>Homo_sapiens_RIMS3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MFNGEPGPASSGASRNVVRSSSISGEICG------SQQAGGG-------AGTTTA KKRRSSLGAKMVAIVGLTQWSKSTLQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LPQPEGATKKLRSNIRRSTE-------------TGIAVEMRSRVT---- ----RQGSRESTDGSTNSNS-----------------------SDGTFIFPTTRLGAESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPPM---------------------GDVHI-------- ---------AIMDRSG-QLEVEVIE---------------------ARGLTPKPGSKSLP---ATYIKVYLLENGACLAK KKTKMTKK--TCDPLYQQALLFDEGPQ----GKVLQVIVWGDYG-RMDH------------------KCFMGMAQIMLDE LDLSAAVTGWYKLFPT--S---------------------SVADSTLGSLTRRLSQSS-------LES------------ -------------------------------------------------ATSP----SC------------------S-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Pan_troglodytes_RIMS3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MFNGEPGPASSGASRNVVRSSSISGEICG------SQQAGGG-------AGTTTA KKRRSSLGAKMVAIVGLTQWSKSTLQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LPQPEGATKKLRSNIRRSTE-------------TGIAVEMRSRVT---- ----RQGSRESTDGSTNSNS-----------------------SDGTFIFPTTRLGAESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPPM---------------------GDVHI-------- ---------AIMDRSG-QLEVEVIE---------------------ARGLTPKPGSKSLP---ATYIKVYLLENGACLAK KKTKMTKK--TCDPLYQQALLFDEGPQ----GKVLQVIVWGDYG-RMDH------------------KCFMGMAQIMLDE LDLSAAVTGWYKLFPT--S---------------------SVADSTLGSLTRRLSQSS-------LES------------ -------------------------------------------------ATSP----SC------------------S-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Mus_musculus_RIMS3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MFNGEPGPASAGASRNVVRSSSISGEICG------SQQAGGG-------AGTTTA KKRRSSLGAKMVAIVGLTQWSKSTLQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LPQPEGATKKLRSNIRRSTE-------------TGIAVEMRSRVT---- ----RQGSRESTDGSTNSNS-----------------------SEGTFIFP-TRLGAESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPPM---------------------GDVHI-------- ---------AIMDRSG-QLEVEVIE---------------------ARGLTPKPGSKSLP---ATYIKAYLLENGACVAK KKTKVAKK--TCDPLYQQALLFDEGPQ----GKVLQVIVWGDYG-RMDH------------------KCFMGMAQIMLDE LDLSAAVTGWYKLFPT--S---------------------SVADSTLGSLTRRLSQSS-------LES------------ -------------------------------------------------ATSP----SC------------------S-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Bos_taurus_RIMS3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MFNGESGPASAAASRNVVRSSSISGEICG------SQQAGDG-------TGTSTA KKRRSSLGAKMVAIVGLTQWSKGTLQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LPQAEGATKKLRSNIRRSTE-------------TGVAVEMRSRVP---- ----RQGSRESTDGSTNSNS-----------------------SDGTFIFPTTRLGAESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPPM---------------------GDVHI-------- ---------AIMDRSG-QLEVEVIE---------------------ARGLTPKPGSKSLP---ATYIKVYLLENGACLAK KKTKVAKK--TCDPLYQQALLFDEGPQ----GKVLQVIVWGDYG-RMDH------------------KCFMGMAQIMLDE LDLSAAVTGWYKLFPT--S---------------------SVADSTLGSLTRRLSQSS-------LES------------ -------------------------------------------------ATSP----SC------------------S-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Monodelphis_domestica_RIMS3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MFDGEPGTGPAASSRNVVRSSSISGEVFGGG----GEQAGGT-------AGASTA KKRRSSLGAKMAAIVGLTQRSRSSLQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LPQPEGGPKKLPSNIRRSTE-------------TGIAVEMRSRVT---- ----RQGSRESTDGSTNSNS-----------------------SDGTFIFPTARLGAESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LGTPPM---------------------GDVHI-------- ---------AMMDRSG-QLEVEVIE---------------------ARGLTPKLGSKSLP---ATYIKVYLLENGACLAK KKTRVAKK--TCDPLYHQALLFDEGPQ----GKVLQVIVWGDYG-RMDH------------------KCFMGMAQIVLEE LDLSNVVTGWYKLFPT--S---------------------SVADSTLGPLTRRLSQSS-------LES------------ -------------------------------------------------STSP----SC------------------P-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Xenopus_tropicalis_RIMS3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MFNG---ETS-SSVRNVIRSSSISGEMYN------LEKGNSANP---DAAGVTTT KKRRSSLGAKMVAIVGLSQWSKSTLQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LNQPDGTTKKLRSNIRRSTE-------------TGIAVEMRNRVT---- ----RQGSRESTDGSTNSNS-----------------------SDGTFIFPTTRLGAESQ-FSNF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPPM---------------------GDVHI-------- ---------GMVDRNG-QLEVEVIQ---------------------ARGLTPKPGSKSIP---APYIKVYLIENGVCLSK KKTRTSKK--TWDPVYQQALLFDEGPQ----GKVLQVIVWGDYG-RMDH------------------KCFMGMAQILLEE LDLSSCVTGWYKLFPT--S---------------------SLADSSIAPLTRRLSQSS-------LES------------ -------------------------------------------------STSP----SC------------------T-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Danio_rerio_RIMS3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------MMLSSSVDVPSPG---GMSAVAARNVVRSSSISGAMYS-L----EKSPSSTGP---DGTSLTGN KKRRSSLGAKMVAIVGLSQWSKSTLQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LNQQDGGTKKLRSTIRRSTE-------------TGIAVEMRNRVT---- ----RQGSKDSTDGSTNSNS-----------------------SDGTFIFPTTRLGPESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPSM---------------------GDVYI-------- ---------GVVDRGG-QLEVEITQ---------------------ARSLTPKPGSKNIP---ATYIKVYVLENGMCLAK KKTKVVKK--TLDPTFQQSLMFDESPQ----GKVLQVIVWGDYG-RMDS------------------KCFMGMAQILLDD LDLSSMVGGWYKLFPT--S---------------------SLADPSIGPLTRRLSQSS-------LES------------ -------------------------------------------------ATSP----SC------------------T-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Takifugu_rubripes_RIMS3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------VEVPSPGGMSGLS-VAARNVVRSSSISGAMYS-L----EKSPGGGGS---DSTSLAGN KKRRSSLGAKMVAIVGLSQWSKSTQQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LNQQEGGTKKLRSTIRRSTE-------------TGIAVEMRNRVT---- ----RQGSKDSTDGSTNSNS-----------------------SDGTFVFPTTRLGPESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPPM----------------A--STGDVHI-------- ---------GIVDRGG-QLEVEVNQ---------------------ARGLTPKPGSKNIP---ATYVKVYVLENGVCLAK KKTKVVKR--NLDPTYQQALLFDESPQ----GKVLQVIVWGDYG-RMDH------------------KCFMGMAQILLED LDLSATVSGWYKLFPT--S---------------------SLADPSIGPLTRRLSQSS-------LES------------ -------------------------------------------------ATSP----SC------------------S-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Tetraodon_nigroviridis_RIMS3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------VEVPSPGGMSGLS-VAARNVVRSSSISGAMYS-L----EKSPGGGGS---DSTSLAGN KKRRSSLGAKMVAIVGLSQWSKSTQQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LNQQDGGTKKLRSTIRRSTE-------------TGIAVEMRNRVT---- ----RQGSKDSTDGSTNSNS-----------------------SDGTFVFPTTRLGPESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPPMGF--------------T--STGDVHI-------- ---------GIVDRGG-QLEVEVNQ---------------------ARGLTPKPGSKNIP---ATYVKVYVLENGVCLAK KKTKVVKR--NLDPTYQQALLFDESPQ----GKVLQVIVWGDYG-RMD-------------------KCFMGMAQILLED LDLSATVSGWYKLFPT--S---------------------SLADPSIGPLTRRLSQSS-------LES------------ -------------------------------------------------ATSP----SC------------------S-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Gasterosteus_aculeatus_RIMS3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MGGLSGLSAAAARNVVRSSSISGAMYG-L----EKSPGGGGP---DSASLAGN KKRRSSLGAKMVAIVGLSQWSKSTQQ------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------LHQQDGGTKKLRSTIRRSTE-------------TGIAVEMRNRVT---- ----RQGSKDSTDGSTNSNS-----------------------SDGTFVFPTTRLGPESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPSM---------------------GDVNV-------- ---------GMVDRGG-QLEVEVNQ---------------------ARGLTAKPGSKNMP---ATYVKVYVLENGLCLAK KKTRVVKK--NLDPTYQQALLFDESPL----GKVLQVIVWGDYG-RMDH------------------KCFMGMAQILLED LDLSATVSGWYKLFPT--S---------------------SLADPSIGPLTRRLSQSS-------LES------------ -------------------------------------------------ATSP----SC------------------T-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Oryzias_latipes_RIMS3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------QIKSKSEVQ---IRRTFWS-L----IN------------------ --------AHYFDVDHFSE------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------KNNGGTKKLRSTIRRSTE-------------TGIAVEMRNRVT---- ----RQGSKDSTDGSTNSNS-----------------------SDGTFVFPTTRLGPESQ-FSDF--------------- -------------------------------------------------------------------------------L DGLGPAQIVGRQT---------------------------LATPSM---------------------GDVHV-------- ---------AMVDRGG-QLEVEVSQ---------------------ARGLTPKPGTRNIP---ATYVKVYVLENGVCLAK KKTKVVKK--TLDPTYQQALLFDESPQ----GKVLQVIVWGDYG-RMDH------------------KCFMGMAQILLED LDLSATVSGWYKLFPT--S---------------------SLADPSIGPLTRRLSQSS-------LES------------ -------------------------------------------------ATSP----S---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Hydra_magnipapillata_RIMS3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MIMSQLST GNDYYPASPPPIDLSHLTEAEKRKIKNVLDRQK----------------------------------------------- -------ELENETAFIQSGIVRELATYQVRYELKSNQAPLSDANMCELCHKNKEFCVNN-YKRYCKFCRSKLCDECS-IQ SGSGKM----------------------VTWSCLICKKKQDLLLKTGRWFHG--------------------------KE HKFPNPAAEIEQLLTVPTQQKKPLS------------------------------------------------------- -----------------------------------------------------------------PKIIKTGYPASSVTK AQLADKN------------------------------------------------------------------------- ------------------------------------------CTKVLDQTNNESTELSNTKKVTFGNKSKSNMLEEQQIK EMFQS------------------------------------------------------LVSHHVHWSRPDDENKILGDI LLS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------IGSNIIKKFPDYCTAFGIKLSMGVSDEHG-------------------LLKTLVKSVVP GSIGD---IIGKIKPGDELLEWN--------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------ELSLVGCSKEEVEDVLANEDSLDLHLLLSRKCHKEKILANIQSVPPS HHSPPSQPMGILKTIDG--------------------------SFDKTDCQNGAVECDSSKSNVVQANQSRGTPILKAN- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----NISGQLQIKLKYEEDTSCLY---------------------VSIIGAQGLNHRQNMQLRNPYVKLYFLPDRSLQSK RRTKTVLR--SLSPTWNQTFMYTLKSQK---------------------------------------------------- ------------FKGRYLEITLWDY-----------------ERSESNEFLGEILISMLEAPLDNLCHWY---------- -------------------------------------------------PLQLHDQQNML-----------------PQP TPTPTLS----------------------------------PQCSKAQFILQDNGEREHPVENQTVSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------FSPADINEKINEVG----------------------------- TVKTSFSYDSTG-------------------------GTSTDENTPVPSPSPSQVFEMNKELSQITSSKNSDNEKRQ--- --------------YLKPALVQESSVIRPSLLQRAQLFLQKQLDVLTSSSSSETQLTKNSTSLWTSNPTNYESKLTT--- -------------------VTQTENQSPLSSLSVDTSSISSDMS--------TVNNIRYGKEVYGRFSSEKYPQIKRVDS VDSSRKIEPRLTDYNLSLSQQG-------------------------------------------DRAGDKSAEEWR--- ---------------------QSGNDNNYGVKFNNKPTLLRMDS---MSGSSPKN--------------FEKKA------ --------------------------------------------------------------------------ENYYRE QHNYNEDKRFQPRSNHEISFMRSTDFDHNGYSAMRNVNRYRQNSYGSGHSSPVS-------------------------- ---------------------SIGSAKSESSSS--------------------IASSMMTLTSVG-------SSMSWIPP SLRLSGD-VQLIDFVEGLGPAQVVGRQVLGSPLMGDVQLSLLDRRGVLDVEIIRAK-SLIIKPDSKTLPAPYVKVYLLCG KKCVEKRKTKTSSKRTLDPHYAQHLTFVQNYQG---KVLQIMVWGDYGRLD-RKVFMGVCQILLDDLDLSQLVVGWYKLF TTTSLVHPPSNPSPN-------------PSNPTTSSTNSDRF-------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Amphimedon_queenslandica_RIMS3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESKKRVVSNYRSSIIGPPVFQYTSIYAKISEAKNLASGLRDVYCYIKVDNEAIARTASVFNSSEPFW GEEYRLHVPLEYQYVSVYLYDHDTLGVKVPIGKVRLD------------------------------------------- -------------------------------------------------------------------------------- ----------------RDSIMGSPRGLDSWFPLKPISKDDEIQGELLAEIMIDEYSDEMFRGVITLVEARDLAVRDINSK VDPYAVINYKGKELNTPTLK-----------------------KTRFPRWNKTYELPINRPLEEFDNRTVRITIYDSAKF HHDAFLG--------------------------------------------------------------EVIIDLAELFL GQRYKTWYRLQQQDK-------------------------ETSAAMPSGGAKKDGKKEKDLGSLRLKVQCHEER------ ------ILDSQLYSPFVQLMISAVESPGPEG--------------SPLLIMLEEVMTMDRNSLAQTLVRFYIAHNAILPL FDCLISREVENVSLSNVTTLFRGNSLASKCLDQFMKVVALPYLHETLKP---------------VIDTIFNDKKLVELDP DQLKTRSSSTSKLIDTSVAQLTG-----------------YIQIATESIFESVERCPQVLRQSMRLLWDR---------- -------------------------------------------------VIVKFPDGDTP----------------YSSV TGFIFLRFFVPAILSPKLFALREEHADQRAERTLKLTAKLIQTMGNLQTAVDAKEQFMSPMATLLKEGVDKVKTYIN--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------QLIDVQIVMNTPSATPVEVLSDGLG- ---------YLQHVVLNSGVLWKR-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------VTSGTSGAVGSLLYRKRFFELTNIAFTYFPTEKKTGEAKSYPVQWIRVVEKLDEAAFS RKHMFQIVIVPVGPSTAFSPSETVLYLQAADVNEQNRWVSAIRKACLCNREMSPVHHTGVYLPRKKEWSCCRATAPAEPG CCPCHRGITIGDWRDPLDPYLDAQVLYSQYQQGRETLTKNYSAPAESENPENPDVPPPRPAKPGSDEARMQAAYGRLAEV LDELSYHHSQVPNV------------------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------- >Homo_sapiens_RIMS2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MSAPV GPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQS----------------------------- VLK-------------KLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRV SLRSNK----------------------VMWVCNLCRKQQEILTKSGAWFYNSG----SNTPQQPDQKVLRGLRNEEAPQ EKKPKLHEQTQ--FQGPSGDLSVPAVEKSRSHGLT-RQHSIKNGSGVKHHIASDIAS----DRKRSPSVSRDQNRRYDQR EEREEYS-QYATSDTAMPRSPSDYAD---RRSQHEPQFYEDSDH--LSYRDSNRRSHRHSKEYIVDDEDVESR-DEYERQ R------------------------------------------------------------------------------- ----------------------------------------------------REEEYQSRYRSDPNLARYPVKPQPYEEQ MRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTR-EAQGPSSYAQRTTNH SPPTPRRSPLPIDRP-DLRR------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------TDSLR-KQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPP-PKPHKSKKGGKM---RQIS-LSS SEEELASTPEYTSCDDVEIESESVSEK--GD------------------------------------------------- ----------------------------------------------------------------------------MDYN WLDHTSWHS-----------SEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRL CAFITKVKKGSLADTVGHLR----------------------PGDEVLEWNGRLLQGATF-EEVYN-IILESKPEPQVEL VVSRPIG------------------------------------------------------------DIPRIPDSTHAQL ESSSSS--FESQK---------------------------MDRPSISVTSPMSPGMLRDVPQF--LSGQLSSQSLSRRTT PFVPRVQIKLWFDKVGHQLIVTILG---------------------AKDLPSREDGRP-R---NPYVKIYFLPDRSDKNK RRTKTVKK--TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEE------------------SEFLGEILIELET ALLDDEPH-WYKLQTHDVS---------------------SLPLPHPSPYMPRRQLHG-ESPTRRLQRSK---------- -----------------------------------------------RISDSEVSDYDC------------------DDG IGVVS----DYRHDGRDLQSSTLSVPEQVM-SSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMT--- ----------GHYNTISRMDR----------------------------------------------------------- -------------------------------------------------------------------------------- ---------------HRVMDDHYSPDRD---------------------------------------------------- ------------------------------------RDCEAADRQPYH-RSRSTEQRP---LLERTTT------------ --RSRSTERP-DTNLMRS-MP-----------------------------SLMTGRSAPP--------------SPALSR ------------------------------------------------------SHPRTGSVQTSPSSTPVAGRRGR--- ---------QLPQLPPKGTLDR---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------KAGGKKLRSTVQRSTETGLA---VEMRNWMTRQA-SRESTDGSMNSYSSEGN----LIF PGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRAR-GLVVKPGSKTLPAPYVKVYLLDN GVCIAKKKTKVA-RKTLEPLYQQLLSFEESPQG-KVLQ--IIVWGDYGRMD-HKSFMGVAQILLDELELSNMVIGWFKLF PPSSLVDPTLAPLTR------------RASQSSLESSTGPSYSRS----------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Pan_troglodytes_RIMS2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------MQFETLRQ----------------------------------------------------- -------------------------------VCNSVLS------------------------------------------ ------HFHGV--FSSPP--------------------NILQN-----ELFGQTLNNA----RKRSPSVSRDQNRRYDQR EEREEYS-QYATSDTAMPRSPSDYAD---RRSQHEPQFYEDSDH--LSYRDSNRRSHRHSKEYIVDDE-DVESRDEYERQ R------------------------------------------------------------------------------- ----------------------------------------------------REEEYQSRYRSDPNLARYPVKPQPYEEQ MRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTR-EAQGPSSYAQRTTNH SPPTPRRSPLPIDRP-DLRR------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------TDSLR-KQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPP-PKPHKSKKGGKM---RQVS-LSS SEEELASTPEYTSCDDVEIESESVSEKGD--------------------------------------------------- ----------------------------------------------------------------------------MDYN WLD-----------HTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRL CAFITKVKKGSLADTVGHLR----------------------PGDEVLEWNGRLLQGATF-EEVYN-IILESKPEPQVEL VVSRPIG------------------------------------------------------------DIPRIPDSTHAQL ESSSSS--FESQK---------------------------MDRPSISVTSPMSPGMLRDVPQF--LSGQLS--------- -------IKLWFDKVGHQLIVTILG---------------------AKDLPSREDGRP-R---NPYVKIYFLPDRSDKNK RRTKTVKK--TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEE------------------SEFLGEILIELET ALLDDEPH-WYKLQTHDVS---------------------SLPLPHPSPYMPRRQLHG-ESPTRRLQRSK---------- -----------------------------------------------RISDSEVSDYDC------------------DDG IGVVS----DYRHDGRDLQSSTLSVPEQVM-SSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTTT--- ----------GHYNTISRMDRHRVMDDHY--------------------------------------------------- -------------------------------------------------------------------------------S PDRDSHFLTLPRSRYSQTIDHHHRDGRD---------------------------------------------------- --------------------------------------CEAADRQPYH-RSRSTEQRP---LLERTTT------------ --RSRSTERP-DTNLMRS-MP-----------------------------SLMTGRSAPP--------------SPALSR ------------------------------------------------------SHPRTGSVQTSPSSTPVAGRRGR--- ---------QLPQLPPKG-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------TLDR---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Mus_musculus_RIMS2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MSAPL GPRGRPAPTPAASQPPPQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLK-------------------------- ----------------KLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRV SLRSNKV----------------------MWVCNLCRKQQEILTKSGAWFYNSG----SNTLQQPDQKVPRGLRNEEAPQ EKKAKLHEQPQ--FQGAPGDLSVPAVEKGRAHGLT-RQDTIKNGSGVKHQIASDMPS----DRKRSPSVSRDQNRRYEQS EEREDYS-QYVPSDGTMPRSPSDYAD---RRSQREPQFYEEPGH--LNYRDSNRRGHRHSKEYIVDDEDVESR-DEYERQ R------------------------------------------------------------------------------- ----------------------------------------------------REEEYQARYRSDPNLARYPVKPQPYEEQ MRIHAEVSRARHERRHSDVSLANAELEDSRISLLRMDRPSRQRSVSERRAAMENQRSYSMERTR-EAQGQSSYPQRTSNH SPPTPRRSPIPLDRP-DMRR------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------ADSLR-KQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPP-PRPHKSKKGGKM---RQVS-LSS SEEELASTPEYTSCDDVELESESVSEK--GDSQKGKR------------------------------------------- ----------------------------------------------KTSEQGVLSDSNTRSERQKKRMYYGGHSLEEDLE WSEPQIKDSGVDTCSSTTLNEEHSHSDKHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRL CAFITKVKKGSLADTVGHLR----------------------PGDEVLEWNGRLLQGATF-EEVYN-IILESKPEPQVEL VVSRPIG------------------------------------------------------------DIPRIPDSTHAQL ESSSSS--FESQK---------------------------MDRPSISVTSPMSPGMLRDVPQF--LSGQLS--------- -------IKLWFDKVGHQLIVTILG---------------------AKDLPSREDGRP-R---NPYVKIYFLPDRSDKNK RRTKTVKK--TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEE------------------SEFLGEILIELET ALLDDEPH-WYKLQTHDVS---------------------SLPLPRPSPYLPRRQLHG-ESPTRRLQRSK---------- -----------------------------------------------RISDSEVSDYDC------------------EDG VGVVS----DYRHNGRDLQSSTLSVPEQVM-SSNHCSPSGSPHRVDVIGRTRSWSPSAPPPQ-RNVEQGHRGTR-AT--- ----------GHYNTISRMDR----------------------------------------------------------- -------------------------------------------------------------------------------- ---------------HRVMDDHYSSDRDSHFLTLPRSRHSQTIDHHHRDG------------------------------ ------------------------------------RDCEAADRQPYH-RSRSTEQRP---LLERTTT------------ --RSRSSERP-DTNLMRS-MP-----------------------------SLMTGRSAPP--------------SPALSR ------------------------------------------------------SHPRTGSVQTSPSSTPGTGRRGR--- ---------QLPQLPPKGTLERS----------------------AMDIEERNRQMKLNKYKQVAGSDPRLEQDYHSKYR SGWDPH------------RGADTVSTKSSDSDVSDVSAVSRTSSASRFSSTSYMSVQSERPRGNRKIS------------ ---------------------------------------------------------------------------VFTSK MQNR-------QMGVSGKNLTKSTSISGDMCSLEKNDGSQSDTAVGALGTSGKKRRSSIGAKMVAIVGLSRKSRSASQLS Q-------------------TEGGGKKLRSTVQRSTETGLA---VEMRNWMTRQA-SRESTDGSMNSYSSEGN----LIF PGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRAR-GLVVKPGSKTLPAPYVKVYLLDN GVCIAKKKTKVA-RKTLEPLYQQLLSFEESPQG-RVLQ--IIVWGDYGRMD-HKSFMGVAQILLDELELSNMVIGWFKLF PPSSLVDPTLAPLTR------------RASQSSLESSTGPSYSRS----------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Equus_caballus_RIMS2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------RVKEEHKP----------QPTQWFPFSGITELVN--N VLQPQQKQQNEKEAQTKLHQQFELYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRV SLRSNK----------------------VMWVCNLCRKQQEILTKSGAWFYNSG----SNTPQQPDQKVLRGLRNEEAPQ EKKAKLHEQAQ--FQGPSGDLSVPAVEKSRSHGLT-RQDSIKNGSGVTHQIASDIAS----DRKRSPSVSRDQNRRYDQR EEREEYS-QYATSDSAMPRSPSDYAD---RRSQHEPQFYEESDN--INYRDSNRRSHRHSKEYIADDEDVESR-DEYERQ R------------------------------------------------------------------------------- ----------------------------------------------------REEEYQARYRSDPNLARYPVKPQPYEEQ MRIHAEVSRARHERRHSDVSLANAELEDSRISMLRMERPSRQRSISERRAALENQRSYSMERTR-EAQGPSSYPQRTTNH SPPTPRRSPIPIDRP-DLRR------------------------------------------------------------ -----------------------------------------------------------------------------