>Homo_sapiens_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MSLGLAGAQEVELTLETVIQTL ESSVLCQE-------------------------------------------KGLGARDLAQDA-QITSLPALIREIVTRN LSQPESPVLLP------ATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN-------------------- -------------------------------------------------AVSERLEQALRLEPGELETQEP--RGLVRQS VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQRLRDTEH---- ----------------------------------------------------------------------SQDLESALIR LEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFN---AYFSNEHSRLLL LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQAL---LQAQLEEQLRDKV LREKDLAQQQMQSDLDKADLS-------ARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA---------LESLRLQEQA ALETEDGEG-------LQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG-------- ------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL RD----KTDGAMQAHEDAQREVQRLRSANELLS----------------------------REKSNLAHSLQVAQQQAEE LRQER----------EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR--ELERSHRQLEQ-------LEGKRSVLAKEL VEVREALSRATLQRDMLQAEKAEVAEALTKAE-AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ -------------------------LEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE ALEQQLPTLRHERSQLQ---------------------EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA KEHAGLAVQLVAAEREGRTLSEEATR-----LRLEK--EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTG-- --ELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ------ASLREQRAAHEEDLQR--LQREKEAAWRELEAERAQL QSQLQREQEELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES------------------------- --------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLATISLEMER QKRDAQSRQEQDRS-------TVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLR------------- ----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKLRESQEGREVQRQEAGELRRS LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE LRRQMK-------------------------------------------------------------------------- ------------------------------------------------------------------------MLDSENTR LGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEV---MRQELQVAQRKLQEQEGEFRTRE----------RR LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR-AAEAQLGGLRSALRRGL GLGRAPSP-----------------------------APRPVPGSPARDAPAEGSGEGLNSPST-------LECSPGSQP PSPGPATSP------------------------------------------------------------------ASPDL DPEAVRGALREFLQELRSAQRE----RDELRTQTSALN-RQLAEMEAERDSATSRARQLQKAVAESEEARRS---VDGRL SGVQAEL-ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK--------------------- ------------LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVDSLQRQVADSEV KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR----DKNLHLQKALTACEHDRQVLQERLDAAR QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE------------------------------ -------------------------------------------------------------------------------- -----------GEAAALNT-VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV----------------------------------------- -------------------------------------------------------------------------------- --VVLEQSHSPAQLEVDAQQQQ--LELQQE------VERLRSAQAQTERTLEARERAHRQRVRGLEEQ-VSTLKGQLQQE LRRSSAPFSPPSGPPEK--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Pan_troglodytes_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MSLGLAGAQEVELTLETVIQTL ESSVLCQE-------------------------------------------KGLGARDLAQDA-QITSLPARIREIVTRN LSRPESPVLLP------ATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN-------------------- -------------------------------------------------AVSERLEQALQLESGELETQEP--RGLVRQS VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQRLRDTEH---- ----------------------------------------------------------------------SQDLESALIR LEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFN---AYFSNEHSRLLL LWRQVVGFRQLVSEVKMFTARDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQAL---LQAQLEEQLRNKV LREKDLVQQQMQSDLDKADLS-------ARVTELALAVERLQKQNLEKDQVNKDLTEKLEA---------LESLRLQEQA ALETEDGEG-------LQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG-------- ------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL RD----KTDGAMQAHEDAQREVQRLRSANELLS----------------------------REKSNLAHSLQVAQQQAEE LRQER----------EKLQAAQEELRRQRDRLEEEQEDAVQDGVRVRR--ELERSHRQLEQ-------LEGKRSVLAKEL VEVREALSRATLQRDMLQAEKTEVAEALTKAE-AGRVELELSMTRLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ -------------------------LEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE ALEQQLPTLRHERSRLQ---------------------EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA KERAGLAVQLVAAEREGRTLSEEATR-----LRLEK--EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTG-- --ELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ------ASLREQRAAHEEDLQR--LQREKEAAWRELEAERAQL QSQLQREQEELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES------------------------- --------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLATISLEMER QKRDAQSRQEQDRS-------TVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLL------------- ----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKLRESQEGREVQRQEAGELRRS LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE LRRQMK-------------------------------------------------------------------------- ------------------------------------------------------------------------MLDSENTR LGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEV---MRQELQVAQRKLQEQEGEFRTRE----------RR LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR-AAEAQLGGLRSALRRGL GLGRAPSP-----------------------------APRPVPGSPARDAPAGGSGEGLSSPST-------LECSPGSQP PSPGPATSP------------------------------------------------------------------ASPDL DPEAVRGALREFLQELRSAQRE----RDELRTQTSALN-RQLAEMEAERDSATSRARQLQKAVAESEEARRS---VDGRL SGVQAEL-ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK--------------------- ------------LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVDSLQRQVADSEV KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR----DKNLHLQKALTACEHDRQVLQERLDAAR QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE------------------------------ -------------------------------------------------------------------------------- -----------GEAAALNT-VQKLQDEQRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV----------------------------------------- -------------------------------------------------------------------------------- --VVLEQSHSPAQLEVDAQQQQ--LELQQE------VERLRSAQAQTERTLEARERAHRQRVRGLEEQ-VSTLKGQLQQE LRRSSAPFSPPSGPPEK--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Gorilla_gorilla_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MSLGLAGAQEVELTLETVIQTL ESSVLCQE-------------------------------------------KGLGARDLAQDA-QITSLPARIREIVTRN LSRPESPVLLP------ATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN-------------------- -------------------------------------------------AVSERLEQALRLESGELETQEP--RGLVRQS VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQRLRDTEH---- ----------------------------------------------------------------------SQDLEGALIR LEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTSDWTRSRKELEHREAAWRREEESFN---AYFSNEHSRLLL LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTDLRLAESRAEAALEKQAL---LQAQLEEQLRDKV LREKDLAQQQMQSDLDKADLS-------ARVTELSLAVKRLQKQNLEKDQVNKDLTEKLEA---------LESLRLQEQA ALETEDGEG-------LQQTLRDLAQAVLSDSESGVQLSGSERTTDASNGSLRGLSGQRTPSPPRRSSPGRG-------- ------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL RD----KTDGAMQAHEDAQREVQRLRSANELLS----------------------------REKSNLAHSLQVAQQQAEE LRQER----------EKLQAAQEELWCQRDRLEEEQDDAVQDGARVRR--ELERSHRQLEQ-------LEGKRSVLAKEL VEVREALSRATLQRDMLQAEKAEVAEALTKAE-AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ -------------------------LEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE ALEQQLPTLRHERSRLQ---------------------EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA KERAGLAVQLVAAEREGRTLSEEATR-----LRLEK--EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTG-- --ELAGLRQQIIATQEKASLDKELMAQKLVQAEWEAQ------ASLWEQQAAHEEDFQR--LQHEKEAAWRELEAERAQL QSQLQREQEELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES------------------------- --------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLATISLEMER QKRDAQSRQEQDRS-------TVNALTSELRDLRAQREEAAAAHTQEVRRLQEQARDLGKQRDSCLR------------- ----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKLRESQEGREVQRQEAGELRRS LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE LRRQMK-------------------------------------------------------------------------- ------------------------------------------------------------------------MLDSENTR LGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEV---MRQELQVAQRKLQEQEGEFRTRE----------RR LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR-AAEAQLGGLRSALRRGL GLGRAPSP-----------------------------APRPVPGSPARDAPAGGSGEGLSSPST-------LECSPGSQP PSPGPATSP------------------------------------------------------------------ASPDL DPEAVRGALREFLQELRSAQRE----RDELRTQTSALN-RQLAEMEAERDSATSRARQLQKAVAESEEARRS---VDGRL SGVQAEL-ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK--------------------- ------------LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVDSLQRQVADSEV KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR----DKNLHLQKALTACEHDRQVLQERLDAAR QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE------------------------------ -------------------------------------------------------------------------------- -----------GEAAALNT-VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV----------------------------------------- -------------------------------------------------------------------------------- --VVLEQSHSPAQLEVDAQQQQ--LELQQE------VERLRSAQAQTERTLEARERAHRQRVRGLEEQ-VSTLKGQLQQE LRRSSAPFSPPSGPPEK--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Mus_musculus_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MSLGLAGSLQAQLALEIVIQSL ENCVLGPNQE-----------------------------------------KSLSVQNRVQDF-QGASLLVCAREVIASN LSRPETPAPLQ------VPEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN-------------------- -------------------------------------------------AVNERLEQAVRLETGELEAQEP--RGLVRQS VELRRQLQEEQS----SYRRKLQAYQEGQQRQAQLVQRLQAKILQYKKQCSELEKQLMDRSTELE--QQRLRDTEH---- ----------------------------------------------------------------------SQDLDSALLR LEEEQQRSASLAQVNAMLREQLDQANLANQALSEDIRKVTSDWTRSCKELEQREAVWRREEESFN---TYFSSEHSRLLR LWRQVMGLRRQASEVKMGTERDLLQLGGELVRTSRAVQELGLGLSASLHRAESKAEAALEKQKL---LQAQLEEQLQAKL LREKDLAQLQVQSDLDKADLS-------ARVTELALSVEHLQNQNSEKDQVNRTLSDKLEA---------LESLRLQEQT TLDTEDGEG-------LQQTLRDLAQAALSDTESGVQLSSSERTADTSDGSLRGFSGQRTPTPPRHS-PGRG-------- ------RSPRRGLSP-----ACSDSSTLTLIHSALHKRQLQVQDMRGRYEASQELLGSVRKQLSDSEGERRGLEEQLQRL RD----QTAASAQAQEDAQREAQRLRSANELLS----------------------------REKGNLTHSLQVTQQQAKE LRQEL----------EKLQAAQEELKRQHNQLEDAQEDSVQEGARARR--ELERSHRQLEQ-------LEVKRSGLTKEL VEVREALSCAILQRDVLQTEKAEVAEALTKAE-AGRAQLELSLTKLRAEEASLRDSLSKMSALNESLAQDKLELNRLIAQ -------------------------LEEEKVALLGRQQQAEHATTMAVEKQELLEQLRLEQEVERQGLQGSLCVAEQARE ALEQQILVLRSERSHLQ---------------------EQLAQLSRQLSGRDQELEQALRESQRQVEALERAAREKEAMA KERAGLAVKLAAAEREGRTLSEEAIR-----LRLEK--EALESSLFDVQRQLAQLEARREQLEADSQALLLAKETLTG-- --ELAGLRQQVTSTEEKAALDKELMTQKLVQAEREAQ------ASLREQRAAHEEDLQR--LQHEKEAAWRELQAERAQL QGQLQQEREELLARM-------------EAEKEELSKEIAALQQERDEGLLLAES------------------------- --------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLAAISLEMER QKRDAQSRQEQDRN-------TLNALTSELRDLRAQLEEATAAHAQTVKELEERTGNLGRQREACMR------------- ----------------EAEEL-------------RTQLRVLEDTRDG-LRRELLEAQRKGRDSQDSSEAHRQEASELRRS LSEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARVSVAKEAGELRASLQEVERSRLEARRELQE LRRQMK-------------------------------------------------------------------------- ------------------------------------------------------------------------TLDSDNGR LGRELADLQGRLALGERTEKESRREALGLRQRLLKGESSLEA---LKQELQGSQRKLQEQEAEFRARE----------RG LLGSLEEARGAEKRLLDSARSLELRLEAVRAETSELGLRLSAAEGRAQGLEVELARVEAQRR-VAEAQLGGLRSALRRGL GLGRVSSS-------------------------------------PAREAPAGGSGDGLSSPSP-------LEYSPRSQP PSPGLIASP------------------------------------------------------------------APPDL DPEAVRDALRDFLQELRSAQRE----RDELKVQTSTLS-QQLVEMEAERDHAASRAKQLQKAVAESEEAWRS---ADRRL SGAQAEL-ALQEESVRRSKRECRATLDQMAVLERSLQATESELRASQEKVSKMKATEAK--------------------- ------------LESDKRRLKEVLDASESRSIKLELQRRALEGELQRSRLGLGDREAHAQALQ--DRVDSLQRQVADSEV KAGTLQLTVERLSGALAKVEESEGNLRSKVQSLTDALTQSSASLSSTQ----DKNLHLQKALSTCEHDRQVLQERLDAAR QALSEARRQSSSLGEQVQTLRGELASLELQRGDAEGQLQQLQQALRQRQE------------------------------ -------------------------------------------------------------------------------- -----------GEAMALRS-VQKLQEERRLLQERLGSLQRALAQLEAEKRDLERSALQFDKDRVALRKTLDKVEREKLRS HEDTLRLNAERGRLDRTLTGAELDLAEAQQQIQHLEAQVD---------------------------------------- -------------------------------------------------------------------------------- --VALEGNHNPVQPEAGEQQ----LELQQE------VERLRSAQVQTERTLEARERAHRQRVSGLEEQ-VSTLKAQLHQE LRRSSASVSLPPGTPEK--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Rattus_norvegicus_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------MASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN-------------------- -------------------------------------------------AINE--------------------------- -----------------------------------------------------------------------RDTEH---- ----------------------------------------------------------------------SQDLDRALLR LEEEQQRSASLAQVNDMLREQLDQANLANQTLSEDICKVTSDWTRSCKELEQREATWRREEESFN---AYFSSEHSRLLL LWRQVMGLRRMASEVKMGTERDLLQLGGELVRTSRAVQEVGLGLSASLQRAESRAEAALEKQKL---LQAQLEEQLRAKL LREKDLAQLQVQSDLDKADLS-------ARVTELALSVEHLQNQNTEKDQVNRTLSDKLEA---------LESLRLQEQT TLDTEDGEG-------LQQTLRDLAQAALSDTESGVQLSNSERTADTSDGSFRGLFGQRTPTPPRHSSPGRG-------- ------RSPRRGLSP-----ACSDSSTLTLIHSALHKRQLQVQDMRGRYEASQDLLGSVRKQLSDSEGERRGLEEQLQRL RD----QTATSVQAQEDAQREAQRLRSANEILS----------------------------REKGNLSHSLQVAQQQAED LRQEL----------EKLQAAQEELRRQHTQLEDQQEDTVQEGARARR--ELERSHRQLEQ-------LEVKRSGLTKEL VEVREALSCAVLQRDVLQTEKAEVAEALTKAE-AGRAQLELSVTKLRAEEASLRDSLSKMSALNESLAQDKLELNRLIAQ -------------------------LEEEKAALLGRQQQAEHATSLAVEKQERLEQLRLEQEVERQGLEGSLCVAEQARE ALGQQILVLRSERSHLQ---------------------EQVAQLSRQLNGRDQELDQALRESQRQVEALERAAREKEAMA KERAGLAVQLAAAEREGRTLSEETIR-----LRLEK--EALESSLFDVQRQLAQLEARREQLEADSQALLLAKETLTG-- --ELAGLRQQVTATEEKAALDKELMTQKLVQAERETQ------ASLREQRAAHEEDLQR--LQREKEAAWRELQAERAQL QGQLQQEREELLARM-------------EAEKEELSEEIAALQQERDEGLLLAES------------------------- --------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLAAISLEMER QKRDAQSRQEQDRN-------TVNALTSELRDLRAQLEEATAAHAQQVKELQEQTGNLGRQREACMR------------- ----------------EAEEL-------------RTQLRLLEDTRDG-LRRELLEAQRKVRDSQDSSEAHRQEASELRRS LSEGTKEREALRRSNEELRTAVKKAESERISLKLANEDKEQKLALLEEARMSVAKEAGELRASLQEVERSRLEARRELQE LRRQMK-------------------------------------------------------------------------- ------------------------------------------------------------------------TLDSDNGR LGRELADLQSRLALGERTEKESRREVLGLRQKVLKGESSLEA---LKQELQGSQRKLQEQEAEFRARE----------RG LLGSLEEARGAEKKLLDSARSLELRLEGVRAETSELGLRLSAAEGRAQGLEVELARVEAQRR-VAEAQLGGLRSALRRGL GLGRVSSS-------------------------------------PAREAPAGGSGDGLSSPSP-------LEYSPRSQP PSPGPVASP------------------------------------------------------------------APPDL DPEAVRDALRDFLQELRSAQRE----RDELRVQTSTLS-QQLAEMEAERDHAASRAKQLQKAVAESEEAWRS---ADRRL SGAQAEL-ALQEESVRRSRRECRATLDQMAVLERSLQATESELRASQEKVNKMKATEVK--------------------- ------------LESDKRRLKEVLDASESRSIKLELQRRALEGELQRSRLGLGDREAHAQALQ--DRVDSLQRQVADSEV KAGTLQLTVERLSGALAKVEESEGTLRSKVQSLTDALAQSSASLTSSQ----DKNLYLQKALSTCEHDRQVLQERLDAAR QALSEARRQSSSLGEQVQTLRGELANLELQRGDAEGQLQQLQQVLRQRQE------------------------------ -------------------------------------------------------------------------------- -----------GEAVALRS-VQKLQEERRLLQERLGSLQRALAQLEAEKRELERSALQLDKDRVALRKTLDKVEREKLRS HEDTLRLNAERGRLDRTLTGAELDLAEAQQQIQHLEAQVV---------------------------------------- -------------------------------------------------------------------------------- --EVLERNHSPVQVEADEQH----LELQQE------VERLRSAQVRTERTLEARERAHRQRVSGLEEQ-VSTLKAQLHQE RHRSSASMSPPSGTPEK--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Canis_familiaris_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MSLGLEESSEAQPTLETVIQTL ESSVLRAGQE-----------------------------------------EGLSAQDPAQDAPRTAGLPARIREIVTRN LSQPDSQAPLP------ATEMASVLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN-------------------- -------------------------------------------------AVSERLEQAVRLESGELETPEP--RGLVRQS VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQAKTLQYKKKCSELEQQLVERSTELE--RQRLRDTEH---- ----------------------------------------------------------------------SHDLESALVR LEEEQQRSASLAQVNSMLREQLDQASSANQALSEDIRKVTTDWTRCRKELEQREAAWRREEESFN---SYITNEHSRLLL LWRQVVGVRRLVSEVKMSTERDLLHLGGELARASRAIQEADLGLSAGLRLAESRAEAALEKQAL---LQTQLEEQLRDKV LQEKDLAQLKVQSNLDKANLS-------ARVTELALTVERLQNQNLEKDQVNKVLTEKLEA---------LESLRLQEQA AVETEDGEG-------LQQTLRDLAQAVLSDVDSGVQLSGSERTADASDGSLRGLSGPRTPSPPRRASPGRG-------- ------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQIQDMRGRYEASQDLLGTLRKQLSDSEGERRSLEEQLQRL RD----KTDGATQAHEDAQREAQRLRSTIGLLS----------------------------REKDSLACSLQAAQQQAEE LQQER----------EKLQAAQEELRRQRDQLEEEREATAQDSARTRR--ELERSHRQLEQ-------LEVRRSGLAKEL VEVREALSCATLQRDVLEAEKAE-AEALSKAE-AGRVELELSMTKLRVEEASLRDSLSKLSALNESLAQDKLGLNRLVAQ -------------------------LEEEKAALLGRQRQVEQEASLAREEQERLEQLRLEQEVEQQGLEGSLRVAEQARE ALEDQLPTLRQERCRLQ---------------------EQLAQLSRQLSGREQELEQARRETQRQVEALDRASREKEALA RERAGLAVQLAAAEREGRTLSEEATR-----LRLEK--EALEGSLFEVRRQLAQLEARREQLEADGQALLLTKEALTG-- --ELVGLRQQVTTTEEKAALDKELMAQKLVQAEREAQ------ASLREQRVAHEEDLQR--LQQEKEAAWRELEAERAQL QSQLQREREELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES------------------------- --------------------------------------------EKQQALSLKESEKTALSEKLMGTQHSLAAISLEMER QKRDAQSRQEQDRS-------TVNALMSELRDLRAQLEEAADTHAQEVKRLQEQARNLERQRESSTR------------- ----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRQVREGQDGREAQRQEASELRRS LSEGVQEREALRRTNEELRAAVKKAESERISLKLANEDKEQKLALLTEARVAVGKEAEELRAGLQEVERSRLEARRELQE LRRQMK-------------------------------------------------------------------------- ------------------------------------------------------------------------MLDSENAR LGRELVELQGRLTLGERTEKEGRREALGLRQKLLKGEASMEA---VRQELQGAQRKLQEQEGEFRARE----------RG LLGSLEEARGAEKQQLDHARSLELKLEAARAEIAELGLRLSAAEGRGQGLEAELARVEAQ-RRADEVQLGGLRSALRRGL GLGRSPSPPP-----------------------------LPSTSFPTGSAPAGGSGEGLRSPSP-------LERSPGCEP PSPGPTTSP------------------------------------------------------------------ASPDL DPEAVRGALREFLQELRSTQRQ----RDELRAQMSALS-RQLAELEAERDNATSRVRQLQKAVAESEEARRG---VDARL SGAQAQL-ALQEESVRRSERERRAALDQVATLERSLQATESELRASQEKISKMKANEGR--------------------- ------------LENDKRRLKEVLDASEGRTIKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVASLQRQVADSEV KAGTLQLTVERLSGALVKVEESEGLLRDKVQGLTEALAQNSASLTSSQ----DKNLHLQKALTACEHDRQVLQERLEAAR QALSEARKQSSSLGEQVQTMRGELADLELQRAEAEGQLQQLQEVLRQRQE------------------------------ -------------------------------------------------------------------------------- -----------GEAAALHT-VQKLRDERRLLQERLDSLQGALAQREAEKREVERSALRLEKDRVALKRMLDKVEREKLRS HEDTVRLNAERGRLDRTLTGAELELAEAQRQIQLLEAQV----------------------------------------- -------------------------------------------------------------------------------- --VALEQDQSPG---RLEADEQRQLELQQE------VERLRSAQVRTERTLEARERAHRQRVRGLEEQ-VSTLKGQLHQE LRRTSASFPSASGP------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Felis_catus_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MSLGLEESVEAQLALETVIQTL ESSVLRAGRE-----------------------------------------KGLSEQDPAQDS-QLACLPARIREIITRN LSQPENQAPLP------AAEMASVLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN-------------------- -------------------------------------------------AVSERLEQAVRLESGEPETQEP--TGLVRQS VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQAKTLQYKKKCS-----ELEQRCP----TSPTQDTEH---- ----------------------------------------------------------------------SHDLESALIR LEEEQQRSSSLAQVNSMLREQLDQANSANQALSEDIRKVTSDWTRSRKELEQREAAWRREEESFN---TYISNEHSRLLL LWRQVVGLRRLVSEVKMSTERDLLQLGGELARTSRAIQEADLGLSAGLRLAESRAEAALEKQTL---LQAQLEEQLRDKV LQEKDLAQLQVQSNLDKANLS-------ARVTELALTVERLQNQNVEKDRVNKALTEKLEA---------LESLRLQEQA ALETEDGEG-------LQQTLRDLAQAVLSDMESGVQLSGSERTGDASDGSLRGLSGPRTPSPPRRSSPGRG-------- ------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSEGERRSLEEQLQRL RD----KTSGATQAHEDAQREAQRLRGAIDLLN----------------------------REKDSLARSLQAAQQQAEE LRQER----------EKLQAAQEELRRQRDRLEEEREDTARDSERTRR--ELERSHRQLEQ-------LEMKRSGLAKEL VEVREALSCATLQRDMLQAEKAEVAEALTKAE-AGRVELELSMTKLRVEEASLRDSLSKLSALNESLAQDKLGLNRLVAQ -------------------------LEEEKAALLGRQRQVEQEACLAREAQERLEHLRLEQEVEQQGLEGSLRVAEQARE ALEHQLPTLRQERCRLQ---------------------EQLAQLSRQLSGREQELEQARRETQRQVEALERAAREKEALA KERAGLAVQLAAAERESRTLSEEATR-----LRLEK--EALESSLFEVQRQLAQLEARREQLEADGQALLLAKETLTG-- --ELVGLRQQMTTTEEKVALDKELMAQKLVQAEREAQ------ASLREQRAAHEEDLQR--LQREKEAAWRELEAERAQL QGQMHREREELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES------------------------- --------------------------------------------EKQQALSLKESEKTALSEKLMGTQHSLAAVSLDLER HKRDAQSRQEQDRS-------TVNALTSELRDLRAQLEEAAAAHAQEAKRLQEQARNLDRQRESSVR------------- ----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKVRDSQDGREAQRQEASELRRS LGEGVKEREALRRSNEELRAAVKKAESERISLKLANEDREQKLVLLTEARVAAGREAEELRAGLQEVERSRLEARRELQE LRRQMK-------------------------------------------------------------------------- ------------------------------------------------------------------------VLDGENTR LGRELVELQGRLALGERAEKEGRREALGLRQKLLKGEASLEA---IRQELQGAQRKLQEQEVEFRARE----------RG LLGSLEEALCPGSPFADFCSSGCFILKEVLVYTARAGVGVFVWEMESPGEEVVVGRHPAPGPVAVDGAVGQLRCHLRRQE GLGPALS-----------------------------------------MPPPPGSGEGLSSPSP-------LERSPGSEP PSPGPATSP------------------------------------------------------------------ASPDL DPEAVRGALREFLQELRSAQRQ----RDELQAQTGVLS-RQLAEMEAERDSATSRARQLQKAVADGAEGEWRGACRPPRV SSGPASS-CVKEGGQQSSPRDDTQALLYHTMQLLGLALGS--DAAEQEKISKMKANEVK--------------------- ------------LESDKRRLKEVLDASESRTIKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVDSLQRQVADSEV KAGTLQLTVERLNGALAKMEESEGALRDKAQGLSEALAQSSANLTSTQ----DKNLHLQKALTACEHDRQVLQERLEAAR QALSEARKQSSSLSEQVQTMRGELADLEVQRAEAEGQLQQLQEVLRQRQE------------------------------ -------------------------------------------------------------------------------- -----------GEAAALHA-VQKLQEERRLLQERLDGLQRALAQLEAEKREVERSALRLEKDRVALKRMLDKVEREKLRS HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQLLEAQV----------------------------------------- -------------------------------------------------------------------------------- --VALEQDQSPA---RLEAAEQQQREVERE------VERLRSAQVQTERTLEARERAHRQRVRGLEEQ-VSTLKGQLQQE LRRSSASFPQTSGPPGE--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Myotis_lucifugus_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MSLGLGGSLEAQLALETVIQAL ESSVLGPGQE-----------------------------------------TGLSVQDPAQDC-QPAPLPALLREIVTGS FSKPESPALLS------ATEMASMLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN-------------------- -------------------------------------------------AVSERLEQAVRLESGELETQEP--RGLVRQS VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQAKILQYKKKGSELEQQLLERSTELE--QQRLRDTEH---- ----------------------------------------------------------------------SRDLESALIR LEEEQQRSSSLAQVNAMLREQLDQASSANQALREDIRKVTSDWSRSRKELEQREVAWRREEESFN---AYFSNEHSRLLL LWRQVVGVRRLVNEVKMSTERDLLQLGGELARTSRAVQEAGLGLSAGLQLAESRAEAALEKQAL---LQAQLEEQLRGKV LQEEGLAQLQMQSNLDKADFN-------ARMTELALTVERLQNQNLEKDRVNKALTEKLEA---------LEALQLQEQP ALDTEEGEG-------LQQTLRDLAQAVLSDMESGVQLSGSEHTADASEGSLRGLSGPRTPSPSRRSSPGRG-------- ------RSPRRGPSP-----ACSDSSVLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSEGERRALEDQLQRQ RD----KTDGATQAQEDAQREAQRLRSAIDLLN----------------------------REKDSLAHSLQAAQQQAEE LRQER----------EKLQVTQEELRRQRDQLEEEKEDTEQDRARARR--ELERSTRQLEQ-------LEVKRSGLAKEL VEVREALSCATLQRDMLQAEKAEVAEALTKAE-AGRMDLELAMTKLRAEEASLRDALSKLSALNESLAQDKLGLNHLVAQ -------------------------LEEEKAALLGQQRRVEQEATLAREEQERLEQLRLEQEVDRQGLEGSLRVAEQARE ALEHQVPTLRQERCRLQ---------------------EQLAQLSRQLSGREHELEQARRETQRQVEALERATREKEALA KERAGLAVQLAAAEREGRTLLEEATR-----LRLEK--EALESSLFEVQRQLAQLEARREQLEADGQALLLAKEALTG-- --ELAGLRQQMTMAEEKAALDKELMAQKLVQAEREAQ------ASLREQRAAHEEDVQR--LQREKEAAWRELEAERAQL QSQLQREREELLARL-------------EAEKEELSEEILPSEQSPQRPHVSADP------------------------- --------------------------------------------PQKEALSLKESEKTALTEKLVGTQHSLTAISLEMER QKRDAQSRQEQDRG-------TMNTLTSELRDLRAQLEEAAAAHAQEVKRLQEQARDLGRQRESCVR------------- ----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKVRESQDGREAQRQEAAELRRS LGEGAKEREALRRSNEELRAAVKKAESERISLKLANDDKEQKLALLEEARVAMGKEAGDLRAGLQEVERSRLEARRELQE LRRQVP-------------------------------------------------------------------------- ------------------------------------------------------------------------SAARHPPR GGQGLAQQTGNKLVGMCTETWASGHRVGRWPCWLSPSHLRPL---PLPQLQGAQRKLQEQEGEFRARE----------RG LVGNLEEARSAEKQQLDHARSLELKLEAARAEAAELGLRLSAAEGRGQGLEVELARVKAQ-RRAAEAQLGGLRSALRRVL GLGRAPSPALS-------------------------STGRQALGSLARCPPIRGSGDGPSSPSP-------LERSPGSEP PSPGPATSP------------------------------------------------------------------TSPDL DPEAVRGALRDFLQELRSTQRE----RDEFRAQTSALS-RQLVEMEAERDSATLEG----KAAAEGSIARRS---VDGRL SGAQAEL-ALQEDSVRRSERERRAALDQVAALERSLQATESELRASQEKISKMKANEVK--------------------- ------------LESDKRRLKEVLDASESRTIKLELQRRSLEGELQRSRLGLSDREAQAQALQ--ERVDSLQRQVADSEV KAGTLQLTVERLNGALAKVEESEGALRDKVKGLSEALAQNSASLTSSVGNL-KELINEREGLWASPAVWLTLQERLEAAR QALSEARKQSGALAEQVQTMRGEMADLELQRAEAEGQLQQLREVLRQRQE------------------------------ -------------------------------------------------------------------------------- -----------AEAAALHT-VQKLQDERRRLQERLGGLQRALAQLEAEKREVERSALRLEKDRVALKKTLDKVEREKLRS HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQLLEAQV----------------------------------------- -------------------------------------------------------------------------------- --VVLEQDQSPVGLEALEAEEQQQLELQQE------VERLRSAQVQTERTLEARERAHRQRVRGLEEQ-VSTLKGHLQQE LRRSSASFSPASGPPEK--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Monodelphis_domestica_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MSSRDEGPPVASPKLETVIQKL ESSLLT---SE---------------------------------------EEKDLTVQDPGQDGAPSRLPACIREIVTRN LSEPENPETVQ------TPEMASLLSLQEENHILQQELSRVEDLLAQSRAERDELAIKYN-------------------- -------------------------------------------------AISERLEQSLRLESG--EREPLGYGVLGQQT LELRRQLEEEQA----NYKRKLQAYQEGQQRQAQLVQKLQAKVLQYKKKCGDVEQQLLEKSTELEQQKLAQ----E---- -------------------------------------------------------------------EEHSQDLENALIR LEEEQQRSASLLQVNAMLREQLDQASVANQALTDDIRKVTSDWTRSRGELEQREAEWRREEESFN---AYFSN------- ----------------------------EHSRL-----------------------LLLWRQVV---G----------FR ---RLVSEMKTSTERD---------------------------------------LSQLGI-----------------EL ART-----------------------------------------SRTIHSASLG-------------------------- ------------------------------------------------------LSGSLR--LAESSSEAAMEKAALLRA QL----EEQ----------------------LRD----------------------------KVHDLIQLQVKSDLEKAE LSSRV----------HELTLLVEQLQKQNSEKDRANETLTQK---------VEALEAVRLQ-------EQAAMEAEEVEA LRT---------ESEVLQQTLRDLAQAVLSDT-DSGIQMGGLERTPETSDGSLR--GLSSLRTPSPLRRSSPRPS----G -------------------------SPRPSLSPAFSDSTLAL------------------VHSALHKRQMQVQVGSPATA EPCPVSKGKE-----------------------------------------KEDVGPSRGFPFCSWSG--DGGRS----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Takifugu_rubripes_CROCC_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------EKKLTVRGPSPDAPPACLPARVREIVTKN LSESRELPQS-----LAAGAMSSVMSLQEENRVLQGELARLEDLLAHSRADRDELAIKYS-------------------- -------------------------------------------------AISER-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------DEQSSNLEDALIR LEEEQQRSSSLSAVNAMLREQLEQAGIANEALSQDIRRLTTDWTKAREELEQKESDWRREEESFH---SYFSSEHSRLLM LWRQVVGFRRNVCELKNGTERDLSDMRNELARTCHSVQVSCSSLSSVLHSREGGAVLALEREKS---LRLQLEQQLRERV ---GEMMNFQTKADAEKSGLS-------LRLSDLLRESERLKGQIEERDTEIAVLMRKLKE-----------------QS VNDETDMQMMKTHTESLLDTLRDIAQVSCNTNMLAVRGRGLLQEGDSSSEADQENSGTPLLALFH------S-------- -----SSTRRSTSPSRSSSQALLTDSALCALRSAVTNKTLQLQDVRGRLISSQSSIQQLRKQLSESDLAKREAEQRIQSL QR----ERDAAQREKETTLKEKERLKEDRDVLAS----------------------------EKVSLEKVVQAAQGSSQL LEMES----------KKLQLIVASAQRERDHEREQKEAAVLERDRAKA--ETQRIQKQLEQ-------SESRLSSQRGEL SAVRETHQKGEVERQVLEGERAQLSEALARAE-SRNAELSLLLNKLQSEEAALRDSLAKVGSLNESLAQDKADLNTYILQ -------------------------LEEEKSVLQAQKREAQQQKLTIRDELR-LEQDRLELDAARITLQHSLQDVELSQV GVDAELQSLREEKVKLQ---------------------ERVTQLCSEVSSLGSELSLAKGEGQRSEVALEEAGRSRAELA RDKAALVVQLTASEKENTALSEELAA-----FRSER--ESLETSLFEMQQQLVQAESRREQLEAENQNLRLRSETAAV-- --ELRRLRSDGENVLAQAEREKQALTQTLNAAQLEAQ------QALHKAVSEHQEEVER--LVSEKEALRDSLLMEQESA LRKLRQEMEEPLHRA-------------EREREELQEELRSLQHDRDQSLLQAET------------------------- --------------------------------------------EKQQALSLKETEKAVLSDRVSCLQAELTAAALEAER MSREAALYKEQEQI-------RVAALNSELQALRSQLEDASSLHERELQSAREACTDLQSHTDVALK------------- ----------------ELDQC-------------RAALAANEETRDQ-LKRDVTDAERRQNQTVDTLETCRREVSELRRN LADITHEKDTLSHSNILLRETVRSAESERISVKRQHEEKEQKLSVLEESFASVQKEVTELRGCLREVERSRLEARRELQE LRRKLK-------------------------------------------------------------------------- ------------------------------------------------------------------------VLDGEKEQ KEREVAELQTRLLLEEQREEEKAKELFAVRHKLTEAETARDF---LKKELSMTQKRLVESESSWRSGE----------RE LSAQLQEARGCEKKLQDEAKNLALRTQAAQDSAAQSGLLLSETQGRLAATEAELIRAEAGKK-DLEFRLNSIQSALTRTL GIGASGRRGRG--------------------RSPGG-----SSTSPGTISRHQSISPLRTSLSPPKEIQVCTPDTTLNSG AASPERGEAP--------------------------------------------------------------LPLPQPEL DPDALRSDLRDFMQELRETQRE----RDDAKCRVGLLE-RELEEMLGDQDSTQSRLTHLQKAFQEYQEGKRG---LEERL STTQILL-QQQEEAVRRADRDRRAVTDRLRDLERALQVSETDKKNMQDQLNKQRAAEMR--------------------- ------------LDSERRRLREALEAAEARATRVELGRRSLEGELQRLKLSLGDRETESQNSQ--ERYDSLMKQLSEGEA RTSLLQRETERLSHSLLKSQEDESILKEKISSLRKSLQEAAASHSSHQS----RLAALQKMLTEVEHDKRLLQEQLEEAR VSAAEGKRSSASISERIQSLQGELSHSERRREELEAELRSTQELLQQRTA------------------------------ -------------------------------------------------------------------------------- -----------SLTEAQRS-AQSAQVERATVEERLRGLQRAVAMLETEKKDAERQAVRLEKDKNALRNTLDKVERQKLMT EESSMRLSAAKGRLDRSLNTAEQELQEAQQQILMLQTQL----------------------------------------- -------------------------------------------------------------------------------- -------ADLEQSHGLCESLVRQREEAQRE------AERLRSSFREAEQTLGARERAHRHRVKGLEEQ-VSTLKEQLLQE MKRRQPSLPSPLMPAGN--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Tetraodon_nigroviridis_CROCC_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------QRL EESVLS--------------------------------------------EEKKLTVRGPSPDGPPACLPARVREIVTKN LSESACVSG--------AGAMSSVMSLQEENRVLQGELARLEDLLAHSRADRDELAIKYG-------------------- -------------------------------------------------AISERLEQALRFDTADGDCDAAEPRSLAQQT LDLRRRLEEEQA----AYKRKLTAYQEGQQRQAQLVQKLQAKVLQYKKRCGDLEQILQEKTSELDKHLLS-----Q---- -------------------------------------------------------------------DEQSSNLEDALIR LEEEQQRSSSLSAVNAMLREQLEQAGVANEALSQDIRRLTADWTRAREELEQKESDWRREAESFH---TYFSSEHSRLLM LWRQVVGFRRNVCELKNGAER----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Gasterosteus_aculeatus_CROCC_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------AMSASGNSDSDSNKLESVIQRL EESVLS--------------------------------------------EEKRLTVRGASPDAPPTCLPARVREIVTKN LNETCEWPQSALPSCITSGAMSSVVSLQEENRVLQGELARLEDLLAHSRADRDELAIKYG-------------------- -------------------------------------------------AISERLEQALRFETGDGDHDSPESLGLVQQN VDLRRRLEEEQA----SYKRKLTAYQEGQQRQAQLVQKLQAKVLQYKKRCGDLEQMVQERSTELEKHRLS-----Q---- -------------------------------------------------------------------DESSSNLEDALIR LEEEQQRSSSLSAVNAMLREQLEQAGLANEALSQDIRRLTADWTKAREELEQKESDWRREEESFH---SYFSTEHSRLLM LWRQVVGFRRHVCELKSATERDLSDMRNELARASHSAQVSCAGLSAALQGREGGAALALEREKA---LRLQLEQQLRERV ---AETMTLQTRADSERSELN-------VRLTESAREAERLKGQIEERDREMVVLVRRLEE-----------------QS GHNESDMQAMRSHTETLLDTMRDIAQT-------------VLSDTESSSEADQDNSGVPLLALIRGFSSHRT-------- -----SSPRRSSSPSRPSSLAPPSEAALSALCSAVTNKTLHLQDVRGRLLSAQSAVQQLRKQLSEADSAKRDSEQRNQHL QR----ERDAAQREREITQRDKDRLKQERDTLAS----------------------------EKLSLEKNLQAAQSSTQI LQMDC----------EKLQLTVASTQRERAHDREEKEAANQERERAKA--ETQRIQKQWDQ-------SESRASAQRAEL SAVKETYQQAEIERQLLERENAQLTEALARAE-GSNAELSLLLNKLQSEEAALRDSLAKMGSMNEGLAQDKTQLNNYILQ -------------------------LEEDKARLQAQKREAEQEKLTIRDELVRLEQDRLELDSGHTTLHQSLQDAELSRA GTEAELQGLRAETFKLR---------------------ETVTQLCAEVTSLESELSLARGESQRNQVALEETGRGRAELV RDKAALVVQLTASERENAVLSEELTA-----FRSER--EQLETSLFEAQQQLVQVESRREQLETENQNLRVRCATAAA-- --DLRRERSDGENVVTQAERDKKLLTQTLNAAQLEAQ------QALRKAISDHQEEVER--LVSEKEVVRHSLLMEHEGT LRRLHMEAEDQLRRA-------------EREKEELLDELRSLQHDRDQSLLQAET------------------------- --------------------------------------------EKQQALSLKEAEKTVLSDRVSSLQAELSAAAVEAER MSREAAQYKEQEQI-------RIGSLTSELLELRSQLEDAASVHERELHSLQETCTDLQSRADVALK------------- ----------------ELDQC-------------RASHLAHEDSRDQ-LRRELLDCERRLNQCQDAAENSRREGTELRRN LADVSKERDTLGQSNTQLRVTLRSAETERISVKRQCEEKEQRLAVLEDNLSCNLKEVTDLRSCLREVERSRLEARRELQE LRRQLK-------------------------------------------------------------------------- ------------------------------------------------------------------------VLDGEKEQ MGREVAELRRRVSLEEQREEERGKELFTLKQKLTEAETARDS---LKKEISATQKRLAESESGWRGCE----------RN LTAQLQEARGCEKKLQDEAKNLALRAQAAQDSAAASSLQLSEAQGRLAATEAELTRAEAGRR-DLEYRLSSLQSALTRTL GIGAGGRGGRG--------------------RSPGGRSPGGSSTPPGPMSRHHSVSPLRSSLSPPKD------------- ----------------------------------------------------------------------------DPEL DPDTLRSDLRDFLQELREAQRE----RDDARCQLGGLR-RELEELSGGRESALIRLTHLENMLQECQEGKRG---VDERL TTTQVLL-QQQEEVVRRGDRERRALSDRVNDLERALQTSEMDRKHTQDQLNKQRATEVR--------------------- ------------LEAEKRRLREALEAAEARATRVELGRRSLEGELQRFKLSFGDREADSQASQ--GRHDALLKQVAEGDA CVSLLQRDVERLSQALLKAQDGESFLREKTSSLKKSLQEAEASHSSTQS----CLASVQKMLSVAEQDKRLLQERMEEAR GSLVEAKRNMVILTERVQSLQSELDQSELKREAVEAELNNAKEALRQRSA------------------------------ -------------------------------------------------------------------------------- -----------SAAEAQRS-AQSAQKERAAFEERLRGLQRAVAMLETEKKDAERQAVRLEKDKDALRNTLDKVERQKLKT EEGSMRLSAEKSRLDRSLNTTEQEVQEAQQQILILQTQL----------------------------------------- -------------------------------------------------------------------------------- -------AETEQSHGLCESLARQRDDAQRE------AERLKAGLRDAERTLGTRERAHRHRVKGLEEQ-VSTLKEQLQQE MKRRQPSLPSSLLSAGK--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Oryzias_latipes_CROCC_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------KAMSAAENSDSDPSKLESVIRRL EESVLS--------------------------------------------EEKRLTVRGPSPDDPPACLPARVREIVTKN LSDSSLMCVCA------AGEMSSLMSLQEENRVLQGELARLEDLLAHSRADRDELAIKYG-------------------- -------------------------------------------------AISERLEQALRSETGEGEADSQASRSLAQQN VELRRRLDEEQA----AYRRKLTAYQEGQQRQAQLVQKLQAKVLQYKKRCGDLEQKLQEKSSELEERSETSNGRHH---- -------------------------------------------------------------------EDSSSSLEEALLH LEEEQQRSSSLSAVNAMLREQLEQAGLANEALSRDIRRLTADWTKAREELEQKESDWRREEESFH---SYFSSEHGRLLT FWRQVVGFRRHVCEMKSSAERDLSDMRGELVRMSHLVQVSCAGLSAVLRSQEAGTALALEQERA---LRDQLEQQLRGQV ---KETMNLQSRADAERSELS-------LRLSDAAQENERLKSQMEERDREIDNLSRRLEE-----------------QS RSDETDSQLLRAHCNALLDTLKDIAQT-------------VLSDGESSSEADPDNSAVVLQALIR------D-------- -----SSPQRSSQTS--SSLSPLPEAALSALRSVVTNMMLQLQDVRGRLLSAQSSAQKFRKQLSEIDSAKRDADQRNQAL QR----DKDAALRERETAQREKEQLKTMSPTPS-----------------------------EKANLEKAVQALHSSNQM LQMDY----------EKLQLAVASAQRERDREREEKEAAIHDGERWKT--EIQRIQKQRDQ-------SESRASAQRGEL SAVLQTHQQGEVERQLLEQESAHLSEALARAA-STNKELSLHLSKLQYEDAALRDSLTKMGNLNEGLVQDKVDLNKYILQ -------------------------LEEEKAVLQAQKREAEQEKLSIRDELVRQEQNRLELESSRVTLQQSLQDTEFSRV GVEAELQNLRAERLKLQ---------------------EKVAQLCGEVASLDSELSLAKGEGQRSEMALEEAGRSRAELT KDKAALVVQLTASERENAMLAEELTA-----FRSER--ETLETSLFDAQQQLLQAESCREQLEAENQNLRVRCETATV-- --ELRRLRSDAENQLAQAERDKQALTQALSAAQLEAQ------QASRKATSEHQEEVER--LALEKEVVRHSLQMEHETA VRKLRQEVEDQLQKA-------------RREKEELQDGLRALQHERDQSLLQAET------------------------- --------------------------------------------EKQQALSLKEAEKTVLLEKVSGLQADLSALSLEAER TAREAAQYKEQEQI-------RVGALTSELQELRSQMEDAAAGHERDILSLNETCADLRSRADVALK------------- ----------------ELEQC-------------RASLSAAEENREQ-LRRDFLETERRLTQTQEASENHRREGAELRRS LCDVTRERDALSQSNAQLREALRSAETERISVKRQCEEKEQRLVVLEESLSSSQKEVAELRSCLREVERSRLEARRELQE LRRQLK-------------------------------------------------------------------------- ------------------------------------------------------------------------VLDADREQ KGRELAELQTRLSLEEQREEERGKEVFILKQKLAETQTARES---LKRELSMTQKRLVESESGWRSCE----------RE LTAQLQEARGCEKKLQDEAKNLSVRAQAAQESAAQCSLQLSEAQGRLTATEAELTRAEASKR-DLEFRLSSLQSALTRTL GIGASGRASRG--------------------RSPGG-----SSASPGSISRHHSISPLRPSLSPPKG------------- ------GGTP--------------------------------------------------------------LPPAQPEL DPDTLRSGLRDFLQELRDAHRQ----RDDAQCQLMTLQ-RELEEQKLERECAENRSTQLQNSLKECQEGKRG---LDDRL TSTQILL-QQQEDAVKRVDRERRALADRVRELERSLHTAEMEKKHTQEQLNKQRATEAR--------------------- ------------LEAERKRLREALEAAEARATRVELGRRSLEGELQRLKLGLGDREAESQASQ--ERHDCLLRQVAEGEA QVSLLQTEVDRLSQALLKAQEGEAALKQKVTTLSQSLQEAAADHSSTQT----RLTALQKTLSLVEQDKRLLQEKMDEAR TSVTEAKRSMFALTERVQSLQGELTQSELLREELEAELKNTQEALRQRSG------------------------------ -------------------------------------------------------------------------------- -----------SLAETQHS-IQKAQTERAAVEERLLALQRAVALLETEKKDAERQAARLEKDKDALRNTLDKVERQKLKC EEGSMRLSAEKTRLDRSLNAVEQELQEAQQQMLMLQTQL----------------------------------------- -------------------------------------------------------------------------------- -------AEMEQAHSGCEGLLRQRDEAQQE------AEKLRNSCKDLERTLSTRERAHRHRVKGLEEQQVSTLKEQLQQE MKRRQPPLPSTFTST----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Anopheles_gambiae_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MTTVLNGKDCAPSLG LRHSEGGGGGG---------GGSALADRSKKPFSRPFNKSRLQHEPSSTTTGGGVSGTGGP------------------- -----------------------------------------------PATTARMPSSTGSSSGPPS---AADTSALIRQN NELRHRLQEEANN----YRRRLETYKQAQNNQAALVSRLQAKVLQYKQRCSDLEQ-LPPSAGSCSGGGGGGGGGRYAGGS GSREPSPGSRHLHHAHHAPSPPPSAGGGGGGGPICTDVTGGPLSLPSACPVARERARSRSRSQSPCRKYSEGSHDEIRHQ LDEERRRCEKLLVENSCLRQQLEESHRTNEALTNDLQKLTNDWESLRDELLSKEDEWKEEEQAFN---DYYNNEHTRLLK MWREVVQVRRMFNEMTSTTKMELGRMHLELSGTVREVSGACSGVSVNLKQSSKFEEAQQMHIER---ENI----ELKSQL SELRLQFEAAKQEIGQRDQRLQ-------QMAQELKLLDDRYTQADSQAAQAHRMNDELER------------------- ----------------LQAALRDIAHAVVQDAETSASADMGGCGGGSAGEGGQHHLHLSQPIVSPGVAPRSPKRA----- -----SGGMAGTGGS-LRASQAFAEGTISAVQAALHKYQLAIHDLQVKLQTNNDALKATRKQYDSCEHARDTLSGKVSEL TE----KLDSANHQLSELYKERDSLQKTLDGLRS----------------------------DKHTVERGKAELNSIVDS LNTDY----------EKLQNVNSKLQKMYDALEEEKKMIELELQRVHK--DKDIQELNLRA-------EEERCSRLREET ITLREELNKLYLSRDLLEQQRIESDGLLNMLE-KQKLELEFELDRVTGERNELHSTLEKRTNSNEHQEQEIRQLKTTVAQ -------------------------LDEERGKLRAQSSDQSADLASLKKELISAEQARLDLDSEKLAISERLKCLEMEKD KIEAELSCVARERNDLS---------------------NQLATISRKKETIGEEVMRLRQRLEQSNEMNGRLNRSLEELV KESEEKTVTIEGHEKELQRLQEQLAS-----LRSEK--ESLEAVLFDTNTSLEEAEAKKDALERENQDLLIKQESHKA-- --LIARLNKDLENAERRAQDIKIQLTNAAANQEAEFL------QKLSNLRTFSEENIKK--LNDEKEQIRQSLEKRMQQS LQALESAKDAEIRQL-------------REQFETLQLHLDALNQQHEEVILRAEN------------------------- --------------------------------------------EKQQALLIAHRDKQAVIEKLEVTARELKNELENGDR LKREMAARQEKDRT-------TIGCLRDEVTKMRTKAEEARIRAEEEMNRLEVVAGSLREEKETLLK------------- ----------------DAEEL-------------KVQLRLSEDRCDA-LNHQLQDTHRKLKEAENSTDATRKDLTDTRRT LADSNIERDKYANSNKELRDHVKRVEEQRRQQARTIEDALAKISSLEETRNGLEQDKVRLQTILKETETNVTKLNQELSN AQTDIQ-------------------------------------------------------------------------- ------------------------------------------------------------------------KFQTDTTQ KDASEKELQARLANEGEEKERVLAELHQIKKQMADLEGTLCA---TRQELGRARCKANQDEHRFHQRE----------QE LCARNEEGRGREKRLEDQKHNLEVCLADATQQIQELKARLGGAEGRVRALDEQLVQLECQKK-EVENKLSSIGHTLRRIA GIQMDGSVSLP------------------------------YRLMSPSRRYSPARGGTGGRSEGGEHHHHDRHHHGHHHH HHGHETRSLS--------------------------------------------------------------GENVLIDV DPEMVRKGVRSLMQQIAHIERE----RDDFKVQLCTAR-KQLQEGSDAQLRLETKINKLQQHVRAVHEDKTN----LEAR LAQKTSALQSTEETLRQKSDELTALREKATQLEQSLTSTSEERTHLEERLDKCRQSGAR--------------------- ------------LESDKRHLQDELARTEARATKLDLQRVALEGDIQRLQMAMQEKDCTVRNQQ--ERLENQQRSLTQLED RCVALKSTVDQLKERLQAAAITETELRGEISGLQRHNADQSHTFALGQ----DKLKQLQKTLSGSENERRVLAERLDAAQ HTINELRRNQQASQDSTTRLQEQLAECEVQKSTLESQLRLAKWNQETSEQLAATGGNLGGGSGGA--------------- -------------------------------------------------------------------------------- -------GGNTSGDQELTRQLISSQRERNELRNKVEALNEKIRTLERDQQ---RPAGKYDRSEK---------KSGEYDS NRIES-------TTYSCGLDHAQLEQEGRELRMKVRRLET---------------------------------------- -------------------------------------------------------------------------------- --LLAEKEAELARSRAKLLESPSKASSLGGGSVGADVERYRSAQVQAERLLDAREQSHRQQVTRLENQ-IAMLREQLAQE AKRRQQYILRSSRAGREMQQLRQTIGDSLRNVA-------------------------------QDP-LDTSLLESEARR LDSAVS--MSLPPTTSATGRGRGEYDRSLSPTFR---------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Hydra_magnipapillata_CROCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MSFLDEKPPSDKSNDEDLPSLQSIIKRL EE--------------------------------------------------------------------NEIKIPTKET LTNSEIPISMRDVTKVMSNDVADAEKLIEENRLLYDDLLWSQNQLSLMKSEKSSLNSSKLPLYN---------------- -----------------------------------------------DYMRMQSPVNSSYNNESVRIQSPVSSFLSVENY ILQINQLKQKIEDDHSNYKRKLHAYQEGQEKQSELIQKLQSKVQQYKMRNNELEMIANDKSNELEELRDKLQVTIASAKE YEKRLMEFD----------------------------------------------------------EDRSNEMENYAVQ LEEEKQRNVNLQHANNMLHEQLEQATSANSHLSLETQKLSIELTKSCDELKHRDSEEEN----------YFTEEHRKLVN LWNSIDSFRSAFNIVKLETQKDLLQVKAEFSKSARTIQAASMELEKTQRGLSTVNQNTLLEEQA---QREKVESQLREKI RELIDLQATLNKMKDHYEIR----------LDEITNSLTESKARVDEQQKTIGLYKNKLKQLG------IEYSETTENWK NDSQVNIEAMREEIEVLQSTLYELANCILEDADSTSSSLDYLLSKVEAEIDTDNDIDPSSKVKDIVQSSSPLIH------ -------VKLRSKSPVRARSPAYIQSLVAGSQSAMKKRQLQLQEQKRQLDIAVMDKQSFKRQFDISSSKLQQLNTAYDEL KT----DHLSLQSKYNKSNEDCNKYRNQLQIIEK----------------------------EKQSFENMKNHLQNKVEE YEHKVN----------QLENQISYLKNNHENESEKKDSIMNEVSRLSN--ESQQLQKVIAD-------LECKQSMLKEEC VDLKEKLNRASLEKDVFLQENTHLQELLKSAQ-DERDDLENDVNKLKMDEVQLKDALVKLQTLNEALGEDKLNLGKIVLQ -------------------------VEAERDQIYKEKENLESEKLGLKEELLRIDKEKASLESERKGILEAINLNDATIE KLEEQLQEACFSKNKMN---------------------DTLNNVVREKEVSQYELVSLRLEVERLQNSLNRLLKEKEELT KENSLISVKLSGNLKEIQALTESNAL-----LKSEK--ETLESYLYELQHLVGKLEVRKEQLETSNHEVHLAKDTIAV-- --ELAHLKKENEIQTAKLNKENELLQQKLSLLERERD------LSLSRLKEQHEDQIHQ--LAMDKDKMLTAKKEEHLIV INELKEEMEDYQIKA-------------ERDRLALINEVASIQRERDDLLLQAEA------------------------- --------------------------------------------EKQAHLRAADSEKSLLVEKITKLKDDLDSANEELEI LKRDLEERAAREKD-------LLNDSAHEIEKCKENLEETVNLYEAKLKDLVDSHDKLLKNKEELYG------------- ----------------ELSNA-------------KFQLKILNENHEA-AQKECKELTNKVIDLNGKLDDASKHTLELKRS LKDAEVEKMLVLSGAEELREAFKQVESEKMTYKKNYEDSKKLASILDDTNVMQTRETDDLRHMISELETARQETRKEVQQ LQNRVR-------------------------------------------------------------------------- ------------------------------------------------------------------------LLDTECVK CKKDLNIAKDQLNKTNSLLEEERLDLINTKNKLRECETSKDA---IKAEMQALATKAREHNDEFGLRE----------KD LLMALEDARQTEVKVYDKMRQLENLLDVSNQEKSDLKLKLSSVEGRNLGLEDQLTKLEALKN-DLDSKLSNVYSALRRTL GIKPNQSINSIN---------------------------------LLVHLRPSQMSLRNVAHLTLGNRVYLQSSHDQSSE FDETPPSKNV--------------------------------------------------------------SFETSNEM DPEYVRNSLREFAQKFKDLEHE----RDEALINIGGLQ-RQLENLEMDRLDYENRLSVLQKSLQDTAEDKRG---ADGRL SSAQTAL-LLQEETIRRLERERKTAEEKFQILESTVAQLETEKRTLKEKYMKAHKHKLK--------------------- ------------YEQEAEAMRSQIDGAESRITRTDLKKKSLEGDIDRLRSQLHDAENEKHATK--QRLEILQRTCKDLEL KSSSLQLTVDRLNMSLSKSTDQEHLLQSKVTELSAIISEKQSVVVSLQ----DKLQQTERIIVSNEQEKQAAFEKVENLK KQLLENKKLNDLQNDKILNLRNEIANLESTRINLESELRQVQTLLQKNKV------------------------------ -------------------------------------------------------------------------------- -----------GDEELLNK-LEKFKEEKKNLQERLAQQQRLLAQGEQEKRDIEKNSVKVEKEKRALKATVEQLEKEKFLI DEELIQLKNDQTESDKIRSNYEQTINSLRIQLSQLQETL----------------------------------------- -------------------------------------------------------------------------------- -----EEKELQHNKKLASMSARHRDDLMKE------IERMKSSQQSLDRTYDARERAHKQRIRGLEDQ-INTLKDQFAKE IQQKQSFINRTTQKNEEIQEIRQKINSSINEVA-------------------------------RNADPRILDRESQKLD TTYDNYNDFSAVLTASTPYSNRMKVSPFIIDKYSSMTPTTDPGLMSSRIDLPITTEARNLSNTTFVSPIRKNLGKK---- -------------------------------------------------------------------------------- ------------------- >Homo_sapiens_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MSSASSEPGNGDASQQPLLGLDTVIQRL EDTILSPTASR---------------------------------------EDRALTVRGEGRQASPTPVPTRIREIVAGS LSEEPPQAGVQEPT-------ATVARVQEENELLQEELTRLGDLLAQASAERDELASRCR-------------------- --------------------------------------------------VVSEQ------------------------- --------------------------------------------------------LQARLETTEAQLRRSELEHS---- -----------------------------------------------------------------------VDLEEALGR LEAAEERSTGLCQVNALLREQLEHMKKANDALGRELAGMTGSVQRLQGELELRRWAQRQ-------TRSGGLGQPRDLLL LWRQAVVLGTDLAELRVATERGLADLQADTARTARRLHTACLNLDSNLRLSASSTASTLGQQ-------------LRDKA GEMLQLQGRWDAEKVALQAR----------LSEQTLLVEKLTEQNEQKAKTIAALRTDLQN------------------- -------------------------LVAQED----------ARCLELAGSSITELGEPRRPLRSPQRATSPHQG------ ------------ASPPHICSPATLDPALQAMRAAIERRWRREQELCLQLKSSQALVASLQEQLSESRRELWAAQKLQQER AREQAREREALRGQLEAQRLEVQQCRASCKLLGREKA----------------------------ALEMVVEELKGKADA ADAEK----------QGLEAEAAELQRSLLLQAERREELALRRERSCR--ALETSQGRLQQ-------LEEKVSGLREEL ASVREALSTAQLQRDVVESEREGLRSALARAE-CSNADLELLVRRLKSEGVEQRDSLAAMAALMEGLAQDKSALNHLALQ -------------------------LEQERDQLREQRKTLEQERARAGEQLAQAEQQLALERAERRGLQQACGRLEQRQE QLEGQAALLGREKAQLQ---------------------EQVGQVTCQKQALEEQLAQSLQDQEAQMGTLQQALQGKDALS EERAQLLAKQEALERQGRLAAEEAAD-----LRVE--RDSLESSLLEAQQLATKLQ---EQLEEEARSAGLARQALQ--- -VEMEQLQSDWEVQEMKLRQDTVRLQRQVAQQEREAQ------RALESQALAHREALAQ--LQREKETLSLTLAEEKEVA RCQLEQEKE-LVTKS-------------AAEREALKGEIQSLKQERDESLLQLEHKM----------------------- --------------------------------------------QQVMALSLKETERS-------LLSEELSRARRTLER VQQEAQSQQEQAQA-------TISATTEELKALQAQFEDAITAHQRETTALRESLQDLAAERGDVER------------- ----------------EAERL-------------RAQLTVAQEG--------LAALRQELQGVEESREGLHREAQEARRA LSDEAREKDVLLLFNSELRATICRAEQEKASFKRSKEEKEQKLLILEEAQAALQQEASALRAHLWELEQAGGDARQELRE LHRQVR-------------------------------------------------------------------------- ------------------------------------------------------------------------TLKAENQR RSGEA----------HELQAQCSQEVLELRRQAAKAEAKHEG---ARKEVLGLQRKLAEVEAAGEAHG----------QR LQEHLRESRGAEQTLRAELHSVTRKLQEASGVADALQARLDQACHRIHSLEQELAQAEGARQ-DAEAQLGRLCSTLRRGL GLQRQSPWASP------------------------------------EQPGSPTKGSDS--SQALPGQQGTSP--PARPH SPLRWPSPTP--------------------------------------------------------------GGRSSELM DVATVQDILRDFVQKLREAQRE----RDDSRIQMATLS-SRLSEAECRCARAQSRVGQLQKALAEAEEGQRRVEGALSSA RAAR----ALQKEALRRLELEH---------------LASVRAAGQEKR------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------RLQEQLETLR QALEESRRHSQGLAKQGKLLEEQLTNLEHRCQKAEVSLEPL--------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------RQMEQETLKR EEDVARLGAEKEQLDQSLNSLHQEVDGALRQNQQLQAQM----------------------------------------- -------------------------------------------------------------------------------- -----TEMEQAHTQRLQDLTAQHQRDLATE------AERLHGARPQATQALESQEWTHQQQVKVLEEQVASLKEQLDQEV QWRQQAHLGQAFQTGHAQRD------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Pan_troglodytes_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----SRSTGLCQVNALLREQLEHMKKANDALGRELAGMTGSVQRLQGELELRRWAQRQVLPQP--TRPGGLGQPRDLLL LWRQAVVLGTDLAELRVATERGLADLQADTARTARHLHTACLNLDSNLRLSASSTASTLGQQ-------------L-DKV GEMLQLQGRWDAEKVALQAR----------LSEQTLLVEKLTEQNEQKAKTVAALRTDLQNLVGGRDGG----------- ---GCVAGVC---HPCSGVSPATGSLVAQED----------ARCLELAGSSITELGEPRRPLRIPQRATSPHQG------ ------------ASPPHICSPAALDPALQAMRAAIERRWRREQELCLQLKSSQALVASLREQLSESRRELWAAQKLQQER AREQAREQEALRGQLEAQRLEVQQCRASCKLLGREKA----------------------------ALEMVVEELKGKADA ADAEK----------QGLEAEAAELQRSLLLQAERREELALRRERSCR--ALETSQGRLQQ-------LEEKVSGLREEL ASAREALSTAQLQRDVVESEREGLRSALARAE-CSNADLELLVRRLKSEGVEQRDSVAAMAALMEGLAQDKSALNHLALQ -------------------------LEQERDQLREQRKTLEQERARAGEQLAQAEQQLALERAERRGLQQACGRLEQQQE QLEGQAALLGREKARLQ---------------------ERVGQVTCQKQALEEQLAQSLQDQEAQMGTLQQALQGKDALS EERAQLLAKQEALERQGRLAAEEAAD-----LRVE--RDSLESSLLEAQQLATKLQ---EQLEEEARSAGLARQALQ--- -VEMEQLQSDWEVQEMKLWQDTVRLQRQVAQQEREAQ------RALESQASAHREALAQ--LQKEK-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Macaca_mulatta_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MSSASSEPGNGDASQKPLLGLDVVIQRL EDTILSPTASR---------------------------------------EDRALTMRGEGRRASPTPVPAHIREIVASS LSEEPPQAGVQEPT-------ATMARVQEENELLQEELTRLGDLLAQAGVERDELASRCR-------------------- --------------------------------------------------VVSEQ------------------------- --------------------------------------------------------LQARLETTEAQLRRSELEHS---- -----------------------------------------------------------------------VDLEEALGR LEVAEERSTGLCQVNALLREQLEHMKKANDALARELAGTTGSVQRLQGELELRRWAQRQ-------TRPGGLEKPRDLLL LWRQAGVLCG------TDGTRGLADLQADTAKTARRLHTACLNLDSNLRLSASSTASTLGQQ-------------LRDKV GEMLQLQVRWDTEKVALQAR----------LSEQTLLVEKLTEQNEQKARTIASLRTDLQS------------------- -------------------------LVAQED----------TQCLELS-WSITELGEPRRPLRSPQRATSPHQG------ ------------ASPPHTHSPATLDPVLQAVRAAIERRRRREQELCLQLESSQAVAAGLQEQLSECRQELWAAQKLQQER AREQAREQEALWGQLEAQRLEVQQCRASCKLLGREKA----------------------------ALEMVVEELKGKADA ADAEK----------QGLEAEATELQRSLLLQAERREELALQRERSCR--ALETSQGRLQQ-------LEEKVSGLREEL ASAREALSTAQLQRDVVESEREGLRSALARAE-CSNADLELLVRRLKSEGVEQRDSLAAMAALMEALAQDKSDLNHLTLQ -------------------------LEQERDQLREQQKTLEQEQVRAREQLAQAEQQLLLEQAECRGLQQACGRLEQQQE QLEGQAALLGREKAQLR---------------------DQVGQVTCQKQALEEQLAQSLQDQEAQMDTLQQALQDKDALS EERAQLLAKQEALERQGRLAAEEAAD-----LRYA--RQDGPRSLPSHTPSSPALL---RAPRGGPGLQ--SRGSMV--- -EPLELLLGPHGEREAGHRLRSPSFRNMNMLRPGEPL------HSAFCHSLFFEGGFIP--PPSLPNFLTSIPCP----- -------------------------------------------------------------------------------- ----------------------------------------------VQALSLKEAERS-------LLSEELSRARRVLER VQQEAQSQQEQAQA-------TISSTTEELKALQAQFEDAITAHQRETTALCDSLRDLSAERGDVER------------- ----------------EAERL-------------RAQLTMAQEG--------LAALRQELQSIEESREGLRREAQEARQA LSDEAREKDVLLLFNSELRATICRAEREKASFKRSKEEKEQKLLVLEEARAALQQEASALRARLRELEQERGDARQELQE LHRQVR-------------------------------------------------------------------------- ------------------------------------------------------------------------TLKAENQR RSGEA----------HELQVQCSQEVLELRRQAAKAEAKREG---ARKEVLGLQRKLAEVEAAGEAHG----------QR LQEHLQESRGAEQTLRAELHRVTRKLQEASGVADALQARLDQACHRIHSLEQELAQAEGARR-DAEAQLGRLCSTLRRGL GLWRQSPWVSP------------------------------------EQPGSPTKGSDG--SQALPGHQGASP--PARPH SPLRWPSPTP--------------------------------------------------------------GGRSSELV DVATVQDVLRDFVQKLREAQRE----RDDSRVQMATLS-SRLSEAECRCARAQSRVGQLQKALAEAEEGDLLGIGVLSTI RTSLXXXXXXXXXALRRLEAEH---------------LASVRAAGQEKR------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------RLQEQLDMLH QALDESRRHNQGLAKKGKLLEEQLTNLEHRCQEAEGSLEPL--------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------RQTEQETLKR EEDVVRLGAEKEQLDRSLNSLHKEVDGVRRQNHQLQAQM----------------------------------------- -------------------------------------------------------------------------------- -----VEMEQAHTQQLRDLAAQHQRDLATE------AERLHGDQSQATQALESQEWTHQQRVKMLEEQVAGLKEQLDQEV QRRQQAHLDQAFQTG----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Canis_familiaris_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------AHELGAAATPQCLWMAVLQRL EDTVLSPMASR---------------------------------------EDRALTVRGEGCRASPTPVPARIREIVAGS LGDEPHQG-VREPL-------GASARLQEENELLQQELCRLESLLAQAGAEHDELASRCH-------------------- --------------------------------------------------TASERVSG----------ARGAGPAEGRSG RPGGGVPAPLRRLAHLAPLSPEPSV-PSEAEPLPPRQMRTRWPGAELPQAAPCS-PLQARLETTEARLRRSELEHS---- -----------------------------------------------------------------------VDLEEALGR LEAAEQRSSGLAQVNSLLRQQLEHLRRANDGLAEELARTADGVLHLRSQLELREAQRGTGTQSQ----RPRDGGAQDLLL LWRRATALRAQLAELRAATDRGLADMRAEAARTARRLRTACLSLDCHLRLSARGEPGAPEQQAL---QASRLERQLRDKV REMLQLQGRWDAEKVALRAR----------LSEQTLLVEKLTEQSSKHESTIASLRADLQARESPRGGD----------- ---QRAAGVLEEEAASLRRVLRRIAEVAQAD----------AEGPLLATSGSAEAEEAGGQLRRPACSASPPPA------ ------------RSP---DTPDTPEVALQAVQAAIERRRRREQELRLQLESAEARAARLREQQSGDRQELQAARRLLHE- --------------LQAQAREAQQRPACGELLRRAPSR------------------------GSPGWGAGVAAGGKPWLR GQREK----------RALEPAVEEMRRKEAPSRRRMRSCRGAACCGRR--FLHLSRGRLEQ-------LEEKISGLRREL VSAQEALHLAQLQRDVVESEREGLRRALARAE-SSNTDLELLVTRLKSEGVEQRDTLARMAALTEGLAEDRSHLSHLVLQ -------------------------LEQERDQLREQQKALEQEQAGARERLARAEQQLEQVQGQAARLQQQRAQLEQQQY ---LKTIQNLSLPSSLM---------------------SHLSNTSCKKQALEEQLAQSLRDQEAQMDTLQRALQEKEALS EERTQLLAKQAALERQVQLTAAEAAD-----LRAE--RDSLESTLLDTQRLSGQLQAEREQLEGETQSLRLARQTLQ--- -VEMQQLKSAWEVQETKLQWDVGRLQRLVAQQEREAQ------LALESQALAHHEDLAR--LQRDKETLSLSLTEEKEVA ARRLEEEKK-LVAKN-------------AAKREALKEEIQTLKHERDESLLQLEHEM----------------------- --------------------------------------------Q--QALSLKEAERR-------LLEEELSRALQELEQ VRQEAQSRHE-------RAEAAVGATDAELKALQAQFEDAVATHQREAAALSDSLREVAAERSDTRR------------- ----------------EAERL-------------QAQLDEAREA--------LAVLRRELQGREESGEGLRREALEARRA LGDETREKDVLRRSNAELRAAIRRAEQDRASFQRAKEEGEQKLLVLEEARAAAQKEAWELRASLREVERAEADARRGLQE LGRQVN-------------------------------------------------------------------------- ------------------------------------------------------------------------MLETENRR KSQEVSQLQARGAQDAERQQQSQ------------------------REVLRLRQELAEVEAGAEAQK----------QQ LEERLRQSRGAERSLRAELRSVSGRLRQASGAAEGLQARLDEACGRLCGLEQELARAEAARR-DSEGQLRRLWSTLRCGL GLQGHGPPGSP------------------------------------KPPGLPGKGSDS--SPGRSPRHRASS--PSR-A GSPPRGPSPA--------------------------------------------------------------PGDHSSAV DVASVRDALRDFVQRLRDAQRE----RDDWHLQVLSLS-RQLREAESARAQAQSHAGQLQTALAEAEEAWRQAEGETRTA QAAR----ALQEEALHRLDAEH---------------LAS---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Felis_catus_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------VSLWTAVFQRL EDTVLSPMASR---------------------------------------EDRALTVRGEGWPALPTPVPARIREIVAGS LRDEPHQG-LQQPP-------AVSAGVQEENERLQEELSRLGELLAQADAEQDELAGRYH-------------------- --------------------------------------------------AVSARSFRGLRLL-RQDWAGDAPCGVLRAP GMSGSTPTPAVFRVLLAPAGSQEGC-RLWAGLVQLWEGSVPQPPCLLARWVTLTLQLQARLETTEARLRRSELEHS---- -----------------------------------------------------------------------ADLEEALGR LEAAEQRSTGLSQVNTLLREQLGHMKKANDRLAEELARTTDGVLHLRGQLELTEARRRAETQIR----RPRRGGSQDFLL LWRQVTALRVQLAELRTTAERALTDMRAEMARTAGRLQTACLALGSRLRLAASSAAGALEQR-------------LRDQV RETLQLQGRWDAEKVALQAR----------LSEQTLLVEKLTEQNSKKERTISSLKMDVQKLESRRSRGQRAADTLEDQV EALQRVLKSITEVLAHLG-PSRGTLKVAQED----------AGCPERACSGGPEAQEAQGQVRRPGSSASPHRG------ ------------VSPTRAHALDALHPALQAVHAAIERWRLLEQELRLQLGSSQAVAARLREQLSEAQRELQAARRLLQER AQEQVREPEDLLRELEAQSLEAQRCRESSELLQREKR----------------------------ALETAVEEMRGKAAC ADAEK----------QRLEAENTELHRSLLLWAEQKEELVQQGKRGRR--ELETSQGRLEQ-------LEEKVSGLKKEL VSAQEALNSARLQRDVLESEREGLHRALARAVGTGLPSLTPSHTRLSVP-----SPLVTLPPLLGARAWTRTPPCPHPRQ -------------------------LEQERERLRERQKALEQERAGALERLARAEQQLGPA-------QQACGRLEERLQ ---GREAAFERQRARLQ---------------------EQVGQVTCKKQALEEQLAQSLQDREAQRDTLQRTLQEKEALS EERAQLLAKQEALERQVRLTAEEAAE-----LRAE--RDSLERSLFETQQLVMQLQAQREQLEGQARSMRLARQALQ--- -VEMQQLRSAWEVQETKLQWDVGRLQRQVAQQERDLQ------LALESQALAHHEDLAR--LQREKESLSLSLTEEKEVA AHRLEQEKK-LVAKN-------------AAKREALKEEIQSLKHERDESLLQLENEM----------------------- --------------------------------------------Q--EALSLKEEERR-------LLREELFRAMQELGQ VRQEAQSQQK-------QAEATVSATAAELKALQARFEDAILAHQREAAALRDSLREMAAERSNAGR------------- ----------------EAEGL-------------RAQLDEAREA--------LAVLRGELQGSEESREGLRREALEARRA LGEEAREKAVLRSSNTELRAALRRAEQDKASFQRSKEEREQKVLVLEEARAAAQKEACELRASLREVQQARADACRELQE LGTQVN-------------------------------------------------------------------------- ------------------------------------------------------------------------VLRAENPR KGRESSEPGDRSGCDQGLQRQTR--WPQWRRRDGWLQRGRRSALMTLPQVLRLRRELEEAEAGAEARK----------QQ LEEGLCRSRGAERTLRAELHMVTGKLQQAGSVADGLQARLDEAGRRLHSLEGELARAEGARR-HAEAQLGRLWSTLCRGL GLRGPGPSGSP------------------------------------EWPGFPSTGSES--IQSAGPPTRSSS--PLRWP SPAPGDP--C--------------------------------------------------------------PDVE---- DVASVRDALTDFVQKLRVAQRE----RDDWHLQVVSLS-GRLSEAERERAQAQSRAARLQEALAEAEEGGMSVEGERRRA QAAR----ALQEEALRSLEEQH---------------RAGRRAASWEKRRLQ---------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Bos_taurus_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PAG-LREPL-------ASLGSGPEEHTLLQDELSRLEDLLAQAGAERDELAGRYH-------------------- --------------------------------------------------TVNERGGEMLGTRGQWEYKPQKPCSQIRQP KRGCRQLSPEDSPVVWASSRGFPATRPTWGLQAHLCQAARPAGLGSSRPGGSLPSQLQARLQATTAQLRRSELERS---- -----------------------------------------------------------------------MDLEDALGR LEAAEQRSTSLSQVNALLREQLEQLRKAHDRLAEELARTTGSVPRLWAELELREAQRRTHREAG----RARSGQPQD-TL LQRQVTALRGRLAELRAATEKGLADLRADVARMARRLHTACLNLSSNLRLTAGSEAAALEQQ-------------LRDKV REMLQLQGCWAAEKAALQAR----------LAEQTLLVEKLTEQNASKERAISSLRMDVQRLESQHGGGGPTAP------ ---EDSRAEVETLRLLLDSITQVQAQVAQAD----------AGSEELARSSGAEGEGAQGQRGSPLHAGNSLRA------ ------------ESP------ADPDSALWAVRQAIQRWRQREQELRQQLESSEARATGLQEQLSESQRELQASRSLLQEE RQ-------DLRGKLEAQSREAQWSRMTSELLGREKT----------------------------ALEETVEELRGEAAT SHAEK----------QTLEARNAELQRSLRQCTEQKEALERQGERGRR--ALESSQGRLEQ-------LEGTVSGLKTEL VSAQEALDSARLQRDILESEREGLHGALARAE-SSKADLELLVSRLKAEGVEQRDSLAKMAAVTEALAQDKGSLNHLVLQ -------------------------LEQERDELRAQQQTLAQGQAGTREQLAQAERQVELLRAERRGLQRACGRLEERLE RLEGQATRLRRERAQLQ---------------------EQVGQVTCKKQALEKQLAQSLQDQEAQMAALQRALQEKEALS EERVQLLAKQEALEKQGQLMAEEAAD-----LRAE--RDALESSLFEAQQLASQLQARQEQLEGEARGARLARQALQGAA PMKLEQLQSVQEAQET-------RLRRQAAQQERDAQ------LALESRALAHREDLAR--LQREKETLSLSLMEEKEAA ARRLKQEKE-LVAKN-------------ATRRAALKEEIQSLRRERDESLLQLQHEK----------------------- --------------------------------------------Q--QSPQPAQERPTPVTQALLLRDAELSRLRGELQL VRQEAQGQQE-------QAEATISTVASELKALQAQFEDAISAHQTEARALRETLRALVAQRSSTGR------------- ----------------EAETL-------------RAQLDEAHEA--------LAALHRELQGSEETQEGLQKEARDARRA LADAAREKDALRDSNTELRATLRRAEQEKASFKRSTEEREQKVLVLEEAWASAQKQAGELRASLREAERAAVDTQQQLQE LRRQVT-------------------------------------------------------------------------- ------------------------------------------------------------------------TLEAENQR KSRELVRLQTRGAQEPSRQEALALQTLVAEAKAARED--------SQWEVRRLRRMLAEVEAQAKTRE----------KH LERQLCESRGSERALWAELRGVARKLLQADGVADSLQARPDRACGRAHGLKQEPARAEGTQR-ETEDQRGQLWSMLHPSV GLHGWSPVASP------------------------------------EPAGPPSRGQCP--PRPPSHPPGAPQ--PPRGS PSLPEKG------------------------------------------------------------------------- ARASMRDAQRDLTQKLWDAQWEGAGRRLSLGLQAFCLSPLALGEAESEPTWALSRIGQLQKALAVAEKGWHQVEDKLSSA QAMW----ALQEEALPR--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Equus_caballus_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------AERDELASRHH-------------------- --------------------------------------------------AVSER------------------------- -----------------------------------------------------------------------DLEHS---- -----------------------------------------------------------------------VDLEEALGR LEAAEQRSTGLSQVNALLREQLEHLKKANDTLAEELARTTGSVLHLRGELELREAQRRTERQNSN--WYLSKWEPRDFLL MWRQVTALRAHLAELRAATERGLADMRADTARTARRLHRACLNLDSHLRLSASRAADALEQRAL---QGTRLEQQLRDKV REMLQLQGRWDTEKVALQARWVPGSAGPPGLSEQMLLVEKLTEQNSKKERTISSLKMDVQKLVRGAGR------------ ---QRPCRGVSVRLAEGS-ALAAGVPAWRRP----------AG------SGRPEGPSGD-RLRSPPRTASPYRG------ ------------VSPPRTRSLAASDPALRAVQAAIQRWRLKEQELRLQLESSQAVVAGLREQLSESQQELRASRRLLQER AQEQAREYEDLLGKLEAQSREAQHCRATSELLGREKK----------------------------ALESVVEELRGKANT WDVER----------QRLETKNAELQRSLLLWAGQKEELVQRGQRGRR--ELETSQGRLEQ-------LEEKVSWLKKEL LSAREALNTAQLQRDVLESEREGLRGALARAE-SGSADLELLVTRLKSEGVEQRDSLAKMAALMEGLAQDKGTLNHLVLQ -------------------------LEQERDQLREQQKALEQERAGAQEQLAQAEQQLELVRAERRGLQQACGRLEEQLE QLEGRAAQLRRERAQLQ---------------------EELGQVTCKKQALEEQLAQSLQDREAQMATLQRTLKEKEALS EERTQLLAQQEALERQGRLTAEEAAD-----LRAE--RDSLESSLLEAQQLAMQLQAQQEQLEGEAQSARLARQALQ--- -VEMEQLKSTWEVQETKLQWDVGRLQRQVAQQERDMQ------LALESQALAHREDLAR--LQREKETLSLSLTEEKEVA ARRLEQEKE-LLAKS-------------AAKREVLKEEIQSLKHERDESLLQLEHEM----------------------- --------------------------------------------Q--QALSLKEAERS-------LLREELSRATWELER LQQEAQSREE-------QAEATISATTAELKALQAQFEDAISAHQTEAAALSKSLREMAAERSNAGR------------- ----------------EAERL-------------RAQLEEAQEG--------LAALRQELQGSEESREGLRREALEARQA LGDETREKDVLQLSNAELRAAVRRAEQEKASFKRSKDEKEQKVLVLEEAQAAAQKQAGELRASLREAEQARGEARRELQE LCRQVK-------------------------------------------------------------------------- ------------------------------------------------------------------------TLEAENRR RSQEVSRLQARVAQDAQRQQQSRQEALELQRQVAEGEAAQKEPLRSLLQVLRLQRKLAEVEAGGEARE----------RQ LEERLHESRGTEQSLRAELRGVTGQLQQAGGVADSLRTRLDEACRRVHSLEQQLAHTEGARQ-DAESQLGRLWSTLRRGL GLGARSPSTSP------------------------------------ERPGSPTKGQCS--DGSEGHSGRHSA--SPPGP ARPSHGPRLH--------------------------------------------------------------PEIHGPEV DVASVRDTLRDFVQ-LRDAQRE----RDNWRLQVASLS-SRLSEAESERARAQSRMRQLQKALAEAEEGWRQAEGETSRA RAAQ----ALQEEALQRLQTE----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Loxodonta_africana_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------ETTEARLRRSELEHS---- -----------------------------------------------------------------------VDLEEALGR LEAAEQRSTGLAQVNTLLREQLEHMKKANDALAEELARTAGGVLRLRGELGRREERRQPNMESNGFNCVYWTGESQNLLP LWRQATALQAYLAELRAATERGLADMRAEAARTARRLHTACLNLDPNLRLSAHSAAGAQEQQ-------------LRDKV QEMLALQGCWDAEKVALQAR----------LSEQTQLVERLTEENTEKEGTIRALTVEVQGLESRRGRG----------- ---QPSMDDLRDQVDALRQVLNSITKVPLPSPALQGLRVFRKKGTELVQSGSTEGYEMLGQPKRPLHTTYPGPGG----- ------------LSPPQAQSPAALDPALRAVRVAIERRQQREQELRWKLEASQAVAAGLREQLSECRQELLASK----GP LWEQAWEHEALLGELEAHRWEAQGCRASEERLGREKA----------------------------ALEAVVEELRGQVDI SAVER----------CRLEAENVELQRSLLLCAEQGNELAQQEQRSRR--ELDTSQGHLEQ-------LEEKVSGLKKEL VLAREALNATQLQRDVLEGENEGLRSALARAE-SSNADRELLVTRLKSEGVEQRDSLANMATLMEGLAQDKGTLNHLILQ Q------------------------LEQERDRLREQQRVLEQEQARSLEQLARAEQQLAREQAERRSLPEGSVQLAR-EA QLQSRWPVR-HLWAGLQ---------------------CQLPQVTCGKQALEEQLAQSLQDREAQMDTLQRAMQEKEALS EERAQLLAKQEALERHSRLMAKETAD-----LRVE--RDSLESSLFEARQLVSKLQTQQEQLEGEAQSARLMRQALQ--- -VDMEQLKSTGEVRETKLQWDLEQLRRQVAQQERDSQ------LALESQAVAHREDLARLQREKRPGKVYKMLSKCRMAG TEAQRGREL-KGCLC-------------RFLPPPHSSNVQRGAASSRAPVSFTCTPS----------------------- --------------------------------------------CHLQALSLKEAERN-------LLREELSTATQELER ARQEAQGQQERAKA-------TISTVTEELRVLQAQFTDAISTHQKESAALSTSLREVAAERSSMGR------------- ----------------EAERL-------------RAQLDVAQEG--------LAVLRRELQGVEESCEGLRREALEARRA LADEAREKDVLQLSNTELRASIRTAEQEKASFKRSKEEHEQKVLILEEAHAAARKEAGELRAGLREVERARADARRELQG LRRQVK-------------------------------------------------------------------------- ------------------------------------------------------------------------ALEAESQR KGQEVGELQARAARDTQLQEQGQQEALELQRRAAELEVAYEG---ARKEVLGLQRKLAAAEASGEAQE----------KQ LTAQLRDSRAAEQTLQAEVRSVARKLRLADGTAEGLRARLDSACSRIRGLEQELAQAEGARR-DVETQLDRLCSTLRRSL GLQGQSPVASP------------------------------------ERSSSPTKGSDG--SQAQTWRQSTSP--PAESC SQLRWPS--P--------------------------------------------------------------GARDVEVL DVVCVRNALRDFVQKLWDAQRE----RDDARCQAVSLS-SQLSEAESARARAQSRTAQLQEALAEAEEGQRRAEAEVSSV QAAR----ALQEEALSRLEMEH---------------LASTRAADKERCRLQVEAQLEWAS------------------- ------------ELAGTRRRYLELPVAELPRTSAELRATSVKGNAQEELGSRGAGAAGLLRRGDGLQSVISQSAVDER-- RAALTVTRYG------AAREESNWSPCSPRREGRGLCFPLAASALQLILIR-KPLLFYEKMCTSGKWSFSNLQEQLDALH QALDESRRHSQGLAATGRLLEGQLAGLERRCQEAEGTLEPLRQVLRRRQR------------------------------ -------------------------------------------------------------------------------- -----------GEQAAAAAEKRVLREQTAALRTERARLQGQLAALRARLAQVPSAGPGVGRTRNPGRGSQRRTERETMRR EGTAARLEAKKEQLDQSLSALHQEVNGALRQNQQLQAQM----------------------------------------- -------------------------------------------------------------------------------- -----AELEQAHTQRLQELAAQHQQDLAAE------AEQLHGAQLQAAQALEFRERTHQQRVKVLEQQVASLREQLDQEE QRRRQSPQAAGSAPPSQ--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Dasypus_novemcinctus_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------VLQRL ETTVLSPTASR---------------------------------------EDRALTVRGDGRGASPTPVPARIREIVAGS LSEEPPQG-VREPP-------GAAARVREENTLLQEELSRLEDLLAQTGAERDELASKYH-------------------- --------------------------------------------------AVSERSRS-----------CSKRPPGSERV KLGRGSVVQMGKLRQESDDARYARAPSLCQPFLERNGFAAGLGAGGHGLRAARCGQLQARLGSTGARLRRSELEHS---- -----------------------------------------------------------------------ADLEEALGR LEAAEQRSTGLAQVNALLREQLQHMKTANDRLAEELARTTGSVLRLQGQLERGQAWRQAEREFIYFFNIQCIFVKMSFYL SGLGFIRLLVSLIVFITLDDILVLGATLKKANCGSKSTGEIFSPSAALQNSRQSVPSLPAVFGL---AMRVQLLEYHLHV AQRAVGAGRKHIPRGASSAR-------CHWLNEGVGAPQMWNKGRGSDNGEVAAQEARCHG------------------- --AQQAVDSLKDKVGSLQHALSSVSKVAQAD----------TEHPQPAWSSSAEGEEVRGWPRSPLPTATPPPRG----- ------------RSPPRACSPAAPDQALQAVQTALERRRQQEQELCLRLESSQEAAAGLREQLSESRRELRASWR----- ------ECERLRGQLEARR-----CGAARELRDREKE----------------------------ALETALEQLRAKADA ADAEK----------HRLEAANAELRRSLRGRTEQQEELARRGARSQR--ELEASQGRLEQ-------LEDKVSGLKKEL VAAREALSAAQLRQDVLEGEGEALRGALARAE-SSNTALELLVTRLKSEGVAQRDSLAKMAALMEGLAQDKGTLNHLVLQ -------------------------LEQERDRLQERQKALEQAGAGAREQLAGVEQQLERERAEKQGLQQACGRLEEQQG QLEGQAAQLRHERAQLQ---------------------EQVDQVFGTRSGGESPLSCLRCPAEAEVSSVSRRAGQSEACK HT-GGLAPVCPPLSRNGMAASERYGP-----RRAA--RDSLESSLFEARQLATQLQAQQAQLEAEAQGARRAWRDLQ--- -VEMEQLKSTWEVQGTKLRWELEQSQRQVARLERDSQ------LALDSQALAHREDLAQ--LQREKETLTVALAEEKEAA ACRLEQERE-LVAKT-------------AGEREALRDEVRSLKQEWDESLLQLEQEL----------------------- --------------------------------------------Q--QALSLKEAERS-------LLSQELSGATQQLEQ AGQEARSRQEQ-------AEATVSAMAEELRALQAQFEEAISTHQREAATLNGSLREAAAECSSVGR------------- ----------------EAEQL-------------RAQLDVAQEG--------LAALRRELQSSEERGKGLRGEVLEARRA LGDEAREKDVLQRSNAELRAAVRQAEQDRASFKRSKEEKEQKLLVLEEARAAAQKEAGELRASLREAEKARADVHRDLQE LRRQVR-------------------------------------------------------------------------- ------------------------------------------------------------------------TLEAENQR KGQEVSTLQAQRAQDAERRRQSQREALELQRAGAEAEAAR-------KEVLQLQRKLAEAEAG----------------- AEGHLRESRAAERALRAE--------------ADGLRARLDVACASVCSLEQELARAEGARR-DAEAQLCRLGSVLRRGL ALGGRSTPASP------------------------------------ARPGSPTKALQPPCPAGSDGLQSASP--PAGPR SPLRGSSPAP--------------------------------------------------------------RDHSAEAV DVAAVQGALTDLVQRLRGAHWE----RDDARLQVVGLS-ARLGEAESGRARALSHAGQLQRALAEAEEGQRRAEAELSSA RAAG----TLQEEQLRAGAAEKRHLQKVVAYLHFSCQCSSQPSASWEEARSPAYCDDLKLY------------------- ------------GSQKKTPEPLLASSEAPPTLLCQRAVLQGQNEPQSRILEEESSEPRPLPRHVSGIAKKGAQPRDGAGC SREPTKRSSG------QLAKKAGSRPALPSLGVRGSARVVVTIQNTLAPAC-FPPLCIPLTARQGDPVSPLPQEQLEALR QALEDSRRHGQGLGARGRQLEAQLADLGRRCQEADGALEPLRQVLRRRQR------------------------------ -------------------------------------------------------------------------------- -----------SDQAAERRVLREETAALRTERTRLQGELAALRARLAQVRPVPVRAQRDTVPG--CRRQVFRTESETLRR EGDTARLGAKKEQLDQSLSSLRQEVDGALRQSQQLQAQV----------------------------------------- -------------------------------------------------------------------------------- -----AELEQAH-RRRRELATQHQHDLAAE------AEQPPRAQLQAAQALASPGQTHQRRVKVLEEQVASLKEQLDQEA QQ------------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Myotis_lucifugus_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------VFQRL EDTVLSPTASK---------------------------------------EDRALTVRGEGWQASPTPLPARIREIVASS LGEEPPQG-VREPP-------GASAQVQEESELLQGELSRLEDLLAQVGAERDELASRYH-------------------- --------------------------------------------------MVSERLRN--------------SCDPWPGS SILCAFQGVRQAAARGRFGYKVRGV-GSGGNPPPPCPQGLSSLPQHPRLCSESAHLLQAQLQTTEARLRRSELEHS---- -----------------------------------------------------------------------VDLEEALGR LEAAEQRSTGLSQVNTLLREQLEHMKKANDALAEELARTTGSVLHLRGELELREAQRWTERQTRR---SHLGVQPQDFLL LWRQVTALRTHVAELRSASERSLTDMQAEAARTARRLHTACLNLNSNLQLSASSSAGALERQAL---QGAWLEQQLRDKV REMLQLQGRWDTEKVALQAR----------LSEQKLLVEKLTEQNSEKERTISSLRMDVQRLESWRSGG----------- ---QLAADNLKEEVKSLRRVLNIITEVAQAD----------SRCPELAQSSSTDREKAQRPLRSPPRTSSLHWG------ ------------ASPPRAHSRASPDPALRAVQAAIERRRQQEQELRLQLKSSQAVTARLREQLSERQRELRASRRLLQER EQER----GDLLDRLEAQSQKAQHFRAASELLGREKK----------------------------ALELEMEELRGKMDV WDMDK----------QKREAEIAELQRSLLLWTQQKEELEQQGERGRR--ELQTSQGRLEQ-------LEEKVSGLKKEL VSAREALNAARLQRDVLESEREALHGTLARNA-----DLELLVTRLKSEGVQQRDSLAKMATLMEGLAKDKGSLTHQVLQ SMEAQVCGAWAWRHRCVGHPPPPRQLQQEGDQLREQEQVLRQERADARERLALAEQQLEQLEG----------------- ----QADRLQRERAQLQ---------------------EQVGQVTCKKQALEEQLAQSLRDQEAQMDTLRTALQEKEALL EERVQLLAKQEALERQGRLTAEEAAD-----LRYPGAYGQGVCAWPCLREAAVWQGAAEETWRASGRRKVLGRESSL--- -VELEQLKGAWEVQETKLEWDIGQLRRQMAQQEREAQ------LALESQALAHCEDLAR--LQREKETLSLSLTEEKKVA ACRLEQEKE-LVAKS-------------AAKREALKEEIQSLKHERDESLLQLEHEM----------------------- --------------------------------------------Q--QCDTVKYSLSS-------EWKDKHWVCAHSCST LRFLRRRKKRXRKAQGTRNRATVRATAAELKALQAQFEEAISAHERETSALNHSLRKMAAERSNAGR------------- ----------------EAEQL-------------WAQLGEAQEG--------LAVLRRELQGSEDSLEGLRREVVDAHRA LGDEALEKDMLQRSNAELQAAVCKAEQEKASFQRAKEEKEQKVLVLEEARAAAQKEAGKLRASLQEAERAQLDTCRELRE LRSQVK-------------------------------------------------------------------------- ------------------------------------------------------------------------MLETENQR KSQEVCQLQAQCAQDSQRQQQSW------------------------REALELQRQAAEVDAAREDAQKEVLRLQQKLAE VKERLCESHRAEQSLRAELHGATMKLQQASSVTDSLQARLDRACHRVHSLEQELARAEGARR-DAQGQLSRLWSTLCCEL GLRAQGPSASP------------------------------------KRPGSPTKGLDG--SQGHSGRHSASP--PAR-S RSPLRWPSPA--------------------------------------------------------------PGQQGPDM DVASVQDALRDFMQKLRDAQQE----RDNWRAQVRHLS-SWLREVERERARAQSHVGQLKTALAQAEEGWRQAEREAGSA QATR----ALQKEVLQRLEREH---------------LASVRTAGQEKRRLQVGTPHPRAG------------------- ------------RGK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Strongylocentrotus_purpuratus_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------MLREQLDQATEANRSLNHEIDQLSNEVKRSQDDLDNRETEWRDEEKSFN---EYFNSEHSRLLV LWRQIVAFRRNFAEMKSSTERDLTQMRSDVTRTSRNTQSACQNLQSASQGSETGAVMALEREKG---EKMQLESQMREKL ---KDMLDMQAKFDAEKGDLT-------TRINELTIANERYKIQVAEKENQLRQRSASAAGGDHFDSAQSEASQEAYMLP GADGGSLRAVQEECEALHMALRDIAQAVIQDADASAADMSEFAAGQEGDVTLDVSLASPYAKSTPLRPLSPTRYNRHRSP SPRRPVTPSRRTASPSRARSPGFPDSTYSAVQAALQKRQLQVQELKARLNSTRDQASTLKKNLEGSENERRQTERAVDAH RD----NLSVSQRQLEEIKRDRDRLRNSLEATG----------------------------SEKSGLENLRQSLNAQIES LNVEN----------ERLQAANSDLQRQRDHLEDEREDREKDSIRQKK--EIERSHKLLEQ-------MEGKNSNLKEDI VTLKEALNKAVLEKDVLEQEKAEISESLARLE-VQRAELEVELNRLRTEEAGLRDSLLKMQALNEGLGQDKIELNKIIMQ -------------------------LEAEKNRLIEDKDNIHHERAAIRDELMRVESEKVDTETEKMGLNQSLSLMEDNRT RLEEEMSLLNREKGELG---------------------DNLSQLSRQKNSLAEELLQTRRDVERQIEAVTRIAKEKEELT KEKAELIVQLTASERENRAQAEVIAA-----MNTDK--ESLERTLYEYQQSLAKLEAKRTQLESELQEQGVSKEGVTV-- --ELARQRKEMEIEMTRYQKDLELLNQRMVQQERDTQ------LALKQRQQAHDEDVER--LNRERESLKLAMEAEKEDL VRKTNQEREELNGRY-------------MQEKEELTEDLMGLQRERDESLLLAEN------------------------- --------------------------------------------DKQQSLSLAQTERNQLVEKLNSSQRDMANASMEMDR IKREAFTRAETDKE-------AIRDVQDELKELRARFEEGT---NVRERQAKDLS-NQIKDLQKVKE------------- ------------ALLREVNEL-------------KTQLKMAEESRDG-VRRELIEAHRKIREGDEGREIQRKENMELKRQ MNDEVREKDAINRANEELRQKVKKVETDRIQLNRNVEERTQKIAVLEESKTAIQKEAGDLRASLREVEKSRLEARRELQE LRRQVK-------------------------------------------------------------------------- ------------------------------------------------------------------------TLDTDKAK LTKDIHDLQNRVARDDEKEEENRKEIYALKQKVMETEAERES---ARKDAQNLTRRFGDLEEELRLKE----------KD YAMSVDEARSAERRISERLRTTENALDETKADLGDLKLKLSAAEGRVNGLESQLAQVEGAKQ-EVEFKLGSLHSTLRRTL GIGAGGMGSSLSLASSTSPGPRSSLRDRSPSPVRARRTRSPVKGFDNTFAS-TADGFGTPIPRTGSPELQDRSASPLPTR STSPTRMEQ------------------------------------------------------------------LVADI DPETVRIALKDFSQQLKDTERE----RDEAFCRIRLIT-QELAENEAARHRVDQRLQQFQKSLTEAEEGKRG---ADGRL SSAQTAL-MLQEETIRRSERDRKGMQEKINTLERSLQSAEAEKRNQSDRIAKMNQGSQR--------------------- ------------MEGDKRSLRETLEASENRCTQLELKRRALEGDLQRSHLSMNDKETESQVLQ--DRIEALMRQIQDLES KNTSLQLTVDRLSSSLARSEEGEHTLKDQLQSLSLSLNDTAMESTQKQ----EQLHHLQQAVANSEKDRRVLQERLDAAR HGASDAKKQNHQLIERVQQGQNDLAECELRRAELEQQVRSSQQLVKQHQE------------------------------ -------------------------------------------------------------------------------- -----------SEETTMTQ-IQRFQAEKRSLKEHVTTLQKAYSNLETEKREVQRSAGRLEKDKTALKKTLDKVEREKMRH EEAVMRATSEKGALDQSLTSLDQENIELQRQTQALQATL----------------------------------------- -------------------------------------------------------------------------------- --AETEQQHAQRLIELTTRHRQ---ETEIE------TERLRTAQLQAERTLEARERAHRQRVKGLEEQ-NSTLKDQMHHE VRKRQQYISMSSKTNDEIQDLRNMLSDSLHSVA-------------------------------RDPTLDPVLLEHETRK LDESMGYSSSLRRSARGASPPTS-LSPRLAKDRNRSISPVRLGKPASTSTPGMDSKLRSSSGRTRSARGLSPSSLRGSLR K------------------------------------------------------------------------------- ------------------- >Capitella_teleta_CROCC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------MSTDSTDYSGSRSYKRRSGGGGWERTSRKVENLAHSLKDTN------------------- --RNLKAVDKMLLDYKDASEQQ---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------NSVIDKLQGDVSRSRHRIRDEKARIRGSSLRGCSEEDLSRDSRRRSRMPTSPLRNY DR--------------------------------------------------------------------AASDHEFADD WQPTR-----------------NSVRFYDDMDTPPRLHRLHQSVRDVS-----------------------------SEQ LRLEDDLQQEILRRHRIETDHNKTLAALLEQTKQADPALNSVEQRLQSIQDELRSERTFLRRKQDEVGKVSQELKQQPAN --------------------------------------VVYDGRVNAVENEAQLRARLTQVETQKTAMESELERTKQRLE QVDGNKSTLITEVNDMR---------------------RQLSRVEHERDQLGLQLEQRERDLKAQLKTRSLDEQQDGLRE QEIKRLKQDLEEARSQLTKSASVVGD------------------YGELRRELDKSERLRSQLSDHIQVGVALF------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Homo_sapiens_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWR-------------------- -------------------------------------------------------------------------------- --------------------KLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATG--GPIPQ--RWENVE---- ----------------------------------------------------------------------EPNLDELLVR LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG---YLKGEHGRLLS LWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQ-SREPNGSGRMDGR----EPAQLLLLLAKTQ ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEI------------------- ----------------LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV--MVEEGDNIAQGSGH------------ ----ENSLELDSSIFS-QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL TG-----------ERDTLAGQTVDLQGEVDSLSK----------------------------ERELLQKAREELRQQLEV LEQEA----------WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR--ERERLQEML-------MGLEAKQSESLSEL ITLREALESSHLEGELLRQEQTEVTAALARAE-QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ -------------------------LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA ELQADLRDIQEEKEEIQ---------------------KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV REKAALEVRLQAVERDRQDLAEQLQG-------LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG-- --EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK------TALEQQKAAHEKEVNQ--LREKWEKERSWHQQELAKA LESLEREKMELEM-----------------RLKEQQTEMEAIQAQREEERTQAESAL----------------------- ----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER LRQDMKVQKL-------KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD DSQRLVEQEVQEKLRETQE---------------YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA EQQPGNQA------------------------------------------------------------------------ ----------------QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEA VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ ELEKCRSVLE---------------------------------------------------------HLPMAVQEREQKL TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE--------------HL TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ---------------------- -ARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEI QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK EQEILELRETQQRNNLEALPHSHKTSPMEEQSLK-----------------------------------------LDSLE PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE RLHSPGATSTAELGSRGEQGVQLGEVSGVEAE---------------------------PSPDGMEKQSWRQRLEHLQQA VARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG--QKNSDAKC---VAELQ KEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVLLHPS PSTTQAASR---------- >Pan_troglodytes_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWR-------------------- -------------------------------------------------------------------------------- --------------------KLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATG--GPIPQ--RWENVE---- ----------------------------------------------------------------------EPNLDELLVR LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG---YLKGEHGRLLS LWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQ-SREPNGSGRMDGR----EPAQLLLLLAKTQ ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEI------------------- ----------------LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV--MVEEGDNIAQGCGH------------ ----ENSLELDSSIFS-QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL TG-----------ERDTLAGQTVDLQGEVDSLSK----------------------------ERELLQKAREELRQQLEV LEQEA----------WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR--ERERLQEML-------MGLEAKQSESLSEL ITLREALESSHLEGELLRQEQTEVTAALARAE-QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ -------------------------LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA ELQADLRDIQEEKEEIQ---------------------KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV REKAALEVRLQAVERDRQDLAEQLQG-------LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG-- --EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK------TALEQQKAAHEEEVNQ--LREKWEKERSWHQQELAKA LESLKREKMELEM-----------------RLKEQQTEMEAIQAQREEERTQAESAL----------------------- ----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER LRQDMKVQKL-------KEQETTGILQTQLQEAQRELKEAAWQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD DSQRLVEQEVQEKLRETQE---------------YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA EQQPGN-------------------------------------------------------------------------- ----------------QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSLWGLEPDQNGARSLFKRGPLLTALSAEA VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE TMASLQSRLRRAELQRMEAQGEQELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ ELEKCRSVLE---------------------------------------------------------HLPMAVQEREQKL TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE--------------HL TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGQLKEQSLESQLDEAQ RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ---------------------- -ARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHTRQLEEALRIQEGEI QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK EQEILELRETQQRNNLEALPHSHKTSPMEEQSLK-----------------------------------------LDSLE PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE RLHSPGATSTAELGSRGEQGVQLGEVSGVEAE---------------------------PSLAGMEKQSWRQRLEHLQQA VAQLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG--QKNSDAKC---VAELQ KEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVLLHPS PSTTQAASR---------- >Gorilla_gorilla_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MKPQSLQLVLEEQVLALQQQMAENQAASWR-------------------- -------------------------------------------------------------------------------- --------------------KLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATG--ELTVK--RWENVE---- ----------------------------------------------------------------------EPNLDELLVR LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG---YLKGEHGRLLS LWREVVTFRRHFLEMKSATDRDLTELKAEHVRLSGSLLTCCLRLTVGAQ-SREPNGSGRMDGR----EPAQLLLLLAKTQ ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDHEKMIKALRETVEI------------------- ----------------LVHDPLLWKGVGHGLVDSLCFMICMQCVLTREELANSEYPRDSDNEAMRSTLGLKHPFTV---- ----QRQHPSPIYSPPSPKGEDDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL TG-----------ERDTLAAQTVDLQGEVDSLSK----------------------------ERELLQKAREELRQQLEV LEQEA----------WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR--ERERLHREVSLSFEMLMGLEAKQSESLSEL ITLREALESSRLEGELLRQEQTEVTSALARAE-QSIAELSNSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ -------------------------LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA ELQADLRDIQEEKEEIQ---------------------KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV REKAALEVRLQAVERDRQDLAEQLQG-------LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG-- --EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK------TALEQQKAAHEEEVQI--CGQ--EKERSWHQQELAKA LESLEREKMELEM-----------------RLKEQQTEMEAIQAQREEERTQAESAL----------------------- ----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER LRQDMKVQKL-------KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD DSQRLVEQEVQEKLRETQE---------------YNRIQKELEREKARRVLGLG-------------------------- LKELINSTSQLESRTEKMRNSR---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------LAMPFLSQDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQKEKSKWEGKQNSLESELMELHE TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ------------------------------ -------------------------------------------------------------------------------- --------------------------------------------------------------------------EREQKL TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR ETQRVALTHLTLDLER---------------------------------------------------------------- --------------------------------------------------ARPGADHSEAADAGTGRGR----------- ------------------------------------------------EGPKAYPRTPGAQRPAGAAAPGPAQSQLDEAQ RALAQRDQELEALQQEQQQAQGQE-----------GALEQAHMTLKERHGELQDHKEQ---------------------- -ARRLKEELAVEGRRVQALEEVLGDLRAESREQEK--------------------------------------------- -ESQSSRHQEEAAWARAEALQEALGKVHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHTRQLEEALRIREGEI QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEP------------------------------------------- -------------------------------------------------------------------------------- -RLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVNSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE RLHSPG----------------------------------------------------------MEKQSWRQRLEHLQQA VARLEIDRSRLQRHNVQLRSTLEQ-------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Mus_musculus_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------METGSPGLN-MKPQSLQLVLEGQVLALQQQMAENQAASWR-------------------- -------------------------------------------------------------------------------- --------------------KLKNSQEAQKRQATLVRKLQAKVLQYRSWCQDLEKRLEATG--GLIPQ--RWESVE---- ----------------------------------------------------------------------EPNLEQLLIR LEEEQQRCESLVEVNTELRLHMEKADVVNKALQEDVEKLTVDWSRARDELVRKESQWRMEQEFFKG---YLRGEHGRLLN LWREVVTFRRHFLKMKSATDRDLTELKAEHARLSGSLLTCCLRLTLRAQ-SRESSGSGRTEES----EPARLLLLVAKTQ ALEKEAHEKSQELMQLKSHGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRETMEI------------------- ----------------LVCG-------------------------------------------PLCCR------------ ----GAKKGLAGS--------------LLFVDK----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Rattus_norvegicus_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MEKADVVNKALQEDVEKLTVDWSRARDELMRKESQWRMEQEFFKG---YLRGEHGRLLS VWREVVTFRRHFLKMKSATDRDLTELKAEHARLSGSLLTCCLRLTLRAQ-SRDSSGSGRSDES----EPAQLLLLVAKTQ ALEKEAHEKSQELMQLKSQGDLEKAELQDRVTELSALLTQSQKQNKDYEEMVKALRGTMEI------------------- ----------------LETNHAELMEHEASLSRNAQEEKLSLQHVIKDITQALASVEEEDTVTQTPGS------------ ----ENSLQSDYNDLS-QFDSQDPNKALTLVHSVLTRRQQAVQDLRQQLSGCQEAMSFLQQQHNQWEEEGKALRERLQKL TG-----------ERDALAGQTVDLQGEVDSLSK----------------------------ERELLQTARGELQQQLEV LEQEA----------WRLRRVNVELQLQGDSAQGEKLEQQEELHLAVR--ERERLQETL-------VGLEAKQSESLSEL IALREALESSRLAGELLKQEQEEVAAALARAE-QSIVELSSSENSLKAEVADLRAAAVKLGALNEALALDKVALNQQLLQ -------------------------LEQENQSMCSRVEAAEQLRSALQVDLAEAERSREALWEEKTHLETQLRKAEETGA ELQAELRGAREEKEELK---------------------EKLNEAHHQQEAATAQLQQLHQDAERQEEALARAGQEKEALV RERAALEVRLQAVERDRQDLAEQVLG-------LRSAKEQLEGNLFEAQQQNSVIQVTKSQLEVQIQTIIQAKEVIQG-- --EVKCLKLELDTERSHAEQERDAVARQLAQAEQEGQ------AALERQKVAHEEEVNR--LQEKWEKERALLQQKLDKT LETLERERTELEM-----------------KLREQHTETEALRAQREEERTQADSAL----------------------- ----------------------------------------------YQMQLETEKERVSLLETLLQTQKELADASQQLER LRQDMKVQKL-------KEQETTGMLQAQLRGAQQELKEAIQQHRDDLAAFQK-------DKIDLQKQVEDLTSQLVTHN DSQRLVKQEIEEKVREAQE---------------CSRIQKELEKEKASLTLSLVEKEKRLLVLQEADSVRQRELVSLRQD IQEAQEGQRELGVQVELLRQEVKEKEADFVAREAQLLEELEASRIAERQVRASLWAQEAKAAQLQLQLRSTEAQLEALVA EQQPEN-------------------------------------------------------------------------- ----------------QAQAQLRSLYSVLQQALGSACERRPELRGGGDSVPTPWGSDPDQNGASRLLKRGPLLTALSAEA VALALQKLHQDLWKAQQARDDLRDQVQKLVQRLTDTEAQKSQVHSELQDLQRQLSQSQEEKSKWEGKQNSLESELRDLHE TMASLQSRLRQAELQKMEAQNDRELLQASKEKLSAQVEHLQACVTEARAQASAAGVLEEDLRTARSALKLKNEEIESERE RAQALQEQGELKVAQGKALQENLTLLAQTLSNREREVETLQAEVQELEKQREMQKAALELLSLDLKKRSREVDLQQEQIQ ELEQCRSVLE---------------------------------------------------------HLPMAVQEREQKL SVQRDQIRELENDREAQRTALEHQLLDLEQKAQVIESQRGQIQDLKKQLGTLECLALELEESHRKVEGQQKVITELEGQR ELQRVALTHLTLDLEERSQELQTQSSQLHELENHSTRLAKELQERDQEVMSQRQQIEELQKQKE--------------QL TQDLERKGQELVLQKERIQVLEDQRTLQTKILEEDLEQIKHSLRERGQELASQWQLMQERAEDGKSPSKAQRGSLEHLKL ILRDKEKEVECQQERIQELQEHMGQLEQQLQGLHRKVGETSLLLTHREQETATLQQRLQEAKEQGELREQVLQGQLEEAQ RALAQRDHELEALRQEQQQTRGQEESMKQKTSALQAALEQAHVTLKERQGELEEHRGQ---------------------- -VQRLQEELIVEGRQVRALEEVLGDLRAESREHEKTVLALQQRCAEQAQEHEAEARTLQDSWLQAQATLAEQEQELEALR AENQYSRQQEEAAFGQAEALQEALSKAQATLQEKEQRLLEQAELSCTLEASTATLQATLDTCQARARQLEEALRVREGEI QTQALQHQEAMQHLQQELCQKEEDLRQQDEQRQLLEKAVAQRSQENGIQEKQSLEQEKEEE-TRGLLESLKELQLTVAQK EEEILMLREAQQRQNQEASSPSHRSFPAEKPSLQ-----------------------------------------L---- LLAQQDLERLQNALRQTEAREIEWREKAQGLALSLAQSKASISSLQEIAMFLQASVLERESEQQRLQEELVLSRQALEEQ QSRGPHSSSRADQGPKAGQDTEPGE--VIEAE---------------------------PSPGVGEKEQLRQRLERLQQA VAELEVDRSKLQCHNAQLRTTLEQVERERRKLKRDSLRASRAGSLEARETMNSSPTQQDGRGSQRGSSDSML---MVELQ REVALLRAQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLTVAQAPEATVLEAETKKLDESLNQSLTSPAP-FLHPS LDTTQNTHR---------- >Canis_familiaris_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------METRGPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWR-------------------- -------------------------------------------------------------------------------- --------------------KLKNSQEAQQRQATLVRKLQAKVLQYRTWCQELEKQLEATG--GPTPQ--RWESME---- ----------------------------------------------------------------------EPDLEQLLVR LEEEQQRCESLAEVNTQLRLHMEKADMVNKALREDVENLTVDWSRARDELRRKESQWQMEQEFFKG---YLKGEHGRLLG LWREVVTFRRHFLEMKSATDRDLTELKAEHVKLSGSLLTCCLRLTVGTQ-SRESDGSGRRDGS----EPTQLLLLLTKTQ ELEKEAHERSQELIQLKSRGDLEKAELQDQVTELSALLIQARKQNEEYEKMLGALRETVEI------------------- ----------------LETNHAELMEHEVSLSKNAQEEKLSLQQVIRDITQV--MVEEGDSMTQGCGR------------ ----DSSLELDPSGLSSQFDSQDPDKALTLVRSVVTQRRQAVQDLRQQLSACQEAMSSLRQQHNQWEEEGEALRQRLQKL TG-----------ERDTLAGQTSDLQGEVESLSK----------------------------ERELLQKTREELQQQLEV LEQEA----------WRLRRTNMELQLQGDSVQGEKEEQQEELHLAVR--ERERLQETL-------ASLEAKQSESLSEL IILREALESCHLEGELLRQEQTEVTAALARAE-QSVAELSSSENSLKAEVADLRAATIKLSALNEALALDKVGLNQQLLQ -------------------------LEQENQSVCHRMEATEQARNALQLGLAEAERSREALQEKNTHLEAQLQKAEERGA ELQADLRAIQDEKEEIQ---------------------EKLSEARHQQEAALAQLDQLRQETKRQEEVLAREVQEKEALV RERAALEVRLQAVERDRQDLAEQLLG-------LSSAKEQLESTLFEAQQQNSLVEVTKGQLEVQIQTVIRAKEVIQG-- --EVRCLKLELDSERNQAEQERETAARRLAQAEQEGQ------TALQQQKSAHEEEVNR--LQEKWEKERSWHQQELDKA LESLEKEKMELET-----------------RLREQQAEAEAIRTQREEERAEAESAL----------------------- ----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER LRQDMKVQKL-------KEQETTQILQAQLREARGELEQAAQQNRDDLVAVQEECGALLQAKMDLQKRVEELKSQLVSRD DSRRLVEQEVQEKLREAQE---------------YSRIQKELEREKASLIQSLMEKEQRLLVLQEADSVRQQELSSLRQD MQESQEGQKELSTQVELLKQEVKEKEADFLAQEAQLLEELETSQVTEQRLRASLRALEAKAAQVQLRLRSTENQLAALVA EQQPGH-------------------------------------------------------------------------- ----------------QAQAQLASLCSVLQQALGFACESRPELRGGGDSAS-LWGPEPDQNGTGILLKRGPLLTALSAEA VASALQKLHQDLWKTQQARDDLREQALKLEQRLTDTEAEKSQVCTELQDLQRQLSQNQEEKSKWEGKQISLESELTELHG TVASLQSRLQQAELQGLEAQ------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------DELELTRQALEKE QLLSSSSTSRAEQRPRE-------EVSEVEAE---------------------------PSLGLEERQLWGQRLEYLQQA VAQLEIDRSRLQHHNVQLRATLEQVERERRKLKRESMRVSRTGGLEVKEAAASSPTQQDGRGGQKGSSDDKQ---MAELQ KEVAMLRGQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRKLDESLTQSLTSPGPALLCPS PSTIQAISR---------- >Felis_catus_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------METGGPGSNNMKPQSLQLVLEKQVLALQQQMAENQAISWR-------------------- -------------------------------------------------------------------------------- --------------------KLKSSQEAQQRQAALVRKLQAKVLQYRTWCQELEKRLEASGAKGPISP--RWESVE---- ----------------------------------------------------------------------EPSLEQLLVR LEEEQQRCESLAEVNTQLRLHMEKADMVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG---YLKGEHGRLLG LWREVVTFRRHFLEMKSATDRDLTELKAEHVRLSGSLLTCCLRLTVGAR-SGEPDGSGRLDGS----ESTQLLLLLTKTQ KLEKEVHERSQELIQLKSQGDLEKAGLQDRVTELSVLLTQAQKQNEDYEKMLKALREAMEI------------------- ----------------LEKNHAELMDHEASLSRNAQEEKLSLQQVIRDITQV--MVEEGDGMTPGCGH------------ ----ESSLELDPSGDSSQFDSQDPGKALTLVRSVVTRRRQAVQDLRQQLSGCQEAVSSLRRQHDQWEEEVKALRQRLQKL TG-----------ERDTLAGQTTDLQGEVESLSK----------------------------ERELLQKTREELQQQLEV LEQEA----------WRLRRTNMELQLQGDSAQGEKEEQQEELHLAVR--ERKRLQETL-------AGLEAKQSESLSEL ITLREALESSHLERELLRQEQTEVTAALARAE-RCVAELSSSENSLKAEVADLRAAAAKLSALNEALALDKVGLNQQLLQ -------------------------LEQENQSMCSRMEAAEQARSTLQLGLAEAERSRDALQEKNTHLEVQLQKAEETGA ELRADLRGIQEEKEEIQ---------------------EKLSEAHHQQEAAFAQLEQLHQEMKRQDEVLAREVQEKEALV RERAGLEVRLQAVERDRQDLSEQLLG-------LSSAKEQLESNLFEAQQQNSLIEVTKGQLEIQIQTVTRAKEVIQG-- --EVRCLKLELDTERSRAEQERENAARQLAQAEQEGH------TALQQQKSAHEEEVNR--LQEKWEKERSRHQQELGKA LESLEREKMELEM-----------------RLTEQQAETEAIRTQREEERAEAESAL----------------------- ----------------------------------------------CQMQLETEKERVSLLETLLQTQKELAEASQQLER LRQDMKVQKL-------KEQETTELLQTQLRDARQELEQAAQRDRGDLAGLREECRALLQAKTDLQEQVEDLKSQLVSKD DSQRLVEQEIKEKLREAQE---------------YSQIQKELESEKASLIQSLVEKEQRLLVLQEADSVRQQELSSLRQD LQEAQGGQKELSAQVELLKQEVKEKEADFLAQEAQLLEELEASRVTEQQLRASLRALETKAAQVQLRLRSTENQLAALAA EQQPGQ-------------------------------------------------------------------------- ----------------QAQAQLASLCSVLQQALGSACENRPELHGGGDSAS-LGAPEPDQNGARILFKRGPLLTALSAEA VASALHKLHQDLWKTQQARDDLREQAQKLEQRLTDTEAEKSQVCTELQHLQRKLSQNQEEKSKWEGKQISLECELTELHE TVASLQSRLWQAELQGIEAQNERELLQAAKENLMAQVERLQASVAEARAQASAAGALEEDLRNARSALKLKSKEAETERE RAQALQEQGELKVAHGKALQENLAILAQTLSKREGEVETLRGNIQELEKQREMQKAALEVLSLDLKKRNQEVDVQQEQIQ ELEKCRSVLE---------------------------------------------------------HLPMAVQEQEQKL AVQREQIKELEKDRETQRNILEHQLLELEKKAQVIESQKGQIQDLKKQLVTLECLALELEENHHKMECQQKAIEELEDQR EVQRLALTHLTLDLEERSQELQAQSSQIHELESRSTLLARELQDKDQELQSQREQIEELQRQKE--------------HL TQDLERRDQDMVLQRERIQVLEDQRTLQTKILEEDLGQIKLSLRERGRELASQRPLMQERAEEGKGQSKAQRGSLEHMKL ILRDKEKEVECQQERIQELKEHKGHLEQQLQGLHRKVGETSLLLTQREQELVVLQRHLQEAREQGQLKEQSLQGHLEETQ RALAQRDQELEALQQQQQQVQGQEESMKEKASTLQRALEQAHAVLKERQGELEDHKEH---------------------- -VRRLREELVVEGQRVQALEEVLGDLRAESREQEEALLALRQQCAERAQEHEVEIRGLQDSLLQAEAMLKERGRELEAVQ ADGRSSQHREETARARAEALQEALSEAQATLQEKEQRLLGQAELSRNLEASTATLQAALDSCQAQARQLEEALRRREGEI RDRDLRHQEAVQQLQRALAQRDDELSHQKRQGQLLEQSLAQRDRED--QGKQGEGREREEEEMRGLRESLRELQLTLAQK EEEILGLREAQQRKNLEDSPHSHTASPAEEPSTQ-----------------------------------------FDALG PRLQQELERLQAALRQTEAREIEWREKAQDLALSLAQSKASVSNLQEVAMLLQASVLERDSERQRLQDELELTRQALEKE RLFSPSLTSRAERGPREEVGVQLEEVPGVEAE---------------------------PSPGMEEKQLWGQRLEQLQQA VAQLEIDRSRLQRHNVQLRATLEQVERERRRLKRDSMRALRTGILEVSEA-----TQQDARGGQKGTSDAKH---MAELQ KEVALLRAQLALERKQRQDYIARSTQTSRELAGLHHSLSHSLLAVAQTPEATVLEAETRKLDESLTQSLTSPGPVLLCPS P--TQATSR---------- >Myotis_lucifugus_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------METGGPGLNNMKPQSLQLVLEDQVLALQQQMAENQAASWR-------------------- -------------------------------------------------------------------------------- --------------------KLKSSQEAQQRQAVLVRKLQAKVLQYRSWCQELEKQLEATG--GPIPQ--MWDSVK---- ----------------------------------------------------------------------EPNLEQLLMR LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELIRKESQWRMEQEFFKG---YLKGEHGRLLS LWREVVTFRRHFLEMKSATDRDLTELKAEHVKLSGSLLTCCLRLTVGTQ-SRESDGSGRLDGS----APAQLLLQLAKTQ ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRETMEI------------------- ----------------LETNHAELMEHEASLSRNAQEEKLSLQQVIKDITQV--MVDEGDNMSQGSGH------------ ----ESTLELDYSDFSSQFDSQDPDKAVTLVRSVLTQRRQAVQDLRQQLSGCQEAVSFLQQQHNQWEEEGEALRQRLQKL TG-----------ERDTLAGQTVDLQGEVDSLSK----------------------------ERALLQETREELQQQLAV LEQEA----------WRLRRTNMELQLQGDSAQGEKEEQQEELHLAVR--ERQRLQEML-------AGLEAKQSESLSEL ITLRENLESSRLEGELLRQEQTEVTAALARAE-QSIAELSSSENSLKAEVADLRAAAAKLSALNEALALDKVALNQQLLQ -------------------------LEQENQSVCSRMEAAEQARNTLQVGLAEVERSREALWEKNTHLEAQLQKAEETGA QLQADLRSIQEEKEELQ---------------------EKLSEARHQQEAASAQLEQLHQEAKRQEEVLAREVQEKEALV REKAALEVRLQAGERDRQDLSDQLLG-------LSSAKEFLESSLFEAQQQNSLIEVTKGQLEVQIQTVTQAKEVIQG-- --EVRCLKLELDTERNRAEQERDTAARQLAQAEQEGQ------TALQQLNSAHEEEVNR--LQEKLEKECSRHQQELDKA LETLEKEKMELEM-----------------RLREQQAETEALRTQKEEERAKAESAL----------------------- ----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER LRQDMKVQKL-------KEQETIGMLQTQLREARRELEQAAQQHRDDLTALQGESSSLLQDKIDLQKQVEDLKSQLVSKD DSRRLVEQEIQEKRREAQE---------------CSRIQKELERDKASLTLSLVEKEQRLLVLEEADSVRQQELRSLHQD LQEAQGGQKELSAQVELLKQEVKEKEANFLAQEAQLLEELEASRVTEQQLRASLWAQEAKEAQLQLRLRSMESQLEALAA EQQPGH-------------------------------------------------------------------------- ----------------HAQAQLASLCSVLQQALGSVCESRPELSGGGDSAPSFWGPEPDQNGTRILFKRGPLLTALSAEA VASALHKLHQDLRKTQQARDDLRNQAQKLKQHLTDTEAEKSQVQTELRDLQRQLSQNQEEKSKWEEKQKSLESELMELHE TVASLQSRLRRAELQGMEAQNERQLLQAAKENLTAQVQHLQASVTEARAQASAAGVLEEDLRTARSALKLKNEEVESERE RAQALREQGELKVAQGKALQENLAILAQALSEREGEVEALQEKIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ ELERCRSVLE---------------------------------------------------------HLPMAVQEREQKL TVQREQIKELEKDQETQRNVVEHQLLELEKRDQVIESQKGQIQDLKKQLVTLECLALELEENHRKVECQQKAIEELESQR EVQRVALTHLTLDLEERSQELQVLSSQVHELESHSSLLAGELQEKDQEVKSQREQIEELQRQKE--------------RL TQDLQRRDQEMVLQKERIQVLEDQRTLQTKILEEDLEQIKLSLRERGRELASQRQLMQERAEEGKGQNKAQRGSLEHMKL ILRDKEKEVECQQERIQELQEHKGQLEQQLQGLHRKVGETSLLLTQREQEIVVLQQHLQEAREQGELKEKSLQGQLEEAQ RALAQRDQELEALQQQQQQAQGQEEVVKEKAGTLQRALEQAHMTLRERQGELEDQREH---------------------- -VQRLQEELTVEGQRAQALEEVLGDLRAEFQKQEKTLLALQQQCAERAQEHEAEAKALQDSWLQAEAMLKQRDQELEALR ADSQSSQHQEEAARGQVEALQEALSKAQAALQEKEQHLLGQAELSRSLEASTATLQAALDSCQAQARQLEEVLRKREGEI QDRDLRHQAAVQELQQALAQRDGELRHQRKQRQLLEKSLAQR-----LQE-----DEREEE-MRGLYESLRELQLTLAQR EEEILELREQRKNLEASAHSRKAS--PVEEPSTK-----------------------------------------LDSLG PRLQQELERLQAVLRQTEAREIEWREKAQDLALSLAQSKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRQALEKE RLHSPGPTSRTEQGPRGEAGGQLGQVSGGEAE---------------------------PSAGTQEKQPWEQRLEHLQQA VAQLEVDRSRLQHHNIQLRTTLEQVERERRKLKREFLRTSRSGVLETSEATASSPTPQVYLFIDCSLSCSLP---LGFPA QQVALLRAQLALERKQKQDYIARSVQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRKLDESLTQSLTSPGPVLLCPS PSPSPRASQ---------- >Monodelphis_domestica_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------MEARDQGHN-MKPQPLNMVLEKQILALQQQMAENQAASWH-------------------- -------------------------------------------------------------------------------- --------------------KLKISQEAQQRQAVLVRKLQAKVLQYRNWCQELEKRLEDMG--GPMPK--RWTSAE---- ----------------------------------------------------------------------EPRLEQLLIR LEEEHQRSEGLVKVNTQLQEHLEEADVVNKALQEDVGKLTVDWSQAQDELARRQSDWQMEREFFKG---YLKGEHGRLLS LWREVVTFRRHFLEMKTATDRDLAELKAEQVKISGSLLTSCLHLSLELQ-SREAQGSGRLAGN----E-QVHLQLVAKTQ ELEKEIHKRSQELILLKARGNMEKTELQDRVTELSALLAQSKKQNEEQEKMLKALKDTMDI------------------- ----------------LETNRSELMEHEASLSRNSQKEKLSLQQVIKDITQV--VVDDEDSENQSFGL------------ ----ESSLEMESSIFC-QLRSEDPDKAVTLVRSILAKKHQAVQGLRQQLSTCQEAVSFWQHQHTQWEEEGEALRQRLQKL TG-----------ERDVLAGQTQGLQGEVDSLNR----------------------------DRGHLEKAREELQQQLEI LEQEA----------WRLRRLNTELQLQGDLAQGEKVEQEEELQQAVR--ERDCLQETL-------KGLEARQSSSLSEL ISLKEALEKSHLEGELLNQERAEMARALAKAE-QSIAELTGTERTLKAEVADLRDAAAKLSALNEALALDKVELNQQLLQ -------------------------LEQENQSVHGKVEASEKARSAVQMELDESEQRKEALLEEKACLEMQLQKSKDAEA ELQGDLSREREEKIETQ---------------------EKLNEAQRQLEVATTELEQLHQETTRQELLREKVIQEKEILV RDKAALEVHLKALERDQQDLSEQLLE-------LSSAKELLETNLFEAQQQGSLMEITKEQLMMQIQTVTQAKEVIQG-- --EVKCLQMELEAQRQQAEQEQDTAAKHRDQMEQESQ------AALQQQRATYEEELHL--LQEE-RMDQIKHRQELEAT LEQMKREKVDLEETC-------------EKKLRELQEESEAALAQRIKDHAQAESNR----------------------- ----------------------------------------------CQMQLEMEKERMSLLETLLKTQNELADAGHQLEQ LRQDIKDQKL-------KEQENMEDLWAQLQEAQKTLMETRRKHHNDLAALEEEKSILLQQKENLEQQVQDLKAQLVTSE DSCRLAEHEAQKHLQEVQQ---------------CTHIQEEREQEKASLVQSLAEKEQRLLILQEADSLQQQELSSLRQE VKEAQEEQEQLSAQVLFLKEEMQKKEASLLDQEI-LLEKLGASKKTEQQLRASLWAQEAKAAQLQLQLCSVESQVGALIL EQQNGH-------------------------------------------------------------------------- ----------------QAQAQLMGLYSILQQAFGSAIESRPELSGAGDASPLSWSPRTLEPGQENFLKNQIAVTNFTTED VASLLHKLQRDLWQARHTRDDMKCQVEKLEQHLSQAEAERNQFSTEIQELQSLLSQNQKEKLKWEGEQSSLETELAVLQE RVASLQNSLKRSEQQRTEAQNEQATLWAANEKLVSEVEHLQASVAVTKAQANAREALEAELRATHSALRMKNEEAESERE KAEALR----KKLAQGKALQENVDLLTSTLSKREKELEALQGVIQELEKQRESQMVMQEHLSLNLKKRSQELESRQEQIQ ELEKQKAGLE---------------------------------------------------------HLPVALEQKKKQI RLQREQIKELEGKQETQGNILEHQALDLQKKTQTLESQREHIQDLENQLVTLEHLVLEVKKNHQEIESQKKKIEDLENQR EMQRVTLTHLTLDLEEKSQEIQSQNKKIKELEKHNALLTVNLEERCQEMKSYRDQVEELKKQKD--------------QL TWDLEKKNQELVLQEEKILVLEDQRMLQNRVLEEDFEQMKLALREKDQEIESQRQLMIEREEEEKGQAKAQRSSLEHMKL ILRDKEKEVEYQRERIHMFQQYGEQREEQLQGLRRKIGEMTLLLTQKDQELETQQQHIRRVQERRESRERALQDQLERVQ EALQTKVQDLEALQQKAQLQQESQE---EQMSTLQAALEQARAALEEHEEAIEAHKEQ---------------------- -NQKVQQQQTAAELQVQALEELLGDLRAEFQEQEKVLETLRQQCTEQGHEQETQAWH----------------------- -QHTEARQWEKTTAGQVQALKEALRVAQASLQKKDQELLQQAELSQRLEGSAAALQVALDSCQTQARHLEEALREREEEI REQQLQHQEMVQQLQLALAQRDGELRQLKEKGQQQEAALNQSD-------------KGEEKEEKVLRQNLRHLQLTLSRK EFQLQETHRRHGQESYYESHSPEKMEDGEEEEVYGTGTM--------------------------EKMSLREISPVSMEE AKLQEELERVKNVLRQTEAREIEWQEKAQALAFSLAESEASICNLREAALFLQAKTAEQNTEQLQLEEQLQLTRQALEDE QSHNRGSAWRTEPEIQGDEGTSQRKATGPEDDG--------------------------SCTELEKTQQWQQRLKYLLHA MASLEHERNRLQRHNFQLRVTLEQVERERRKLKRNFNRMTHTTPPLPRETTALTPGQKQEKGGQENSSELKH---VAELQ RQVTALQTQLALERQQKQDYISRCVQTSRELTDLHHNLSNSLWAVARAPEANILEAEARKLDKSLTQSLTSSAPSPPCCT PRSAQATSRS--------- >Gallus_gallus_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MAAREAARGQACLRR-------------------- -------------------------------------------------------------------------------- --------------------RLHGAEEAQQQQAVLVRKLQEKLLQYRSWCRELEQRLEAGGVSVQGSLSYRWETTE---- ----------------------------------------------------------------------DHSLEKALLQ LEEEQQRCENLAEVNTLLREHLDKANEVNLALKEDVGKLTADWMRAREELELKESEWRSEREFYDS---YLRGEHNRLLS LWRQVLTFRRHFLEMKTATDRDLSELKAEQMRLSGSILVSCFRLNSGVQ-LWESVTLGRPVLK----DQAQQQVEREINQ EALEVMCLQVDEDLEKKEL--------QDRVMELSALLVQSQKQNEEKEKTVKTLNDTVEM------------------- ----------------LEASRLEV-EYEASLTKNAKEENLALQKLIKEITEVVLDDSDSTVGIVQ--------------- --------RPESSNVLSCLSSLDAEHAFVLVQETLARRQKAIQALKEELSTRQDSISFLQHQHRQQEEKCKKLQQRLEQL EE-----------ENKMSNSHQQHLKSLVLALKC----------------------------DCENLEKIRGELQQKLEL SEQEA----------SRLRQSNTELQLKEDSAQGEKVEQQLAMERAHH--DHELVLKDL-------AALEEKHSLLQNEL VAAREKLEESHLQRDLLKQEKHELTVALEKAE-KSVAALTGAQNKLNSEIADLHTAAAKMSSINEALALDKVELNKLVLQ -------------------------LEQENELLSDKVNEMERAKVSEQEKITLYKRTNEELCAEKSHLEKLLKKAEEQQE ELQMQLRILAEEKEETL---------------------EKLNQVYRQQESASSGLEQLRQQSSRQEDAVAKVSKEKEFLV HEKAALEVRLAAVERDRQGLSEQLAE-------ARSVKDTLESSLFEAQQQLSHLEITKSQLEIQLHTVVQAKEVIQG-- --EVKCLQYELETERCLMKQEQKNMAQRLIQIEEQHN------NTLKLQQTDHEVEINK--LLQDLASEREGRQLELQEM LELWEKEKAEAEGQH-------------EKKLFHMKEKVATMQAQQEEERTRVESAN----------------------- ----------------------------------------------QEILTEKENEKKALLETLLQTQGELTEACHQLEQ LRQEVKEQQE-------YEQNITEKLQAELQETHCKIKMVENMHKEEMENIKEEKNILLQQRDDLQKQVEELTSQLAASE ESHQAIGHKAQQELSEAQE---------------LSRQKVLEVVHLQKILEEERGQWEEVEHQNKELQ------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------VCLQSLEGERSRWEEVERHNTEFQASLKALESERERLSLSLEQKELSLKTLEEN NLVQQNEVSKLHSAIQQAQQLHSDHRREIQELNNQVQTLQEVVLEKEASLAAREKQLLQDLEESRAGERCLRDSLHVLEA EMAELHLRLCSTENRAKALATECQQANNAHCEAQSQLDKLHLVLHHVLCD------STDKSRDLVAWSSGKSGRDENYVE CLGMKENMEGRDGSSQSY-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Anolis_carolinensis_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------ME-GDQAAHSMKMESAHLS-DDQLVSVHQQMIESQASYRN-------------------- -------------------------------------------------------------------------------- --------------------KLQNSQEAQHRQAILVQKLQGKVLQYRNWCRDLEQRLEASR-ASYSL---RQDNKK---- ----------------------------------------------------------------------DHSLEKALIQ LEEEQQRCQNLAGVNILLRDHLDKANEVNGALREDVSKLTADWTKARDELEYKESEWHKERKFFES---YMRAEHDRIIG IWRQVVTLHRYFLEMKTATDRDLSELKVEQMRLSGSILISCFQLSSDTR-LLEMSNLESSVLKGSLQQQQQQLYLKPEKT DMEKEIYQQTQAIMNLRVKGDLAREDLQSRVIELTALLEQSQKENEEKEKTVKTLRDTLEK------------------- ----------------SNHLELEY-EQEQSRSKTVNEEILSLRHVIKEITEAVLNGNDATVGKPQVEQS----------- -------AELGHS---LQLDPGGLDGTLLLVREALMKRSNEVQHLRQQLLASQNSITSLEKQQEQQEEHSRFQGQRLEQL EK-----------ERETFTSQIQHQQSTIETYSR----------------------------DYATLEKSRTELQQHLEV LEQEV----------WHLRQNNTELQLKGDMVNGEKEEQQQELQRMMR--EREYIQEDR-------NALEERHSSLKNEL IALREALEKSHLDGELMKQEKYELASALEQTE-QSLAQLTSAHNKLKAETADLQGATAKMSALNEALALDKVGLHQIILK -------------------------MEQESQMLSDNVDRLEKMKSLSQKQLKQAEQTNEELCTEKIRLEKLLQKAEELQE GLQDELKMLKEEQKETY---------------------EKLSQVHHQHEKSISSLEQAHQESNRLGEMYAKVSKEKEKLM CEKATLEVRLGAVEREKSALTEQVTE-------LRSVKDLLESSLFQAQQQVSQLEVAKGQLEMKVHAISQAKEVIQG-- --EVKCLRIELEAEKSRIEQENEERVQLLSQAEQKHQ------ETLSHRQIVHKEEMNA--VFQELEGERERHRVELEEA LKRSAKEKEESESTC-------------EQKLLELQKNITAIQTRMEDELFKAQNAK----------------------- ----------------------------------------------QELLFEKENERKSLLDELLQTKDKLTSTCQQLEY FRQEIKKHQE-------EAQVTVQGLEADLKDAQHRMKTLEKKHKEEIKSLKEEINILLQQRDALRSQVQELESQLLIAK DSCQSISQEAQHHLREGQE---------------LSKQKELEIAHLRKMLEAERKRCEEISHQSIELQSQKEEMEHRNTE LQAMLQNQWEAEKHLNRELQRKQEEVQRQCATLQALEREQNLWVEADRQNSEQHNVLQRQLEEAKFQNKQLQTQKREADL QNAKLLHQKEELECQNAQLKDALQSQREEAECESTILQSHWE------------EAQQRYSELQNWKEKIEDENAELQAL LSHQREKMESQNMELQSKQKEIEHQNIVLQKMKEERSHWEEVEDQNSELKAALQTMEQKRASLALSLKETEDRAKKLQES DDAHKDEIAKLSTALQLTEQLLAEYRKEMQELNNEIQSLKQKTAEKEAALVAQQEQLIQDVEESHTSEQRLKDSVQVLEA EVSTLRQSLRSTESRAEALASECQRACSARWEAQSQLSKLHSVLQYMLCNGLEVKVEHGGHGDNNIWNSLSLRTEQDKLI RPALSQSKDFSTELTVERVTEAIQKLRKDLWQSRLERDEVRNNMEKLKQQLIEKEGERDRISAKAQELQKWFNESQEEKN KAEGKRGSLESALKTEVIAFKEENVTLRRRLITLEKTLESTEKQRKDMLDERDSLQMAKDKLSWELDLLRESIRASEIQT NAMEKINQSLEQELQTALSALKTKNEELETQQKKLATLHQEAEIGKTLQENVDRLTASLEKKEEEIKFQLQQIKDLERHR EVQKTTMEHLAESLEKRTQETECQKNQIEEVKKQEKMQKADLERLNLELEKSLQIMQSQQEKIQKLEDLTQTQSTILKSL TLDLEAKVKETQIKEEKIQILEKNESSQIGSLLKELGDLKMQLTEKDWELASQKQLLQECEEQGKKQEKCLHTRLEHMKA ILMDKEREVASREEQIAGFQQHEAQRDSHLCDLNEKVKELAFTVAQRDEELESQRQQIREMEGEMETELKTLRELTAKTQ LSLKERNIELEFQRKHAEEVERQIKILLGDVQISTAVLNLEDNNAEFQKDQKEQLKKQTVLNMLEQLRVLLIRKEREIKS LKEQQDEHKEENEKTVREMQTNLQQALENKEVQLQCLKEENRQLHQLEEKAAAQTKSVMENLEFTRTSLHDREKEIQSLK GHIREISRQKEVEQNKAVSLLNDLNKIKQSRTEKENELLRQVEHIRTYQVKLEATQAELQACQTRVNELQSVIKQKEEEN ERDFKRLRHKHEPVQENDKHPGENEEYLEEKQRKKGEEMDAQNKQEKIKDEMKMLQENIQQLQHLLKKKDDEVEWQKRKV EELKERVKSKEKELLISSEHLKEIVSFLNLQDNEDDNLQSHIQKLHMWKELEIVRSKALQEKDQWLTRQKEKIQQLEDEK KVKKQELDHVTAILKKTESGEIEWREKAQRLDLSLAQSEEALRALREEMTIMQNMVSERDRDRHNLQEQLDTAFRTLEEE RTATKALVGDVDQFISEKHLPEILGKEGEEAMRKGG-----------------------KLSWVDERRFLCRRLQLLQQA VARLENDYRVLEQHNTQLREALKQVEHERRRLKRSCGDLSLSFGLS---QINAGPLKIPSIEKEETQVLHKE---LEKLQ KQVFVLQKQLSLQKKQKQDYIDSCARTNHELSGLHQELSDSLAAVAKEPEATVLALETQKLDETLNYSLSLASGSCNGFF AGKHLISSTPKRLQQKDSK >Ciona_intestinalis_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------MLREQLVSANDSNAALADDLRKVTDDWNDVKQELKTKESEWREEQENFS---SYFGDEHSRLLA LWRAVVQIRRGFGDLKSNTQRDLAQAINDVQRGARQLHASCLNLNANQSVQDTSAKVSLEKERG---EKGDVEEQLRRKV ---KEMLSMQSDFDTEKARLN-------GRINELTVAYDRAKSQLSDKDRTIDDLRTP---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Drosophila_melanogaster_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MQAYRDNFKQTPCPS AVDLQAAG------------PAHQSATASRLPFSR--SQRGRDPSASGASVSASVAGGLTP------------------- -----------------------------------------------RMMSPGPPGAGGGGGGGVSGGGSGDPSALLRQN QELRQRLADESHS----YRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHETIKPTAGVGPKLTTGPTNQVL CSTSLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAG--------------------------------AAELCRK LEEEHQRCEQIVAQNSALRQQLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQAFK---DYYNSEHNRLLK MWREVVAVKRSFKEMQTAMKAEVAKMGQEINCVGKDINGSNATVAFAVQQAKRAADDELKQSQR---SND----ELQNQL ATLKVQYESARHEIMERDQRLL-------ELMNQLKKLEDRCAQAESQAALASRYSDEIER------------------- ----------------LNNSMREIAQAVVQDAEN---ADREADAEVTGGVMQHMHLTRDAASVVGGAGGAGSTAG----- -----GGGKSPRRNS-TRASQAFAEGTISAVQAALHKYQLALHDMQVKFQNTSETLRTTKAQLETSEGTKQLLTTKMQQL TE----KLDSSNSKLSELLQERESLQRGLDDIRV----------------------------QKQQSEMGRADINSAFEN LSSDY----------EKMQLNCGKLQKRIDSMEEDKKAVELEIQRILK--DKNITELNLRS-------EEDRSSRLREET ISLREELNRVSLNRDLLEQQRIESDNLINLLE-KQKSDLEYDLDKLLLEKCDLQEKHEKLSNNSCSTSDELKSVQNCLQE -------------------------AQEERKKLRIQSVDQCNEIGELKKELAILDKARLELETDNLSAGEKLKCLQLEKE KILQDLACVTRDRGDIH---------------------NQLTAMCRKKEALNEELMRTRQRLEQTTETNSRLNRNLEEMV KDVEEKQVVIDLHEKDTHRLNELLAA-----LRSEK--ESLESVLFDTNTSLEATEERRSQLERDLQEALVREESLKN-- --HVARLQKELEQCQRKAQETKTQLLNAARAAESDFN------QKIANLQACAEEAAKR--HGEEILQLRNALEKRMQQA LQALQTAKDDEIEKL-------------QERLATLQAHLESLVQQHEEALIRAES------------------------- --------------------------------------------EKQQALLIAHRDKQAVAERLEAVSRDLKTEQESLDR SRREANARDEKQRA-------AIAQLKDEMVQMRTKEEEHKIKLEECIRKQELQLSSLREERESLCR------------- ----------------VSEEL-------------KMEIRLKEDRMES-TNNELQDALRKSKEGEGFIDSLRKELTDCRRQ LADSNIERDKYSGSNKELRDHVKRVESAKREQARAIEEALQKISNLEDTKNSLENERTRLSTILKETENHFTKTTQDLNA TKAQLQ-------------------------------------------------------------------------- ------------------------------------------------------------------------KAQVEFAQ KDEGGKELQCKLVAEVELKERAQQELCQIKKQLSDLEANLCA---TRQELGRARCQNNQEEHRFHARE----------QE LAQRLEEGRGREKRLEDQKHNLEVCLADATQQIQELKARLGGAEGRIRALDEQLSCVELHKR-DTEQKLSSVVHTLRRIA GIQVDGSVNLS------------------------------HRLLSPSRRFSPSRS-------CGDYDNRS--------- ----TSQCPD--------------------------------------------------------------GP---IDV DPDLVRKGVRNLMHQVAQLERE----KDDYKSQLGAAK-KQLQDAADQQLRCDAKLGKLQAMLRNLQEEKSN----LETD RKMKISAIQALEEKLKHRNDECQMLRERLAQTEMQLAATSEENGQNEERLEKSRQQCSK--------------------- ------------LDNEKRQLQEELAKVEGRASKLELQRVAMEGDLTRLQMALQEKDCSIRQMA--ERLENQNRALTQLED RCTALKSTVDQLKERLQKSAVSETQLRGEIKTLQKELSEQGHCSQANE----DKLKLVQKSLQTAENEKRILTERLDSAQ TNLNELRRSQQAQLDGNQRLQEQVTDLEVQRSALESQLRIAKWNQESGGDKDLTNGNGGG-------------------- -------------------------------------------------------------------------------- -----------NGEEELSRQLKSSQREKSELRSKLQTLQDKVKQLECDRKSKFSGGNAYDRAEKSNSFYGGAAESGEFDS NRYDVGGGNAGGGSFNCGLDHSVIEQETRDLRLKVRRLET---------------------------------------- -------------------------------------------------------------------------------- --LLAEKESELARCKARMNDSAKCHDGLDG-------DRYRSAQMHAEKLLDAREQSHRQQVLRLENQ-ISMLREQLAQE AKRRQQYILRSSKANREMQHLRSTLGDSLRNVS-------------------------------QHP-VDPHLLESESRR LDSAVS--MSLPPSSCR------DYDRD---------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Apis_mellifera_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MSRPLPKN ISQLSARG----------------QMERRRPPFLR-----------GPSRMREKIERGIGS------------------- -----------------------------------------------KMDSTG---STLSGTGDCLSEEDLSPDALVRQN YELRHRLEEEAAN----YKRRLDTYRQAQQHQAALVSRLQAKVLQYKQKCSELENQMAESIVYDSN-KVVSSAPPTTSVL DAAHQTLREIREEQIYDLDT--------------------------------------------------------ALKK LSEERKRCEKLLQLNTTLKDQLEESHQTNEALTNDLQKLSNDWDILREELAIKEEEWREEEQAFN---DYYTSEHNRLLI LWRDVVSVKRLFADIKSSTERDLLKMKNNIISTFNDVSSACNNTGFAMRMQAAMHPMISQQVQQ---AQEQVTTDLKTEL ITLKQQYDVAQNEIRIKEEKIN-------QLIRDVHSLEERCGEAETEIHRNTRLQDDIEI------------------- ----------------LQSALRDIAHAVIQDAES-----REIESTQAP---PHLHLSPTGPIPQ---------------- --------KSPKRGTRSNTIPAFAESTISAVQAALHKYQLTIHELQVKLQTNKEQLQNTRKQCENAEENVKTLEKKAEEL II----ELDAVRLHCSQLNQEKDMLQKGLDTIRI----------------------------EKNTLEKTRIELNNMMEN LNNDC----------EKLQKANNKLQKICDNLEDEKLYLQSELNRLSK--DVELRELNLRS-------EEDRCSKMREEL LTLREELNKTYLSKDMLEQQKLETDGLISQIE-KSKGDLELELERVLLEKSDVQEVLMKLETVCSNHEQEKQRLQEELKK -------------------------VTEEKNKLANQCTDQQGDLGSLRKELLQAEQTRLDLESEKVTLNEKVKFLEIEKE KIEIELAQVTRERGDFN---------------------NQLSVLARKKETLNEELMRLKQRLEQANEMNGRINRNLEDLV KDNEEKQVLLETNEKEVQRLQEQLAS-----MRSEK--ETLEGVLFDTQTSLENMHVKKTQLEKEQKELLIKQESLKG-- --QVERLMKDLENSEKRIHEVKQTLTQQSGDQEAEFQ------QIISNVKKHSEENIKK--LNEEKEQIKINLEKRLQQS LLQVTGEKDNEINQL-------------QQRIDEMQQHIENLCQQHEEVLLRAEN------------------------- --------------------------------------------DKQQALLIAHHDQQALMEKLETVLHEMEEEKNNVER VKREAAVKTEQERN-------NINQLRDELNRLKTKLDETRLKTDEEKIKLDLKIEELWKERELAQR------------- ----------------ESEEL-------------QVQLHMTEDKVDS-LQNQLHETIRKLKDAENLNETLRKELVDIRRQ LGDSTYEKEKYNSSNKELREHVKRIESEKREQNRILEESYQKISALEDMKVNVDAERSRLQAQIRDMEKEMLQLQKQLHF TQDELQ-------------------------------------------------------------------------- ------------------------------------------------------------------------KSHQSNAQ AQNDEKELQARLTNETEERERLQLQLHQVKKQLMDVDNSLKV---TRQELGRLRSRADEENERWRVRE----------QE LVVRLEDSRCRERKLEDQKHNLEVCLADASQQIQELKARLGGSEGRVRALDAQLSQLEITKK-EVEQKLSSVGSTLRRIA GIQMDGSVNIP------------------------------FKLLSPSRRWSPARA--------QDHIDSS--------- -------------------------------------------------------------------------RDVILDV DPEIIRKGVRSLMQQVAQIERE----RDDYKTELCNLK-KQLDENQEIQNRSDIQINTLLTNIRMLQDEKNS----LEVK LSQKQSGYEMQ-------SEECEQLREKIINLELMISNNSEEKIQFEEKLDKLKQVLNK--------------------- ------------VENEKRNLQEELSKSESRATKLELQRMSLEGDLQRLQMMFQEKDANIHKLQ--ERNDTQNRTMTTLEE RCTSLKSMVEQLNLALEKASTTENELKNEINSMQHNIMELTTTLQTSN----EKNKQLQKQISNAENERRILSERIESMQ QSLNDLKHTNQTLTDQITRLQNELANNEVQRCALESQLRIVAYPTQEEN------------------------------- -------------------------------------------------------------------------------- ----------INKDEELLRQLQIAQRERSEMRGKMEALNDKMKLLEADKRNLERQLSLFKSTNRSKS-------YERYEK AHTELLG---------TSFDIDHYEQENRELRLKVRRLET---------------------------------------- -------------------------------------------------------------------------------- --QLAEKEAELIRLKSSYTHTHSVFDFNRDRTG--EIERLRAAQLQAEKLLEAREQSHRQQVLRLENQ-IQLLREQLNQE IKRRQLYVLRSSRAGREMQQLRQALGDSLRTVA-------------------------------QDPSLDAVLLEHEARK LDSTLTSTTSLPPSLALPPPP--SYDRSSTPAQLK--------------------------------------------- -------------------------------------------------------------------------------- ------------------- >Amphimedon_queenslandica_CEP250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEEQETKAPPEEATKDTDSASGDGESKDVRVESTFEELEKEFEEVLQEMVGDGSLGKFKTEYEK--------------- -----------LHKALIKSHESEKRLMLQCQELNAELISNASKVTSALKITQDDKATISSQKQE---------------- ------------------------------IEKLWRAVDDAQDKETKTHETIHQLKLENIS------------------- -------------------------------------------------------------------------------- ----------------LNKLIENGAGFGPAMQESMKALEKEKEELTVERDEQMEEISALRTELSELMEKRKEAENERESV EL-----------KVLQLQEEITAKNQEIDRDSR----------------------------RKAKLEKDLRGVQAEVDN KVEEI-------------KAKQAQLNKAHEDYAKAEQVLKDTQKKYEN--------------------SVKQNEALEVML DKKKKEYDQEVNRNEELARQNSEQIMELKMKE-ESINEFKQEIMKINKIREGLQKKLREIEERKANVEANRDSLMQQIAS -------------------------IEKELEQERRQAESERRSFDELLRERDIISKSLRKSEGSAERLEHLMKMKEQTIK TLQHEITNFKEEAKKQR------------------------SLLLQLEKERDKYGKESTDATQKCLQQMEEVKRKELEML QQKKLIAEAQNKLQQQKTLYEAASSD-----------RSLYSKQLIEARDEITDMKRRIKILSHQIDQLKEEIAAKDG-- ------AMVKVNADLMHLEREKDNLSAEISGRKQELE------AARQLLENQKNEEKKLRKVLTEASTESARQKKELEQV INERDILGTQVIRRN--------------DELSLLYEKIKIQQSTLDKGEIQYKS------------------------- ------------------------------------------------------------------RVEDIRILKLEIKK LRREKGLLTKSVAN--------IEDLKRELCQCQRELLRERTRCKAIEEELENPINIHRWRKLEASD------------- -------------------------------------------------------------------------------- LGTYEMIQKIHTLQKKLIQKTEEVVEKELLIQEKEKLYMDLKQILQRQPGPEVAEQLQIYQQTLKEKTKQMKSMASELNM YETQVA-------------------------------------------------------------------------- ------------------------------------------------------------------------EHKMDIDR LERELQEVKKKYYLQKKKEHIQKERERMLTKGLAPPVIPKAT-----TNMPRFTGGGFNLKPNVLA-------------- -------------------------------------------------------------------------------- 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