>Homo Sapiens_WDR62 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAVGS--GGYARNDAGEKLPSVMAGVPARRGQ----SSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGIT--AQNSSGLTCD--------------------------PGTGHVAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VILDPKENK-QQHIFNTARKSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVEEKNQ---------------VAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCR-----VIALSFSEDSSYFVTVG--NRHVRFWFLEVSTETK--VTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKR-----------------VLEKWINLKVS-------LSSCLCVSQELIFCG-------CTDGIVRIFQAHSLHYLANLP-------KPHYLGVDVAQGLEP--SFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVK---DINRVGKVWSELFHSSYVWNVEVYPEFED-------------QRACLPSGSFLTCSSDNTIRFWNLDS-------------------SPDSHWQKN--------------------------------------------IFSNTL----------------------------------------LKVVYVEND---IQHLQDMSHFPDRG---------SENGTPM------DVKAGVRVMQVSPDGQHLASGDRSG-NLRIHELHFMDELVKVEAHDAEVLCLEYS--------KPE-TGLTLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAIKFAG-NRDIQMISCGADKSIYFRSAQ---QGS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTVNGKQKKCYKGSQGDEGS-LLKVHVD-----------PSGTFLAT---SCSDKSISVIDFYSGECIAKMFGHSE-IITS--------MKFTY-------DCHHLITVS-----------GDS--CVFIWHLGPEITNCMKQHLLEIDHRQQQ-------------------QHTNDKKRS------GHP--RQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDS--------------------------------------------------------------------------------LDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHA---------KRSYQPHGRWAERA------GQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSE----------------------SESPQEAGRGHPSFLPQQKESS-EASELILYSLEAEVTVTG-TDSQYCRKEVEAGPGDQQGDSYLR-----------------VSSDSP--------KDQSPPEDSGESE-------ADLECSFAAIHSPAPPPDPAPRFAT-SLPHFPGCAGPTEDELS-LPEGPSVPSSSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLTESPCRELFPAALGDVEASEAEDH-----FFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQP-----RAGTGYASPDRTHVLAAGKAEE-----TL-----EAWRPPPPCLTSLASCVPASSVL------------------------------------------------------PTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISLGDSEGPIVATLAQP---------------------------------------------------------------------------------------------------LRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGN------------------------------------------------------------------------------------------------------------------------------HEARANLRLTLSSACDGLLQP---------------------------------------------------PVDTQPGVT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPAVSFPAPSPVEESALRLHGSAFRPSLP-----------------------------------------------------APESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPP-----SPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEA-ECLVG-------------------------------TSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH---------- >Macaca mulatta_WDR62 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAVGS--GGCARNDAGEKLPSVMAGVPARRGQ----SSPPPAPPLCLRRRTRLSTASEETVQNRVSLEKVLGIT--AQNSSGLTCD--------------------------PGTGHVAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VILDPKENK-QQHIFNTARKSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVEEKNQ---------------VAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCR-----VIALSFSEDSSYFVTVG--NRHVRFWFLEVSTETK--VTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKR-----------------VLEKWINLKVS-------LSSCLCVSQELIFCG-------CTDGIVRIFQAHSLHYLANLP-------KPHYLGVDVAQGLEP--SFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVK---DINRVGKVWSELFHSSYVWNVEVYPEFED-------------QRACLPSGSFLTCSSDNTIRFWNLDS-------------------SPDSHWQKN--------------------------------------------IFSNTL----------------------------------------LKVVYVEND---IQHLQDMSHFPDRG---------SENGTPM------DVKAGVRVMQVSPDGQHLASGDRSG-NLRIHELHFMDELVKVEAHDAEVLCLEYS--------KPE-TGLTLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAIKFAG-NRDIQMISCGADKSIYFRSAQ---QGS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTVNGKQKKCYKGSQGDEGS-LLKVHVD-----------PSGTFLAT---SCSDKSISVIDFYSGECIAKMFGHSE-IITS--------MKFTY-------DCHHLITVS-----------GDS--CVFIWHLGPEITNCMKQHLLEIDHQEQQ-------------------QHTKDRKQN------SHP--RQDTYVSTPSEIRSLSPGEQTEDDLEEECEPEEMLKTPSKDS--------------------------------------------------------------------------------LDPDPRCLLTNGKLPLWAKRLLGDDDVADGSAFHA---------KRSYQPHGRWAERA------GQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSE----------------------SESPQEAGRGHPSFLPQQRESS-EASELILYSLEAEVTVTG-TDSQYCGKEAEARPGDQQGDSYLR-----------------VSSNSP--------KDQSPPEDSGESE-------ADLECSFAAVHSPAPPPDPAPRFAT-LLPHFPGCAGPTEDELS-LPEGPSVPSSSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLTESPCRELFPAALGDVEASEAEEY-----FFNPRLSISTQFLSSLQKASRFTHTLPPRATQHLVKSPEVKPMDQVGSQP-----RADTGYASPDGTHVLAAGKAEE-----TL-----EAWRPPPPCLTSLASCVPASSVL------------------------------------------------------PTDRKLPTPTSVSTPGLAQAVHTPSTCSYMEATASSHARISRS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISVGDSEGPIVATLAQP---------------------------------------------------------------------------------------------------LRRPSSVGELASLGQELQAITAAATPNLGSEGQEPALHSWGN------------------------------------------------------------------------------------------------------------------------------HEARANLRLTLSSVCNGLLLP---------------------------------------------------PVDAQPGVT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPAVSFPAPSPVDESTLRLHGSAFRPGLP-----------------------------------------------------APESPGLPAHPSSPQLPEAGPGIPGGTASLLEPTSGALGLFQGSPARWSEPWVPAEALPP-----SPLELNRVGNILHRLQTTFQEALDLYRVLISSGQVDTRQQQARTELVSTFLWIHSQLEA-ECLVG-------------------------------TSVAPAQTLPSPGPPSPPTLCPLASPDLQALLEHYSELLVQAVRRKARGH---------- >Saimiri boliviensis boliviensis_WDR62 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAVGS--GGYARNDAGEKLTSVMAGVPARRGQ----SSPPPAPPLCLRRRTRFSTAPEETVQNRVSLEKVLGIT--AQNSSGLTCD--------------------------PGTGHVAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VILDPKENK-QQHIFNTARKSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVEEKNQ---------------VAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCR-----VIALSFSEDSSYFVTVG--NRHVRFWFLEVSTETK--VTGTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKR-----------------VLEKWINLKVS-------LSSCLCVSQELIFCG-------CTDGIVRIFQAHSLHYLANLP-------KPHYLGVDVAQGLEP--SFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDIK---DINRVGKVWSELFHSSYVWNVEVYPEFED-------------QRACLPSGSFLTCSSDNTIRFWNLDS-------------------SPDSHWQKN--------------------------------------------IFSNTL----------------------------------------LKVVYVEND---IQHLQDMSHFPDRG---------SENGTPM------DVKAGVRVMQVSPDGQHLASGDRSG-NLRIHELHFMDELVKVEAHDAEVLCLEYS--------KPE-TGMTLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAIKFAG-NRDIQMISCGADKSIYFRSAQ---RGS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTVNGKQKKCYKGSQGDEGS-LLKVHVD-----------PSGTFLAT---SCSDKSISVIDFYSGECIAKMFGHSE-IITS--------MKFTY-------DCHHLITVS-----------GDS--CVFIWHLGPEITNCMKQHLLEIDRREQQ-------------------QHTKDRKWS------GHP--RQDTYVSTPSEIRSLSPGEQTEDDLEEECEPEEMLKTPSKDS--------------------------------------------------------------------------------MNPDPRCLLTNGKLPLWAKRLLGDDDVPDGSAFHA---------KRSYQPHGRWAERA------GQEPLKTILDAQDLDCYFTPMKPENLENSVLDSLEPQSLAGLLSE----------------------SESPQEAGHGHSSFLPQQRESSNEASELILYSLEAEVTVTG-TDSQYCGKEAEVGPGDQQGDSYLR-----------------VSSISP--------KDQSPPEDSGESE-------ADLECSFEAVHSPVPPPHPTPQFVT-LLPHFPGCTGPTEDELS-LPEGPSIPSSSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLTESPCRELFPTALGDTEASETEDY-----YFNPRLSISTQFLSSLQKASRFTHTFPSRATQHLVKSPEVKPTDRGGSQP-----RAGTGYTSQDGTHVLTAGKAQE-----TL-----EAWRPPPPCLTGLVPCVPASSVL------------------------------------------------------PTDGKLPTPTSALTLGPAQGVHAPSTCSYMEAPANSRARISRS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISLGDSKGPIVAELARP---------------------------------------------------------------------------------------------------LCRPSSVGDLASLGQELQTITTTVTPNLDSEGQEPALHSWGN------------------------------------------------------------------------------------------------------------------------------HEARANLRLTLSSVCDELLLP---------------------------------------------------TVDAQPGVT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPEASFSAPNPIDGSALRLHGSAFLPSLP-----------------------------------------------------VSESPGIPAHPSSPQLPEAGPGVPGATASLLEPTSGALGLIEGSPACWSEPWVPAEALSP-----SPLELSRVGNILHRLQTAFQEALDLYRVLVSSGQVDTRQQQARNELVSTFLWIHSQLEA-NCLVG-------------------------------TSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH---------- >Mus musculus_WDR62 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMAALAA--GGYTRSDTIEKLSSVMAGVPARRNQ----SSPPPAPPLCLRRRTRLAAAPEDTVQNRVTLEKVLGIT--AQNSSGLTCD--------------------------PGTGHVAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VVLNPKENK-QQHIFNTTRKSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVEEKTQ---------------VAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCR-----VIALSFSEDSSYFVTVG--NRHVRFWFLEASTEAK--VTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGNTFCVSYSGLLCQFNEKR-----------------VLDKWINLKVS-------LSSCLCVSDELIFCG-------CTDGIVRIFQAHSLLYLTNLP-------KPHYLGVDVAHGLDS--SFLFHRKAEAVYPDTVALTFDPVHQWLSCVYKDHSIYIWDVK---DIDEVSKIWSELFHSSFVWNVEVYPEFED-------------QRACLPSGTFLTCSSDNTIRFWNLDS-------------------ASDTRWQKN--------------------------------------------IFSDSL----------------------------------------LKVVYVEND---IQHLQDLSHFPDRG---------SENGTPM------DMKAGVRVMQVSPDGQHLASGDRSG-NLRIHELHFMDELIKVEAHDAEVLCLEYS--------KPE-TGVTLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAIKFAG-TRDVQMISCGADKSIYFRSAQ---QAS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTVSGKQKKCYKGSQGDEGS-LLKVHVD-----------PSGTFLAT---SCSDKSISLIDFYSGECVAKMFGHSE-IVTG--------MKFTY-------DCRHLITVS-----------GDS--CVFIWHLGPEITTCMKQHLLEINHQEQQ-------------------QQPKDQKWS------GPP--SQETYASTPSEIRSLSPGEQTEDEMEEECEPEELLKTPSKDS--------------------------------------------------------------------------------LDPDPRCLLTNGKLPLWAKRLLGDDDVADSSAFHA---------KRSYQPHGRWAERA------EQEPLKTILDAWSLDSYFTPMKPENLQDSVLDSVEPQNLAGLLSECSLGNGHTSPGEGLVSYLLHPELGSPKEDNRGHPSYLPLQREAT-EASELILCSPEAEVSLTG-MHREYYEEETEAGPEDQQGDTYLR-----------------VSSVSS--------KDQSPPEDSGESE-------AELECSFAAAHSSAPQTDPGPHLT--MTAGKPEYPS--TEELS-QPELPGLGNGSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLTDAPTEELFHGSLGDIKISETEDY-----FFNPRLSISTQFLSRLQKTSR----CPPRLPLHLMKSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEE-----TQ-----EALSL-------------------------------------------------------------------------LDRKPPTPTSVLTTGREQSISAPSSCSYLESTTSSHAKTTRS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISLGDSEGPVTAELPQS---------------------------------------------------------------------------------------------------LHKP------LSPGQELQAIPTTVALTSSIKDHEPAPLSWGN------------------------------------------------------------------------------------------------------------------------------HEARASLKLTLSSVCEQLLSPPP-------------------------------------QEPPITHVWSQEPVDVPPSMA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTVASFCAPSPVDMSTLGLHSSMFLPKTS-----------------------------------------------------ASGPLTPPAH---LQLLETRSRVPGSTAALLEPTPDASGVIADSPGHWD-----TEVPTP-------ELLGSVESVLHRLQTAFQEALDLYRMLVSSSQLGPEQQQAQTELASTFHWILNQLEASNCMAA-------------------------------ANLAPPQTLPSPDPLSLPTLCPLASPNLQALLEHYSELLVQAVRRKARGD---------- >Rattus norvegicus_WDR62 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMAALAA--GGYARSDTIEKLSSVMAGVPARRNQ----SSPPPAPPLCLRRRTRLAAAPEDTVQNRVTLEKVLGIT--AQNSSGLTCD--------------------------PGTGHVAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VVLNPKENK-QQHIFNTTRKSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVEEKTQ---------------VAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCR-----VIALSFSEDSSYFVTVG--NRHVRFWFLEASTEAK--VTSTMPLVGRSGILGELHNNIFCGVACGRGRMAGNTFCVSYSGLLCQFNEKR-----------------VLDKWINLKVS-------LSSCLCVSDELIFCG-------CTDGIVRIFQAHSLLYLTNLP-------KPHYLGIDVAQGLDS--SFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSVYIWDVK---DINEVSKIWSELFHSSFVWNVEVYPEFED-------------QRACLPSGTFLTCSSDNTIRFWNMDS-------------------GSDTQWRKN--------------------------------------------IFSDSL----------------------------------------LKVVYVEND---IQHLQDMSHFPDRG---------SENGTPM------DMKAGVRVMQVSPDGQHLASGDRSG-NLRIHELHFMDELIKVEAHDAEVLCLEYS--------KPE-TGVTLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAIKFAG-TRDVQMISCGADKSIYFRSAQ---QTS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTVSGKQKKCYKGSQGDEGS-LLKVHVD-----------PSGTFLAT---SCSDKSISVIDFYSGECVAKMFGHSE-IVTG--------MKFTY-------DCRHLITVS-----------GDS--CVFIWHLGPEITTCMKQHLMEINHQEQQ-------------------HLPKDQKWS------GPP--SQETSASTPSEIRSLSPGEQTEDEMEEECEPEETLKTPSKES--------------------------------------------------------------------------------LDPDPRCLLTNGKLPLWAKRLLGDDDVTDSSAFHA---------KRSYQPHGRWAERA------EQEPLKTILDAWALDSYFTPMKPGNLEDSVLDSVEPQNLAGLLSECSPENGHTAPGEGLVSYLCHSESGSPKEDSRGHPSYLPLQREGT-ETRELILCSPEVEVTVTG-MHREYYEEA-EAGPEDQQGDSYLR-----------------VSSVSS--------KDQSPPEDSGESE-------AELECSFAAAHVSAPRTDPGPHLT--MTG-KPEHSS--TDELA-QPGVPGLGNGSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLTDAPAEELFPGSLGDIKISETDDY-----FFNPRLSISTQFLSRLQKTSR----FPPRLPLHLMKSPEVQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQMAEE-----TP-----EASCLPTPPITGLASCVPPSSVI------------------------------------------------------PTDRKPPTPTSGLTTGREQSIPAPSPCSYLESTTSSHAKMTRS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSLGDSEGPVTGELPRP---------------------------------------------------------------------------------------------------LHKP------VSPGQEPQAVPTTVALTSSVKGHEPALPAWGN------------------------------------------------------------------------------------------------------------------------------HEARASLRLTLSSVCEQLLSPPQ-------------------------------------LEPPTTPVWSQEAVDVPPSMA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTVASFSAPSPEDMSTLGLHSSVFLPKTS-----------------------------------------------------ASGPLTPPAHPNSLQLLETRSRMPGSTPALLEPTPDASSGSPDSPGHCGEPGRRAEVPPP-----GPLELDSVESVLYRLQTAFQEALDLYRMLASSNQLGAEQQQAQTELASAFHWIHHQLEASNCVGA-------------------------------ASVAPPLTLPSPGPPSPPTLCPLASPNLQALLEHYSELLVQAVRRKVRGD---------- >Equus caballus_WDR62 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAIGP--GGFARNDAVEKLPSVMAGVSARRSQ----SSPPPAPPVCLRRRTRPLAAPEDTMQNRVSLEKVLGIT--AQNSNGLTCD--------------------------PGTGHVAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VILNPKENK-QQHIFNTARKSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVDEKSQ---------------VAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKGILVASNKVSCR-----VIALSFSEDSSYFVTVG--NRHVRFWFLEVSTEAK--VTGTVPLVGRSGILGELHNNVFCGVACGRGRMAGNAFCVSYSGLLCQFNEKR-----------------VLEKWINLKVS-------LSSCLCVSQELIFCG-------CTDGIVRIFQAHSLHYLANLP-------KPHYLGVDVAQGLEP--SFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVK---DINKVGKMWSELFHSSYVWNVEVYPEFED-------------QRACLPSGSFLTCSSDNTIRFWNMDS-------------------SPDSHWQKN--------------------------------------------IFSNTL----------------------------------------LKVVYVEND---IQHLQDMSHFPDRG---------SENGTPL------DVKAGVRVMQVSPDGQHLASGDRSG-NLR--QLHFMDELVKVEAHDAEVLCLEYS--------KPE-TGLTLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAIKFAG-TRDIQMISCGADKSIYFRSAQ---QAS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTVNGKQKKCYKGSQGDEGS-LLKVHVD-----------PSGTFLAT---SCSDKSISVIDFYSGECIAKMFGHSE-IVTS--------MKFTY-------DCRHLITVS-----------GDS--CVFIWHLGPELTNCMKQHLLEIDRREQQR------------------QETKDGMWS------SQP--RQETYVSMPSETCSLSPGEQTEDELEDECEPEELLKTPSKES--------------------------------------------------------------------------------LDPDPQCLLTNGKLPLWAKRLVNDDDVVDGSAFHA---------RRSYQPHGRWAERA------DQEPLKTILDARDLDCYFTPMKPESLEDSLLDTVEPQSPAGLLSE----------------------PESPRDDGCGHPSFLPLQRESS-EASELIIYSPEAEVTVTG-TDSEDCAKEGMREPGDQQGDCYLQ-----------------VPSIGL--------KHQSPPEDSGESE-------ANLECSFATIHSSPPQPDPDPRFDPLAFPSRPGCPG-TAEELS-QPEVPSISNGSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLTDAPPEELFHGSLRDVQASEAED------YFNPRLSISAQFLSRLQNTSRFSHTCPPQLPLHLGKPPEVKRSDFRGSQPRAEPPRVDAGCTSPGRTSVLSVGMAEEP--LEPL-----EAWCPLTPCLTGLPPCVPSSSVL------------------------------------------------------PTDGKPLTPTALPTPGLAQEVCTPSTRSYLQTTASSRAKMSRS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISVEDRESPVLAELPRP---------------------------------------------------------------------------------------------------LRRPSSMGELASLGQDLQAVS-TAAPSSDSEAQEPALPSWGN------------------------------------------------------------------------------------------------------------------------------HEARASLKLTLSNICDGLLLPPPL------------------------------------LEPPTTCVWSQEPVATQPDVM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AATASFLAHSPMDGSTLRLHNSAFLPRLP-----------------------------------------------------APEPLNTPAHPNKPPLPEASPGAPGSITSLLEPTPGEYHPQDKGFDHCGSPRRWGEPGMP-----APLELSSVETIVHRLQTTFQEALDLYHLVVSSDQVSAEQRQARTELASTFHWIHCQLEANDWLLG-------------------------------TDVAPDQALPSPGPPSPPTLCPLASPDLHALLEHYSELLVQAVRRKARGD---------- >Loxdonta africana_WDR62 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAALGP--GGYARNDAVEKLSSVTAGVPARRGQ----PSPPPAPPLCLRRRTRLTAAPEDTVQSRVSLEKVLGIT--AQNSSGLTCD--------------------------PSTGHVAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VILDPKENK-QQHIFNTARKSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVDEKSQ---------------VAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCR-----VIALSFSEDSSYFVTVG--NRHVRFWFLEVSTEAK--VTGTVPLVGRSGILGELHNNVFCGVACGRGRMAGNTFCVSYSGLLCQFNEKR-----------------VLEKWINLKVS-------LSSCLCVSQELIFCG-------CTDGVVRIFQAHSLHYLTNLP-------KPHYLGVDVAQGLEP--SFLFRRKAEAIYPDTVALTFDPTHQWLSCVYKDHSIYIWDVQ---DINKVSKIWSELFHSSYVWNVEVYPEFED-------------QRACLPSGSFLTCSSDNTIRFWNTDS-------------------SPDSHWQKN--------------------------------------------IFSNTL----------------------------------------LKVVYVEND---TQHLQDTSHFPDRG---------SENGTPM------DVKAGVRVMQVSPDGQHLASGDRSG-NLRIHELHFMDELLKVEAHDAEVLCLEYS--------KPE-TGLTLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAIKFAG-NRDIQMISCGADKSIYFRSAQ---RAS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTVNGKQKKCYKGSQGDEGS-LLKVHVD-----------PSGTFLAT---SCSDKSISVMDFYSGECVAKMFGHSE-IVTG--------MKFTY-------DCRHLITVS-----------GDS--CVFIWHLGPEITSCMKQHLLEIDHREGWE------------------LEQPAQVWWPP----DQPPSEQEACASMPSEARSISPGEQTEDELEEECEPEEMLKTPSKES--------------------------------------------------------------------------------LDPDPRCLLTNGKLPLWAKRLLGDDDVADGSAFHA---------KRSYQPHGRWAERA------DQEPLKTILDARDLDCYFTPMKPESLEDSVLDTVEPQSLVDLLSEGSDGDPVLRPGPGPLEVLLHMFSECPQENSCGHPSFLPLQRGSE--ASELVTYSLEAAVTVSG-TDSKYRVGEEDGGRADQQDDSYLR-----------------ISSTGS--------KAQSPPEDSGESE-------ADLECSFATIHSSPPRPDPDPRFDA-TVSHTPGCPGPAEEEQA-LPEGPGLTSSSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLADTQPEELFHRSLRDVTASEAEDF-----FLNPRLSISAQFLSRLRKKPRFTHTFPPQLPLHLMKSSEVNPMDQGGSQPR-AELRAGTGYASPDQTNVLSGGEADEL--LETV-----EAWHPLN-------------------------------------------------------------------------RRPPLPASIPTPGLAQGVRVPSTCSYMEATASSRAKMSHS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSLRDRVGPVPAELARP---------------------------------------------------------------------------------------------------LCRPSSMGELASLGQELQAVTTTVAPSSGSEGREPALASRGN------------------------------------------------------------------------------------------------------------------------------HEARANLRLTLSSICDSFLLPPSP------------------------------------LEAPTTRAWSQEPVATQPCAT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTAARLLAPSPVNTSALRLPDPSFLPRLP-----------------------------------------------------APQPLNPSTHPGSSQLPETKPGISGSTAFLLEPTADAPSLVQSNPGHWEEPGLPAGVLPP-----APLELSGVETIVHRLQTAFQEALDLYLVLVSSGQVSAEQQQTRTELASTFLWIHSQLEA-HWLGG-------------------------------TEMAPAQALPSPGPPSPPTLCPLASPDLRALLEHYSELLVQAVRRKVEGD---------- >Orcinus orca_WDR62 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAALGP--GGYARNDAVEKLPSIMAGVPARRAQ----SSPPPVLPLCLRRRTRLSAAPEDTVQNRVSLEKVLGIT--AQNSNGLTCD--------------------------PSTGHVAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VILNPKENK-QQHIFNTARKSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVEEKSQ---------------VAEMLGHKYGVACVAFSPSMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCR-----VIALSFSEDSSYFVTVG--NRHVRFWFLEVSTEAK--VTSTVPLVGRSGILGELHNNVFCGVACGRGQMTGSTFCVSYSGLLCQFNEKR-----------------VLEKWINLKVS-------LSSCLCVSQELIFCG-------CTDGIVRIFQAHSLQYLANLP-------KPHYLGVDVAQGLEP--SFLFSRKAEAIYPDTVALIFDPIHQWLSCVYKDHSIYIWDVK---DINKVGKVWSELFHSSYVWNVEVYPEFED-------------QRACLPSGSFLTCSSDNTIRFWNMDG-------------------SPDSHWQKN--------------------------------------------IFSNTL----------------------------------------LKVVYVEND---IQHLQNMSHFPDRG---------SENGMPV------DMKAGVRVMQVSPDGQHLASGDRSG-NLRIHELHFMDELVKVEAHDAEVLCLEYS--------KPE-TGLSLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAIKFAG-HKDIQMISCGADKSIYFRSAQ---QGS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTMNGKQKKCYKGSQGDEGS-LLKVHVD-----------PSGTFLAT---SCSDKSISVIDFYSGECVAKMFGHSE-IVTG--------MKFTY-------DCRHLITVS-----------GDS--CVFIWHLGPEITSCMKQHLLEIDHREQQQ------------------ENTKGRNWS------SHP--RQETYASMPNEICSLSPGEQTEDKLEEECEPEELLKTPSKES--------------------------------------------------------------------------------LDPDPRCLLTNGKLPLWAKRLLGDDDVADSSAFHA---------KRSYQPHGRWAERA------DQEPLKTILDARDLDCYFTPMKPESLEDSVLDTVEPQRLAGLLSE----------------------SESPQDNGCGPPSLPPLQRESS-EASELIIYPLETEVTVTG-TDSKYCAEEVERAPGDQQGDSYLR-----------------APSIDS--------KDQRPPEDSGESE-------ADLECSFTTIHSSPPQPDPDPQFD--VTPPTPGCPG-TTEELS-QPEVPSISNGSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLTDAHPEEPFHGSLRDLKASEAEDN-----FFNPRLSISGQFLSRLQKTSRFTHTFPSRLPLHLVKSPEVKLMDLRGSPPRAEPLRAGTGYTCPGRTNVISGGKAEEP--LETL-----EAWSPLTPCLTGLAPCILPSSVL------------------------------------------------------PTDKKPPTPTALPTPGLAQGFHTPAARSCMEATASSCARIPHS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISIEDSEGPVLAELARP---------------------------------------------------------------------------------------------------LCRSSSLGELASLGQELQVITTTVTPSSDSEGQEAALPSRGN------------------------------------------------------------------------------------------------------------------------------HEARASLKLTLPSICDRLVLPPPQ------------------------------------LEPPTTCVWSQEPVAIQPNVM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTTASFLAPSPVDGSAPRLHNATFLPRFL-----------------------------------------------------ATEALNTPSHPNSPPLPEARPGVPGSITSLLEPTPDALSPVQGCPGHCGEPRGPARVLPP-----DPLELSNVGTVVHRLQTTFQEALDLYHLMVSSDEVGAEQQQARTELASTFLWIHSQLEANDWLVG-------------------------------TDVAPAQALPNPGPPSPPTLCPLASPDLRALLEHYSELLVQAVRRKARGD---------- >Sarcophilus hairisii_WDR62 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVTLEKVLGIT--AQNSSGLTCD--------------------------PNTGHIAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VILDPKKSK-QQHIFNTARKALSALSFSPDGRYIVTGE---NGHRPAVRIWDVEEKSQ---------------VAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVVNVWDWKKDSVVASNKVSCK-----VIAISFSEDSSYFVTVG--HRHVKFWFLEMSKEVK--VTGTVPLVGRSGILGELHNNVFCGVACGRGRMAGNTFCVSYSGLLCQFNEKR-----------------VLEKWINLKVS-------LSSCLCVSEDLIFCG-------CTDGTVRIFQAHDMHYVTNLP-------KPHYLGVDVAQGLDP--SFLFSRKAQSVYPDTVALAFDPHHHWLSCVYKDHSIYVWDIL---DLTKVGKVWSDLFHSSYVWNVEVYPEFED-------------QRACLPSGSFLTCSSDNTIRFWNMES-------------------SPTSGRPKN--------------------------------------------VFSNNL----------------------------------------LKVVYVEND---IQHLQDISHFPDRG---------NENGTPV------DMKSGVRVMQVSPDGQHLASGDRSG-NLRIHELRFMDELIKVEAHDAEVLCLEYS--------KPE-TGVTLLASASRDRLIHVLNVD--KNYNLEQTLDDHSSSITAIKFAG-NRDIQMISCGADKSIYFRSAQ---KVS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTVNGKQKKCYKGSQGDDGS-LLKVHVD-----------PSGTFLAT---SCSDKSISVIDFYSGECIAKMFGHSE-IVTG--------MKFTY-------DCRHLITVS-----------GDS--CVFIWQLGPEITSCMKQHLMEIDHIEQQ-------------------KKLKERKWT------SQL--RRETYMSVPSGTCSLSPGEQTEDELEEECEPEELLKTPTKDS--------------------------------------------------------------------------------FETDPRCLLTNGKLPLWAKRLLGDEDV-DGATFHA---------KRSYQPHGRWAERA------DREPIKTILDARDLNYYFSPVNPDVLEDSGLEKVEPQNLAQLLNETE-----------------GQEDPSQTEGGFQCPDFLQLDLESS-KESDIIIYTLEPEALPEKRLQSEYHMKEVDIPPS-QRGNGYLR-----------------VGSVLKGDLDSRVRELQPEGGDSLESEAETEVEPADLEGSFKAIHSSPPQPKAE-KSPLELMPLVPDAESTLEVELI-GPEGPVPPSSSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLTDAHPE----GSLKDMEAPEVDTESEKHFFLNPRLSISAQFLSRFQKSPRFAHTFPPTLPLQLVKPLEAVALGRDGPE-------AQRSYEAADASDGLLGGKAAKSTETPAP-----ASWCPLISGVTGMGSGPPSEALMGPSLE-------------------------------------------------EERARKSKQSPPLPCTLARGGREPRARSYLESTTSSRAKMSRS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSLGENLTPTLTEPPRPPN------------------------------------------------------------------------------------------------GLRRPLSMGELSMLGQDGQPSPAREPSAPE---RGPDLPLWGN------------------------------------------------------------------------------------------------------------------------------HEARASLRLDLPNVCDPLRMPP-----------------------------------------------RSPPPAPAPAPR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPEMKAMGLYEPGFLHRLS-----------------------------------------------------GAQPPVQALPEGPAAIESVGPRGIASETPLLEPPSGECDHPKGSP--LPPPAQRPGLGPS-----HIATMRNVESVTQKLQRSFQEALDLYKMVVSSPQMSGEQQQIRAELSSTFLWIQGQLEAMTWLG---------------------------------VSPSPATSPAPGLPS-PLLWSLPSSEVRALLEHYSELLVQAVRRKAGGR---------- >Monodelphis domestica_WDR62 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAALEPGVGGYGRSEAGTRGEKEKQPGPVSSRRTLVSPPPPPPPPLCLKRRLKLLPGPEETVQSRVTLEKVLGIT--AQNSSGLTCD--------------------------PNTGYIAYLAGCVV--------------------------------------------------------------------------------------------------------------------------------------VVLDPKKSK-QQHIFNTARKALSALSFSPDGRYIVTGE---NGHRPAVRIWDVEEKSQ---------------VAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVVNVWDWKKDSVVASNKVSCK-----VIAISFSEDSSYFVTVG--HRHVKFWFLEVSKEVK--VTGTVPLVGRSGILGELHNNVFCGVACGRGRMAGNTFCVSYSGLLCQFNEKR-----------------VLEKWINLKVS-------LSSCLCVSEDLIFCG-------CTDGTVRIFQTHDMHYVTNLP-------KPHYLGVDVAQGLDP--SFLFCRKAQAVYPDTVALAFDPCHYWLSCVYKDHSIYVWDIR---DLSKVGKVWSDLFHSSYVWNVEVYPEFED-------------QRACLPSGSFLTCSSDNTIRFWNMEN-------------------SPTSGRPKN--------------------------------------------VFSNNL----------------------------------------LKVVYVEND---IQHLQDISHFPDRG---------NENGTPV------DMKSGVRVMQVSPDGQHLASGDRSG-NLRIHELRFMDELIKVEAHDAEVLCLEYS--------KPE-TGMTLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAIKFAG-NRDIQMISCGADKSIYFRSAQ---KVS-DGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYNTVNGKQKKCYKGSQGDDGS-LLKVHVD-----------PSGTFLAT---SCSDKSISVIDFYSGECIAKMFGHSE-IVTG--------MKFTY-------DCRHLITVS-----------GDS--CVFIWQLGPEITNCMKQHLLEIDHIEQQ-------------------KKMKDGKWT------SQL--RRETYVSMPSGTHSLSPGEQTEDELEEECEQEELLKTPTKDS--------------------------------------------------------------------------------FETDPRCLLTNGKLPLWAKRLLGDDDV-DGATFHA---------KRSYQPHGRWAERA------DREPIKTILDARDLNYYFSPVNPDVLEDSGLEKVEPQSLTQLLTETE-----------------GQEGGSQREGSFQHPDFLQLDLESP-KSNDIIIYNLESEAIPGK---SEYRLKEADVSSS-QRGNGYLR-----------------GPTVLTGELDSCTLEQQPEGGESLESEAETEAETVDLEGGFKAILSSSPQPKAE-KSSFDPIPQAP--ESTSEVELS-GSEGPGPPGSSLPQTPE--QEKFLRHH------------------------------------------------------------------FETLTDAHPEELFNDTLKDVEPPEMDADSEKSFFLNSRLSMSTQFLSRFQKNSRFAHTFPPTLPLQLVKPLEAVVLRREGGKSV----RTNRSCNNAEASDGLPGEKEAESPETPEP-----ASWCPLASGITGIGPNPPPEALLGLPLE-------------------------------------------------KERERKPKRSPPLPSSVARGSRALPARSYAEATMSSRAKMSRS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSLGENVVPALY-------------------------------------------------------------------------------------------------------GLKRPLSMGELSTLGRDGLPSRTRELNSLE---GNQNQPPWGN------------------------------------------------------------------------------------------------------------------------------HEARAGLRLDLTNVSDQFLLP------------------------------------------------LAPTVIPGPPETGLGRGWTKGSIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVEAVPAEFLASDTPTEMKAPGLYEPDFLQRLS-----------------------------------------------------GPEPPARAHTESPAAMESRGPRCIGSEAPLLDPP----------------PAQ---LG-----------MSSVECITQKLQRSFQEALDLYNMVVSSPRMGGQQQQVLAELSSTFLWIQGQLDAMAWLCGEEVVQPPSPSLSPALSPAQGLALAPAPASAWTLSPSPAVSPAPGLPT-PLLWSLPSSEVRALLEHYSELLVQAVRRKAGGRELRAGQGSRA >Ornithorhynchus anatinus_WDR62 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVTLEKVLGIT--AQNSSGLDCD--------------------------PSTGQIAYLAGCLL--------------------------------------------------------------------------------------------------------------------------------------CDKHGSKHR-GRYESVGPRKTLSAVSFSPDGKFIVTGE---NGHRPAVRVWDVDEKTQ---------------VVQLLGHKYGVACAAFSPSVRYIVSVGSQHDMVVNVWDWK----VPNRDGAGD-----EGATGLGSSEPRPLRAP--GSEPALWTNEATEAQRSEMTSTVPLVGRSGILGELHNNVFCGVACGRGQLAGTTFCVARSGLLCQFNEKR-----------------VLERWIDLKVS-------LSSCLCVSDELIFCG-------CTDGTVRIFRARDMHYLLNLP-------KPHHLGIDVAQGPEPG-SFLFSRRAESVYPDTVALAFDPCRRWLSCVYKDHSVYVWDVG---DLKKAGKVWSNLFHSSYVWNVEVYPEFED-------------QRACLPSGSFLTCSSDNTIRFWNVDG-------------------DTRAGDPGN--------------------------------------------GFSHDL----------------------------------------LKVVYVEND---IEHLQDGAHPPDR----------SEAGGCV------DVKAGVRVMQVSP-GQHLASGDRSGNLHRIHELKFMGELIKVEAHDAEVLCLEYS--------KPE-TGVTLLASASRDRLIHVLNVE--KNYNLEQTLDDHSSSITAVKFAG-NRDLQMISCGADKSIYFRRAQ---QLT-PNIKFLGPKNRVKSFKFYEFHFRPARPSRPPAHPLLHP--RVYNTASGKQKKCYKGSQGDDGS-LLKVGRG-----------PRGPGSGT---PVGKHLLSPFCVQNTVCLSSLIWTTEKIITG--------MKFTY-------DCRHLITVS-----------GD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Anolis carolinensis_WDR62 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVLLEKVLGIT--TQTSSGFACD--------------------------PNTGQVAYPTGCVV--------------------------------------------------------------------------------------------------------------------------------------VILNPRKNK-QRHIFNTSRKTVSALSFSPDGKYIVTGE---SGHHPAVRVWEVEDKTQ---------------VSELHGHKHGVACVAFSPSMKYLVSVGYPHDMVVNVWDWKKGTLIASNKVSSK-----VMAISFSEDS-YFVTVG--HRHVKFWFLDVAREIK--IKETVPLVGRSGLLGELHNNIFCDVACGRGRMARSTFCISFSGLLCQFNEKR-----------------VLEKWIDLKNIQ------LLHFLKVSLANCICISEEFIFCGGAGTVRIFQTHNLHYLSDLP-------KPHPLDVNVASCTKCIRLHSPVTRPDAIFPDSIALAYDPCHHWLSCVYKDHSVYIWDVK---DFSRVGKIWSDLFHSSFVWNVEVYPEFED-------------HQSCLPAGSFLTCSSDNTIRFWSLEN-------------------DTQTHFPRN--------------------------------------------IYSNNL----------------------------------------LEVLYVEKN---TQQLQDTTNAPD----------RGENTNHL------DAKSGVHVMSVSPDGQHLASGDRAG-NLRIHELRCMGEVMKLEAHDSEVLSLEYS--------KPE-TGMSLLASASRDRLIHVLNVE--KNYKLEQTLDDHSSAITAVKFTG-SGDVKMISCGADKSIYFRNAQ---KVSLMGLTFVRTHHVAGKTTLYDMDIDITQKYVAVACQDRNV--RIYNIASGKLLWGYKGSQGDDGY-LLKVQFD-----------PSGTFLAT---SCSDKSISIIDFHTGECVAKMFGHS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Columba livia_WDR62 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGHGGQEGP----LGAPPCPPPCP------------LMSPQVTLEKVLGIT--VQSGSGLACD--------------------------PATGLLAYPAG------------------------------------------------------------------------------------------------------------------------------------------------------------KTLSALAFSPDGKLIVTGE---TGHRPAVRVWDVEERAQ---------------LAALHGHKHGVACVAFSPSARYLVSVGAPHDMLVNVWLWKKEALVASNKVSCS-----VTAVSFADDR-YFVTVG--HRHVKFWFLDPAREMK--VTMTVPLAGRAGLLGELHDAVFCAVACGRG--SGATFCVSSSGLLCRLNHKR-----------------ALEKWIVLK----------RRHVPISTS----------------MHRPPQHPKYTPKTSAR-------TPHP---------------PPNRRGDPVYPDTVALAFDPVRRHLSCVYKDHSVYVWDVS---DLRRVGTVCSALFHSSVVWSVEVYPEMEG-------------RRSRLPPGSFLTCSSDNTIRAWSMESGGGHGRAWGDFEQAWGDFEQDLGNFERISVILSRIWGDFEQVWGDFEQDLDDFEQIWGDFEQDLGDFARISVIFEQDLGNFERISVIFKQVWGDFEQDVGDFEQIWGDFEQIWGDFERISVIFEQVWGDFEQDLGDSDRVSHPQPLLGTIHVEQPAQQLP------DARAGVRVLQISPDGEHLASGDRAG-TLRIHELRFMREVAKVEAHDAEVLCLEYS--------KPE-TGAALLASASRDRLIHVLNVA--KNYKLEQTLDDHSSAITSVKFAG-NGDVQLISCGADKSIYFRNAQ---KLP-DGFNFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNV--RVYSTASGKLRCCYKGSHGDDGS-LLKVQLD-----------PSGTFVAT---SCSDKSISLINFHSGECVAKMFGHSGSVPLP--------KAPTP-------PFFHKTPPKSAPVTSPGPRRGDNPFCIFIWHLGPKITGTMRQQLLELERAKEP--------------------------------------HGRDPDVTVPSGDIPLFR---------------PFFIHPP-------------------------------------------------------------------------------------PAPACVLTNGRLPVWAKRLLG-ELEDATEPLPP---------RSSYRPRGRWAEGL------ADR-----------------------------AVEPGSLEQLLAE----------------------AESSGSDLAEESQILDDSQITA--DSQITGEPQITGDSPQEPESPPGPGLEEPKRPGVTLSPSPLS-----------------PSPPCP--------HRPRPHRPCLRHP----------LVPIALIPITPLSPPPSSHCSVSPTCHLPSRHHVTEPPLR-PVSPEEPVSPREPVSPE--EPVSPEEP------------------------------------------------------------------LSPREPVSPEELVSPGEP----------------VSPREPVSPEEPVSPEEPLSPREPVSPREPVSPGEPVSPEDVVTGQDDTL-------SCISLHSQSSMLEGDTGDN----------------------------------------------------------------------------------------------------ARGDRRDKGHGVIKECRVTRVTKGHEVPVTAR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRRRCHRGATNPPPDPP-------------------------------------------------------------------------------------------------------------EPFGASLKDLKPPEEEKSSILNPRLSISSWFL------------------------------------------------------------------------------------------------------------------------------SRCRKNRWVARPSVRP-----------------------------------------------------RVRPVSPTPSLVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVVGHPGPPETAGESEKDENLGETGTET-----------------------------------------------------GDWPKRGFFSPKRPRREDAAPAG----------------------------------------------VERVTAALGELRTRCQDALSVY------DQVGTQKRGEKPNLGG----FGG--------------------------------------------------HSRHPPR----------HEDRFWGHLWKGPPKKWGDKGYG----------- >Latimeria chalumnae_WDR62 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGHLPAVRVWDVEEKVQ---------------LAETQCHKYGVSCVAFSPNMRYIVSVGYQHDMIVNVWEWKKDSTIASNKVSSK-----VTAVSFSEDSSYFVTVG--NRHVKFWYLDASKERR--INATVPLIGRSGLLGELRNNYFCGVACGRGKMAGSTFCITSAGLLCQFNEKR-----------------LLDKWIDLRIL-------ISNCISVSEEFIFCG-------CGDGTVRVFKPQNLHYITSLS-------KPHYLGVDVAKGIEP--SLLFTKKLDAVYPDTIALSFDPQRCWLSCVYSDHSLYVWDVN---DTKKVGKVWSGLFHSSCVWSVEVYPDLEGD------------DRACFPPGSFLTCSSDNTIRLWNMER--------------NNPAVPHPTAFHRN--------------------------------------------IYSHDL----------------------------------------HKVVYVDDD---LQFLQCTAGGSERLD----------GGSTT------DMKSGIRVMKISPDGQHLASGDRRG-NLRIHDLHVLHEILKVEAHDAEVLCLEYF--------KLD-PGLTLLASASRDRLIHILNVD--NGYSLEQTLDDHSSSITAVKIVASDDEMRMISCGADKSIYFRTAQ---KSV-DGIQFSRTHHVVGKTTLYDMDIDSTHKYAAVGCQDRNI--RVYNVISGKEKRCFKGAQGEDGT-LLKVQMD-----------PSGTLLAT---SCTDKNISIFDFYTGECVGTMFGHSE-LVTG--------MKFTN-------DCRYLITVS-----------GDS--CIFVWRLDSQMTDCMRNRLEEIKQTRRQE------------------RTPQRKQPVP---------IRRETYIAVPCPTQPQIEEEDDSEEDVEDD--ESLQTPIKDPSGA------------------------------------------------------------------------------DDMDPAFLLTNGGLPLWAKRLEAGENCIQNLVEQNP--------KKIYRPHGRWAESA------DQDLLKRILETMPLQPTLTP--------------TPSRVTLERGP----------------------LDSFPFEQEGREEFKPQNLENLLEEMES---AAADQQRGEHFSRPDLIPLEN-IDGANVDLESPDS-----------------SENILY------PLQLEDELLNSCRRKLE-----DSERLGPQVLGPCITSLHACCVGSADSQSSSVEQQQDGNSFTM-HIWGGILFFGS----------PYVLHR------------------------------------------------------------------TCSFN-VDSLGQLSSDEGSSELEEET----------------------------------EEVWGSLPQEASIPQTPEQEKFLKQHFETLAEDLIEEKFDRSPKDLKPTEDHGNDIF-----LHPR---LSISARFLSRCQKNS---------------------------------------------------------------------------SFSRWYPSLFGLTSITLLKYFLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IRKLDVKHCYTNRKTCN------------------------------------------------------------------------------------------------------------------------------------KAGYFVELI------------------------------------------------------------------------------------------------------------------------------ALVYR-ITGIAAGYREG-------------------------------------------------------IFISQPLAFS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFRKPS-TQYKETSQNKTGRERSFMVA-----------------------------------------------------TASSRAKMSR--SQSMGENLNLKSSEEQSKQSFMSRATSNMDLVGTATENLPPKQNGQNN-----PSYGNHQARVKL----------------TLNIQKVASDQSLMP----------PPLISAVTKVKQ-----------------------------------KPHEPLKTLVSAVTP----------------TEMKSLGIDKSCYVNEL-------- >Danio rerio_WDR62 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADGAVNFGASMNQSCLTSRAK----KANNNSTSVPANTRRKTRQSHRRDIHNRVVLEKVLGIT--ASSSSALTCD--------------------------PNTGLVAYPAGCVI--------------------------------------------------------------------------------------------------------------------------------------VILSPKKNK-QTHIFNTSRKTFSALAFSQNGKYLVTGE---SGHMPCVRVWDVAERTQ---------------VAEVQCHKYGVSCVAFSPNGSYIVSVGYQHDRTVSVWEWKKGTVIASNKVSSR-----VLGVSFSEDNSYFVTAG--NRHVKFWYLDASKERR--VNSTVPLIGRSGLLGEHQNSQFCGLACGRGSMASSTYCITHTGLLCQFNSNR-----------------QLDSWVDLKTT-------SAQCLSVSGTFVFCG-------CADGTVRVFSPQDLRYITTLH-------RPHCLGVDVSQGTQP--GHLFSANPEAQYPDTLALTFDPVTKHLTCVYNDHSVYVWDVR---DIRNVGKVYSALYHSGCVWSVETYPELEDP------------SAACLSPGSFLTCSSDNTIRLWRSE---------------SPQSHSAALGLRHN--------------------------------------------LYSQDI----------------------------------------VRIVYVDDD---TQYLKAEA---EKAE----------GGAGQ------DGKSGIRVLGISPDGQHLAAGDRSG-NLRIFGLQFMDELQKIEAHDSEVLCLAFS--------PAE-TGLHLLASASRDRLIHIFDMD--SKCNLVQTVYDHSASITAVKFTGLNSELCMVSCGADKSVYFRSAE---KTS-DGLVFSRSHHIVEKTTLYDMDLDATRTHTAIACQDRNI--RVYNVKSGKMKKCFKGSMNDDGT-LLKVQLD-----------PSGMFLAT---SCSDKNICVFDYESGECVATLFGHSE-IVTG--------MKFSQ-------DCRHLITVS-----------GDS--CVFVWRLDSQMTNSMRKRLAERKQQAGLR------------------LQRAPTKQEV---------IRRETYITVPCNALTHMEEDGLMAEVNPEDGLEDCRTPDRLDSTD------------------------------------------------------------------------------ASLDSVVLQTNGKMPMWVRRLG-GEGEKDGTGAAN---------RVQYQPQGRWAVQS------DPLAIRTVLEMKSNQLPLSH--------------TPSRVMGEEEL----------------------EEDPRFHPQSLDSLLDEDLEDGEEEEEEKICGVSSDGFSSSLHGPEFLQFPHGEENFNPELSSSEK-----------------TGYILY------PAN--STALSTGEGEFD-----VKALCEGTAGDPDEEELSPDSACSAESPESHSDQPHDQDTDSL-SQVSSTGSSGVEEDEEE--SGTLLRQH------------------------------------------------------------------FDTLG-VATNEKFNTDLSSLQPTTESNF------LNPRLSISTRFLSRFQSRFRSAACRPAACLSSIPDESTDSQTLDQTMEKPKHLSNSGSVEEKEKTVIKRRSSMSSRRSSNPSL-----LRWKNALGEITNKNQSTTQSTTS----------------------------------------------------------APGVLSNKSTSNSCDASVTRSRQSYMGPTASSRAKINQS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSVESLNLCISEETPLNAL------------------------------------------------------------------------------------------------PNVEHSKENMIPPSSPVVSSAPLHQSPVLGNHSARASLRLDLI------------------------------------------------------------------------------------------------------------------------------GHNRASLSPVSLKSRRGKVEHHD---------------------------------------------SPRRQALVTPTEMR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLGKESRKQISNIEQSLAPSDRLSTGA-----------------------------------------------------GMFSRSPMVRQTSDTVFEDLQSVRSDQTSVSSPMTNAVS-QDNQDSADNNSIPEETGLSA-----EALSVQMCKEMVNELWHTIHKATDLYSKLCSIPELSEQQEQMKGVLQEVFVGVQSELNSICPQKT-----------------------------------QPSTKSTRPISEDSPGRQLRDDRAVALLEKYSEMLLLRMTEKGAQATLE------- >Homo Sapiens_MAPKBP1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVEGSTITSRIKN-LLRSPSIKLRR-SKAGNRREDLSSKVTLEKVLGIT--VSGGRGLACD--------------------------PRSGLVAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLFNPRKHK-QHHILNSSRKTITALAFSPDGKYLVTGE---SGHMPAVRVWDVAEHSQ---------------VAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSR-----VTAVSFSEDCSYFVTAG--NRHIKFWYLDDSKTSK--VNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRR-----------------LLDKWVELRNI-DSFTTTVAHCISVSQDYIFCG-------CADGTVRLFNPSNLHFLSTLP-------RPHALGTDIASVTEA--SRLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVR---DPKKVGKVYSALYHSSCVWSVEVYPEVKDS------------NQACLPPSSFITCSSDNTIRLWNTESSGV-----------------HGSTLHRN--------------------------------------------ILSSDL----------------------------------------IKIIYVDGN---TQALLDTELPG------------GDKADA----SLLDPRVGIRSVCVSPNGQHLASGDRMG-TLRVHELQSLSEMLKVEAHDSEILCLEYS--------KPD-TGLKLLASASRDRLIHVLDAG--REYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQ---KSGDG-VQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNI--RIFNISSGKQKKLFKGSQGEDGT-LIKVQTD-----------PSGIYIAT---SCSDKNLSIFDFSSGECVATMFGHSEIVTG---------MKFSN-------DCKHLISVS-----------GDS--CIFVWRLSSEMTISMRQRLAELRQRQRGG------------------KQQGPSSPQR-----ASGPNRHQAPSMLSPG-PALSSDSDKEGEDEGT-EEELPALPVLAKSTKKAL-----------------------------------------------------------------------------ASVPSPALPRSLSHWEMSRAQESVGFLDPAPAA---------NPGPRRRGRWVQPG------VELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPR-----KHGQEA-------------------LETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEE-GVFAQDLEPAPIEDGIVYPEPSDNPTMDTS---------------EFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSP-EHPTEDSESTEPLSVDGISSDLEEPAEGDEEEEEEE-GGMGPYGLQEGSPQTPD--QEQFLKQH------------------------------------------------------------------FETLASGAAPGAPVQV-PERS---------------ESRSISSRFLLQVQTRPLR---EPSPSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVEPSSG---NPSPQQAASVL-----LPRCRLNPDSSWAPKRVATASPFSG-------------------------------------------------------LQKAQSVHSLVPQERHEASLQAPSPGALLSRE-IEAQDGL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSLPPADGRPSRPHSYQNP------------------------------------------------------------------------------------------------TTSSMAKISRSISVGENLG--LVAEPQAHAPIRVSPLSKLALP------------------------------------------------------------------------------------------------------------------------------SRAHLVLDIPKPLPDRPTLAAFS--------------------------------------------PVTKGRAPGEAEKPG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPVGLGKAHSTTERWACLGEGTTPKP-----------------------------------------------------RTECQAHPGPSSPCAQQLPVSSLFQGPENLQPP--PPEKTPNPMECTKPGAALSQDSE-------PAVSLEQCEQLVAELRGSVRQAVRLYHSVAGCK--MPSAEQSRIAQLLRDTFSSVRQELEAVAGA-----------------------------------VLSSPG-------SSPGAVGAEQTQALLEQYSELLLRAVERRMERKL--------- >Branchiostoma floridae_XP_2613182 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTLERVLGLT--LTNN---------CGLAS-----------------SPVTGVIAYP---------------------------------------------------------------------------------------------------AGCVV-----------------------------------VLFNTKKNK-QSHIFNTSRKTISALAFSKDGKYVVTGE---SGHQPGVRVWDVEEKTQ---------------VAEFQGHKFGVSCVAFSSNMKYVVSVGYQHDMLVNVWNWRTSTLVASNKVSSK-----VKAMSFSEDSSYFVTVG--NRHVKFWYLDESKASKN--LGTVPLLGRSGILGEQRNNFFCDVACGRGMMKESTYCITRSGLLCEFNERR-----------------LLDKWVELRTT-------CANCISVSENHIACG-------CADGVVRLFDPKTLHYICTLP-------KPHYLGLDVAASIDP--SQFITKNDNAKYPSTIAVKYDEQNNKVTCVYDDHSLYVWDVK---DEKKIGKAWSFLYHSSCVWGVETYPNVPEG------------FKAALPAGSFITCGSDDTIRIWNL-DSTLH----------------TDTVLKRN--------------------------------------------IYSNEL----------------------------------------LKVIYTDESYQNIRDVDYNPGKSSS----------TVTIYGG--------KNGVRCVKVSPDGQHLASGDRCG-NIRVHELQFMDQLKYLEAHDGEVLCLEYA--------NPDQTGLNLLASSSRDRLIHIFQAD--RNYSLLQTLDDHSAAITAVKFTDHNGQLQMLSCGADKALMFRSLQQGPTNTNTDMQFIRNHYILGKCTFYDMDVDITKKYVATACQDRNV--RIFNTNSGKLKKGYKGSLGDDGT-LIKVQLD-----------PSGMYAVT---SCSDKNLSIYDFYSGECVATMFGHSELVTG---------VKFTP-------GLKRLISTS-----------GDG--CIFVWKLSPVFTQTMKDRLAELG------------------------QQLPTDVP-------------------------------KINIRSG---------------KSSWLRT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Saccoglossus kowalwvskii_XP_2734815 MYRPKPGETEEDLLRFQEEFLRKQNVSSAKLTKNSDNKGEPSTKNPDPKTTLKRDVVKLDDSSTVSPGDVPRKKSKFKSSQRESNVSSSSSQRVYFDLDGNNHDNMHKEMDQRDSHITSVLSDIIERDIRDVPVYLPRAMNQAFPSAFHRGKQDDKRLKDVPEKKRPSLFAQHFSRTKPSEFGMISEMKQVEVPNVTSKIHSKTIDNVRNIAKNPESNESGQEEKMEVEENAVGQMASLPVTPLVITGEGLDQVESSKEAIKIHKENLTKLSEMPEAEILAEQKQLKSMLDPNIVAFLASKKQKTTSSPSMDTSNAETTAKIPHGNEQVVEQTMSSPKSGTSPITSRKGWVHMDTVEKEKLEWMQEVPKPKTGEKKIGVQARFNLHGVIIARDSDISMREGLHHHGEEPEVPGYTLEEMFQLCRSAALNQRILSLQILAKVLYNYRLDRLGGDLQVALIPHLLDAGLIFILRQSLDDTSEVGIAAAVDAFKSVLIQPADEECLDKVYGWYRGCEVHPLFLSKEEDEDEEDADSNKKEKHEIEILEQDVIKGLLKMKFLERLRYILEICRPDPTVVINILLLLIRLARHSPEASHEIMKCPRLMSTIFTMFLPTTWTPTDRSIIDDVYGFPVHHAMKLVRVLCMAGRNIAAIILSRYNLMSVIIRYITQEPTDMQLHVGEAFMLSIESLPQEDVNERKPTIPVPAIDWSHVTGFIAPIELCYHRWITEISRTDEPLSDQGLMLAASCINAMSAFYIKITQQTSYNAPDVLQHIETIVDKTVLPFMKSGNFYNYVINLRTYSSYKINDEDRPRKTGCASLPDLSGHPLDDNRHPCIQNGSPYPFMISYLRLIYTWAKMHKGIAAKFAGTIESSYVITYLERTCENSRLVGDTLDRCYSRYEHIVLYYLVKLYQLVAEQTESCRRYSKLYHSVALLLFTSLHSGDEHLAHDLMSTVLFHTHYLVEGRIGDPEAIELAELLRVSDTSERTNTCDTMRKREPNRGVLLRDSYNSLPSIRACYMSSFGGMTQTIAKSRNLFTVIPHEIETFILPEFSGSLVPLDWMYLPLLHFYNQASKNELLGQPVENLPSQFVNGVTNTLRMIYMLETWRPESVNHISMSAKITRLMCVF--LTGNDLFLEDTVHCYLLALLKLYFQPSYLDRLELNSPIPGVASFYDFYMVFVVQYGGVSFGDSLFATFMLLPLQQRYNIEFRKAIWGEHQHVIRAITLKIDECLLPMHRYLTPQESHVELLQLYLSALVSNVVKSTWSPVLYLIAVCHVNGFLFSRHDNQDQEMMKRQFIMLKQVLRIQNQVCDRMFNPRKNK-QTHIFNHSRKTITALALSPDGKYVVTGE---SGHMPAVRVWDVAERSQ---------------VGEFAGHKFGISCVAFSPNLKHVVSVGSQHDMVVNVWDWKTGIRAASNKISCK-----VTAICFNETGNCFVTVG--TRNVRFWYTSSKKSRE-----AVPLHGRSGILGEQRNNFFCDVACGKGSNKEKTFCITTSGLLCEFDEKR-----------------LLDKWVELRTP-------QAHSLSVSEKYIFVG-------CANGVIRIFSADTLHYVSTLP-------KPHILGVNVAASMDP--SHLVKHNDNAKYPAAVALTLDDKNNRLSAVYNDHSLYVWDVR---DIKKIGKSWSFLYHSAPVWGIDVYPNIPDG------------NKSLLPAGSFITCSSDNTIRVWNINEQATS----------------TDGTFKRN--------------------------------------------IFS---------------------------------------------------------ELSGHDNAKTD----------AITVED---------KKGVRCTCVDHSGQHIAAGDRSG-NIHIYDFNFSEEICQIEAHDAEVLCLTYS--------KPE-TGYVLLASASRDRLIHVFNVK--EDYKLMQTLDDHSSSITAVKFTVAY-----------------------IHTNPDLQFIRTHHLNGKTTLYDMSVDATQKFVVAACQDRNL--RIYNIASGKQKRCYKGSVSDDGT-LIRVELD-----------PAGVYATT---SCSDKTICVYDFYAGECVATMLGHSELVTG---------IRFTH-------DSKHLITVS-----------GDG--CVFVWKLPIMFTQHMKERMAELGKVQKVEPAYNMLRRGTYTAMPKVIPGMPAPVPDTTDGDSVLEQLLSEPFMSSTETLLQEEGSEQTNNVSGEEVLSPNTYSSPSQPKGRWAQRVDAKGFRLKSEWEDQNAIQLSMASCMDRRRLTVEPDTLYEQVSQIRLISYDSKLKNSLTGDVCKESDVIAEDDIEDEDEEFLPAGLRLPQLEQQLAEDEIASGRVTKSRGSDPFICPFVRPETDGSNNSESPS----TPDREVAATLAGALMNLENSEEDDEKDDDKEVIIYLPSEEESAKSENGEFCVTEN------VESMKMYAKRFKKVPRSSSAERKMSLESTESDSTDKMGIISVDNSDEDDEERPDTPFEEQKDEQTDDEEKEKVFLKNNYENLAEEKFETNIDQLEVTGNSYMQQLQSGRLSISTRFLTRAQQNHLRRLAAAALERDNISSDEASESEDDSLQKRQQEMARAVEETRRRLQEMGYGAGSKKKTSPEEKIPGTLRKRSGGICIVSTEPEIQVPAVTLPQDDDSMLSDNKDENELSNVKTQSTAGIGAAAAAARVVPDTLNLSIINQVDSVTKPESMPTECSAHKPDVKSLPTKIARMLPSPSSIASRQASAEIHISSSMPSLETTQSSPPQHIANKENIVDISDQSPRIQRSRSRSESGKIGMKDLKAGKFESKSETSSPTHTMTLRKRSKSQDSLDRAGTTSNRNRAARRAR-------------------------------------------------TERHLPPLPISKSHSAPPVGHVAVPRTRNSFSGETESSQAKRT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSYAAGTKSSLAKINQADS------------------------------------------------------------------------------------------------ATSSPRTLRKKSYPLSPEHKDNDESSKTTKDSNDRFVMPPPST------------------------------------------------------------------------------------------------------------------------------NVVNKTKTTSRRSYSDPKSRNYSK------------------------------------ARRFPPNSPKKDSRSLTISDPSSISKLLESKATGEGTAVVKPPINGTRDKTQKQTLCLAEKSKISEKCDEH-----------------------------------------------------------------------------------------------------------------------------------------------------------------MPVIAESKQEIKSPPQQLSVEDVTDNIAPLISVTTGL-----------------------------------------------------IIEEKAVKSVKHDKIKTDTPNTVKTGISEIQCSNNEPKAEENKSEMATAAPPLTTDVNSPTDSSVSLMTMALCTKTAEELQHVFSKAVQLHSQVLNETYPEQEKTQMLSALQSTFTTMQETLTNIEPTLTN-------------------STPKQSPTSLLTQDEVSKLKTSIALTNGKREDPQVAEAAISLLDQYSDMLVSLVKQKIAVDNTPT------ >Drosophila melanogaster_FBpp0305221 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTPASLSASTPTLSTLHHQRMALQSQSQSPLASPLTPSPSSVFGSPKFPANYERSEKIKLKKVLGLT--VCSNAALDVS--------------------------PVSGLLAYPAGCTV--------------------------------------------------------------------------------------------------------------------------------------VLFNAKRQT-QAYLVNTSRKAFTSVAFSRCGRYVATGE---CGINPAIKVWELETPNG-----SLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSK-----VAAVCFSEDGSYFVTVG--NRHVKYWYLEGGRKYK----DPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRR-----------------LLDKWVQCRTT-------NANCICVNERFILVG-------CAESIIRIFNSATLEYVTTLP-------RTHYLGVDVAQGIQIN--HIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLR---DISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQ-----------TLPEECFVTCSSDDTIRVWGLDGCTN------------------NDIYRRN--------------------------------------------IYSKEL----------------------------------------LKIVYSDDE---LQFIKDQGSSLFDK----------AGNSS------YDGRNGVRCIKISPELQHLASGDRCG-NIRVYSLVNLRLLTTIEAHESEVLCLEYS--------NEK-IERKLLASASRDRLIHVFDVA--QNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQG--------NIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNV--RVYGTQNAKQTKTFKGSHSDEGS-LIKLSLD-----------PSGIYVAT---SCTDKTLAVYDYYSNECMARMYGHSELVTG---------LKFTN-------DCRHLISAS-----------GDG--CIFIWQVPHDMIVTMQARMSQQRLRSGHAP---------------LPRPLAPISPPDGIVLESPTSEIEQPQLQPKFG---------------VAERFSDVGQLPQWAMRKAAADSDSGA---------------------------------------------------------------------LSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTG----------LAPRARGRWAQRST--QLETADDLRSNSES-PLGTVSSVGG----HSGVNVQTSDYNSASSKDITYNQTYLSE-------------DSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYN-NLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLPQSSTN------------------------------------------------------------SFLHAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEELLQVINKVKQQLENGTRKNGNTRLNAIAEVGHRP-LRGSHSISDLSLAANLDGSRNAGGGPGRYQKPVDSHDTSQYTSPQNTTATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQHQQYAPPASQQFFNCAAPKSKLQQNFQTMRQVQQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTSAMRSHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEEVEWSAEGNERGALLGEPKRHSVYADDARTILDMIHADTEKMIDEITRKYGDLDEPGIPASYSMPANLRNLGGLGSTGDSTPTGRTTQYYVYREFYQCERKVSLSDILQPEQFAASQRRLDEARFLETQRHSSASFFLTGQQSQESLSLLSDGDGPGSYCNSLESVLSDESDCQSAPLEYPQTQVAVLQQRHAGIRNFIIHGPVSKSYGNSPNAYGSFDYYMRQQHSTTTDSFDVTGYNLEPLKPLPSSKTYPRIAQVQASENIPTLRSKNKQYTSGVNKSLSTDFAQQRQQRNSNPMQSGDNLFVRKPLKPKPPVPAKPHNLVSTLSHMEKQQKQKSQSRTASVVQQFEHNLQKFEKEKQREREQQRRPAMRSSVSSGALAGGSTTQSCLKKVSRFDTSESSRRATSVRQKNRPKISVRFNTVSQIKYTPSAKRERQAREEEPPEMEVGSLPSDYGERSFEMYFAENGNAPENLENMQTLKLYTKPQLQAVVDEIQQEREKYRKNLDNAGKISGKGGSGKGKGAGSSTSHQCQNIAKKIDIIEKLIAMEENKMEQIRLATESRLRPFNCNAKEKGYVKSLTMNFDMLARGEDPTEDEDLASKDASDLCAYARNIRRNCSLPDVLESTDFTGIYNSQGVELAKEVIADDESGDPVNPGITADSADHDGIGQTVVLRMEPGNPKTLNPMPIEESSIRRACSLSDLHMGNFGKPGKSQNGTPQKPQVQHRNGNVSRSASKRNSLQGKTGLGASSNSMNVLNQGSDSEPEDSNRLRSASNGQGRSNGPIAANRQYSNKINNVNNNRRKTPNFSSATPMQDDSSSEETPNSTVN---NKPIVPPRPRNLAFDHKSKLMINNSGSPGGNAKQRSGVTSTEDFEGTD--PEAQVHNVINKLYTTTQAAMQLHANLK-----------NTLLLKELENALIMSRNMLSSITN--------------------------RQADKTNNGGGGLGVGGSGGLNHDQLNADNGDYLMMVNNCADLLSNLRTKHKPDDCENNS----- >Anopheles gambiae_XP_320082 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLQIKLKKILGLT--VCSSAGLDVS--------------------------STTGVLAYPAGCTV--------------------------------------------------------------------------------------------------------------------------------------VLFNSKKLS-QNFLLNTTKKAITAVAYSECGRYLATGE---CGHNPSIKVWELDASGGPGGGGAIENGTAGSIVAEFSGHKYAVSCVAFSPTGKYLVSVGSQHDNIVNVFDWKANLKIASNKVTAK-----VVAVSFSEDGNYFVTVG--NRHVKYWYLEGSRKYK----EPIPLMGRSAILGELRNNDFCAVACGKGEMAESTYAITRNGHLVEFNARR-----------------LLDKWVMCRTN-------AANCMVASTKYILVG-------CAEAIVRVFNAETLEYITTLP-------RTHFLGVDVAQGVHIN--HMMAVPQNAKYPDTIAIVYDEARSKVTCVYNDHSLYIWDLR---DIRRVGKSQSFLYHSACIWGVETVPFSYQQQLRQHNGGAANGAGDTLPSDCFMTCSSDDTIRVWDVDSCET------------------NEVYRKN--------------------------------------------IYSKEL----------------------------------------LKVLYIDDE---LNFIKDTDNPIHST----------EKNSS------YDGRNGVRCIKISPDSRQLATGDRSG-NIRIYNLSNLKLITTIEAHDSEVLCLEYT--------NEK-IERRLLASASRDRLIHIFDCE--ANYRILQTLDDHSSSITSVRFIGAGKQFQMVSCGADKSIIFRHFQN--------NVFLRGNNCSGKNTLYDMEVDSNSKHILTACQDRNI--RVYSTQNAKHTKTFKGSHSDEGS-LIKVSLD-----------LSGIYIAT---SCTDKTLSVYDYYSNECMARMYGHSELVTG---------LKFTN-------DCKYLISAS-----------GDG--CVFIWQVPHDMIVTMQARLSQQALRSGLQP---------------IPRTLQPTNPFTDAILNHPQPTPPAPSSVSEFGSPPNSAFLVDDAPGTPGYRFSDVGQLPQWAKRKPSEDLQS----------------------------------------------------------------------------------------SSPVLGSSPSQTGANFGG----------LAPKPRGRWGQKGVGGQLEDPFDLRNIVESSPLGTTFVAPGQPIHPPATNTPTSGYNSSGSKDV-YSNAYLSE-------------DSSIDSGRENRRPDLSSFLHKKITETKALNSLN----SESN-------------------------------TEHDGDVEDISDGERTSSDHGMVYYPSAAPSTPTDFKINEIDTNELRKSIRRQKLEKQGLSLAAQFQS-----AASGTGTGTSDDEDEGSTPSGDNADRSLASTLGGSSESIPQQTSS------------------------------------------------------------TFLQAVLD-GPGSLSDRERS-QARKSMSAKHNN----DAKITTSISKSFANNKKEELMKVINEAKAKLEN---------------VGYRSGLRASHSISDLSHSMNMSG--------------------------------ASPNRTQR------------------------------------------------------------------------------IGGNPRSLISAQDSESSIR--------------------------------------------------------------------------------------------------------------------------------------------RACSLSDLS-----------------------------------------MGKGKASGQYKPSVS----------------------------------------------------------NRNTSTPT-------------------------------------RNTPKRSTSSVGK-------------GGASLSTG--MGVR-------------------------------------------------------------------SISVGMLN---------------QASDS--------------------------------------EAEPAGTRGGLL---------------------------------------------------KPTISSQNKING---TGNGTGPGS---------------------------------------------------------------------------------------------------------------------------GGKYINP----------------------------------------------------------------------------RSAAG--IINRRKGLQNAYSSVNISTAG------------------------------------------------------QDESSSEESPTSTVSTVPAKPAVPPRPRSIAFEHKR---IANASQLNVKKTVTVGGTTTIPADATTNVTNQLCTNIINQLVQTTSTVIQLHQRLKSSDEASINGRNNSLMLKELENAVIMTQNMLTKVTN--------------------------RNHN--------------DGINNNSMSN-NTNNQIMYEKCVDMLNQVQKHVN-----NNG----- >Amphimedon queenslandica_XP_3384409 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSKRPVLAKKRKQKKEEEKVVLDRVLGLT--CSNGNSLSVS--------------------------SAGSCLVYPAGCTV--------------------------------------------------------------------------------------------------------------------------------------VLYYPKRSK-YGHIINPSKKPISCLSLSSDGKFVAFGE---CGHNPAVQVWDVVSSPP-------------THLVSLKGHAFGVACLGFSPNGRYLISIGYQHDQNIHIWNWRGGVKLASNKITSKQ----VFGLAFSQDGSCFVTCG--SRRVRFWYFDTNQRYKS--TLTHPLNGRSAILGDHQNNTFISVRCGHGRHSGLTYSLTKSGLLCQFNSSR-----------------ELDKLTDIKSG-------RAYCLEYSESFIMCG-------CGDGVVRLFDPATLDYIVTMP-------RPHPLTVQLSFGLQSTVASQQFITEPGKCPDTVALGYDNNNNKLVAVYNDHSLYIWDLK---NLKAIGKTHSFLYHNACVWDVQAYPPLANG---------------VIPSLSFITSSSDNTVRFWNLTESNG------------------SETQLKN--------------------------------------------VYSKEI----------------------------------------FHIIYTDDT--DTTCLRDTSLLPGDS------------------TAVADASRGVRSIQFSPEGRHLAVGDRQG-NLRVYDLQFMDKIVEVVAHDSEILSVQYSPEVFVFAIEIQQGNRMLLATGSRDRLIHIFDVS--DNYNHVHTIDHHSASITAVNFSISQDTLYLYSCGADKSLFFYTLD-------KNGSFKRAHHIAEKSSMYDMIVDPTSSLIATASQDKFL--RVYGITTGKLKNSCKVCEDEGTTGLLKLSLD-----------CSGSYVAV---SGSDKCVYVLHFITGELLCKIQGHSEVVTG---------LMFSN-------DSSYLLTTS-----------GDS--CVFVWRLSLDMKENIRRRLKENKQTAYLEY------------------YTPQTIPTP------TTPTLTTPTLATPMPVDRRETYVIPKADKDGAHSLDETDVPDEEGED----------------------------------------------------------------------------------EEGFRFSVSKLPSWAQRTVYSRPSIAATVGVET------------KKGGEGVTVPP-------PPDGTAVAGRWAERVTAEQFIMIEDKDASSEGESS------------------------------EAEIEMVETRDSPENTENIKVEKDEDGETNSSLEEEKEEETLMKQVMEKLLEEEEEEDTTDSQTQP-------------------------------SVTDSLMSNEELVYPKSTGRDSVDPSMFKVTTPERRASVKNVAELVSPTEKKVGEEEEEEESPDSTCSTPETNIKSLGTLIVDESAFLRTH------------------------------------------------------------------FESLTAEKADLIFGPAPETDS---------------PGVGPTRGFSPPCSRPSISAIYYNRRRSFTTGCIKIRPVTSSTSTNYASPELTDNRYRTLPTSPRSTETESVIDISSEETS-----------------------------------------------------------------------------------------------------------EPKTLTVEEERKEEEGEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQGRDVSDGDDDSSKSHETGETGNIVRFRPRGRVVKR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKITREEITKTRKRLEELGYSEFAE-------------------------------------------------------SSKAKEAIEGEVKSVEDVHVDQTGQDDNKKEREEEEEHGARESVVKETDAQSLVEDDD--------KVSFDELCNRSLSLSTDNSTKLQSLISTSLQTLSSRLSDIRQSATLDSLTTTTNPPTSQPKP--------------------------------------------------AALPGAESLEPFLENLSERLIAMMKEKLEKSED-------- >Drosophila melanogaster_FBpp0076646 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGDSHDVCRQLLPRAIFGIN--GKVENGVRQHP--------------------------VTGSIIFALGNKI----------------------------------------------------------------------------------------------------------------------------------------GIADYKKNTQEFVAGHTNTISCLDLSKSGKYMASGQINHMGFRGYVIIWNYDQRK---------------EIARHDLHKVSVQAICFTAQDRCVVSIGGVDDGSVIVFDMEAFSPICQTPASRAISGNALTVRPLHNNPYFFVTAG--DRHLRLWSILR---------EEKKLYVQDVLMASKTRVFYC---ARINKTDEFAYLGTGTGDIVKIVLNCCDRDHVSKQGSTSCILGAFGTHNP--RK-PTGRDCNRYVNGVRALYVLEG----------GRLLIGAGNGDIELVEERTDVPLINFRDYPGPTWPYLRT--------LKKTHVSGRISSFVRS-KTDMFYICTDTNEIYGLNIK------TWVLKLLRTCHTKSVYCITFP----------------------KNYSGVFATSGKECIRIWSSGRK---------------------------------------------------------------------------------------------------------------------QELLRIMVY-----------------------------------------NFNCACVRFTHDGTSIVSVWNDGIIRAFTPITGRLIYAIPNAHNKGCSALAVA------------SSGRLIVTGGIEGQVRVWKID-PYRQDLVGVLKDHSGPITSLDINY-LDTEVISACTDGSCVIWDIKR-----------MTRKQVVTANTQFMSASYFPTGVQVITCGSDGRII--YWMVYNGALIRELTASKKSSVN---CLAIN-----------ETGDYFIT---VGSDLQVKLWDYNSGAVVGIGSEHASSVISC---------AYSP-------CMTMFVTGS-----------TDG-----------------------------------------------------------------------------------------------------SLII------------------------------------------------------------------------------------------------------WDVPRDFWGRPNPPDVTKYSLPKTSSKTRMSDVQSRVNSGTNLKTSKGENIDGLLKATPKDDLCCVECPPCAKKDTKGVDPYAECGIVPDVRKC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Apis mellifera_XP_624617 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDIKELEVFGIIAFD--GIMRNGLKLHP--------------------------DGEHLVYPMGNKV----------------------------------------------------------------------------------------------------------------------------------------TVKHVKTGEQFFFAGHKNFVSALCISSSGDLIASGQVNHHGFKAMVIIWDYVNRK---------------MKLSYEIHKVRVEDVCFTENGKYLISLGGRDDGRIIVWDIENETPLCSTSIGNESFGNITLIARTNVCQTSFMTAG--DKTLKLWRIDL---------EERKMYGTDVKIGKMKREINC---LVINETDEYVYCGTTSGDIIKARLNIEKSKEIT---KYPVMIGCYSKIPTQKRK-TNSQNGEIYAGGVKNLLLLEK----------EKLIVGAGDGTVELIEIIKE-SKLTAKITKALVIPAIMT--------YCSRNVCGMVTSMVRY-KNEFILVGTALCEIYEIELS------RFHMRLIVTCHTNSIFDVAFP----------------------RNYSEIFATTSKNDIRVWKLITQ---------------------------------------------------------------------------------------------------------------------KELLRISVP-----------------------------------------NFICSSICFNCNGNSIISAWNDGAIRGFALNGGKLLFEINGAHTKSVSTITIT------------NDDSKLISGGCDGQVRIWDAK-SEIRYLLQVLKEHRGPITSLQVSP-DNESLISSSTDGTCILWNLRN-----------FTRKFMLRGNTMYMATCFVPNGVQILTCGTDRKIA--YWETLDGSLVREIEGSLTGTLN---TISIS-----------HDGQYFLT---GSDDSIIKLWEYRTANTIRLSLAHAAAVTRC---------VFAP-------DDTFIVTAS-----------ADG-----------------------------------------------------------------------------------------------------AIMI------------------------------------------------------------------------------------------------------WKYP-----------FSEKLINKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Anopheles gambiae_XP_315945 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSIEEPTEMMTLEPSAIIGFD--GHVVCGLRVHP--------------------------DQRHLVFPLGNEI----------------------------------------------------------------------------------------------------------------------------------------SIYECATNKQSFLRGHTNTISTLDISTSGRMVASGQSNHMGFRAFVIVWDWETRK---------------EISRHELHRVRVQSLCFSSNDQFLVSLGGKDCGSIIVWDIEQRTAICGTIATKETTGEATKVASLNKRFTTFVSGG--DQNLRVWNIDR---------ERKRLTVQDVAVGKLRREFTG---MRISPNDDTLYVGTMSGDIVKINLNCNPNPSDPSQDKMPVLLGCFGKHNA--KK-PPGKDCEKYHYGVRDLLLLPD----------GKLIIGAGDGTIDMVQERNG----NFKNYRGPTWPELKS--------LQSTKIDGVITSLQIR-NGKTLLIGTNGCEIYSLELANF----SSSLRLLKTCHTNAVYDIAFP----------------------YNFSLVFATASHESIRIWSTSKM---------------------------------------------------------------------------------------------------------------------QELLRIVVP-----------------------------------------NFASSSIVFSRDGKSIISAWNDGVIRAFTPLSGKLIYAIPNAHNKGCSSVAVT------------SNGKIVVSGGIEGQVRVWKID-PYVQSLIGVLKEHYGPIESVHINN-YDTEVVSASRDGSCVIWDLIR-----------LTRKHVIFAHTQFIAAQYFPTGVQILTAGSDKLIG--YWEAYDGSLVREVEGSKSGPIN---AIDMN-----------MMGEYFVS---AGTDQIVRLWNYQLGVEVAVGIGHASAITSA---------RYSP-------NGKFLVTGS-----------SDG-----------------------------------------------------------------------------------------------------GIFV------------------------------------------------------------------------------------------------------WKVP----------EVSIWWWWWWFV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Amphimedon quaeenslandica_XP_3385435 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGGDKTSEQLEMVNTIGFN--GRVPNGLHVHP--------------------------GGEHIIYPLGSTV----------------------------------------------------------------------------------------------------------------------------------------IIQDLASKKQQFLAGHSNYISCLACSPSGQYLASGQVTHMGFKADAIVWRFNDDDER-------------IYCRLTLHRVKVQAIAFSPSDKYLATLGGTDDNSLVIWDLEKKCALCGHEAAMQSAGDVYTIAFSKKSDSILATGG--DLTLRVWEVCVT-------EKTRKVVPTDCNLGQLKRIINS---IEMCDDGSSMLCGTSTGDTLLVNVNT----------------CLLKEYGP---------QKEKYSLGVSVLKVLPS----------GDFLIGTGNGTVAALR--------------GKTYKCF-----------KSATVEGSITSIAVRGSGHQFLVGTSVSQIYLFQFND------FTYELLRSCHADLITDICFP----------------------RESSELFATSSHNDVRVWHSNTS---------------------------------------------------------------------------------------------------------------------KELLRIQIP-----------------------------------------NLLCNALEITPDGKGIITGWDDGKIRVFLPESGKPAYTIHNAHSKGVTALSVT------------SNSKSIISGGGEGQVRIWDIFSANNQKMKIALKEHKGAISCIKIRR-DDLECVTASTDGTCIIWDLVK-----------NTRAQVLFANTLFKAICYDLQECQVITGGTDRKIG--YWETYDGSQIRELEGSQTGSIN---GMDMC-----------QN--LFVT---GSSDKLIKLWKYNEGEVTHIGIGHSGEINRV---------KVSP-------DGRHIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AIIR------------------------------------------------------------------------------------------------------WRMPVHLLENEEEGAEGKVTGSTEPNEKPITDEEEEKEEEEREEEGDGETVIKQEEEEEEKEGEREEGTPAPNVETE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Pongo abelli_MAPKBP1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVEGSTITSRIKN-LLRSPSIKLRR-SKAGNRREDLSSKVTLEKVLGIT--VSGGRGLACD--------------------------PRSGLVAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLFNPRKHK-QHHILNSSRKTITALAFSPDGKYLVTGE---SGHMPAVRVWDVAEHSQ---------------VAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSR-----VTAVSFSEDCSYFVTAG--NRHIKFWYLDDSKTSK--VNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRR-----------------LLDKWVELRNI-DSFTTTVAHCISVSQDYIFCG-------CADGTVRLFNPSNLHFLSTLP-------RPHALGTDIASVTEA--SRLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVR---DPKKVGKVYSALYHSSCVWSVEVYPEVKDS------------NQACLPPSSFITCSSDNTIRLWNTESSGV-----------------HGSTLHRN--------------------------------------------ILSSDL----------------------------------------IKIIYVDGN---TQALLDTELPG------------GDKADA----SLLDPRVGIRSVCVSPNGQHLASGDRMG-TLRVHELQSLSEMLKVEAHDSEILCLEYS--------KPD-TGLKLLASASRDRLIHVLDAG--REYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQ---KSGDG-VQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNI--RIFNISSGKQKKLFKGSQGEDGT-LIKVQTD-----------PSGIYIAT---SCSDKNLSIFDFSSGECVATMFGHSEIVTG---------MKFSN-------DCKHLISVS-----------GDS--CIFVWRLSSEMTISMRQRLAELRQRQQGG------------------KQQGPSSPQR-----ASGPNRHQAPSMLSPG-PALSSDSDKEGEDEGT-EEELPALPVLAKSTKKAL-----------------------------------------------------------------------------ASVPSPALPRSLSHWEMSRAQEPVGFLDPAPAA---------NPGPRRRGRWVQPG------VELSVRSMLDLRQLETLAPSPQDPSQDLLAIIPSGPR-----KHGQQA-------------------LETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEE-GVFAQDLEPAPVEDGIVYPEQSDSPTMDTS---------------EFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSP-EHPTEDSESTEPLSVDGISSDLEEPAEGDEEEEEE--GGMGPYGLQEGSPQTPD--QEQFLKQH------------------------------------------------------------------FETLANGAAPGAPVKV-PERS---------------ESRSISSRFLLQVQTRPLR---EPSPSSSSLALMSRPAQVPQASGEQSRGNGANPPGAPPEVEPSSG---NPSPQEAASVL-----LPRCRLNPDSSWAPKRVAITSPLSG-------------------------------------------------------LQKAQSVHSLVPQERDEAGLQAPSPGALLSRE-IEAQDGL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSLPSADGRPSRPHSYQNP------------------------------------------------------------------------------------------------TTSSMAKISRSISVGENLG--LVAEPQAHAPIRVSPLSKLALP------------------------------------------------------------------------------------------------------------------------------SRAHLVLDIPKPLPDRPTLAAFS--------------------------------------------PVTKGRAPGEAEKPG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPVGLGKAHSTTERWACLGEGTTPKP-----------------------------------------------------RTECQAHPGPSSPCAQQLPVSSLLQGPEDLQPP--PPEKTPNPMECTKPGAALSQDSE-------PAVSLEQCEQLVAELRGSVRQAVRLYHLVAGCK--MPSAEQSRITQLLRDTFSSVRQELEAVAGA-----------------------------------VLSSPG-------SSPGAVGAEQTQALLEQYSELLLRAVERRMERKL--------- >Mus musculus_MAPKBP1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMAGEGSTITSRIKN-LLRSPSIKLRR-SKAGNRREDLSSKVTLEKVLGVT--VSGGRGLACD--------------------------PRSGLVAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLFNPRKHK-QHHILNSSRKTITALAFSPDGKYLVTGE---SGHMPAVRVWDVAERSQ---------------VAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSR-----VTAVSFSEDCSYFVTAG--NRHIKFWYLDDSKTSK--VNATVPLLGRSGLLGELRNNLFTDVACGRGEKADSTFCITSSGLLCEFSDRR-----------------LLDKWVELR-------TTVAHCISVTQEYIFCG-------CADGTVRLFNPSNLHFLSTLP-------RPHALGTDIASITEA--SRLFSGGVNARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVR---DPKKVGKVYSALYHSSCVWSVEVYPEIKDS------------HQACLPPSSFITCSSDNTIRLWNTESSGV-----------------HGSTLHRN--------------------------------------------ILSNDL----------------------------------------IKIIYVDGN---TQALLDTELPG------------GDKADG----SLMDPRVGIRSVCISPNGQHLASGDRMG-TLRIHELQSLSEMLKVEAHDSEILCLEYS--------KPD-TGLKLLASASRDRLIHVLDAG--REYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQ---KSGEG-VQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNI--RIFNISSGKQKKLFKGSQGEDGT-LIKVQTD-----------PSGIYIAT---SCSDKNLSIFDFSSGECVATMFGHSEIVTG---------MKFSN-------DCKHLISVS-----------GDS--CIFVWRLSSEMTISMRQRLAELRQRQRGI------------------KQQGPTSPQR-----ASGAKQHHAPVVPPSG-PALSSDSDKEGEDEGTEEEELPALPILSKSTKKEL-----------------------------------------------------------------------------ASGSSPALLRSLSHWEMSRAQETMEYLDPAPVA---------NTGPKRRGRWAQPG------VELSVRSMLDLRQIETLAPSPRGPSQDSLAVSPAGPG-----KHGPQG-------------------PELSCVSQNERAPRLQTSQPCSCPHIIQLLSQEE-GVFAQDLEPAPIEDGIVYPEPSDSPTMDTS---------------AFQVQAPTGGSLGRMYPGSRGSEKHSPDSACSVDYSSSRLSSP-EHPNEDSESTEPLSVDGISSDLEEPAEGDEDEEEE--GGTGLCGLQEGGPHTPD--QEQFLKQH------------------------------------------------------------------FETLANGTAPGGPARV-LERT---------------ESQSISSRFLLQVQTSPLR---EPSLSSSGLALTSRPDQVSQVSGEQLKGSGATPPGAPPEMEPSSG---NSGPKQVAPVL-----LTRRHNNLDNSWASKKMAATRPLAG-------------------------------------------------------LQKAQSVHSLVPQD------EVPSSRPLLFQE-AETQGSL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSLPQAGGCSSQPHSYQNH------------------------------------------------------------------------------------------------TTSSMAKLARSISVGENPG--LATEPQAPVPIRISPFNKLALP------------------------------------------------------------------------------------------------------------------------------SRAHLVLDIPKPLPDRPTLTTFS--------------------------------------------PVSKGLAHNETEQSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLVSLGKAHTTVEKHSCLGEGTTHKS-----------------------------------------------------RTECQAYPGPNHPCAQQLPVNNLLQGPESLQPL--SPEKTRNPVESSRPGVALSQDSE-------LALSLQQCEQLVAELQGNVRQAVELYRAVTSYK--TPSAEQSHITRLLRDTFSSVRQELEVLAGA-----------------------------------VLSSPG-------GSPGAVGAEQTQALLEQYSELLLRAVERRMERRL--------- >Rattus norvegicus_MAPKBP1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMAGEGSTITSRIKN-LLRSPSIKLRR-SKAGNRREDLSSKVTLEKVLGVT--VSGGRGLACD--------------------------PRSGLVAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLFNPRKHK-QHHILNSSRKTITALAFSPDGKYLVTGE---SGHMPAVRVWDVAERNQ---------------VAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSR-----VTAVSFSEDCSYFVTAG--NRHIKFWYLDDSKTSK--VNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRR-----------------LLDKWVELRNT-DSFTTTVAHCISVSQEYIFCG-------CADGTVRLFNPSNLHFLSTLP-------RPHALGTDIATITEA--SRLFSGGANARYPDTIALTFDPANQWLSCVYNDHSIYVWDVR---DPKKVGKVYSALYHSSCVWSVEVYPEIKDS------------NQACLPPSSFITCSSDNTIRLWNTESSGV-----------------HGSALHRN--------------------------------------------ILSNDL----------------------------------------IKIIYVDGN---TQALLDTELPG------------GDKADG----SLMDPRVGIRSVCISPNGQHLASGDRMG-TLRVHELQSLSELLKVEAHDSEILCLEYS--------KPD-TGLKLLASASRDRLIHVLDAG--REYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQ---KSGEG-VQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNI--RIFNISSGKQKKLFKGSQGEDGT-LIKVQTD-----------PSGIYIAT---SCSDKNLSIFDFFSGECVATMFGHSEIVTG---------MKFSN-------DCKHLISVS-----------GDS--CIFVWRLSSEMTISMRQRLAELRQRQRGI------------------KQQGPTSPQK-----ASGAKQHHPPVVPPSG-PALSSDSDKEGEDEGTEEEELPALPILGKSTKKEL-----------------------------------------------------------------------------ASGSSPALLRSLSHWEMSRAQENMEFLGPAPTA---------NTGPKRRGRWAQPG------VELSVRSMLDLRQLETLAPSPRGPSQDSLAVSPTGPG-----KHSPQA-------------------ADLSCASQNERAPRLQASQPCSCPHIIQLLSQEE-GVFAQDLESAPIEDGIVYPEPSDSPTMDTS---------------AFQVQAPTGGSLGRVYPGSRGSEKHSPDSACSVDYSSSRLSSP-EHPNEDSESTEPLSVDGVSSDLEEQAEGEEEEEEE--GGTGLCGLQEGSPHTPD--QEQFLKQH------------------------------------------------------------------FETLANGAAPGGPARA-LERT---------------ESRSISSRFLLQVQTSPLR---EPSLSSSGLALMSRPDQVSQVSGEQLKGSGATPPGAPPEMEPSSG---NSGPKQVAPVL-----LPRRRTNLDNSWASKKTAATRPLAG-------------------------------------------------------LQKAQSVHSLVPQD------EVPS-RPLLFQ--AEVQGSL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSLPQADGCPSQSHSYWNP------------------------------------------------------------------------------------------------TTSSVAKLARSISVGENPG--LAAEPQAPAPIRTSPFNKLALP------------------------------------------------------------------------------------------------------------------------------SRAHLVLDIPKPLPDRPTLTTFS--------------------------------------------PVSKGLAHSETEQSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSVSLGKTHTAIEKHSCLGEGTTPKS-----------------------------------------------------RTECQAHPGPNHPCAQQLPVSNLLQGPESMQPL--SPEKTRNPVESSRPGAALSQDSE-------LALSLQQCEQLVAELRRNVRQAVQLYHSVTSCK--TPSAEQSHITRLLRDTFSSVRQELEALDGA-----------------------------------VLSSPG-------GSPGAVGAEQTQALLEQYSELLLRAVERRMERRL--------- >Monodelphis domestica_MAPKBP1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPAVRVWDVVEHHQ---------------VAELQEHKYGIACVAFSPSSKYIVSVGYQHDMIVIVWLWKKNVVVASNKVSSR-----VMAVSFSEDCSYFVTAG--NRHIKFWYLDDSKTSK--VNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRR-----------------LLDKWVELRDT-DSFTTTVAHCISVSQDYIFCG-------CADGTVRVFNPLNLHFLTTLP-------RPHALGTDIATITEA--SRLFASPADAKYPDTIALTFDPTNQWLSCVYNDHSLYVWDVR---DPKKVGKVYSALYHSSCVWSVEVYPEVKDS------------NQACLPPSSFITCSSDNTIRLWNTESAGV-----------------HGCALHRN--------------------------------------------ILSNDL----------------------------------------IKIIYVDGN---TQALLDTELPGN-----------GDKTDG----SLVDTRVGIRSVCISPNGQHLASGDRVG-TLRVHELQSLSEMLRVEAHDSEILCLEYS--------KPD-TGLKLLASASRDRLIHVLDAE--REYSLQQTLDEHSSSITSVKFAASDGQVRMISCGADKSIYFRTAQ---KSGDG-VQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNI--RIFNISSGKQKKLYKGSQGEDGT-LIKVQTD-----------PSGIYIAT---SCSDKSLSIFDFTSGECVATMYGHSEIVTG---------MKFSN-------DCKHLISVS-----------GDS--CIFLWRLSSEMTISMRQRLAELRQLQRGG------------------KPQGLSPSRR-----ASGLNSRDAPTALSVV-PALSSESEKDGEDEGTEEEELPALPILAKGAKKEPP----------------------------------------------------------------------------ASARGPSLPRSLSHWEMSRTQEGVEFLDPVPAS---------SQGPRRRGRWAQPG------VELSVCSMLDLRQLETLSSVPRPPSQDSLAQESVAQDQPVLEKNSQRS-------------------TVDAHSSQNGSVPKSLVSKSCACSQVIQLISQEEEGVSAQELEPMNNEGGVVYPEPDSCPLLDSRSCPLD---------GEFQVQALPHGPLGSVYPVNRSTEKHSPDSACSVDYSSSRLSSP-DHPNEDSESTEPLSVDGISSDLEEPAEGEEDEEEEEDGGSGSGGLQGGSPHTPD--QEQFLRRH------------------------------------------------------------------FETLANGAAPDGPGQP-LERT---------------EPQSISSRFLSRVQTPRIR---EPPLSFWRPVAQQRPIRVFQAPSEKPHSGAICFPGSPPEPEPEPEPVCSVSHPQNMTSM-----LRRRRLNLDGSWTHKRTKTALSGSGSN-----------------------------------------------------LQKAQSVQNLGPQD------EPPLLGPGPPPENDVVQEGL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPQTQGDVCPARPRSYLNS------------------------------------------------------------------------------------------------TTSSMAKMSRSSSVGENLGQGELAETQVPNPVRITSVNKLALP------------------------------------------------------------------------------------------------------------------------------RRAHLVLDIPKPLPDRPNVASFS--------------------------------------------AGAKSQALWETQQLG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPESLGKKSVTAVGQACLGEGSTLTP-----------------------------------------------------RTESQAQPGPKSSCSQELPANCLPRSPEDLQPP--SPEEIPNPMEPPRPGASLSQDSEPV-----MVVSMERCQHVVAELRSSVHQAIQLYRLVVRTS--SPSAEESTIKHLLEDTLSLARQDLESLTGV-----------------------------------PTASPS-------GSAGALATDQTQALLEQYSQLLLQAVQRRMQGRL--------- >Gallus gallus_MAPKBP1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVV--------------------------------------------------------------------------------------------------------------------------------------VLFNPRKNK-QHHILNSSRKTITALAFSPDGKYLVTGE---SGHMPAVRVWDVAERTQ---------------VAELQEHKYGVACVAFSPSSKYIVSVGYQHDMIVNVWSWKKNIVVAANKVSSK-----VTAVSFSEDCSYFVTAG--NRHIKFWYLDDSKTSK--VNATVPLLGRSGLLGELRNNFFADVACGRGKKADSTFCITSSGLLCEFNEKR-----------------LLDKWVELRNT-DSF-TLTAAAHSYIHDLIFCG-------CGEHSINLAIITLLHIFACLP-------RRGCLS----SVSHL--IRLFSGTTDAKYPDTIALTFDPTNQWLSCVYNDHSLYVWDVK---DPKKVGKVYSALYHSSCVWNVEMYPEVKDS------------NQSCLPPGSFITCSSDNTIRLWNTESSNI-----------------HGTALHRN--------------------------------------------ILSNDL----------------------------------------MKIIYVDDN---TQVLLDTDYNSGG---------STDKADT----QVMDTKVGIRTVCVSPSGEHLASGDRIG-TLRIYELQSLQEMLKVEAHDSEILCLEYS--------KPD-TGLKLLASASRDRLIHVLDAG--KDYSLQQTLDEHSSSITSVKFAANDGKVRMISCGADKSIYFRTAQ---KTGEG-VQFTRTHHIVRKTTLYDMDVDPSWKYAAIGCQDRNI--RVFNISSGKQKKLYKGSQGEDGT-LIKVQTD-----------PSGLYIAT---SCSDKNLSIFDFYSGECVATMYGHSEIVTG---------MKFSN-------DCKHLISVS-----------GDS--CIFIWRLSSEMTINMRQRLSDMKQR---G------------------KQAEKSPPHK-----TAGLMRHESISALSSV-PALSSDSDKDGEDEGNDEAFDGPPHSGKCSGICLFPF----------------------------------------------------------------------------PDPDLTLSRSLSHWEMRRAKEIAAIQRSEAPM---------SKVPRQRGRWSQPTN----NIEMTVKSMLDLRQLESFSVS-RSPSRDSLSQNSNGDD------REEQA-------------------DLPTHINKVGSSIAPQDNRSCVRPQVIRLLSCEE-GIFSQELEPSESEECVIYPEQDEIHPTDPRS--------------EFQVKALPHGKLNRSYQSNGCPDKHSPDSACSVDYSSSRLSSP-DHPNEDSESTEPLSVDGIS-DLE-----GEEGEED----VGTSVPVGEIPQAPD--QEKFLKQH------------------------------------------------------------------FGTLGSTDGKGTALWS-LERT---------------ENLSISSRFLS--QSPALR---RLSLSSSNLILDSKSIESPAPTSRFTQDLLKNDSSHPADALENSHLLNNVNLHQAVYAQ-----KKRKSALETSRVGMAPGRVIASFPEGPV-------------------------------------------------NAVMRKAQSVHDLVHEVNSMELSVSTKSPLRALSSSLLKMDGS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GALLAKDVRAAKPKSYMNP------------------------------------------------------------------------------------------------TTSFRAKMSRSISVGENLY--LGYSTDVLTDGRTSPPVKLASS------------------------------------------------------------------------------------------------------------------------------NRAHLILDIPKPLPDRPTLASFS--------------------------------------------PTTKTKTLLEPQSPQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPAGACKKENSTG-LAKESPVESPIS-----------------------------------------------------RTGCQFEPGVTNLKLREFSEVRQLKSPESTLPR--YPIRPRSPTSVTALAQVS----E-------SSISVEQCEHVVSELQDSMRKAIHLYRAVLNDT--ESSTDKDKIAGLLTETFSLMKKELDSLKSL-----------------------------------NDKCGANL-----PSPKSLGDEQTLALLEQYSELLLQAVERRMDKKL--------- >Taeniopygia guttata_MAPKBP1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTLEKVLGIT--VSGGRGLACD--------------------------PRTGLVAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLFNPRKNK-QHHILNSSRKTITALAFSPDGKYLVTGE---SGHMPAVRVWDVAERTQ---------------VAELQEHKYGVACVAFSPSSKYIVSVGYQHDMIVNVWSWKKNIVVAANKVSSK-----VTAVSFSEDCSYFVTAG--NRHIKFWYLDDSKTSK--VNATVPLLGRSGLLGELRNNFFADVACGRGKKADSTFCITSSGLLCEFNEKR-----------------LLDKWVELR-------TTVANCISVNHDYIFCG-------CADGTVRIFNPT-LHFVTTLP-------KPHFLGTDIASVTEA--SRLFSGVADAKYPDTIALTFDPTNQWLSCVYNDHSLYVWDVK---DPKKVGKVYSALYHSSCVWNIEMYPEVKDN------------NQPCLPPGSFITCSSDNTIRLWNTESSNI-----------------HGTALHRN--------------------------------------------ILSNDL----------------------------------------MKIIYVDDN---TQVLLDTDYNSAG---------SADKADA----QVIDTKVGIRTVCVSPSGEHLASGDRIG-TLRIYELQSLKEMLKVEAHDSEILCLEYS--------KPD-TGLKLLASASRDRLIHVLDAG--KDYSLQQTLDEHSSSITAVKFAANDGKVRMISCGADKSIYFRTAQ---KTGEG-VQFTRTHHIVRKTTLYDMDVDPSWKYAAIGCQDRNI--RVFNISSGKQKKLYKGSQGEDGT-LIKVQTD-----------PSGLYIAT---SCSDKNLSIFDFYSGECVATMYGHSEIVTG---------MKFSN-------DCKHLISVS-----------GDS--CIFIWRLSSEMTINMRQRLSDMKQR---G------------------KQAEKSPPHK-----TAGLMRHESISALSSV-PALSSDSDKDGEDEGNDEDENAVVKLAISEKACVD------------------------------------------------------------------------------CDPDLTLSRSLSQWEMRRAKELAAIQRSEAPM---------SKMPRQRSRWSQPTS----SIEMTVKSMLDLRQLESFSVS-RSPSRDSLSQNSNGDD------REEHT-------------------DLPVHINKVGSSIPPQDNGSCVRPQVIRLVSFAS-RLLMNGLTHCSVHDGRGAPRKSDS-PFGTSI--------------EFQVKALPHGKLCRGYHSNGCPDKHSPDSACSVDYSSSRLSSP-DQPNEDSEGTEPLSVDGVS-DLE-----GEEGEED----VGTSVPEGEVPQIPD--QEKFLKEH------------------------------------------------------------------FGTLSNTDGKGGSCRN-LERT---------------ETLSISSRFLS--QSPALR---RLSLSSSNLTLDSKPIEPPTQT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------SGISIEQCEHVVSELQDSMRRALHLYRRVLNDM--ESSTDKDKIAGLLTETFSSMKKELDSLKDA-----------------------------------EERPKD-------KEALSLGDEQTLALLEQYSELLLQAVERRMDKKL--------- >Anolis carolinensis_MAPKBP1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVV--------------------------------------------------------------------------------------------------------------------------------------VLFNPRKNK-QHHILNSSRKTITALAFSPDGKYLVTGE---SGHMPAVRVWDVAERTQ---------------VAELQEHKYGVACVAFSPSSKYIVSVGYQHDMIVNVWSWKKNIVVAANKVSSK-----VTAVSFSEDCSYFVTAG--NRHIKFWYLDDSKTSK--VNATVPLLGRSGLLGELRNNFFTDVACGRGKKADSTFCITSSGLLCEFNEKR-----------------LLDKWVELRNT-DSFTTTVANCISVNHDYIFCG-------CADGTVRIFNPSNLHFVTTLP-------KPHFLGTDIASVTEA--SRLFSNVTDAKYPDTIALTFDPNNQWLSCVYNDHSLYVWDVK---DPKKVGKVYSALYHSSCVWNIEVYPEVKDN------------NQSCLPPNSFITCSSDNTIRLWNTESSNI-----------------HGTALHRN--------------------------------------------ILSNDL----------------------------------------MKIIYVDEN---TQALLDTEYNTAG---------GVDKADS----QILDAKVGIRTVCVSPTGEHLASGDRIG-TLRIYELKSMKEMLKVEAHDSEILCLEYS--------KPE-TGLKLLASASRDRLIHVLDAG--RDYSLQQTLDEHSSSITAVKFAANDGKVRMISCGADKSIYFRTAQ---KTSDG-VHFTRTHHVVRKTTLYDMDVNPNWKYAAIGCQDRNI--RIFNISSGKQKKLYKGSQSEDGT-LIKVQTD-----------PSGLYIAT---SCSDKNLSIFDFYSGECVATMYGHSEIVTG---------MMFSN-------DCKHLISVS-----------GDS--CIFIWRLSSEMTINMRQRLADMKQR---G------------------KQAEKAQPGK-----TTGLTRHESASALSSI-PPLSSDSDKEGEDEGNEEDELQGLQSFQMQTKCNAE-----------------------------------------------------------------------------RDSDLSFSRSLSHWEMRRAKEMAMIECSEATM---------SKAPRQRSRWSQPTS----TIEMTVKSMLDLRQLESFSVS-RSASHDSLSQTSNGDD------QEERP-------------------DLPLHANNVGSSSAPQENQPCVRPQVIRLVSCEG-GIFPQELEPSESEECVIYPEQDEMHPTDISS--------------EFQVKALPHGKLGRGYHNSGCPDKHSPDSACSMDYSSSRLSSPNEVSTLDSESTEPLSVDGTS-DLDEQV--GEEDEED----VSPGHLEGNAPRTPD--QEKFLKQH------------------------------------------------------------------FETLAGDKIPGGPYRT-LERT---------------EN-SISSRFLS--QSPALR---QLSLSSSNLILDRKPSEGLAWSRHVSPGLVKNGIDGQNSAIENGIFQNDVHSFRSLYMQ-----RKRKPFLEISRG---AGRPVRTFPDTDG-------------------------------------------------ELVMRKSQSVHDLVHNGEKD----PRPNNYRPLSTTLLKMDGS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSLQAKDSKTTKPKSYMSP------------------------------------------------------------------------------------------------TTSFMAKMSRSISVGENLC--FGDSSENLTEVKVSPQGKLAS-------------------------------------------------------------------------------------------------------------------------------NRGHLILDIPKPLPDRPTLASFS--------------------------------------------PTARSKTLLESESPQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPAGVGRKKCLFT-EEWPSKLEIQAS-----------------------------------------------------VPKASPASPSTHTLKENQMSLRTKVQPESPGPN--SRPKPSELRSPTALGAIAQDSGG-------SSISVEHCRHVVSELQDSMRKAIHLYHMVSADM--GTSADKDEIAGLLTDTFSVMKKELDSLN--------------------------------------EGSGSAL-----SSPRHFGDEQTLALLEQYSELLLQAVERRMDKKL--------- >Pelodiscus sinensis_MAPKBP1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMSVEGSTITSRIKN-LLRSPSIKLRR-SKPRNKREDISNKVTLEKVLGIT--VSGGRGLACD--------------------------PRTGLVAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLFNPRKNK-QHHIVNSSRKTITALAFSPDGKYLVTGE---SGHMPAVRVWDVAERTQ---------------VAELQEHKYGVACVAFSPSSKYIVSVGYQHDMIVNVWSWKKNIVVAANKVSSK-----VTAVSFSEDCSYFVTAG--NRHIKFWYLDDSKTSK--VNATVPLLGRSGLLGELRNNFFTDVACGRGKKADSTFCITSSGLLCEFNEKR-----------------LLDKWVELR-------TTVANCISVNHDYIFCG-------CADGTVRIFNPLNLHFVTTLP-------KPHFLGMDIASVTEA--SRLFSGVADAKYPDTIALTFDPTNQWLSCVYNDHSLYVWDVK---DPKKVGKVYSALYHSSCVWSVEVYPEVKDS------------NQSCLPPTSFFTCSSDNTIRLWNTESSNI-----------------HGTVLHQN--------------------------------------------ILSHDL----------------------------------------MKIIYVDGN---TQALLDTDYNSGG---------NTDKADA----QALDTKVGIRTLCVSPNGEHLASGDRIG-TLRIHELQSLREMLKVEAHDSEILCLEYS--------KSD-TGLKLLASASRDRLIHVLDAG--KEYSLQQTLDEHSSSITAVKFAANDGKVRMISCGADKSVYFRTAQ---KTGEG-VRFTRTHHVVRKTTLYDMDVDPSWKYAAIGCQDRNI--RIFNISSGKQKKLYKGSQGEDGT-LIKVQTD-----------PSGLYIAT---SCSDKNLSIFDFYSGECVATMYGHSEIVTG---------MKFSN-------DCKHLISVS-----------GDS--CIFIWRLSSEMTISMRQRLADMKQR---G------------------KQVEKSPPHK-----TAGLVRHESISVLSPV-PVLSSDSDKDGEDEGNDEDELNGLQSFQIQSTCNTERDLG----------------------------------------------------------------------INGKDPDLSLSRSLSHWEMRRAKEDAEIQRSETAV---------NKMPRQRGRWSQPSS----NIEMTVKSMLDLRQLESFSVS-RSPSRDSLSQTSNGDD------REEHA-------------------DLSLHIGKVGDSLAPQESRPCIRPQMIRLVSCEE-GVFTQELEPFESEECVIYPDQDEIHPTDTSS--------------EFQVKALLHGKLGRSYHINGCPDKHSPDSACSVDYSSSRLSSP-DHPNEDSESTEPLSVDGAS-DLEEQA--DGEDEED----AGTSMVEGEVPKTPD--QEKFLKQH------------------------------------------------------------------FETLANSSEKGGSCRT-LEKT---------------ENISISSRFLS--QSPSLR---RLSRSLSNPILDQKSIGASAQS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQVSPDL--LKNGN-------------------------------------------------------------------------------------SLESPVSALFL-------------------- >Xenopus tropicalis_MAPKBP1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVTLEKVLGIT--VTAGRGLSCD--------------------------PKTGLVAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLLNPRKNK-QQHILNSSRKTITALAFSPDGKFLVTGE---SGHMPAVRVWDVAERTQ---------------VAELQEHKYGVACVAFSPTSKYIVSVGYQHDMIVNVWSWKKNVVVAANKVSSK-----VTAVSFSEDSSYFVTAG--NRHVKFWYLDEAKSSK--VNSTIPLLGRSGLLGELRNNFFTDVACGKGKKSNSTFCITSSGLLCEFNDQR-----------------LLDKWVELR-V-SSIITTVANCILVNHEYIFCG-------CADGTVRIFNPNNLHFLSTMP-------KPHCLGVDIATVTET--SRLFSSAADAKYPDTIAMTFDPTNQWLSCVYNDHSLYVWDVK---DLKKVGKVYSALYHSSCVWSVEIYPEIKDS------------NQACLPPNSFITCSSDSTIRLWNMETSNI-----------------HGTALHRN--------------------------------------------ILSNDL----------------------------------------MKIVLIDDN---TQALLDTEYNSAG---------LGDKVDH----QGLDTKVGIRSVCVSPNGQHLASGDRTG-TLRVHELQTVTELLKVEAHDSEILCLEYS--------KPD-TGFNLLASASRDRLIHVLDAA--KDYSLQQTLDDHSSSITAVKFAANDGKVRMISCGADKSIYFRTAD---KVGDAAVHFTRTHHIVRKTTLYDMDVDPSLKYAAIGCQDRNI--RIFNISSGKQKKLYKGSQSEDGT-LIKVQTD-----------PSGLYIAT---SCSDKNLSIFDFYSGECVATMFGHSEIVTG---------MKFTN-------DCKHLISVS-----------GDS--CIFIWRLSSEMTINMRQRLAEVRQR---G------------------KQVEMSAPHK-----TPNASRRETIAVMSTA-PAMSSDSDKEGVEDGSDEDMAVISFSLHITRSDKT------------------------------------------------------------------------------SSASSSFGRSLSYWEMKRVSVSLSLLQISDCL---------SKMPRQRVRWSQPAG----NIEMTVKSMLDLRQLDSFAPS-----DDVIGFQP----------SEGLG-------------------MEFVDTDNPRSQAPFGPIGNRSRPRVIRLMSCEE-TMFKQDVDTPEGKECTIFPETEEDESLDRCS--------------IFEVKGLP----LRSYHDNVCQEKHSPDSACSVDYSS-RLSSP-EHPNEDSESTEPLSVDANSSDLEEQVEAEDLEPNS-------PLMDGEIPQTPD--QEKFLKRH------------------------------------------------------------------FGNLSTGNFPDGPLLT-SERN---------------DFSSISSRFLAKAQPPALGYRCQDPFRPYNQLLCARARSAKHVAATFVSPSSRHQSIEPSVPDSEFSPALFQPSQELPTLINGTDHQPKSAIMLDHDFASPQKCKGGPFSS----------------------------------------------------LMQIRKTQSVHDLVHEAEREE--KAIRRRTLPSNLIKVENITS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPHAKDGKSAKGRSYMNP------------------------------------------------------------------------------------------------TTSSMAKISRSMSVGENET--VIIKPHLQPVTNCSSTKTFQAK------------------------------------------------------------------------------------------------------------------------------NRAHLTLDIAKPLPDRPLLS------------------------------------------------FNKGKGQLEMESPR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPANSCKVKNSFTELTCRNENHSSGA-----------------------------------------------------VEKISPSEDYGCAPSHLSPSS---LWPIPLSPR--FISQAQNVMEMSCKGHISSQEGS-------SSVSFEQCELIASELQDSLRKALSLYRSVTTADP-STNLERCKIAGLLTETFGMVKRELDFLKEG------------------------------------NGSPGTE-----HTTHRLGDDKTLALLQQYSELLLQAVEKRMDKKL--------- >Latimeria chalumnae_MAPKBP1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVL--------------------------------------------------------------------------------------------------------------------------------------VLVLPHSNSGEEHVFSVLRKTITALAFSPDGKYLVTGE---SGHMPAVRVWDVAERSQ---------------VAELQEHKYGVACVAFSPNAKYIVSVGYQHDMIVNVWAWKKNIVVAANKVSSK-----VTAVSFSESSTYFVTAG--NRHVKFWYLGDTKTSK--VNATVPLLGRSGLLGDLRNNFFSDVACGRGKKADSTFCITSSGLLCEFSEKR-----------------LLDKWVELRNV-DSFTTTLANCISVNEDFIFCG-------CADGTVRIFNPFNLHFISTMP-------KPHYLGMDIAAVTEP--NLLFASKVDAKYPDTIAVTFDPANRWLSCVYSDHSLYVWDVK---DSKKIGKVYSALYHASCVWSIEVYPEVKDC------------NRVCLPPGSFITCSSDNTVRLWNTDGCNI-----------------HGTVLHRN--------------------------------------------IISSDL----------------------------------------MKIVYMDNN---TQTLLDLEYSSPG---------SVEKTDT----QAADTKTGIRTLCVSPDGQHLASGDRTG-TLRVHELRFLGEILRVEAHDSEILCLEYS--------QPE-TGLNLLASASRDRLIHVLDAG--NDYSLQQTLDEHSSSITAVKFAANDGKVRLISCGADKSVYFRTGE---KSPEG-IQFTRTHHIVRKTTLYDMDVDSTRKYAAVGCQDRSI--RIFNISNGKQKKLYKGSQGEDGT-LIKVQTD-----------PSGLYIAT---SCSDKNLSVFNFYSGECVATMFGHSEIVTG---------MKFSN-------DCKHLISVS-----------GDS--CIFIWRLSSEMTINMRQRLAEMKQK---G------------------KQTEKSPPRK-----PSSLIRRETYNIPSPA-AAMSSDSEKEADEDGNEEEESPTLKKKKKKKKKKIP----------------------------------------------------------------------------AHHAEVEYSRKVPTWDVKKVDEVSSVKGSDTAL---------NAKPRQRGRWSHRLS----SIELTVKSMLDLRQLETFTRS-RSASGDSLSQSSVFGDAG---EPEEPD-------------------RSSLQTLVEDSYSSYKESKPRSRPQNIRLPPRQD-GGFPRQVETPQKEERVIYLQPADYNRSHMESQTDCSTPPQSMTPTEYEVKLLQPGKVGKGYRGNSCPDKHSPDSACSVDYSSSRLSSP-EHRNEVS----PLHTRVEMPNLRYCCLAISFPLLC------WRGQGGGDTHTHT--HTRTTKAD------------------------------------------------------------------FVLFWISPFTDLPGRT-QQGC---------------EPLSMSSRFLARSQSPVVSACPKPEWKPASQCPSWSRDRQDAHPFQAHLCPEKAEPYPGEQAHFDRKKNQTACLTKRYQSLS------GNCFSLETNLATVGSQSSLPMAE---------------------------------------------------------KEQRAN--------------PRRTLPSTPLRPDQPSSP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAKEGLQTKAMKQRSYMNP------------------------------------------------------------------------------------------------TTSSMAKVSRSVSMGENLN--FSDSSEHNTSLPNPLSAKPGAS------------------------------------------------------------------------------------------------------------------------------SKPHLTLEIPKHLPDRPSLVSFS--------------------------------------------PTAKPKTHFEVGAPR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPIGVAKRKPSFPDGRPCQGDKVSTP-----------------------------------------------------IQEKMLLLQPQGCFAQELSYTCLNDYPLRGLTRGIAPLPLDVPFSCSKKKIPISQHLVKR-----PAVGVEDCKAVAAELQDSLQKALDLYKAVTSAG--AASLENTQIAGILTESFSHIRKELDTLDCS-----------------------------------KMAERTPQQQEVDLSPSPLRDSRTLELLEQYSELLLQAVERKMNRKL--------- >Takifugu rubripes_MAPKBP1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMTAEGSGTIRSRIKN-LLRSPSIKLRRRSGNARHKEDRGDKIHLEKVLGIT--APGNRALACD--------------------------PQTGLLAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLLNPQKNK-QQHIFNSSRKAITTLAFSPDGKYVVTGE---SGHMPAVRVWDVSERLQ---------------VSELLEHKYGVACVAFSPNGKYIVSVGYQHDMMVNVWNWKKNVLVAANKVSSK-----VSAVSFSNDSSYFVTAG--NRHVKFWYLDHAKTSK--VNSTVPLLGRSGLLGELRNNFFSDVVCGRGKQASATFCITSSGLLCVFNDRR-----------------LLDKWVELRTV-DAASVSQATCLSITDDLIFCG-------CSDGTVRAFSPVDLHFRCTLP-------RPHSLGTDVASMVDA--SQLFSCKPGSRYPDTVAVTYDPAHRWLSCIYSDHSIYVWDIGDVSDLRRVGKLYSALYHSSCVWNVEVYPEGGGG------------AGRGAGPGSFLSCSSDSTIRLWNLGSHN---------------------TINRN--------------------------------------------VLSHDL----------------------------------------QEVIYVDD----INCLLDADCTAVCGG-------SSEKAGPTDGQQADQSKAGLRTLRVSPDGQHLASGDRVG-VLRIHSLDTMEEILNVQAHDSEILCLEYS--------KPD-TGLQLLATASRDRLIHVLDAG--RDYSLVQTLDEHSSSITSVRFTTNEGKVRMISCGADKSVYFRTAE---QTDEG-LEFTRTHHVVRKTTLYDMDVEPTRKYAAVGCQDRSI--RIFNISNGKQKKFYKGSQGEDGT-LIKVQID-----------PSGLFIAT---SCSDKNISIFDFYSGECVATMFGHSEIVTG---------MKFSS-------DCRHLITVS-----------GDS--CIFVWRLSPQLTIRMRQRLADLRLLNSQN------------------AAQQNLVTLRPVCADVMVLTRTRSRDASSPRVVTLSSNSDKEEEEEDQNKVTLPTTPRSVNAT--CCVQG---------------------------------------------------------------------------VWFHQLFLLCFKKALLTSSSLSLGLLQEQVGA---------RTPRRRWSSKDAGSE----DDLLMVKSMLDLRMLESYCFDVKASLTDHLTVVPPPQ------VKTSPS-------------------STSSSCPKGVSPVPELTDKGTTTNHRPNYIRLSSQTPDEEKPVLYPDQWEDT--VILVERTPPLPV-------------SEFQVKEAC-------PAADGQQDKPSPDSGCSLGFNSSLSSPVQP--GEGLSTTEPSSADGNSSGLEEDEEEMG-----------RGAEAQVVLQTPD--QEAFLKEH------------------------------------------------------------------FVTLAELSNPGSPSRASQSSS---------------DNLSISSRFFTQSQTLAARGTGGSEEKVQSEISELQPQMMNQDLLHDQKPKHNQTSKGQTQPPQEAPQN-PPLKKRVQMAA------DSERNQGNPSSELRKTQRVPSLAP-------------------------------------------------------PSSAPHDPPLLSKT---------TPVISFQPPEASSCIAK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPPAGTPPAHVVPRSYMSP------------------------------------------------------------------------------------------------TTSSKAKMSRSVSVGEGIH-----LPEPTEDPSVAPCSQVKET------------------------------------------------------------------------------------------------------------------------------LPAAIAVVPSSAAVATPPHAALA--------------------------------------------TPPHAAVATPPHAAV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APVVVTLSSPLS-SQGNQAVPPTRTL-----------------------------------------------------HTRVPGGSRP-LPDKPSLSSFSPSRPPSVPASL---STPPPQEDETPAEPG-VDSVVSAD-----EPISVETCRALTNDLQRCFRRATHLYRKVSASSGDDSSANQNQMAVILSEAFQAMRVELNGLPLG-----------------------------------PPSMMG----------ELGESKMT-ALLEEYSLLLLQAVERRLDAPL--------- >Oryzias latipes_MAPKBP1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASRSGDAGRTCAMSADG-ATIRSRIKN-LLRSPSIKLRR-SG-ARHKRDLSNKVTLEKVLGIT--AEGNRALACE--------------------------PRTGLLAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLLNPRKNK-QHHIFNSSRKAITTLAFSPDGKYVVTGE---SGHMPAVRVWDVSERLQ---------------VSELQEHKYGVACVAFSPNGKYIISVGYEHDMMVNVWNWKKNVVVAANKVSSK-----VTAVSFSDDSSYFVTAG--NRHVKFWYLDHNKTSK--VNATVPLLGRSGLLGELRNNFFSDVACGRGRRSSSTFCITSSGLLCEFNERR-----------------LLDKWVELRVS-DRSETSQATCLSVTEEFIFCG-------CSDGTVRAFSPVNLHFLCTLP-------RPHSLGADIASMVDA--SQLFSCGADARYPDSVAVTYDPTNHWLSCVYNDHSVYVWDVRDLQDLRRAGKLYSALYHSSCVWSLEVSTGGTGE------------GERLLPPGSFLSCSSDNTIRLWNMDGHS---------------------ALHRN--------------------------------------------ILSHDL----------------------------------------KKVIYVEDN---VSSLPDADSITVAGG-------NAEKAGPPEGQQTDQIRTGIRALRVSPDGRHLASGDRMG-VLRIHDLDSMEEILNVQAHDSEILCLEFS--------KPD-TGLQLLATASRDRLIHILDAG--RDYSLVQTLDEHSSSITAVRFAANEGKVRMISCGADKSVYFRSAQ---QTEEG-LEFIRTHHVVRKTTLYDMDVEPTRKYAAVGCQDRNI--RIFNVSNAKQKKAYKGSQGEDGT-IIKVHID-----------PSGLYIAT---SCSDKNISIFDFFSGECVATMFGHSEIITG---------LKFSG-------DCKHLITVS-----------GDS--CIFVWRLSPEMTIRMRQRLADLKPRRS-V------------------PHRQNAPQQR-----AVKVSRT-----PPPCVDMMSSDSNGEEEEEEEQPRPYMETAGCVKEADFLAMLG---------------------------------------------------------------------------HVTDLRLLVCFPQRCSAETTG--RTPQEDSTA---------QLPRRRWSRRTS-SA----DSVLMVKSMFDLRMLDSASPDIHGDQEEGKTRPHPDFG-----LKRRTP-------------------AVEPKLHRASEDLQSTTSLQVASAWVRHLQASESEDSSQQEVGTQEKNPKDSGRYFREKFETPPPV-------------SEFQVKEAC-------PTEGGQQEKPSPDSGCSLGFSSALSSPERPA-GDDTEPTEPLSEDGNSSELEMEEEEVVGRQRR-----EGAGGSQNVPQTPD--QEAFLKEN------------------------------------------------------------------FVTLADPSASGSPSRTSNSSS---------------ESLSISSRFLHQSS--AARRNDG---KALGNQNQDQPQTQKDQPPLVQVQNPNQQGPDLPQQQQGAPEE-TSSGHPCFRSA------TSKK-KVQTEVEPRRNMVLP-------------------------------------------------------------TPSHQNPGLHKA---------QSVNSLLADAGETSSFR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSSPGE----------LSD------------------------------------------------------------------------------------------------PESAAVTLRKSSSSSAAVA-----APRSYMSPTASSMAKIAKE------------------------------------------------------------------------------------------------------------------------------APPTNVAVGNSAALP-----------------------------------------------------------ATPPHAAV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVVVSPSSSAAGNHGNRAGPPPRSL-----------------------------------------------------QARVSGSSKP-LPDKPSLDVFSPPTK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Tetraodon nigroviridis_MAPKBP1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVVSFLQNLFVVVSSNKVSSK-----VTFGSFSEDSSYF---G--NRHVKFWYLDHSKASK--PAPRSLCSPGQGCWGELRNNFFCDFACGRGSTSGSTFCITSSGLLCEINSKR-----------------MLDKWVDL-------QTSAAHSLSLSEDTIFCG-------CADGAVHVFKAVDLQFACTLP-------RPHSLGSDAAAVTET--SPFFSTKTGTRYPDAIAMTFDPVNHWLSCGYNDHSLYVWDIR---DVNRVGKVHAALYHASCVWDLEMFPELPDE------------VGSGLSSGVFLSCSADNTIRVWRMDEWT----------------------RSQN--------------------------------------------LLSTDL----------------------------------------QNIIYIDGS---ATALLDPESLANI---------NPEKPGD---AQMAETRTGIRTICLSPDGKHLASGDRNG-ILRVHSLSSMEEILKVDAHDAEILCLEYS--------KPE-TGLKLLATASRDRLIHVLDAN--NDYGLVQTLDEHSSSITAVRFAACENNVRMISCGADKSIYFRTAH---KTDRG-TEFRRSHHMVRKTTLYDMGVDPTCKYAAVGCQDRCI--RIFNINSGKQKKLYKGSLSEDGS-LIRVQLD-----------PSGQYVAT---SCSDKNISIFEFNTGECVATMLN--EIVTG---------MKFTN-------DCKYLISAS-----------GDS--CIFVWRLAPELTIRMRERLWRLRRGPDPP------------------AGATSALR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Gasterosteus aculeatus_MAPKBP1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPPQSHPNDPPSSPPHRMAGDG-ATIKSRIRNLLLRSPSAKQRK------SRESLGRQVTLEKVLGIT--ASGNSGLTCD--------------------------PRSGLVAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLLNPKKKR-QHHIINTSRKTITSLSFSPDGKYLVTGE---SGHLPAVRLWDVEERRQ---------------VAELHEHKYGVSCVAFSPNSKFIVSVGNQHDMMVTVWVWKKDVVVAANKVSSK-----VTGVSFSEDSSYFVTAG--NRHVKFWYLDHCLASK--ASAPVPLLGRSGLLGELRNNFFCDVACGRGSTSDSTFCITSSGLLCEFNGER-----------------MLDKWVDLRRRVDLVQTSAAQSLSLSEDTIFCG-------CADGTVRAFSSADLHFACTLP-------RPHPLGTDVAAVTEP--GHLFSAKACGRYPDVVAVTFDPVSQWLSCVYDDHSLYVWDVS---DVNRVGKVHSALFHAASVGDLEMFPDVPGE--------------SGLSTGAFLSCSADNTIRLWRSDDRTR-----------------A-PFRSRN--------------------------------------------ILSSDL----------------------------------------LNIIYVDGN---TGALQDPECWTNM---------NADKQGD---GQTAESRTGIRTICVSPDGRHLASGDRSG-TLRVHDLRSLAEILKVESHDAEILCLQFS--------KPE-TGVKLLATAGRDRLIHVLDAE--DDYALLQTLDEHSATVTAVRFAATDNKVRLISCGADKSIYFRTAL---KTERG-TEFRRSHHMVRKSTPCDMDVDPTCKYAAVGCQDRCINCRVFNISSGKQKKIYKGSLSEDGS-LLKVTVASIISPRRFSLITSGQYVAT---SCSDKNISIL-FHTGECVATMDGHSEIVTG---------MKFTN-------DCQHLISVS-----------GDS--CIFVWRLAPELTARMSERLSELLQHPNAP------------------PCRAAGLRWR-----SEGVSRREAHDAPTPGGPSSDSDLEREEDGAEDDDPEDAAADASSDSSSSSRGEE---------------------------------------------------------------------------DAVQVLTMWEFKTRSHRASVT----QDPPDSS---------KRPRRRWSHRMA-------PLELMVKSMLDLRQLETFAPKKRPRERQSTSSLQEAA-------RASGG-------------------ATTETCCTPRRASATRVSRAGKSPAQRTCFHSGNKRAFLFSVSVRPRPSLSPHPLSHFSYASDYTV-------------KEQRCRTR--------ASRRESKESRSPDSARSLGYGSRDSSPERPPRAHDCADVESLSPGSSDEEPDEGEEDERGAEVT-----SLDRALRTVTETADDGEEDFLKHN------------------------------------------------------------------FETPNESCSTGPPMQTTLIG----------------LSVSLSSSLLFATASYFPPCFSSPALDVCPQPSRAAKAPGKEPCSRSAKPPVSKVRPLMEDNRSGNPADRVPVSPGRVEGP------KNKCPLVCSSPALHSPVTSSDRRE-------------------------------------------------------PRRRPQQLSLFHDAP--------HPSFHFSSPSNGSSQSP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSPLPWESPKLRPHSYMNP------------------------------------------------------------------------------------------------TASSMAKSSRSTSLGDVIQ-----PGSPPCSPLFHRGRRSSVE------------------------------------------------------------------------------------------------------------------------------PEVEPPSLSSRPALSSPPRT------------------------------------------------PPRPPAAVSPSPNR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPSRIPLPKQQLSPRRSLCLEEMASS-----------------------------------------------------QVRLPCSTCPSLPSPPSVTGPSPSVIKRVSLGP---PTRRTWVSPQSLQGLSLSLSLPAD-----PSITLETCRQAVTELRNSLKKTAMFYS-TVLQSDRRLGEDQQEMRSILSEALVAVKAELDSLPHP-----------------------------------ARVDPG----------VKGEGENTRALLEQYAELLLRSVERRLESKT--------- >Denio rerio_MAPKBP1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTVEN-TTIKSRIKN-LLRSPSIKLRR-SKAGNNKENLSNKVTLEKVLGIT--SAGSRALACD--------------------------PHSGLIAYPAGCVV--------------------------------------------------------------------------------------------------------------------------------------VLLNPKKNK-QHHIINSSRKTITTVSFSPDGKYVVTGE---SGHMPAVRVWDVAERTQ---------------VAELQEHKYGVACVSFSPNSKYIVSVGYQHDMIVNVWAWKKNVVVAANKVSSK-----VTAVSFSDDSSYFVTAG--NRHVKFWYLDHTKSSK--VNATVPLSGRSGLLGELRNNFFSDVACGKGRKASSTFCITTSGLLCEFNDKR-----------------MLDKWVELRT-------SMATSLSVCEDLIFCG-------CADGTVRAFTPTDLHFICTLP-------HPHSLGTDIATLTEA--SHLFSYKQNVRYPDAVAVSYDPSSRWLSCVYNDHSLYVWDVR---DLRKVGKVYSALYHSSCVWSVEVYPESRDG------------EQPRLSPGSFLSCSSDNTIRLWHTDAQNT--------------------SLSRN--------------------------------------------VISNDL----------------------------------------QKIIYMDSN---TSTLLDTDCTISS---------NSEKVDP----QTSENRTGIRTMCVSPDGLHLASGDRNG-TLRIHDLESMEEILDVQAHDSEILCLEYS--------KPE-TGLKLLATASRDRLIHILDAD--KEYSLLQTLDEHSSSITAVRFAANEGKVRMISCGADKSIYFRTAQ---KTEEG-TAFTRTHHIVRKTTLYDMDIDPTRKYAVIGCQDRSI--RIFNIGNGKQKKVYKGSQGEDGT-VIKVQTD-----------PSGLYVAT---SCSDKNISIFDFYTGECVATMFGHSEVVTG---------MKFTN-------DCRHLITVS-----------GDS--CIFVWRLSPELTINMRQRLSDLK-QNS-R------------------PVQKTPPNKQ-----HTLSARKEIH--SAPVIGTMSSDSDKDVEEEEGIEEEDEMFPHLSSGS--SAGED---------------------------------------------------------------------------TGSSEEKHNSLNSHMKKQSSS----SEHESSG---------SRPRRRWSRRMG-SI----D--LKVKSMLDLRQLESFAMPLFPS-------------------KSHDA-------------------PKNPPAPK-NQDLGSTISLQTLAAWMP---------------------------------------------------------------------EENGQ--------------------------------TRP-------------------------------HYIQLPPQTPE--TEVLYPEG------------------------------------------------------------------CEDQSSLAGRWVSLGTNLHYL---------------KALSTQITFE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Homo Sapiens_WDR16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAVVLPWQIFGVRELPVERGVT--MKGPRLFRAPGHVPTGLKCH----------------PDQEHMIYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------LIQAINTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRE---------------LLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAG--NGTIRVWELDL---------PNRKIWPTECQTGQLKRIVMS---IGVDDDDSFFYLGTTTGDILKMNPRT----------------KLLTDVGP---------AKDKFSLGVSAIRCLKM----------GGLLVGSGAGLLVFCK--------------SPGYKPI-----------KKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTD------FKETLIATCHFDAVEDIVFP----------------------FGTAELFATCAKKDIRVWHTSSN---------------------------------------------------------------------------------------------------------------------RELLRITVP-----------------------------------------NMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATT------------SDCKRVISGGGEGEVRVWQIG-CQTQKLEEALKEHKSSVSCIRVKR-NNEECVTASTDGTCIIWDLVR-----------LRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIA--YWEVFDGTVIRELEGSLSGSIN---GMDIT-----------QEGVHFVT---GGNDHLVKVWDYNEGEVTHVGVGHSGNITRI---------RISP-------GNQYIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKYPYTS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Gorilla gorilla_WDR16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAVVLPWQIFGVRELPVERGVT--MKAPRLFRAP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAG--NGTIRVWELDL---------PNRKIWPTECQTGQLKRIVMS---IGVDDDDSFFYLGTTTGDILKMNPRT----------------KLLTDAGP---------AKDKFSLGVSAIRCLKM----------GGLLVGSGAGLLVFCK--------------SPGYKPI-----------KKIQLQGRITSITLRGEGHQFLVGTEESHIYRVSFTD------FKETLIATCHFDAVEDIVFP----------------------FGTAELFATCSKKDIRVWHTSSN---------------------------------------------------------------------------------------------------------------------RELLRITVP-----------------------------------------NMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATT------------SDCKRVISGGGEGEVRVWQIG-CQTQKLEEALKEHKSSVSCIRVKR-NNEECVTASTDGTCIIWDLVR-----------LRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIA--YWEVFDGTVIRELEGSLSGSIN---GMDIT-----------QEGVHFVT---GGNDHLVKVWDYNECEVTHVGVGHSGNITRI---------RISP-------GNQYIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKYPYTS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Pongo abelli_WDR16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDNKISPEAQVAELELDAVIGFN--GHVPTGLKCHP--------------------------DQEHVIYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------LIQAINTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWGYKKRE---------------LLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFVTAG--NGTIRVWELDL---------PNRKIWPTECQTGQMKRIVMS---IGMDDDDSFFYLGTTTGDILKMNPRT----------------KLLTDAGP---------VKDKFSLGVSAIRCLKM----------GGLLVGSGAGLLVFCK--------------SPSYKPI-----------KKIQLQGSITSITLRGEGHQFFVGTEESHIFQVSFTD------FKETLIATCHFDAVEDIVFP----------------------FGTAELFATCAKKDIRVWHTSSN---------------------------------------------------------------------------------------------------------------------RELLRITVP-----------------------------------------NMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINSAHRIGVTAIATT------------SDCKRVISGGGEGEVRVWQIG-CQTQKLEEALKEHKSSVSCIRVKR-NNEECVTASTDGTCIIWDLVR-----------LRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIA--YWEVFDGTVIRELEGSLSGSIN---GMDIT-----------QEGVHFVT---GGNDHLVKVWDYNEGEVTHVGVGHSGNITRI---------RISP-------GNQYIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKYPYTS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Equus caballus_WDR16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESQISPKAEVAELELEAVIGFN--GHVPSGLKCHP--------------------------DQEHVVYPLGCTI----------------------------------------------------------------------------------------------------------------------------------------LIQAVNTHEQNFLHGHDNNVSCLTISKSGIYIASGQVTFMGFKADIILWDYKKRE---------------LIARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATTVIFSRCRDEMFVTAG--NGTIRVWELDL---------PNRKIWPTECLTGQMKRIVMS---LTMADDDSFFYLGTTTGDILKMNPRT----------------KLLADTGP---------AKDKFSLGVSAIKCLKM----------GGLLVGSGAGLLVFCK--------------SPSYKPI-----------KKIQLQGGITSIALRGEGHQFFVGTEESHIYRVTFTD------FKETLIATCHCEAVQDIVFP----------------------FGTAELFATCAKKDIRVWHTLSN---------------------------------------------------------------------------------------------------------------------RELLRITVP-----------------------------------------NMTCHGIDFMRDGKSIISAWDDGKIRAFAPETGRLMYVINNAHRIGVTAIATT------------SDCKRIISGGGEGEVRVWQIG-CQTQKLEEALKEHKSSVSCIRVKK-NNEECVTASTDGTCIIWDLVR-----------LRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIA--YWEVFDGTVIRELEGSLSGSIN---GMDIT-----------LEGVYFVT---GGNDHLVKVWDYNEGEVTHVGVGHSGNITRV---------RISP-------GNQYIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKYPSAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Loxdonta africana_WDR16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDTQTSPEAEVAELELEAVIGFN--GHVPNGLKCHP--------------------------DQEHLIYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------LIQSINTNEQNFLHGHGNNVSCVAVSKSGVYLASGQVTFMGFKADIILWDYKKRE---------------LVARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIARRDAICGSPAAGLNVGNATTVIFSHCQDEMFVTAG--NGTIRVWELDL---------PNRKIWPTECQTGQMKRIVMS---ITMADDDSFFYLGTTTGDIFKMNPRT----------------KLLTDTGP---------LKDKFSLGVSAVKCLKM----------GGLLLGSGAGLLVFCK--------------SPSYKVI-----------KKIQLQGGITSITLRGEGHQFFVGTEESHIYRINFTD------FKETLIATCHCEAVQDIVFP----------------------FGTAELFATCAKKDIRVWHTLSN---------------------------------------------------------------------------------------------------------------------RELLRITVP-----------------------------------------NMTCHGIDFMRDGKSIVSAWDDGK-RAFAPETGRLMYVINSSHRIGVTAIATT------------SDCKRVISGGGEGEVRVWQIG-CQTQKLEEALKEHKSSVSCIRVKK-NNEECVTASTDGTCIIWDLVR-----------LRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIA--YWEVFDGSVIRELEGSLSGSIN---GMDIT-----------VEGVHFVT---GGNDHLVKVWDYNEGEVTHVGVGHSGNITRI---------RISP-------GNQYIVSVS-----------GDG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKYPYAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Mus musculus_WDR16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEEQVLPELDVAELELQAVIGFN--GHVPNGLKCHP--------------------------DQEHLIYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------LIQAINTNEQNFLHGHGNNVSCVTISKEGDYIASGQVTFMGFKADIILWDFKKRE---------------LIARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATSVVFSRCRDEMFVTAG--NGTIRVWELDL---------PNRKIWPTECQTGQMKRIVLS---TGMADDDSFFYLGTTTGDILKMNPKT----------------KLLADTGP---------VKDKFSLGVSALRCLKM----------GGLLVGSGAGLLIFCK--------------SPSYKPI-----------KKVQLQGGITSITLRGEGHQFFVGTEESHIYRVNFTD------FKETLIATCHFEAVQDIVFP----------------------FGTAELFATCAKKDIRVWHTMSK---------------------------------------------------------------------------------------------------------------------RELLRITVP-----------------------------------------NMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSAHRIGVTAIATT------------SDCKRIISGGGEGEVRVWQVG-CQTQKLEEALKEHKSSVSCIRVKK-NNEECVTASTDGTCIIWDLVR-----------LRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIA--YWEVFDGSVIRELEGSLSGSIN---GMDIT-----------QEGGHFVT---GGHDHLVKVWDYNEGEVTHVGVGHSGNIMAM---------RISP-------GNQYIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKYPFAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Rattus norvegicus_WDR16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEEQILPETDVAELELQAVIGFN--GHVPNGLKCHP--------------------------DQEHLVYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------LIQAINTNEQNFLHGHGNNVSCVTISKEGDYVASGQVTFMGFKADIILWDFKKRE---------------LIARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATSVVFSRCRDEMFVTAG--NGTIRVWELDL---------PNRKIWPTECQTGQMKRIVMS---SGMADDDSFFYLGTTTGDILKINPKT----------------KLLADTGP---------MKDKFSLGVSALRCLKM----------GGLLVGSGAGLLIFCK--------------SPSYKPI-----------KKLQLQGGITSITLRGEGHQFFVGTEESHIYRVNFTD------FKETLIATCHFEAVQDIVFP----------------------FGTAELFATCAKKDIRVWHTMSK---------------------------------------------------------------------------------------------------------------------RELLRITVP-----------------------------------------NMTCHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSAHRIGVTAIATT------------SDCKRIISGGGEGEVRVWQIG-CQTQKLEEALKEHKSSVSCIRVKK-NNEECVTASTDGTCIIWDLVR-----------LRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIA--YWEVFDGSVIRELEGSLSGSVN---GMDIT-----------QEGEHFVT---GGHDHLIKVWDYNEGEVTHVGVGHSGNIMGI---------RISP-------GNQYIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKYPFAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Monodelphis domestica_WDR16 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADADTLPEPEVLGLELQAVIGFN--GHVPSGLICHP--------------------------DQEHLVYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------LIESINTKKQYFLHGHGNNVSCVTISLNGAYVASGQVTFMGFKADVILWDYAKKE---------------LIARLSLHKGKIEALAFSPNSKYLVSLGGPDDGSVVVWSVTKRDAICGSPAAGFNVGNATTIIYSNCREEMFVTAG--NGTIRVWELDL---------PNRKIRPTECQTRQLKRVVLS---IAMAEDDSFFYIGTTTGDILKLNPRT----------------KLLADTGP---------VKDKFSGGVTTIKCLKM----------GSVLIGSGAGVVALCK--------------SPSYKPI-----------KKIQLQGGVTSVALRGQGHQFFVGTEAAHIYCLSYTD------FKAELIATCHSGAVQDIVFP----------------------FGTADLFATCSKEDIRVWHTSSN---------------------------------------------------------------------------------------------------------------------RELLRITVP-----------------------------------------NMTCCAIDFMRDGKSIISAWNDGKIRAFTPETGRLMYVINNAHSIGVTAIATT------------SDCRRIISGGGEGQVRVWEIS-PQSQKLEEALKEHKSSVSCIKVKK-NNEECVTASTDGTCIIWDLVR-----------LKRNQMILANTLFQCVCYHPEEFQIITSGTDRKIG--YWEVFDGTVIRELEGSLSGSIN---GMDIS-----------SEGVHFVT---GGDDHLVKVWNYSDGEVTHVGVGHSGNIIRM---------KISP-------NNEHIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKCPFTS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Gallus gallus_WDR16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATATPEERAAGGLELQAAIGFN--GHVASGLICHP--------------------------DNKHLLYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------VIQDLASKKQTFLHGHTNNVSCVVVSRSGNYVASGQVTFMGFKADIILWDFQKKE---------------LLARLSLHKGKIEGLAFSPNDLYLVSLGGRDDGSVVVWNVSKREAVCGSPASARSAGNVTIVECSACRDEMFVTAG--SETIRVWELDL---------PNRKLRPTECQTGQLRRVITS---LQIADDDNYFYVGTSTGDVLKVNTRN----------------KLMTDFGP---------QK-KFSLGVTALLLLKT----------GDVIIGTGEGTVALCK--------------GSNYRVM-----------KNIQVHGGVTSLTRRGQGHQFFVGTKMCQIYRVNYTA------FKEELITTCHSEAVHDIVFP----------------------FGTSDLFATCSKDDIRVWHTPEH---------------------------------------------------------------------------------------------------------------------RELLRIVIP-----------------------------------------NMTCYAIEFMRDGKSIISAWNDGKIRAFMPESGREMYVINNAHSRGVTAIAAT------------SDCKRIVSGGGEGQVRVWAIG-EKTRKLEGVLKEHISAVSCIKIKK-NDKECVTASLDGTCIIWDIGR-----------FTRKQMILANTLFKCVCYHPEEYQLITSGTDRRIG--YWEVYDGSAIRDLEGSLSGSIN---GMDIT-----------SDGAYFVT---GGDDHLVKMWDYNEGTVTHIGVGHSGNITRL---------KICP-------GNKYIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILL------------------------------------------------------------------------------------------------------WKYPGCP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Anolis carolinensis_WDR16 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNEEAAPPEDLAG-LQLEAIIGFN--GHVPCGLICHP--------------------------DREHLIYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------IVQGINIRTQEFLHGHTNNVSCVTISASGSYVASGQITFMGFKADIILWDYNKKE---------------MWARLSLHKGKIENLAFSPNDLYLVSLGGQDDGSIVVWSIQKKEAICGSPASARSAPNPTSLVYSNCRDEMFISAG--SGTIRVWELDL---------PNRKIRPTECHTGQLKRIVTC---IMITDDDKYFCIGTSTGDIVKLNTKS----------------TLMSDYGP---------VKDKFSLGVTALLLLKT----------GDLVIGTGTGLIALCS--------------ASNYKVK-----------KKVQLQGAITSITPRGQGHQFFVGTEEAHIYRFSYSD------FKDELIATCHNEAIHDIIFP----------------------YGTSDLFATCSKSDIRVWYTPEN---------------------------------------------------------------------------------------------------------------------RELLRITIP-----------------------------------------NMTCHAIDFMRDGKSIISAWNDGKIRAFTPETGRLMYVIEHAHSMGVTAVAST------------SDCKRIISGGGEGQVRVWEIG-KETRTLEEVMKEHISSISCIKIKK-NNQECVTASIDGTCIIWDLVR-----------FMRRQMILANTLFKCVCYHPDEHQLITSGTDRKIA--YWEVFDGSPIRDLEGSLSGSIN---GMDIT-----------SDGAYFVT---GGDDHLVKVWDYNEGEVTFVGVGHSGNITRL---------KICP-------NNKYIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKYPHVH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Pelodiscus sinensis_WDR16 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGFKADIILWDYKKRE---------------LLARLSLHKGKVEKLAFSPNDLYLVSLGGQDDGSVVVWSIAKREAICGSPASARSAGNATVLAFSSCRDESFVSAG--NGTIRVWELDL---------PNRKIRPTECQTGQLKRVVTC---IMMAEDDSYFYVGTSSGDLLKLNMKS----------------KLMSDYGP---------VKEKFSLGVTALLLLKT----------GELVVSTGGGVVALCK--------------GSNYKPI-----------KKIQVQGGITSLTGRGQGHQFFVGTEESQIYRLNYNE------FKEELIATCHNEAIHDIIFP----------------------SETSDLFATCSKSDIRVWHTPEN---------------------------------------------------------------------------------------------------------------------KELLRITIP-----------------------------------------NMTCHAIDFMRDGRSIISAWNDGKIRAFTPETGRLLYVIDHAHSMGVTAIATT------------SDCKRIISGGGEGQVRVWEIG-QHTRKLEGVLKEHISTISCIKIKK-NNRECVTASTDGTCIVWDLVR-----------FMRNQMILANTLFQSVCYHPEEHQIITSGTDRKIG--YWEVFDGSAIRNLEGSLTGSIN---GMDIT-----------SDGTYFVT---GGDDHLVKVWDYNEGEVTHVGTGHSGSITRI---------KICP-------GNKYIVSVS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WKYPHSP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Xenopus tropicalis_WDR16 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRRTVMAEQGEDNRLELQGIIGFN--GHVPSGLISHP--------------------------DREHLIYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------IIENLSSRKQQFLQGHTNNVSCVAASRSGRYLASGQVTYMGFKADILLWDYGRRE---------------ACAKLTLHKVKVEALAFSPNDLYLVSLGGQDDGSVVVWNVAKREAICGSPASSLSSGHATTIIFTNNSDDIFMTGG--NGTLRVWDVDL---------PNRKMRPTECQLGQMKRVVTC---LQVAEDDSCFYCGTSSGDILTINTKS----------------KLLSSFAP---------QKGKFSLGVTALRLLKT----------GELLVGSGDGKLALCK--------------GPNYKAA-----------KTVQLQGSVTSISLRGQGHQFFVGTGGAQIYRFSYPE------FKEELIATCHSEAINDIAFP----------------------FGTSELFATCSKNDIRVWHTATH---------------------------------------------------------------------------------------------------------------------KELLRITVP-----------------------------------------NMTCLAIDFMRDGKSIISAWNDGRIRAFMPESGRLMYCIENAHSMGVTAIAAT------------SDCKRIVSGGGEGQVRIWEIS-KETQRLVQSMKEHKSSVTCIKLKG-NNRECLTASSDGTCIIWDIVR-----------FTRLQMVLSNTLFRCVCYHPEEFQFVTSGTDRKVG--YWEVFDGSAIRELEGSKSGAIN---GMDIC-----------DQGAHFVT---GGDDKLVKVWDYNEGEVTHVGIGHSGNITRL---------KICP-------LSKYIISVS-----------TDG-----------------------------------------------------------------------------------------------------AILC------------------------------------------------------------------------------------------------------WDYPYGLR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Latimeria chalumnae_WDR16 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPFPLLT--GQVPAGLIAHP--------------------------DRENILYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------IIQSLKNKKQSFLHGHTNNVCCLGVSRDGTYLASGQVTYMGFKADVIIWNYAQRE---------------LYARLSLHKAKVQSVAFSPNGLYLATLGGQDDGSLVIWNVAKKEAICGSPASAVSSGNALTVKFSNHSDEIFITAG--NTTIRVWELDL---------PNRKIRSSECQTGQLKRIVNC---IEISEDDAFFYCGTTTGDILKLGLKN----------------KLLSSYAP---------QKEKFGLGVTALALLKT----------GDFLVGSGDGFVALCK--------------PSTLKIV-----------KKAHLHGAVNSIALRGEGHQFFAGTGCAQIYRFNYVE------FKEELIAACHNEAVNDIAFP----------------------FGTSELFATCSKSDIRVWHTQSK---------------------------------------------------------------------------------------------------------------------KELLRITIP-----------------------------------------NMTCHGIDFMKDGKSIISGWNDGKIRAFTPESGRLMYVINNAHSIGVTAIAAI------------GSCKRIVSGGGEGMVRVWEIG-QGFNTLIESMKEHKASVSCIRVKS-NDQECVTASTDGTCIIWDIVR-----------FVRNQMVLANTLFRCVCYHPEGYQIITSGTDRKIA--YWEVFDGTPIRELEASVSGSVN---GMDIS-----------QDGKYFATEP-GGDEKLIKLWGYNEGEVTHVGIVHNDFIITVDPEDDDGGFKNNPPCGLGANSDKLAEEVP-----------ASGGETVTGKKSTTLTSQGSAKERLSSWCYYGDKT----------------------PGVQGLKNHGNTCFLNAVVQCLSNTDLFAEYLGLEQYKSDLNQGKLNGIVRSNSGELQGRGEVTEQLASLVRAL-------------------------------------------------------------------------------WTLEYTPQLSVEFKVSGPKKNLI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Takifugu rubripes_WDR16 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDADTHGLPPVELRAVFGFN--GSVRSGLSVHP--------------------------DGEHLIYPLGSTV----------------------------------------------------------------------------------------------------------------------------------------VLRTIKDGRQELLQGHTSDVSCVSVSRSGSLIASGQVDCMGFKAVIIIWDYPQRR---------------SSAQLLLHEAKVEALDFSPDEKYLVSLGGQDDGRVVVWNVETRQAVCGSAASGRSTSPCLTVRYSNTNSNLFVTAG--SSALRVWELDP---------LNRKIQPTECQTGILKRAVEC---IEISEDDEFVFCGTTSGDIMKFNLKT----------------RRLSDYGPK-------RFSAKHSRSVSALRTLKG----------GHLLVGSGCGKLMLCS--------------ASSFQAL-----------KEAQLEKAVTSIALSGEGQQFFVGTEAAQMYGFRSED------FRAELISSSHRSAVKDVAIC----------------------FGTSELFATCSEEDIRVWHIDKP---------------------------------------------------------------------------------------------------------------------KELLRITVP-----------------------------------------NMTCNALDFMSDGHSIISAWNDGKVRVFAPESGRLVLIIHDAHNTGVTAIAGT------------RNCKRIISGGGKGMVRVWELQ-PKGHRLLETMKEHRGAVTCIKIKS-DDKECVSASSDGACIIWDLVR-----------FVSLKMVITTRLFRAVCYHPDIYQIITSGTDRKVV--YWDAYDGSAIRELEGLLTGSIN---AMDIS-----------QSGTHFVTATSGGDDKLVKVWDYMEGAVTHVGMAHGGSITGI---------KLCS-------NSSTLISTS-----------ADG-----------------------------------------------------------------------------------------------------AVVL------------------------------------------------------------------------------------------------------WRFPHSPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Tetraodon nigroviridis_WDR16 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQADAHGVASVELRSVFGFNDPGRVCSGLRLHP--------------------------DRERLLYPLGSAL----------------------------------------------------------------------------------------------------------------------------------------ILRTIKDGQQELLQGHTNDVSCLSVSRSGSYVASGQVDCVGFKAAIIIWDYAQRG---------------IYAQLLLHEAKVEAVDFSPDEKYLVSLGGQDDGRVVVWNVASRQAICGSPASGRSSSSCLTVQFCNTNSNLFVTAG--SSALRVWELDP---------QNKKMEPTECRTGILKRVVTC---IEISEDDQFLFCGTTSGDILKINLRT----------------RLLSDYGPK-------RSSAKHGRSVSALRMLRS----------GHLLVGSGCGKLMLCS--------------ATGFQAL-----------KEAQLEKAVTSIALSGEDQRFFVGTEAAQMYSISCQD------FRPELVSSSHRSGVKDVAIC----------------------FGTSELFATCSEEDIRLWHIDKP---------------------------------------------------------------------------------------------------------------------KELLRITVP-----------------------------------------NMTCNALDFMTDGHSIISAWDDGKIRVFAPESGRLMLIIHGAHNMGVTAIAGT------------RNCKRIISGGGTGMVRVWELQ-SKGHRLLETMKEHKGTVTCVKIKG-DDKECVSASSDGVCIIWDIVR-----------FVSLKMVITNRLFRAVCYHPDIYQIITSGTDRKVV--YWDAYDGSAIRELEGLLAGSIT---AMDIS-----------PSGSHFVT---GGDDNLVRVWDYMEGVVTHVGTAHGGSITSI---------KLCS-------NSSTLISTS-----------ADG-----------------------------------------------------------------------------------------------------AIVL------------------------------------------------------------------------------------------------------WRFPHSPT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Gasterosteus aculeatus_WDR16 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDETMSLETHGVPQLELEAVIGFN--GYVSSGLRVDP--------------------------DSEHLIYPLGCSV----------------------------------------------------------------------------------------------------------------------------------------ILKRIKGGKQESLHGHSNNVSCVSVSKSGSYIASGEVTFLGFKAVIIIWDYAQRS---------------IYAKLQLHKAKIEALAFSPNDKYLVSLGGQDDGRIVVWNIETKQAICGSAASPGMAGDCLTVQYSNTDDNVFVSAG--SGTLRVWELDR---------ANCRIQPTECQTGRLKRIVKC---VQISEDDQFIFCGTTSGDIMEINLKM----------------GRLTNCGP---------TEGKYSMGVNVLRILQC----------GDLLVGSGSGILTLCS--------------GTNFKTLNFSQ------NKKVPLEKGVTSLAIGGEGKQFLVGTEAAQMYRFGCD-------FRKELISTSHNSAVKDGLIC----------------------FGTSELFATCS-DDIRLWHRDN-----------------------------------------------------------------------------------------------------------------------ERLRIIVP-----------------------------------------NMTCNSLDIMLDGHSIISGWNDGKIRVFAPESGRLMLIIHDAHQRGVTAIAGT------------RDCKRIVSGGGDGQVRIWELL-PHGHRLVETMKAHTATINCIKIKS-DSKQCVTASADGACIIWDLVR-----------FLSLQMVMTNTRLRDVCYHPEEYQIITSGSDRKVA--YWDVFDGTLIRELEGSKFGSIN---GMHIS-----------QDGKHFVT---GGDDKLVKVWDYMAGTVTHVGIAHGASITRV---------KICS-------NNRTIISTS-----------ADG-----------------------------------------------------------------------------------------------------AILR------------------------------------------------------------------------------------------------------WRFPHPSPS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Oryzias latipes_WDR16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAESQFPKINIPQLELEAVIGFN--GRVPSGLRLHP--------------------------DKQHLIYPLGCTV----------------------------------------------------------------------------------------------------------------------------------------ILRSISDDKQEFLHGHTNNVCCLSVSRSGTYIASGQINFLGFKTTVFIWDYAQRS---------------VYAELVLHKAKVESLAFSPNDKYLVSLGGQDDDSIVVWNIETKQAICGSTATSHVARHCLVVQYSNTDDNVFVSAGRGSGTLRVWELDV---------ANRKIRPTECKLGKLQRNIKC---VEISNDDQFLFCGTTSGDILKVNLRT----------------GLLSDFGP---------VKAKHSLGVSVLRVMES----------GDLLVGSGSGVLTLCS--------------KTNFKML-----------QSIQLEKGVTSITIKDTGQQFFVGTEAGLIYRMSSDD------FKAEVVFTSHTSAVKDVVMP----------------------FGTSELFATCSDDDIRLWHIDKP---------------------------------------------------------------------------------------------------------------------KELLRIPVP-----------------------------------------NMTCNALDFMIDGHSLISAWNDCKIRAFGPETGRLMFTINDAHKMGVTAIAGT------------RDCKRIVSGGGDGQVRVWELL-PHCHRLVEIMKEHKATVSSLKIKS-NDKECVTASVDGTCIVWDLER-----------FVGLQRMIANTVFRAMCYHPEEHQIITSGTDRKLS--YSFLYDGSIIRELEGSQSGAIN---AMHIT-----------KDGGYFVT---GGDDRVVRVWSYMEGVVTHVGIAQGGSITSM---------KICS-------NNRILVTTS-----------ADG-----------------------------------------------------------------------------------------------------AIMQ------------------------------------------------------------------------------------------------------WKFPHPP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------