>Homo_sapiens_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRLG---LCVVALVLSWTHLTI---SSRGIKGKRQRRISAEGSQAC---------------------- -------------------------------------AKGCELCS------------------------EVNGCLKCSPK LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------ ----HNFCTKCKEGLYL-------------------HKGRCYPACP-------EGSSAANGTMECSSP------------ ------------------------------------AQCEMSE-------------------------WSPWGPCSKKQ- ---------------------QLCGFRRGSEERTRRVLHAPVGDHA-----------------------ACSDTKETRRC TVR-RVPCP----------------------------------------EGQKRRKGGQGRRENANRNLARK-------- --ESKEAGAGSRRRKGQQQQQ--QQGTVGPLTSAGPA------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Gorilla_gorilla_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRLG---LCVVALVLSWTHLTI---SSRGIKGKRQRRISAEGSQAC---------------------- -------------------------------------AKGCELCS------------------------EVNGCLKCSPK LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------ ----HNFCTKCKEGLYL-------------------HKGRCYPACP-------EGSSAANGTMECSSP------------ ------------------------------------AQCEMSE-------------------------WSPWGPCSKKK- ---------------------KLCGFRRGSEERTRRVLHAPVGDHA-----------------------ACSDTKETRRC TVR-RVPCP----------------------------------------EGQKRRKGGQGRRENANRNLARK-------- --ESKEAGAGSRRRKGQQQQQ--QQGTVGPLTSAGPA------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Macaca_mulatta_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRLG---LCVVALVLSWTHLTI---GSRGIKGKRQRRISVEGSQAC---------------------- -------------------------------------AKGCELCS------------------------EVNGCLKCSPK LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------ ----HNFCTKCKEGLYL-------------------HKGRCYPACP-------EGSSAANGTMECSSP------------ ------------------------------------AQCEMSE-------------------------WSPWGPCSKKK- ---------------------KLCGFRRGSEERTRRVLNAPGGDHA-----------------------ACSDTKETRRC TVR-RVPCP----------------------------------------EGQKRRKGGQGRRENANRNLARK-------- --ESKEAGTGSRRRKGQQQQQ--Q-GTVGPLTSAGPA------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Mus_musculus_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRLG---LCVVALVLSWTHIAV---GSRGIKGKRQRRISAEGSQAC---------------------- -------------------------------------AKGCELCS------------------------EVNGCLKCSPK LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------ ----HNFCTKCQEGLYL-------------------HKGRCYPACP-------EGSTAANSTMECGSP------------ ------------------------------------AQCEMSE-------------------------WSPWGPCSKKR- ---------------------KLCGFRKGSEERTRRVLHAPGGDHT-----------------------TCSDTKETRKC TVR-RTPCP----------------------------------------EGQKRRKGGQGRRENANRHPARK-------- --NSKEPGSNSRRHKGQQQPQ---PGTTGPLTSVGPTWAQ---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Oryctolagus_cuniculus_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRLG---LCVVALTLSWVHLAA---GSRGIRGKRQRRISAEGSQAC---------------------- -------------------------------------AKGCELCS------------------------EVNGCLKCSPK LFILLERSDIR------------------QVGVC---------------------------------------LPSCPPG YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------ ----HNFCTKCREGLYL-------------------HKGRCYPACP-------EGSTASNGTLECGSP------------ ------------------------------------AQCEMSE-------------------------WSPWGPCSKKK- ---------------------KLCGFRRGSEERTRRVLHAPAGDHT-----------------------ACSDTKEARRC TVR-RTPCP----------------------------------------EGQKRRKGGQGRRENTHRNLARK-------- --DSKETGAGSRRRKGQQQQP----GTARPFTTAGPT------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Bos_taurus_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRLG---LCVVALVLSWMHLAA---GSRGIKGKRQRRISADGGQAC---------------------- -------------------------------------AKGCELCS------------------------EVNGCLKCSPK LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------ ----HNFCTKCQESLYL-------------------HKGRCYPACP-------EGSAPADGTMECSSP------------ ------------------------------------AQCEMSE-------------------------WSLWGPCSKKK- ---------------------KLCGFRRGLEERTRRVLHAPGGDHA-----------------------VCSDTKETRKC TVR-RTPCP----------------------------------------EGQKRRKGSQGRRENANRNPGRK-------- --ESKEAGTGARRRKGQQQQQ---QGTEGPVTSLGPT------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Dasypus_novemcinctus_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRLG---LCVVVLVLSWMHLAA---GSRGTKGKRQRRISVEGSQAC---------------------- -------------------------------------AKGCELCS------------------------EVNGCLKCSPK LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------ ----HNFCTKCKESLYL-------------------HKGRCYPACP-------EGSAAANGTMECSSP------------ ------------------------------------AQCEMSE-------------------------WSPWGPCSKKK- ---------------------KLCGFRRGSEERTRRVLHVPAGDHA-----------------------ICSDTRETRRC TVQ-RTPCP----------------------------------------EGQKRRKGGQGRREKVNRNPDRK-------- --ESKEAGTGSRRRQGLQQPQ--QQGTAGPVTSAGPT------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Myotis_lucifugus_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRLG---LCVVALVLSWMHLTA---GSRGIKGKRQRRISAEGSQAC---------------------- -------------------------------------AKGCELCS------------------------EVNGCLKCSPK LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------ ----HNFCTKCKESLYL-------------------HKGRCYPACP-------EGSAAANGTMECSSP------------ ------------------------------------AQCEMSE-------------------------WSLWGPCTKRK- ---------------------KLCGFRRGSEERTRRVLHAPGGDHA-----------------------ICSDTKEIRRC TVR-RTPCP----------------------------------------EGQKRRKGGQGRREKANRNPSRK-------- --ESKEAGTGSRRRKGQQQPQQQQQGTVGPLTSAGPT------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Ornithorhynchus_anatinus_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQLG---LFAVLVILSWTDLAG---GSKVAKGKRQRRISTEVSQGC---------------------- -------------------------------------AKGCELCS------------------------EFNGCLKCSPK LFILLERNDIR------------------QIGIC---------------------------------------LPSCPPG YYDARNPD-------------------MNKCIKCKIENCDACFS------------------------------------ ----QNFCTKCKEGLYL-------------------HKGRCYPDCP-------SGYSAANGTMECSSP------------ ------------------------------------AHCEMSE-------------------------WSSWGPCSKKK- ---------------------KLCGFRKGTEERARRVLNAPTGDRS-----------------------GCPPAREVRRC TVQ-KSLCP----------------------------------------EGPKRRKDEQGKRENGNGNHNRK-------- --EAKEARSGSRRRKGQQQQQQQQRGTVLPLTLAGPD------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Gallus_gallus_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQLG---LFVVVVFLSSMDLTG---GSKVVKGKRQRRISTELSQGC---------------------- -------------------------------------ARGCDLCS------------------------EFNGCLRCSPK LFILLERNDIR------------------QIGIC---------------------------------------LPSCPLG YFGLRNTD-------------------MNKCIKCKIENCESCFS------------------------------------ ----RNFCTKCKEGLYL-------------------HKGRCYVTCP-------EGYSAANGTMECSSP------------ ------------------------------------AQCEMSE-------------------------WGPWGPCSKKR- ---------------------KLCGFKKGNEDRTRRILQAPSGDVS-----------------------LCPATTEVRRC TVQ-KSQCP----------------------------------------EGKRKKKDEQGKQDNTNGNRNRK-------- --DTKDAKSGTKKRK------SKQRGAVAPTTSASPAQ------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Pelodiscus_sinensis_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQLG---LFLVVVFLSLMDLAG---SSKVVKGKRQRRISSEVSQGC---------------------- -------------------------------------AKGCDLCS------------------------EFNGCLKCSPK LFILLERNDIR------------------QIGIC---------------------------------------LPSCPLG YFGVRNPD-------------------MNKCIKCKIENCEACFS------------------------------------ ----RNFCTKCKEGLYL-------------------HKGRCYSTCP-------EGYSAANGTMECSNP------------ ------------------------------------AQCEMSE-------------------------WGPWGPCSKKR- ---------------------KLCGFKKGNEERSRKVLLAPSGDVS-----------------------VCPATTEVRKC TVQ-KNQCP----------------------------------------EGKRKRKEEQEKRDNMNGNRNQK-------- --DTKEAKSGTKKRK------SQQRGTVVPMTLASPAQ------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Xenopus_tropicalis_RSPO1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQFG----LFAVLVLILMDIAD---SNKFVKGRRHRRRSTEVSMVC---------------------- -------------------------------------AKGCDLCS------------------------EFNGCMKCLPK LFILLERNDIR------------------QTGIC---------------------------------------LQSCPQG YFDDRNRE-------------------NNRCLKCKINNCETCFS------------------------------------ ----KNFCTKCKEGFYS-------------------HKGSCYSSCP-------EGFSAVNGTAECSS------------- ------------------------------------VQCEMSE-------------------------WGAWSPCSRTG- ----------------------QCGRKKGTEERSRIVVKAPLGDLA-----------------------LCPPTTERRKC TMP-KIPCT----------------------------------------NRSLGMLKNQNKQELSKRKKEKN-------- --SKTQIEQDGSLKRNKSQQK----VTSIPSTPSLPVQ------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Danio_rerio_RSPO1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MHLG--LLALALVFFSSMGHAD---NLKASKARRQRRISTEVPPSC---------------------- -------------------------------------SNGCEHCS------------------------EYNGCLKCRPR LFILLERNDIR------------------QIGIC---------------------------------------LAACPVG YYGIRNRD-------------------MNKCTQCKIENCEACFS------------------------------------ ----RNFCTKCKEGLYS-------------------HRGRCFSSCP-------EG-FTVNGTMECVVQ------------ --------------------------------------CDLSE-------------------------WSPWGPCMKKN- ---------------------KTCGFKKGNQTRTREPL-QVPSPATSTGA---------------APASGCVPEIQTQRC TVQKKIPCK----------------------------------------G-----ENKKNQQNRGENSKNRG-------- --RDSKERGGNKKRKNTNRST-----TVPTITTSMVT------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Takifugu_rubripes_RSPO1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQLG--LVVLAMIFLSSMGHSD---ALKLSKARRQRRVSPEMPLSC---------------------- -------------------------------------PKGCDRCS------------------------EYNGCIKCKPK LFIFLERNDIR------------------QIGVC---------------------------------------LASCPIG YFGMRNPEG------------------NNRCTQCKIENCEACFN------------------------------------ ----RNFCTKCKEGLYS-------------------HSGRCYVSCP-------QDQSAVNETMECV-------------- -------------------------------------DCELGE-------------------------WSQWSSCMKKN- ---------------------KTCGFRKGSQSRSRVPLPQVHSPDTSLAL---------------VPSQTCAPETERKKC TLSKKAPCG----------------------------------------RERNGKGDQQGDTNRRERENGRG-------- --HGRNKGGGSRRKKGQSRTT-----SAPSITTSSVS------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Gasterosteus_aculeatus_RSPO1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQLG--LVALAMVFVSSVGHGD---ALRPSRGRRQRRVSTEGPPSC---------------------- -------------------------------------PKGCDRCS------------------------EYNGCIKCRPK LFIFLERNDIR------------------QIGVC---------------------------------------LASCPVG YFGMRNPEG------------------NNRCTQCKIDNCEACFN------------------------------------ ----RNFCTKCKEGLYS-------------------HSGRCYVSCP-------PGQRTANESMECVGQRA---------- ------------------------------------DECILGE-------------------------WSQWGSCMKKN- ---------------------KTCGFKKGSQSRERVPS-QVHSPDASPAP---------------EPSQTCAPQVERRKC SVT-KTPCA----------------------------------------R---GKRKIH--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Oryzias_latipes_RSPO1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQLG--LVALAMIILSSMGHSD---VVKLSKARRQKRVSTEGPPSC---------------------- -------------------------------------PKGCDRCS------------------------EYNGCVKCKPK LFIFLERNDIR------------------QVGVC---------------------------------------LASCPVG YFGMRNPEG------------------NNRCTQCKIDNCEACFN------------------------------------ ----RNFCTKCKEGLYS-------------------HSGRCYVSCP-------PGQRTANETMECVGQHA---------- ------------------------------------LKCELGK-------------------------WSQWSSCMKKN- ---------------------KTCGFKKGSQFRVRVPLQQTYAADSSSTL-----------------EETCTSQSERRKC VVP-KTPCV----------------------------------------KDRKNKGDNTNRRENRRGLGREG-------- --KDGSRGGGGKRRRGPSRTT-----TVPSITTSSVT------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Homo_sapiens_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQFR--LFSFALIILNCMDYSH-CQGN---RWRRSKRASYVSNPIC---------------------- --------------------------------------KGCLSCS------------------------KDNGCSRCQQK LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------ ----KDFCTKCKVGFYL-------------------HRGRCFDECP-------DGFAPLEETMECV-------------- ------------------------------------EGCEVGH-------------------------WSEWGTCSRNN- ---------------------RTCGFKWGLETRTRQIVKKPVKDTI-----------------------LCPTIAESRRC KMT-MRHCP----------------------------------------GGKRTPK------AKEKRNKKKK-------- ---------RKLIERAQEQHSVFLATDRANQ------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Pongo_abelii_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQFR--LFSFALIILNCMDYSH-CQGN---RWRRSKRASYVSNPIC---------------------- --------------------------------------KGCLSCS------------------------KDNGCSRCQQK LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG YYGHRAPD-------------------MNRCA------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------------KGCEVGH-------------------------WSEWGTCSRNN- ---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC KMT-VRHCP----------------------------------------GGKRTPK------AKEKRNKKKK-------- ---------RKLTERAQEQHSVFLATDRANQ------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Mus_musculus_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRFC--LFSFALIILNCMDYSQ-CQGN---RWRRNKRASYVSNPIC---------------------- --------------------------------------KGCLSCS------------------------KDNGCSRCQQK LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------ ----KDFCTKCKVGFYL-------------------HRGRCFDECP-------DGFAPLDETMECV-------------- ------------------------------------EGCEVGH-------------------------WSEWGTCSRNN- ---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC KMA-MRHCP----------------------------------------GGKRTPK------AKEKRNKKKR-------- ---------RKLIERAQEQHSVFLATDRVNQ------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Rattus_norvegicus_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MRFC--LFSFALIILNCMDYSQ-CQGN---RWRRSKRASYVSNPIC---------------------- --------------------------------------KGCLSCS------------------------KDNGCSRCQQK LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------ ----KDFCTKCKAGFYL-------------------HRGRCFDECP-------EGFAPLDETMECV-------------- ------------------------------------EGCEVGH-------------------------WSEWGTCSRNN- ---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC KMA-MRHCP----------------------------------------GGKRTPK------AKEKRNKKKR-------- ---------RKLIERAQEQHSVFLATDRVNQ------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Canis_familiaris_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQFR--LFSFALIILNCMDYSH-CQGN---RWRRSKRASYVSNPIC---------------------- --------------------------------------KGCLSCS------------------------KDNGCSRCQQK LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------ ----KDFCTKCKVGFYL-------------------HRGRCFDECP-------DGFAPLDETMECV-------------- ------------------------------------EGCEVGH-------------------------WSEWGTCSRNN- ---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC KMA-MRHCP----------------------------------------GGKRAPK------AKEKKNKKKK-------- ---------RKLIERAQEQHSVFLATDRANQ------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Bos_taurus_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------MDYSH-CQGN---RWRRSKRASYVSNPIC---------------------- --------------------------------------KGCLSCS------------------------KDNGCSRCQQK LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------ ----KDFCTKCKVGFYL-------------------HRGRCFEECP-------DGFAALDETMECV-------------- ------------------------------------EGCEVGH-------------------------WSEWGTCSRNN- ---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC KMA-MRHCP----------------------------------------GGR-----------KPDNNIGKK-------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Pteropus_vampyrus_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQFR--LFSFALIILNCMDYSH-CQGN---RWRRSKRASYVSNPIC---------------------- --------------------------------------KGCLSCS------------------------KDNGCSRCQQK LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG FYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------ ----KDFCTKCKVGFYL-------------------HRGRCFDECP-------DGFAPLDETMECV-------------- ------------------------------------EGCEVGH-------------------------WSEWGTCSRNN- ---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC KMA-MRHCP----------------------------------------GGRRAPK------AKEKKNKKKR-------- ---------RKLTERAQEQHSVFLATDRADQ------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Ornithorhynchus_anatinus_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------ASYGANPIC---------------------- --------------------------------------KGCLSCS------------------------KDNGCSRCQQK LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPLG YYGLRSPD-------------------MNRCARCRIENCDSCFS------------------------------------ ----RDFCTKCKAGSFL-------------------HRGRCFDECP-------DGFAPLEETMECV-------------- ------------------------------------EGCEVGP-------------------------WSEWGVCSRNN- ---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC KMA-LRHCP----------------------------------------GGK---------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Anolis_carolinensis_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQFR--LFSFALIVLNCMDYSH-CQGA---RWRRSKRANYGPNPIC---------------------- --------------------------------------KGCLSCS------------------------KDNGCIRCQHK LFFFLRREGMR------------------QYGEC---------------------------------------LNSCPSG YYGLRAPD-------------------MNRCSRCRIENCDSCFS------------------------------------ ----RDFCTKCKPGFYL-------------------YRGRCFGECP-------DGFMPLEETMECV-------------- ------------------------------------EGCEVGP-------------------------WSEWGICSRNN- ---------------------KTCGFKWGLETRTRQIVKKPAKDTL-----------------------PCPTIAESRRC KMA-LRHCP----------------------------------------GG--KRT------PKTKDKKKKK-------- ---------KNLMERAQKQHSLFLSTDRAGQ------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Xenopus_tropicalis_RSPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQFQ--LFSFVLIILNCVDYSH-CQAN---RWRRSKRASYGTNPIC---------------------- ----