>Homo_sapiens_CHRNB2 -------------------------------------------------------------------------------- -----------------------------MARRCGPVAL----------------LLGFGLLRLCSGVWGTDTEERLVEH LLDPSR-YNKL-------------------------------------IRPATNGSEL---------------------- --VTVQLMVSLAQLISV-H------------------------------------------------------------- -----ER-EQIMTTNVWLT------------------------------------------------------------- ----------------------------------------------QEWEDYR-LTWKPEE------------------- --FDN---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE VK-------HFPFDQQNCTMKFRSWTYDRTE----IDLVLKSEV----------------------------ASLDDFT- -PSGEWDIVALPGRRNENPD------------------------DSTYVDITYDFIIRR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT -THT-MAPWVKVVFLE-------------KLPALLFMQQ----------------------------------------- -------------PRHHCARQRLRLRRRQREREG---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------AGA---LFFREAPGADSCTCFVNRASVQG--- ----LAGAFGAEPAPVA--------------------------------------GPGRSGEPCGCGLREAVDGVRFIAD HMRSE-DDDQSVS------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV FGT-IGMFLQP--LFQNYTTTTFLHSDHSAPSSK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Pan_troglodytes_CHRNB2 -------------------------------------------------------------------------------- -----------------------------MARRCGPVAL----------------LLGFGLLRLCSGVWGTDTEERLVEH LLDPSR-YNKL-------------------------------------IRPATNGSEL---------------------- --VTVQLMVSLAQLISV-H------------------------------------------------------------- -----ER-EQIMTTNVWLT------------------------------------------------------------- ----------------------------------------------QEWEDYR-LTWKPEE------------------- --FDN---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE VK-------HFPFDQQNCTMKFRSWTYDRTE----IDLVLKSEV----------------------------ASLDDFT- -PSGEWDIVALPGRRNENPD------------------------DSTYVDITYDFIIRR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT -THT-MAPWVKVVFLE-------------KLPALLFMQQ----------------------------------------- -------------PRHHCARQRLRLRRRQREREG---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------AGA---LFFREAPGADSCTCFVNRASVQG--- ----LAGAFGAEPAPVA--------------------------------------GPGRSGEPCGCGLREAVDGVRFIAD HMRSE-DDDQSVS------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV FGT-IGMFLQP--LFQNYTTTTFLHSDHSAPSSK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Mus_musculus_CHRNB2 -------------------------------------------------------------------------------- -----------------------------MARCSNSMAL----------------LFSFGLLWLCSGVLGTDTEERLVEH LLDPSR-YNKL-------------------------------------IRPATNGSEL---------------------- --VTVQLMVSLAQLISV-H------------------------------------------------------------- -----ER-EQIMTTNVWLT------------------------------------------------------------- ----------------------------------------------QEWEDYR-LTWKPED------------------- --FDN---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE VK-------HFPFDQQNCTMKFRSWTYDRTE----IDLVLKSDV----------------------------ASLDDFT- -PSGEWDIIALPGRRNENPD------------------------DSTYVDITYDFIIRR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT -THT-MAPWVKVVFLE-------------KLPTLLFLQQ----------------------------------------- -------------PRHRCARQRLRLRRRQREREG---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------AGT---LFFREGPAADPCTCFVNPASMQG--- ----LAGAFQAEPA-AA--------------------------------------GLGRSMGPCSCGLREAVDGVRFIAD HMRSE-DDDQSVR------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV FGT-IGMFLQP--LFQNYTATTFLHSDHSAPSSK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Canis_familiaris_CHRNB2 -------------------------------------------------------------------------------- -----------------------------MATRSGPAAL----------------LLGFGLLGLHAGVWGTDTEERLVEH LLDPSR-YNKL-------------------------------------IRPATNGSEL---------------------- --VTVQLMVSLAQLISV-H------------------------------------------------------------- -----ER-EQIMTTNVWLT------------------------------------------------------------- ----------------------------------------------QEWEDYR-LTWKPEE------------------- --FDN---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE VK-------HFPFDQQNCTMKFRSWTYDRTE----IDLVLKSDV----------------------------ASLDDFT- -PSGEWDIVALPGRRNENPD------------------------DSTYVDITYDFIIRR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT -THT-MAPWVKVVFLE-------------KLPTLLFMQQ----------------------------------------- -------------PRHRCARQRLRLRRRQRERE----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------AGA---LLFREAPGES------YSGSARG--- ----GVGTDG-------------------------------------------------------CGLRSAVDGVRFIAD HVRNE-DDDQSVS------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV FGT-IGMFLQP--LFQNYSAATFLHTDHSAPSAK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Xenopus_tropicalis_CHRNB2 -------------------------------------------------------------------------------- -------------------------------------YI----------------SCRDFAFAFGTGCLGTDTEERLVEH LLDPSR-YNKL-------------------------------------IRPATNGSEQ---------------------- --VTVQLMVSLAQLISV-H------------------------------------------------------------- -----ER-EQIMTTNVWLT------------------------------------------------------------- ----------------------------------------------QEWEDYR-LTWDPAE------------------- --FDD---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSHDGSIFWLPPAIYKSACK----IE VK-------HFPFDQQNCTMKFRSWTYDRTE----LDLVLRSDV----------------------------ASLDDFT- -PSGEWDIIALPGRRNENPN------------------------DSTYVDITYDFIIRR--------------------- --------------------KPLFYTINLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT -THT-MPPWVKVVFLD-------------KLPTLLFMKQ----------------------------------------- -------------PRQNCARQRLRQQRQSQER------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------AAGSFFLRD--GARSCTCYVNQASVKKYGA QLSELPEGVNGFRDRQG--------------------------------------KVR----QCLCGLQEAVDGVRFIAD HMKSE-DDDQSVS------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV FGT-IGMFLQP--LFQNYTTNALVHMNHAAKKMK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNB2_a -------------------------------------------------------------------------------- -----------------------------------MMAL----------------WTLFCILAIVKSGYGADTEERLVEH LLNPAH-YNKL-------------------------------------IRPATNGSEV---------------------- --VTVQLMVSLAQLISV-H------------------------------------------------------------- -----ER-EQIMTTNVWLT------------------------------------------------------------- ----------------------------------------------QEWQDYR-LTWSPEE------------------- --FDG---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSVFWLPPAIYKSACK----IE VK-------HFPFDQQNCTLSFRSWTYDRTE----VDLVLRADV----------------------------ASMDDFT- -PSGEWDIIALPGRRNENPS------------------------DPTYVDITYDFIIRR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT -THT-MPPWVKLVFLN-------------KLPALLFMRQ----------------------------------------- -------------PRNSSERQRLRQRRRANEQQEGGRGGLAAGLMAGLG------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------LSGSSSG---------SKENNEACTCYVNRASVKQFG- ------AELGGGGGGGGSTDGLNGIREGGRETREGGANPLQGSALPRGKQQPPTVLTQALLAQACPGFEEAVDGVRFIAN HMKSE-DDDRSVS------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV FGT-IGMFLQP--LFQNYTAKTITHTPG---------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNB2_a -------------------------------------------------------------------------------- -------------------------TAVLPSSLHPSIQA----------------LLFQYAWMVGS-----DTEERLVEH LLNPAH-YNKL-------------------------------------IRPATNGSEL---------------------- --VTVQLMVSLAQLISV-H------------------------------------------------------------- -----ER-EQVMTTNVWLT------------------------------------------------------------- ----------------------------------------------QEWQDYR-LTWIPEE------------------- --FDG---MLKVRLPSKHIWLPDVVLYNN------ADGVYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE VK-------HFPFDQQNCTLRFRSWTYDRTE----IDLVLRADV----------------------------ASMDDFT- -PSGEWDIIALPGRRNENPG------------------------DPTYVDITYDFIIRR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT -THT-MPPWVKMVFLQ-------------KLPALLFMRQ----------------------------------------- -------------PRNSCERQRLRQRRRAQEHKEGG-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------IFGKEDSDPCTCYVNRASVKQFG- ------GDLGGAGG----------------------------------SMDGLNRARDGREAQACPGFEEAVEGVRFIAN HMKSE-DDDQSVS------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV FGT-MGMFMQP--LFQNYTAKTINSSPG---------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNB2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------GLCADTEERLVEH LLNPAH-YNKL-------------------------------------IRPATNGSEL---------------------- --VTVQLMVSLAQLISV-H------------------------------------------------------------- -----ER-EQVMTTNVWLT------------------------------------------------------------- ----------------------------------------------QEWQDYR-LTWIPEE------------------- --FDG---MLKVRLPSKHIWLPDVVLYNN------ADGVYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE VK-------HFPFDQQNCTLRFRSWTYDRTE----IDLVLRADV----------------------------ASMDDFT- -PSGEWDIIALPGRRNENPG------------------------DPTYVDITYDFIIRR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT -THT-MPPWVKMVFLQ-------------KLPALLFMRQ----------------------------------------- -------------PRNSCERQRLRQRRRAQEQKGGGRCGEPGGLMVGNG------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------LGNAGGSGGGTTTGLFGKEDSDPCTCYVNRASVKQFG- ------GDLGSAGGGSMDGL---------NRAREAREGG-SGNQSRGKPGTGAPALSHALLAQACPGFEEAVEGVRFIAN HMKSE-DDDQSVS------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV FGT-MGMFLQP--LFQNYTAKTINSSPG---------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNB2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------GLGADTEERLVEH LLNPAH-YNKL-------------------------------------IRPATNGSEL---------------------- --VTVQLMVSLAQLISV-H------------------------------------------------------------- -----ER-EQVMTTNVWLT------------------------------------------------------------- ----------------------------------------------QEWQDYR-LTWVPEE------------------- --FDG---MLKVRLPSKHIWLPDVVLYNN------ADGVYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE VK-------HFPFDQQNCTLRFRSWTYDRTE----IDLVLRADV----------------------------ASMDDFT- -PSGEWDIIALPGRRNENPA------------------------DPTYVDITYDFIIRR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT -THT-MPPWVKLVFLN-------------KLPALLFMRQ----------------------------------------- -------------PRNSCERQRLRQRRRAQEQKEGGRSGEAGALMVGLG------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------LGNASGNRGGTSTGVFSKEDSDPCTCYVNRASVKQFG- ------GDLA-------------------------------------------------LLAQACPGFEEAVEGVRFIAN HMKSE-DDDQSVS------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV FGT-LGMFMQP--LYQNYT------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Ciona_intestinalis_CHRNB2 -------------------------------------------------------------------------------- ---------------------------------MGSRCW----------------LIAVCLCYVIRECLSAHAEEKLLRH LLDPVR-YNKL-------------------------------------IRPSESITSK---------------------- --VDVHFDLIISQLIGI-N------------------------------------------------------------- -----ER-EQYMITKVWLP------------------------------------------------------------- ----------------------------------------------QVWVDKR-LSWQPMR------------------- --YEN---ITKVQLPSNMIWLPDVVLYNN------ADGMYEVS-----LQSNAIILNNGTVTWMPPAIYKSACK----IK VR-------HFPFDEQNCTMMFRSWTYNRLD----IELKLKNPN----------------------------ATLDDFT- -PSGEWDILQTPGSVNVNPN------------------------DETYQDLLYSLIIRR--------------------- --------------------KPLFYTINLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMMLVTLSIVASVCVLNIHHRSPS -THT-MPPWIRTIFLN-------------HLPPLLGMER----------------------------------------- -------------PGTDDRCRCKVNDATYGVDVT---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------ELSGSDVIRNRKRG----- ----------------------------------------------------------KSEVKLPRDVSSALEGVKFIAD HLRAE-DENKNV-------------------------------------------------------------------- --------------------------------------------------------HEDWKYVAMVIDRMFLFVFVGVCA IGT-IGIFIQP--FV----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Ciona_savignyi_CHRNB2 -------------------------------------------------------------------------------- ------------------------------------------------------------------ECTSAHAEEELLRH LLDSGR-YNKL-------------------------------------IRPSQS-------------------------- -----NFDLIISQLIGI-N------------------------------------------------------------- -----ER-EQFMITKVWLP------------------------------------------------------------- ----------------------------------------------QVWVDER-LSWQPTE------------------- --YEN---ITKVQLPSDMIWLPDIVLYNN------ADGTYEVS-----LQSNAIILNNGTVTWMPPAIYKSACK----IK VR-------HFPFDEQNCTMMFRSWTYDRDD----IELKLMNPN----------------------------ATLDDFT- -PSGEWDILATPGMMNLNAD------------------------DPSYQDLLYSLVIRR--------------------- --------------------KPLFYTVNLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMMLVTFSIIASVCVLNIHHRSPS -THE-MSPWIRRTFLQ-------------VIPPLIGMQR----------------------------------------- -------------PGTDQ---CSYN--KYKVDVS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------DLSGSDVIRKRK------- ----------------------------------------------------------QPEVQLSRDISSALEGVKLISD HLKAE-DRNKNVSFIGYLYILEYLIFRLTRMLIRGYISFIVLLDSPTPAVHVQFRSQGWIRQHLFNLSS----------- ---------------------------------------------------CELVIHEDWKYVAMVIDRMFLFVFVVVCA VGT-VSIFLQP--FV----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Branchiostoma_floridae_CHRNB2 -------------------------------------------------------------------------------- -----------------------------------MLVT----------------KVNVSFCRSHTETLAAEAEERLVQR LFNESR-YNPL-------------------------------------IRPARYNGEK---------------------- --VLVHFRLSISQLINV-D------------------------------------------------------------- -----EK-NQKMKTNVWLH------------------------------------------------------------- ----------------------------------------------QEWFDYR-LSWDPRE------------------- --YDN---IKVIRVPSEIVWRPEIVLFNN------ANGQYDVQ-----LMPKCLIYSGGNITWIPPAIYESACQ----ID VR-------FFPFDQQNCSMKFASWTYDGTE----LDLELKDTN----------------------------AVMDDFK- -KNGEWDILRLPGRKSSHAG------------------------DP-LPYVYFDFILMR--------------------- --------------------RPLFYTINLIIPCILITSLSVLVFYLPSDCG-------------------EKITLS---- ISVLLALTVFLLLI----------------------ADIIPPTSLDVPLIGKYIMFTMIFVTFTIVTTVYILNVHHRHPS -THT-MPPWVRTVFLD-------------KLPRLLLMKR----------------------------------------- --------------PNQCR------KYALRVSESSARN------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------PHEDFPEDHTDSPYYSPRTRPAH--- ------THYKQID------------------------------------------LPPEVPSDLPPELKKAVKNVRYIAD YFRSH-DQDLSIS------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVIDRIFLWTFVSVCF IGT-LGLFLQP--LL----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNG -------------------------------------------------------------------------------M HGGQGPLLLLLLLAVCLGAQGRNQ-------------------------------------------------EERLLAD LMQ---NYDPN-------------------------------------LRPAERDSDV---------------------- --VNVSLKLTLTNLISLNE------------------------------------------------------------- -----R--EEALTTNVWIE------------------------------------------------------------- ----------------------------------------------MQWCDYR-LRWDPRD------------------- --YEG--LWV-LRVPSTMVWRPDIVLENN------VDGVFEVA-----LYCNVLVSPDGCIYWLPPAIFRSACS----IS VT-------YFPFDWQNCSLIFQSQTYSTNE----IDLQLSQEDGQT--------------------IEWIFIDPEAFT- -ENGEWAIQHRPAKMLLDPAA--------------------PAQEAGHQKVVFYLLIQR--------------------- --------------------KPLFYVINIIAPCVLISSVAILIHFLPAK-AGG-----------------QKCTVA---- INVLLAQTVFLFLV----------------------AKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLR-SP HTHS-MARGVR----KVF---------LRLLPQLLRMHVRPLAPAAVQDTQ----------------------------- ----------------SRLQNGSS-GWSITTGEEVAL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------CLPRSELLFQQWQ-RQGLVAAALEK- --------------------------------------------LEKGPELGLSQ-FCGSLKQAAPAIQACVEACNLIAC ARHQQSHFDNGNE------------------------------------------------------------------- ----------------------------------------------------------EWFLVGRVLDRVCFLAMLSLFI CGTAGIFLMAHYNRVPALPFPGDPRPYLPSPD------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gorilla_gorilla_CHRNG -------------------------------------------------------------------------------M HGGQGPLLLLLLLAVCLGAQGRNQ-------------------------------------------------EERLLAD LMQ---NYDPN-------------------------------------LRPAERDSDV---------------------- --VNVSLKLTLTNLISLNE------------------------------------------------------------- -----R--EEALTTNVWIE------------------------------------------------------------- ----------------------------------------------MQWCDYR-LRWDPRD------------------- --YEG--LWV-LRVPSTMVWRPDIVLENN------VDGVFEVA-----LYCNVLVSPDGCIYWLPPAIFRSACS----IS VT-------YFPFDWQNCSLIFQSQTYSTNE----IDLQLSQEDGQT--------------------IEWIFIDPEAFT- -ENGEWAIQHRPAKMLLDPAA--------------------PAQEAGHQKVVFYLLIQR--------------------- --------------------KPLFYVINIIAPCVLISSVAILIYFLPAK-AGG-----------------QKCTVA---- INVLLAQTVFLFLV----------------------AKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLR-SP HTHS-MARGVR----KVF---------LRLLPQLLRMHVRPLAPAAVQDTQ----------------------------- ----------------SRLQNGSS-GRSITTGEEVAL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------CLPRSELLFQQWQ-RQGLVAAALEK- --------------------------------------------LEKGPELGPSQ-FCGSLKQAAPAIQACVEACNLIAC ARHQQSHFDNGNE------------------------------------------------------------------- ----------------------------------------------------------EWFLVGRVLDRVCFLAMLSLFV CGTAGIFLMAHYNRVPALPFPGDPHPYLPSPD------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Mus_musculus_CHRNG -------------------------------------------------------------------------------M QGGQRPQLLLLLLAVCLGAQSRNQ-------------------------------------------------EERLLAD LMR---NYDPH-------------------------------------LRPAERDSDV---------------------- --VNVSLKLTLTNLISLNE------------------------------------------------------------- -----R--EEALTTNVWIE------------------------------------------------------------- ----------------------------------------------MQWCDYR-LRWDPKD------------------- --YEG--LWI-LRVPSTMVWRPDIVLENN------VDGVFEVA-----LYCNVLVSPDGCIYWLPPAIFRSSCS----IS VT-------YFPFDWQNCSLVFQSQTYSTSE----INLQLSQEDGQA--------------------IEWIFIDPEAFT- -ENGEWAIRHRPAKMLLDSVA--------------------PAEEAGHQKVVFYLLIQR--------------------- --------------------KPLFYVINIIAPCVLISSVAILIYFLPAK-AGG-----------------QKCTVA---- TNVLLAQTVFLFLV----------------------AKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLR-SP HTHS-MARGVR----KVF---------LRLLPQLLRMHVRPLAPAAVQDAR----------------------------- ----------------FRLQNGSSSGWPIMAREEGDL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------CLPRSELLFRQRQ-RNGLVQAVLEK- --------------------------------------------LENGPEVRQSQEFCGSLKQASPAIQACVDACNLMAR ARRQQSHFDSGNE------------------------------------------------------------------- ----------------------------------------------------------EWLLVGRVLDRVCFLAMLSLFI CGTAGIFLMAHYNQVPDLPFPGDPRPYLPLPD------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Xenopus_tropicalis_CHRNG -------------------------------------------------------------------------------- -RGGMDTVLLLVLICISAALCHNE-------------------------------------------------EEGLLND LMK---NYNKN-------------------------------------LRPAEKDGDI---------------------- --VSVSIKLTLTNLISLNE------------------------------------------------------------- -----R--EEALTTNVWVE------------------------------------------------------------- ----------------------------------------------VQWRDYR-LSWDPNE------------------- --YYG--ISM-MRIPSTSVWLPDVGLENN------VDGTFDIA-----LYANTLVSSDGSMYWLPPAIYRSSCP----VV VT-------YFPFDWQNCSMVFQSQTYSANE----IELLLTVDE-QT--------------------IEWIEIDPEAFT- -ENGEWAIKHMPAKKIIN-HRL-------------------TPDDLNYQQIVFYLIIQR--------------------- --------------------KPLFYIINIIVPCVLISFVSILVYFLPAK-AGG-----------------QKCTVS---- INILLAQTVFLFLI----------------------AQKIPETSTAVPLIVKYLTFLMVVTITIVANAVIVLNISLR-TP NTHS-MSSTVR----ELC---------LRTVPRLLRMHLR--PSDAAPP------------------------------- ---------------LAPLMRRSSSVGLMIKADEYML------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------RKPRSQLMFEKQKERDGLMKVVLDK- --------------------------------------------IGRGMENNTSDDLVHSLKHAAPEIRACVEACCHIAS ATREKNEFKSTGDN------------------------------------------------------------------ ----------------------------------------------------------DWKCQSKVL------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNG_a ------------------------------------------------------------------------------MD QNLSSKIIWLWILLFRFSGALCNL-------------------------------------------------EGSLHRD LMV---GYNKN-------------------------------------IRPVESHEDI---------------------- --IDVKIKMTLTNLISLNE------------------------------------------------------------- -----K--EETLTTCVWIE------------------------------------------------------------- ----------------------------------------------MQWRDYR-LRWANRTGFE---------------- -VYEN--ITR-MRLPSKTIWLPDIGLENN------VDGRFEVA-----LYANTLIDPDGSVYWLPPAIYRSSCA----IK VN-------YFPFDWQNCSMVFRSQTYNSNE----ITLMLSDEDNVT--------------------MEWIEIDPEAFT- -ENGEWMIKHRPAKKVIN-KRY-------------------RPDELEHQEIIFFLIIQR--------------------- --------------------KPLFYVINIIVPCVLFSSLGLLVYFLPAK-AGG-----------------QKCTMT---- ICILLGQTVFLFLI----------------------AKKVPETSQAVPLIGKYLMFVMSVTTITVMNCVVVLNVSLR-TP NTHP-MSNTIR----KVL---------LNILPRVLRMTMQRWTPEQEEGDFKMFAL------------------------ ------------GNGTPLRRRRRSSLGLIAKADEYMF------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------RTARSELMFSRLKERKGLLKNTLEK- --------------------------------------------IQNGLGGNTAQDLECSLAAASPEVQQCVSSCKHIAE STKHQNDFQSKNE------------------------------------------------------------------- ----------------------------------------------------------EWFLVARVIDRMCFFVMALLFI LGTIGIFLTGHFNQAPSQPFPGDPKKYLPEISAGDIPG------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNG_a -----------------------------------------------------------------------------MDS GCPLSLSLFIRVFMISAAASAVNL-------------------------------------------------EGELFKD LMK---GYNKN-------------------------------------VRPTEKSGDI---------------------- --TQVDIKLTLTNLISLNE------------------------------------------------------------- -----K--EEALTTSVWIE------------------------------------------------------------- ----------------------------------------------LQWCDYR-LRWDQPPRST---------------- -LYGN--ITKPLRIPSKILWLPDIILENN------VDGQFEVA-----LYCNALVSPDGCVYWLPPAIYRSACP----IT VN-------YFPFDWQNCTMVFRSQTYSANE----IDMVLKVEDNHT--------------------LEWVDIDPEAFT- -ENGEWAIKHRPAKKVIN-SQY-------------------TKDDREYQEVIFFLIIQR--------------------- --------------------KPLFYIINIIAPCVLFSSLCLLVYYLPAK-AGG-----------------QKCTMS---- VATLLGQTVFLFLI----------------------AKKVPETSKAVPLIAKYLMFVMSVTTMVVMNCVIVLNVSLR-TP STHI-MTDAVR----KVL---------LNILPRLLKMQMRPWTPNNDST------------------------------- ---------------PEIRNRRRSSMTLITKAEEYAM------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KTARSELMFSRLKERNGLMKSVLEK- --------------------------------------------LHDGLDGGTPEQLGISLAKASPEVKKCVASCKHIAE TARQQSNFQNENE------------------------------------------------------------------- ----------------------------------------------------------EWFLVARVIDRACFIVMASVFF IGTIGVFLMGHFNQPPSAPFPRDAKTYLPPIN------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNG_a -------------------------------------------------------------------------------S GCRLSLSFFVTVFTISAAASAVNL-------------------------------------------------ERELFKD LMK---GYNKH-------------------------------------VRPTEKSGDI---------------------- --TQVDIKMTLTNLISLNE------------------------------------------------------------- -----K--EEALTTSVWIE------------------------------------------------------------- ----------------------------------------------LQWCDYR-LRWDQPPRAA---------------- -LYGN--ITKPLRIPSRIIWLPDIILENN------VDGQFEVA-----LYCNALVSPDGCVYWLPPAIYRSACP----IT VN-------YFPFDWQNCTMVFRSQTYSANE----INMVLKVEDNHT--------------------LEWVDIDPEAFT- -ENGEWAIKHRPAKKVIN-RQY-------------------TKDDQEYQEVIFFLIIQR--------------------- --------------------KPLFYIINIIVPCVLFSSLCLLVYYLPAK-AGG-----------------QKCTMS---- IATLLGQTVFLFLI----------------------AKKVPETSKAMPLIAKYLMFVMSVTTMVVMNCVIVLNVSLR-TP STHI-MTDTVR----KIL---------LNILPRLLKMRMRPWTPNKDS-------------------------------- ----------------AFPCRRRSSMTLITKAEEYVM------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KTARSELMFSRLKERNGLMKSVLEK- --------------------------------------------LHEGLDGGTPEQLSISLAKASPEVKKCVASCKHIAE TARQHNNFQNENE------------------------------------------------------------------- ----------------------------------------------------------EWFLVARVIDRVCFIVMASVFF IGTMGVFLMGHFNQPPSTPFPGDVKMYLPP-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNG_a -------------------------------------------------------------------------------- -----VIHILTIFICIEKTSAINL-------------------------------------------------EGELFKD LMK---GYNKN-------------------------------------VRPMENGSDV---------------------- --TQVAIKMTLTNLISLNE------------------------------------------------------------- -----K--EEALTTGVWIG------------------------------------------------------------- ----------------------------------------------MQWCDYR-LRWDRPPRSA---------------- -LYGS--ITSQLRLPSKSIWLPDIILENN------VDGNFEVA-----LYCNALVSPNGCVNWLPPAIYRSACA----IT VN-------YFPFDWQNCTMVFHSQTYSANE----IKLVLTEEDDLT--------------------LEWVDIDPEAFT- -ENGEWAIKHRPAKKLIN-TDY-------------------NKDELEYQEVVFFLIIQR--------------------- --------------------KPLFYVINIIAPCVLFSSLGLLVYFLPAK-AGG-----------------QKCTMS---- IATLLGQTVFLFLI----------------------AKKVPETSRAVPLIGKYLMFVMSVTTMVVMNCVIVLNVSLR-TP NTHK-MTDKVR----KIL---------LNILPRLLNMQMRPWTPDGDN-------------------------------- -----------------ADTRRRSSMTLITKAEEYAM------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KTARSELMFAALKERNGLMRSVLEK- --------------------------------------------LKDELEGGTAEQLSASLGKASSQLQQCVSSCKHIAK TARQQNNFKKENE------------------------------------------------------------------- ----------------------------------------------------------EWFLVAKVIDRVCFIVMVSVFF IGTIGIFLTGHFNQPPSSPFLGDPKTYLPPTNNLTDRVENGR-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRND -----------------------------------------------------------------------------MEG PVLTLGLLAALAVC---GSWGLNE-------------------------------------------------EERLIRH LFQE-KGYNKE-------------------------------------LRPVAHKEES---------------------- --VDVALALTLSNLISLKE------------------------------------------------------------- -----V--EETLTTNVWIE------------------------------------------------------------- ----------------------------------------------HGWTDNR-LKWNAEE------------------- --FGN---ISVLRLPPDMVWLPEIVLENN------NDGSFQIS-----YSCNVLVYHYGFVYWLPPAIFRSSCP----IS VT-------YFPFDWQNCSLKFSSLKYTAKE----ITLSLKQDA----------------KENRTYPVEWIIIDPEGFT- -ENGEWEIVHRPARVNVDP-RA-------------------PLDSPSRQDITFYLIIRR--------------------- --------------------KPLFYIINILVPCVLISFMVNLVFYLPAD---S----------------GEKTSVA---- ISVLLAQSVFLLLI----------------------SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFR-TP STHV-LSEGVKKLF-------------LETLPELLHMSRPAEDGPSPG--A----------------------------- ------------------LVRRSSSLGYISKAEEYFL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------LKSRSDLMFEKQSERHGLARRLT--- ------------------------------------------------TARRPPASSEQAQQELFNELKPAVDGANFIVN HMRDQNNYNEEKD------------------------------------------------------------------- ----------------------------------------------------------SWNRVARTVDRLCLFVVTPVMV VGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Mus_musculus_CHRND -----------------------------------------------------------------------------MAG PVLTLGLLAALVVCALPGSWGLNE-------------------------------------------------EQRLIQH LFNE-KGYDKD-------------------------------------LRPVARKEDK---------------------- --VDVALSLTLSNLISLKE------------------------------------------------------------- -----V--EETLTTNVWID------------------------------------------------------------- ----------------------------------------------HAWVDSR-LQWDAND------------------- --FGN---ITVLRLPPDMVWLPEIVLENN------NDGSFQIS-----YACNVLVYDSGYVTWLPPAIFRSSCP----IS VT-------YFPFDWQNCSLKFSSLKYTAKE----ITLSLKQEE----------------ENNRSYPIEWIIIDPEGFT- -ENGEWEIVHRAAKLNVDP-SV-------------------PMDSTNHQDVTFYLIIRR--------------------- --------------------KPLFYIINILVPCVLISFMINLVFYLPGD---C----------------GEKTSVA---- ISVLLAQSVFLLLI----------------------SKRLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFR-TP STHV-LSEGVKKFF-------------LETLPKLLHMSRPAEEDPGPR--A----------------------------- ------------------LIRRSSSLGYICKAEEYFS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------LKSRSDLMFEKQSERHGLARRLT--- ------------------------------------------------TARRPPASSEQVQQELFNEMKPAVDGANFIVN HMRDQNSYNEEKD------------------------------------------------------------------- ----------------------------------------------------------NWNQVARTVDRLCLFVVTPVMV VGTAWIFLQGVYNQPPLQPFPGDPFSYSEQDKRFI--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Felis_catus_CHRND -------------------------------------------------TARTPSWGVAGSPQLSPAPWPGRISRQPPSR SPLPAPHPSSCPSP---GSWGLNE-------------------------------------------------EERLIRH LFEE-KGYNKE-------------------------------------LRPVAHKDES---------------------- --VEVSLALTLSNLISLKE------------------------------------------------------------- -----V--EETLTTNVWME------------------------------------------------------------- ----------------------------------------------HGWTDPR-LQWDAEE------------------- --FGN---ISVLRLPPDMLWLPEIVLENN------NDGSFQIS-----YACNVLVYPSGYVYWLPPAIFRSSCP----IS VT-------YFPFDWQNCSLKFSSLKYTAKE----ITLSLKQEE----------------KEGRSYPVEWIVIDPAGFT- -ENGEWEIVHRPARINVDP-SV-------------------PLDSPGHQDVTFYLIIRR--------------------- --------------------KPLFYIINILVPCVLISFMINLVFYLPAD---S----------------GEKTSMA---- ISVLLAQSVFLLLI----------------------SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFR-TP STHV-LSEGVKKLF-------------LETLPKRLHMSRPAEDGPSPG--A----------------------------- ------------------LVRRSSSLGYISKAEEYFL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------LKSRSDLMFEKQSERHGLARRLT--- ------------------------------------------------TARRPPAGSEQAQQELFSQLKPAVDGANFIVN HMRDQNNYNEEKD------------------------------------------------------------------- ----------------------------------------------------------CWNRVARTVDRLCLFVVTPIMV VGTAWIFLQGAYNQPPPQPFPGDPFSYHEKDKRFA--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Xenopus_tropicalis_CHRND ------------------------------------------------------------------------------HA WLWLFDLLCILVLVP--GCLSESE-------------------------------------------------EERLLNH IFGE-RGYRKE-------------------------------------LRPVEHTGET---------------------- --VNVSLALTLSNLISLKE------------------------------------------------------------- -----A--DETLTTNVWVE------------------------------------------------------------- ----------------------------------------------LGWYDKR-LAWDMEE------------------- --FHH---INIIRVPPDMVWQPQLILENN------NNGVFEVA-----YYSNVLVNSDGFMYWLPPAIFQTSCS----IN VN-------YFPFDWQNCSLKFSSLTYNAKE----INLQLRQDQDE----ESQR-----N-----YPVEWIIIDPEGFT- -ENGEWEIVHIPAKKNIDR-SL-------------------TPESTKYQDITFYLIIKR--------------------- --------------------KPLFYIINILAPCVLIALMANLVFYLPAD---S----------------GEKMTLA---- ISVLLAQSVFLLLI----------------------SQRLPETSFAIPLISKYLMFIMVLVTIVVVSCVIVLNLHFR-TP STHV-ITERMKEIF-------------LNKLPRILHMSRPAEPEPEPWSGV----------------------------- ------------------LLRRSSSVGYIVKAEEYYS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------VKSRSELMFEKQSERHGLTSRAT--- ------------------------------------------------PARVNPLNSNNSQDQLYGEIKPAIDGANFIVK HMRDKNDYNEEKD------------------------------------------------------------------- ----------------------------------------------------------NWYRIARTVDRLCLFLVTPVMI IGTLWIFLGGAYNLPPSLPFPGDPFDYNKEHKRLI--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRND_a ------------------------------------------------------------------------ARGCNLSR GRNSAMHLRVCVCVS--GCWCRNE-------------------------------------------------EERLIHH LFKE-LGYNKE-------------------------------------LRPVRRHEDA---------------------- --VDVQLALTLSNLISLKE------------------------------------------------------------- -----V--DETLLTNVWIE------------------------------------------------------------- ----------------------------------------------HTWTDYR-LSWNLSA------------------- --FDG---ISMLRLPSNMVWLPEIVLENN------NDAQFKVA-----YYSNVLVSSDGLCYWLPPAIFRSSCS----IS VK-------YFPFDWQNCTLKFTSLTYNAKE----IRMLLKEDALN----------------GTAYTVEWIVIDPASFT- -ENGEWEIIHRPAKRNTYK-HI-------------------PMESNKHQDITFYLVIRR--------------------- --------------------KPLFYVVNIIIPCVLISFLALLVYYLPAD---S----------------GEKMTLS---- ISVLLAQSVFLLLI----------------------SQRLPETSMSVPLIVKYLMFIMVGVTVVVLNCVVVLNLHFR-TP STHV-MSGWTKRLF-------------LERLPRLLRMSRPAETEA-YWDGV----------------------------- ------------------LPRRSSSVGYIASAEEYYS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------VKSRSELMFEKQSERHGLVTRVT--- ------------------------------------------------HAAMKPQDEGGVTDQLYAEIKPAVDGANYIIK HMRNKNDYNEEKD------------------------------------------------------------------- ----------------------------------------------------------NWSGIARTVDRLCLFLVTPLMT VGTVIIFTGI-CNQPPHLPFKGDPHDYREENPRLL--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRND_b -------------------------------------------------------------------------------- -----------------GCWCRNE-------------------------------------------------EERLIHH LFKE-LGYNKE-------------------------------------LRPVRRHEDA---------------------- --VDVQLALTLSNLISLKE------------------------------------------------------------- -----V--DETLLTNVWIE------------------------------------------------------------- ----------------------------------------------HTWTDYR-LSWNLSA------------------- --FDG---ISMLRLPSNMVWLPEIVLENN------NDAQFKVA-----YYSNVLVSSDGLCYWLPPAIFRSSCS----IS VK-------YFPFDWQNCTLKFTSLTYNAKE----IRMLLKEDALN----------------GTAYTVEWIVIDPASFT- -ENGEWEIIHRPAKRNTYK-HI-------------------PMESNKHQDITFYLVIRR--------------------- --------------------KPLFYVVNIIIPCVLISFLALLVYYLPAD---S----------------GEKMTLS---- ISVLLAQSVFLLLI----------------------SQRLQKH--PCLFLSSYLMFIMVGVTVVVLNCVVVLNLHFR-TP STHV-MSGWTKRLF-------------LERLPRLLRMSRPAETEA-YWDGV----------------------------- ------------------LPRRSSSVGYIASAEEYYS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------VKSRSELMFEKQSERHGLVTRGR--- ------------------------------------------------SDRSAVRRD-----------QAGCGRSNYIIK HMRNKNDYNEEKD------------------------------------------------------------------- ----------------------------------------------------------NWSGIARTVDRLCLFLVTPLMT VGTVIIFTGI-CNQPPHLPFKGDPHDYREENPRLL--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Ciona_savignyi_CHRND -------------------------------------------------------------------------------- -------LHTGFILLVLAASAASV------------------------------------------LSEFQSSESRLMKR LLNG---YNNQ-------------------------------------FRPYNVEYENK--------------------- --TLVSMGMTLSQIISVK-------------------------------------------------------------- -----EK-SQELTTSVYMT------------------------------------------------------------- ----------------------------------------------FDW-VDNRFSWDPEE------------------- --YEG---ITIIRIPPYAIWSPRIVLQNS------IDGNFDVS-----VPVMALIKYTGEVQWIPPGLYKSTCT----IV VA-------LFPFDWQNCTMVFRSATYDRSE----MEFGLSYGDSIYVDPEA-------------------------FK- -ENGEWKIVQRPVRINSDSS------------------------DPTYQDVTFYLIIRR--------------------- --------------------KPQFYVINLIIPCILMSSLSCFVFYLPSVSC-------------------EKMTLS---- ISVLLGETVFLFLI----------------------AQRVPETSLAVPLIAGYLLFVMILVIISVISSVVVCNVHYRSNT --THSMPDWVVWFFME-------------KLAPILRVERPSEEESGACSARPR----RCSSVS----------------- ------------ARKAMRQRKEWKS-PSEIMFDHQAS------------------------------------------- -----------------------------------------------------------------------------RLG FRR----------------------------------------------------------------------------- ----------------------------------------------------------RHVVNHYGMTEVNVASPEND-- -------------------------------------------------------------------FEPAAESINYIAN QLKEENDSA----------------------------------------------------------------------- ------------------------------------------------------QSKDDWGYVALILDRILLWIYFAAFS LGT-LFFFLQSTFAYYPEQ------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Caenorhabditis_elegans_CHRND -------------------------------------------------------------------------------- MRTNRLSWILVLSVVIFLVIIN--------------------------------------------TINASDDEERLMVD VFRG---YNSL-------------------------------------IQPVRNSSELP--------------------- --LIVKMALQLVLLINVD-------------------------------------------------------------- -----EK-DQVMHTNVWLT------------------------------------------------------------- ----------------------------------------------LQWHDFQ-MKWNPVN------------------- --YGE---IKQIRVSPDKVWLPDIVLFNN------ADGNYEVS-----FMCNVVINHKGDMLWVPPAIYKSSCI----ID VE-------FFPFDEQVCTLVFGSWTYNENE----IKLEFVQ-AE--------------------------LVDVSEYS- -ASSIWDVIDVPASLVNKRSR-----------------------------IEFQVRIRR--------------------- --------------------KTLFYTVVLIIPTVLMAFLSMAVFFLPTDSG-------------------EKITLT---- ISVLLSIVVFLLLV----------------------SKILPPTSSTIPLMAKYLLLTFVLNVITILVTVIIINVYFRGPR -THR-MPQWVRVVFLQ-------------FLPKLVCMKRPKSASERSAVRSG---------------------------- ------------MAQLP-------GVGQFTLSP----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------SAHHPLCPSADDRTTT--- -------------------------------------------------IRNTASNETSAYYPLSTDALRAIDAIEYITE HLKRDEQ------------------------------------------------------------------------- ----------------------------------------------------HKSFRDDWKYVAMIIDRLLLYVFFGITV GGT-CGILFSAPHVFQRIDQQEMLDRLKEKYDTASNIP------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNA1 -------------------------------------------------------------------------------- -----MEPWPLLLLFSLCSAG---------------------------------------------LVLGSEHETRLVAK LFKD---YSSV-------------------------------------VRPVEDHRQV---------------------- --VEVTVGLQLIQLINVD-------------------------------------------------------------- -----EV-NQIVTTNVRLKQGDMVDLPRPSCV------------------------------------------------ ----------------------------------TLGVPLFSHLQNEQWVDYN-LKWNPDD------------------- --YGG---VKKIHIPSEKIWRPDLVLYNN------ADGDFAIV-----KFTKVLLQYTGHITWTPPAIFKSYCE----II VT-------HFPFDEQNCSMKLGTWTYDGSV----VAINPESDQ----------------------------PDLSNFM- -ESGEWVIKESRGWKHSVTYSC--------------------CPDTPYLDITYHFVMQR--------------------- --------------------LPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS -THV-MPNWVRKVFID-------------TIPNIMFFST----------------------------------------- ----------------------MKRPSREKQDKK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------IFTEDIDISDISGKPGPPPMGFHS--- ------------------------------------------------------------PLIKHPEVKSAIEGIKYIAE TMKSDQE------------------------------------------------------------------------- ----------------------------------------------------SNNAAAEWKYVAMVMDHILLGVFMLVCI IGT-LAVFAGRLIELNQQG------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Pan_troglodytes_CHRNA1 -------------------------------------------------------------------------------- -----MEPWPLLLLFSFCSAG---------------------------------------------LVLGSEHETRLVAK LFKD---YSSV-------------------------------------VRPVEDHRQV---------------------- --VEVTVGLQLIQLINVD-------------------------------------------------------------- -----EV-NQIVTTNVRLKQGDMVDLPRPSCV------------------------------------------------ ----------------------------------ILGVPLFSHLQNEQWVDYN-LKWNPDD------------------- --YGG---VKKIHIPSEKIWRPDLVLYNN------ADGDFAIV-----KFTKVLLEYTGHITWTPPAIFKSYCE----II VT-------HFPFDEQNCSMKLGTWTYDGSV----VAINPESDQ----------------------------PDLSNFM- -ESGEWVIKESRGWKHSVTYSC--------------------CPDTPYLDITYHFVMQR--------------------- --------------------LPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIIINTHHRSPS -THV-MPNWVRKVFID-------------TIPNIMFFST----------------------------------------- ----------------------MKRPSREKQDKK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------IFTEDIDISDISGKPGPPPMGFHS--- ------------------------------------------------------------PLIKHPEVKSAIEGIKSTTV TMKSDQE------------------------------------------------------------------------- ----------------------------------------------------SNYAAAEWKYVAMVMDHILLGVFMLVCI IGT-LAVFAGRLIELNQQG------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Felis_catus_CHRNA1 ------------------------------------------------------------------------------MR VFVEGGEQNLTVCVSFAVSAG---------------------------------------------LVLGSEHETRLVAK LFED---YNSV-------------------------------------VRPVEDHRQA---------------------- --VEVTVGLQLIQLINVD-------------------------------------------------------------- -----EV-NQIVTTNVRLKQ------------------------------------------------------------ -----------------------------------------------QWVDYN-LKWNPED------------------- --YGG---VKKIHVPSEKIWRPDFVLYNN------ADGDFAIV-----KFTKVLLDYTGHITWTPPAIFKSYCE----II VT-------HFPFDEQNCSMKLGTWTYDGSV----VAINPESDQ----------------------------PDLSNFM- -ESGEWVIKESRGWKHWVFYAC--------------------CPTTPYLDITYHFVMQR--------------------- --------------------LPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS -THV-MPNWVRKVFID-------------TIPNIMFFST----------------------------------------- ----------------------MKRPSREKQDKK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------IFTEDIDISDISGKPGPPPMGFHS--- ------------------------------------------------------------PLIKHPEVKSAIEGVKYIAE TMKSDQE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKYVAMVMDHILLGVFMLVCI IGT-LAVFAERMKTMVRITPPAPQS------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Anolis_carolinensis_CHRNA1 -------------------------------------------------------------------------------- -----MDVCCLPLLLLLGPAV---------------------------------------------LVRCSSHETRLVSD LFSK---YNKV-------------------------------------VRPVSNHRDP---------------------- --VRVTVGLQLIQLINVD-------------------------------------------------------------- -----EV-NQIVTTNVRLKQ------------------------------------------------------------ -----------------------------------------------QWMDVN-LKWNPED------------------- --YGG---VKQIRIPSEDIWRPDLVLYNN------ADGDFAIN-----KFTKILLNYTGHITWTPPAIFKSYCE----II VT-------HFPFDEQNCSMKLGTWTYDGTM----VVINPESDR----------------------------PDLSNYM- -GSGEWIMKDYRGWKHEVTYAC--------------------CPDLPYLDITYHFVMLR--------------------- --------------------LPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRNPS -THT-MPQWVRKIFID-------------TIPNLMFFST----------------------------------------- ----------------------MKRPSKNKQEKK---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------IFSEDIDISEISGKQGPATVNFQS--- ------------------------------------------------------------SLIKNPEVKSAIEGIKYIAE TMKSDQE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKFVAMVVDHLLLGIFMSVCI IGT-LAVFAGRLIELHQQG------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNA1_a -------------------------------------------------------------------------------- ------MNYFILILPILPYLYG--------------------------------------------PAVCSEDETRLVKT LFTG---YNKV-------------------------------------VRPVSHFKDP---------------------- --VVVTVGLQLIQLISVD-------------------------------------------------------------- -----EV-NQIVTSNVRLKQ------------------------------------------------------------ -----------------------------------------------QWKDVH-LQWNPDD------------------- --YGG---IRKIRIPSTDLWKPDLVLYNN------ADGDFAIV-----HETKVLLEHTGMITWTPPAIFKSYCE----IV VL-------HFPFDLQNCSMKLGTWTYDGNL----VIINPDSDR----------------------------PDLSNFM- -ESGEWVMKDYRSWKHWVYYAC--------------------CPDTPYLDITYHFLLLR--------------------- --------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMIFVIASIIITVIVINTHHRSPS -THI-MPAWVRKIFID-------------TIPNMMFFST----------------------------------------- ----------------------MKRPSQERQEKR---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------LFPADFDISDISGKPMPASVTYHS--- ------------------------------------------------------------PITKNPDVRSAIEGVKYIAD TMKSDEE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCI IGT-LGVFAGRLIELSML-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNA1_a -------------------------------------------------------------------------------- --------LHLCDFSSGVETLA--------------------------------------------GTCASEDETRLVKT LFTG---YNKV-------------------------------------VRPVNHFSEP---------------------- --VVVTVGLQLIQLISVD-------------------------------------------------------------- -----EV-NQIVTSNVRLRQ------------------------------------------------------------ -----------------------------------------------QWVDVN-LNWNPDD------------------- --YGG---IRKIRVPSTDIWKPDLVLYNN------ADGDFAII-----HETKVLLEHTGKIIWNPPAIFKSYCE----II VL-------HFPFDLQNCSMKLGTWTYDGLL----VVINPDSDR----------------------------PDLSNFM- -ESGEWVLKDYRSWKHWVYYTC--------------------CPDTPYLDITYHFLMLR--------------------- --------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS -THT-MPPWIRKVFIE-------------TIPNMMFFST----------------------------------------- ----------------------MKRPSQEIRQKR---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------LFPTDMDISDISGNPTPTSVTYQS--- ------------------------------------------------------------PIVKNPDVRSAIEGVKYIAE TMKSDEE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCI IGT-LAVFAGRLIELN---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNA1_a ---------------------------------------------------------------------------FTLRV SGGSLWFRAHLPERSQHFSRSP---------------------------------------------VLCSEDETRLVKT LFTG---YNKV-------------------------------------VRPVNHFSEP---------------------- --VVVTVGLQLIQLINVD-------------------------------------------------------------- -----EV-SQIVTSNVRLRQ------------------------------------------------------------ -----------------------------------------------QWVDVN-LNWNPDD------------------- --YGG---IRKIRVPSSEIWKPDLVLYNN------ADGDFAII-----HETKVLLEHTGKIIWNPPAIFKSYCE----II VL-------HFPFDVQNCSMKLGTWTYDGLL----VVINPDSDR----------------------------PDLSNFM- -ESGEWVLKDYRSWKHWVYYTC--------------------CGDTPYLDITYHFLMQR--------------------- --------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS -THT-MPPWIRKVFIE-------------TIPNMMFFST----------------------------------------- ----------------------MKCPSQEIRQKR---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------LFPTDMDISDISGNPTPTSVTYQS--- ------------------------------------------------------------PIVKNPDVRSAIEGVKYIAE TMKADEE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCI IGT-VAVFAGRLIELNMP-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNA1_b -------------------------------------------------------------------------------- ------MNTTLFSFHII-LLAG--------------------------------------------AAWASSNETRLVKN LFAG---YNKV-------------------------------------VRPVTHFKDP---------------------- --VVVTVGLQLIQLINVD-------------------------------------------------------------- -----EV-NQIVSSNVRLKQ------------------------------------------------------------ -----------------------------------------------QWKDVN-LHWNPDD------------------- --YGG---IKKIRVPSTDIWRPDLVLYNN------ADGDFAIV-----HETKVLLEHTGMITWNPPAIFKSYCE----II VL-------HFPFDLQNCSMKLGTWTYDGNL----VVVNPDSDR----------------------------PDLSNFM- -ESGEWVMKDYRGWKHWVYYAC--------------------CPDTPYLDITYHFLMLR--------------------- --------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS -THT-MPDWVRRIFIE-------------TIPNIMFFST----------------------------------------- ----------------------MKRPGKEKQRKG---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------IQPPDFDISEISGN-QATAVPYET--- ------------------------------------------------------------RITKNPDVRSAIEGVKYIAE TMKSDEE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCL VGT-LGVFAGRLIELSML-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNA1_a -------------------------------------------------------------------------------- ---------------------P---------------------------------------------VSCSEAETRLVKK LFTG---YSKV-------------------------------------VRPVDHFSDA---------------------- --VVVSVGLQLIQLISVD-------------------------------------------------------------- -----EV-NQIVTSNVRLKQ------------------------------------------------------------ -----------------------------------------------RWRDVN-LNWDPDD------------------- --YGG---IRKIRVPSTDIWKPDLVLYNN------ADGDFAII-----HQTKVLLEHTGMITWNPPAIFKSYCE----II VL-------HFPFDLQNCSMKLGTWTYDGLL----VVINPDSAR----------------------------PDLSNFM- -ESGEWVLKDYRSWKHTVNYSC--------------------CPNKPYLDITYHFLMLR--------------------- --------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS -THT-MPAWIRKVFIE-------------TIPNMMFFST----------------------------------------- ----------------------MKRPSLEIRQMR---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MFPTDMDISDISGNPAPTSDTYVS--- ------------------------------------------------------------PITKNPDVRRAIEGVKYIAE TMKSDEE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCI IGT-LAVFAGRLIELNTL-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNA1_b -------------------------------------------------------------------------------- ---MARMKPVFFIFYLV-ILAG--------------------------------------------AAWGSSDETRLVKT LFTG---YNKV-------------------------------------VRPVNHFKDP---------------------- --VVVTVGLQLIQLISVD-------------------------------------------------------------- -----EV-NQIVSSNVRLKQ------------------------------------------------------------ -----------------------------------------------QWKDVN-LQWKPED------------------- --YSG---IKKIRVPSTDIWRPDLVLYNN------ADGDFAIV-----HETKVLLEHTGMITWNPPAIFKSYCE----II VL-------HFPFDLQNCSMKLGTWTYDGNL----VVVNPDSER----------------------------PDLSNFM- -ESGEWVMKDFRGWKHWVYYAC--------------------CPDTPYLDITYHFLMLR--------------------- --------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS -THT-MPNWVRTVFIE-------------TIPNIMFFST----------------------------------------- ----------------------MKRPGKEKQAKSS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------IYGADFDISDISGN-QTTSITYQS--- ------------------------------------------------------------PITKNPDVRSAIEGVKYIAE TMKSDEE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCL IGT-LGVFAGRLIELSML-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNA1_a -------------------------------------------------------------------------------L GFTMYKYILKVLILFSDCCSRS---------------------------------------------VLGSEYETRLVKT LFTG---YNKV-------------------------------------VRPVTHFSQA---------------------- --VEVTVGLQLIQLISVD-------------------------------------------------------------- -----EV-NQIVTSNVRVKQ------------------------------------------------------------ -----------------------------------------------QWTDVN-LKWNPDD------------------- --YGG---IKKIRVPSTDIWKPDLVLYNN------ADGDFAII-----HETKVLLEYSGKITWNPPAIFKSYCE----II VL-------HFPFDLQNCSMKLGIWSYDGLL----VVINPESDK----------------------------PDLSNFM- -ESGEWVLKDSRCWKHWVQYTC--------------------CQDTPYLDITYHFLMLR--------------------- --------------------LPLYFIVNVIIPCLLFSFLTALVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINVHHRSPS -THT-MPQWIRKVFIE-------------TIPNMMVFST----------------------------------------- ----------------------MKRPGQEIRQRR---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------FFPTDMDISDISGNLPPTSITYQS--- ------------------------------------------------------------PIIKNPDVRSAIEGVKHIAE TMKLDEE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMGVCI IGT-VAVFAGRLIELNM--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNA1_b -------------------------------------------------------------------------------- ------MGTLFFAFQVI-ILAG--------------------------------------------AAFASSDETRLVKT LFTG---YNKV-------------------------------------VRPVNHYKDP---------------------- --VVVTVGLQLIQLISVD-------------------------------------------------------------- -----EV-NQIVSSNVRLKQ------------------------------------------------------------ -----------------------------------------------QWKDVN-LQWNPED------------------- --YGG---IRKIRVPSTDIWRPDLVLYNN------ADGDFAIV-----HETKVLLEHTGMITWNPPAIFKSYCE----II VL-------HFPFDLQNCTMKLGTWTYDGNL----VVVNPDSDR----------------------------PDLSNFM- -ESGEWVMKDYRGWKHWVYYAC--------------------CQDTPYLDITYHFLMLR--------------------- --------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS---- ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS -THT-MPDWVRKVFIE-------------TIPNLMFFST----------------------------------------- ----------------------MKRPAKEKQNKP---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------VYTAEFDISEISGN-QATAVHYQS--- ------------------------------------------------------------PLTKNPDVRSAIEGVKYIAE TMKSDEE------------------------------------------------------------------------- ----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMGVCL IGT-LGVFAGRLIELSTY-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNA2 ----------------------------------------------------------------------------MGPS CPVFLSFTKLSLWWLLLTPAG---GEEAKRPPPRAPGDP----------------LSSPSPTALPQGGSHTETEDRLFKH LFRG---YNRW-------------------------------------ARPVPNTSDV---------------------- --VIVRFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWSDYK-LRWNPTD------------------- --FGN---ITSLRVPSEMIWIPDIVLYNN------ADGEFAVT-----HMTKAHLFSTGTVHWVPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQMEQT----------------------------VDLKDYW- -ESGEWAIVNATGTYNSKKYDC--------------------C-AEIYPDVTYAFVIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS -THT-MPHWVRGALLG-------------CVPRWLLMNRPP--------------------------------------- -------------PPVE----LCHPLRLKLSPSYH---------------WLESN------------------------- --------VDAE------------------------------------------------------------------ER EVVVEE-----------------------------------------------------EDR-----------------W ACAGHVAPSVGTL-----------------------------------------CSHGHLHSGASG-------PKAEA-- -------------------------------------------------------LLQEGELLLSPHMQKALEGVHYIAD HLRSEDA------------------------------------------------------------------------- ----------------------------------------------------DSSVKEDWKYVAMVIDRIFLWLFIIVCF LGT-IGLFLPPFLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Macaca_mulatta_CHRNA2 ----------------------------------------------------------------------------MGPS RPAFLSFTKLSLWWLLLTPAG---GEEAKRPPPRAPGDP----------------LSSPSPTALPQGGSHTQAEDRLFKH LFRG---YNRW-------------------------------------ARPVPNTSDV---------------------- --VIVRFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWSDYK-LRWNPAD------------------- --FGN---ITSLRVPSEMIWIPDIVLYNN------ADGEFAVT-----HMTKAHLFSTGTVHWVPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQMEQT----------------------------VDLKDYW- -ESGEWAIVNATGTYNSKKYDC--------------------C-AEIYPDVTYAFVIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS -THT-MPRWVRGALLG-------------CVPRWLLMNRPL--------------------------------------- -------------PSLE----LCHPPGLKLSPSYH---------------WLETN------------------------- --------MDAE------------------------------------------------------------------ER EVVVEE-----------------------------------------------------EDR-----------------W ACAGHVASSVGTL-----------------------------------------CSHGHLHSGASG-------PKAEA-- -------------------------------------------------------VLQEGELLLSPRMQKALEGVHYIAD HLRSEDA------------------------------------------------------------------------- ----------------------------------------------------DSSVKEDWKYVAMVIDRIFLWLFIIVCF LGT-IGLFLPPFLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Mus_musculus_CHRNA2 ----------------------------------------------------------------------------MAPS HPAFQFWIHLYLWCLLLMPAV------------------------------------------LAQQGSHTHAEDRLFKH LFGG---YNRW-------------------------------------ARPVPNTSDV---------------------- --VIVRFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWDPAE------------------- --FGN---ITSLRVPSEMIWIPDIVLYNN------ADGEFAVT-----HMTKAHLFFTGTVHWVPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQMERT----------------------------VDLKDYW- -ESGEWAIINATGTYNSKKYDC--------------------C-AEIYPDVTYYFVIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSECG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS -THN-MPNWVRVALLG-------------RVPRWLMMNRPL--------------------------------------- -------------PPME----LHGSPGLKLSPTYH---------------WLETN------------------------- --------MDAE------------------------------------------------------------------ER EETEEEEE-----------------------------------------------EEEDENI-----------------C MCAGLPDSSMGVL-----------------------------------------YGHGSLHLRAMG-------PEAKT-- -------------------------------------------------------PSQASEILLSPQIQKALEGVHYIAD HLRSEDA------------------------------------------------------------------------- ----------------------------------------------------DSSVKEDWKYVAMVVDRIFLWLFIIVCF LGT-IGLFLPPFLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Felis_catus_CHRNA2 ----------------------------------------------------------------------------MGPS RSAVLSAMRLGLWWLLLSPADL--MGE--GPKHPPPWTP----------------GDPTLPS-CPQGASRTQAEDRLFKH LFRG---YNRW-------------------------------------ARPVPNTSDV---------------------- --VIVRFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LHWNPAD------------------- --FGN---ITSLRVPSEMIWIPDIVLYNN------ADGEFAVT-----HMTKAHLFSTGTVHWVPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQTEQT----------------------------VDLKDYW- -ESGEWAIINATGTYNTKKYDC--------------------C-AEIYPDVTYYFVIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TDIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPR -THT-MPHWVRVAFLG-------------CVPRWLLMNRPV--------------------------------------- -------------PPLE----PRDPPDLKPSSSHY---------------WLETN------------------------- --------VDAE------------------------------------------------------------------ER EEE--K---------------------------------------------------EEEDR-----------------W GWAAHVSPSMGVL-----------------------------------------HGHGGLHQGASG-------PRVEV-- -------------------------------------------------------QLQEGGLLLSPRIQKALEGVHYIAD HLRSEDA------------------------------------------------------------------------- ----------------------------------------------------DSSVKEDWKYVAMVIDRIFLWLFIIVCF LGT-IGLFLPPFLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Monodelphis_domestica_CHRNA2 -----------------------------------------------------------------------------LTM PPPPLKMSDVDVFVLR--------------------------------------------------HASHALDEDRLFKK LFRG---YNRW-------------------------------------SRPVQNSSDV---------------------- --VIIRFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWSDYK-LRWNPTD------------------- --YGN---ITSIRVPSELIWIPDIVLYNN------ADGEFIVT-----HMTKAHLFFTGTVKWAPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQMEQM----------------------------VDLKDYW- -ESGEWAIINAVGTYNTKKYDC--------------------C-VEIYPDITYFFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPG -THN-MPHWVRVAFLG-------------CIPRWLWMNRPL--------------------------------------- -------------PVLE----FHDNPGQKLSSTHH---------------WLDTN------------------------- --------VDED------------------------------------------------------------------KK S----------------------------------------------------------EEN-----------------W EFSGHSSPVIDTL-----------------------------------------YHHCGHHHESPC-------FKAGT-- -------------------------------------------------------QLPETEFLLPPSIQKALEGVHYIAD HLRTEDA------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIICF LGT-IGLFLPPLLA------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNA2_a -----------------------------------------------------------------------------MAE NRIKTLLNNLWMLILIADHVQ----------------------------------------PVLSDGWIHAHAEDKLFHK LFIG---YNKW-------------------------------------SRPVRNISDV---------------------- --VIVKFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWNPSE------------------- --FDN---VTSIRVPSEMIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHTGKVSWVPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQIEGT----------------------------VDLKDYW- -ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS -THS-MPRWVHSVFLD-------------HIPRWLFMRRPE--------------------------------------- -------------PEKKP---KKTANLSTSKSWFQQET------------GVDGLV------------------------ --------CQDMEF------------------------------------------------------------GIGLST SISSPSATSL------------------------------------------------HLSD------------------ SEPLLQKYELQHLG-------------------------------------------HVVNLCQHP-------AKLGN-- -------------------------------------------------------LVSEPGLLFSPCVLRALEGVRYIAD HLRAEDE------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL LGT-IGLFLPPWLSGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNA2_b -------------------------------------------------------------------------------M ASFTNQLVFLRITLLCTIICE----------------------------------------SISCCEKTHSHAEDELFKK LFDG---YNKW-------------------------------------SRPVPNTSDV---------------------- --VIVKFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWKPSD------------------- --YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHTGKVRWVPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLERIENT----------------------------VDLKDYW- -ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS -THK-MPCWVHSVFLD-------------LIPRWLFMRRPA--------------------------------------- -------------PDSR----RRQKLLLLQRQVPG----------------MTARP------------------------ --------ANAS-----------------------------------------------------------------LST STSWFRGQNS------------------------------------------------GEDES----------------C RHFSYKDLELGTLSSAISLSLQASSPCPLGLTPPPLQKFGPAPRLEVG------TASRQLSGRANV-------TKRLDNM ------------------------------------------------------IPHDNPGFPLSPSVLQALEGVHYIAD HLRAEDA------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL LGT-IGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNA2_a -----------------------------------------------------------------------------MKK LQSFTLCFTCHLIVLCIRSVS----------------------------------------AVLCSQKTHSHAEDDLFKK LFAG---YNKY-------------------------------------SRPVPNVTDV---------------------- --VIVKFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWRPSD------------------- --YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFYNGKILWVPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLERIENT----------------------------VDLNNYW- -ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS -THK-MPRWVHSVFLD-------------LIPRWLFMRRPA--------------------------------------- -------------PDGR----RRRLLLLQQEVMAE---------------RRRGRL------------------------ --------TGYKS-------------------------------------------------------------GNYLST SANWLMDGSL------------------------------------------------SDEP------------------ NRNSYEDLELG----------------------------------------------RARITAQRL-------TKADS-- -------------------------------------------------------TVSDSSFLLSPSIIRALEGVHYIAD HLRAEDA------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL LGT-IGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNA2_a -------------------------------------------------------------------------------- --------------------------------------------------------------VLCSQKMHSHSEDALFKK LFAG---YNKY-------------------------------------SRPVPNVTDV---------------------- --VIVKFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWRPSD------------------- --YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHNGKIRWVPPAIYNSSCI----ID VT-------FFPFDQHTARCKFGPCRYDKA-------------------------------------------KLTCYW- -ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS -THK-MPRWVHSVFLD-------------LIPRWLFMRRPA--------------------------------------- -------------PEGR----RRRLLLLQQPPSPRPLG------------TSPPRQ------------------------ --------QNSQK-------------------------------------------------------------KQEVPA GTNQQLSG------------------------------------------------------------------------ ----------------------------------------------------------ARTTAQRL-------TKADS-- -------------------------------------------------------TGSDSYFLLSPSIIRALEGVHYIAD HLRAEDA------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL LGT-IGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNA2_a -------------------------------------------------------------------------------- -----YTIKYEPLRMILFNVS----------------------------------------AVLCHEKSHSHAEDDLFKT LFAG---YNKW-------------------------------------SRPVSNISDV---------------------- --VIVKFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWKPSD------------------- --YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHNGKVRWVPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLERTENT----------------------------VDLNNYW- -ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS -THK-MPHWVHSVFLN-------------LIPRWLFMRRPA--------------------------------------- -------------PDVR----RRRLALMQQDAALV---------------RRQGRA------------------------ --------GGYKRP------------------------------------------------------------SNCLST SATWSGG------------------------------------------------------------------------- ---------------------------------------------------------SRVNLTQRA-------VKADN-- -------------------------------------------------------AVSDSTFLLSPSVIRALEGVHYIAD HLRAEDA------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL LGT-IGLFLPPWLA------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNA2_a -------------------------------------------------------------------------------- ---------------------------------------------------------------FCYDKSHAHAEEELFQT LFTG---YNKW-------------------------------------SRPVPNISDV---------------------- --VIVKFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWKPSD------------------- --YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHTGKVRWVPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLERIENT----------------------------VDLNNYW- -ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS -THK-MPRWVHTVFLD-------------LIPRWLFMRRPA--------------------------------------- -------------PNGR----RRRLLLLQQDGALG---------------RLQPRV------------------------ --------SALD-----------------------------------------------------------------IST SSTWLREGAV------------------------------------------------LEKT------------------ ERSCYEDLELGTLQSYFSFRPPSPRPPGQTPPQQLKTPQNSQSWREG---------GGGPNRQMGG-------ARVDSPK ------------------------------------------------------VQCAESGSLLSPCVMRALEGVHYIAD HLRAEDA------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL LGT-IGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Branchiostoma_floridae_CHRNA2 -------------------------------------------------------------------------------- --------------------------------------------------------------MFLPGGVATQSEERLFRD LFRD---YNKW-------------------------------------IRPVANISNI---------------------- --VVIEFGLAIAQLLDVD-------------------------------------------------------------- -----EK-NQIMTTNVWLK------------------------------------------------------------- ----------------------------------------------QKWKDSK-LCWDPDE------------------- --YHG---VSVIRVPSDMIWLPDIVLYNN------ADGNYAVK-----HNTKAQISSDGMVTWEPPAVYKSSCE----IE VT-------YFPFDQQNCSMKFGSWTYDGFQ----IDLMMMDDH----------------------------VDQGGFS- -ESGEWVIIDAPGQKNIIKYEC--------------------C-EEVYPDITFFFVIRR--------------------- --------------------LPLFYTINLIVPCALISFLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPATSIVIPVIGEYLLFTMIFVTLSIVITVFVLNIHYRSPS -THR-MPVWVRKIFID-------------ILPRLLSDVYDY--------------------------------------- ---------------------ESKTLPRMTTPKMR--------------------------------------------- ----------SR-----------------------------------------------------------------HGA KVSVTNVSG----------------------------------------------------------------------- ------NPGVGG------------------------------------------AEKYNTCDSRPS--------QSQA-- -------------------------------------------------------RAQFQSYQYSPDILRAAQGVNYIAE TLRAKDE------------------------------------------------------------------------- ----------------------------------------------------ADSVNEDWKYVAMVIDRIFLWIFVSMCI LGT-IGLFLQP-LPGFIS-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Drosophila_melanogaster_CHRNA2 -------------------------------------------------------------------------------- ----MGSVLFAAVFIALHFATGG---------------------------------------------LANPDAKRLYDD LLSN---YNRL-------------------------------------IRPVGNNSDR---------------------- --LTVKMGLRLSQLIDVN-------------------------------------------------------------- -----LK-NQIMTTNVWVE------------------------------------------------------------- ----------------------------------------------QEWNDYK-LKWNPDD------------------- --YGG---VDTLHVPSEHIWLPDIVLYNN------ADGNYEVT-----IMTKAILHHTGKVVWKPPAIYKSFCE----ID VE-------YFPFDEQTCFMKFGSWTYDG------YMVDLRHLK-----------------QTADSDNIEVGIDLQDYY- -ISVEWDIMRVPAVRNEKFYS---------------------CCEEPYLDIVFNLTLRR--------------------- --------------------KTLFYTVNLIIPCVGISFLSVLVFYLPSDSG-------------------EKISLC---- ISILLSLTVFFLLL----------------------AEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPV -THR-MAPWVQRLFI--Q-----------ILPKLLCIERPKKE-EP---------------EEDQPPEVLTDVYHLPPDV DKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAH------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------CFAEPPLPSSLPLPGADDDLFSPSGL ------------------------------------NGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQ HVKNKDKFE----------------------------------------------------------------------- ------------------------------------------------------SVEEDWKYVAMVLDRMFLWIFAIACV VGT-ALIILQAPSLYDQSQPID--ILYSKIAKKKFELLKMGSENTL---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Apis_mellifera_CHRNA2 -------------------------------------------------------------------------------M FKMQILTLGVLFNTLHIIYSVAGLKI-----------------------------------------FEANPDTKRLYDD LLSN---YNRL-------------------------------------IRPVMNNTET---------------------- --LTVQLGLKLSQLIEMN-------------------------------------------------------------- -----LK-NQVMTTNVWVE------------------------------------------------------------- ----------------------------------------------QRWNDYK-LKWNPEE------------------- --YGG---VEMLYVPSENIWLPDIVLYNN------ADGNYEVT-----LMTKATLKYTGDVSWKPPAIYKSSCE----IN VE-------YFPFDEQSCIMKFGSWTYNG------AQVDLKHMK-----------------QEAGSNLVAKGIDLSDFY- -LSVEWDILEVPASRNEEYYP---------------------CCTEPYSDITFNITMRR--------------------- --------------------KTLFYTVNLIIPCVGITFLTVLVFYLPSDSG-------------------EKVSLC---- SSILLSLTVFFLLL----------------------AEIIPPTSLAIPLLGKYLLFTMILVTLSIWITVCVLNVHFRSPS -THN-MSPWVRQVFL--N-----------WMPRLLMMRRTPYSTPEYD-------------------------------- --------------------DTYMDSGYTNEIDFSFP------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------DSVSDYPLELKGSPDGFESVTSQYK- --------------------------------------NIREDDARHIPHASVTDSENTVPRYLSPDVISALKGVRFIAQ HIKNADKDN----------------------------------------------------------------------- ------------------------------------------------------EVIEDWKFVAMVLDRLFLWVFTLACT AGT-LGIIFQAPSLYDTREPVD--QQLSGISPR--NYMYPNIDISPEG-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Anopheles_gambiae_CHRNA2 -------------------------------------------------------------------------------- ----MGSVLLTAVFIALQFATG----------------------------------------------LANPDSKRLYDD LLSN---YNRL-------------------------------------IRPVGNNSDR---------------------- --LTVKMGLRLSQLIDVN-------------------------------------------------------------- -----LK-NQIMTTNVWVE------------------------------------------------------------- ----------------------------------------------QEWNDYK-LKWNPDD------------------- --YGG---VDTLHVPSEHIWLPDIVLYNN------ADGNYEVT-----IMTKAILHHTGKVVWKPPAIYKSFCE----ID VE-------YFPFDEQTCFMKFGSWTYDG------YMVDLRHLQ-----------------QTPDSDNIDIGIDLQDYY- -ISVEWDIMKVPAVRNEKFYS---------------------CCEEPYPDIIFNITLRR--------------------- --------------------KTLFYTVNLIIPCVGISFLSVLVFYLPSDSG-------------------EKISLC---- ISILLSLTVFFLLL----------------------AEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPV -THR-MAPWVHRVFI--E-----------LLPKVLCIERPKKEDEPSD------------NDDQTPTDVLTDVFQVPPDV EKYVGFCGKEYGTDFDIPALPPS-RFDVAASGGVGP-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------CFGEPPLP-ALPLPGGDDDLFSPTG- ------------------------------------NGDMSPTCC--------GDLSPTFEKPLLREMEKTIEASRFVAQ HVRNKDKFE----------------------------------------------------------------------- ------------------------------------------------------SVKEDWKYVALVLDRLFLWIFTIACV LGT-CLIILQAPSLYDNTQPID--AMYSKIAKKKMELLKMGSENV----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Amphimedon_queenslandica_CHRNA2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MSSSRSLSSS---------------------- -----RSKSHLSKSSKFES------------------------------------------------------------- --------TAELPSEVMVN------------------------------------------------------------- --------------------------------------------------TPEQLSWQVLS------------------- ----------QTQVARFKALSPTELTKEL-------STVLSLS-----KHEEDLQQAAILDYYVSSFVFAQEKD------ ------------FTDEQLSSFFTIIHKLLAN--------IREKR----------------------------TTLQDNLN ELKSYFAGVGVSDQTCLKCFTP------------------------KVAMATISYIHTS--------------------- ----------------------------------LVQHYTLFEYILQEKQE-------------------DEFIQT---- -----QLLVSLP---------------------------PDSSTLSPPPLEESVTEDFYNRLVSTAPAGSPSQTQLGSPT -THS-PPHSIQGTDMSSPTG---------AIPPTLLLNLRP--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------EDVKMMTE KLLEETVTP----------------------------------------------------------------------- -------------------------------------------------------------YQDEMLRKLVDRETSYKSK LDKLEKSLT----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNA6 ---------------------------------------------------------------------MLTSKGQGFLH ----GG---LCLWLCVFT--PFF------------------------------------------KGCVGCATEERLFHK LFSH---YNQF-------------------------------------IRPVENVSDP---------------------- --VTVHFEVAITQLANVD-------------------------------------------------------------- -----EV-NQIMETNLWLR------------------------------------------------------------- ----------------------------------------------HIWNDYK-LRWDPME------------------- --YDG---IETLRVPADKIWKPDIVLYNN------AVGDFQVE-----GKTKALLKYNGMITWTPPAIFKSSCP----MD IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW- -ENSEWEIIDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR--------------------- --------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT -THT-MPRWVKTVFLK-------------LLPQVLLMRWPLD-------------------------------------- ------------KTRGTGSDAVPRG---LARRPAKGK------------------------------------------- -----------------------------------------------------------------------------LAS HGEPRHL------------------------------------------------------------------------K ECFHCHKSN-------------------------------------------ELATS-KRRLSHQPLQWVVENSEHS--- -----------------------------------------------------------------PEVEDVINSVQFIAE NMKSHNE------------------------------------------------------------------------- ----------------------------------------------------TKEVEDDWKYVAMVVDRVFLWVFIIVCV FGT-AGLFLQPLLGNTGKS------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Pongo_abelii_CHRNA6 ---------------------------------------------------------------------MPTSKGQGFLH ----GG---LCLWLCVFT--PFF------------------------------------------KGCAGCVTEERLFHK LFSH---YNQF-------------------------------------IRPVENVSDP---------------------- --VTVHFEVAITQLANVD-------------------------------------------------------------- -----EV-NQIMETNLWLR------------------------------------------------------------- ----------------------------------------------HIWNDYK-LRWDPTE------------------- --YDG---IETLRVPADKIWKPDIVLYNN------AVGDFQVE-----GKTKALLKYNGMITWTPPAIFKSSCP----MD IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW- -ENSEWEIIDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR--------------------- --------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVVPLVGEYLLFTMIFVTLSIMVTVFVLNIHYRTPT -MHT-MPRWVKTVFLK-------------LLPQVLLMRWPVD-------------------------------------- ------------KTRGTGSDAMPRG---LARRPAKGK------------------------------------------- -----------------------------------------------------------------------------LAS REEPRHL------------------------------------------------------------------------K ECFHCHKSN-------------------------------------------ELATS-KRRLSHQPLQWMVENSEHS--- -----------------------------------------------------------------PEVEDVINSVQFIAE NMKSHNE------------------------------------------------------------------------- ----------------------------------------------------TKQVEDDWKYVAMVVDRVFLWVFIIVCV FGT-AGLFLQPLLGNTGKS------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Mus_musculus_CHRNA6 ---------------------------------------------------------------------MLNSRDQGNLH ----SG---LCLWLCGFL--ALF------------------------------------------KGSTGCESEEQLFHR LFAH---YNRF-------------------------------------IRPVENVSDP---------------------- --VTVHFELAITQLANVD-------------------------------------------------------------- -----EV-NQIMETNLWLR------------------------------------------------------------- ----------------------------------------------HIWKDYR-LRWDPTE------------------- --YDG---IETLRVPADNIWKPDIVLYNN------AVGDFQVE-----GKTKALLKYDGVITWTPPAIFKSSCP----MD IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW- -ENSEWEIVDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR--------------------- --------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPA -THT-MPKWVKTIFLQ-------------AFPSILMMRKPLD-------------------------------------- ------------KTKEAGGVKDPKS---HTKRPAKVK------------------------------------------- -----------------------------------------------------------------------------FTH RGESKLL------------------------------------------------------------------------K ECHHCQKSS-------------------------------------------DIAPG-KRRSSQQPARWVAENSEHS--- -----------------------------------------------------------------SDVEDVIESVQFIAE NMKSHNE------------------------------------------------------------------------- ----------------------------------------------------TNEVEDDWKYMAMVVDRVFLWVFIIVCV FGT-VGLFLQPLLGNTGKS------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Canis_familiaris_CHRNA6 ---------------------------------------------------------------------MLTSKGQGFLH ----FG---LCLCSCIFI--PCL------------------------------------------KGSAGCASEERLFHK LFSH---YNQF-------------------------------------IRPVENVSDP---------------------- --VTVHFEVAITQLANVD-------------------------------------------------------------- -----EV-NQIMETNLWLR------------------------------------------------------------- ----------------------------------------------HIWNDYK-LRWNPME------------------- --YDG---IETLRVPADRIWKPDIVLYNN------AVGDFQVE-----GKTKALLKYDGMIIWTPPAIFKSSCP----MD IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW- -ENSEWEIVDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR--------------------- --------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLVGEYLLFTMIFVTLSIAVTVFVLNIHYRTPA -THT-MPKWVKTVFLQ-------------LLPQILMMRRPLD-------------------------------------- ------------KMRKTSSDKNSKG---ISSRPTKVN------------------------------------------- -----------------------------------------------------------------------------FDN YRETKLP------------------------------------------------------------------------K ECCHCHKSS-------------------------------------------KLATS-KRRLSHQSLQWMTENSEHW--- -----------------------------------------------------------------PDVEDVINSVQFIAE NMKNQNE------------------------------------------------------------------------- ----------------------------------------------------TKEVEDDWKYVAMVVDRVFLWVFIFVCV FGT-AGLFLQPLLGNTGKS------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Myotis_lucifugus_CHRNA6 ---------------------------------------------------------------------MLTSKGQGCLH ----CG---LCLWLYIFI--PFF------------------------------------------KDGAGCASEERLFHK LFSH---YNQL-------------------------------------IRPVENVSEP---------------------- --VTVHFEVAITQLANVD-------------------------------------------------------------- -----EV-NQIMETNLWLR------------------------------------------------------------- ----------------------------------------------HIWNDYK-LRWDPTE------------------- --FDG---IETIRVPADKIWKPDIVLYNN------AVGDFQVK-----GKTKALLKYDGMITWTPPAIFKSSCP----MD IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW- -ENSEWEIVDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR--------------------- --------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLVGEYLLFTMIFVTLSIAVTVFVLNIHYRTPT -THT-MPDWVKMVFLQ-------------LLPQILMMKRPLD-------------------------------------- ------------KTRKTSSDKNPKS---ISGRPTKVK------------------------------------------- -----------------------------------------------------------------------------FDN RREPKLL------------------------------------------------------------------------K ECCHCHKSH-------------------------------------------QLATS-KRRLSHQPLQWMTGNTEHS--- -----------------------------------------------------------------PEVEDVINSVQFIAE NMKNQNE------------------------------------------------------------------------- ----------------------------------------------------TKEVEDDWKYVAMVVDRVFLWIFIIVCV FGT-AGLFLQPLLGNTGKS------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Ciona_savignyi_CHRNA6 -------------------------------------------------------------------------------- ------------------------------------------------------------------------TEEKLFKR LFDD---YNIW-------------------------------------IRPVANSNQS---------------------- --VLIAFELFVSQLVKVD-------------------------------------------------------------- -----EI-NQIMMTNLWLK------------------------------------------------------------- ----------------------------------------------QEWNDNK-LRWRPED------------------- --YGG---VKYLRVPSEFIWKPDIVLYNT------AVGKFQVD-----QNTKALLRYNGDVSWMPPAIFKSSCS----ID VT-------YFPFDTQNCTMKFGSWTYDKAR----VNLVIKGNE----------------------------ANRKEYW- -ESGEWELLDVLGYRHERKYNC--------------------C-PEIYPDVTYSFHIRR--------------------- --------------------LPLFYMINLIIPCLLISFLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLVI----------------------TEIIPSTSLVIPLIGQYLLFTMIFVTLSIVITVFVLNVHFRSEN -THT-MPPWVRRVFLE-------------CLPKASCFSHLFHS------------------------------------- -------------SISSHNHNNVNKSLAHSATSLTHH------------------------------------------- -----------------------------------------------------------------------------STS PTHNTTTA------------------------------------------------------------------------ -ICHMNR-----------------------------------------------------------VSNAEKTEKTPDS- --------------------------------------------------------------ALPKEVQRAIESVMYIAN HLKVEDE------------------------------------------------------------------------- ----------------------------------------------------STEIENDWKYVGMVIDRIFLWIFIVVCV LGT-TGIFLRPLLDDTHVG------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNB3 -------------------------------------------------------------------------------- -----MLPDFMLVLIVLGIPSS----------------------------------------ATTGFNSIAENEDALLRH LF--QG-YQKW-------------------------------------VRPVLHSNDT---------------------- --IKVYFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWTDHK-LRWNPDD------------------- --YGG---IHSIKVPSESLWLPDIVLFE------NADGRFEGS-----LMTKVIVKSNGTVVWTPPASYKSSCT----MD VT-------FFPFDRQNCSMKFGSWTYDGTM----VDLILINEN----------------------------VDRKDFF- -DNGEWEILNAKGMKGNRRDGV--------------------Y---SYPFITYSFVLRR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSS -TYHPMAPWVKRLFLQ-------------KLPKLLCMKDHVD-------------------------------------- ---------------------RYSSPEKEESQPVVKG------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------KVLEKKKQKQLSDG----------- ------------------------------------------------------------EKVLVAFLEKAADSIRYISR HVKKEHFIS----------------------------------------------------------------------- ------------------------------------------------------QVVQDWKFVAQVLDRIFLWLFLIVSV TGS-VLIFTPALKMWLHSYH------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Callithrix_jacchus_CHRNB3 -------------------------------------------------------------------------------- -----MLTDFMLVLIVLGIPSS----------------------------------------ATAGFSSIAENEDALLRH LF--QG-YQKW-------------------------------------VRPVLHSNDT---------------------- --IKVYFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWTDHK-LRWNPDD------------------- --YGG---IHSIKVPSESLWLPDIVLFE------NADGRFEGS-----LMTKVIVKSNGTVVWTPPASYKSSCT----MD VT-------FFPFDRQNCSMKFGSWTYDGTM----VDLILINEN----------------------------VDRKEFF- -DNGEWEILNAKGMKGNRRDGV--------------------Y---SYPFITYSFVLRR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSS -TYQPMAPWVKRLFLQ-------------KLPKLLCMKDHVD-------------------------------------- ---------------------RYSIPEKEESQPVVKS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------KVLEKKKHKQLSDG----------- ------------------------------------------------------------EKVLVAFLEKAADSIRYISS HVKKEHFIS----------------------------------------------------------------------- ------------------------------------------------------QVVQDWKFVAQVLDRIFLWLFLIVSV TGS-VLIFTPALKMWLHSYH------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gallus_gallus_CHRNB3 -------------------------------------------------------------------------------- --------MLCLMLCVLCWSR----------------------------------------SDVAALGSVAENEDALLRH LF--QG-YQKW-------------------------------------VRPVENSNDT---------------------- --IKVLFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWMDHK-LSWNPEE------------------- --YGG---ITAIRVPSESLWLPDIVLFE------NADGRFEGS-----LMTKAIVKYNGVVTWMPPASYKSSCT----MD VT-------FFPFDRQNCSMKFGSWTYDGSM----VDLILVDEN----------------------------VDRKDFF- -DNGEWEILNAKGMKGNRKDGL--------------------Y---SYPFVTYSFVLRR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA -TYHPMAPWVKRLFLQ-------------KLPRLLCMKGHVD-------------------------------------- ---------------------RYSFSDTEEKETTLKS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------KLPGKQKHKQAKDG----------- ------------------------------------------------------------EKVVIAFLEKAADSIRYISR HVKKEHFIR----------------------------------------------------------------------- ------------------------------------------------------QVVQDWKFVAQVLDRIFLWLFLVVSV TGS-VLIFTPALQMWLNSTL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Xenopus_tropicalis_CHRNB3 -------------------------------------------------------------------------------- ---TMKMFIYACTNIIFIPSG------------------------------------------FAKFHPLAEIEDALLRK LF--AG-YQKW-------------------------------------VRPVLNPNST---------------------- --IKVNFGLKISQLVDVD-------------------------------------------------------------- -----EK-KQLMTTNVWLR------------------------------------------------------------- ----------------------------------------------QEWMDMK-LRWNPKD------------------- --YGG---ITYIRVPSESLWLPDIVLFE------NADGRFEGS-----LMTKAIIKYDGTVTWTPPASYKSSCT----MD VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLILLDEN----------------------------VDRKDFF- -DNGEWDILNATGLKGMRKDGL--------------------Y---SYPFITYSFVLRR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA -TYHPMAPWVKRLFLE-------------KLPKLLCMKGHVD-------------------------------------- ---------------------RFSFFDSESDVSSAKS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------KPSGKRKNIHASDG----------- ------------------------------------------------------------EKVLIAFLEKAADSIKYIST HVKKEHFIR----------------------------------------------------------------------- ------------------------------------------------------QVVQDWKFVAQVLDRIFLWLFLSVSI TGS-VLIFTPALQMWLNSHV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNB3_a -------------------------------------------------------------------------------- -----MKLQISGILLVAAVAYA-------------------------------------TIEAPEEFVSLAEMEDTLLRN LF--RG-YQKW-------------------------------------VRPVLHANDT---------------------- --ITVRFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLW------------------------------------------------------------- ----------------------------------------------EEWTDYK-LRWNPED------------------- --YGG---ITSIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRFNGTIMWTPPASYKSACT----MD VT-------FFPFDRQNCSMKFGSWTYDGTM----VDLTLVDAY----------------------------VDRKDFF- -DNGEWEILNATGQRGSRRDGI--------------------Y---SYPYLTYSFILKR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSA -TYHPMAPWVKSLFLQ-------------RLPRLLCMRGHTD-------------------------------------- ---------------------RYQYPDIELRSPELKR------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------G---MKKGQQKSAGG--GRAGVKE- ----------------------------------------------------------DENQAWIALLEKATHSVHYISR HIRKEHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSV LGT-ILIFTPALQMFFSTS------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNB3_b -------------------------------------------------------------------------------- -----MTLTVIGLFTLFTSIFA-------------------------------------TTP-AREFVSLAEREDALLRD LF--QG-YQRW-------------------------------------VRPILHANHT---------------------- --VKVRFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLY------------------------------------------------------------- ----------------------------------------------EEWLDYK-LRWNPEN------------------- --YGG---ITFIRVPSESIWLPDIVLYE------NADGRFEGS-----IMTKAIVRYNGLITWTPPASYKSACT----MD VT-------FFPFDRQNCSMKFGSWTYDGNM----VELVLVNHQ----------------------------VDRSDFF- -DNGEWEILSATGHKGSRRDGH--------------------Y---SYPYITYSFILKR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKVSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA -TYHPMSPWVRTLFLQ-------------RLPDLLCMRGNTD-------------------------------------- ---------------------RYHYPQMEPQSPDLKP------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------R---SKKGPPGPEG----------- -----------------------------------------------------------DGQALINMLEQATNSVRYISR HIKKEHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSV LGT-ILIFTPAVKMFLSTPPPPSP-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNB3_a -------------------------------------------------------------------------------- ---------PPLLSVLLSVPIP-------------------------------------LAPAEEDFVSLAELEDSLLRN LF--KG-YQKW-------------------------------------VRPVQHANDT---------------------- --ITVRFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLW------------------------------------------------------------- ----------------------------------------------QEWIDVK-LKWNPDD------------------- --YGG---ITAIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRWDGTITWTPPASYKSACN----MD VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLVDHY----------------------------VDRKDFF- -DNGEWEILNATGVKGSRRDEV--------------------Y---WYPFVTYSFILKR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSA -TYHPMAPWVKSLFLQ-------------RLPRLLCMRGHTD-------------------------------------- ---------------------RYNFPDNEMRSPEPKP------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------R---RAIGRRGVQG--------KE- ----------------------------------------------------------DENQAWLAMLEKATNSVRYISQ HIRKEHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSI LGT-VLIFTPALKMYLHKMFH----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNB3_b -------------------------------------------------------------------------------- ---------HLPDQLVCAKTSL-------------------------------------SAPAQSEFVSLAEMEDALLRN LF--QG-YQRW-------------------------------------VRPIQHANDT---------------------- --IKVRFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLC------------------------------------------------------------- ----------------------------------------------QEWIDFK-LRWNPDK------------------- --YGG---ITSIRVPSENLWLPDIVLYE------NADGRFEGS-----LMTKAIVRYNGAITWTPPASYKSACT----MD VT-------FFPFDRQNCTMKFGSWTYDGTM----VDLILIDKQ----------------------------VDRKDFF- -DNGEWEILSATGAKGNRKDGL--------------------Y---SYPFITYSFILKR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA -TYHPMSPWVRTLFLQ-------------KLPSLLCMRGHTD-------------------------------------- ---------------------RYHYPELGPESPEPKP------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RSGGRRGGQRISSGGTYGQASSEG- ----------------------------------------------------------KDDEDWATMLDKAIFSVRYISR HIRKEHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSV LGT-ILIFTPALQKFMQVLP------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNB3_a -------------------------------------------------------------------------------- --------LLVASVCFFPVFHM-------------------------------------FAPAQSEFVSLAEMEDALLRN LF--QG-YQRW-------------------------------------VRPIQHANDT---------------------- --IKVRFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLC------------------------------------------------------------- ----------------------------------------------QEWIDYK-LRWNPDK------------------- --YGG---ITSIRVPSENLWLPDIVLYE------NADGRFEGS-----LMTKAIVRYNGAITWTPPASYKSACT----MD VT-------FFPFDRQNCTMKFGSWTYDGTM----VDLILIDKQ----------------------------VDRKDFF- -DNGEWEILSATGAKGNRKDGL--------------------Y---SYPFITYSFILKR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA -TYHPMSPWVRTLFLQ-------------KLPRLLCMRGHTD-------------------------------------- ---------------------RYHYPELGPESPEPRV------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RAGGRRGGQRVGSG-SHGQTPPEG- ----------------------------------------------------------KDDEEWASMLDKAIYSVRYISR HIRKEHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSV LGT-ILIFTPALQKFMKVLPQSSS-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNB3_b -------------------------------------------------------------------------------- ---------------------------------------------------------------QEDFVSLAELEDSLLRN LF--RG-YQKW-------------------------------------VRPVQHANDT---------------------- --ITVRFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLW------------------------------------------------------------- ----------------------------------------------QEWVDVK-LKWNPDD------------------- --YGG---ITAIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRWDGTITWTPPASYKSACT----MD VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLVDHY----------------------------VDRKDFF- -DNGEWEILNATGVKGSRRDGI--------------------Y---WYPFVTYSFILKR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSA -TYHPMAPWVKSLFLQ-------------RLPRLLCMRGHTD-------------------------------------- ---------------------RYHFPDMEMHSPELKP------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------R---RAVGRRGVQGQQKGPLAGKE- ----------------------------------------------------------DENQAWLAMLEKATNSVRYISQ HIRKEHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSI LGT-VLIFTPALQMYLSTP------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNB3_a -------------------------------------------------------------------------------- ---------------------------------------------------------------QDDVVSLAEMEDSLLRN LF--RG-YQKW-------------------------------------VRPVLHSNDT---------------------- --ITVCFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLW------------------------------------------------------------- ----------------------------------------------QEWVDLK-LKWNPDD------------------- --YGG---ITSIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRWDGTITWTPPASYKSACT----MD VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLVDHY----------------------------VDRKDFF- -DNGEWEILNATGQRGSRRDEV--------------------Y---WYPFVTYSFILKR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYL--------------------HHRSSS -TYHPMAPWVKSLFLQ-------------RLPRLLCMRGHTD-------------------------------------- ---------------------RYHFEDMEMHSPEVKT------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------R---RGVGRRGAPGQ-RGPVSGKE- ----------------------------------------------------------EENRAWLAMLEKATSSVRYISR HIKKEHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRILLWAFLTVSI LGT-VLIFTPALQMYFSTP------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNB3_b -------------------------------------------------------------------------------- -----MKWTVLFLLLVCPLSLA-------------------------------------EIHAPSEFVSLAEMEDALMRN LF--QG-YQRW-------------------------------------VRPIQHANDT---------------------- --VRVRFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLW------------------------------------------------------------- ----------------------------------------------QEWIDYK-LRWNPDK------------------- --YGG---ITSIRVPSEIIWLPDIVLYE------NADGRFEGS-----LMTKAIVKFNGVITWTPPASYKSACT----MD VT-------FFPFDRQNCTMKFGSWTYDGHM----VDLVLIDNQ----------------------------VDRRDFF- -DNGEWEILSATGARGTRKDDM--------------------Y---TYPFLTYSFILKR--------------------- --------------------LPLFYTLFLIFPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLL---------------------RSSA -TYHPMSPWVRNLFLQ-------------KLPRFLCMRGHTD-------------------------------------- ---------------------LYHYPELAPESPEMKP------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RSGGRKGGQRANSG-ARGQTASEG- ----------------------------------------------------------KEDEAWATMLDKAVYSVRYISR HIRKEHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSI LGT-VLIFTPALYSFFKIP------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNB3_a -------------------------------------------------------------------------------- --------------------FP-------------------------------------LLPVQENVLSLAELEDSLLRN LF--KG-YQKW-------------------------------------VRPVQHANDT---------------------- --ITVRFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLW------------------------------------------------------------- ----------------------------------------------QEWIDVK-LKWNPDD------------------- --YGG---ITSIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRWDGTITWTPPASYKSSCT----MD VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLVDHY----------------------------VDRKDFF- -DNGEWEILNATGQRGSRRDEM--------------------Y---WYPFLTYSFILKR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSA -TYHPMAPWVKSLFLQ-------------KLPRLLCMRGHTD-------------------------------------- ---------------------RYHFPDIEMRSPELKT------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------R---RGAGRRAVPG-------GME- ----------------------------------------------------------DDSQAWLAMLEKATNSVHYISR HIRKEHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSI LGT-VLIFTPALQSYLSTP------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNB3_b -------------------------------------------------------------------------------- -----LTVFLLLLLSACPQLFA-------------------------------------AITAPKRFVSLAEMEDDLLKN LF--QG-YQRW-------------------------------------VRPIQRPNDT---------------------- --VRVRFGLKISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLR------------------------------------------------------------- ----------------------------------------------QEWIDYK-LRWNPDK------------------- --YGG---ITSIRVPSENIWLPDIVLYE------NADGKFEGS-----LMTKAIVKFNGAVTWMPPASYKSACT----MD VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLMDSQ----------------------------VDRKDFF- -DNGEWEILSATGAKGNRKDGL--------------------Y---FYPFITCSFILKR--------------------- --------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA -TYHPMSPWVRSLFLQ-------------KLPRLLCMRGHAD-------------------------------------- ---------------------RYHYPELAPESPALKS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RSGGRRGIQRMSSG--GQQSTYDG- ----------------------------------------------------------KEEEAYSTMLEKAIYSVRYISR HIRKDHFIR----------------------------------------------------------------------- ------------------------------------------------------EVVQDWKFVAQVLDRIFLWIFLSVSV LGT-ILIFTPALQMFMKIPPPAPSE------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNA4 ----------------------------------------------------------------------------MELG GPGAPRL--LPPLLLLLGTGLLR---------------------------------------ASSHVETRAHAEERLLKK LFSG---YNKW-------------------------------------SRPVANISDV---------------------- --VLVRFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWVK------------------------------------------------------------- ----------------------------------------------QEWHDYK-LRWDPAD------------------- --YEN---VTSIRIPSELIWRPDIVLYNN------ADGDFAVT-----HLTKAHLFHDGRVQWTPPAIYKSSCS----ID VT-------FFPFDQQNCTMKFGSWTYDKAK----IDLVNMHSR----------------------------VDQLDFW- -ESGEWVIVDAVGTYNTRKYEC--------------------C-AEIYPDITYAFVIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSECG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPR -THT-MPTWVRRVFLD-------------IVPRLLLMKRPS--------------------------------------- -------------VVKDNCRRLIESMHKMASAPRF---------------WPEPE--GEPPATSGTQSLHP-------PS PSFCVPLDVPAEPGP--------------------SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPP-HGTQAPGLAKAR SLSVQHMSS---------------------------------------------PGEAVEGGVRCR-------------S RSIQYCVPRDDAAPEADGQA------AGALAS----RNTHSAELP----PPDQPSPCKCTCKKEPSSVSPSATVKTRS-- ------------------------------------------------------TKAPPPHLPLSPALTRAVEGVQYIAD HLKAEDT------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL LGT-VGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Mus_musculus_CHRNA4 ----------------------------------------------------------------------------MEIG GSGAPPPLLLLPLLLLLGTGLLP---------------------------------------ASSHIETRAHAEERLLKR LFSG---YNKW-------------------------------------SRPVANISDV---------------------- --VLVRFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWVK------------------------------------------------------------- ----------------------------------------------QEWHDYK-LRWDPGD------------------- --YEN---VTSIRIPSELIWRPDIVLYNN------ADGDFAVT-----HLTKAHLFYDGRVQWTPPAIYKSSCS----ID VT-------FFPFDQQNCTMKFGSWTYDKAK----IDLVSMHSR----------------------------VDQLDFW- -ESGEWVIVDAVGTYNTRKYEC--------------------C-AEIYPDITYAFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSECG-------------------EKVTLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPR -THT-MPAWVRRVFLD-------------IVPRLLFMKRPS--------------------------------------- -------------VVKDNCRRLIESMHKMANAPRF---------------WPEPE--SEPGILGDICNQGLS------PA PTFCNRMDTAVETQP--------------------TCRSPSHKVPDLKTSEVEKASPCPSPGSCHPP-NSSGAPVLIKAR SLSVQHVPS---------------------------------------------SQEAAEGSIRCR-------------S RSIQYCVSQDGAASLTESKP------TGSPAS----LKTRPSQLP----VSDQTSPCKCTC-KEPSPVSPITVLKAGG-- ------------------------------------------------------TKAPPQHLPLSPALTRAVEGVQYIAD HLKAEDT------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL LGT-VGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Monodelphis_domestica_CHRNA4 ----------------------------------------------------------------------------MRLQ GPQGSALLLLLLRGLLILGVLLP---------------------------------------ASGHVETRAHAEERLLKK LFSG---YNKW-------------------------------------SRPVANISDV---------------------- --VLVRFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNMWVK------------------------------------------------------------- ----------------------------------------------QEWQDYK-LRWDPMD------------------- --YEN---VTSIRIPSELIWRPDIVLYNN------ADGDFAVT-----HLTKAHLFYDGRIKWTPPAIYKSSCS----ID VT-------FFPFDQQNCTMKFGSWTYDKAK----IDLVSMHSH----------------------------VDQLDYW- -ESGEWVIISAVGNYNIKKYEC--------------------C-TETYSDITYSFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPR -THT-MPAWVRRVFLD-------------IIPRLLFMKRPG--------------------------------------- -------------VVKDNCRKLVESMHKLAGGPRF---------------WPQP----EPNFVTSPSTSPQTPE--RSPS ASFCVHLEDPVKPQA--------------------VCKSPSGQYTVLQRPEPGKGS-PCSPPTPHPPLNNSHPSGFSKVR SLSVQQMYS---------------------------------------------SNKVEEGSIRCR-------------S RSIQYCSLQEDSSQANNGQS------TSSPAS----LRSQKDEVQ----PQEKPSPCKCKCKKVKATPVPDPVTKPRS-- -------------------------------------------------------TKEQHALPMSPALKLAVEGVQYIAD HLKAEDT------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFVIVCL LGT-VGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNA4_a -------------------------------------------------------------------------------M RAAWRVFFLLCVHLQLAY--------------------------------------------VFSMSPAHAHAEERLLQS LFIN---YNKL-------------------------------------SRPVANISDV---------------------- --VLVHFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWVK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWNPEE------------------- --YEN---VTSIRIPSEIIWRPDIVLYNN------ADGDFAVT-----HLTKAQVFYNGRIKWKPPAIYKSSCS----ID VT-------FFPFDQQNCKMKFGSWTYDRAK----IDLISMASD----------------------------VDQMDYW- -ESGEWVIINAVGTYNIKKYEC--------------------C-TEIYPDITYSFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSECA-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSSR -THS-MPHWVRQLFLH-------------LVPRYLFMKRPP-A------------------------------------- -------------SGKRNCGKLIEMMHKQANSQSMFLRNN----------ILDISPQSPIPHLGPTSAAQQDQVQQDSTS PKPLFFCSSPSSQYSI--------------LQEENSQTPQTPVLSYTCAYTNSIFASSTTSFPDTLLGTLLHTIPQDGAK STECDFQGHS-------------------------------------------AESVFMEAKESVLG------------A GSCQHCLTSEGTSLQKLDLD----------------------------------EAGRCTRHNMPSAQIFSPSSDGST-D ------------------------------------------------------LNAAEPVSNLSQSLLKALEGVQYIAD HLRAEDS------------------------------------------------------------------------- ----------------------------------------------------DFSVREDWKYVAMVIDRIFLWMFVLVCI LGT-VGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNA4_a -------------------------------------------------------------------------TEWISSG LDPPALPHHLHFIWITSSSLAG-----------------------------------------FSQVAPRAHAEERLLQD LFAH---YNKL-------------------------------------SRPVENTTDT---------------------- --VLVHFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWVK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWNPEE------------------- --YEN---VTSIRIPSEIIWRPDIVLYNN------ADGDFAVT-----HLTKAQLFYDGRIKWMPPAIYKSSCS----ID VT-------FFPFDQQSCKMKFGSWTYDRAK----IDLISMASD----------------------------VDQMDYW- -ESGEWVIVNAVGKYNTKKYEC--------------------C-TEIYSDITYYFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSQCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMVFVTLSIIITVFVLNVHHRSPQ -THG-MPHWVRRVFLD-------------FVPKVLFMKRPP-G------------------------------------- -------------TAKQHCKKLIEMMHRPATVSGP--------------------------------------------S PSPPSSPLANCNKDNQSLNANTFCQSISGRYSLLSEKQLLHGHKSAASSSSQLSLPPTLPLGLLHKRTNKESNTMASIGR SLSVEHMFDGQ-------------------------------------------KEAPCRGRYRRR-------------S RSFQYCCLHDEGAGLTRATW----------------------------------GQKKHPSADHLVEIIMAESTKDTS-- ------------------------------------------------------SLQDFEVSTISPAMQRAIEGVQYIAD HLRAEDA------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFVLVCI LGS-VGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNA4_a -------------------------------------------------------------------------------- ----------------------------------------------------------------IQVAPRAR-RRRLLRD LFAH---YNRL-------------------------------------SRPVENTTDT---------------------- --VLVHFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWVK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWNPEE------------------- --YEN---VTSIRIPSEIIWRPDIVLYNN------ADGDFAVT-----HLTKAQLFYDGRIKWMPPAIYKSSCS----ID VT-------FFPFDQQSCKMKFGSWTYDRAK----IDLVSMASD----------------------------VDQMDYW- -ESGEWVIVNAVGKYNIKKYEC--------------------C-TEIYSDITYYFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSQCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMVFVTLSIIITVFVLNVHHRSPQ -THG-MPHWVRRVFLD-------------FVPKVLFMKRPP-G------------------------------------- -------------TAKQHCKKLIEMMHRPATVSEVENSSSFW-------TGLETELRQMGQVQKTIPKALTDSPSIRISS PSPPSSPLVNCNKGNQSLNANTFCQSISGQYSLLSEKKLLHGHKTAAFSSSQLSLPPTLPLGRLHNHTDEESNTIALNGR SLSVEHMFDDR-------------------------------------------KEASRPGGYRRR-------------S RSFQYCCLHDEGVGLTRTTG----------------------------------EMKKQPSADHLGETIMAESTKDTS-- ------------------------------------------------------SLQNIELSTISPAMQRAIEGVQYIAD HLRAEDS------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFILVCI LGS-VGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNA4_a -------------------------------------------------------------------------------- -------LPPLLSYLVANLCLS-----------------------------------------RTHVRPRAHAEERLLQD LFAR---YNKL-------------------------------------SRPVENTSDT---------------------- --VLVHFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWVK------------------------------------------------------------- ----------------------------------------------QEWSDYK-LRWKPED------------------- --YEN---VSSIRIPSEIIWRPDIVLYNN------ADGDFAVT-----HLTKAHLFHDGRIKWMPPAIYKSSCS----ID VT-------FFPFDQQSCKMKFGSWTYDRAK----IDLISMASD----------------------------VDQMDYW- -ESGEWVIINAVGKYNTKKYEC--------------------C-AEIYSDITYYFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSQCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMVFVTLSIVITVFVLNVHHRSPQ -THS-MPHWVRRVFLD-------------MVPRVLFMKRPP-G------------------------------------- -------------TAKQHCKKLIEMMHRPTAISATGNSLAYW-------TGLETGLRQMCQAENALPKTPCDSPSIHVCS PAPPSSPPEDCEEDDRLLKAN-------------------------------LSLPPALPLGPLRSFSQEEPNAMAPNGR SLSAEQMFDQQ-------------------------------------------GDLSQRAGHRCR-------------S RSFQYCCLHGEGPGLMAVAG----------------------------------WVKKQAPTNHPAGRVTGESTKDAS-- ------------------------------------------------------TQQDIVIPTISPAVQRAIEGVQYVAD HLRAEDA------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFVLVCI LGS-VGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNA4_a -------------------------------------------------------------------------------- ---------------------------------------------------------------SSQIEPRAHAEERLLQN LFAR---YNKL-------------------------------------SRPVQNTSDT---------------------- --VLVHFGLSIAQLIDVD-------------------------------------------------------------- -----EK-NQMMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWNDYK-LRWNPED------------------- --YEN---VTSIRIPSEIIWRPDIVLYNNH----SADGDFAVT-----HLTKAHLFYDGQIKWMPPAIYKSSCS----ID VT-------FFPFDQQSCKMKFGSWTYDRAK----IDLISMASD----------------------------VDQMDYW- -ESGEWVIVNAVGKYNTKKYEC--------------------C-AEIYADITYYFIIRR--------------------- --------------------LPLFYTINLIIPCLLISCLTVLVFYLPSQCG-------------------EKITLC---- ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMVFVTLSIIITIFVLNVHHRSPQ -THG-MPHWVRRVFLD-------------LVPRVLFMKRPP-G------------------------------------- -------------TAKQHCKRLIEMMHCPTTISATGNSQSFW-------TGLDSELRQMTQVHNSLPK--VDSPRILVCS PSPSSSPVDDCSDEDHPLKADIFCQTPSGQYSPLLEHQALCRHISTTHSAPQLSMP----LGPFPCLSREHPSPLARNGR SLSVEQMCGKQ-------------------------------------------GQPPQRSAHRCR-------------S QSFQYCCLHNDG--AAGFTG----------------------------------QTNKTP--EQLTETLAAEFAKDAS-- ------------------------------------------------------TQLDNMAPIVSPAMQRAIEGVQYIAD HLRAGDA------------------------------------------------------------------------- ----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFVLVCI LGS-VGLFLPPWLAGMI--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNA3 ------------------------------------------------------------------------------MG SGPLSLPLALSPPRLLLLLLLS-----------------------------------------LLPVARASEAEHRLFER LFED---YNEI-------------------------------------IRPVANVSDP---------------------- --VIIHFEVSMSQLVKVD-------------------------------------------------------------- -----EV-NQIMETNLWLK------------------------------------------------------------- ----------------------------------------------QIWNDYK-LKWNPSD------------------- --YGG---AEFMRVPAQKIWKPDIVLYNN------AVGDFQVD-----DKTKALLKYTGEVTWIPPAIFKSSCK----ID VT-------YFPFDYQNCTMKFGSWSYDKAK----IDLVLIGSS----------------------------MNLKDYW- -ESGEWAIIKAPGYKHDIKYNC--------------------C-EEIYPDITYSLYIRR--------------------- --------------------LPLFYTINLIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT -THT-MPSWVKTVFLN-------------LLPRVMFMTRPTSN-EGNAQKP----------------------------- ------------RPLYGAELSNLNCFSRAESKGCKEG------------------------------------------- ------------------------------------------------------------------------------YP CQDGMCG------------------------------------------------------------------------- -YCHHRRIK--------------------------------------------ISNFSANLTRSSSSESVDAVLSLS--- --------------------------------------------------------------ALSPEIKEAIQSVKYIAE NMKAQNE------------------------------------------------------------------------- ----------------------------------------------------AKEIQDDWKYVAMVIDRIFLWVFTLVCI LGT-AGLFLQPLMAREDA-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryctolagus_cuniculus_CHRNA3 -------------------------------------------------------------------------------- -----MGAPPPPPPSPVLLLLLLL---------------------------------------LPPVVSASEAEHRLFER LFED---YNEI-------------------------------------IRPVANVSDP---------------------- --VIIQFEVSMSQLVKVD-------------------------------------------------------------- -----EV-NQIMETNLWLK------------------------------------------------------------- ----------------------------------------------QIWNDYK-LKWNPSD------------------- --YNG---AEFMRVPAQKIWKPDIVLYNN------AVGDFQVD-----DKTKALLKYTGEVTWIPPAIFKSSCK----ID VT-------YFPFDYQNCTMKFGSWSYDKAK----IDLVLIGSS----------------------------MNLRDYW- -ESGEWAIIKAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR--------------------- --------------------LPLFYTINLIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT -THT-MPAWVKTVFLN-------------FLPRVMFMTRPASD-GDSAQMP----------------------------- ------------QLLAGAELSNLGCFGRTEPKACKEG------------------------------------------- ------------------------------------------------------------------------------CP CQDGACG------------------------------------------------------------------------- -YRHHRRVK--------------------------------------------MSNFGANLTRSSSLESVDAVLSLS--- --------------------------------------------------------------ALSPEIREAIRSVQYIAE NMKAQNE------------------------------------------------------------------------- ----------------------------------------------------AKEIQDDWKYVAMVIDRIFLWVFILVCI LGT-AGLFLQPLMARDDA-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Taeniopygia_guttata_CHRNA3 -------------------------------------------------------------------------------- ------------------------------------------------------------------GCGGSEAEHRLYAA LFKS---YNQF-------------------------------------VRPVKNVSDP---------------------- --VIIQFEVSMSQLVKVD-------------------------------------------------------------- -----EV-NQIMETNLWLK------------------------------------------------------------- ----------------------------------------------HIWNDYK-LRWNPAD------------------- --YGG---AEFIRVPSGQIWKPDIVLYNN------AVGDFQVD-----DKTKALLKYTGDVTWIPPAIFKSSCK----ID VT-------YFPFDYQNCTMKFGSWSYDKAK----IDLVLIGST----------------------------MNLKDYW- -ESGEWAIIKAPGYKHDIKYNC--------------------C-EEIYPDITYSLYIRR--------------------- --------------------LPLFYTINMIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK -THT-MPVWVKTIFLN-------------LLPRIMFMTRPASD-EENNQKP----------------------------- ------------KPLFTSEFSNLNCINGSETKSCKDG------------------------------------------- ------------------------------------------------------------------------------FA CQDMACS------------------------------------------------------------------------- -CCQYQR---------------------------------------------------------TNSESVDPMLSFS--- --------------------------------------------------------------VLSPEMRDAIESVKYIAE NMKMQNE------------------------------------------------------------------------- ----------------------------------------------------AKEIQDDWKYVAMVIDRIFLWVFILVCI LGT-AGLFLQPLM------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Pelodiscus_sinensis_CHRNA3 -------------------------------------------------------------------------------- QTSAPLSLPSTAFSKEVSLLILPA---------------------------------------TLSVSNCSEAEHRLFAS LFAN---YSQF-------------------------------------IRPVENVSDP---------------------- --AIIQFEVSMSQLVKVD-------------------------------------------------------------- -----EV-NQIMETNLWLK------------------------------------------------------------- ----------------------------------------------HIWNDYK-LKWNPEE------------------- --YGG---AEFIRVPSDSIWKPDIVLYNN------AVGDFQVD-----DKTKALLKYTGEVTWIPPAIFKSSCK----ID VT-------YFPFDYQNCTMKFGSWSYDKAK----IDLVLIGST----------------------------MNLKDYW- -ESGEWAIIKAPGYKHDIKYNC--------------------C-EELYPDITYSLYIRR--------------------- --------------------LPLFYTINMIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK -THT-MPEWVKTIFLN-------------LLPKIMFMTRPASD-EETTQKL----------------------------- ------------KPLYSVELSDLNCFSSSETKCCKEG------------------------------------------- ------------------------------------------------------------------------------FI CQDTACS------------------------------------------------------------------------- -CCRYQRIK--------------------------------------------FSDFSGNLTRSSSYESVDALLSLS--- --------------------------------------------------------------VLSPEIRDAIESVKYIAE NMKMQNE------------------------------------------------------------------------- ----------------------------------------------------AKEIQDDWKYVAMVIDRIFLWVFILVCI LGT-AGLFLQPLMTRDEI-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNA3_a -------------------------------------------------------------------------------- --------MQLIHFIIASTIQLCV---------------------------------------SVSGVCCSEAEHRLFSV IFSS---YNQY-------------------------------------IRPVENVSDP---------------------- --VVVQFEVSMSQLVKVD-------------------------------------------------------------- -----EV-NQIMETNLWLR------------------------------------------------------------- ----------------------------------------------HIWNDYK-LRWDPKD------------------- --FGG---VEFIRVPSNKIWKPDIVLYNN------AVGDFQVD-----DKTKALLRFNGDVTWIPPAIFKSSCK----ID VT-------YFPFDYQNCTMKFGSWTYDKAK----IDLVLIGST----------------------------INLKDFW- -ESGEWTIIDAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR--------------------- --------------------LPLFYTINMIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK -THT-MPCWVRRVFLS-------------LLPRVMFMTRPEKDQEVPAKH---------KQTSVCRG------------- --------------------PQLLLCPTELNEASRTA------------------------------------------- ------------------------------------------------------------------------------FL CREHHCW------------------------------------------------------------------------- -KKHISNMT-------------------------------------------SEGAEDGGSPCSSSESLDG-FLCMS--- --------------------------------------------------------------AVSPQVREAIESVKYIAE NMRLQNE------------------------------------------------------------------------- ----------------------------------------------------AKEVQDDWKYVAMVIDRIFLWVFVLVCI LGT-AGLFLQPLLLGEDM-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNA3_a -------------------------------------------------------------------------------- ---------------------LLF---------------------------------------LLPGGCCSEAEHKLFSV IFSN---YNQY-------------------------------------IRPVENVTDP---------------------- --VIVQFEVSMSQLVKVD-------------------------------------------------------------- -----EV-NQIMETNLWLR------------------------------------------------------------- ----------------------------------------------HIWNDYK-LRW-PKE------------------- --YGG---VEYIRVPSSRIWKPDIVLYNN------AVGDFQVD-----DKTKALLRYNGDVTWIPPAIFKSSCK----ID VT-------YFPFDYQNCTMKFGSWTYDKAK----IDLVLIGST----------------------------MNLKDFW- -ETGDWLIIDAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR--------------------- --------------------LPLFYTINLIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK -THT-MPCWVRAVFLE-------------LLPRVMFMTRPERHAFQVLRRP----------------------------- --------------LSNTELSNLNNLSGDPSKGSTS-------------------------------------------- -------------------------------------------------------------------------------L CCEGRCN------------------------------------------------------------------------- -CCWYQRSR------------------------------------------GSVAKVSGGSQRSSSESLNGGLMPLL--- --------------------------------------------------------------PLSPEVREAIESVRYIAE NMRLQNE------------------------------------------------------------------------- ----------------------------------------------------AKEVQDDWKYVAMVIDRIFLWVFVLVCI LGT-AGLFLQPLLLAEDI-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNA3_a -------------------------------------------------------------------------------- ---------------------LLF---------------------------------------RLPGGSCSEAEHKLFSV IFSN---YNQY-------------------------------------IRPVENVTDP---------------------- --VIVQFEVSMSQLVKVD-------------------------------------------------------------- -----EV-NQIMETNLWLR------------------------------------------------------------- ----------------------------------------------HIWNDYK-LRWNPKE------------------- --YGG---VEYIRVPSSRIWKPDIVLYNN------AVGDFQVD-----DKTKALLRYNGDVTWIPPAIFKSSCK----ID VT-------YFPFDYQNCTMKFGSWTYDKAK----IDLVLIGST----------------------------MNLKDFW- -ETGDWLIIDAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR--------------------- --------------------LPLFYTINLIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK -THT-MPRWVRAVFLE-------------LLPRVMFMIRPEREPEQGRGAG-NAQDMHPRSCSVHSS------------- ------------------ELSNLNNLSGDLTKGSTS-------------------------------------------- -------------------------------------------------------------------------------L CCEGRCN------------------------------------------------------------------------- -CCWYQRS-----------------------------------------------KVSGGSQCSSSDSLNGGLMPQL--- --------------------------------------------------------------PLSPEVREAIESVRYIAE NMRLQNE------------------------------------------------------------------------- ----------------------------------------------------AKEVQDDWKYVAMVIDRIFLWVFVLVCI LGT-AGLFLQPLLLAEDI-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNA3_a -------------------------------------------------------------------------------- ------------------------------------------------------------------------AEHKLFSV IFSS---YNQY-------------------------------------IRPVENVTDP---------------------- --VVVQFEVSMSQLVKVD-------------------------------------------------------------- -----EV-NQIMETNLWLR------------------------------------------------------------- ----------------------------------------------HIWNDYK-LRWNPKD------------------- --FGG---VDFIRVPSNRIWKPDIVLYNN------AVGDFQVD-----DKTKALLRFNGDVTWIPPAIFKSSCK----ID VT-------YFPFDYQNCTMKFGSWTYDKAK----IDLVLIGST----------------------------INLKDFW- -ESGEWTIIDAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR--------------------- --------------------LPLFYTINMIIPCLLISFLTVLVFYLPSDCG-------------------EKITLC---- ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK -THT-MPCWVRTVFLG-------------LLPRVMFMTRPETDAERVLAAAGDVQTTHLRPCAIHPSGALQKQHKPQAPP PPSVVSSLTNRQRLFNNTELSDLNNLSGDPAKGAGSA------------------------------------------- ------------------------------------------------------------------------------LL CCKGHCN------------------------------------------------------------------------- -CCWRQRSSKLPADSGGGSGGLG---------------------SMG--ALSGGSAVGGGSHCSSSESVAGGTMSML--- --------------------------------------------------------------PLSPEVQEAIESVKYIAE NMRLQNE------------------------------------------------------------------------- ----------------------------------------------------AKEVQDDWKYVAMVIDRIFLWVFVLVCI LGT-AGLFLQPLLLWDDI-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNB4 -------------------------------------------------------------------------------- --------------------------MRRAPSLVLFFL---------------------VALCGRGNCRVANAEEKLMDD LLNKTR-YNNL-------------------------------------IRPATSSSQL---------------------- --ISIKLQLSLAQLISV-N------------------------------------------------------------- -----ER-EQIMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWTDYR-LTWNSSR------------------- --YEG---VNILRIPAKRIWLPDIVLYNN------ADGTYEVS-----VYTNLIVRSNGSVLWLPPAIYKSACK----IE VK-------YFPFDQQNCTLKFRSWTYDHTE----IDMVLMTPT----------------------------ASMDDFT- -PSGEWDIVALPGRRTVNPQ------------------------DPSYVDVTYDFIIKR--------------------- --------------------KPLFYTINLIIPCVLTTLLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTFFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPS -THT-MAPWVKRCFLH-------------KLPTFLFMKRPG--------------------------------------- -------------PDSSPARAFPPSKSCVTKPEATATS------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------TSPSNFYGNSMYFVNPASAAS--- ------KSPAGSTP-VA---------------------------------IPRDFWLR-SSGRFRQDVQEALEGVSFIAQ HMKND-DEDQSVV------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVVDRLFLWVFMFVCV LGT-VGLFLPP--LFQTHAASEGPYAAQRD-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNB4_b -------------------------------------------------------------------------------- ------------------------------------------------------------------XGVCADSEERLMNW LLGKHR-YNKL-------------------------------------IRPALNRTER---------------------- --VTVLLQVSLAQLISV-N------------------------------------------------------------- -----ER-EQIMTTNVWLT------------------------------------------------------------- ----------------------------------------------QNWNDYR-LSWDPAE------------------- --YEG---IDKLRIPSRHIWLPDIVLYNN------ADGTYEVT-----VFTNAIVLFNGSIAWLPPAIYKSACK----IE VK-------HFPFDQQNCTLKFRSWTYDHTE----IDLLLKSDA----------------------------ASMDDFT- -PSGEWDILALPGRRTVSPL------------------------DATYVDLTYDFIIKR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPS -THS-MPAWVKIVFLV-------------RLPALLFMQR----------------------------------------- -------------PRGHSARQRLRQNRRLLGLADTPGRSVMC-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------SSASALLAASSASALSSPGLLYNKGHFGSRR- -----AEGLNNGHG------------------------------------SAQDLKGNRLYCEWGSEIQEAVDGVRYVAD HMMGN-DDDQSVI------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVVDRLFLWIFVIVCV VGT-LGLFLQP--LFQNQTLAIQQPNTEPARRDGM--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNB4_a -------------------------------------------------------------------------------- -----------------------------LWGRLMTVLS----------------LNSLIYHGVPSGCRCADSEERLMNW LLGKNR-YNPL-------------------------------------IRPASNRTER---------------------- --VPVKLQVSLAQLISV-N------------------------------------------------------------- -----ER-EQIMTTNLWLM------------------------------------------------------------- ----------------------------------------------QHWVDYR-LSWDPAK------------------- --YEG---INKLRIPSRLIWLPDIVLYNN------ADGTYEVT-----VFTNAIVLFNGSINWLPPAIYKSACK----IE VK-------HFPFDQQNCTLKFRSWTYDRTE----IDLVLKTDA----------------------------ASMDDFT- -PSGEWDILALPGRRTVNPL------------------------DPTYVDLTYDFIIKR--------------------- --------------------KPLFYTINLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPS -THT-MPSWVKLIFLV-------------KLPSLLFIRR----------------------------------------- -------------PQNNSARQRLQSQRCQRAKRDILG------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------LGCQ--PKSSITMLSSALLSPGSVFSTPG- -----QKNVAPSLS----------------------------------LNITQNLQQS-SGADWAADVQEALSGVRFVAE HMMED-DDDQSVI------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVVDRMFLWIFVIVCV VGT-LGLFLQP--VFQNPITPIQQPSSDM--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNB4_a -------------------------------------------------------------------------------- -------------------------------FGCEYTTC----------------AFKLWNINVSPGSRCAESEERLMNW LLGKDR-YNLL-------------------------------------IRPAVNRTER---------------------- --VPVKLQVSLAQLISV-N------------------------------------------------------------- -----ER-EQIMTTNVWLT------------------------------------------------------------- ----------------------------------------------QHWVDYR-LSWDPAK------------------- --YEG---IDKLRIPSRHIWLPDIVLYNN------ADGTYEVT-----VFTNAIVIFNGSINWLPPAIYKSACK----IE VK-------HFPFDQQNCTLKFRSWTYDHTE----IDLILKSEV----------------------------ASMDDFT- -PSGEWDILALPGRRTVNPL------------------------DPTYVDLTYDFIIKR--------------------- --------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPS -THT-MPSWVKLIFLV-------------KLPALLFMRR----------------------------------------- -------------PQNNSASQRLRRQRCLRARKSIGS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------SGYPDAAKTGFILSPSALKG------DLR- -----STDYIPSGQ---------------------------------------DLKQS-TSSDWAADVQEAVNGVRFVAE HMMGD-DDDQSVI------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVVDRMFLWIFVIVCV VGT-LGLFLQP--VFQTQIVPNQQ-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNB4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------CKSADSEERLMNM LLGKHR-YNPL-------------------------------------IRPAINRTER---------------------- --VEVKLQVSLAQLISV-N------------------------------------------------------------- -----ER-EQIMTTNVWIT------------------------------------------------------------- ----------------------------------------------QHWVDYR-LSWDPAK------------------- --YEG---IQKLRIPSRHVWLPDIVLYNN------ADGIYEVT-----VFTNVIVLFNGSVNWLPPAIYKSACK----IE VK-------HFPFDLQNCTLKFRSWTYDHTE----IDLILKSEA----------------------------ASMDDFT- -PSGEWDIIALPGRRTVNPT------------------------DPTYVDLTYDFIIKR--------------------- --------------------KPLFYTINLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC---- ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPS -THT-MPSWVKLIFLK-------------KLPALLFMKR----------------------------------------- -------------PNNFSGCQRLRQQRCLRARRSILG------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------LDYPNASKACFTLSSSALLPSDSAFSTPR- -----HKNLAPTMGYGLSRRKGDLSSSD---------------YPHISLTPTQDYQQK-CKSDWTADVKEAVKGVRFVAE HMMAD-DDDQSVI------------------------------------------------------------------- ---------------------------------------------------------EDWKYVAMVVDRMFLWIFVIVCV VGT-LGLFLQP--LFQSQMITSQQPSSDKPRI------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Trichoplax_adhaerens_CHRNB4 --------MVATAQKNCYIYAILFASILSHSICNAQKTLFSVLEQQQTQNAVMISTNGDAIIAGLLPAHYNYEDGKHKCS ELDTYGIHLMMAMIFAINDINEQSNLLPDVKLGYDIRDTCHN-------------SLRVSKEIMALLMQYLPFKEGKYDG FFCEKIKYDEANEETVRTYGPIIGVIGTTMSDSTIATANTIGNFGVIEITPSALAVTQSDNQPPNLYSTQPSFYDHLVVI SKIIIALDMTRICLITIEPPETSYRMDLLRTILQDAKICIAQEFSITGDRMSLAMARVIQNLKANNKLQVVVLLGPYEKG VRFMKEAERQNLTGRTWIG------------------------------------------------------------- ---------------------------------------------AGEWVKSPAIYSIRKEVMGGLLAVSTQTFRSVLIT KHLENYVTSDTRNVHLDQLWKKLYNCTPNEENCEVRLGSYEIIDEKKSSCEYYQSELNEDIIYVIDAVYAIAHALHQTLN CTIEFCN-SVETFNHTIFNYHLQRVEFSNHAN-QPVEFQQNKGVRHILIQN-------------------LHHDDNCSHF VEVARWNPFESEMIMDTNKIRWRNGESTTIPTEVYETACTPGDRKHSFDQESCYYVCLKCGPSLVSNGTTSQCFKCSPGF KPTNNRSACQEIPPTKLDWRNPVNLTILIFTLLSMLTLLFIVIIFFKYSNTP-----------------IVKASNKI--- MSHIQLLSVALLFILGG-------------SYQFAVTTSLCWFQFAICSVSFPLCEACLLAKTKHVANVFTLSSRIQKVD KSSRLQSRWCKSLIPILFVLS------ITAIPIIIWLIFTIID------------------------------------- -------------PPNAIPDYRYENEVHILCSSKLHLG------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------LGLVVGFTLVLAIICTILAWKTRKLP-- ----------------------------------------------------------DNFSEARYIFICSFSTLVIVAL SVPGYYSTVG---------------------------------------------------------------------- --------------------------------------------------------LLQATFASIAVITFGLSILLLLFI PKIYTILFRPDLNTKEAMLRSIQEFTFGADTRIHTKPK------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNB1 -------------------------------------------------------------------------------- --MTPGAL--LMLLGALGAPLAP-------------------------------------------GVRGSEAEGRLREK LFSG---YDSS-------------------------------------VRP-AREVGDR--------------------- --VRVSVGLILAQLISLN-------------------------------------------------------------- -----EK-DEEMSTKVYLD------------------------------------------------------------- ----------------------------------------------LEW-TDYRLSWDPAE------------------- --HDG---IDSLRITAESVWLPDVVLLNN------NDGNFDVA-----LDISVVVSSDGSVRWQPPGIYRSSCS----IQ VT-------YFPFDWQNCTMVFSSYSYDSSE----VSLQTGLGPDGQGHQEIH-------------------IHEGTFI- -ENGQWEIIHKPSRLIQPPGDPR------------------GGREGQRQEVIFYLIIRR--------------------- --------------------KPLFYLVNVIAPCILITLLAIFVFYLPPDAG-------------------EKMGLS---- IFALLTLTVFLLLL----------------------ADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPH --THQMPLWVRQIFIH-------------KLPLYLRLKRPKPERDLMPEPPHCS---SPGSG------------------ ------------WGRGTDEYFIRKP-PSDFLFPKPNR------------------------------------------- -------------------------------------------------------------------------------- FQP----------------------------------------------------------------------------- --------------------------------------------------------ELSAPDLRRFIDGPNRAVALLP-- ------------------------------------------------------------------ELREVVSSISYIAR QLQEQEDHD----------------------------------------------------------------------- ------------------------------------------------------ALKEDWQFVAMVVDRLFLWTFIIFTS VGT-LVIFLDATYHLPPPDPFP---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gorilla_gorilla_CHRNB1 -------------------------------------------------------------------------------- ----MTPGALLMLLGALGAPLAP-------------------------------------------GVRGSEAEGRLREK LFSG---YDSS-------------------------------------VRP-AREVGDR--------------------- --VRVSVGLILAQLISLN-------------------------------------------------------------- -----EK-DEEMSTKVYLD------------------------------------------------------------- ----------------------------------------------LEW-TDYRLSWDPAE------------------- --HDG---IDLLRITAESVWLPDVVLLNN------NDGNFDVA-----LDISVVVSSDGSVRWQPPGIYRSSCS----IQ VT-------YFPFDWQNCTMVFSSYSYDSSE----VSLQTRLGPDGQGHQEIH-------------------IHEGTFI- -ATS--------SLTSYLPG--------------------------------QYIIVIE--------------------- --------------------KSVFEWP-----GNMITDYAIELSFSSALQG-------------------EKMGLS---- IFALLTLTVFLLLL----------------------ADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPH --THQMPLWVRQIFIH-------------KLPLYLRLKRPKPERDLMPEPPHCS---SPGSD------------------ ------------WGRGTDEYFIRKP-PSDFLFPKPNR------------------------------------------- -------------------------------------------------------------------------------- FQP----------------------------------------------------------------------------- --------------------------------------------------------ELPAPDLRRFIDGPNRAVALLP-- ------------------------------------------------------------------ELREVVSSISYIAR QLQEQEDHD----------------------------------------------------------------------- ------------------------------------------------------ALKEDWQFVAMVVDRLFLWTFIIFTS VGT-LVIFLDATYHLPPPDPFP---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Mus_musculus_CHRNB1 -------------------------------------------------------------------------------- ----MALGALLLLLGVLGTPLAP-------------------------------------------GARGSEAEGQLIKK LFSN---YDSS-------------------------------------VRP-AREVGDR--------------------- --VGVSIGLTLAQLISLN-------------------------------------------------------------- -----EK-DEEMSTKVYLD------------------------------------------------------------- ----------------------------------------------LEW-TDYRLSWDPAE------------------- --HDG---IDSLRITAESVWLPDVVLLNN------NDGNFDVA-----LDINVVVSFEGSVRWQPPGLYRSSCS----IQ VT-------YFPFDWQNCTMVFSSYSYDSSE----VSLKTGLDPEGEERQEVY-------------------IHEGTFI- -ENGQWEIIHKPSRLIQLPGDQR------------------GGKEGHHEEVIFYLIIRR--------------------- --------------------KPLFYLVNVIAPCILITLLAIFVFYLPPDAG-------------------EKMGLS---- IFALLTLTVFLLLL----------------------ADKVPETSLAVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPH --THQMPFWVRQIFIH-------------KLPPYLGLKRPKPERDQLPEPHHSL---SPRSG------------------ ------------WGRGTDEYFIRKP-PSDFLFPKLNR------------------------------------------- -------------------------------------------------------------------------------- FQP----------------------------------------------------------------------------- --------------------------------------------------------ESSAPDLRRFIDGPTRAVGLPQ-- ------------------------------------------------------------------ELREVISSISYMAR QLQEQEDHD----------------------------------------------------------------------- ------------------------------------------------------ALKEDWQFVAMVVDRLFLWTFIVFTS VGT-LVIFLDATYHLPPPEPFP---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNB1_a -------------------------------------------------------------------------------- ------MKAQDWIIVTCCLCGLGA------------------------------------------MTGATEMEDKLMKK LFSA---YNSK-------------------------------------VRP-ARNPEER--------------------- --VVVRIGMILSSFVSLN-------------------------------------------------------------- -----MK-DEEMNTIVMMN------------------------------------------------------------- ----------------------------------------------LEW-NDYRLSWNPKD------------------- --YGG---VDVLRISSGKVWLPDIVLINN------NDGVFGVA-----LQVHVQAYSNGRVTWTPPALYKSSCG----VK VT-------YFPFDWQNCTMVFRSYTYDSSE----VDLQHALDKRGKEIKEII-------------------LDTGFS-- -ESGEWHIRHKVSRKNVR--------------------------EDLYEDITFYLIIER--------------------- --------------------KPMFYVVNIVLPCILITIIAIFNFYLPPDAG-------------------EKMGLS---- INVLLTLTVFLLLL----------------------ANKIPETSLGVPIIVNYLMITMILVTFSVILSVVVLNLHHRSPN --THQMPLWVRKIFIH-------------MLPPYLGMLRPKVETPLFLEKPAKKE---NIQA------------------ ------------ISRVADEYFIRKPSNMNFLFPKPHR------------------------------------------- -------------------------------------------------------------------------------- YQP----------------------------------------------------------------------------- --------------------------------------------------------DGQCTDLRKFIDGPSHYLTLPP-- ------------------------------------------------------------------ELKTAVEAITYIAE QLQAEKDYE----------------------------------------------------------------------- ------------------------------------------------------ALKEDWQYVAMVADRLFLWIFVIFTT LGT-LGIFTDASFNATPTDPFP---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNB1_a -------------------------------------------------------------------------------- ----STMKYLLLLPLSCCLCSLIP------------------------------------------LGGASEVEKTLMKT LFSN---YTLK-------------------------------------VRP-AISPEQR--------------------- --VVVRVGMILSSFVGLN-------------------------------------------------------------- -----MK-NEEMSTIVVMN------------------------------------------------------------- ----------------------------------------------LEW-TDYRLSWSPKQ------------------- --YGG---IEVLRIPSGKVWLPDIVLINN------NDGVFHVA-----LHVHVQVYSNGRVTWTPPALYCSSCG----VK VE-------YFPFDWQNCSMQFRSYTYDSTE----IDVQYALNLRGQEIREIQ-------------------LDEAFT-- -EGGEWYIKHRPSRKVML--------------------------DDEYEGMVFYLIIER--------------------- --------------------KPLYYVLNIILPCILITIIAIFNFYLPPDAG-------------------EKMGLS---- INVLLTLTVFLLLL----------------------ADKIPETSLGVPIIVNYIMLTMILVTFSVILSVVVLNLHHRSPN --THQMPMWVRKIFIH-------------LLPPYLCMMRPKVEAPLYLEALPRREK--KVTT------------------ ------------VSKVADEYFIRKP-DMSVLFPKPNR------------------------------------------- -------------------------------------------------------------------------------- FHS----------------------------------------------------------------------------- --------------------------------------------------------EGLCTDLRKFIDGPSSYLSLPE-- ------------------------------------------------------------------ELKSAIEAITYIAE ALQAEKDYE----------------------------------------------------------------------- ------------------------------------------------------ALKKDWQYVAMVVDRMFLWIFVIFTT VGT-LAIFAEASFNRAPANPFP---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNB1_b -------------------------------------------------------------------------------- ------TSYLLFTQL--IFGVLLL------------------------------------------LAGASEVEKTLMKT LFSN---YTLK-------------------------------------VRP-AISPEQR--------------------- --VVVRVGMILSSFVGLN-------------------------------------------------------------- -----MK-NEEMSTIVVMN------------------------------------------------------------- ----------------------------------------------LEW-TDYRLSWSPKQ------------------- --YGG---IEVLRIPSGKVWLPDIVLINN------NDGVFHVA-----LHVHVQVYSNGRVTWTPPALYCSSCG----VK VE-------YFPFDWQNCSMQFRSYTYDSTE----IDVQYALNLRGQEIREIQ-------------------LVYNISP- -EGGEWYIKHRPSRKVML--------------------------DDEYEGMVFYLIIER--------------------- --------------------KPLYYVLNIILPCILITIIAIFNFYLPPDAG-------------------EKMGLS---- INVLLTLTVFLLLL----------------------ADKIPETSLGVPIIVNYIMLTMILVTFSVILSVVVLNLHHRSPN --THQMPMWVRKIFIH-------------LLPPYLCMMRPKVEAPLYLEALPRREK--KVTT------------------ ------------VSKVADEYFIRKP-DMSVLFPKPNR------------------------------------------- -------------------------------------------------------------------------------- FHS----------------------------------------------------------------------------- --------------------------------------------------------EGLCTDLRKFIDGPSSYLSLPE-- ------------------------------------------------------------------ELKSAIEAITYIAE ALQAEKDYE----------------------------------------------------------------------- ------------------------------------------------------ALKKDWQYVAMVVDRMFLWIFVIFTT VGT-LAIFAEASFNRAPANPFP---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNB1_b -------------------------------------------------------------------------------- ---------------------------------------------------------------------AFEVESALLKN LFSN---YTLK-------------------------------------VRP-AVSPEQR--------------------- --VVVRVGMILSSFVGLN-------------------------------------------------------------- -----MK-NEEMSTIVVMN------------------------------------------------------------- ----------------------------------------------LEW-TDYRLSWSPKD------------------- --YDG---IEVLRIPSGKIWLPDIVLINN------NDGVFEVA-----LQVHVQVYSNGRVTWTPPALYCSSCG----VK VE-------YFPFDWQNCSMQFRSYTYDSTE----IDIQYALDSKGREIKEIQ-------------------LDEAYT-- -EGGEWYIKHRPSRKVML--------------------------DDEYEGMVFYLIIER--------------------- --------------------KPLYYVLNIILPCILITIIAIFNFYLPPDAG-------------------EKMGLS---- INVLLTLTVFLLLL----------------------ADK-PETSLGVPIIVNYIMFTMILVTFSVILSVVVLRLHHRSHN --THQMPMWVRRIFIH-------------LLPPYLCMMRPQVETPLYLEVLPRREK--KIPA------------------ ------------SSKVADEYFIRKP-DLSVLFPKPNR------------------------------------------- -------------------------------------------------------------------------------- FHS----------------------------------------------------------------------------- --------------------------------------------------------DGLCTDLRKFIDGPSSYLSLPE-- ------------------------------------------------------------------ELKSAIEAITYIAE ALQAEKDYE----------------------------------------------------------------------- ------------------------------------------------------ALKKDWQYVAMVVDRMFLVLFVIFTT VGT-LAIFTQASFNRSPGNPFPVTPDTWFL-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNB1_a -------------------------------------------------------------------------------- ---------------------PLC------------------------------------------PTGASDMEKTLLKK LFTD---YNLK-------------------------------------VRP-ASSPEER--------------------- --VVVRVGMVLSSFVGLN-------------------------------------------------------------- -----MK-NEEMSTIVVMN------------------------------------------------------------- ----------------------------------------------LEW-TDHRLSWKREE------------------- --YDG---IEVMRIPAGKVWLPDIVLINN------NDGVFDVA-----LHVHVQAYSNGRVTWTPPALYCSSCG----VK VT-------YFPFDWQNCTMQFQSYTYDSTE----IDVQYALDSKRNEIREIQ-------------------LDEAYT-- -EGGEWTIKHKPCRKNMN--------------------------DDQYEVMTFYLIIER--------------------- --------------------KPLYYVLNIILPCILITIIAIFNFYLPPDAAPG-----------------EKMGLS---- INVLLTLTVFLLLL----------------------ADKIPETSLGVPIIVNYIMFTMILVTFSVILSVVVLNLHHRSPS --THMMPMWVRKIFIH-------------LLPPYLYMLRPKVETPLSLEFMPRREK--KVFT------------------ ------------ISK-ADEYFIRKP-DSSILFPKPNR------------------------------------------- -------------------------------------------------------------------------------- FHP----------------------------------------------------------------------------- --------------------------------------------------------EGMCTDLRKYIDGPSSYLTLPD-- ------------------------------------------------------------------ELKSAIEAITFIAE ALQAEKDFE----------------------------------------------------------------------- ------------------------------------------------------ALREDWQYVAMVVDRMFLWIFVIFTT VGT-LAIFADASFHRTPTDPFK---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNB1_a -------------------------------------------------------------------------------- -------MTLLFPVGHLGVPYRSR------------------------------------------LLGAAQVEQALMKS LFSD---YNLK-------------------------------------VRP-AHVPESR--------------------- --VVVRVGMILSSFVGLN-------------------------------------------------------------- -----MK-NEEMSTTVVMN------------------------------------------------------------- ----------------------------------------------LEW-TDYRLTWNPKQ------------------- --HDG---IKMLRVPSGKVWLPDIVLINN------NDGVFDVA-----LRVHVLVYSDGRITWTPPALYLSSCG----VK VT-------YFPFDWQNCTMQFRSYTYDSTE----IDLQYALDSKGKEIREIQ-------------------LDEGFS-- -ESGEWHIRHKPSRKIMK--------------------------DDLYEEMTFYLIIER--------------------- --------------------KPLY-----------------FNFYLPPDAG-------------------EKMGLS---- INVLLTLTVFLLLL----------------------ADKIPETSLGVPIIVKYIMFTMILVTCSVILSVVVLNLHHRSPN --THMMPMWIRKIFLH-------------MLPPYLFMRRPKQENLQYLESVPRREM--KVMA------------------ ------------ISKAADEYFIRKP-DSSILFPKPNR------------------------------------------- -------------------------------------------------------------------------------- FHS----------------------------------------------------------------------------- --------------------------------------------------------DGMYTDLRKFIDGPSTYLALPD-- ------------------------------------------------------------------ELKTAIDAITYIAE ALQAEKDYE----------------------------------------------------------------------- ------------------------------------------------------ALKEDWQFVAMVVDRMFLWIFVVFTT LGT-LAIFIDASFNHTPKDPFK---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Ciona_intestinalis_CHRNB1 -------------------------------------------------------------------------------- -------MINCLLIFLLLPITKTS------------------------------------------AAKFESTEGRLANY LLNG---YNPQ-------------------------------------FRPYNKKYENK--------------------- --TFVDVMMTLSQIISVK-------------------------------------------------------------- -----EK-SQEFTTSVYMQ------------------------------------------------------------- ----------------------------------------------YDW-LDDRFGWVPDD------------------- --YDG---ITTVRIPCASIWVPRIVLQNS------IDGNFDVS-----LRTNALIQHDGKVSWLPPALYKSTCT----IE VA-------LFPFDWQNCTMVFRSATYDRTE----MEFGIPI-DTVYIDLSA-------------------------FQ- -SNGEWDILQRPVKINSNEN------------------------DKTYQDITFYFIIRR--------------------- --------------------KPQFYIINLIIPCILMSSLSCFVFYLPSISC-------------------EKMTLS---- ISILLGETVFLFLI----------------------AQRMPETSLAVPLIAGYLLFVMILVIISVICSVVVCNVHYRSNT --THSMPDWIVWIFME-------------KLAPLLKVERPSEEESGACSARPR----RCSSVS----------------- ------------TRKAMKQRSEWKP-PSEILFDHQAS------------------------------------------- -----------------------------------------------------------------------------RLG FRARHYLNEYGMTGI----------------------------------------------------------------- --------------------------------------------------------NVAAPENGSFVPPSFKKLPKG--- -------------------------------------------------------------------FQPAADSIDYIAN QKKEENEMG----------------------------------------------------------------------- ------------------------------------------------------QSQDDWGYVALILDRLLLWVYLATFT LGT-LFFFLQTKFAYYPEKLN----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNE -------------------------------------------------------------------------------- MARAPLGVLLLLGLLGRG-VGKNE-------------------------------------------------ELRLYHH LFN---NYDPG-------------------------------------SRPVREPEDT---------------------- --VTISLKVTLTNLISLNE------------------------------------------------------------- -----K--EETLTTSVWIG------------------------------------------------------------- ----------------------------------------------IDWQDYR-LNYSKDD------------------- --FGG---IETLRVPSELVWLPEIVLENN------IDGQFGVA-----YDANVLVYEGGSVTWLPPAIYRSVCA----VE VT-------YFPFDWQNCSLIFRSQTYNAEE----VEFTFAVDNDGK-------------------TINKIDIDTEAYT- -ENGEWAIDFCPGVIRRHHGGA-------------------TDGPG-ETDVIYSLIIRR--------------------- --------------------KPLFYVINIIVPCVLISGLVLLAYFLPAQ-AGG-----------------QKCTVS---- INVLLAQTVFLFLI----------------------AQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQR-TP TTHA-MSPRLR----HVL---------LELLPRLLGSPPPP-EAPRAASPP----------------------------- --------------------RRASSVGLLLRAEELIL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KKPRSELVFEGQRHRQGT-------- ---------------------------------------------------WT-AAFCQSLGAAAPEVRCCVDAVNFVAE STRDQEATGEEVS------------------------------------------------------------------- ----------------------------------------------------------DWVRMGNALDNICFWAALVLFS VGSSLIFLGAYFNRVPDLPYAPCIQP------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Mus_musculus_CHRNE -------------------------------------------------------------------------------- MAGALLGALLLLTLFGRS-QGKNE-------------------------------------------------ELSLYHH LFD---NYDPE-------------------------------------CRPVRRPEDT---------------------- --VTITLKVTLTNLISLNE------------------------------------------------------------- -----K--EETLTTSVWIG------------------------------------------------------------- ----------------------------------------------IDWHDYR-LNYSKDD------------------- --FAG---VGILRVPSEHVWLPEIVLENN------IDGQFGVA-----YDSNVLVYEGGYVSWLPPAIYRSTCA----VE VT-------YFPFDWQNCSLIFRSQTYNAEE----VEFIFAVDDDGN-------------------TINKIDIDTAAFT- -ENGEWAIDYCPGMIRRYEGGS-------------------TEGPG-ETDVIYTLIIRR--------------------- --------------------KPLFYVINIIVPCVLISGLVLLAYFLPAQ-AGG-----------------QKCTVS---- INVLLAQTVFLFLI----------------------AQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLR-TP TTHA-TSPRLR----QIL---------LELLPRLLGSSPPP-EDPRTASPA----------------------------- --------------------RRASSVGILLRAEELIL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KKPRSELVFEGQRHRHGT-------- ---------------------------------------------------WT-AALCQNLGAAAPEIRCCVDAVNFVAE STRDQEATGEELS------------------------------------------------------------------- ----------------------------------------------------------DWVRMGKALDNVCFWAALVLFS VGSTLIFLGGYFNQVPDLPYPPCIQP------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Bos_taurus_CHRNE -------------------------------------------------------------------------------- MAGALLCALLLLQLLGRG-EGKNE-------------------------------------------------ELRLYHY LFD---TYDPG-------------------------------------RRPVQEPEDT---------------------- --VTISLKVTLTNLISLNE------------------------------------------------------------- -----K--EETLTTSVWIG------------------------------------------------------------- ----------------------------------------------IDWQDYR-LNYSKGD------------------- --FGG---VETLRVPSELVWLPEIVLENN------IDGQFGVA-----YEANVLVSEGGYLSWLPPAIYRSTCA----VE VT-------YFPFDWQNCSLVFRSQTYNAEE----VEFVFAVDDEGK-------------------TISKIDIDTEAYT- -ENGEWAIDFCPGVIRRHDGDS-------------------AGGPG-ETDVIYSLIIRR--------------------- --------------------KPLFYVINIIVPCVLISGLVLLAYFLPAQ-AGG-----------------QKCTVS---- INVLLAQTVFLFLI----------------------AQKTPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLR-TP TTHA-MSPRLR----YVL---------LELLPQLLGSGAPP-EIPRAASPP----------------------------- --------------------RRASSLGLLLRAEELIL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KKPRSELVFEQQRHRHGT-------- ---------------------------------------------------WT-ATLCQNLGAAAPEIRCCVDAVNFVAS STRDQEATGEEVS------------------------------------------------------------------- ----------------------------------------------------------DWVRMGKALDSICFWAALVLFL VGSSLIFLGAYFNRVPQLPYPPCM-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNE_a ----------------------------------------------------------------------------MAVA ERFGRTCVVAIALLATVLQVTGNE-------------------------------------------------ESQLIAD KFK---NYSKN-------------------------------------IRPARHADEK---------------------- --VKVQVKLTLTNLISLNE------------------------------------------------------------- -----K--EETLTTNVWIE------------------------------------------------------------- ----------------------------------------------IQWHDYR-LAWNTSE------------------- --YHD---IEQIRVPYYTVWLPDIVLENN------IDGKFDVA-----YYANVLISSDGSMYWLPPAIYRSTCA----IE IT-------YFPFDWQNCTLVFRSQTYSANE----IDIVLAEDENGK-------------------PIEWVDIDPEAFT- -ENGEWAIKHRPARKLTNQRYS-------------------PDDLE-YQEVYYNIIIQR--------------------- --------------------KPLFYVINIILPCSLISSLVVLAYFLPAK-AGG-----------------QKLTVS---- ISVLLAQTVFLILI----------------------SQKIPETSLSVPLIGKYLIFVMSMTTLIVTNCIIVLNYSLR-SP STHN-MSQSIK----HIF---------LEVVPRYLGMAPFVDEGDQ-GGVYE---------------------------- -----------------MRERRRSSFGLMQRAEEYVL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KQPRSEMMFDKQRERHGLMRTI---- ---------------------------------------------VDEIDVSSTANLYKSLAKTAPEIKECVDACNFIAE STKQQNDTGSEME------------------------------------------------------------------- ----------------------------------------------------------SWVLIGKMIDKVCFWAAISLFS IGTIAIFLMGHYNQAPEYPFAWENKKYVPE-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNE_a -------------------------------------------------------------------------------- ---SLLGSQSLVS--LFRAVQSNE-------------------------------------------------ETELIKD LFK---DYNKN-------------------------------------IRPVVHPEDK---------------------- --VEVQIKLTLTNLISLNE------------------------------------------------------------- -----K--EETLTTNVWIE------------------------------------------------------------- ----------------------------------------------IQWLDYR-LSWNESK------------------- --YYG---IQVIRVPCKTVWLPDIVLENN------IDGKFDVA-----YYANVLISSNGWMYWLPPAIYRSTCS----IE IT-------YFPFDYQNCTLAFRSQTYSANE----VDLILALTEENG-------------------TIEWVDIDPEAFT- -ENGEWAIVHRPARKMVNMRYS-------------------PDDLE-YQEILFNLVIQR--------------------- --------------------KPLFYIINLILPCSLISSLVVLAYFLPAQ-AGG-----------------QKLTVS---- ISVLLAQTVFLFLI----------------------AQKVPETSLSVPLIGKYLIFVMCVTTLIATNQIVVLNFSLR-SP NTHT-MSQTIK----HVF---------LEMVPRFLCMPPLVDESEATTEVNG---------------------------- -----------------IRERRRSSFGLMQRAEEYVL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KQPRSEMMFDKQRERHGLT------- -----------------------------------------------------TANLYKSLAQAAPEIKQCVDACNFIAD SKRQQNTIGSEIE------------------------------------------------------------------- ----------------------------------------------------------SWVLIGKMIDKVCFWAAILLFI IGTVAIFLMGHFNRAPDFPFPGQNKK------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNE_a -------------------------------------------------------------------------------- ----------------------NE-------------------------------------------------ETELIKD LFK---DYNKK-------------------------------------IRPVVHPEDK---------------------- --VEVQIKLTLTNLISLNE------------------------------------------------------------- -----K--EETLTTNVWIE------------------------------------------------------------- ----------------------------------------------IQWIDYR-LSWNESE------------------- --YYG---INIIRVPCKTVWLPDIVLENN------IDGKFDVA-----YYANVLVSSNGGMYWLPPAIYRSTCA----IE IT-------YFPFDYQNCTLAFRSQTYSANE----VELILTIGEKNE-------------------TIEWVDIDPEAFT- -ENGEWAIVHRPARKVINTRYS-------------------PDDLE-YQEIMFNLVIQR--------------------- --------------------KPLFYIINVILPCSLISSLVVLAYFLPAQ-AGG-----------------QKLTVS---- ISVLLAQTVFLFLI----------------------AQKVPETSLSVPLIGKYLIFVMCVTTLIATNQIVVLNFSLR-SP STHT-MSQTIK----HVF---------LELVPRLLCMPPLVDEGEATAVVNG---------------------------- -----------------IRERRRSSFGLMQRAEEYVL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KQPRSEMMFDKQRERHGLTRSI---- ---------------------------------------------VDNIDVTSTANLYKSLAQAAPEIKQCVDACNFIAD SIRQQNTIGSEIE------------------------------------------------------------------- ----------------------------------------------------------NWVLIGKMIDKVCFWAAILLFI IGTVAIFFMGHFNRAPDFPFPGEDKKYVPS-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNE_a -----------------------------------------------------------------------------MAE SRFWIFFGVVAVLGTLTARVQCNE-------------------------------------------------ESELIRD LFK---GYNKN-------------------------------------IRPVVHPEDK---------------------- --LTIQIKLTLTNLISLNE------------------------------------------------------------- -----K--EETLTTNVWIE------------------------------------------------------------- ----------------------------------------------IQWVDYR-FVWNTSN------------------- --YHG---IDVIRVPCKTIWLPDIVLENN------IDGKFDVA-----YYANVLISYDGSMYWLPPAIYRSTCA----IE IT-------YFPFDYQNCTLAFRSQTYSANE----VDLILAVGDEME-------------------TIEWVDIDPQAFT- -ENGEWAIVHRPGRKMINPRYT-------------------PDDLE-YQEILFNLVIQR--------------------- --------------------KPLFYIINIILPCSLISSLVVLAYFLPAQ-AGG-----------------QKLTVS---- ISVLLAQTVFLFLI----------------------AQKIPETSLSVPLIGKYLIFVMSVTTLIATNQIVVLNFSLR-SP STHT-MSNTIK----HVF---------LEMVPRFLGMPPLVDDTEVTTVVNG---------------------------- -----------------VRERRRSSFGLLQRAEEYVL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KQPRSEMMFDKQRERHGLTRSI---- ---------------------------------------------VDDMDVSSTANLYKSLAQAAPEIKQCVDACNFIAE STRQQNSIGSEIE------------------------------------------------------------------- ----------------------------------------------------------SWVLIGKMIDKVCFWAAISLFI IGTVWIFLTGHFNRAPEFPFPGQSKKYVPS-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNE_a -------------------------------------------------------------------------------- ---MPVFSSPLLQYIMIEIVHCNE-------------------------------------------------ESQLIGD LFR---NYNKN-------------------------------------IRPVEHPEDK---------------------- --VQVMIKLTLTNLISLNE------------------------------------------------------------- -----K--EETLTTNVWIE------------------------------------------------------------- ----------------------------------------------IQWTDYR-LVWNTSQ------------------- --YYG---IKTIRVPYNTVWLPDIVLENN------IDGKFDVA-----YYANVLISNEGWMYWLPPAIYRSTCA----IE IT-------YFPFDYQNCTLAFRSQTYSAKE----VDLVLATGDEDV-------------------TIEWVDIDPEAFT- -ENGEWAIVHRPARKVINTRYS-------------------PDDLE-YQEIIFNLVIQR--------------------- --------------------KPLFYIINVILPCSLISSLVVLAYFLPAQ-AGG-----------------QKLTVS---- ISVLLAQTVFLFLI----------------------AQKTPETSLAVPLIGKYLIFVMCVTTLIATNQIVVLNFSLR-SP STHT-MSYSIK----HLC---------LEMVPRFLGMSPLVDDSEVTAEVNG---------------------------- -----------------IRERRRSSFGLMQRAEEYVL------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------KQPRSEMMFDKQRERHGLTRSI---- ---------------------------------------------VDNIDVSSTANLYKSLAQAAPEIKQCVDACNFIAE STKQQNDIGSVXE------------------------------------------------------------------- ----------------------------------------------------------SWVLIGKMIDKVCFWAAMLLFS -GTVGIFLTGHVNKAPEFPFPGEDKKYVP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Homo_sapiens_CHRNA5 -------------------------------------------------------------------------MAARGSG PRALR-LLLLVQLVAGRCGLAGAA---------------------------------GGAQRGLSEPSSIAKHEDSLLKD LF--QD-YERW-------------------------------------VRPVEHLNDK---------------------- --IKIKFGLAISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWIDVK-LRWNPDD------------------- --YGG---IKVIRVPSDSVWTPDIVLFD------NADGRFEG------TSTKTVIRYNGTVTWTPPANYKSSCT----ID VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDQD----------------------------VDKRDFF- -DNGEWEIVSATGSKGNRTDSC--------------------C---WYPYVTYSFVIKR--------------------- --------------------LPLFYTLFLIIPCIGLSFLTVLVFYLPSNEG-------------------EKICLC---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSS -THNAMAPLVRKIFLH-------------TLPKLLCMRSHVD-------------------------------------- ---------------------RYFTQKEETESGS---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------GPKSSRNTLEAALDSIRYITR HIMKEND------------------------------------------------------------------------- ------VRE----------------------------------------------VVEDWKFIAQVLDRMFLWTFLFVSI VGS-LGLFVPVIYKWANILIPVHIGNANK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Xenopus_tropicalis_CHRNA5 -------------------------------------------------------------------------------- -------MPWCAEYLLWLFLCLDI---------------------------------LHGACGISEPSYIAKSEDRLFKY LFQQQD-YQRW-------------------------------------VRPVEHLNDT---------------------- --VKVKFGLAITQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWVDVK-LRWDPNE------------------- --FAG---ITSIRVPSDSIWIPDIVLYD------NADGRFEG------SVTKAVVRYDGTINWTPPANYKSSCT----ID VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDYH----------------------------VDKRDFF- -DNGEWEIVNATGNKGNRTDGC--------------------C---FYPYITYSFIIKR--------------------- --------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNEG-------------------EKISLC---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLVFTMIFVTLSIVLTVFAINIHNRSSA -THNAMAPWVRKIFLH-------------KLPKLLCMRSHVD-------------------------------------- ---------------------RYFTRKDETGKVR---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------GPESSRNTLEAALDSIRYITR HVMKEHE------------------------------------------------------------------------- ------VQE----------------------------------------------VVEDWKFVAQVLDRMFLWTFLLVSV IGS-LFLFIPVIHKWANIIVPVHIGNMYGDKNT----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Danio_rerio_CHRNA5_a -------------------------------------------------------------------------------- -----MVTALSLVRALLPLVCSAV---------------------------------LCSAIGPPMLSSYAKTEDKLFKH LFS--N-YQKW-------------------------------------VRPIEDLNTT---------------------- --IQVKFGLAISQLVDVD-------------------------------------------------------------- -----EK-NQLMTTNVWMK------------------------------------------------------------- ----------------------------------------------QEWTDLK-LRWDPDH------------------- --YLG---ITSIRVPSDSIWIPDIVLYD------NADGNFEA------TVTKAVVRFDGTISWTPPANYKSACT----ID VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDILLEDVH----------------------------VDKRDYF- -DNGEWEIVKATGNRGLRRDGT--------------------F---FYPSITYSFIIRR--------------------- --------------------LPLFYTLFLIIPCIGLSFLTVLVFYLPSNGG-------------------EKISLC---- TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSS -THHSMAPWVRRIFLH-------------HLPRLLCMRSHVD-------------------------------------- ---------------------RYATSAGTRTGGLG--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------YGKSLSQD--------------- ----------------------------------------------------------TNQLDAEHNLQAALESIRYITR HVVKENE------------------------------------------------------------------------- ------VRE----------------------------------------------VVQDWKFVAQVLDRVFLWAFLLVSL LGS-ALLFIPVIYKWASIIVPSYAEITS---------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Takifugu_rubripes_CHRNA5_a -------------------------------------------------------------------------------- -------STEIRISMTVNLWVITV---------------------------------FLHLLEVPKLSSCAKAEDKLFKY LFG--N-YQKW-------------------------------------VRPVDHLNQT---------------------- --IRVKFGLAISQLVDVD-------------------------------------------------------------- -----EK-NQRMTTNVWMK------------------------------------------------------------- ----------------------------------------------QEWTDMK-LRWNPEE------------------- --YAG---ITIIRVPSDRIWRPDVVLYDK-----SSDGRFEG------TITKAVVKYDGTITWTAPANYKSACT----ID VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDFH----------------------------VDKRDYF- -DNGEWEIVKATGSRGLRMDGS--------------------T---SYPTITYFFIIRR--------------------- --------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNGG-------------------EKISLC---- TSVLVSLTVFLLVI----------------------EEIIPSSSKAIPLIGEYLVFTMIFVTLSIVITVFAINVHHRSSS -THNDMAPWVRRVFLH-------------HLPKLLCMRSHVD-------------------------------------- ---------------------RYATSGAARTRGL---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------GMAEGSEPEL--------------- ----------------------------------------------------------TPLFYTRQNLKAALDSIRYITM HVVKENE------------------------------------------------------------------------- ------VREYPHARGLSQQVSKSLNSFQAQTCSQTCRFLPSIDMKKKKAKEIHFKVVQDWKFVAQVLDRMFLWAFLLVSI LGS-ALLFIPVIYKWASIIV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Tetraodon_nigroviridis_CHRNA5_a -------------------------------------------------------------------------------- ---------------------------------------------------------------VPKLSSYAKAEDKLLKY LFG--N-YQKW-------------------------------------VRPVDHLNQT---------------------- --IRVKFGLAISQLVDVD-------------------------------------------------------------- -----EK-NQRMTTNVWMK------------------------------------------------------------- ----------------------------------------------QEWTDMK-LRWSPEE------------------- --YVG---ITIIRVPSDRIWRPDVVLYD------NSDGRFEG------TVTKAVVKHDGTITWTAPANYKSACT----ID VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDFH----------------------------VDKRDYF- -DNGEWEIVKATGSRGLRTDGS--------------------A---SYPTITYFFIIR---------------------- --------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNGG-------------------EKISLC---- TSVLVSLTVFLLVI----------------------EEIIPSSSKAIPLIGEYLVFTMIFVTLSIVITVFAINVHHRSSS -THNDMAPWVRRVFLH-------------RLPKLLCMR-HVD-------------------------------------- ---------------------RYATSGASRARAL---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------GMAEST-PEL--------------- ----------------------------------------------------------TPLLYSRQSLKAALDSIRYITM HVVKENE------------------------------------------------------------------------- ------VRE----------------------------------------------VVQDWKFVAQVLDRMFLWAFLLVSI LGS-AILFIPVIYKWASIIVPNHETMVFGN-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Gasterosteus_aculeatus_CHRNA5_a -------------------------------------------------------------------------------- ---------------------------------------------------------MCHSLRVPKLSSFAKAEDKLFKY LFG--N-YQKW-------------------------------------VRPVEYLNQT---------------------- --ISVKFGLAISQLVDVD-------------------------------------------------------------- -----EK-NQQMTTNVWMK------------------------------------------------------------- ----------------------------------------------QEWIDRK-LRWNPDD------------------- --YLG---ITTIRVPSNRIWLPDVVLYD------NSDGRFEA------TVTKAVVKYNGTISWTPPANYKSACT----ID VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDITLEEFH----------------------------VDKKDYF- -DNGEWEIVKATGSRGLRTDSS--------------------S---TYPTITYFFIIRR--------------------- --------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNGG-------------------EKISLC---- TSVLVSLTVFLLVI----------------------EEIIPSSSKAIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSS -THHNMAPWVRRIFLH-------------RLPKLLCMRSHAD-------------------------------------- ---------------------RYATAGVARTGGAERE------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------GKMKDSAPEL--------------- ----------------------------------------------------------TSLLYTKHNLQAALESIRYITM HVVKENE------------------------------------------------------------------------- ------VRE----------------------------------------------VVQDWKFVAQVLDRMFLWAFLLVSI LGS-ALLFIPVIYKWANIIVPKHFGS------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------- >Oryzias_latipes_CHRNA5_a -------------------------------------------------------------------------------- ---------------------------------------------------------------VPKLSSYAKAEDTLFKH LFG--T-YQKW-------------------------------------VRPIEYLNQT---------------------- --IPVKFGLAISQLVDVD-------------------------------------------------------------- -----EK-KQLMTTNVWLK------------------------------------------------------------- ----------------------------------------------QEWIDMK-LRWKPED------------------- --YLG---ITTIRVPSDRIWLPDVVLYD------NSDGRFEG------TVTKAVVKYDGTISWNPPANFKSACT----ID VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDFH----------------------------VDKKDYF- -DNGEWEIVKATGSRGLRTDGS--------------------T---SYPTITYFFIIRR--------------------- --------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNGN-------------------EKISLC---- TSVLVSLTVFLLVI----------------------EEIIPSSSKAIPLIGEYLVFTMIFVTLSIIITVFAINIHYRSSS -THHDMAPWVRRIFLH-------------RLPKLLCMRSHVD-------------------------------------- ---------------------RYATAGLAGKGKVTVQ------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------EKTKDSTPDL--------------- ----------------------------------------------------------THILHTRHNLQTALESIRYITM HVVKENQ------------------------------------------------------------------------- ------VRE----------------------------------------------VVQDWKYVAQVLDRMFLWAFFLVSV LGS-ALLFVPVIYKWASIIVPDYAGS------------------------------------------------------ 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