>Homo_sapiens_XKR4 -------------MAAKSDGRLKMKKSSDVAFTPLQNSDHSGSVQGLAPGLPSGSGAEDEEAAGGGCCPDGGGCS-RCCC CCAGSGGSAG----SGGSGGVAGPGGGGAG-SAALCLRLGREQRRYSLWDCLWILAAVAVYFADVGTDVWLAVDYYLRGQ ------RWWFGLTLFFVVLGSLSVQVF-SFRWFVHDFSTEDSATAAAASS-CPQPGADCKTVVGGGSAAGEGEARPSTPQ RQASNASKSNIAAANSGS----------------------------NSSGATRASGKHRSASCSFCIWL-LQSLIHILQL GQIWRYFHTIYLGIRSRQSGE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------NDRWRFYWKMVY-EYADVSML HLLATFLESA---PQLVLQLCIIVQTHSLQA-LQG-----------------------FTAAASLVSLAWALASYQKALR DSRDDK----KPISYMAVIIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETE FCITK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALSA---LWYLYKA----- -------PQIADAFAIPALCVVFSSFLTG----VVFMLMYYAFFHPNGPRFG---------------------------- -------------------------------------QSPS--CACEDPA----------AAF-TLPPDVATSTLRSISN NRSVVSDRD----QKFAERDGCVPVFQVRPTAPSTPS------SRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAIL AFE-CSPSPPRLQYKD-DALIQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Pan_troglodytes_XKR4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----RYFHTIYLGIRSRQSGE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------NDRWRFYWKMVY-EYADVSML HLLATFLESA---PQLVLQLCIIVQTHSLQA-LQG-----------------------FTAAASLVSLAWALASYQKALR DSRDDK----KPISYMAVIIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETE FCITK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALSA---LWYLYKA----- -------PQIADAFAIPALCVVFSSFLTG----VVFMLMYYAFFHPNGPRFG---------------------------- -------------------------------------QSPS--CACEDPA----------AAF-PLPPDVATSTLRSISN NRSVVSDRD----QKFAERDGCVPVFQVRPTAPSTPS------SRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAIL AFE-CSPSPPRLQYKD-DALIQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Mus_musculus_XKR4 -------------MAAKSDGRLKMKKSSDVAFTPLQNSDNSGSVQGLAPGLPSGSGAEDTEAAGGGCCPDGGGCS-RCCC CCAGSGGSAG-------SGGSGGGGRGSGAGSAALCLRLGREQRRYSLWDCLWILAAVAVYFADVGTDIWLAVDYYLRGQ ------RWWFGLTLFFVVLGSLSVQVF-SFRWFVHDFSTEDSS--TTTTSSCQQPGADCKTVVSSGSAAGEGEVRPSTPQ RQASNASKSNIAATNSGS----------------------------NSNGATRTSGKHRSASCSFCIWL-LQSLIHILQL GQIWRYLHTIYLGIRSRQSGE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------SGRWRFYWKMVY-EYADVSML HLLATFLESA---PQLVLQLCIIVQTHSLQA-LQG-----------------------FTAAASLVSLAWALASYQKALR DSRDDK----KPISYMAVIIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETE FCITK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALSA---LWYLYKA----- -------PQIADAFAIPALCVVFSSFLTG----VVFMLMYYAFFHPNGPRFG---------------------------- -------------------------------------QSPS--CACDDPA----------TAF-SLPPEVATSTLRSISN NRSVASDRD----QKFAERDGCVPVFQVRPTAPPTPS------SRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAIL AFE-CSPSPPRLQYKD-DALIQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Canis_familiaris_XKR4 ----------------------------------------------------------------------------CCAG SAGSGGGSAGGSGGGSGVSGGPGAPDGGGAGSAALCMRLGRERRRYSLWDCLWILAAVAVYFADVGTDIWLAVDYYLRGQ ------RWWFGLTLFFVVLGSLSVQVF-SFRWFVHDFSTEDSAPAAAASS-CPQPGADCKTAAGGGSAAAEGEARPSTPQ RQASNASKSNIAAANSGS----------------------------NSSGSTNIMKKVRSSSCSFCKILYSLISILSYSP CFLSRYFHTIYLGIRSRQSGE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------NDRWRFYWKMVY-EYADVSML HLLATFLESA---PQLVLQLCIIVQTHRLQA-LQG-----------------------FTAAASLVSLAWALASYQKALR DSRDDK----KPISYMAVVIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETE FCITK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALSA---LWYLYKA----- -------PPFADAFAIPALCVVFSSFLTG----VVFMLMYYAFFHPNGPRFG---------------------------- -------------------------------------QSPS--CACEDPV----------AAF-TLPPEVATSTLRSISN NRSVASDRD----QKFVERDGCVPVFQVRPTAPSTPS------SRLPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAIL AFE-CSPSPPRLQYKD-DALIQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Myotis_lucifugus_XKR4 -------------MAAKSDGRLKMKKSSDVAFTPLQNSDHSGSVQGLAPGLPSGSGAEDEEAAGGGCCPDGGGCS-HCCC CCSGSGGSGGGSGGSGGPGGSVGGPGGG-ASSAALCLRLGGEQRRYSLWDCLWILAAVAVYFADVGTDIWLAVDYYLRGQ ------RWWFGLTLFFVVLGSLSVQVF-SFRWFVHDFSTEDSATAAAAASSCSQPGADCKTLVRSGSAAAEGEVRPSTPQ RQASNASKSNIAAPNTGS----------------------------NSS---GASGKHRSASCSFCIWL-LQSLIHILQL GQIWRYFHTIYLGIRSRQSGE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------NDRWRFYWKMVY-EYADVSML HLLATFLESA---PQLVLQLCIIVQTHSLQA-LQG-----------------------FTAAASLVSLAWALASYQKALR DSRDDK----KPISYMAVVIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETE FCITK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALSA---LWYLYKA----- -------PQIADAFAIPALCVVFSSFLTG----VVFMLMYYAFFHPNGPRFG---------------------------- -------------------------------------QSPS--CACEDPV----------AAF-TLPPEVATSTLRSISN NRSVVSDRD----QKFAERDGCVPVFQVRPTAPSTPS------SRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAIL AFE-CSPSPPRLQYKD-DALIQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Anolis_carolinensis_XKR4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------IFPQ KSFFRYFHTIYLGIRSRRSGD----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------NDRWRFYWKMVY-EYADVSML HLLATFLESA---PQLVLQLCIVVQTRTLQA-LQG-----------------------LTAAASLVSLAWALASYQKALR DSRDDK----KPISYMAVIIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETE FCITK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALSA---LWYLYKA----- -------PMISDAFAIPALCVVFSSFLTG----IVFMLMYYAFFHPNGPRFG---------------------------- -------------------------------------QSPS--CACEDSV----------AAF-TLPPEVASSTLRSISN NRSVTSDRD----QKFAERDGCVPVFQVRPTAPSTPS------SRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAIL AFE-CSPAPPRLQYKD-DALIQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Xenopus_tropicalis_XKR4 -------------MAAKSDGMLKMKK-SDVAFTPLQNSDHSGSVQGLATGSQPGSATGD------------GGCSDGSSR CCCSGGSSSG---------RVAGGGGGVGGASPSLCLRLGREQQRYSVWDCLWILAAVAVYFADVGSDIWLSVDYYLRGQ ------RWWFGLTLFFVVLGSLSVQVF-SFRWFVHDFSTENSSQCNPMES----------KAAAGSAAACEGDARPSTPQ RQASTAS--------SKP----------------------------ATTGTNRANSRDSSSSCSFCIWI-MQSLIHILQL GQIWRYFHLNRLGFRERASGE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------XERWSFTFNYIHEEFTDRLVL HTLYIYLYTQ---PQLILQVCHKVKVYHITCNIAG-----------------------LTAAASLVSLAWALASYQKALR DSRDDK----KPISYMAVIIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETE FCITK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILLENTALST---LWYLNKA----- -------PQILDAFAIPALCVVFSSFLTG----IVFMLMYYAFFHPNGPRFG---------------------------- -------------------------------------QSPS--CACEDTV----------TAF-PLPPEGASNTLRSMSN NRSVASDRD----QKFTERDGCMPVFQVRPIAPSTPS------SRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAIL AFE-CSPSPPRLQYKD-DALIQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Takifugu_rubripes_XKR4_a --------------MAAKSDGVLKMKKSDVAFTPLQNSEHSGSVQGLH-------------------------------- ----PGAQLDSAGTGDADFANGESRCCGGGGSNSTCLRLGREQQKYTVWDCLWILAAVAVYVADVGSDVWLSVDYYLHND ------YWWFGLTLFFVVLGSFSVQLF-SFRWFVHDFSTEDGAVSAADCT-------HMDGNKLLSGSASHGDVTAQQHP ATPQRQASTASKNTTTNS----------------------------TASTAVG-RSEKRSAYYTFCVWI-SQSIIHILQL GQIWRYIHTIYLGIQSHQSVE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------TERWRYYWRMVY-EFADVSML HLLATFLESA---PQLVLQLCIIIQTHKLQA-VQEN--------------------AGMTAAASLVSLAWALASYQKALR DSRDDK----KPISYLAVIIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETD FCISK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYLLILVENAALSA---LWYLYRS----- -------PLATDAFAVPALCVIFSSFFTG----VVFMLMYYAFFHPNGPRFG---------------------------- -------------------------------------RSLSGHGLNLDPT----------AQFSTLPSEVATNSLRSNRG A-TATLERD---MGKYSERDGCMPVFQVRPTVPSTPS------SRAPRPEETVIKIDLCRNRYPAWERHVLDRSIRKAIL AVD-SSQTPPRLQYKD-DALVQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Tetraodon_nigroviridis_XKR4_a -------------------------------------------------------------------------------- ----------------------------GGGSHSTCLRLSREQQKYTVWDCLWIVAAVAVYVADVGSDVWLSVDYYLEED ------YWWFGLTLFFVVLGSFSVQLF-SFRWFVHDFSTEDSAEAAADGS-------HMDGNKLLSGSASH----HGQHR AGPQ---------------------------------------------------GPKRPAYYTFCVWG-SQSVIHILQL GQIWRYIHTIYLGVQSRQSAE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------TERWRYYWRMVY-EFADVSML HLLATFLESA---PQLVLQLCIIIQTHKLLA-VQG-----------------------MTAAASLVSLAWALASYQKALR DSRDDK----KPISYLAVIIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETD FCISK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYLLILAENAALSA---LWYLYRS----- -------PLATDAFAVPALCVIFSSFLTG----VVFMLMYYAFFHPNGPRFG---------------------------- -------------------------------------RSMSGHGLNLDPT----------AQFSTLPSEVATNSLRSNRG A-TATLERD---AGKYSERDGCMPVFQVRPTVPSTPS------SRAPRLEETVIKIDLCRNRYPAWERHVLDRSIRKAIL AVD-CSLTPPRLQYKD-DALVQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Gasterosteus_aculeatus_XKR4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------RSAYYSFCVWF-GQSVIHILQM GQIWRYFHTIYLGVRSHQSAE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------TERWRYYWRMVY-EFADVSML HLLATFLESA---PQLVLQLCIIIQTHKLQA-VQG-----------------------MTAAASLVSLAWALASYQKALR ESRDDK----KPISYLAVVIQFCWHFFTIAARVITFALF-----------ASVFQLYFGIFIVLH-WCIMTFWIVHCETD FCISK--------------WEEIVFDMVVGIIYIFTWFNVKEGRTRCRLFIYYLVILVENAALSA---LWYLYRS----- -------PHTTDAFAVPALCVIFSSFLTG----VVFVLMYYAFFHPNGPRFG---------------------------- -------------------------------------RSPSGQGLDLDPS----------AQFSTLPYEGTTNSLRSNRG A-TATLERD---GGKYSERDGCMPVFQVRSTVPSTPS------SRAPRLEETVIKIDLCRNRYPAWERHVLDRSIRKAIL AVD-SSLTPPRLQYKD-DALVQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Oryzias_latipes_XKR4_a --------------MAAKSDGVLKMKKSDVAFTPLQNSEHSGSVQGLH-------------------------------- ----PGEQPDS-ACADGDFINGESRCCGGVGSNSTCLRLGAELQQYSLWDCLWILAAVAVYVADVGTDVWLSVDYFLHGD ------YWWFSLTLFFVMLGSFSVQLF-SFRWFVHDFSTEDSAESAADCF-------HVDGKKLLSGSASHGDVTAQQHP GAPQRQASTASKNTASNS----------------------------TASAALGGRGTRRSRHYTFCIWF-GQSVIHILQL GQIWRYLRTIYLGVRSRQSAE----------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------SERWRWHWKMVY-EFADVSML HLLATFLESA---PQLVLQLCIIIQTHKLQA-VQG-----------------------MTAAASLVSLAWALASYQKSLR DSRDDK----KPVSYLAVIIQFCWHFFTIAARVITFALF-----------ASVF-LYFGIFIVLH-WCIMTFWIVHCETD FCISK--------------WEEIVFDMVVGIIYIFSWFNVKEGRTRCRLFIYYFVILVENAALSA---LWYLYRI----- -------PKTTDAFAVPALCVIFSSFLTG----VVFLLMYYAFFHPNGPRFG---------------------------- -------------------------------------RSPSGQGLNLDPT----------AQFATLPSEGATNSLRSSRG A-SSTLERD---AGKYSERDGCMPVFQVRPTVPSTPS------SRAPRLEETVIKIDLCRNRYPAWERHVLDRGIRKAIL AVE-CSVTPPRLQYKD-DALVQERLEYETTL------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Drosophila_melanogaster_XKR4 -------------------------------------------------------------------------------- ---------------------------MASAEQRTEVDALMMGPISKLSMLLTVVSILWR-FVSICINWSLAYVYWMEES ------YGYCAWTIGSILVPMVVTS----VIYIHTLKS------------------------------------------ ----------------------------------------------AHAGEKRILERG--------VYSNAVISYLFR-- -----DVYVLNYAFKYSLAKERDDKQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------AEIEYYQKLMTEECNVSFV RLFDSFLESAP---QKILQLAILLQSTLEFTYYR-----------------------HIALIVYFGNIAWCIQAYNHSNR LAQLDKHD--IAA--KGRFLQFLFLLCLTVSRTLCIAYV-----------ASIFPIETLIICATLACFYGTIVFFVDSPM IAKSR--------------PMNYSYCLCFGVVYLFIFTPVKDAPTKYKYAFYLTFCLLQNIIACA---LY---------- -------------IPLYLATAIIALYIVG----IVLLIIYYTYCHPNTVRTYF--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Amphimedon_queenslandica_XKR4 --------------------------------------------------------MAIIDSNFTLQLVLSPLLIVFASV VSSAVSLLLTLLVYILSDRLHAERRRVVIPAYIVTFLWHLFVIPSRIFAMVLFAVAYGPYVAVVVGVHWGAAIIWTLAER TNFCGDLSTTPPKKRYLLELPFVGVVSFIFLFIYFNVRDGSTMVRIIVYHLLTAVETLLLSALFYVAYPNLSLSPWVFAL SVSSYGLG------------------------------------VAFMFLYYAAWHPSRTEDCFLCIGCPKSCECCPCFS DKGELHLGNVDLPLDGERRRDNPRDEERSSGGDIEGEERPVTG------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------RRTPNQNGFYPSTPHRAGSSSM NNINRSTGGTPTHVRPSLQLNNHFSSAVEIPRNTSLYGGSGGGEENPYSLPFHHVGVPHTGALSLENIKRVSPYRAPSRG SLREGEEKRWPVKTKTENLPRRMLPLVTNASDPRSTPLPRRGSDSQLLPGASLNKSKYSNFNGKQRHSMIVHPDLQLSSN INLPSPIGEEPGALDGGRKWSSPLPILHVSSADSPGRGRGERGRGRGRIAKERRGSGSLLPSPYSS--FMYVTPPTPTVN TSMAASSSSLNPSYPVRSSSQLETRFYLEPGAGIGVKRYRHRSLSPDVHSSEGSGCG----------------------- ---------------------------------------YPAYSRSANATPKQSPYSSCRSSSGCAPRKRRSGSSNPLHS GDPMVEFTQLYTSGASPTHMRRPSSRSSARVSTTCDESSDCGAGRRGRTSACSSGVFSSDKSDTGFSVPPTGSEVNEPRP VLGVESNDGCGRGEERGRKDKRWQPSVNSDVGVMGGDTLV---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Homo_sapiens_XKR5 -------------------------------------------------------------------------------- ------------------------------------------------MHARLLGLSALLQAAEQSARLYTVAYYFTTGR -------LLWGWLALAVLLPGFLVQAL-SYLWFRADGHPGH--------------------------------------- --------------------------------------------------------------CSLMMLHLLQLGVWKR-- -----HWDAA---------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------LTSLQKELEAPHRGWLQLQEADLSAL RLLEALLQTGP---HLLLQTYVFLASDFTDI-----------------------VPG-VSTLFSWSSLSWALVSYTRFMG FMKPGHLA--MPWAALFCQQLWRMG--MLGTRVLSLVLF-----------YKAYHFWVFVVAGAH-WLVMTFWLVAQQSD IID---------STCHWR----LFN-LLVGAVYILCYLSFWDSPSRNRMVTF--YMVMLLENI-----ILLLLATDFL-- -------QG-ASWTSLQTIAGVLSGFLIG----SVSLVIYYSLLHPKSTDIWQGCLRKSCGIAGGDKTERRDS-PRATDL AGKRTESSGSCQ---------GASYEPTILGKPPTPEQVPPEAGLGTQVAVEDSFLSHHHWLWVKLALKTGNVSKINAAF GDNSP-AYCPPAWGLSQQDYLQRKALSAQQELPSSSRD------PSTLENSSAFEGVPKAEADPLETSSYVSFASDQQDE APTQNPAATQGEGTPKEG------ADAVSGTQGKGTGGQQR-----------------------GGEGQQSSTLYFS--- --ATAEVATSSQQEGSPATLQTAHSGRRLGKSSPAQPASPHPVGLAPFPDTMADISPILGTGPCRGFCPSAGF------- ----PGRTLSISELEEPLEP-------KRELSHHAAVGVWVSLP--QLRTAHEPCLTSTPKSESIQTDCSCREQMKQEPS FFI----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Pan_troglodytes_XKR5 -------------------------------------------------------------------------------- ------------------------------------------------MHAGLLGLSALLQAAEQSARLYTVAYYFTTGR -------LLWGWLALAVLLPGFLVQAL-SYLWFRADGHPGH--------------------------------------- --------------------------------------------------------------CSLVMLHLLQLGVWKR-- -----HWDAA---------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------LTALQKEPEAPHRGWLQLQEADLSAL RLLEALLQTGP---HLLLQTYVFLASDFTDI-----------------------VPG-VSTLFSWSSLSWALVSYTRFMG FMKPGHLA--MPWAALFCQQLWRMG--MLGTRVMSLVLF-----------YKAYHFWVFVVAGAH-WLVMTFWLVAQQSD IID---------STCHWR----LFN-LLVGAVYILCYLSFWDSPSRNRMVTF--YMVMLLENT-----ILLLLATDFL-- -------QG-ASWTSLQTIAGVLSGFLIG----SVSLVIYYSLLHPKSTDIWQGCLRKSCGIAGGDKTERRAS-PRATDL AGKRTESSGSCQ---------GASYELTILGKPPTPEQVPPEAGLGTQVAVEDSFLSHHHWLWVKLALKTGNMSKINAAF GDDNP-VYCPPAWGLSQQDDLQRKALSAQRELPSSSRH------PSTLENSSAFEGVSKAEADPLETSSYVSFASDQQDE APTQNPAATQGEGTPKEG------ADAVSGTQGKGTGGQQR-----------------------GGEGQQSSTLYFS--- --ATAEVATSSQQEGSPATLQTAHSGRRLGKSSPAQPASPHPVGLAPFPATMADISPILGTGPCRGFCPSAGF------- ----PGRTLSISELEEPLEP-------TRELSHHAAVGVWMSLP--QLRTAHEPCLTSTPKSESIQTDCSCREQMKQEPS FFI----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Gorilla_gorilla_XKR5 -------------------------------------------------------------------------------- ------------------------------------------------MHAGLLGLSALLQAAEQSARLYTVAYYFTTGR -------LLWGWLALAVLLPGFLVQAL-SYLWFRADGYPGH--------------------------------------- --------------------------------------------------------------CSLVMLHLLQLGVWKR-- -----HWDAA---------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------LTALQKEPEAPHRGWLQLQEADLSAL RLLEALLQTGP---HLLLQTYVFLASDFTDI-----------------------VPG-VSTLFSWSSLSWALVSYTRFMG FMKPGHLA--MPWAALFCQQLWRMG--MLGTRVMSLVLF-----------YKAYHFWVFVVAGAH-WLVMTFWLVAQQSD IMD---------STCHWR----LFN-LLVGAVYILCYLSFWDSPSRNRMVTF--YMVMLLENI-----ILLLLATDFL-- -------QG-ASWTSLQTIAGVLSGFLIG----SVSLVIYYSLLHPKSTDIWQGCLRKSCGIAGGDKTERRAS-PRATDL VGKRTESSGSCQ---------GASYELTILGKPPTPEQVPPEAGLGTQVAVEDSFLSHHHWLWVKLALKTGNVSKINAAF GDDSP-VYCPPAWGLSQQDYLQRKALSAQRELPSSSRH------PSTLENSSAFEGIPKAEADPLETSSYVSFASDQQDE APTQNPAATQGEGTPKEG------ADTVSGTQGKGTGGQQR-----------------------GGEGQQSSTLYFS--- --ATAEVATSSQQEGSPATLQTAHSGRRLGKSSPAQPASPHPVGLAPFPATMADISPILGTGPCGGFCPSAGF------- ----PGRTLSISELEEPLQP-------TRELSHHAAVGVWMSLP--QMRTAHEPCLTSTPKSESIQTDCSCSEQMKQEPS FFI----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Mus_musculus_XKR5 -------------------------------------------------------------------------------- ------------------------------------------------MHAGLLGLSALLQAAEQSARLCSIVFYFATGR -------LLWGWLALSVLLPGFLVQAL-SFLWFRADGHQGQ--------------------------------------- --------------------------------------------------------------WWLAVLHLLQLGVWKR-- -----HWDSV---------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------ATALWKGKEAPSWGQLHLQEADLSAL RLLEALLQTGP---HLLLQAYVFLASDFTDI-----------------------VPG-ISALLSWSSLSWALVSYNRFLG IMKPGHHT--MLWAALLCQQLWRMG--MLGARVLSLVLF-----------CRVYRVWVLVVGGAH-WLVMTFWLVAQQSD IVE---------STCHWR----LFN-LLVGAVFILCYINFWDSPSRSRVASF--YLVMLLENS-----ILLLLATDFL-- -------QG-VPGTSLWTVVGVLSGFLIG----CASLVIYYSLLHPKSSDIQQSFMRKCCGPIEDNKPESEPP-PRAVDP TGEMPDSSSWCQ---------EESYELTSLDKAPSPEQNTAEVGLGEQRSGESSFFSHHHWLLLKLALKTGSVSRINAAL GGDSPGCSCPPLLGSSQHCDLQRKPLFSHQDLPSSPCD------PLTLEKGSEYVGAPKAEMESLETSSYLSFASELEDN ATTQKPPATQEDSPKLAG------SKADLAAQGKETEGPLQ-----------------------GKEGQESTTLYFS--- --AAMDR-TTSHQRGSPVVLRISHSET-LVESRPGQPALPQAV-TKPFPVTVANISPIPG----RNFRPSAEL------- ----PGRAPDSSECEEWKDA-------ARDPSMQS------SLPKMRLKAAEEPCFTSTPKSESIQRDYSCRDRVRQEMS FFI----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Rattus_norvegicus_XKR5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MKPGHRT--MLWAALLCQQLWRMG--MLGARVLTLVLF-----------CRVYRVWVLVVGGAH-WLVMTFWLVAQQSD IVE---------STCHWR----LFN-LLVGAVFILCYINFWDSPSRSRMASF--YLVMLLENS-----ILLLLATDFL-- -------QG-APWTSLWTVVGVLSGFLIG----CASLVVYYSLLHPKSSDIQENFMRKCCGPIENNKSDSEPP-PRAMVP TGERPDSSSWCQ---------EKSYELTSLDKAPSPGKSTAELRLEEQRSGEDSFFSHHHWLLLKLALKTGSISKINAAL GGDSPGCSCPPRLGSSQHCDLQRKPLFSQQDLPSSPRD------PLTLEKGPEYVGAPKAEMESLETSSYISFASDLEDN ATTQKPPATQEDSPK-AG------TKADLAAQGKDTDGPLK-----------------------GKEGQESTTLYFS--- --ATMDR-TTCHQKGSPVALRTSHLGT-LGESRPVQPALPQAV-TKPFPVALANISPIPG----RNFCPDAGL------- ----PGRAPESSEWEEWEDP-------AKNPSTQS------SLPKVRLRAAEEPCVTSTPKSESIQRDYNCRDRVKQEVS FFI----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Canis_familiaris_XKR5 -------------------------------------------------------------------------------- ------------------------------------------------QRGGLVFLNARTRCQSRPAGLCCVVHYFTTGQ -------LLWGWLALALLLPGCLVQVL-SYLWFRADGQQGH--------------------------------------- --------------------------------------------------------------GLLVVLHLLQLGVWKR-- -----HWDAA---------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------SSALSKEGEASRRDQLLLQEADLSAL RLLEALMQTGP---HLLLQTHVFLASDFTEL-----------------------VPG-VSALCSWAALSWALVCYARLAG LLKPGRLP--VPWAALFCQQLWRMG--MLGARVLSLALF-----------SRAYHAWVLVVGGAH-WLVMTFWLVAQQSD VVD---------STCHWR----LFN-LLVGAVYILCYLNFWDSPSRHRMAMF--YTIMLLENI-----VLLLLATDFL-- -------QG-ASQTSLWTIAGVSSGFLIG----SVSLVTSYGLLRPPSAGGRRG-----RGVAAGDGADAESC-PRGPAP ARG---SPGAGQ---------EDGGEFTALGRAPGPQWGPPEAGLESLTAREDPFFSHHHWLLLKLALKTGNMSKINAAF GEDSPGRFGPPARGVGQHSAQQGTPLFPQQELPPSPPG------PQASEKGSGIPGVLSAEADLLEASSFASLAGDKHDQ APGQKRPPAPTQGRPGEG------AGAASPLQGR-AAGART-----------------------GAQGLEGSTRDFS--- --ATAEGGPSPQQEGGQATPHTCAPGRRP--RSPPRPAP------RPFPAAVADISPILRPGLSRSF------------- ----VGTAPGSSERGEQREP-------TTDRNLP----ELLSLPKRSLWPADQPCLTSTPKCE----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Felis_catus_XKR5 -------------------------------------------------------------------------------- ------------------------------------------------RHQKTQCRRAWLAAREEPARLCSVVYYFITGQ -------PLWGWLALSVLLPGFLVQGL-SYLWFRADGHQGH--------------------------------------- --------------------------------------------------------------CLLVMLHLLQLGVWKR-- -----HWDAA---------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------STALQKEREASSRGQLLLQEADLSAL RLLEALLQTGP---HLLLQTHVFLASDFTDV-----------------------VPG-VSALCSWSALSWALVCYACFMG FVKPGHVF--TPWAALLCQQLWRMG--MVGARVLSLVLF-----------FGAHRVWVLVFGGAH-WLVMTFWLVAQQSD IID---------STCHWR----LFN-LLVGAAYILCYLNFWDSPSRNRMAMF--YTIMLLENI-----VLLLLATDFL-- -------QG-ASRTSLWTIAGVLSGFLIG----SISLVVYYSLLHPKSTDIWRGFVTEVRGTAVGDRAERGSS-PRASAA AGE---RPGS-P---------GDSCELTHLGRAPSPQWGPPEAGLESQIVQEDSFLGHHHWLLVKLALKTGNVSKINAAF RKDGPGFFGPPEWGLSQHRNHQMTPRFSQKELASSPHD------PLSSDKGCESQVVRKAEADLLDTSSYVSLAGDNPDE APGRRWSAAPREGSPREG------AEAVSPLQGR-GAGDRR-----------------------GRAGQESATLYFS--- --ATAEGATSPQREAGQATSQTPLSGRSS--EPSPRPAT------RPFPATMASISPILGPGRTGSFRPSTGL------- ----PGRALGGSERGGQQEP-------MGDPNLPTIAGTRMALPEVSLRPADEPCLTSTPKCEPAHGDCGGRARPRTMPS FSM----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Monodelphis_domestica_XKR5 -------------------------------------------------------------------------------- ------------------------------------------------MHAGYLVICALLLAAEQGARLCTVVYYFHTKQ -------YLWAWLTLSTLLPGCLIQGL-SYLWFLADGHQGS--------------------------------------- --------------------------------------------------------------CSLVIVHLLQLGTWKR-- -----HWDTF---------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------LTTMTKEEESPDMRKVLLHQGDLFVL RLLEALLQIGP---HLLLQAYAFISADFQDP-----------------------VPG-VSAVLSWLSLSWSLVSYTRIMS LIKPGHLA--MPWAALLCQLLWRLA--MLGTRIITLVLF-----------SQAYHCWVLVVGGAH-WLVMTFWLVAQQSD IID---------STCCWR----LFN-LLVGALYVFCYINFWDSPSRNRMTTF--YTIMLMENI-----ILLLLATDFL-- -------QG-ASWGTMWMTIGIVSGFIIG----CASLVIYYSLLHPKSTEIWQGFIRKFCGSVDSDKTEKEPSSFQCTKP VEEKSESLGLYPV--------EDPKDPKYQGNSLSMDWGASTG--SQVVRDEATAKCHHHWLLVKLALKTGNMSKINAAF GNGGLDCFCPPIYITSKCFGPQMKLSFLEKEFPLPQKH-CGPPCQTSWQKDSQAEDIPETKEDPLETSSFITL--SSHQH VHAPTHKTIQTKVPWRPE----------KSISESPIGQGGG-----------------------KGRRQENSTFYFS--- --ATMEGATPSHHEARTAPPVSCRKVDIEKDQQTNSDPNHLV--PKPFPISVANISPILGTSTAHRLRHNTGLYNG---- ----SQCSLPGVSSAGSRRPL---ELWTAPGNSFLSVGTWVSMIRSKLKPSGEPYCTSTPKSEPRKDGDSLRERLRQESN LFF----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Xenopus_tropicalis_XKR5 -------------------------------------------------------------------------------- ------------------------------LTVGKRFSPGRCGMEASGSSVGCAAVSLLLYLMERGAELAVLVHYFLTGQ -------YTWASCTLALLIPGCLVQAL-SFAWFRKEGPAGG--------------------------------------- --------------------------------------------------------------FTVTLIHVLQLGILKR-- -----QADCLQ--------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------VALREGKRQKPGNERELLMQQGDAALL RLVEALLQALP---HLLLQTYIYLALEYTN------------------------AYAVASALLSLLSLSWALVSYSRFLC LLKPGHLS--MPWASLLCQLLWRMG--MIGTRAMALAVF-----------ARVYHFWVFAVAGAH-WLVMSFWLVAQQTD LIS---------RPCYWK----LFN-ALVGAVYVFCFLNVRDGPSRYRVAIF--YTVMLLENA-----ILLLLATDFL-- -------QG-VLWSNVRLTVVVMCGFLIGENGGLMDLQVNMSSFHISVANVILYCTRSNCLSIAFSLPPPPATCNMIKGL GEVMRKDMASQP---------WLAFPTAVRTTAPICVCFCSQYLPYELSFSIYPTLTDWRHYYIVYSGGILILELLCRIY TVASLPTDYKETYGDQHSKYGNTNLCRKHRAMGLIQSN-----------KETPIQLMIRLLHSANVEPEKPGAASVEPIQ TPTKEIPAQEGARTEVYP--------AICVSPILSLATNSN--------------------------FQRSIAPDVG--- --SLCDDSSMSNDEADVTEAEELPGEKARLLLAPGLLAPSLRG------------------------------------- ----------------------------------------------RLIPEEKPCFTSTPKPQTASAEPGLREDSKTKRK LLEP---------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Danio_rerio_XKR5_a -------------------------------------------------------------------------------- ------------------------------------------------------MWMLLTLCLSSSSVVCCVAFYLWQEQ -------LCFAGWTFALLLPGSLVQVL-SFRWYRADGDTHT--------------------------------------- --------------------------------------------------------------CHNFIIHTLHLGIFKR-- -----FWDCAV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------CEWTSPGSAGSHAQEVMQQADVSAL RLLEVLLMTVP---QTLLQTYALTVTDYGLS-----------------------SPVALCSGVCLLSLSWALVLYSRACC LIRPGHLQ--MPPAALLSQLLWRTG--MLAARFTSLALF-----------TRTFGCWLIGVIASH-WLMAALWLVSQQTD IYV---------GQWSWR----VFN-FILGGVHVFLFLNVKDGPSRFRMAGF--YTVMLLENA-----TLLLAASEIL-- -------ID-ASWDSLTIPTAVLCSFLLG----LTSLILYYRFLHPKSTEISQGLHQR--AHMGRECLQQADSSFSLGDK HLPPAALPVLFR-----------SSHPSFS-LSGIPGSLLEHPGSCGVKPDG--ECRHHHWLLIRLALKTGDPVKINSAY GAGGVSGILAVDQKAEMIDD------------GCISAS-------ESRDDTMAPLSDCREEFESMSEAKDDDD---EDDS LEMESPLESPVTLSDCKRS------SPEGKS-VFGDSPEPN-----------------------YCPTESSSTLYFS--- --ADPQSPSSSSNPRLDRETPFSFGSGTGLETLDELSPISTDG-----GLHRDXXXXGQRASGPGGSLLHFRTR------ ----------------------------------------------VKWRGFGITPQGPSQAGGFVP------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Danio_rerio_XKR5_b -------------------------------------------------------------------------------- -------------------------------------MQNRKGSEITWSHVCLYSFSGLIVLLEKAALVLCFTHYLITGQ -------ELLAWLTAALCLPISAVQML-SLKWYITDEERPK--------------------------------------- --------------------------------------------------------------PSVILLHCLHLGVYHR-- -----LWSCMK--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------SQAEQ----VQFGAVLIQQADVSVL CLIEALTLSLP---QSLLQTYSLFTLHPGLL-----------------------SPVVVCIGLSLLNVSWFVVLYSRSCF LLRPAHLH--MTPAALLCQFIWRAG--MLSARVTSLMLF-----------CSTFHWWTCGVLGFH-WLIMMFWQVSQQTD ICI---------NRGSWR----LFN-FILGALYIFIFVNVKDGPSRYRMTGF--YLLMLLENT-----FLLLLASDSF-- -------SG-PSWDSMSVPLTVSCSFLIG----VIFLILYYRFLHPKSTEILQSLRL----QMSLTTIDKTDTDCK--DT TLESSTH-----------------KHGTFS-LTGFPPAQHLHPLEGDG---------HHHHMLIKLALKTGNHDKINSMY GNRGLSVILGKNDAKDEDLG----------------------------------------------------------ES GCKRSSVEAGKASENYQIES----TSAAEVKQVSLEKIEYN-----------------------SCPVDCSSTVYFS--- --AEAQS-YSVSDSILEKDK------------MAAISPIVNGD-----EVHLIGKQLLNR-NPCYTSTPIADFK------ ----------------------------------------------TMQTVGDR--LGGVRRQVQF-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Tetraodon_nigroviridis_XKR5_a -------------------------------------------------------------------------------- -----------------------------------------------------------------LPVIYCIGFYLWNEE -------MQWAGLTLGLFLPGTAVQLL-SMKWYRDDGDDRR--------------------------------------- --------------------------------------------------------------CYLSVIHILHLGIFKR-- -----LWDCMR--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------VVLRRQDSVAELGASIMQQADVAAL WLLEALVLTLP---QSLLQAYVMVSTDVGFV-----------------------SPVGCSCGLCVLSISWALVLYNRACC LIRPGHLA--MPPAAMLCQLVWRAG--MLGARVACLMFF-----------ARVFNWWVCGVAGFH-WLTASFWLISQQPD ICT---------GPWCWR----AFN-GIMGLVHVFLFLNVKDGPSRFRMASF--YAFMLVENA-----TLLLAASDFL-- -------SE-ASWDNMTLPTTVLCSFVLS----ATSLILYYRFLHPKSTEICQGTDH---NHVGSTCIEGGESSFSLGDK SLPVPSI----------------QNHGSFS-YSGVAGSLLDHPGTCGGQPNNSCPCYHHHWLLIRLAMKTGDLGKINRAY GAGGAAAILDMEEYAQDIKGQDSNTLTVGGSCGGISNS-------VSQEKGLAPLSDCKDEFQTISEPTSIEHPE-EDDS LEMESPLESP--MSDFKRS------SPEGKS-VFGDSPEPY-----------------------FCPTESSSTLYFS--- --ADPQSPSSASNTRLDRDI-------GGLEQGVRLNSLPSDP-----ALHRDVRGLMGRVGPRCTSTPRLDSG------ ----------------------------------------------ALDNPPNIPHLTGPRRQLIMSQRDEDEIF----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Tetraodon_nigroviridis_XKR5_b -------------------------------------------------------------------------------- ----------------------------------------------------------------SPAVIYCFVYYLWVGH NY---CYAYLAGFTALFLLPGWGPQWL-SYLWYLSDGRIRR--------------------------------------- --------------------------------------------------------------RSLTWTHLLHLGLFKR-- -----LWECTC--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------QAEE------DVYGYIMQQADVSAL RLLEALVVTLP---ETLLHTYVLICTDIGIK-----------------------SPASVCFAVCLLSLAWALVLYARACS LIRPGHLQ--MTPAAVLCRLLWRVGLRMLGSRFAVLMLF-----------TRVFKQWVLGVVGVH-WLGATFWMVSQQSD IIR---------STSRWR----LFN-LVLGAIHIFFFLNVKYGQSRCRMAGF--YLVMFVENA-----FLLLASSWLF-- -------SM-VSWDTVGIPAAVLCSFLIAG---VISLVLYYRFLHPKSFEIFQSIRR---RGLGGACTERG-STLSLEEK VTPTFHR------------------QAS-------GGTLMDLPLQWEG-------WKHHHWLLIRLALKTGAVTRIWSAY GEGGLAGLMGLSEEFHSP----------------DDFR-------VPQG-SPTPP--------SPQQPGSLCHIDSNAGT LTEASSSAG---SLDIKTPG----WSPERRSPFLIGSPEKKP----------------------GASGESSTTLYFS---