVAGKATV LFEGRHQFEEL---PVCRR-GKQKEKPYTYKISQKLLPVWEMSVKIAEDAFSKSAKDQGYSSESKDSSKAKDDISTEMES HA----------KCLINGCVKSSDSFCGKSGSEKIKIPSETTAKKNSSGNKRRARVRKITNT------------------ ------CEKFVTESADRIKENHIKHPTSGEREDSVGGLEDDHTSNFGSKHNAAEDKVSIVLSNTGNKTTEKKVSMSTGAI NDLVCSPCLHYKQTPS---------------------------------------------------------------- --TTLLDVSCEI-------------------------------------------------------------------- ------------NKTKVEKKKDSGAFCNTEEHQKSGRKLKGLSTLSNNVKKTPRSLKKN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------VKKERKKCTKSNETVEGYNSGPEEEETLSLKSDIAVLEDKCSETGPTGLETLTTALSRKNSEV STKLPEKFLIASPVHHNSNEDSKLSTLSHMIASPFNPFSKNTSRPPRNRSVKFRSEDVGFPLPPKTESATKCPSVEVK-E LAGPSLVSAAKAKGVHDQKPSSSPHGNSTEIENAVVKHVLSELKELSFRSLNKEDGNSVTSKTMAPKDPTGVCVANNLHA NQNYKFSTLLMLLKDFHDKSKEVKKTAHQNMVGFNVPHTVNCSETNSSEELKPSVSNGSVDGSDEAEGVIQEVSPNRNPE K------LPVVRITATKLSEIKNESIPSNVRNATKNVTSTLAKSKRVVKKDNLSKEIDSSTNEDSKFEFHVDSSVNHVHN GVDDSALEKCRHFNGSVKKLVDFRSTETDQVINKDHTPREEESLQKTDK-----------------------KPKMDKGI LEKAITDEEDGAQQEAKFNNKHSPSCTSTDLNSVAPKKRWKQFSQNTVKTNKRLIKSRERHRSLVPSEEIKDCSRNLKCK PELETVSQQAEDKLCENLKQNKSLSTATLEILDCVKSSKFAQFSLQR-SIPQLTLAKDLKFLQSEKKRLRKPSKRLLEYT EEYDQIFAPKKKQKKSVDHSLKVRCMEQASLLRALLPEQQTSSPGAPAPVERA----------SSPGAPAPAERASSPGA SAPAERASSP----GAPAPAEQASLPGALPLAEQASSPRASPLLEQASLPG-----ALPPVYERKRLRKPTKKLLES-TD LDPGFVPNKFSCALSLSFFSNNSLENGSFQYCAFSKHSGHEKGSKVLFW---------------------------LLRK RLRQKASSSVTPNKKVKSEPREEIPDAEGQTSSSDHGDHLKEQAEDMCDPDRAVSSLKKPQTERGGGAAMKENVCQVCEK PGE--LLLCEAQCCGAFHLQCIGLTRMPEGKFICSECSTGIHTCFICKINGA------DVKRCLVPICGKFYHEECVKKF PPTAMQNRG-FRCSLHTCLSCHAVN------PSNSSASKGRLLRCVRCPVAYHATDFCMAAGSMILASNSIICPNHFTP- RKGCKNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC ESCPAAFHRECLNI-DMPEG---NWYCNDCKA---------------GKKPHYKEVVWVKVGGYR-WWPAEVCHPKNIPP NIQKMKHDIGEFPVHFFGSKDYLWTHQARVFPYMEGDVSSKDKMG--KATDGTYKKALQEAAVRFEELKAVKEMRQLQED KKNDKKPPPYKPIKVNRPVGKVQIFTADLSEIPRCNCKASDENPCGLDSECINRMLMYECHPNVCPAGEGCQNQCFTKRN YPHVEIFRTM-GRGWGLCSKVDLKK------------------GEFVNEYVGELIDEEECRARIKHAQENDISNFYMLTL DKDRIIDAGPKGNHARFMNHSCQPNCETQKWTVNGDTRVGLFALCDIPAG-SELTFNYNLECLGNG-KTVCKCGSPNCSG FLGVRPKN------QPSSTDDKSKKLKKKPQLKRKSQAEVTKEREDECFSCGDPGQLVSCKKPGCPKVYHADCLNLKKRP AG-----------RWECPWHQCDM--CGQEAASFCEMCPSSFCEKHRDEKLFISKLDGRLCCTEHDPCGPNPLEPGEIRE YTLPPK---------------------------------------------NQPDNQNPPTNESTIKPIKLQS------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Ciona_intestinalis_NSDa -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------RCIRCPTAFHIGDDCIAAGSILLPGLNIICPDHFEP- LKTTPHHQPVHVSWCFVCSK-----------------------------------------------------GGQLMCC ETCPAAFHPLCVGFPQTPEG---EWFCRDCRY---------------KKRPLYGEIVWVKLGSYR-WWPGEITHPNEIPD NIQRLHHGIGEFVVRFFGSNDYFWLNKRRVFAYQEGDTGATSTNCS-RGISSVFNKALQEAQESFEELMSYRQKLQDVKT QK---KRPMYKHIKTNKPVGGVQIYTAELSEIARCICKKTDPNPCGPESECLNRMLMYECHSDLCPAGEKCQNQRFQKRE YPSSEVFKTS-WGGWALRAKDLIKK------------------GEFVSEYVGELVDSEECMRRIEDAHKNNVTNFYMLTI DKDRIIDAGPKGNYSRFMNHSCDPNCETQKWMVNGDTRVGLFALREIQDG-EELMFNYNLDCLGND-KTPCMCGSANCSG FIGVRPKP------QMGENGNNG-KSVKRKRRRQESKNVP--KHDDFCFRCRQVGTLVCCDVRACQRAFCLRCLRLTKSP FG-----------KWQCPWHHCDF--CGRRAQNFCHFCPNSFCSSHVANQLLPSVPNKYDCCTDHD-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Ciona_savignyi_NSDb -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----ELIHCIGGCCQSFHPGCLEDKVSSVADFTCKHCKDDNHACFICKKNSSVETQLGEVKRCTVLKCGRSYHSECLIAQ AMINSS-----KCTLHQCGTCTTK-------EKEDTNNVANPSRCIKCPTAFHIGDECIAAGSIMLPGLNIICPDHFEP- LKTTPHHQPVHVSWCFVCSK-----------------------------------------------------GGELMCC ETCPASFHPICVGLDKTPDD---EWFCRDCRN---------------KKRPLYGEIVWVKLGSYR-WWPGEITHPNEIPD NIQRLQHGIGEFVVRFFGSNDYFWLNKRRVFAYQEGDTGATSSNCS-RGISSVFNKALQEAQESFEELVSRQQKIQDVKQ QK---KRPVYKHIKVNRPIGSVQIYTAELSEIPRCICKKTDPNPCGPESECLNRMLMYECHADLCPAGDKCQNQHFQKRD YPQSEVFKTT-WGGWALKTKTLIKKVTLPGHAPIFMIINSNPQGEFVSEYVGELVDGEECMRRIEHAHKNNVTNFYMLTI DKDRIIDAGPKGNYSRFMNHCCDPNCETQKWTVNGDTRVGLFALGEIAAG-EELTFNYNLDCLGND-KTPCMCGSSNCSG FIGVRPK---------NGNGNN--KSVKRKRRRNESKNLP--KHDDFCFRCRQVGTLVCCDVRACQRAFCLACLRLTKPP FGECLLFVLSGACKWQCPWHHCDF--CGRRAQHFCHFCPNSFCASH---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Drosophila_melanogaster_NSD -----------------------------------------------------MKLSTDAHSEIEGDAAHGNVLCNSASD SLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVRLLDKPGQNPVQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNR KRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAAALNNSSAG--------------------------- -----------------ETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGI RPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVHI KQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLS IVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLL TFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTK-VVIWRQAIEEAQAMTQIPYSDRL--------------------- ---------------------EKFYQTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDN------------------ --------------LHNKQGTQLLAVKRERSESPFSPAFSPVKSKN---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------EKRAKRRKLSNG TEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNR-----------------------------SDEKV EKVLLSVVSNIWSLKQIQLRELER-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------DLASGEIEEPLG SSVVGRGSGVGTIKRLSNR------------------------------------------------------------- -------------------------------------------------------------LMTMMVRRSMTPVVTPSTT PAPSEPDRRLSEPPKTKKPVNRPIEEVIED---------------------------------------------ILQLD SKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKE VVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLL---------TCSQPMCGKRFHTSCCKYW PQASSSKHS-ARCPRHVCHTCVSDDP----SGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIA- ----KADAHVNVLWCYICVK-----------------------------------------------------GGELVCC ETCPIAVHAHCRNIPIKTNES---YICEECES---------------GRLPLYGEIVWAKFNNFR-WWPAIILPPTEVPS NILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKS--QLFRNYTTGVEEASRFLPIIKARRQEQDMERQ SGNKLHPPPYVKIKTNKAVPPLRFSQ-NLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRK SPRLEVVYMN-ERGFGLVNREPIAV------------------GDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGV EKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVN-SELTFNYLWDDLMNNSKKACFCGAKRCSG EIGGKLKDD-------AVKAHAKLKQMRRAKASAVRIHVKPKKTPKVKHISADDEPMDAKDE------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Capitella_teleta_NSD -------------------------------------------------------------------------------- ----------------------------MEDLSQEFSPERVSAEAAASPPSVPSPASHAPVINASPTPIKLRIRRSVCDG KTEVSSEEIIEGPP------------------------------------------------------------------ -------------------------------------------------APSPQIPVAAAAPPPKRARTKG--------- -----------------------ELKKQLQEKRGKRGGLLPVLPPPPEPLPPPLQPPLPPITQKP--------------- ----------------------------------------KLELKQPD-------------------------------- --PDAKDAKFLIGDMLWGRVAGHPWWPCMVGYDPFQGIFTRIQ-----RAKA-----RMTHVHFFGSEGERGWVPDKSLI PFEGKEAFEKYCS----MMQDKDKKNKKNYIIAGRRRKAWEFAVKDAESAQPLSKAERQ--------------------- --------------------------ALFAVAPPVEDSLKRPSDTTPPVAKRQKRSQSITSP------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MENQSVAQFTVFCMRRRDALKRDHPDFSPEQVDELLKT---------------------------------- ----QWDSLDADQKSLFIPMG----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------QDFAHLS KHMPQTTAPTGKSDGPPS-------------------------------------------------------------- ----------------------------------------------------------------VEELKPRNLDSLLDKV VEQHVSEEVCFSGDAFHLQHFNLQGD------------------------------------------------STKDEI APKKKSRTCKVKEESSDSTDAQDSDVAGEKAR-------RLAMPSIEWTDGCPPYDLELLKLTTTSASVRKESLCGVCEK PNE--LLHCVGPCLGHFHAACLGLSVVPTSTFKCDECSTGIHSCFTCKKADK------ETKKCSSHGCGKFYHMKCVSGI RSAKVDNGH-FTCPLHACATCAVDD------VYKPKPKQNRLLRCVRCPTAYHAGDFCVSAGSQQLNGQSIICGDHFQP- VKGNSHHTMYHMSWCFACSV-----------------------------------------------------GGTLLCC DTCPCAYHAECLNI-QPPEG---AWHCELCTN---------------GKRPVFGDIIWVKLGMYRRWWPSEICHPKNVPT NIQNMRHQLGEFPVKFLGTHDYFWLHRGRVFEYEEDDKATTLKASESNSLGKSFNQAVKEAALVNKMWNTIKEQLKGDID QK---KPSAYKHIKSNFPIGSVQIYKSPSN---VCECTAQMENPCGEQGNCLNRLTLVECHPQMCKAGEKCQNQRFMKRE YPDQSAYRTG-ARGWGLKTNVDIKK------------------GQFVNEYVGDLIDSEECQRRIKAAHDNNIVNFYMLTL DNRRIIDAGPKGNLSRFMNHSCDPNLVTQKWTVNGDVRVGLFAVCDIPAG-TELTFNYNLAAVGST-KTVCQCKSANCSG FLGIPPKQ------NSSSDSEKPKKKKKKKEKKKK-------IYDNDCYRCGDGGELLLCDQTTCPRAYHLKCLNLEKPP TG-----------QWCCPWHHCDD--CGRRALKLCSECPNSFCPQHLEGNIF---------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Helobdella_robusta_NSD 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------MTT------TALKCNVNNCSFYYHVNCLKTL KYGKCEKRS-LTCSHHTCASCAADAE------KMGMAERGKMLKCIVCPNAYHTGDLCIAAGSRILSNGWIICGDHHQMS DNKRKHQEHVNVAWCFSCGE-----------------------------------------------------GGSLVCC ENCPASFHPACCET-PPSEEE--KWICELCLD---------------GKRPLYGEIVWCKAGIYR-WWPGEICHPRNVPT NIQNIAHGIGDFPVRFFGSYDYLWTHKGRVFSFQEGDKKGAKRGSS-KSFVEVFSKALDEADVAARIYYDERNKK---DL KVYDKKPGPYKHVKSNVPIGKVEIFKVPLTEIPRCQCSPEMPSPCGPDSDCINRLMMYECDVAVCPAGEMCLNRAIQSRW DVDTEYFRTADNRGWGLRTKIDIKK------------------GQFIHEYVGDLIDEEECKERLRRAKESNVTNFYMLTL DKNRIIDAGPKGNNSRFMNHSCQPNCETQKWNVNGDVRVGLFAMRFIEAG-EELTFNYNFDCLGDK-KTICHCGMPVCSG FLGERPKS-------TSTEAERTLITKKKKRRARNVTK-DLIVHEDLCFRCGLGGELVLCDKTGCTKSYHLDCLNLNHLP RG-----------KWICPWHLCNEENCGKWSSQLCSMCPNSFCSRHTEGNIIVLAT-GRIVCDDHPPSCPQL-------- -QYLLSKDWEELKSRD---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Trichoplax_adhaerens_NSD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MISPK KVKGRGNKATSNKVEKRKLSKPRSRARESPGS---------------------------------------KGVCMLCEG IGE-KLVTCQGGCFSKFHLECLGITEWPVKGFKCQECTSGTRKCFVCGSSEP------PVLPCKVAGCGKCYHDTCISQF TCGQVSEEGCIRCPRHVCTTCTAFAISKN-DENFDVVIQKKLARCIYCPVSYHASEACLPAGCKVLNSSAIICNKHLDA- -----KVKHVNVGWCFACSQ-----------------------------------------------------GGNLICC ELCPASYHENCLDEKCRPKPNEDKWFCRGCID---------------GKFPVIGDIVWVKIGAYR-WWPAEVCNRKYVPD NILALKHGPGEFSVQFLGSHDYSWTSISRIFGYEEEDIDGRASKLGRKGIVKSFGKALKEAEEKFTQRKISREKKEAKSQ ERRSQKPPSYKHIKMNKLVD--ALIRPNLTEYTPCSCKPTDEAPCGSSSNCINRMLMCECNSSMCPAGDKCQNQRFQKLE YAKSEIFKSN-QCGWGLKSAEDIYA------------------GTLVVEYVGELLNEKTCYQRIKMAQSKGEKNFYMLNI DKDVIIDAGQKGNLARFMNHSCQPNCETHKWTVNGLTCIGLFAIDDIKQG-EELTFDYRLHAVGND-QAECHCGSKLCRK YLGAKIKSTTTTKGKDGGNNKSNKNNNGQGKRKKRKKRKRAIKHEDECYVCGDGGQLIMCSRKSCYKCYHLECLTIDGIP RG-----------KWDCPWHHCDI--CGKAANQLCSRCPNSFCKTHANGRIQSKNSCGEMVLLCHQCIDDDQDINKSN-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Pan_troglodytes_NSD1 ------------------------------------------------------------------MDQTCELPRRNCLL PFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-GTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADG SESFQDPEKSDSRAQTPIVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQEPSCNNSPELQVKVTKTIKNGFLHFE NFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTE TQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPG---TSSSSTSQELPFCQ PKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHK------------------ ------DERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKN-----TAKKEFETSNGDSLL GLPEGALISKCSREKNKPQ------------------------------------------------------------- ---RSLVCGSK-VKLCYIG------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPIEHSSESDNSVLEIPDAFDRTENMLSM----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPG-TETSQVNLSDLKASTLVHKPQSD FTNDALSPKFNMSSSISSENSLIKGGAANQALLHSKS-KQPKFRSIKCKHKENPVMVEPPVINEECSLKCCSSDTK---G SPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPS G-GDSALSGELSASLPGLVSDKRD---LPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLN QLPSVTLDAVLQGDREHG----GSLRGGAEDPSKEDPLQIMGHLTSEDG-DHFSDVHFDSKVKQSDPGKISEKGLSFEN- --GKGPELDSVMNSEN---DELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEH RTPPSASILEEPLTEQNHADCLDSVGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSS--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPA-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGG--GTTKIFDK-----------------------PRKRK RQRHAAAKMQCKKVKNDDSSKEIPG-SEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICITCHAAN------PANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLPPGPSTHLAEQ-STGMAAQAPKMSDKPPADTNQTLSLSKKALAGTCQRPLLP-ERPLERTDSRPQPLDK--- --VRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPS-PVTSPSSSPSVRS--------QPLERPLGTADPR---L DKSIGAASPRPQSLEKTPV-------------PTGLRLPPPDRL------------------------------------ ------------------------------------------------------LITSSPKPQTSDRPTD---------- ------------------------------------------------------------------------KPHASLSQ RLPPPEKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTPRQKERAASPHEVTPQADEKMPV LESSSWPASKGLG----HMPRAVEK-GCVSDP-LQTSGKAAAPS-EDPWQAVKSLTQARLLSQPPAK-AFLYEPTTQASG RASAGAEQTPGPLSQSLGLVKQAKQ----MVGGQQLPALAAKSG----QSFRSLGKAPASLPTEEK-----KLVTTEQSP WALG--KASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGR-----GQD--PKPEQNTLPALNQAPSSHKCAESEQ K >Gorilla_gorilla_NSD1 ------------------------------------------------------------------MDQTCELPRRNCLL PFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-GTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADG SESFQDPEKSDSRAQTPIVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQEPSCNNSPELQVKVTKTIKNGFLHFE NFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTE TQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPG---TSSSSTSQELPFCQ PKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHK------------------ ------DERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKN-----TAKKEFETSNGDSLL GLPEGALISKCSREKNKPQ------------------------------------------------------------- ---RSLVCGSK-VKLCYIG------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPIEHSSESDNSVLEIPDAFDRTENMLSM----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPG-TETSQVNLSDLKASTLVHKPQSD FTNDALSPKFNMSSSISSENSLIKGGAANQALLHSKS-KQPKFRSIKCKHKENPVMVEPPVINEECSLKCCSSDTK---G SPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPS G-GDSALSGELSASLPGLVSDKRD---LPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLN QLASVTLDAVLQGDREHG----GSLRGGAEVPSKEDPLQIMGHLTSEDG-DHFSDVHFDNKVKQSDPGKISEKGLSFEN- --RKGPELDSVMNSEN---DELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEH RTPPSASILEEPLTEQNHADCLDSVGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSS--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPA-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGG--GTTKIFDK-----------------------PRKRK RQRHAAAKMQCKKVKNDDSSKEIPG-SEGELMPHRTATSPKETVEEGVEHDPGMPASKKIQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICITCHAAN------PANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKAKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLPPGPSTHLAEQ-STGMAAQAPKMSDKPPADTNQTLSLSKKALAGTCQRPLLP-ERPLERTDSRPQPLDK--- --VRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPS-PVTSPSSSPSVRS--------QPLERPLGTADPR---L DKSIGAASPRPQSLEKTPV-------------PTGLRLPPPDRL------------------------------------ ------------------------------------------------------LITSSPKPQTSDRPTD---------- ------------------------------------------------------------------------KPHASLSQ RLPPPEKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTPRQKERAASPHEVTPQADEKMPV LESSSWPASKGLG----HMPRAVEK-GCVSDP-LQTSGKAAAPS-EDPWQAVKSLTQARLLSQPPAK-AFLYEPTTQASG RASAGAEQTPGPLSQSSGLVKQAKQ----MVGGQQLPALAAKSG----QSFRSLGKAPASLPTEEK-----KLVTTEQSP WALG--KASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGR-----GQD--PKPEQNTLPALNQAPSSHKCAESEQ K >Macaca_mulatta_NSD1 ------------------------------------------------------------------MDQTCELPRRNCLL PFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVS-GTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADG SESFQDPEKSDSRAQTPIVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQELSCNNSPELQVKVTKTIKNGFLHFE NFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTE TQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPG---TSSSSTSQELPFCQ AKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHK------------------ ------DERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKN-----TAKKEFETSNGDALL GLPEGALISKCSREKNKPQ------------------------------------------------------------- ---RSLVCGSK-VKLCYIG------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPIEHSSESDNSVLEITDAFDRTENMLSM----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPG-TETSQVNLSDLKASTLVHKPQSD FTSDDLSPKFNMSSSISSENSLIKGGAVNQALLHSKS-KQPKFRSIKCKHKENPVMVEPPVTNDEYSLKCCSSDTK---G SPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSPS-QNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANLSPS G-GDSALSGELSASLPGLVSDKRD---LPVSGKSRSNCVTRRNCGRSKPSSKLRDAFSAQVVKNTVNRKALKTERKRKLN QLSSVTLDAVLQGDREHG----GSLRGGAEDPSKEEPLQIMGHLTSEDG-DHFSDVHFDNKVKQSDPGKISEKGPSFEN- --GKGPELDSVMNSEN---DELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFGALLPSDPVQEGRDEFPEH RTS-SASILEEPLTDQKHADCLDSVGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSS--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPA-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGG--GTSKIFDR-----------------------PRKRK RQRHAAAKMQCKKVKNDDSSKEIPS-LEGELMPHRTAASPKETVEEGVEHDSGMPASKKMQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICITCHAAN------PANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLPPGPSTHLAEQ-STGMAAQAPKMSDKPPADTNQTLSLSKKALAGTCQRPLLP-ERPLERTDSRSQPLDK--- --VRDLAGSGTKSQSLVSSQRPLDRQPAVAGPRPQLSDKPS-PVTSPSSSPSVRS--------QPLERPLGTADPR---L DKSIGAASPRPQSLEKTPV-------------PTGLRLPPPDRL------------------------------------ ------------------------------------------------------LITSSPKPQTSDRPPD---------- ------------------------------------------------------------------------KPHASLSQ RLPPPEKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTPRQKERAASPHEVTPQADEKMPV LESSSWPASKGLG----HMPRAVEK-GSVSDP-LQTSGKVAAHS-EDPWQAVKSFTQARLLSQPPAK-AFLYEPTTQASG RAPAGTEQTPGPLSQVPGLVKQAKQ----MIGGQQLPALAARSG----QSFRSLGKAPASLPTEEK-----KLVTTEQSP WALG--KASSRAGLWPIVAGQTLAQSCWSPGSTQTLTQTCWSLGR-----GQD--PKPEQNTLPALNQAPSSHKCAESEQ K >Nematostella_vectensis_NSD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MFCGDCNSAYHPDCIGLSTAPKGKFKCDECTSGVHSCFVCRQTG-------DVKACSQPLCSKFYHKECLQSY KCSKIDGDR-IYCPLHFCSTCISN---------KTPVNRGRLTKCIRCPTAYHAG--CLVAGCMPITSHLMVCAKHFLP- NKSKAHHTHVNVNWCFVCSI-----------------------------------------------------GGTLICC ESCPAAFHPECISYEGIPEG---RFYCKDCVE---------------GKSLLYGDIVWVKLGMYR-WWPAMICNPRDVPT NIQSMRHQPGEFPVMFLGSHDFYWIHKGRVFSYQDGDKGT-ESGNN-KYLAKVFKKALVEAKEKYDEWKKAREDKAEQDL QRFCKKPPQYKHIKTN-KCTTAQRIILDPSEMPVCECTP--DQACGQDANCLNLMLQFECVASRCPAGDKCQNQRFQKRQ YVDCEPFRAH-SRGWGLRSKQAIKK------------------GTFVIEYVGELIDDATCRERVKKGDDD--TNYYMLTI DKDCIIDAGPMGNLSRFMNHSCYPNCETQKWTVNGEVRVGLFTSRDVESQ-EELTFDYCLDCHGNE-KKKCHCGSQNCSG FLGVRPKTQ-----NAQMNEDKAKNAALKRRKRKPKKPAVKQVHEDDCFICGDGGQLIMCDRSGCLKCYHVDCLNLDKKP QG-----------RWQCPWHFCDN--CGKRATVLCSECPNSFCRSHAQGQINSTDKNTFLCTDHVDEVLPGMTDKFLATD QVLNALDLINGDLTGIRPTELDHLQQKPEYLELGS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Otolemur_garnettii_NSD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPRGSKSRKCVTSSIKLDSEEDVLFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGFMQFEAHK------------------ ------EDRRGKISENLGLNFISGDVSEKQASNELSRIANSLTGSSAVPGNFLFSSCGKN-----TAKKEFETANCDSLL GLPEGALISKRSGEKKKPQ------------------------------------------------------------- ---RGLLCSSK-VQLCYIG------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPVEHSSESDNSVLEITDAFDRTENILSM----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKIKYSRYPGTNSRVKAKQKPLITNSHTDNLTDCTKTAEPR-TETSRVNLSDLTVSTPVHKPQSD FRNDGLSPKFSMASSISSENSLIKGGATNRPLLHSKS-KQPKFRNIKYKHKETSVIVEPPVTNEDCSLKCCSSDMK---G SHLASISKSGKVDGLKLLNNMHEKTRDSNDIETAVVKHVLSELKELSYRSLGEEVNESGTSKPPKPLLFSSASSQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTASNLVSYRSSGRGDCSTSGPAGASKVLVSGGSTHNSEKNRDGIQDSTNPIPS G-GDSAVSGELSASLPGFVSNRRD---IPASGKSRPNCVTRRTCGRSKPSSKLRDAFSAQMGKNTVNRKALKTERKRKLN RLPAMTLEAALQGDRESG----GSLTGGTEDLGKDESLQLTGHLTGKDGTEHLSDGHLDNKVKKPEPDKIPEKGPGFENK KGQKGQELDSEMNSEN---DEPNGVNQAVPKKRWQRLNQRRTKPRKRTNRFREKENSEGAFGVLLPSDPVQEKRDEFLEH RTPPSTNIPEDALTDTNRAGHLDSVGSQLNIRDKSSTSLGDVEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLVARCRSS--AQNKQVDENNL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPA-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSKKCYEAGRLENGIAD---ASRSKEFGG--GTTKVFDK-----------------------PRKRK RQRHATTKVQCKKVKSDDSSKETPS-SEGELMTHRTTGSPKETVEEGIEHDSGMPASKKMQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVIQNKG-FRCSLHICITCHAAN------PASVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAIPS NIDKMKHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKKFKKKQQGKRRSQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPP-VQLPTGPSTHPAEQ-SSGATAQEPKMSDKPPADTNQMLSLSKKALTGTCQRPLLP-ERLLERPDSRTQPLDR--- --VRDLAGSGTKPQSLIPSQRSLDRPP--AGPRPQLSDKPS-PVTGPSSSPSVRS--------QPLERPLGMADPR---L DKSIGAASPRPQALEKTPV-------------PTGLRLAPPDRL------------------------------------ ------------------------------------------------------LISSSPKPQTSDRPSD---------- ------------------------------------------------------------------------KSHASLSQ RLPPPEKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTPRQKERAASPHEAIAQADEKMPV LESSSWSASRGLG----PMPRAVEK-TSMSDSRLQPPGKASAPS-EHSWQAVKSLTQARLLSQPPAK-AFLYEPASQASG RVSSGAEQSLGPPVQPLGLGKQAKQ----MVGGQQLSGLAAKSG----QTYRSLGKTSASLPTEEK-----KLATTEQSP WVLG--KTSPGAGLWPMVAGQTLAQSCWSTGSTQTLAQTCWSLGR-----GQD--PKPEQNTLPALNQAPSSYKCAESEQ K >Bos_taurus_NSD1 ------------------------------------------------------------------MDQTCELPRRNCLL PFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTAS-GTSQNAYGQDSPSCYIPLRKLQDLASMINVEYLNGSADG SESFQDPEKSDSRAQSPVVCTSLNPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQEPSCNNSPELQVKVTKTVKNGFLHFE NFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYEPKSENGVDVAMGDEQDSTPDSRHGAGKPPFLPLAPQTE TQRNKQRSDVDGSHEKAALLPAPLSLGDTNVTIEEQLNSINLSFQDDPDSSTSTLGNMLELPG---TSSSSTSQELPFCQ PKKKATPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDIPKGSKNRKCVTSSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHMQFETHK------------------ ------EERRGKIPENLGLNFISGDVSDKQASNELSRIANSLTGPSTAPGSFLFSSCAKN-----TAKKEFETSNCDSLL GLSEGALISKRSGEKKKFQ------------------------------------------------------------- ---RGLMCSSK-VQLCYIG------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPVDHSSESDNSVLEITDAFDRSENLLPV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKVKYSRYPATNTKVKAKQKSLITNSHTDHLINCTKTTEPG-TETSQINLSDLKVSTLVRKPQPD FRNDGFSPKFNTSSSISSENSIIKGGAKNQALLHSKS-KQPKIRSIKCKHKENPVVAEPPVANEDCSLKCCSSDNK---G SPLASISKSGKVDGLKLLSNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKPSKPLLFSSASGQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRIMTAQNLVSYRSPGLGDCSTSSPVSAPKVLVSGGSNHSSEKSGDGTQDPVHPGPG G-GDSALSGELSTSLPGLGSDKRD---LPASGKNRSNCVTRRNCGRSKPS-KFRDGFSAQMGKNTVNRKALKTERRRKLN ELPAVTLEAALQGDRESRGSEKSSSRGEAEDPGKEPTLQLMGHLTSEDG-AHFSSVSFDNKVNQSDPEKIPEKGPSFEI- --RKVPELDSEMNSEN---DEPSSINEAVPKKRWQRLNQRRTKPRKRTNRFKEKENSEGAFGVLLSADPVKKE-DEFPEQ RPPASTNKLEDALTDPNHANHLDSAGPRLNVCDKSNASNEEMEKEPGIPSLTPQPELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKTQEQVHKVSSRCEEESLLARCRSS--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPA-------LESEELLVKPPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLTKKCYEAGHLENDINESCAAPRSKEFGG--GTTKLFDK-----------------------PRKRK RQRHATAKLHCKKVKNDISSKETPN-SEGELMTHRTAASPKETVEEGVENDHGMPASKKLQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICTTCHAAN------PASVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFTKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKKFKKKQQGKRRTQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLPPGPSTHLAEQ-SSGVAAQGPKMSDKPSADTNPSLSLSKKALAGTCQRPPLP-ERPPDRTDSRPQPVDR--- --VRDLAGSGTKPQSLVSSQKPLDRPPAVAGPRPQLSDKPS-PVTGPSSSPSVRS--------QPLERPLGTADPR---L DKSIGAASPRPQSLEKTPV-------------PTGLRLPPPEKL------------------------------------ ------------------------------------------------------LVTSGPKPQTSDRPPD---------- ------------------------------------------------------------------------KSHVSLSQ RLPPPDKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTPRQKDRAGSPHELTPQADEKMPV LESSSWPASKGLG----QIPRAVER-GSVSDAVLQPLGKAAATS-EHSWQAVKSLTQARLLSQPPAK-AFLYEPATQASG RAPAGAEQTPGPPSQAPGLVKQVKQ----MAGGQQLPGLAAKSG----QSFRPLGKS--SLSTEEK-----KLAPTEQSP WALG--KASPGPGLWPMVAGQTLAQSCWSSGSTQTLAQTCWSLGR-----GKD--PKPEQSTLPALNQAPSSHKCAESEQ K >Felis_catus_NSD1 ------------------------------------------------------------------MDQTCELPRRNCLL PFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTAS-GTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADG SESFQDPEKSDSRAQSPVVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQEPSCNNSPELQVKVTKTIKNGFLHFE NFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYEPKSENGVDVAMGNEQDSTSESRNGAVKSPFLPLAPQTE TQKNKQRNEVDGSNEKAALLPAPFSLGDTNVTIEEQLNSINLSFQDDPDSSTSTLGNMLELPG---TSSSSTSQELPFCQ PKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRRCVTSSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSMKKGHIQFEAHK------------------ ------EERRGKIPENLGLNFISGDVSDKQASNELSRIANSLTGSSTAPGNFLFSSCAKN-----TAKKEFETSNCDSLL GLSEGALISKHSGEKKKLQ------------------------------------------------------------- ---RGLVCSSK-VQLCYIG------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPIDHSSESDNSVLEITDAFDRTENILSV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKVKYTRYPATNTKVKAKQKSLITNSHTDHLMDCTKTGEPG-TETSQVNLSDLKVSTLIRKPQSE FRNDGFSPKFNTPSSISSENSLIKGGATSQALLHSKS-KQPKIRSIKCKHKENPVVVESSVTNEDCSLKCCSSDTK---G SPLASISKSGKVDGLKLLSNMHEKTRDSNDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKPSKPLLFSPASGQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGLGDCSTSSPVAASKALVSGSSTHNSEKNGDGTQNPVRPSPS G-GDSALSGELSVSVPSLVSDRRD---LPASGKSRANCVTRRNCGRSKPSSKLRDSFSSQMGKNTLNRKALKTERKRKLN RLPAVTLETALQGDRPSGGSENGCSRGGLEDPGKEEPLQLMGHLTSEDS-AHFSSVNFDDKVNQSNPDKIPEKGPSFEN- --RKGPELDTEVNSEN---DEPNGVNQAVPKKRWQRLNQRRTKPRKRTNRFREKENSEGAFGVLLPADPVKKG-DEFPEH RPPTSTNILEDALADPNHASCLDSVGPRLNVCDKSSASIEEMEKEPGIPNLTPQPELPEPAMRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARCRSS--AQNKRVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPA-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSKKCYEAGHLENDINESRAASHSKEFGG--GTTKIFDK-----------------------PRKRK RQRHSTAKVHCKKMKNDDSSKETPI-SEGELMTHRTAASPKDTVEEGVENDHGMPASKKLQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICITCHAAN------PASVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDDNPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFTKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLPPGPGTHLAEH-SSGVAAQGPKMLDKLPADTNQTLSLSKKALAGTCQRPPLP-ERPPDRTDSRPQPVDR--- --VRDLAGSGTKPQSLVSSQKPLDRPPAVAGPRPQLSDKPS-PVTGISSSPSVRS--------QPLERPLGTADPR---L DKSIGAASPRPQSLEKAPV-------------PTGLRLPPPDRL------------------------------------ ------------------------------------------------------LVTSGPKPQTSDRPPD---------- ------------------------------------------------------------------------KSHASLSQ RLPPPDKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLMDLTPHQKERAASPHEVTSQIDEKMPV LESSSWTASKGLG----QMPRAVER-GSVADPILQPPGKAAVPS-EHPWQAVKSLTQARLLSQAPAK-AFLYEPTTPASG RASVGVEQTPGPPSQAPGLMKQVKQ----MAGGQQLPGLAAKNG----QSFRPLGKAPSSLCTEEK-----KLATAEQSP WALG--KASPGPGLWPIVAGQTISPSCWSSGSTQTLAQTCWSLGR-----GQD--PKPEQNTLPALNQAPSSHKCAESEQ K >Canis_lupus_familiaris_NSD1 ------------------------------------------------------------------MDQTCELPRRNCLL PFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTAS-GTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADG SESFQDPEKSDSRAQSPVVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQEPSCNNSPELQVKVTKTIKNGFLHFE NFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNAICNYEPKSENGVDVAMGNEQDSTPESRHGAVKSPFLPLAPQTE TQKNKQRNEVDGSNEKAALLPAPFALGDTNVTIEEQLNSINLSFQDDPDSSTSTLGNMLELPG---TSSSSTSQELPFCQ PKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRRCVSSSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSMKKGHMQFEAHK------------------ ------EERRGKIPENLGLSFISGDVSDKQASNELSRIANSLTGSNTAPGSFLFSSCGKN-----TAKKEFETSNCDSLL GLSEGALISKHSEEKKKLQ------------------------------------------------------------- ---RGLMCSSK-VQLCYIG------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPIDNSSESDNSVLEITDAFDRTENMLSV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKVKYTRYPATNTKVKAKQKSLITNSHTDHLMDCAKTVEPG-TETSQVNLSDLKVSAVVRKPQSD FRNDSFSPKFNTPSSISSENSLIKSGATNQALLHAKS-KQPKIRSIKCKHKENPVVVEPPVTNEDCSLKCCSSDTK---G SPLASISKSGKVDGLKLLSNMHEKTRDSNDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKPSKPLLFSSASGQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGLGDCSSSSPVSASKVLVSGSSTHSSEKNGDGTQKSVRPSPS G-GDSALSGELSVPVPGLVSDRRD---VPASSKSHSDCVTRRNCGRSKPSSKLRDSFAAQMGRNTLNRKALKTERKRKLS RLPAVTLEAALQGDRVSGDSENGSSRGGLEDSGKEEPLQLMGHLTSEDS-AHFSSVHFDNKVNHPDPDKIPEKGPSFEN- --RKGPELDNEMNSEN---DEPSGVNQAVPKKRWQRLNQRRTKPRKRTNRFREKENSEGAFGVLLPSDPVKKG-DEFPEH RPPTSTNVIEDTLADPNHTSCLDSIGPRLNVCDKSSASVEEMEKEPGIPSLTPQPELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARCRSS--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLAQSELG------GGHAELPQLTLSVPV-APEVSPRPI-------LESEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDLGLSKKCYEAGHLENDS-ESRAASR--EYGG--GAAKIFDK-----------------------PRKRK RQRHATAKVHCKKMKNDDSSKETPG-SEGELMTHRTAASPKETVEESVENDHGMPASKKLQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICITCHAAN------PASVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDDNPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFTKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLPPGPGTHLAEH-SSGVAAQGPKMLDKLPADTNQTLSLSKKALAGTCQRPLLP-ERPPDRTDSRPQPVDR--- --VRDLAGSGTKPQSLVSSQKPLDRPPAVAGPRPLLSDKPS-PVTGISSSPSVRS--------QSLERPLGTADPR---L DKSIGAASPRPQSLEKTPG-------------PPGLRLPPPDRL------------------------------------ ------------------------------------------------------LVTSSPKPQTSDRPPD---------- ------------------------------------------------------------------------KSHASLSQ RLPPPDKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTPHQKERAASPHEVTPQVDEKMPV LESSSWTASKGLG----QMPRAVER-GSMSDPVLQPPGKTAVPS-EHPWQAVKSLTQARLLSQPSAK-AFLYEPTTQASG RAPAGVEQIPGPPSQAPGLVKQVKQ----MTGGQQLPGLAAKSG----QSFRPLGKAPSTLCTEEK-----KLATAEQSP WALG--KSSPGPGLWPMVAGQTISPSCWSSGNTQTLAQTCWSLGR-----GQD--PKPEQNTLPALNQAPSSHKCAESEQ K >Myotis_lucifugus_NSD1 ------------------------------------------------------------------MDQTSELPRRNCLL PFSNPVNLDAPEDKDSPFGNGQSTFSEPLNECTMQLSTAS-GTSQNAYGQDSPSCYIPLRKLQDLASMINVEYLNGSADG SESFQDPEKSDSRAQSPIVCTSLSPGGPT--------------------------------------------------- ------------------------------------------------ALAMKQEPSCNNSPELQVKVTKTVKNGFLHFE NFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYEPKSENGVDVAMGNEQDSTPESRHGAVKSPFLPLAPQTE TQKNKQRNEVDGSNEKASLLPAPFSLGDTNVTIEEQLNSVNLSFQDDPDSSTSTLGNMLELPG---TSSSSTSQELPFCQ PKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMK--VSNRRPY-----RQYYVEAFGDPSERAWVAGKAIV MFEGRHQFEEL---PVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCVSSSIKLDSEEDMPFEDCT ND-PESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSTDNPKRTCVKKGHMQFETNK------------------ ------EERRGKIPENLGINFISGDVSDKQASNELSRIANSLTGASTAPGSFLFSSCAKN-----PAKKEFETSNCDSLL GLSEGALISKRSGEKKKLQ------------------------------------------------------------- ---RGLVCSSK-VQLCYIK------------------------------------------------------------- --------------AGDEEKRSDSISICTTSDDGSSD--LDPIDHSSESDNSVLEITDAFDRTENMLSL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QKNEKVKYSRYPATNTKVKAKQKSLITSSLTDHLTDCTKTAESG-TETSQVNLSDFKVSTLVRKPQMD FRNDGFSTKFNTPSSICSENSLIKGGATNQTLLHSKS-KQPKIRSIKCKHKENP-VVEPPVTNEDCSLKCCSSDTK---G SPLASISKSGKGDGLKLLSNMHEKTRDSNDIETAVVKHVLSELKELSYRSLSEDVSESGTSKPSKPLLFSSASSQNHIPI EPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGLGDCSTSSPLGTSKVLVSGASNHNSEKNGDGTQDPVYPSPS G-GDSALSGELSASLPGLVSDRRD---LPASGKSRSNCVTRRNCGRSKPS-KLQDAFSGQMGKNTANHRALKTERKRKLN QVPAVIPEAALPGDRQNAASENGSLGGGAEDPAKEEPLQLMGHLTSEDS-AHFSDVHFDNKVNQSEPDKT-EKGSIFEN- --RKGPELDSEMNSEN---DEPSGVNQVVPKKRWQRLNQRRTKPRKRTNRFREKENSEGSFGVSLSADSVKKG-GEFPEH RPSPSTNILEDVLTDPNHTGHLDSVGPLLNVCDKSGANTEEMEKEPGIPTLTPQPELPEPAVRSEKKRLRKPSKWLLEYT EEYDQIFAPKKKQKKVQEQVHKVSSRCEEENLLARSRSN--AQNKQVDENSL-----------ISTKEEPPVLEREAPFL EGPLSHSELG------GGHAELPQLTLSVPV-ALEVSPRPP-------LKSEELLVKTPGNYESKRQRKPTKKLLES-ND LDPGFMPKKGDIGLSKKCYDAGHLENNIAESCGASHSKKFGGVIGTTKIFDK-----------------------PRRRK RQRHAIAKMHCKRVKNEDSSRETPG-SEGELMTHRMAASLKEAVEEGIENDHGMPASKKLQGERGGGAALKENVCQNCEK LGE--LLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGE------DVKRCLLPLCGKFYHEECVQKY PPTVMQNKG-FRCSLHICITCHAAN------PASVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTP- RRGCRNHEHVNVSWCFVCSE-----------------------------------------------------GGSLLCC DSCPAAFHRECLNI-DIPEG---NWYCNDCKA---------------GKKPHYREIVWVKVGRYR-WWPAEICHPRAVPS NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMG--KGVDGTYKKALQEAAARFEELKAQKELRQLQED RKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDDNPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFTKRQ YPEVEIFRTL-QRGWGLRTKTDIKK------------------GEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTL DKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAG-TELTFNYNLECLGNG-KTVCKCGAPNCSG FLGVRPKN------QPIATEEKSKKFKKKQQGKRRSQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRP AG-----------KWECPWHQCDI--CGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE YVPPPVPLTPGPNTHVAEQQSSGVAAQGPKMLDKPPAEANQTLSLSKKTLAGTCQRPPPP-ERPPDRTDSRPQPVER--- --VRTLAGSGAKPQSLVSSQKSLDRPSIVGGPRTQLSDKPS-PVTGPSSSPSVRS--------QPLERPLGAADPR---L DKSIGAASPRPQSLEKTPV-------------PTVLRLPPSDRL------------------------------------ ------------------------------------------------------LVTSSPKPQTSDRSPD---------- ------------------------------------------------------------------------KSHTSLTQ RFPPPDKVLS-------AVVQTLVAKEKALRPVDQNTQS----KNRAALVMDLIDLTSRQKERAASPHEATPQADEKMPV LESSSWLASKGLG----QMSRAVER-GSVSEPVLQPPGKAVAPL-EHPWQAVKSLTQARLLSPSPAK-AFLYESATQAAG RAPAGAEQIPGPPSQALGLVKQVKQ----MAGGHQVPGLVAKSG----QSFRPLGKAPSSLSTEEK-----KLATTEQSP WALG--KTSPGPGLWPMLAGHTLASSCWSSGSTQTLAQTCWSLGR-----GQD--PKPEQNTFPTLNQAPSSHKYAESEQ K >Callorhinchus_milii_NSD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------MDHIC----------------------------------------------------- -----------------------------EYEFTVG--------------------SSLPFSNQQRFSNSLGFSISE--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------SSGISYRTGQNDVCG-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------EECYN-----------------LQERSAVHLSPGFQDSTSPVLNGHGST SPYIPLR---------------KLQDLASMIPTRFS------------------------------------DSTEAR-Q WLDSPQDSVTQDCCVTD-KDSCSP-------------------------------------------------------- ------------------------------------------SESDSTPEVKLKITKMVMNG------------------ ---------------------------------------------KMMFESAICSEVETEDGKGS--------------- ---------------------------------DEQSP------------------------------------------ ---GIEDRE----------------------APVLP-------VLCHLRSSNRVWDLRERRRLLCDAERVG--------- --LEMVQDFRG------TRELKVEARSSFSSLMAASGSLLVEG----------TRAKAFSMATAEGKRQRKPSKKLLEST EDYDQLFIPKKKLKPGFDPLHQVCFIPDFVILDIVFDYKHIR-------------------------------------- ------------------------LLYLFSITENS---------------------------ERKRHRKPTKKLLES-TG DFDQFVPKKK-------------------------------------------------------------------FKR DLYHSFKSDIQP-----------------------------DSADEINDLDPFLSTSRKSQMERGGGAAKKENVCQLCEK PGE--LLLCEGQCCGAFHLKCLGLTKMPEGKFNCSECTTGFHTCFVCRQNGE------DVKRCLMPLCGKFYHMECIEKY PTSVALNKG-FRCSLHVCLSCHACN------PTNPRATKGRMMRCVRCPVAYHANDNCLAAGCVVLASNSIICTNHFTA- RRGCRHHGHVNVSWCFVCSE-----------------------------------------------------GGSLLCC ESCPAAFHRECLNI-EMPAG---KWYCNDCKA---------------GKKPRYKDIIWVKLGRYR-WWPAEVCHPKNVPT NIQKMKHEIGEFPVRFFGSNDYFWTYQARVFSYMEGDKGSKDKTC--KGLNSIFKKALQEAAERFEELKAQKETRQAQEE KRNEKKPPPYKHIKVNKAVGKVQIFTADLSEISRCNCKPTDENPCGQDSECLNRMLMYECHPAVCPAGEKCQNQCFTKRQ YPEVEILKTP-GRGWGLCCKGDIKK------------------GQFVNEYVGEVIDEEECYSRIKYAQEHDICNFYMLTL DKDRIIDAGPKGNYSRFMNHSCKPNCETQKWTVNGDTRVGLFALCEILSG-SELTFNYHLECLGTG-KTACKCGAPNCSG YLGVQPKN------APTSADMKKKPPIPR---KRKQQSELVKDHEEECFRCGDSGQLVICKKPGCPKVYHADCLNLNKRP AG-----------KWECPWHQCDV--CGKEAISFCELCPSSFCMDHREGALFISKLDGRLSCNEHDPCGPIPLEPGEIRE IMPSPN---------------------------------------------KLVLHALQPLDSTLIRSIVWDENLLC--- -------------------------------IRIQA-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Homo_sapiens_NSD2 -------------------------------------------------------------------MEFSIKQ-SPLSV QSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKA---QLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNG EPGAHDAKLRFESQ-------EMKGIGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDSAA------DVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDK---------------- ----------------------------------------KIPAKKES-------------------CPN---------T GRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERK--------------------- ---------------------AKFTFLYVGDQLHLNPQVAKEAGIAAES---LGEMAESSGV------------------ ------SEEAAENPKSVREEC--IPMKRRRRAKLCSSAETLESHP--DIGKSTPQKTAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADPRRGVGSPPGRKKT TVSMPRSRKGDAAS-QFLVFCQKHRDEVVAEHPDASGEEIEELLRS-------------------------QWSLLSEKQ RARYNTKFALVAPVQAEEDSG------------------------------NV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRNHTKRIQDPT EDAEAEDTPRKRLRTDKH-------------------------------------------------------------- --------------------------------------------------------------SLRK-RDTITDKTARTSS Y------KAMEAASSLKSQAATKNLS------------------------------------------------DACKPL KKRNRASTAASSALGFSKSSSPSASLTENEVS-DSPGDEPSESPYESADETQTEVSVSSKKSERG-VTAKKEYVCQLCEK PGS--LLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESK------TDVKRCVVTQCGKFYHEACVKKY PLTVFESRG-FRCPLHSCVSCHAS------NPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWFCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQES ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------STTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKP PPEPGKPKGKRRRRR-----GWRRVTEGK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Mus_musculus_NSD2 -------------------------------------------------------------------MEFSIRK-SPLSV QKVVKCMKMKQTPEILGSANGKTQNCEVNHECSVFLSKA---QLSNSLQEGVMQKFNGHDALPFLPAEKLKDLTSCVFNG EPGAHDTKLCFEAQ-------EVKGIGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDGAA------DVSQSEENEQKSDNKTRRNRKRSIKYDSLLEQGLVEAALVSKISSPADK---------------- ----------------------------------------KIPVKKES-------------------CPN---------T GRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQAEEAASMSIEERK--------------------- ---------------------AKFTFLYVGDQLHLNPQVAKEAGIVTEP---LGEMVDSSGA------------------ ------SEEAAVDPGSVREED--IPTKRRRRTKRSSSAENQEGDP--GTDKSTPPKMAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------AEPKRGVGSPAGRKKS TGSAPRSRKGDSAA-QFLVFCQKHRDEVVAEHPDASGEEIEELLGS-------------------------QWSMLNEKQ KARYNTKFSLMISAQSEEDSG------------------------------NG--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRSHTKRADDPA EDVDVEDAPRKRLRADKH-------------------------------------------------------------- --------------------------------------------------------------SLRKQRETITDKTARTSS Y------KAIEAASSLKSQAATKNLS------------------------------------------------DACKPL KKRNRASATASSALGFNKSSSPSASLTEHEVS-DSPGDEPSESPYESADETQTEASVSSKKSERG-MAAKKEYVCQLCEK TGS--LLLCEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKESK------MEVKRCVVNQCGKFYHEACVKKY PLTVFESRG-FRCPLHSCMSCHAS------NPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA- RKGKRHHTHVNVSWCFVCSK-----------------------------------------------------GGSLLCC EACPAAFHPDCLNI-EMPDG---SWFCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFNEVKLQREARETQES ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------SASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTEKP FPESLKSKGKRKKRR-----CWRRVTDGK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Callithrix_jacchus_NSD2 -------------------------------------------------------------------MEFSIKQ-SPLSV QSVVKCIMMKQTPEILGSANGKTPSCEVNRECSVFLSKA---QLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNG EPGAHDAKLRFESP-------EMKGIGTP--------------------------------------------------- ------------------------------------------------PHTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDSAA------DVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDK---------------- ----------------------------------------KIPAKKES-------------------CPN---------T GRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERK--------------------- ---------------------AKFTFLYVGDQLHLNPQVAKEAGIAAES---SGEMAESSGV------------------ ------SEEAAENSKSVREEG--IPMKRRRRAKQCSSAETLESEP--DIVKSTPQKTAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADPRRGVGSPPGRKKA TVSTPRSRKGDAAS-QFLVFCQKHRDEVVAEHPDASGEEIEELLRS-------------------------QWSLLSEKQ RARYNTKFALVAPVQAEEDSG------------------------------NI--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRNHPKRTQDPT EDLEAEDTPRKRLRTDKH-------------------------------------------------------------- --------------------------------------------------------------SLRK-RDTITDKTARTSS Y------KAMEAASSLKSQAATKNLS------------------------------------------------DACKPL KKRNRASTAASSALGFSKSSSPSASLTENEVS-DSPGDEPSESPYESADETQTEVSVSSKKSERG-VTAKKEYVCQLCEK PGS--LLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKENK------TDVKRCVVTQCGKFYHEACVKKY PLTVFESRG-FRCPLHSCVSCHAS------NPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWFCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQES ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGEVIDEEECMARIKHAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------STTLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKP PPEPGKPKGKRRRRR-----GWRRVTEGK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Rattus_norvegicus_NSD2 -------------------------------------------------------------------MEFSIRK-SPLSV QKVVKCMKMKQAPEILGSANGKTQNCEVNHECSVFLSKA---QLSNSLQEGVMQKFNGHDALPFLPAEKLKDLTSCVFNG EPGAHDTKLCFETQ-------EVKGIGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDGAA------DMSQSEENGQKSDNKTRRNRKRSIKYDSLLEQGLVEAALVSKISSPEDK---------------- ----------------------------------------KIPVKKES-------------------CPN---------S GRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQAEEAASMSVEERK--------------------- ---------------------AKFTFLYVGDQLRLNPQVAKEAGIATEP---LGEMVDSSVA------------------ ------NEEAAVDPGTMREED--IPVKRRRRAKRSSSAENQEGDP--GTEKSTPPKMAD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------AEPKRGVGSPAGRKRS TGSASRSRKGDSAA-QFLVFCQKHRDEVVAEHPDASEEEIEELLGS-------------------------QWSMLNEKQ KARYNTKFSLMISAQSEEDSG------------------------------NT--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------SGKKRTHTKRTDDPP EDVDVEDAPRKRLRTDKH-------------------------------------------------------------- --------------------------------------------------------------SLRKQRETITDKTARTSS Y------KAIEAASSLKSQAATKNLS------------------------------------------------DACKPL KKRNRASATASSALGFNKSSSPSASLTENEVS-DNPGDEPSESPYESADETQTEASVSSKKSERG-MAAKKEYVCQLCEK TGS--LLLCEGPCCGAFHLACLGLSQRPEGRFTCTECASGIHSCFVCKESK------MEVKRCMVNQCGKFYHEACVKKY PLTVFESRG-FRCPLHSCMSCHAS------NPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA- RKGKRHHTHVNVSWCFVCSK-----------------------------------------------------GGSLLCC EACPAAFHPDCLSI-EMPDG---SWFCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFNEIKLQREARETQES ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------STSLSSEEKSKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSANNTKTEKP FLDSLKAKGKRKKRR-----CWRRVTDGK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Equus_caballus_NSD2 MGASLFLISSHPLEFWHFHWLSLTGDCSCTVKTPHHHIAAREVFLKPPPSCTWASCGRRAMLQVVHVVAQQCCP-QLVHL QKVVKCIKMKQAPEILGNTNGKTQNCEVNRECSVFLSKA---QLSTSLQEGVMQKFNGHDALPFIPTEKLKDLTSRVFNG EPGAHDARLRFESQ-------EMKGIGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDGAA------TVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISGPSDK---------------- ----------------------------------------KIPAKKES-------------------CPS---------T GKDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV TFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERK--------------------- ---------------------AKFTFLYVGDQLRLNPHVAKEAGIAVES---LGEMVESSGV------------------ ------TEEAAYNSKPMREEG--IPIKRRRRAKLPSSAENQESDP--GTVKTTPQKTAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------GDSKRGVGSPSGRKKA TASTPRSRKGDAAS-QFLVFCQKHRDEVVAEHPDASSEEIEELLGS-------------------------QWNMLNEKQ KARYNTKFALVASSQSEEDSGSSLKSFGEA----KRKVFQDSPKRRPRPRSNL--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRNHTKRTQDPT EDVEVEDAPRKRLRTDKQ-------------------------------------------------------------- --------------------------------------------------------------GLRK-REMITDKTARTSS C------KAIEAASSLKSQAATKHLS------------------------------------------------DACKPL KKRNRASAAASSALAFSKSSSPSASLTENEVS-DGQGDEPLESPYESADETQTEVSVSSKKSERG-VTAKKEYVCQLCEK TGS--LVLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHTCFVCKENK------TDVKRCVVSQCGKFYHEACVRKY PLTVFESRG-FRCPLHSCVSCHAS------NPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWFCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQEN ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------STSLSSEEKGKKTKKKTRRRRTKGEGKKKSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTSFCHFCPNSFCKEHQDGTAFSSTQDGRSYCCEHDLGAESVRSAKTEKP FPEPMKSKGKRKKRR-----CWRRVTEGK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Monodelphis_domestica_NSD2 -------------------------------------------------------------------MNFSIRRNSPSLT QKIVSQLKMKQVPEILGNTNGKTQNCEVNRECSVFLSKA---QISTTLPEGVMQKFNGHEALPFIPAEKLKDLTSRVFNG ESGAQDAKLRFESQ-------EIKGIGTP--------------------------------------------------- ------------------------------------------------PHTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDNGP------DVSQSEENEQKLENKSRRNRKRSIKYDSLLEQGLVEAALVSKASSPSEK---------------- ----------------------------------------KILAKRES-------------------YPN---------I NKEKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV SFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGKLRTQWEMGIIQAKEAVSMTVEERK--------------------- ---------------------AKFTFVYVRDRLHLNPQVAKEAGIAVDP--LEEIE-ESSDM------------------ ------SEETAQNLK-HKELG--VPIKRRRRSKLLSCTDNLESDS--GPKNITPQRAAEQ-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADSKRGLGSPVGRKKA AASTPRSRKGDSGS-QFLVFCQKHRDEVVAEHPDASSEEIEELLES-------------------------QWNMLNEKQ KARYNTKFAIVTSPKSEEDSGSSLKNIGDT----KRKVFQDSPKRRSRSRSNL--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------HGKKRNNTKRTQHPT EDFEVQEPPRKRLRMDKQ-------------------------------------------------------------- --------------------------------------------------------------NNRK-RETSNDKATKTNS S------KVTETSSSLKNQSATKNLS------------------------------------------------DACKPL KKRNRASATESSTLAFSKSSSPSTSLTENEIS-DGQGDEPSESPYESADETQTEISISSKKSERG-TTAKKEYVCQLCEK SGN--LLLCEGPCYGAFHLSCLGLSRRPEGKFICSECTSGIHSCFVCKEKK------TEVKRCVVSQCGKFYHEACVKKY HLTVFESRG-FRCPLHSCVSCHVT------NPSNPRSSKGKMMRCVRCPVAYHGGDGCLAAGCSVIASNNIVCTNHFTA- RKGKSHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWYCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGI-KGIGKVFKNALHEAEARFREIKLQREARETQEN ER---KPPPYKHIKVNKPCGKVQIYTADVSEIPKCNCKPTDENPCGFDSECLNRMLMYECHPQVCPAGEQCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIKK------------------GEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKN------SAALSSEEKGKKTKKKTRRRRTKGEGKKESEDDCFRCGDGGQLVLCDRKCCTKAYHLSCLDLVKRP FG-----------KWECPWHHCDV--CGKPSVSFCHFCPNSFCKEHQDGTVFSTTQDGRLCCSEHDFGVESIRNPKTEKP FPEPTKLKPKRKKRR-----CWRRKTECK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gallus_gallus_NSD2 -------------------------------------------------------------------MDFSIKRSSQLLT RKIN-YLKMKQVPEILGNTNGKTQNCEVNRECSVYLGKA---QLSATLQEGVMQKYNGHDALPFIPADKLKDLTSRVFNG ESGAQDAKLRFEPQ-------EIKGVGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDNGA------DVSQSEENEQKTTNKERRNRKRSIKYDSLLEQGLVEAALVSKTSSSPEN---------------- ----------------------------------------KAPAKRDS-------------------TQST--------I KDDKVHLLKYNIGDLVWSKVSGFPWWPCMVSADPILHSYTKLK--GQKKSF------RQYHVQFFGDAPERAWIFEKSLV PFKGKDQFEQLCQESAKQALTKAEKIKMLKPVPGKLRPQWEIGVKQASEAVGMTVEERK--------------------- ---------------------AKYTFIYIRDRPHLNPQVAKEVGIAVEL--LEEEVDESSYS------------------ ------NEETSENLKSMKESG--IPNKRRRRTSKLSATDDTQESSQLETKNTTPQKSSEQ-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------AESKRGIGSPLSRKKT PASTPRSRKGDAVS-QFLVFCQKHRDEVVAEHPDASSEEIEELLES-------------------------QWNMLSEKQ KARYNTKFAIVTSPKSEEDSGSSLKNIGEA----KRKVFQDSPKRRSRSRSNL--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------HGNKRNQKKRTKEPT EDFEVQEAPRKRLRMDKQ-------------------------------------------------------------- --------------------------------------------------------------NNRK-RETSNDKTAKTNS T------KVTETSSSQKNQSATKNLS------------------------------------------------DACKPL KKRNRASAAESSTLAFSKSSSPSASLTENEIF-DGPGDERSESPYESADETQTEVSISSKKSERG-TGTKKEYVCQLCEK TGD--LLLCEGLCYRAFHVSCLGLSGRPAGKFVCSECTSGVHTCFVCKERK------ADLKRCVVSHCGKFYHEACVKKF HLTVFESRG-FRCPLHSCLSCHVS------NPSHPRISKGKMMRCVRCPVAYHAGDVCIAAGCAVIASNSIVCTNHFTA- MKGKSHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWYCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYFWTHQARVFPYMEGDRGS-RYRGI-KGIGKVFKNALQEAEARFREIKLQREAKETQES ER---KPPPYKHIKVNKPCGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMYECHPQVCPAGERCQNQCFTKRE YPETEIIKTD-GKGWGLVAKRDIKK------------------GEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCKCGAPNCSG FLGDRPKN------SSTNASEEKGKKTKKRTRRRRTKNEGKKESEDDCFRCGDGGQLVLCDRKSCTKAYHLSCLDLVKRP FG-----------KWECPWHHCDV--CGKPSVSFCHFCPNSFCKEHQDGTVLNSTLNGQLCCSEHVLGVDSVETQKTEKP RKKLNKLKPKRKERN-----RWMR-AECK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Anolis_carolinensis_NSD2 -------------------------------------------------------------------------------- ----------------------------------------------------MPKYNGHDALPFIPADKLKDLTSRVFNG ESGTQDSKLHFESR-------DIKEAGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDNGI------EVPQVEESEKKTSNKERRNRKRSNRYDSLLEQDFVEASSVSNASSAENRG--------------- ----------------------------------------KKREEKRN-------------------TPN---------- NFTDHHLLRYHIGDIVWSKVSGYPWWPCMISTDPLLHNFTKLN--GQKKSF------RQYHVQFFGDSPERAWVFERSLA PFKGEEQFEQLCQESAKHSLTKADKIKMLKPVSGKLRPQWEMGVKQAKDALSLTMEERK--------------------- ---------------------TKYTFIYIRGRPLLNPQVAKEAGLVVKS----LEEMDKIYT------------------ ------DEDISKSLKSRKGHD--IPAKRRRKTKLLVMTESEEDFMHAKNIGMSDKSSNSE-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------KDLEEGEG------KR VSGSPISRKGDAVS-QFLVFCQKHRDEVVAEHPEAATDEIEELLES-------------------------QWNMLSEKQ KARYNTKFAIMTSPKSEEDTG------------------------------NL--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------HGNKRKPIKRTKKHT EDFEVEEAPRKRLRMDKR-------------------------------------------------------------- --------------------------------------------------------------NYRK-RERSNDKPEKTYS S------KVTETSS----QKNQSGLS------------------------------------------------DACKPL KKRNRASAAESSHLGYSKSSSPSVSLIENEIS-DSLGDERSESPYESADEALAEISQS-KKSDRG-AATKKEYVCQICEK PGE--LLLCEGRCFGAFHAGCTGLSAKPVGHFICTECSSGIHSCFVCKEKK------PEVKRCIVSHCGKFYHETCVKKF HLTVFENRG-FRCPLHSCVSCHVT------GPSNPKVSKGKMIRCVRCPIAYHASDACVAAGCAMITSSSIICTNHFTA- KKGKSHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWYCNDCKA---------------GKKIHFQDIIWVKLGKYR-WWPAEVCHPKNIPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGI-KGIGKVFKNALQDAEARFREIKFQREAKETQEN ER---KPPPYKHIKVNKPFGKVQVYTADISEIPKCNCKPSDENPCGFDSECLNRMLMYECHPQVCPAGERCQNQCFTKRQ YPETKIIKTD-GKGWGLIAKRDIKK------------------GEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVHGDTRVGLFAVCDIPEG-TELTFNYNLDCLGNE-KTVCKCGAPNCSG FLGDRPKN------SSSNASEEKGKKTKR-IRRRKTKNKARKKTEDYCFRCGDGGQLVLCDRKFCTKAYHLSCLDLIKRP FG-----------KWECPWHHCDV--CGKLSVAFCHFCPNSFCKDHQDDAVLDSNLNGQLFCTDH--IEENFTEKKMKRT ARKMITLKSKRRQRN-----KWKKQHTCGKL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Callorhinchus_milii_NSD2 -----------------------------------------------------------------MAQPCRFIGNPLPLA QDLLNPISMKQVPEILGIANRKSQNGEMDSEHSLLPDKTAT-QLSAALQDGVMHRLNGHDATSAYRSDKLKDLTALMLNG DSGAVQEPLSVQASSPVDCSIENRGSETP--------------------------------------------------- ------------------------------------------------PHTTPKK---SGSPEIKLRITKTYLNGKPLFE SSLCGDLQIDDPEIIEHQQNVEEKEENQERRKRKRKRSVKYDALLEQNLAEVALVSKTSNTPDAD--------------- ----------------------------------------EKIAKEDL-------------------EEEEERDEETKEK DKEKDVPVKYNVGDMVWSKVSGYPWWACMISSDPLLNTHTKVK--GLNRAIG-----RQYHVQFFGEAPERAWIFEKSIV PFEGAQQYDQLIQDCAKHATSKAEKNKLLKPIPAKIRVQWDVGISQAEEALMMTPEDRK--------------------- ---------------------AKYTFVYDHDRPLLPPQVAKETGVPVERIEGRKYPAEESLS------------------ ------TKENFADSRGSRKRNSSVPNKNRRCSKPSESQKTPTKQCINRTVEPSEGSPSERTVC----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------RSSDSESGTGSPMTKRKS GAPTQRIRKCDTAFAQFMAFCQKHRDELAEEHPDASSEEIEELLES-------------------------QWAMLSDKQ RARYNTKFSLVTPVTDHKSPAASGFSAASPGATRRKVLQDSPKRTTRSSVSSD--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------STRQRRLSRKIVDYR EDSPERIGSNRRLKRDYY-------------------------------------------------------------- --------------------------------------------------------------EDEKYDSNNANQTEASVS DGIEAGETSSVVNAPQNSQSDISKLS------------------------------------------------DACKPL KKRSRASTTETLAPAVSKNPSPLTVFTENETSFDGQLESADESADETPTEASSVSSKKSQGERGGSAAAKKESVCQVCEN AGE--LLFCEGQCCGAFHLTCLGLSKMPQGKFMCSECLSGVHTCFVCKKNG------PDVKRCIVPLCGKFYHEDCVRKY PPTVFENKR-FRCPLHSCISCHATNAT---NPSNPRVTKGRMMRCVRCPVAYHGGETCIAAGSVVLAANSIICTSHFVP- KKGYSHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPECLNI-DMPEG---SWYCNDCKA---------------GKKPHYKDIIWVKLGSYR-WWPAEICHPRSVPT NIQNMKHEIGEFPVHFFGSNDYFWTHRARVFPYMEGDKGC-KDNKI-KGLSKAFKKALQEAGDRFQDLKAQRETREAQEN ERNGRKPPPYKPIKINKSFGRVQIYTADISEIPRCNCKPTDDNPCGLDSECLNRMLMYECHPSVCPAAGQCQNQCFTKRQ YPETQVVKTV-GKGWGLISKTGIKK------------------GVFVNEYIGEVIDEDECRARIRFAQEHDIANFYMLTL DKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGETRVGLFSVCDIPAG-IELTFNYNLDCLGNE-KTICKCGAPNCSG FLGVRPKT------ASN-GSDDKGKRGKKKIRKRKTKHEGRKEHEDECFRCRDGGQLVLCDRKICSKAYHLSCLSLTKPP FG-----------KWECPWHHCDV--CGKLSVVFCQFCPNSFCKDHQKETVFKSKLDGRPCCSEHDHCNTAEPLEQCKKM ETVLSLKDTVKSES------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Danio_rerio_NSD2 --------------------------------------------------------------------MTDSKGGSLPAM PEPKSPTSMKQLSDSPGGRN---GLVDGITDPTML-MNKAATQLAATPQESVPQMIGSHGHN--HTHEHLKDLTSRLLNG DTEKIPKLCAAPAG-----QPLLKGVEPV--------------------------------------------------- ------------------------------------------------SQHASPPRKTSVSPELTVKITKCVVNLGGKPN RYEVDYTEEK----AEETDAPLRLPEGVLTSPTARRDRQKKKGMVRKRIPPYPILTHAASSDQSPLLHPTINSNDITIEP CGLPVESIEHTHGDMPTCVTAFPDEQPLSDCEETVDAQGVDETDDAQG-------------------ENDVKE------S YTETQSNVHFSVGDVIWTKVSGYPWWPCMITTDPEFNMHFRSK---VNSRTG-----LLYHVQYFGDTPERGYVFEKCIV TFSGKHQYQSLSRSNQLP-INISGRKR---AVPRKFRQKWEIGVSQAKEALGLLTEERL--------------------- ---------------------AKFSFVYEDGKAQLNPHMLQVLEEQRNQ----GLQEEPVQR------------------ ------EPQELVSLTPPDSTHSSPTNSSTTSTIPSLFSNPIDSSTSSGKTALPRKARKPS-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------VKTNRRKQRSSTIEWI VTEASSAKQMPLTESTVQCEVNTEHKKKGKTNAGKRPYRKKDLLCIDLDLQPKASQKKPRHIRQKFPAAPNSVKKRKIKA GVSICDTLNTVSTSAGLSEVK-------------------------------A--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------SAPSTKLWEKEDASS KGMKKVCKRSRESKQDVTL------------------------------------------------------------- ----------------------------------------------------QPKKKSKLEKDFKKWKCPKAASSAPAAV PAPRGRRRKTDRDENRKRSKKASK------------------------------------------------EEPPPKAK RGRKRKEESGRQSFP-ASKKCRPSSYAEPE---------RPDSPSDSTDESHP-----SKKAERT-PGAKKESVCLVCEQ TGE-DIVTCAGQCYGTYHLHCIG-VERSAEKILCTACSTGVHVCFTCKKSE------GEVRRCCALHCGRFYHEACVRLS ALTVFENRG-FRCPLHTCLSCHYS------GRAACKATKGKMMRCLRCPVAYHVGDLCVAAGSEMISSSAIVCTNHFRA- KKGYSHHSHVNVSWCFICSK-----------------------------------------------------GGRLLCC ESCPAAFHPDCLNI-AMPDG---SWFCNDCRS---------------GKKPKYRDVIWVKLGNYR-WWPAEIRHPKNIPT NIQHLRHEIGEFPVFFFGSKDYFWTHQGRVFPYMEGDRGS-KYQ-Q-TGIGKVFKNALLDAETRFKEIEMEREAKEAHEN NK---KPPPFKYIKVNKPCGRVQVYTADISEIPKCNCKPSTERPCSFESECLNRMLLYECHPQVCPAGERCQNQDFTKRL YPETKIIRTA-GKGWGLISLRDIKK------------------GEFVNEYVGELIDEEECRSRIRHAQENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGAPNCSG FLGDRPKN--------GHTSEPKAKLQKKKPKRKRARNEG-KKSEDECFRCGDGGQLVLCDKKGCTKAYHLSCLDRTKRP FG-----------RWDCPWHHCDV--CGKNSAAFCQLCPNSFCKAHQEGALRSHPLTGQLCCQEHEDSDIRPQTETAQLP P----PTKPRKYRRRAEAKTTSKAPLKKRPRKNAEV-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Takifugu_rubripes_NSD2 ---------------------------------------------------------------------MDSKGSSLPSM PEPANPVSMKQLPEPLSVRK---NGGDMSSDHSML-MDKAAAHLAATLQDSVLQKMASHSHG-NHSHERLKDLTSLVLNG DQD-TLPKLSTPE------QPLLKSAEVP--------------------------------------------------- ------------------------------------------------TTNGTHQHNCSSHSEPELKVTVPQVVTQQPPF QPSSVNGTSL----ATTTESTVRTPEKREDAKKRRGRPHKEKPQASLRPAPVPAEPLHSVNAKD---------------- ----------------------------------------ASGAVGEP-------------------DLKPEA------K HKESPLLITLSVGDLVWTKVSGYPWWPCMVTTDPNFNSHFKQKQKASSSKTG-----VLYHVQYFGDAPERGYVFEKNTV PFTGEDQYHDLCQCKKPP-ASRSAHKKMAPSVPRKFRAQWNMGIIQAKEALNMPVEERM--------------------- ---------------------ANFLFLYDDKGPRLNPHIMEKLKPEASL----DRDPEFRAQ------------------ ------PDLPSQPADPLGDLTAQFSNSTSAEMKGAVSSKEMLHPPAETQDPLSSAAEAQA-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------DTSQEIKGS----EQT QSAKKTVRRKKSAAENSSDPVKKKRKTAQSRPTEDAPESFSVT-----------------------------GQGVKKRQ KKNIPAKQ--RTDS-AAEQDP-------------------------------K--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------TSPERPLSGEAAVKG PGLKKRRKINKEAEKEA--------------------------------------------------------------- ------------------------------------------------------------------------GSSEENSK KRRR-NKPEKDATGTQKQQKKAAELL--------------------------------------------TDDQNAEKPK RKRKRRQDGENQAAASKAKKRRLSPCPDPEVS---GGEERPDSPIDSLDG--------TKKGER-----KKEFVCQSCEK AGE-DLVPCEGQCCGMFHLQCLG-MMELEDKLLCQECSTGVHSCFHCKKSE------GSVRRCHVPHCGKFYHEACIRLN PLTVFDNKG-FRCPLHTCLGCCCS------SRTKHKPSKGRLMRCLRCPVAYHAGDLCVAAGSEMVTSTAIICTNHFNA- KKAYRHHSHVNVSWCFVCSK-----------------------------------------------------GGQLLCC ESCPAAFHPDCLNI-AMPDG---SWFCNDCRA---------------GKKPKYRDIIWVKLGKYR-WWPAEIHHPRNIPT NIQHLRHEIGEFPVFFFGSRDYFWTHQGRVFPYMEGDRGS-KYQ-R-TGIGKVFKHALLEAEARFKEIKMKREKKEAQQY SR---KPPPYKFIKVNKPVGKVQVYAADVSEIPKCNCKPSDERPCGFESECLNRMLQYECHPQVCPSGERCGNQDFTQRL YPDTKIIKTP-GKGWGLITLRDIKK------------------GEFVNEYIGELIDEEECRARIKYAQENNVTNFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAICDVPAG-TELTFNYNLDCLGNE-KTACCCGAPNCSG FLGDRPKN------SNGHAAEPKAKRGKRKYKKRKSEGR--KKSEDECFRCGDGGQLVLCDKKTCTKAYHLSCLNLTKRP FG-----------RWDCPWHHCDV--CGKNSEAFCQLCPNSFCKCHQEGALRPSPVTGQLCCQEHEELDVPTSPGRDDGS E----TNTTSPAGTDGRPPKGSNARTKSSKRKAE---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Tetraodon_nigroviridis_NSD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------ITLSVGDLVWTKVSGYPWWPCMVTSDPEINCHFKQKQKASSSKTG-----ALYHVQYFGDAPERGYIFEKNMV PFTGEDQYQDLCQCKKKP-ASRSVHKKMAPSVPRKLRAQWNMGIIQANEALSMSVEERM--------------------- ---------------------ANFLFLYDDKGPHLNPHIMEKLKPEPGL----DHGAGLRLQ------------------ ------PDHRSPPADPLGDLTAHFSNSTSAALQPQPDAQSTPFTCSCSQDPHAAAASPAD-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------APQKKRRRS----KQA QTPQKTARRKKSAAENSSDPVKKRRKSKPSPSAEEAPGSVSAAPSVPGQWEVEPQQSPVRQRGAKSDLLACSGEGVKKRQ KKSLPDKQ--RTDSTGLLQTK-------------------------------K--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------LSLRRPLSDDTAEKG PGVKKRRKMNKEAEKEVR-------------------------------------------------------------- ----------------------------------------------------------SVCSDFCSQCVSKAGTSEESGK KQKR-RRRKLERNATEKPLKNPAD------------------------------------------------DQDAEKPK RRRKRKQDGENQAPASKAKKRRSSPCPEPEVS---GSEGRPDSPSDSLDG--------TKKGER-----KKEFVCQSCEE AGE-DLVPCEGQCCGMFHLQCLGVLLEPDDKVLCQECSTGVHSCFHCKKSE------GSVRRCHVPHCGKFYHEACIRLN PLTVFDNKG-FRCPLHTCLGCCYG------NRTKPKSTKGRLMRCLRCPVAYHAGDLCVAAGSEMVTSAAIICTNHFNA- KKAYRHHSHVNVSWCFVCSKVP---------------------------------------------------GGRLLCC ESCPAAFHPDCLNI-AMPDG---SWFCNDCRA---------------GKKPKYRDIIWVKLGKYR-WWPAEIYHPRNIPT NIQHLRHEIGEFPVFFFGSRDYFWTHQGRVFPYMEGDRGS-KYQ-R-TGIGKVFKHALLEAEARFKEIKMKREKKEAQQY SR---KPPPYKFIKVNKPVGKVQVYAADISEIPKCNCKPSDERPCGFESECLNRMLQYECHPQVCPSGERCCNQDFTQRL YPDTKIIKTP-GKGWGLITLRDIKK------------------GEFVNEYIGELIDEEECRARIKYAQENNITNFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPAEGTELTFNYNLDCLGNE-KTVCCCGAPNCSG FLGDRPKN------SNGHTAEPKAKRGKKKYKKRKSEGK--KKSEDECFRCGDGGQLVLCDKKTCTKAYHLSCLNLTKRP FG-----------RWDCPWHHCDV--CGKNSEAFCQLCPNSFCKSHQEGALRPSPLTGQLCCQEHEELDVPPGQVTTPLG V----EAKPLRLHRRASPTKTSFKRPGKPKRSLKV--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gasterosteus_aculeatus_NSD2 ---------------------------------------------------------------------MESKGSSLPTM PEPANPISMKQPPESLGVRQ---AGGDMSGDPALLMMDKAAAQLAATLQDGVLQKMAGHSHN-NHGHERLKDLTSRVLNG DQD-ALPKLCAPE------PPMFKGAEAP--------------------------------------------------- ------------------------------------------------ATNGTHQHTCSPHADHEHKATIPQVVQQ-PAF EPRCANGTSL----STAT------EDAVSAMEPERLMRFFFYSYFKETKVLYFIPLISSL-------------------- -----------------------------------------LQPDFPP-------------------PLKGVD------P REESAAVVGFSVGDLVWTKVAGYPWWPCMVTTDPEFNNHVKQKQKAANSRMG-----PLYHVQYFGDAPERGYIFEKNMV TFTGEDQYQELRQGRQQP-ASRVVLKRTAPSVPRKLQAQWNMGVIQAKEACGMSLDERM--------------------- ---------------------GNFAFLYDDDGPHLNPCILEKSPKK---------------------------------- -------ALRRGKRHKDAEQNSARENIGERAK---------------------AIEAETV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------VPEKKKRRP----RQA ASPA----KTVGRRNNTSEPVK-KRKPKVASLTADVTEPVPLPLS----------------GWFPVKSPALNGHMWLVKR QRGFIVVE--QLYSRGSERRR-------------------------------L--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------QRTKLSSLKRDVKQA KKLKHRSKSPNESLTLSEV------------------------------------------------------------- ----------------------------------------------------W----NGVKYQHQMDNKHIVDSSEGTDK KQRR-QKPDGDSKEPKKKKKTTAKLKALLPGKPRAPTSSSKLF-------------------------VFTENQDAEKPE RSRKRKQDGGNASAPSTAKRRRLTPCPEPEGS---GSEGRPDSPSDSLDG--------TKKGDR-----KKEFVCQTCEQ AGD-DLVPCEGQCCGMFHLRCLGLSLKPDEKLLCQECSSGVHSCFTCKQSE------GAVRRCHVPHCGRFYHEACIRLS PLTVFDNKG-FRCPLHACLSCHYG------CRSKQRSTKGRLTRCLRCPVAYHAGDPCVAAGSEMVTSTAIICTNHFNA- KKGYSHHSHVNVSWCFVCSK-----------------------------------------------------GGQLLCC ESCPAAFHPDCLNI-AMPDG---SWFCNDCRA---------------GKKPKYRDIIWVKLGKYR-WWPAEIHHPRNIPT NIQHLRHEIGEFPVFFFGSKDYFWTHQGRVFPYMEGDRGS-KHQ-K-TGIGKVFKNALLEAEARFKQIKLKREAKEAQEN SR---KPPAYKFIKVNKPVGKVHVYTADVSEIPKCNCKPADERPCGFESECLNRMLQYECHPQVCPSGARCCNRDFTKRL YPETKIIKTP-GKGWGLISLRDVKK------------------GEFVNEYIGELVDEEECRARIKYAHENNISDFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVRDIPAG-TELTFNYNLDCLGNE-KTVCRCGAPNCSG FLGDRPKN------SSSQTAEAKAKRSKRKYRRRKAEGQ--KKSDDDCFRCGDGGQLVLCGKKTCSKAYHLYCLNLNKRP FG-----------RWDCPWHHCDV--CGKNSEAFCQLCPNSFCKAHQEGALRSWPPTGQLCCLEHEEQPEGPG-APDPGA VIAALQATPPAPDAGSRPAK------SSRKAGGVEGK------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gasterosteus_aculeatus_NSD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------FFSLLLSGVHTCFVCKTSGS------GVKRCIIPLCGKFYHNDCILAY SATQPHNKG-SRCPLHVCLSCHITN------PLNICSTKGRLARCVRCPVAYHANDNCMAAGSLVLANNSFLCPNHFTP- RKGCKNHEHINVSWCFVCSE-----------------------------------------------------GGSLLCC EACPAAFHQECLNI-EMPQG---SWFCNDCKA---------------GKRPRIKDILWVKWGRYR-WWPAEVCLTRDVPD NILRMKHEVGEFPVQFFGSKDFVWTYQARVFPYMEGDTHNIEKMG--KGADAIYKNALTDAAERFRELKAEKEMKQLQED RKNDKKPPPYKHIKVNRPIGKVQIFTADLSEIPRCNCKASDENPCGIDSECINRMLMYECHPQVCVAGERCQNQAFTKRQ YTPVEIFRTL-SRGWGLVGVSDIKK------------------GAFVSEYVGEVIDEEECRARIRHAQENDISNFYMLTV DKDRIIDAGPKGNQARFMNHCCQPNCETQKWTVNGDTRVGLFALQDIPKG-VELNFNYNLECLGNG-KTACKCGAPNCSG FLGVRPKN------QPSAEKLK--EGKRKVPMKKKTKQEVTKEREDECFSCGDGGQIVSCKKPGCPKVYHADCLNLAKRP AG-----------RWECPWHQCDV--CGKEAASFCEMCPSSYCKEHREGMLFISKLDGKLSCSEHD-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Oryzias_latipes_NSD2 ---------------------------------------------------------------------MDGKGSSLPSM PEPANPVSMKQPPESLSVRK---ALGDVTSDPALL-MDKAAAQLAATLQDGVLQKMAGHNH---HTHEKLKDLTALVLNG DQDAVLPQLCAPE------PPMFKGAEAP--------------------------------------------------- ------------------------------------------------TATGPHQLNGTAHAEPELTVSVPQVVQQ-PSL EPYCANGVGL----VTEDT--LSGPDGRHEVKKRRGTANKPKAQVNSTFVLPVDHENTGE-------------------- -----------------------------------------EPAVAQP-------------------ALMSAL------P GGECPSRTRFCPGDVVWTKVSGYPWWPCMVTNDPEFNSHFKEKQKAVTCELD-----ILYHVQYFGDAAERGYVFERNMV SFSGEEQYPELCQGIRLP-GSCVTHRKTSASVPQKLQAQWNMGVIQAKEALCMPPDERL--------------------- ---------------------ENFGFLYNEEGPQLNPHILEKLKPE---------------------------------- -------DCDDGVLDGQARLLSD-PNSSSSSD---------------------SLAEP---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------VAQKKRRRP----RQA QTKAD-KRKSKCAASRTRDPVKTKRKPKLPSSTEDRLG--------------------------------------TVRR ERRKRSKR--PQAGAAADRDQ-------------------------------P--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------PRRRRSALKDPEKQA S------------------------------------------------------------------------------- -------------------------------------------------------------------------TSEGPNK RRRK-TRDGGEAR--KRADKSQPRLQ---------------------------------------------EDQSTEKPK RRRKRKQDG--EMKTSKAKKRRSSPCPDAEGS---GSEERPDSPSDSLDG--------TKKGEK-----RKEFVCQVCEQ AGE-DLVPCEGQCCGMFHLHCLGPSFKPEDKLLCQQCRAGIHSCFACKQSE------GEVRRCHVVHCGKFYHEACIRLN PLTVFDNKG-LRCPLHACLSCHYG------SRTKHKSTKGRLMRCLRCPVAYHVGDLCVAAGSEMITNTAIVCTNHFNA- KKGYSHHSHVNVSWCFVCSK-----------------------------------------------------GGQLLCC ESCPAAFHPDCLNI-AMPDG---SWYCNDCRA---------------GKKPRYRDIIWVKLGTYR-WWPAEIQHPRNIPT NIQHLRHEIGEFPVFFFGSRDYFWTHQGRVFPYMEGDRGS-KHQ-R-TGIGRVFKNALLEAEARFKEMKMKREAKEAQES SR---KPPPYKFIKVNRPYGRVQVYTADVSEIPKCNCKPTDERPCGFESECLNRMLQYECHPQVCPSGERCCNQDFTKRL YPETKIIKTP-GKGWGLVALRDIKK------------------GKFVNEYIGELIDEEECRARIKYAHENNITNFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCHIPAG-TELTFNYNLDCLGNE-KTICRCGAPNCSG FLGDRPKN------SNGHAAEPKGKRPKRKYKKRRSEGK--KKSEDECFRCGDGGQLVLCDKKTCTKAYHLSCLNLTKRP FG-----------RWDCPWHHCDV--CGKNSEAFCQLCPNSFCKAHQEGGLWPRPPGGELCCLEHDELEGANGPAHDPGS VGGAAAPAPLSRSRGSRKADRPGGRTKSSKRKAAEA-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Lepisosteus_oculatus_NSD2 -------------------------------------------------------------------MDLNAKGSSLPLM PEHLSPVSMKQAPEALSSRKSQAAGVEMSADPAILMDKAAAAQLVATLQDTVIQISG----------ERLKDLTSRVLNG DQD-KLPKLCAAEP-----PPLLKGGDPP--------------------------------------------------- ------------------------------------------------TPHASPPKKGD-SPEIKLKITKTVANGKPRFE SCFCEDGEVP----AAAAAPAAQKRKERENKGRKRRRRLVRAEPRRRPLLAPAASSPASVASGSGAGTACKVG------- ---------------------------------HSSFSTPPLASSSVS-------------------PVQEPL------K DSEGELPGKFSVGDVVWTKVSGYPWWPCMVTKDQALSSHIKLK--AVNSRTS-----VQYHVQFFGNAPEHGYIFEKSIV PFGGEQQYRELCQESARPCAARSDKKKLPKSVPAKLRAQWEIGITQAKEAAGMETRERL--------------------- ---------------------AKFTFAYVNGRPQLSPRVLGELGLEE-R----DPAALPRAC------------------ ------QESAALPPEPPGPPAAPHRRSTSWTKR----------TPTIKAPGRIRAGKGRQ-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------WPLKKRKEVS---TVS KQKEDQAQPDDQAVAESLDVSKENGKDSLAPKLKGRRGRRRLHPR----------------------------PAVKKAQ LEDAFVEVSLSESSAPLGPGR-------------------------------R--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------VRKTKPCAHRELRKK SDLIGSPKSTHPKRLGKR-------------------------------------------------------------- ---------------------------------------------------------PLDDTEVDKVEQPRKRARLNSST PQRKTRKSKLLAETTERAVESAPAPRTSR-----------------------------------------WGSKPLEQRQ PAKKRKRASAGRPSLSPASK-RPSPAAAHTES---SGEERPVSPCESTDDAPPGTSASVKRAERG-SAAKKDNVCQVCEL PGE-ALLLCEGQCCGAFHPRCVGLKEKPPGKFLCQECTTGVRPCFSCKQAA------GELKRCAVPQCGRFYHEACVRQS ALTVFENKG-FRCPLHVCLSCHVS------HPSRLKAKKGKMLRCVRCPVAYHAGDQCIAAGCELLTSSSIICTNHFTA- KKGYSHHTHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-GMPDG---SWYCNDCKA---------------GKKPKYRDIIWVKLGSYR-WWPAEIRHPRGIPT NIQHLRHELGEFPVFFFGSKDYFWTHQARVFPYMEGDRGS-KYQ-R-NGIGKVFKNALLEAEMRFKEIKMEREAKEAQEN DR---KPPPYKYIKVNKPCGKVQIRTADISEIPKCNCKPVDEKPCGFESECLNRMLMYECHPAVCPAGASCQNQGFTKRQ YPETKIIKTA-GKGWGLVAKRDIKK------------------GEFVNEYVGELIDEEECRARIKYAQENDITHFYMLTI DKDRVIDAGLKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGAPNCSG FLGDRPKN------APSGASEDKGKKAKKKLRRRRARHEG-KKSEDECFRCGDGGQLVLCDKKGCTKAYHLSCLDLTKRP FG-----------RWDCPWHHCDV--CGKNSVAFCQLCPNSFCKAHQEGALRPWGTSGQLCCQEHEDQELHPSLDRKEAE A----ERPPADRQRPAKNSKKA---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Latimeria_chalumnae_NSD2 -------------------------------------------------------------------MDLSAKGSSLLLK QELLNPISMKPAAGILGSANGKTQNGEMNPDPAVLIDK-----VAATLHEGVITKLNSHDALPFLQADKLKNLTSRVLNG DSETQESKLAADAQ-------EVMGTRTP--------------------------------------------------- ------------------------------------------------PHNTPKK---SGSPEIKLKITKTYMNGKPLFE SSICGDGEAG-----ETELPVEKDLITESKEKRVRKKSLKYDALLEQSLAEAALEVKTSNASQK---------------- ----------------------------------------EEKVKSIS-------------------CEN---------- -DGEDQTPKYGIGAIVWSKVSGYPWWPCMVSADPLLNSHFRIK--GQNRTF------RQYHVQFFGDAPERAWICEKGIV PYEGQEQFEQLCQESIKQA-AKTEKNKLRKTVPAKWRAQWDIGLTQAEEAKEMTVEDRK--------------------- ---------------------AKYTFVYVKDHPRLNPQVAMKMGIPVEP---LEDFSETSES------------------ ------LASATCQEKGKRDSR--ASREKRRASKPSASSRRRSTSS-------------ER-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------TDSESPVVSPVSKKRG GVSTPRSKKGDAAMTQFLVFCQKHRDEVVAEHPDASGEEIEELLES-------------------------QWNMLSEKQ RARYNTKFSIVTP-RVEPNSP------------------------------ER--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NSAKGKQRKRPLEVT EDTATQEAPKKRLRHDSQ-------------------------------------------------------------- --------------------------------------------------------------NQNK-GKHSKPKSSADSG A------KATETVASLNKQSAISKLA------------------------------------------------DACKPL KKRNRSSAAESPAP--SKSSSPSNTLTENETPSEGHGDERSDSPYESADETQTEVSVSSKKSERGAAAAKREFVCQICET TGE--LLHCEGQCFGVFHLNCLGLSEKPRGKFVCRECTSGVHTCFACKKND------ADVKRCIAPQCGKFYHEECVKKY QSTMFESKG-FRCPFHTCVSCQAA------YPTNPRATKGKMVRCIRCPVAYHGGDLCIAAGCAILTANSIICTNHFRA- NKGKSHHSHINVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWYCNDCRA---------------GKKPRYQDIVWVKLGNYR-WWPAEVCHPKNVPA NIQKMKHDIGEFPVFFFGSKDYYWTHQARIFPYMEGDRGS-KHQ-T-KGIGKVFKNALKEAEARFLEVKLQRETKEAQEN ER---KPPPYKYIKVNKPCGKVQIHTADISEIPKCNCKPTDENPCGLDSECLNRMLMYECHPAVCPAGERCQNQCFTKRQ YPETKIIKTE-GKGWGLISKRDIKK------------------GEFVNEYVGELIDEEECRARIKHAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPKE-TELTFNYNLDCLGNE-KTVCRCGAPNCSG FLGDRPKN------ASTNNADDKGKKAKKKPKKRKSKSEGKKEYEDECFRCGDGGELVLCDRKSCTKAYHLSCLDLTKRP FG-----------KWECPWHHCDV--CGKPSVTFCHFCPNSFCKEHQEGVLFRSAVEGQMCCSEHDLDVDNTREPQTTLQ ETSNLLPKKSRANNR--------AQTDHT--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Myotis_lucifugus_NSD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------ESPDESADETQTEVSVSSKKSERG-LTARKEHVCQLCEK PGR--LLLCEGACCGAFHLSCLGLPRPPEGGFVCSECVSGIHSCFVCKEST------ADAKRCSVPQCGKFYHEACVRRF PLTVFEGRG-FRCPLHGCVSCHAS------HPSSSRATKGKMMRCLRCPVAYHGGDACLAAGCLVVSSHSIVCTAHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLSI-DMPDG---SWFCNDCRA---------------GKRLHHQDIVWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-SGIGRVFKNALQEAEARFREIKLQREARETQES ER---KPPPYKHIKVSARAG-GGVWGAPSPAAPRCTCLP--ACPASLSGALLHEHEG--CGQPVCQLSRRRDSYCHRTRP P-------AP-G-GLQPVLR---PQ------------------GEFVNEYVGELIDDEECRARIKHAQENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAMCDIPAG-TELTFNYNLDCLGNE-KTVCRCGAPNCSG FLGDRPKT------STVLSSEEKGKKTKKKSRRRRTKGEGKKESEDECFRCGDGGQLVLCDRKSCTKAYHLSCLGLGKRP FG-----------KWVCPWHHCDV--CGKPSASFCHLCPNSFCKEHQDGTTWRSTADGRSYCCEHDSGAEAQS------P FPAPRRPQGRRRR------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Canis_lupus_familiaris_NSD2 -------------------------------------------------------------------------------- --------MKQAPEILGNTNGKTQNCEVNRECSVFLSKA---HLSTSLQEGVMQKFNGHDALPFIPSEKLKDLTSRVFNG EPGAHDAKLRFESQ-------EGKGLGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDGAA------AVSQSEENGQKAENKARRSRKRSIKYDSFLEQGLVEAALVSKISSPSDK---------------- ----------------------------------------KIAAKKES-------------------CPN---------T GRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSIEERK--------------------- ---------------------AKFTFLYVGDQLHLNPHVAKEASIAVES---PAQVVESSGV------------------ ------IEEAADNPKSLREEG--IPIKRRRRAKLSGSAENQESEP--GTVKSTPQKVAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADPKRGVGCPPGRKKS VASTPRSRKGDAAS-RFLVFCQKHRDEVVAEHPDASGEEIEELLGS-------------------------QWDMLNEKQ KARYNTKFALVASSQSEEDSG------------------------------NI--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRIHTKRTQEPT EDADGEDAPRKRLRTDKH-------------------------------------------------------------- --------------------------------------------------------------GLRK-RETINDKTARTSS C------KAIEAASSLKSQAATKHLS------------------------------------------------DACKPL KKRNRASTAAS-STPFSKSSSPSASLTENEVS-DGPGDEPLESPYESADETQTEVSISSKKSERG-VTAKKEYVCQLCEK TGS--LVLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESK------TDVKRCVVSQCGKFYHEACVRKY PLAVFESRG-FRCPLHSCVSCHAS------NPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-DMPDG---SWFCNDCRA---------------GKRLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQNLKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQEN ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------SASLSSDEKGKKTKKRTRRRRTRGEGKKESEDECFRCGDGGQLVLCDRKSCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTSFCHFCPNSFCKEHQDGTAFSSTQDGRSYCYEHDLGAESARSTKTEKP FPEPMKSKGKRKKRR-----CWRRVTEGK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Felis_catus_NSD2 -------------------------------------------------------------------------------- --------MKQAPETLGSTNGKTQNCEVNRECSVFLSKA---QLSTSLQEGVMQKFNGHDALPFIPSEKLKDLTSRVFNG EPGAHDARLRFESQ-------EVKALGTP--------------------------------------------------- ------------------------------------------------PSTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDGAA------AVSQSEEHGQKPENKARRNRKRSIKYDSLLEHGLVEAALVSRISSPSDK---------------- ----------------------------------------KVAAKKES-------------------CPN---------T GRDKDHLLKYSVGDLVWSKVSGYPWWPCMVSADPLLHNYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWETGIVQAEEAASMSVEERK--------------------- ---------------------AKFTFLYVGERLHLNPHVAKEAGVSVEAP-PLGPMVEPSGV------------------ ------PEEAAADPKSMREEG--VPIKRRRRGKLSSSAENRAGDP--GTVQSTPQKMAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADPKRGVGSPPGRKKA TASAPRSRKGDAAS-QFLVFCQKHRDEVVAEHPDASAEEVKELLGS-------------------------QWDMLNEKQ KARYNTKFALVASPQSEEDSG------------------------------NV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRNHTKRTQDPP EDVEIEDAPRKRLRTDKH-------------------------------------------------------------- --------------------------------------------------------------GLRK-RETASDKTARTGS C------KAMEAATSLKSQAATKHLS------------------------------------------------DACKPL KKRNRASAAASCAP-FSKSSSPSASLTENEVS-DGPGDEPAESPYESADETQTEASVSSKKSERG-VAAKKEYVCQLCEK PGS--LLLCEGPCCGAFHLACLGLARRPEGRFTCSECASGIHSCFVCKESK------TDVRRCVVSQCGKFYHEACVRKY PLTVFESRG-FRCPLHSCVTCHAS------NPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASHSIICTSHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLSI-EMPDG---SWFCNECRA---------------GKKLHFQDVVWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQES ER---KPPPYKHIKVNKPYGKVQIHTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------STSLSSEEKGKKSKKRTRRRRTRGEGKKESEDECFRCGDGGQLVLCDRKSCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGRPSTSFCHFCPNSFCKEHQDGAALGSTRDGRPCCCEHDLGAVSARSAQTGKP FPEPSKSKGKRKRRSEEPAPGVVIVTVL---------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Bos_taurus_NSD2 -------------------------------------------------------------------MEFSVRK-SPLSA PKVVKCVKMKQAPEVLGSANGKTPSCDVSRECSVFLSKA---QLSAGLQDGVVQKFNGHDALPFIPAERLKDLTSRVFNG EPGAHDAKLRFESQ-------EVKGLGTP--------------------------------------------------- ------------------------------------------------PHTTPVK---NGSPEIKLKITKTYMNGKPLFE SSICGDGAA------AVSHSEADGQRPEYKARRSRKRSAQRGPVLEHGLGEAALASRLSSPVDK---------------- ----------------------------------------KIPVKRES-------------------CPN---------S SRDKGQLLKYDVGDLVWSKVSGYPWWPCMVSADPLLHSHTRLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGLVQAEAAARMAVEERK--------------------- ---------------------AKFTFLYVGDQLRLNPHVAKEAGVAVES---LGEAAEPSGV------------------ ------EEEAADSPKSSGEEG--APVKRRRRAKLSSSTENLPGDP--GPGRATPQKVAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADSRRGAGSPPGRKKA AASTPRSRRGDAAS-QFLVFCQKHRDEVVAEHPDASAEEIEELLAS-------------------------QWNMLNEKQ KARYHTKFALVAPPQSEEDSG------------------------------NL--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRSHTKRTQGLR GDAEVEEAPRKRLRTDRH-------------------------------------------------------------- --------------------------------------------------------------GLRK-RETITDKTARTTS C------KALEAASSLKSQAATKHLS------------------------------------------------DACKPL KKRHRAPAAAATTLTFSKSSSPSASLTENEVS-DGPGDEPPESPDESADETQTEASVSSKRSERG-ATARKEHVCQLCEE PGS--LVLCEGPCCGAFHLACLGLSRRPEGRLLCGECTSGIHSCFVCKESK------SDVKRCVVSQCGKFYHEACVRRF PLTVFESRG-FRCPLHSCLSCHAS------NPSNPRPSKGKMLRCVRCPVAYHGGDACLAAGCSVIASNSIICTNHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLSI-EMPDG---SWFCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEVGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQES ER---RPPPYKHIKVNKPYGKVQVHTADISEIPKCNCKPTDENPCGSDSQCLNRMLMFECHPQVCPAGESCQNQCFTKRQ YPETKIVRTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKRAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------SAPLSSEEKGKKTKKKARRRRTKGEGKKPSEDECFRCGDGGQLVLCDRKSCTKAYHLPCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTAFCHFCPNSFCKDHQDTAAFSSTQDGRLYCSEHDFRAEPARSAQTEQP CPGPSKAKGRRRRRR-----CWRRVMEGE--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Pan_troglodytes_NSD2 -------------------------------------------------------------------MEFSIKQ-SPLSV QSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKA---QLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNG EPGAHDAKLRFESQ-------EMKGIGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDSAA------DVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDK---------------- ----------------------------------------KIPAKKES-------------------CPN---------T GRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERK--------------------- ---------------------AKFTFLYVGDQLHLNPQVAKEAGIAAES---LGEMAESSGV------------------ ------GEEAAENPKSVREEC--IPMKRRRRAKLCSSAETLESHP--DIGKSTPQKTAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADPRRGVGSPPGRKKT TVSMPRSRKGDAAS-QFLVFCQKHRDEVVAEHPDASGEEIEELLRS-------------------------QWSLLSEKQ RARYNTKFALVAPVQAEEDSG------------------------------NV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRNHTKRIQDPT EDAEAEDTPRKRLRTDKH-------------------------------------------------------------- --------------------------------------------------------------SLRK-RDTITDKTARTSS Y------KAMEAASSLKSQAATKNLS------------------------------------------------DACKPL KKRNRASTAASSALGFSKSSSPSASLTENEVS-DSPGDEPSESPYESADETQTEVSVSSKKSERG-VTAKKEYVCQLCEK PGS--LLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESK------TDVKRCVVTQCGKFYHEACVKKY PLTVFESRG-FRCPLHSCVSCHAS------NPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWFCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQES ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------STTLSSEEKGKKTKKKMRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKP PPEPGKPKGKRRRRR-----GWRRVTEGK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gorilla_gorilla_NSD2 -------------------------------------------------------------------MEFSIKQ-SPLSV QSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKA---QLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNG EPGAHDAKLRFESQ-------EMKGIGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDSAA------DVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDK---------------- ----------------------------------------KIPAKKES-------------------CPN---------T GRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERK--------------------- ---------------------AKFTFLYVGDQLHLNPQVAKEAGIAAES---LGEMAESSGV------------------ ------SEEAAENPKSVREEC--IPMKRRRRAKLCSSAETLESHP--DIGKSTPQKTAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADPRRGVGSPPGRKKT TVSVPRSRKGDAAS-QFLVFCQKHRDEVVAEHPDASGEEIEELLRS-------------------------QWSLLSEKQ RARYNTKFALVAPVQAEEDSG------------------------------NV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRNHTKRIQDPT EDAEAEDTPRKRLRTDKH-------------------------------------------------------------- --------------------------------------------------------------SLRK-RDTITDKTARTSS Y------KAMEAASSLKSQAATKNLS------------------------------------------------DACKPL KKRNRASTAASSALGFSKSSSPSASLTENEVS-DSLGDEPSESPYESADETQTEVSVSSKKSERG-VTAKKEYVCQLCEK PGS--LLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESK------TDVKRCVVTQCGKFYHEACVKKY PLTVFESRG-FRCPLHSCVSCHAS------NPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWFCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQES ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------STTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKP PPEPGKPKGKRRRRR-----GWRRVTEGK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Macaca_mulatta_NSD2 -------------------------------------------------------------------MEFSIKQ-SPLSV QSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKA---QLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNG EPGAHDAKLRFESQ-------EMKGIGTP--------------------------------------------------- ------------------------------------------------PNTTPIK---NGSPEIKLKITKTYMNGKPLFE SSICGDSAA------DVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDK---------------- ----------------------------------------KIPAKKES-------------------CPN---------T GRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERK--------------------- ---------------------AKFTFLYVGDQLHLNPQVAKEAGIAAES---FGEMAESSGV------------------ ------GEEAAENPKSAREEG--VPMKRRRRAKLCSSAETLESDP--DVVKSTPQKTAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADPRRGVASPPGRKKT TASTPRSRKGDAAS-QFLVFCQKHRDEVVAEHPDASGEEIEELLRS-------------------------QWSLLSEKQ RARYNTKFALVAPVQAEEDSG------------------------------NV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRNHTKRTQDPT EDVEVEDTPRKRLRTDKH-------------------------------------------------------------- --------------------------------------------------------------SLRK-RDTITDKTARTSS Y------KAMEAASSLKSQAATKNLS------------------------------------------------DACKPL KKRNRASTAASSALGFSKSSSPSASLTENEVS-DSLGDEPSESPYESADETQTEVSVSSKKSERG-VTAKKEYVCQLCEK PGS--LLLCEGPCCGAFHLACLGLSRRPEGRFTCSEW---IHSCFVCKESK------TDVKRCVVTQCGKFYHEACVKKY PLTVFESRG-FRCPLHSCVSCHAS------NPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWFCNDCRA---------------GKKLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQES ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TELTFNYNLDCLGNE-KTVCRCGASNCSG FLGDRPKT------STTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRP FG-----------KWECPWHHCDV--CGKPSTSFCHFCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSAKTEKP PPEPGKPKGKRRRRR-----GWRRVTEGK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Otolemur_garnettii_NSD2 -------------------------------------------------------------------MEFSIKK-NPLSV QKVVKCIKMKQAPEILGNTNGKTQSCEVNRECSVFLSKA---QLSNSLQEGVMQKFNGRDALPFIPAEKLKDLTSRVFNG EPGTHDAKLRFEPQ-------EMKGMGTP--------------------------------------------------- ------------------------------------------------PSTTPVK---NGSPEIKLKITKTYMNGKPLFE SSICGDSAA------DMSQSGENGQKSENKARRNRKRSVKYDSLLEQGLVEAALVSKISSPSDK---------------- ----------------------------------------KIPLKKDS-------------------CPS---------I GRDKDCLLKYNIGDLVWSKVSGYPWWPCMVSADPLLHSYTKLK--GQKKSA------RQYHVQFFGDAPERAWIFEKSLV AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERK--------------------- ---------------------AKFTFVYVGDQLHLNPQVAKEAGIAVEF---SGEMAGASEV------------------ ------SEETAENPKFVREEA--IPVKRRRRTKLSGSAENQESDP--GTGRNSPQKMAE--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------ADPKRGVGSPPGRKKT TASTPRSRKGDAAS-QFLVFCQKHRDEVVAEHPDASGEEIEELLGS-------------------------QWNMLNEKQ KARYNTKFAPVTSAPSEEDSG------------------------------NL--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------NGKKRNHTKRTQNPT DDIEVEDAPRKRLRTDKH-------------------------------------------------------------- --------------------------------------------------------------SLRK-RDTITDKTTRTSS Y------KVTEAASSLKSQAATKNLS------------------------------------------------DACKPL KKRNRASATASSALGFSKSSSPSASLTENEVS-DSPGDEPSESPYESADETQTEVSISSKKSERG-MTAKKEYVCQLCEK TGS--LLLCEGPCCGAFHLSCLGLSRRPEGRFTCSECTSGIHSCFVCKESK------TDVKRCVVTQCGKFYHETCVRKF PLTVFESRG-FRCPLHSCVSCHAS------NPANPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIVCTAHFTA- RKGKRHHAHVNVSWCFVCSK-----------------------------------------------------GGSLLCC ESCPAAFHPDCLNI-EMPDG---SWFCNDCRA---------------GKRLHFQDIIWVKLGNYR-WWPAEVCHPKNVPP NIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGS-RYQGV-RGIGRVFKNALQEAEARFREIKLQREARETQEN ER---KPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQ YPETKIIKTD-GKGWGLVAKRDIRK------------------GEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTI DKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG-TAL-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Homo_Sapien_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIAEDGGQTPYEATL--QQGFQYP-ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNG SANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQP------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVDTVSEKPREEPVLKEEAPVQPILSSVPTTE---------- ---VSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNT------------------ ------------QPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTPNQRNEKPT QS---VSSPEATSGSTGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQATVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICES SGD-SLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGK------DVKRCSVGACGKFYHEACVRKF PTAIFESKG-FRCPQHCCSACSMEK-------DIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHS--- KRSSNSS-AVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC ESCPASFHPECLSI-EMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKSA-----CASTNEEKAKNAKLKQKRRKIKTE-PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCDE--CSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVS-------- -PEYWSKIKCKWESQDHGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Mus_musculus_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNHSDIVEDGGPTPFEATL--QQGFQYP-PTTEDLPPLTNGYPPSISLYETQTKYPPYNQYPNG SANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPLP-------------------------------------- --------------------------------------PPPPPPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNRHESSRSEERRSHKIPKLEPEGQNRPNE--------------- --------------------------------------RVDTAPEKPREEPVLKEAIPVQPILSSVPTTE---------- ---TSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHSKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERV--------------------- ---------------------EQYTFIYIDKQPEEASSQAKKNVTSKTEVKKPRRPRSVLNS------------------ ------------QPEQTNAGEVASSQSSTDLRRQSQRRHTSLEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISSPSQRSEKPA QS---ASSPEATSGSAGPV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS AEV-VPKKKIKKEQVETAPQASLKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVETA-SCTYRDTSDSDSRGLSDGQVGFGKQVDSPSATADADASDAQSVDSSLSRRGVGTSKKDTVCQVCEK AGD-CLVACEGECCRHFHVECLGLTAVPEGHFTCEECETGQHPCFSCKVSGK------DVKRCSVSVCGKFYHEACVRKF PTAIFESKG-FRCPQHCCSSCSMEK-------DIHKASKGRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHS--- KR-SSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNR-AELMKLPMIP-SSSASKKRCEK--GGRLLCC ESCPASFHPECLSI-DMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICSPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-HFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEM ERTSRKPPPYKHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRL YPDAEVIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTVCHCGADNCSG FLGVRPKSA-----CTSAVDEKTKNAKLK-KRRKVKAE-AKPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP HG-----------KWECPWHRCDE--CGSVAVSFCEFCPHSFCKAHGKGALVPSALEGRLCCSSHDPASPVS-------- -PEYWSKIRCKWESQDSGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Callithrix_jacchus_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIAEDGGQTPYEATL--QQGFQYP-STTEDLPPLTNGYPSSISMYEPQTKYQSYNQYPNG SANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQP------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVDSVAEKPREDPVLKEEAPVQPILSSVPTTE---------- ---VSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYIDKQPEEALSQAKKNVASKTEVKKTRRPRSVLNT------------------ ------------QPEQTNAGEVASSLSSTEIRRHSQRRHTSVEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTPNQRNEKPT QS---VSSPEATSGSTGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQATVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADISDVQSMDSSLSRRGTGMSKKDTVCQICES SGD-SLIACEGECCRHFHLECLGLTSLPDSRFICMECKTGQHPCFSCKVSGK------DVKRCSVGACGKFYHEACVRKF PTAIFESKG-FRCPQHCCSTCSMEK-------DIHKASKGRMMRCLRCPVAYHTGDACIAAGSMLVSSYILICSNHS--- KRSSNSSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC ESCPASFHPECLSI-EMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKSA-----CASTTEEKAKNAKLKQKRRKIKTE-PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCDE--CSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMSPVS-------- -PEYWSKIKCKWESQDHGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Rattus_norvegicus_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIVEDGGPTPFEATL--QQGFQCP-PATEDLPPLTNGYPPSISLYETQTKYPPYSQYPNG SANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPP----------------------------------------- --------------------------------------PPPLLPPPPPPVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHL-----KSKHESRKEKRKKSSRHESSRSEERKSHKVPKLEPEGQNRPNE--------------- --------------------------------------RVDPAPEKPREEPVLKEAVPVQPILSSVPTTE---------- ---TSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALQMTREERV--------------------- ---------------------EQYTFIYIDKQPEESPSQAKKSVTSKAEVKKPRRPRSVGNS------------------ ------------QPEQTSAGEVASPQSSTDPRRQSQRRHTSVEEDG---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WRTAAARKSLPASIT---MHKGSLDLHKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISSPSQRNEKST PS---ASPPEATSGSAGPV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VSKKKIKKEQVETSPQASLKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVETA-SCTYRDTSDSDSRGPSDGQVGFGKQVDSPSAAADADASDAQSVDSSLSRRGVGLSKKDTVCQVCEN TGD-SLVACEGECCRHFHPECLGLAAVPEGRFTCEECETGQHPCFSCKVSGK------DVKRCSVSVCGKFYHEACVRKF PTAIFESKG-FRCPQHCCSSCSMEK-------DIHKASKGRMMKCLRCPIAYHFGDACVAAGSVSVSSHILICSNHS--- KR-SSHSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNR-AELMKLPMIP-SSSASKKRCEK--GGRLLCC ESCPASFHPECLSI-DMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAETCSPRSVPL NIQGLKHGVGDFPVLFFGSHDYYWVHQGRVFPYVEGDT-NFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKTSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPGDENPCGLESECLNRMSQYECHPQVCPAGDRCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTVCHCGADNCSG FLGVRPKSA-----CTSAADEKTKNAKLK-KRRRGKAE-AKQIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCDE--CGSAAISFCEFCPHSFCKAHEKGALVPSALEGRLCCSNHDPASPVS-------- -PEYWSKMRCKWESQDGGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Equus_caballus_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIVEDGGQTPYEATL--QQGFQYP-PTTEDLPPLTNGYPPSISMYETQTKYQSYNQYPNG SANGFGAVRNFSPADYYHSDIPNTRPHEILEKPSPPQP------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVDTVSEKPREDLVLKEETPVQPILSSVPTTE---------- ---VSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYIDKQPEEALSQAKKNVASKAEVKKTRRPRSVLNT------------------ ------------QPEQTNAGEVASSLSSTEIRRHSQRRHMSVEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTPNQRNEKAT QN---ISSPETTSGSTGSA------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQATVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATAEADVSDVQSVDSSLSRRGIGMSKKDAVCQVCES SGD-SLIPCEGECCKHFHLECLGLASLPDGKFVCMECKTGQHPCFSCKMSGT------DVKRCSVGACGKFYHEACVRKF PTAIFESKG-FRCPQHCCSACSMEK-------DVHKASKGRMMRCLRCPVAYHTGDACIAAGSMSVSSCIFICSNHS--- KRSSNSSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC ESCPASFHPECLSI-EMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKSSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKSA-----CASTTEEKAKNAKLKQKRRKIKTE-PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCNE--CSSAAVSFCEFCPRSFCKDHEKGLLVPSALEGRLCCSEHDPVSPVS-------- -SEYWSKIKCKLESQDPGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Monodelphis_domestica_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNSSDIVEDG-QTPYETSL--QQGFQYP-PTTEELPPITNGYPPSISMYEPQAKYQTYSQYPNG SANGFGAVRNFSPTDYYHTEISNTRPHEVLEKPSPQQP------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEYA-----KSKHEGRKEKRKKSNKHDSSKSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVNVLSEKPREDSMVLEETPVQQYLPSLP-AE---------- ---VSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEQLLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYVDKQPEEVLSQAKKSAASKTEVKKNRRPKAVLNT------------------ ------------QPEQSNAGEAASSLPSTEIRRHSQRRHTSVEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------AAGDGKF IDQFVYSTKGVGNKTEISVRGQDKLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTTNQRNEKAT QN---VSSPETTSGSTGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQTTVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLNDLQVSFGKQLDSPSAAADADASDVQSVDSSLSRRGTGTSKKDTVCQICES YSD-SLVVCEGECCKHFHPDCLGLSSLPDGRFLCTECKTGHRTCFSCKIPGK------DVKRCSVPACGKFYHEACVRKF ATAVFESRG-FRCPQHCCSTCSMEK-------DIHKASKGRMMRCLRCPIAYHSGDGCIAAGSRCVSSYLLICSNHS--- KRSNHSSSTINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELK-LPMIP-SSSASKKKCEK--GGKLLCC ESCPASFHPECLNI-EMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFHELKAQRENKEALEL ERNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRL YPDAEVIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSITNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDIRVGLFALCDIPAG-VELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKTA-----FASANEEKAKNAKLKQKKRKIKTE-QKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCDT--CSNSAVSFCEFCPRSFCKDHEKGALVPSTLEGRLCCSKHNPKSPVA-------- -PEYWNKIRCKLEPQDPGDEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gallus_gallus_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDASSDIAEDGGQTPYEAAL--QQGFQYPTPTAEDLPPIANGYPATINMYEPQAKFQTYSQYPNG SANGFGTVRNFSPPEYYHMENSNARPHEVLEKPSPPQP------------------------------------------ -------------------------------------------PPPPPPVSQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEYA-----KAKHEGRKEKRKKSSKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RLSMLSERPRED-ALLEEAPVQQFLPSLP-TQ---------- ---VSHDIKFQVGDLVWSKVGTYPWWPCMVSCDPQLDVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEQLLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYIDKEPEEVLSKAKKTTASKSETKKNRRPKPALNT------------------ ------------QTEHANVVT--GSPSSAELRRQSQRRQSSAEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHN--LDLQKCNMSPVVKIEQVFALQN----------------------------AAGDGKL IDQFVYSTKGVGNKAEISVKGQEKLN------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------SSS-SQRNEKAT CNVQNASSPETTSGSAGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVEMVPLTAVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVELT-SSAYRDASDSDSRGLNDLQGSFGKRSDSPSAAVDADASDVQSVDSSLSRRGTGTNKKDTVCQICES SGE-SLVSCEGECCSTFHMECLGLKAMPEEKFFCTECKNGEHTCFSCKLPGK------DVKRCSVSACGKFYHEACVRKF ATALFESRG-FRCPQHCCSACSVDK-------DIHKASKGRMVRCFRCPIAYHSGDGCIAAGSLFVSSHILICSNHS--- KR-NHSSSAVNVGFCFVCARGLVVQDHSDPLFSSYAYKSHYLLNESNR-AELMKLPMIPPPSSASKKKCEK--GGKLLCC ESCPASFHPECLNI-DMPEG---CWNCNDCKA---------------GKKLRYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI ERNSRKPPPYKHIKSNKVIGKVQIQVADLSEIPRCNCKPSDENPCGLESECLNRMLQYECHPQVCPAGERCQNQCFTKRL YPDAEIIKTD-RRGWGLRTKRNIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDIRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGAENCSG FLGVRPKTA-----FATANEEKVKNAKLKQKKRKIKTE-QKQMHEDNCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP FG-----------KWECPWHQCDI--CSSPAVSFCEFCPHSFCKDHEKGALLASALDGRLCCSTHDPKSPVA-------- -PEYWNKIKCKLEPQNPVEEAKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Anolis_carolinensis_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANNRQE-DAFDASSDITEDGRQTPYEAALSLQQGFQYPTPTTEDLPPLINGFPP-ISMYEPQAKYQSYSQYPNG SANGFGSVRNFSPPEYYQMENSNLRPHEILEKQSPPQP------------------------------------------ -------------------------------------------PPP--SVSQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEYA-----KPKHEGRKEKRKKSNKHDASHSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RISNQSERPREEPIVLDETPVQEASPSPP-TP---------- ---VVSDVTFEVGDLVWSKVGTYPWWPCMVSRDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGRKQYDQLVAEATKQAN-HSEKQKIRKPRPQRERAQWDIGIAHAEKALKMSREERI--------------------- ---------------------EQYTFIYVDKEPEEALTKTRRTVVPKMEARKNRRSKPSPSP------------------ ------------QPEPASEASPASSPSNTEVRRHSQRRQSSVEEE----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHQGTLDLQKCNMSPVVKIEQVFALQN----------------------------AAGNGKF IDQFVYSTKGLGSKPEIIIKGHDKLT------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------SVS-SQRNERAS S--QRSPSPETSSGLASSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETAPQTALKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVELT-SSAYRDTSDSDSRGLNDLQGSFGKQSDSPSAAADADASDVQSVDSSLSRRGSGTSKKDSICQICES SGE-SLLSCEGECYRVFHTECLGLSSQPEGKFICIECKNGQHTCFSCKLPGK------DVKRCSVNACGKFYHEACVRKF ATTVFESRG-FRCPQHCCTSCSVDK-------DIHKASKGRMVRCLRCPIAYHSGDGCIAAGSLFVSSHILICSNHS--- KRSNHSSSAVNVGFCFVCARGLIVQDHSDPLFSSYANKSHYLLNESNR-AELMKLPMIPPSSSASKKKCEK--GGKLLCC ESCPASFHPECLHI-EMPNG---SWNCNDCKA---------------GKKLRYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--NINKTFKKALEEAAKRFQELKAQRESKEALEI ERNSRKPPPYKHIKSNKVVGKVQIQVADLSEIPRCNCKPSDENPCGLESECLNRMLQYECHPQVCPAGEGCQNQCFTKRL YPEAEIIKTD-RRGWGLRTKRNIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCHPNCETQKWTVNGDVRVGLFAVCDIPAG-MELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKTA-----CATANEEKAKNAKLKQKKRKIKTE-QKQMHEDNCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP FG-----------KWECPWHQCEI--CGNPATSFCEFCPHAYCKEHEKGALVASALEGRPCCSEHNPKAPVA-------- -PEYWCKIKRRLEQQNPEEEAKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Danio_rerio_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DVYEAISDPGDDGGQQNFDSPL--ESGFSYP---AEDVPVITNGYPTGVGTYEQQAKFALYSQFPNG SANGYGAIRNYGDHSLLLGEGTVLRPPVVQEKPQTHISPPSHSHHHQQPHHPHHHHHQQQQQHHP--------HNPPLLP HHHHHHPPPASHLMPQVLPPPPPLLLPSSPPLLSPQESTISNPIGQPVNTIITTTPKKTSSPEIKLKIIKTYQNGRELFE SSLCGDLLQEFQAGEDS-----RRQHEQKKEKRKKRGSRHGAGHEESQ---QPSKVEEERSVVVH--------------- --------------------------------------NPVQTTESQVAFREEQQPQSSLKSPKAELKEQKVEK-HCPSV ITSTGTSQEYEIGDLVWAKVGTYPWWPCMVSSDPQSNVHTRIN-TRGC---------KEYHVQFFGSVPERAWIHEKRTV VYKSENQFDELQAETLRKSTNPTEKQKLLKPQSQKERAQWEVGVGHAEAALQMTREERN--------------------- ---------------------ENYTFIYIDKEPGADAET-AAAPAPAPD-SAPTAPTDTVTSPKATAKNRPERKQRRSRG SAGAKEEPIPRRQQPRRQCSMNSVGETSSPNQGEDAMEQEQPCSPPKP-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------APRPKEPSPPPVRTP WRTAAARKLLPLSIT---MKKLNVEIIKCDWQLPKQKVELPKKTESEE-----------------RPSSRVKSPEGSSNK AEAETCSSEEERAASPSGWSDQEHTSAEQSTG------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------IHWISASTERKQ RC----TDVVLRCKSDQGN------------------------------------------------------------- ------------------------------------------------------VLCVCAKTERKQQRRSVRSRSESEKS VEP-VPKKKVKKEQAETAPQMDFKTG---------------------------------------SQKGASEISDSCKPL KKRSRASTDVEMA-SSLYRDTSDSDSRGLNDPQTGFGKRSDSPAT-VDADGSDAQSVDSSLSRQGGSSSKKDTVCHVCET FGD-SLVSCEGDCNRLFHPECMGSNSGKESETVCQECKTGSHPCFSCKVTEG------DMKRCSVNGCGRYYHETCVRKY TGSASDTKG-LRCPQHSCATCCLDR-------DLQKAGKGRMMRCIRCPVAYHTGDGCVAAGSVLITPHIIICSNHSSS- RKNGHFSSPVNVGWCFICAR-----------------------------------------------------GGRLLCC EACPASFHPECLKI-EMPEG---TWLCGECKS---------------GKKPHYKQIVWVKLGNYR-WWPAEICNPRLVPS NIQSLKHDIGDFPVFFFGSHDYYWINQGRVFPYVESDK-NFAEGQV--GINKTFKKALEEAAKRFQELKAQRETKEALEQ ERNSRRPPPYKLIKSNKPFGKVQLHVADLSEIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRL YPDTEVIKTT-GRGWGLKTKQDLKK------------------GDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTL TKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISAD-TELTFNYNLDCLGNG-RTSCHCGSENCSG FLGVKPKSA-----VVMEREEKVRNAKLKPKKRKLKTE-SKQTHELYCYCCGEGGELVMCDKKDCPKAYHLLCLNLSKPP YG-----------RWECPWHQCSV--CQRTATSFCHFCPASFCREHERGQLAVSALDKQPCCSNHDPKRPLG-------- PQANRSQVTVKKEPLDGNANEEEEEEEEETGDGE---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Takifugu_rubripes_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-GTCDTGSDPGEDGGP-SYDAAL--DSEFSYPPSASEDMSQVSNGYPPGLGLYEPQAKFSMYSQFPNG SANGYGAIRSYGEHGLLPGEGTVLRGPGLQERPLSPVSPPLSTHHPHLHHHHHHHAHHYHSNQP---HIQTHPHTQSPPP PPSQHHLSQTPHIMTHTLPHPPPLHLPSSSPPPSLVDSTPSSQPSHAPSNTSGGVLKKTSSPEIKLKIIKTYQNGKELFE SALCGDLLEELQESQKKEASQTQRRHERKKEKRKKSARLQLQVQEQS----LNQSQTQAGTLTLP--------------- --------------------------------------DDTNMHPQLVEMP--QTEKPQKTTVKTVPKTPKVPKVHHQSV IQETGFCKEFVIGDLVWSKVGTYPWWPCMVSSDPQMKVHTRIN-TRGH---------REYHVQFFGSVAERAWIHEKRIV IYQGKQQFEDLQAETLRKATNPVEKQKLMKPIPQRERSQWEVGVGHAEDAFVMTRQERI--------------------- ---------------------DNYTFIYVDPDPNEAPP--SKKPNIRAE-KQNRRSSGSVRKEEGGV---------KSPD REQPPRRQLPRRQCSVSNTDDSTNSQASNDDHRESQHSATSPKQSVGC-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------DVQDQQDSPPPVR-A WKTAAARKLLPLSIT---MKRLNVEITKCDWPLLQKKAALSPKN---------------------DSDEKEERVEREARQ PDLGYCSPEECRAKPEPSLEEDEDGDEGEEESD----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------DRRGSPASQKSEEGDMQQ MY----SPGSHHSSPQGSQ------------------------------------------------------------- --------------------------------------------------------------ERKLQRRSVRSRSESERG SDP-VPKKKTKKEQAEIAPETTLRTG---------------------------------------SQKGASEISDACKPL KKRSRASTDVEMA-SSQYRDTSDSDSRGLSDPQGLFGKNLDSPAA-ADG--SDTQSVDSGLSRQDSNTDKRDTVCQICEA YGE-SLVVCEGDCNRQFHLECLGLTAQPEGRFICLECRNGDHPCFSCKTAGQ------EVTRCSVSGCGCYYHEDCVRKL LGTTSSPGGGFCCPQHICSTCCLER-------DLQRASKGRLMRCIRCPVAYHTGDSCVAAGSVVLTHHIMICSSHGST- KRNGLLTSPINVSWCFLCARGLLVQDLTDTILSSYAYKSHYLLTESNR-AEL-KLPMIPSPSSATKKNVGK--GGKLLCC DSCPASFHPECLEM-EMPEG---PWSCSDCRT---------------GKKPHYKQIVWVKLGNYR-WWPAEICNPRLVPS NIQSLRHDIGDFPVFFFGSHDYYWINQGRVFPYVESDK-NFVTGQI--NINKTFKKALEEAARRFQELKAQRESREALEQ ERNSRKPPPYKFIKSNKPVGKVQMHVADLSEIQRCNCRPTDEHPCGLHSQCLNRMLQYECHPQVCPAGDNCENQGFTKRL YAETEVVKTA-DRGWGLKANQPLKK------------------GEFVTEYVGEVIDAEECQQRIKRAHENHMTNFYMLTL TKDRVIDAAQKGNLSRFINHSCSPNCETQKWTVNGDVHIGLFALCDIDAG-TELTFNYNLHCVGNR-RTTCNCGSDNCSG FLGVQPTSA-----VVLEKEEKARNAKLKPKKRKLRLE-GKHTHEYYCFCCGEGGELVMCDRKDCPKAYHLLCLNLTKPP YG-----------RWECPWHDCTI--CSAPASSSCDFCPRSFCQEHEEGALTSSSLEGRLCCSSHDPASPLGSNSCSTQP HCSTSSPLRVKEEPETETDPMAAE-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Tetraodon_nigroviridis_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-GTCDTGSDPGEDGGP-SYDAAL--DSEFSYPPSASEDMSQVSNGYPPGLGLYEPQAKFSMYSQFPNG SANGYGAIRSYGEHGLLPGEGTVLRGPGLQERPLSPVSPP---------------------------------------- ----------------------------------------------VPSNTTGGVLKKTSSPEIKLKIIKTYQNGKELFE SALCGDLLQELQESQKKEAAQMQRRHERKKEKRKKSARLQLQVQEQSQEQSLNQSQVQAGTLTPT--------------- --------------------------------------DDPLMHPQLVETP--QTEKPQKTTVKTVPKTP---------- -------KEFVIGDLVWSKVGTYPWWPCMVSSDPQMKVHTRIN-TRGH---------REYHVQFFGSVAERAWIHEKRIV IYQGKQQFEELQAETLRKATNPVEKQKLMKPIPQRERSQWEVGVGHAEDAFVMTRQERI--------------------- ---------------------DNYTFIYVDPDPNETPP--SKKPNIKAE-KQNRRPSGSVRK------------------ ------------QCSVSNTDDSTNSQASNDDQREDQHSGTSPKQSTGC-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------EVREQPDSPPPVR-A WKTAAARKLLPLSVT---MKRLNVEITKCDWPLLQKKAALSPKN---------------------DPDEN-----RTAGR -------------SLNPALKKMRMGMKGRKR------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------VMTGEGHLPQ TY----SPGSPHSSPQGWQS------------------------------------------------------------ ------------------------------------------------------SGLQGHVLERKLQRRSVRSRSESERG SDP-VPKKKTKKEQAEMAPETTMRTG---------------------------------------SQKGASEISDACKPL KKRSRASTDVEMA-SSQYRDTSDSDSRGLSDPQGLFGKNLDSPAA-ADG--SDTQSVDSGLSRQDSNTDKRDTVCQICEA YGE-GLVVCEGDCSRQFHLECLGLTALPEGRFTCLECLNGKHPCFSCKTAGR------EVTRCSVSGCGCFYHEDCVRKL LGTTSSPGGGFCCPQHICSTCCLER-------DLQRASKGRLMRCIRCPVAYHTGDSCVAAGSVILTHHIMICSSHE--- ERPPHLPR-VNVSWCFLCARGLLVQDLTDTILSSYAYKSHYLLTESNR-AEL-KLPMIPSPSSATKKNVGKDAGGKLLCC DSCPASFHPECLEM-EMPEG---PWSCSDCRA---------------GKKPHYKQIVWVKLGNYR-WWPAEICNPRLVPS NIQSLRHDIGDFPVFFFGSHDYYWINQGRVFPYVENDK-NFVTGQI--NINKTFKKALEEAARRFQELKAQRESREALEQ ERNSRKPPPYKFIKSNKPVGKVQMHIADLSEVQRCNCRPTDEHPCGLQSQCLNRMLQYECHPQVCPAGDNCENQCFTKRL YAETEVVKTA-DRGWGLKANQPIKK------------------GEFVIEYVGEVIDAEECQQRIKRAHENHMTNFYMLTL TKDRVIDAGQKGNLSRFINHSCSPNCETQKWTVNGDVHIGLFALCDIETD-TELTFNYNLHCVGNR-RATCNCGSDNCSG FLGVQPTSA-----VVLEKEEKAKNAKLKPKKRKLRLE-GKHTHEYYCFCCGEGGELVMCDRKDCPKAYHLLCLNLTKPP YG-----------RWECPWHDCTL--CSTPASSFCDFCPRSFCRDHEEGALTPSSLEGRLCCSSHDPSSPL--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gasterosteus_aculeatus_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-GTCD--SDPGEDGGP-SYDAAL--DAEFSYPPSASEDMSHVSNGYPPGLGMYEPQAKFSMYSQFPNG SANGYGAIRSYGDHVLMPGEGTVLRGPGLQERPLSPV------------------------------------------- ------------------------------PPPSLVDNTPSSQPPLGLSNTPDGPLKKTSSPEIKLKIIKTYQNGKELFE SALCG---DLLQELQKDEATPTQRRHERKKEKRKKSAQLQLQEQDLD---QSQEQQAQEGTTEQT--------------- --------------------------------------EDPNAQPRETETPPAPTEKPPKTTIKVEPKTP---------- -KETGFCKEFVIGDLVWSKVGTYPWWPCMVSSDPQMKVHTRIN-TRGH---------REYHVQFFGSVAERAWIHEKRIV LYQGKQQYEDLQAETLRRATNPVEKHKLLKPIPQRERSQWEVGVGHAEDAFAMSRQERI--------------------- ---------------------DNYTFIYVDPDPIEGPS--SRKPTIRAE-KRNRRSSGSVGKKED--------------- -------------ISNADDAANSKASHEDKDQKGD-----SPKPDAGG-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------DAR--QGSPPPVR-A WKTAAARKLLPLSIT---MKRLNVEITKCDWPLLQKKAALSPK--------------------------KEQLVAREARQ PDLGYCSPEDSRAKPEPSQ------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------SPASRRSEEGGMQQ TS----SPGSHHSSPHGSQ------------------------------------------------------------- --------------------------------------------------------------ERKLQRRSVRSRSESERG NDP-VPKKKTKKEQAETAPETTLKTG---------------------------------------SQKGASEISDACKPL KKRSRASTDVEMA-SSQYRDTSDSDSRGLNDPQGLFGKSLDSPAA-ADADASDTQSVDSGLSRQDGSAGKRDTVCQVCEV YGE-GLLVCEGDCGRQFHLDCLSLTAPPEGRFTCLECMNGNHTCFSCKTAGR------EVTRCSVSGCSCYYHEDCVRKL PGTSGGSDGGFCCPQHSCSTCCLER-------DLQRASKGRLMRCIRCPVAYHTGDSCVAAGSVALTHHIMICSNHSGA- KRNGLLTSPINVGWCFLCARGLLVQDLTDTILSSYAYKSHYLLTESNR-AEL-KLPMIPSPSSATKKNVGKDAGGKLLCC DTCPASFHPECLEM-ETPAG---PWSCSDCRA---------------GKKPHYKQIVWVKLGNYR-WWPAEICNPRLVPS NIQSLRHDVGDFPVFFFGSHDYYWINQGRVFPYVENDK-NFVTGQI--NINKTFKKALEEAARRFQELKAQRESREALEQ ERNSRKPPPYKIIKSNKPVGKVQVHVADLSEIQRCNCRPTDEHPCSLNSQCLNRMLQYECHPQVCPAGDSCENQCFSKRL YAETEVIKTD-GRGWGLQTNQALRK------------------GDFVTEYVGEVIDAEECQQRIKRAHENHVADFYMLTL TKDRVIDAGPKGNSSRFMNHSCRPNCETQKWTVNGDVRIGLFTLCDVEAG-TELTFNYNLHCVGNR-RSSCHCGSDNCSG FLGVQPTSA-----VVMEKEEKARNAKLKPKKRKLRPE-GKQTHEYCCFCCGEGGELVMCDRKDCPKAYHLLCLNLTKPP YG-----------RWECPWHDCSQ--CGAPASSLCDFCPSSFCRDHEAGALTSSALEGRPCCPGHDPASPL--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Oryzias_latipes_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQD-GTCDTGSDPGEDSGP-SYDASL--DAEFPYPPSASEVMPQLPNGYPPSLGLYEPQTKF-MYSQFPNG SANGYGALRSYGEHGLLPGEGTVLRGPGLQERPLSPVSPPLPTHHPHLHPHHLHPHHHSFQSNPPHIQTHSHPHSPPPLP LPSQHHLLQTPHIMTHNLPPPPPLHLPSSSPPPSLVDSTPSSQPAHIPSNTPGGVLKKTSSPEIKLKIIKTYQNGKELFE SALCGDLQELQKESQKNEAVLKQRRHERKKEKRKRSARLQAQELKQD---PSP---APPGTTEQP--------------- --------------------------------------EEEQVQLQQKETPLIQTEKPQKTVIETEPKTPKVSKVHHPSV IQETGICKEFVIGDLVWSKVGTYPWWPCMVSSDPQMKVHTRIN-TRGH---------REYHVQFFGSVAERAWIHEKRIV VYQGKQQFDELQAETLRKATNPVERQKLLKPIPQRERSQWEVGVGHAEDAFLMTRQERI--------------------- ---------------------DNYTFIYVDPDPNEAQQ--SKKPSIRPE-KRNRRSSGSVTKKEDRCVKSPDREQQQPQQ QPQPPRRQQPRRRCSVTNTEDSSQASTEERSQKADQRKASSPRLNAGC-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------ETQLQQDSSPPVR-A WKTAAARKLLPLSIT---MKRLNVEITKCDWPLLQKKTSLSPKRA--------------------NAEEKEERGEREARQ PDLGYCSPEDSRAKPEPSPEEEEDADEGEEEGD----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------ERRGSPASQRSEEGGNQQ PS----SPGSQDSSPQGSQ------------------------------------------------------------- --------------------------------------------------------------ERKLQRRSIRSKSESERG TDP-VPKKKTKKEQAEMAPETTLKTG---------------------------------------SQKGASEISDACKPL KKRSRASTDVEMA-SSQYRDTSDSDSRGLSDPQGLFGKSLDSPAA-ADADASDTQSVDSGLSRQDSSNEKRDTVCQICEA YGE-GLMVCEGDCSRQFHPECLGLSAPPDGRFTCLECKNSNHPCFSCKTTGQ------EVSRCSAPGCSCYYHEDCVWKH PGTTSSPGGGFCCPQHSCSTCCLER-------DLQRASKGRLIHCIRCPTAYHTSDVCMAAGSVILTHHIMICSNHGST- KKNGLLSSPVNVGWCFLCARGLLVQDLTDTILSSYAYKSHYLLTESNR-AEL-KLPMIPSPSSATKKNVGK--GGKLLCC DSCPASFHPECLEM-DMPEG---AWSCSDCRA---------------GKKPHYKQIVWVKLGNYR-WWPAEICNPRLVPS NIQSLRHDIGDFPVFFFGSHDYYWINQGRVFPYVENDK-NFVTGQI--NINKTFKNALEEAARRFQELKAQRESREALEQ ERNSRKPPPYKVIKSNKPVGKVQMHVADLSEIPRCNCKPVDEHPCSIDSQCLNRMLQYECHPQVCPAGDNCENQNFTKRL YAETEVVKTE-GRGWGLQTNQALRK------------------GDFVAEYVGEVIDSEECQQRIKRAHENHVTNFYMLTL TKDRVIDAGPKGNSARFINHSCNPNCETQKWTVNGDVRIGIFALCDIEAG-TELTFNYNLHCVGNR-RTSCHCGSENCSG FLGVQPTSA-----LVMEKEEKARNAKLKPKKRKLRLE-GKHTHEYFCFCCGDGGELVMCDRKDCPKAYHLLCLNLTKPP YG-----------RWECPWHDCSV--CGSPASSHCDFCPRSFCTDHEAGALTPSSLDERPCCSSHNPLSPLGSSGS-SQR HSSTLSPVRVKEEPEGEQAAAE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Lepisosteus_oculatus_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DVYDAGSDNGEDGGPSAYETAL--ESGFSYPPSAAEDLPVVTNGYPPNVSLYEPQAKYAMYSQFPNG SANGYSAIRSYSDHCLLQGENTVLRAPVVQEKPPSPSSPSATHHHHPHHQPQQQQQQHHHHHHHP--------------- -----HPHPPPPHMNPSVLPPPPPLLLPSSPPPSLATIITS-----PPHPQPPATPKKTSSPEIKLKIIKTYQNGRELFE SSLCGDLLHEFQASEAS-----RRRHERKKEKRKKSSRHSLHRDPEEQ-QQQHELCVPEPAPEPV--------------- --------------------------------------PEPLCEPLDVHRPKLEFSPRNRTCPEAEPKEHKIQK-HFPTV ITGTGCCKDHEVGDLVWAKVGTYPWWPCMVSCDPQSDVHTRIN-TRGH---------REYHVQFFGSVPERAWIHEKRVV VYQGRHQFEQLQADTLRRASNPAERHKLLKPIPQRERAQWEVGIGHAEDAFQMTREERI--------------------- ---------------------ENYTFIYVDKEPETSPPP-AEKPTSKADNRRARRTRSAVSSPRPDP-----SGEVSSAR PGLPPRRQQPRRQCSMTNSEEP--PQPAQPEQDEQQPRCPVPQNQPSE-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------EPKDQGAQQPPVKTA WKTAAARKLLPLSIT---MKKLNVEIQKCDWPLPRDRTPSPQES------------------------------EGEDKP SDQPVCPPRGASSKPEMSSKEQERLVSPVGR------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------RSDPG-MVQ HS----STAEVSSG------------------------------------------------------------------ ------------------------------------------------------------LLERKQQRRSVRSRSESEKG TDP-VPKKKMKKEQTEMVPQAALKTG---------------------------------------SQKGASEISDSCKPL KKRSRASTDVEMA-SYQYRDTSDSDSRGLNDSQVGFGKRSDSPTA-ADADASDAQSVDSSLSRQGTSTTKKDTVCQICEN FGD-TLVSCEGDCSRLFHLECLGLTSLLEGKFTCMECKNGAHSCFSCKASGS------DVKRCSVSGCGRFYHESCVRKH ANATFESKG-FRCPQHSCATCALER-------DMHKASKGRMMRCIRCPTAYHTGDSCFAAGSVVITPHIIICSNHSSS- KKNGHITSPVNVGWCFVCARGLLVQDNSDNIFSSYAYKSHYLLTESNR-AELMKLPMIPSSSSATKKNCGK--GGRLLCC ESCPASFHPECLNI-EMPDG---IWFCNECRI---------------GKKPHYKQIVWVKLGNYR-WWPAEICNPRLVPF NIQTLKHDIGDFPVFFFGSHDYYWINQGRVFPYVEGDK-NFADGQI--GINKTFKKALEEAAKRFQELKAQRESKEALEQ ERSSRKPPPYKFIKSNKPVGKVQIHVADLSEIPRCNCKPTDENPCSLDSECLNRMLQYECHPQVCPAGENCQNQCFTKRL YPETEVIKTE-GRGWGLKTKKSLKK------------------GEFVTEYVGELIDSEECRQRIKHAHENHVTNFYMLTL TKDRVIDAGPKGNYSRFMNHSCSPNCETQKWTVNGDVRVGLFALCDIETE-TELTFNYNLDCLGNG-RTTCHCGAENCSG FLGVRPKSA-----VVIEKEEKAKNAKLKAKKRKIKPE-AKQNHEYFCFCCGEGGELVMCDKKDCPKAYHLLCLNLTKPP YG-----------RWECPWHQCSV--CGRSSISFCEFCPSSFCKDHEKGALVPSALEGRLCCSSHNPKNPLT-------- -PESLNKVKVKLEPLDPPDAMGE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Latimeria_chalumnae_NSD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------MYIAINTSCKLPFFSPQMKEHLPA--------------- --------------------------------------VVK--------------------------------------- ---MNVEVIYQVGDLVWSKVGTYPWWPCMVSLDPQLQVHTKTN-ARGG---------REYHVQFFGSIPERAWVYEKRVQ EYKGHSQYDQLLAEAARKATNHAEKQKILKPIPQRERAQWEVGIAHAEEALKMTKEARI--------------------- ---------------------EQYTFIYVDEEPGAPASTEKHNCA-KTEAKKGRKHRTAMSP------------------ ------------VSEQPTVEEEPQMSPSTEGRRQRLRRQSVVVEP----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------PIKMV WKTAAARKSLPASLI---MQMGNQEGQNHETPLTENKNLVLSIQG----------------------------SGADGRL TEKFN-ATKGATNKTETDK-GQDKHI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------VTPASQKNERAS LQ---HTISETASG---SL------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSVRSRSESERS ADA-VPKKKVKKEQVEILPQAAVKTGSQKEDVFSFHDGGCRLV-----------------LKPVVWRLGASEISDSCKPL KKRSRASTDVEVT-SLTYRDTSDSDSRGLNEVQVGFGKSADSPSAVADAEASDSQSVDSSLSRRGTGTTKKDTVCQICAS FGE-SLVTCEGECYRLFHMECLGLTALPEGKFICIECKAGSHTCFSCKVPGT------DVKRCSVNACGRFFHESCARKY STSMFESKG-FRCPQHCCTTCSIDK-------DIHKASKGRMMRCLQCPVAYHTGDSCVVAGSVVLTPHIIICSDHS--- KRSSHSVPAVNVGFCFVCSRGLLVQDLSDPLLSAYANKSHYLLSESYR-AELMKLPMIPSSSSASKKKVEK--GGRLLCC ESCPASFHPECLNI-EMPEG---SWYCNECKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICSPRSVPH NIQGIKHDIGDFPVFFFGSHDYYWVHRGRVFPYVEGDK-SFAEGQI--SGSKTFKKALDEAAKRFQELKAQRESKEALEN ERNSRKPIPYKHIRTNKPVGKVQIHIADLSEIPRCNCKPDDENPCGLDSECLNKMLQYECHPQVCPAAEHCQNQSFSKRL YPETEVIKTE-GRGWGLQTKCNIRK------------------GEFVNEYVGELIDEQECRSRIKKAHENNVTNFYMLTL TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDISAG-TELTFNYNLDCLGNG-RTKCYCAAENCSG FLGVRPKTA-----CATATEEKAKIAKLKQKKRKIKLE-RSQMHEDYCFHCGDGGELVMCDKKDCPKAYHLLCLNLTKPP VG-----------RWECPWHQCSE--CNSPAVSHCEFCPSSFCKDHEKGSLVSSALEGRLCCSKHDPKCPVA-------- -PESWAWMKCKTEPQDTGEEPTE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Pan_troglodytes_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIAEDGGQTPYEATL--QQGFQYP-ATTEDLPQLTNGYPSSISVYETQTKYQSYNQYPNG SANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQP------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVDTVSEKPREEPVLKEEAPVQPILSSVPTTE---------- ---VSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYIDKQPEEALSQAKKNVASKTEVKKTRRPRSVLNT------------------ ------------QPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTPNQRNEKPT QS---VSSPEATSGSTGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQATVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICES SGD-SLIACEGECCKHFHLECLGLTSLPDSKFICMECKTGQHPCFSCKVSGK------DVKRCSVGACGKFYHEACVRKF PTAIFESKG-FRCPQHCCSACSMEK-------DIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHS--- KRSSNSS-AVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC ESCPASFHPECLSI-EMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKSA-----CASTNEEKAKNAKLKQKRRKIKTE-PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCDE--CSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVS-------- -PEYWSKIKCKWESQDHGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Gorilla_gorilla_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIAEDGGQTPYEATL--QQGFQYP-ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNG SANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQP------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHM-----KSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVDTVSEKPREEPVLKEEAPVQPILSSVPTTE---------- ---VSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYIDKQPEEALSQAKKNVASKTEVKKTRRPRSVLNT------------------ ------------QPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTPNQRNEKPT QS---VSSPEATSGSTGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQATVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICES PGD-SLIPCEGECCKHFHLECLGLTSLPDSKFICMECKTGQHPCFSCKVSGK------DVKRCSVGACGKFYHEACVRKF PTAIFESKG-FRCPQHCCSACSMEK-------DIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHS--- KRSSNSS-AVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC ESCPASFHPECLSI-EMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKSA-----CASTNEEKAKNAKLKQKRRKIKTE-PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCDE--CSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVS-------- -PEYWSKIKCKWESQDHGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Otolemur_garnettii_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIAEDGGQIPYEATL--QQGFQYP-STTEDLPPLTNGYPPSISIYETQTKYQSYNQYPNG SANGFGAVRNFSPTDYYHSEIPNTRPQEILEKPSPPQP------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVDPASEKPREDPVLKGEAPVQPILSSVPTTE---------- ---VSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPLLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERV--------------------- ---------------------EQYTFIYIDKQPEEALSQAKKSVAAKAEAKKTRRPRSVLTT------------------ ------------QPEQTDAGEAASSPSGSETRRHSQRRHTSVEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ITAPNQRNEKPT QN---TSSPEATSGSTGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVEMVPQATLKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLSDLQVGFGKQGDSPSATADADVSDVQSVDSSLSRRGVGMSKKDTVCQICES SGD-SLTPCEGECCKHFHLECLGLTSVPDGKFICTECKTGQHPCFSCKVSGK------DVKRCSVGACGKFYHEACVRKF PTAIFESKG-FRCPQHCCSACSMEK-------DIHKASKGRMLRCLRCPVAYHSGDACVAAGSVFVSSCILICSGHA--- RRNSSSAAAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC DSCPASFHPECLSM-DVPEG---CWNCSDCRT---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRAVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYIEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGERCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKSA-----CASTNEEKAKNAKLKQKRRKVKTE-PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCAE--CGSAAVSFCEFCPRSFCKDHEKGALVPSALEGRLCCSEHDPRSPVS-------- -PEYWNKIKCKWESQDRGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Macaca_mulatta_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIAEDGGQTPYEATL--QQGFQYP-ATTEDLPPLTNGYPSSISVYETQTKYQSYSQYPNG SANGFGAARNFSPTDYYHSEIPNTRPHEILEKPSPPQP------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVDTVSEKPREDPVLKEEAPVQPILSSVPTTE---------- ---VSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHSKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYIDKQPEEALSQAKKNVASKTEVKKTRRPRSVLNT------------------ ------------QPEQTSAGEVASSLSSTEIRRHSQRRHTSAEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTPNQRSEKPT QS---ISSPEATSGSTGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQATVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICES SGD-SLIPCEGECCKHFHLECLGLTSLPDSKFVCMECKTGQHPCFSCKVSGK------DVKRCSVGACGKFYHEACVRKF PTAIFESKG-FRCPQHCCSACSMEK-------DIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHS--- KRSSNSSAAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC ESCPASFHPECLSI-EMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKSA-----CASTTEEKAKNAKLKQKRRKIKTE-PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCDE--CSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVS-------- -PEYWSKIKCKWESQDHGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Bos_taurus_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIVEDGGQTPYEATL--QQGFQYP-PTTEDLPPLTNGYPPSISMYETQTKYQSYNQYPNG SANGFGTVRNFSPSDYYHSEIPNTRPHEILEKPSPPQPP----------------------------------------- --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVDPVSEKPREDPVLKEETPVQPMLPSVPTAE---------- ---ASAGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATRQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALTMTREERI--------------------- ---------------------EQYTFIYIDKQPEETLSQAKKNVVSKAEVKKPRRPRSVLNV------------------ ------------QPEQTNAGEAASSPSGTEMRRHSQRRHTGVDEDE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKVA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTPNQRNEKAT QN---MSSPEATSGSAGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQATVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMA-GSTYRDTSDSDSRGLSDLQAGFGKQVDSPSATAEADVSDVQSVDSSLSRRGTGMSRKDTVCQICES SGD-SLIPCEGECCKHFHLECLGLSSPPDGKFVCVECKTGQHPCFSCKVSGA------DVKRCSVSACGKFYHEACVRKF PTAVFESKG-FRCPQHCCSACSMEK-------DIHKASKGRMVRCLRCPVAYHSVDACIAAGSTLVSSCVLICSNHS--- TRSSGSSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC ESCPASFHPECLSI-ETPEG---CWNCNDCKA---------------GKKLHYKQIVWAKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFADGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKSSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGERCQNQCFTKRL YPDAEVIRTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHEN---------- -SDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGADNCSG FLGVRPKSA-----CASTAEEKAKNAKLKPKRRKIKTE-PKQLHEDFCFQCGDGGELVMCDRKDCSKAYHLLCLNLPQPP YG-----------KWECPWHQCDE--CSAAAVAFCEFCPRSFCKDHEKGALVPSALEGRLCCSEHDPASPVS-------- -PEYWSKIKCKLESQDHGEEVKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Felis_catus_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIVEDGGQTPYEATL--QQGFQYP-PTTEDLPPLTNGYPPSISMYETQTKYQSYNQYPNG SANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQP------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RIDTVSEKPRDDPVLKEEPPVQPILSSVPTTE---------- ---VSAGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYIDKQPEEALSQAKKNVASKAEVKKTRRPRSVLNT------------------ ------------QPEQTDAGEVASSPSSTEIRRQSQRRHTSVEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTPNQRSEKAT QN---ISSPEATSGPTGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQATVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADVDVSDVQSVDSSLSRRGIGISKKDTVCQICES SGD-SLIPCEGECCKHFHLECLGLASLPDGKFICVECKTGQHPCFSCKVSGT------DVKRCSVGACGKFYHEACVRKF PTAIFESKG-FRCPQHCCSACSMEK-------DIYKASKGRMMRCLRCPVAYHSGDACIAAGSIFVSSYILICSNHS--- KRSSSSSSAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC ESCPASFHPECLSI-EMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESKEALEI EKNSRKPPPYKHIKANKVIGKVQIHVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGERCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGAENCSG FLGVRPKPT-----CASTTEEKAKNAKLKQKRRKIKAE-PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCGE--CGSAAVSFCEFCPRSFCKDHREGALVPSALEGRLCCSEHDPESPVS-------- -AEYWSKIKCKLESQDRGEDLRE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Canis_lupus_familiaris_NSD3 -------------------------------------------------------------MDFSFSFMQGIMGNTIQQP PQLIDSANIRQE-DAFDNNSDIVEDGGQTPYEATL--QQGFQYP-PTTEDLPPLTNGYPPSISMYETQTKYQSYNQYPNG SANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQL------------------------------------------ --------------------------------------------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFE SSLCGDLLNEVQASEHT-----KSKHESRKEKRKKSNKHDSCRSEERKSHKIPKLEPEEQNRPNE--------------- --------------------------------------RVDTVSEKPREEPVPKEEPPVQPILSSVPTTE---------- ---VSAGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN-TRGA---------REYHVQFFSNQPERAWVHEKRVR EYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERI--------------------- ---------------------EQYTFIYIDKQPEEALSQGKKNVASKAEVKKTRRPRSVLNT------------------ ------------QLEQTNAGEVASSLSSTEIRRQSQRRHTSVEEEE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------PPPVKIA WKTAAARKSLPASIT---MHKGSLDLQKCNMSPVVKIEQVFALQN----------------------------ATGDGKF IDQFVYSTKGIGNKTEISVRGQDRLI------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------ISTPNQRNEKAT QN---ISS-EATSGPTGSV------------------------------------------------------------- --------------------------------------------------------------EKKQQRRSIRTRSESEKS TEV-VPKKKIKKEQVETVPQATVKTG---------------------------------------LQKGASEISDSCKPL KKRSRASTDVEMT-SSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSVDSSLSRRGIGVSKKDTVCQICES SGD-SLIPCEGECCKHFHLECLGLASVPDGKFICIECKTGQHPCFSCKVSGT------DVKRCSVGACGKFYHEACVRKF PTAIFESKG-FRCPQHCCSACSMEK-------DIYKASKGRMMRCLRCPVAYHSGDACIAAGSIFISSYNLICSNHS--- KRKSSSSSAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNR-AELMKLPMIP-SSSASKKKCEK--GGRLLCC ESCPASFHPECLSI-EMPEG---CWNCNDCKA---------------GKKLHYKQIVWVKLGNYR-WWPAEICNPRSVPL NIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQT--SINKTFKKALEEAAKRFQELKAQRESREALEI EKNSRKPPPYKHIKANKVIGKVQIHVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGERCQNQCFTKRL YPDAEIIKTE-RRGWGLRTKRSIKK------------------GEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDIRVGLFALCDIPAG-MELTFNYNLDCLGNG-RTECHCGAENCSG FLGVRPKST-----CVSTTEEKAKNAKLKQKRRKIKAE-PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPP YG-----------KWECPWHQCEE--CSSAAVSFCEFCPHSFCKDHEEGALVPSALEGRLCCSEHDPACPVS-------- -AEYWSKIKCKLESQDHGEELKE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- - >Callorhinchus_milii_NSD3 -------------------------------------------------------------MDLSYSFMKGIMGNTIQLP QQLIDSANMRQVPDVLNAASGIGEDRGQ-TYEASL--QQGFIYPASSADSIPPVTNGYAS-VNLYDAPNKYAGYSQLPNG SANGYGTYRNLASADYYAVENCIVKPPEIQEKAPSPPA------------------------------------------ --------------------------------------------------SEPATPKKTGSPEIKLRITKTYHNGKALFE SSLCGDLLNEEQAQSQAQSP--LAAAREQKREKKKRKKHDSCSGEEQTRKKVIKAEPEEHKVSPF--------------- --------------------------------------GGVDSTGTMGRIAFSHYKYSIQPALGSLPCVG---------- -----GVPQYQIGDLVWSKVGTYPWWPCMVSSDPLLQIHTKIN-TRGA---------REYHVQFFGSIPERAWVHEKRVA PYKGCSQYEILVAETARQASSTAEKQKILKPIAQRVRPQWDVGIAQVEEALKMTLEDRI--------------------- ---------------------AQYTFIYVDPPLETSLESNKSPATLKSEVKRSRKPRMFPRA------------------ --------------EQEESERHLDSPSPASAGDGNGHGHPGEREAP---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------KMA WRTAAARKSLPPSLANLKVEKRNGGSSDCDVLPVAKSDQVLSVQE--------------------------------QGT PGTCVNQYLGTCIKTDVSGREVDKAG------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------KPTPNQKPF VS--------GVNRLPGSL------------------------------------------------------------- --------------------------------------------------------------ERKQQRRCVRSRSESEKS VEA-VPKKKMRKEQVRMLLLLFVGAS---------------------------------------------ELSDACKPL KKRSRASTDVEMT-SSSYREVNDSDCRG----LVSEGAIRDSIGACIEISVESSISR----SQRCVRTVLRPLSLKICEK PGE-SLVPCEGECCRVFHLECLGLAELPNGKFTCMECTTGNHTCFSCKVSGK------IVKRCSVNSCGRFYHESCLRSY STAMFEGKG-FRCPLHCCLACLADNR------EIAKATKGRMLRCLRCPTAYHTGEGCIAAGSLVLSNHSIICNNHSSAK KGNRAALSHVNVSWCFICARGVIEQHQSESLFSSYAYKSHYLLSESNRSAELLKLAMIPPSPSATVKKCGK--GGHLLCC ESCPASFHPECLNI-EMPEG---SWYCNDCKA---------------GKKPRYKEIVWVKLGIYR-WWPAEICNPKSVPL NIQAMKHHIGEFPVRFFGSNDYYWVHQGRVFPYLEGDKGNVSDGRT-GSINETFKKALEETTKRFRELKALRESKEALEN ERNERKPPAYRFVKTNKPIGKVQIYTADLSEIPRCNCKPTDESPCGLESECLNRILMYECHADVCPAGEHCQNQSFSKRL YPDTELVKTE-GRGWGLRTKVDIKK------------------GQFVNEYVGELVDEEECRKRIKHAHENNVTNFYMLTL TKDRVIDAGPKGNYSRFMNHSCNPNCETQKWTVSGDTRVGLFALCDVRAG-SELTFNYNLDCLGNG-KTICKCGAPNCSG YLGVRPKTA-----AATANEEKAKNAKKKMKRRKTKMD-VRKMHEDYCYRCGDGGELVMCDKKDCPKAYHLSCLNLTKPP FG-----------KWECPWHHCDE--CGNPATTFCDFCPNSYCREHQKGSFTACGLDGRLCCSDHEPGFHAEFD------ -RASSVSLPNHSATEDTSEEALE--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -