>Homo_sapiens_RGS13 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MSRRNCWICKMCRDESKRP------------------------------- ---------------PSNL------------------------------------------------------------- ----------------------TLEEVLQ---WA-QSFENL-MATK---YGPVVYAAYLKMEHSDENI--QFWMACETYK KIA--SRWSRISRAKKLYKIYIQPQSPREIN----IDSSTRETIIRNIQE-PTETC---FEEAQKIVYMHMERDSYPRFL KSEMYQKLLK---------TMQSNNSF----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Macaca_mulatta_RGS13 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MSRRNCWICKVFRDESKRP------------------------------- ---------------PSNL------------------------------------------------------------- ----------------------TLEEVLQ---WA-QSFENL-MATK---YGPVVYAAYLKMEHSDENI--QFWMACETYK KIA--SRWSRTSRAKKLYRIYIQPQSPREIN----IDNSTRQTIIKNIQE-PTETC---FEEAQKIVYMHMERDSYPRFL KSEMYQKLLK---------TMQSNNSF----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Mus_musculus_RGS13 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MSRHICWICKLCRDESKRL------------------------------- ---------------PSNL------------------------------------------------------------- ----------------------TLDEVLK---WA-QSLESL-MATK---YGPIVYTAYLKLEHSDENI--KFWMACETYK KIA--SRRGRISRAKKLYNIYIQPQSPREIN----IDSTTREAIIKSIRE-PTQTC---FEEAQKIVYMHMEMDSYPRFL KSEMYQQLLK---------TVQSQSS------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Rattus_norvegicus_RGS13 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MSRHICWICKLCRHESKRL------------------------------- ---------------PSNL------------------------------------------------------------- ----------------------TLDEVLK---WA-QSLESL-MATK---YGPVVYTAYLKLEHSDENI--KFWMACETYK KIA--SRRGRISRAKKLYNLYIQPQSPREIN----IDSTTREAIIKSIRE-PTQTC---FEEAQKIVYMHMEMDSYPRFL KSEMYQKLLK---------TVQSKSC------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Homo_sapiens_RGS8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------MWNTLTRSLSDHPVGKDPQ-------------------------------- -------------------------------------------------------------------------------- --------------------------AMRTGQRQNKGMRTRLGCLSHKSDSCSDFTAILP-------------------- ---------DKPNRALK--------------------------------------------------------------- --------------------RLSTEEATRWA----DSFDVL-LSHK---YGVAAFRAFLKTEFSEENL--EFWLACEEFK KTR--STAKLVSKAHRIFEEFVDVQAPREVN----IDFQTREATRKNLQE-PSLTC---FDQAQGKVHSLMEKDSYPRFL RSKMYLDLLSQSQRRLS--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Callithrix_jacchus_RGS8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------MWSALTRSLSDHPVGKDPQ-------------------------------- -------------------------------------------------------------------------------- --------------------------AMRTGQRQNKGMRTRLGCLSHKSDSCSDFTAILP-------------------- ---------DKPNRALK--------------------------------------------------------------- --------------------RLSTEEATRWA----DSFDVL-LSHK---YGVAAFRAFLKTEFSEENL--EFWLACEEFK KTR--STAKLVSKAHRIFEEFVDVQAPREVN----IDFQTREATRKNMQE-PSLTC---FDQAQGKVHSLMEKDSYPRFL RSKMYLDLLSQSQRRLS--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Mus_musculus_RGS8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MRTSQRQNKGMRTRLGCLSHKSDSCSDFTAILP-------------------- ---------DKPNRALK--------------------------------------------------------------- --------------------RLSTEEATRWA----ESFDVL-LSHK---YGVAAFRAFLKTEFSEENL--EFWLACEEFK KTR--STAKLVTKAHRIFEEFVDVQAPREVN----IDFQTREATRKNMQE-PSLTC---FDQAQGKVHSLMEKDSYPRFL RSKMYLDLLSQSQRRLS--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Gallus_gallus_RGS8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------M-------------------------------- -------------------------------------------------------------------------------- --------------------------AALLIPRRNRGMRTRLGCLSHKSDSYNDFTAILP-------------------- ---------DKPNRALK--------------------------------------------------------------- --------------------RLSTEEATRWA----DSFDVL-LSHK---YGLAAFRAFLKTEFSEENL--EFWLACEDFK KTR--STAKLAAKAQRIFEEFIDVQAPREVN----IDFQTRELTRRNMQE-PSLSC---FDQAQGKVHSLMEKDSYPRFL RSKIYTDLLSQTQRRLS--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Anolis_carolinensis_RGS8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MKEDAPRCSDQSLCDHTLGKELQ-------------------------------- -------------------------------------------------------------------------------- --------------------------STRTGQRQNRGMRTRLGCLSHKSDSCSDFTAILP-------------------- ---------DKPNRALK--------------------------------------------------------------- --------------------RLSTEEATRWG----DSFDVL-LSHK---YGVAAFRAFLKTEFSEENL--EFWLACEEFK KTR--STAKLASKAQRIFEEFVDVQAPREVN----IDFQTREVTRRNIQE-PSSSC---FDQAQGKIHSLMEKDSYPRFL RSKIYTDLLSQTQRRLS--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Danio_rerio_RGS8_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MKTRLGCLSNKSDSCSDFSEFLPP------------------- -------AQERTTRYL---------------------------------------------------------------- --------------------KLSNDEVTRWA----DSFDIL-LSNK---YGLAAFRTFLKTEFSDENI--EFWLACEDYK KIK--SPAKMMSKANKIYKEFIDVHAPREVN----IDHRTREETKNRLLE-PTPHS---LNEVQAKVYSLMEKDSYPRFI RSKIYQDLLNRTQIYCQRKSV----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Takifugu_rubripes_RGS8_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------SCIVWM-------------------------------- -------------------------------------------------------------------------------- --------------------------PE-----RTPTMKTRLGCLSKKSDSYSDFSEFLPP------------------- -------AHDTTARWLN--------------------------------------------------------------- --------------------RLSTDEVVRWS----ESFDHL-LSHK---HGLAAFRTFLKSEFSDENI--EFWMACEEYK KTK--SSTKLVSKANKIYQEFLDIQAPREVN----IDHRTREKTKQSLED-PSPTS---LNEVQAKVYSLMERDSYPRFL RSKMYKDLVSRAHARGQ--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Tetraodon_nigroviridis_RGS8_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------M-------------------------------- -------------------------------------------------------------------------------- --------------------------HSLYDPKQDPTMKTRLGCLSKKSDSYSDFSEFLPP------------------- -------AHETTARCLN--------------------------------------------------------------- --------------------RLSTDEVVRWS----ESFEHL-LSHK---HGLAAFRTFLKSEFSDENI--EFWMACEEYK KTK--SSTKLVSKANKIYKEFIDTQAPREVN----IDHRTREKTKQSLED-PSPTS---LNEVQAKIYSLMERDSYPRFL RSKMYQDMVSRAHAQGQRRSV----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Gasterosteus_aculeatus_RGS8_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MKTRLGCLSNKSDSYSDFSEFLPP------------------- -------AHETTARCL---------------------------------------------------------------- --------------------KVSTDEVVRWS----ESFDHL-LSHK---YGLAAFRTFLKSEFSDENI--EFWMACEEYK KIK--SSTKLVSKANKIFQEFIDIQAPREVN----IDYRTREKTKQSLED-PSPTS---LNEVQGKVYGLMEKDSYPRFL RSKMYQDMVNRANAHGQRRSV----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Oryzias_latipes_RGS8_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------L-------------------------------- -------------------------------------------------------------------------------- --------------------------AALLQFGRLSTMKTRLGCLSKKSDSYSDFSEFLPP------------------- -------AHETTARCLNTSH------------------------------------------------------------ ------AVTSEQLKQTF---RLSTDEVVRWS----DSFEHL-LSHK---YGLAAFRTFLKSEFSDENI--EFWMACEEYK KIK--SSTKLLSKANKIFKEFIEVQSPREVN----IDYRTREKTKQSLAD-PTPTS---LNEVQGKIYSLMEKDSYPRFL RSKMYQDMINRAHAQGQRRSV----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Homo_sapiens_RGS1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------MRAAAISTP------- ----------------KLDKMPGMFFSAN---PKELK-GTTHSLLD---------------------------------- -------------------------------------------------------------------------------- -----------------------DKMQKRRPKTFGMDMKAYLRSMIPHLES----------------------------- -------GMKSSKSKD-VL------------------------------------------------------------- ----------------------SAAEVMQ---WS-QSLEKL-LANQ---TGQNVFGSFLKSEFSEENI--EFWLACEDYK KT---ESDLLPCKAEEIYKAFVHSDAAKQIN----IDFRTRESTAKKIKA-PTPTC---FDEAQKVIYTLMEKDSYPRFL KSDIYLNLLN---------DLQANSLK----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Mus_musculus_RGS1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------MRAAAISMP------- ----------------RLNKMPGMFFSAS---PKDSK-EHSHSLLD---------------------------------- -------------------------------------------------------------------------------- -----------------------DKKQKKRPKTFGMDVKTYLRSMIPHLES----------------------------- -------GMKSAKSKD-IL------------------------------------------------------------- ----------------------SAEEVMQ---WS-QSLEKL-LANQ---TGQNVFGRFLKSEFSEENI--EFWLACEDYK KT---ETDLLHNKAENIYKAFVHSDAVKQIN----IDFHTRESTAKKIKT-PTPTS---FDEAQKVIYSLMEKDSYPRFL KSNIYLNLLN---------DLQANTLK----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Monodelphis_domestica_RGS1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------MRAAAISTP------- ----------------RLNKMPGIFFSSAN--TNELK-GSDHLLLD---------------------------------- -------------------------------------------------------------------------------- -----------------------DKTQKKKPKAFGTDLKAYLKSMLPHLES----------------------------- -------GIKSSKSKD-IL------------------------------------------------------------- ----------------------SVTEVIQ---WS-QSLEKL-LTNQ---TGLAVFGNFLKSEFSEENI--EFWLACEDYK RT---ESDHLHCKAEKIYKAFVQSDATKQIN----IDFHTRESTAKKIQV-PTPTS---FDEAQKVIYTLMERDSYPRFL KSEVYLKLLS---------ELQGNSLK----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Xenopus_tropicalis_RGS1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------AADINVN------- ----------------ALYKMPGIFFSHAN----ALK--EVDNKPD---------------------------------- -------------------------------------------------------------------------------- -----------------------EVMAQKK-KNFAVDLKNYLKSMLPHLETM-----KSSS------------------- -------STSSSDSEKNKL------------------------------------------------------------- ----------------------TPDEIIQ---WT-MSLEKL-LISE---DGQSVFREFLKSEFSEENI--EFWLACEDYK ATN--DSEELRCKANVIYQEFIQPNANKQIN----IDFSTRNSVTKDLLE-PTITT---FNDAQKMIFILMERDSYPRFL KSEIFLRLAE---------RHHGNNVRG---------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Homo_sapiens_RGS18 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------METTLLFFSQINMCESKEKTFFKLIHGSG---------------------------------- -------------------------------------------------------------------------------- -----------------------KEETSKEAKIRAKEKRNRLSLLVQKPE----FHEDTRS------------------- -------SRSGHLAKETRV------------------------------------------------------------- ----------------------SPEEAVK---WG-ESFDKL-LSHR---DGLEAFTRFLKTEFSEENI--EFWIACEDFK KSK--GPQQIHLKAKAIYEKFIQTDAPKEVN----LDFHTKEVITNSITQ-PTLHS---FDAAQSRVYQLMEQDSYTRFL KSDIYLDLMEG--RPQRPTNLRRRSRSFTCNEFQDVQSDVAIWL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Mus_musculus_RGS18 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------MDMSLVFFSQLNMCESKEKTFFKLMHGSG---------------------------------- -------------------------------------------------------------------------------- -----------------------KEETSIEAKIRAKEKRNRLSLLLQRPD----FHGETQA------------------- -------SRSALLAKETRV------------------------------------------------------------- ----------------------SPEEAVK---WA-ESFDKL-LSHR---DGVDAFTRFLKTEFSEENI--EFWVACEDFK KCK--EPQQIILKAKAIYEKFIQNDAPKEVN----IDFHTKEVIAKSIAQ-PTLHS---FDTAQSRVYQLMEHDSYKRFL KSETYLHLIEG--RPQRPTNLRRRSRSFTYNDFQDVKSDVAIWL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Gallus_gallus_RGS18 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------MENPLLLFPQLNISASKDKSYYKVMKPTV---------------------------------- -------------------------------------------------------------------------------- -----------------------KEEPNKASKPGAKQKRNRLSLLLQKSE----LHEAEHL------------------- -------GKPTNLTKAPSV------------------------------------------------------------- ----------------------SPEEAMK---WG-ESFDKL-LSQK---DGLDAFTRFLKTEFSEENI--EFWIACEDYK KSK--TTNELFPKAKTIYEMFIRKDAPKEVN----LDFKTKEVTSQNIEQ-PVITT---FDAAQNTVYRLMEQDSYPRFL RSDLYLNLVKG--RNPGRPTLRRRSRSFTVNDFQGVRPDFTIWQ------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Anolis_carolinensis_RGS18 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------PDVIKK---WG-ESFYNL-ISQK---AGVDTFTQFLRSEFSEENI--EFWMACEDYK KCK--DASQLSLKAQAIYETFIEKEAPKEVN----LDFNTKVCTSENMSH-PTLNT---FDAAQNKIYALMEQDSYPRFL KSDLYLDMVHG--QPRGHSALRRRSRSFTFNEFKDVQPDFAIWM------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Danio_rerio_RGS18_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MRSEDEQLAC------------------------------ -------------------------------------------------------------------------------- ---------------------RMKETHL-----RSKDKKGRLSLLLARSG----SHENVSP------------------- -------DKK-PQAKSNHI------------------------------------------------------------- ----------------------PPDVAMK---WS-DSFEDL-LSHS---DGVEVFTRFLRTEFSEENI--EFWLACEDFK TTE--SSTKLQTKAKQIHAIFIDKEAPKEIN----IDHSTKAAIEKNILQ-PTNSC---FDAAQHKIYGLMKRDCYPRFL ASDIYLTLTKR--SGP-PTMTRRRSRSFVFNERPEG---TAAWL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Takifugu_rubripes_RGS18_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------METLLLLFPQFSFTAQKEEVYFRMLGPGATQAA------------------------------ -------------------------------------------------------------------------------- ---------------------KMKEDSSSHGRQKDKERTSRLSLFLAKSG----SHENVSP------------------- -------HKT-TNSTANNV------------------------------------------------------------- ----------------------SPELALR---WS-DSFEEL-LSHS---DGVEVFSQFLRKEFSKENI--EFWLACEEFK TID--SRTKMLSKAKYIYTVFCETDSPKEIN----IDYNTRMAIQRSMAK-PTKGC---FEAAQQQVYNLMKKDSYPRFL LSDTYLNLTRR--RGPGATMFRRRSRSCVFNERGEAAAEPSAW------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Tetraodon_nigroviridis_RGS18_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------METLLLLFPQFSYTTQKQEAYCRMLAPGASRAL------------------------------ -------------------------------------------------------------------------------- ---------------------KMKEDSS---GQKDKERKSRLSLFLTKSG----SHENVSP------------------- -------HKK-KNAPANNV------------------------------------------------------------- ----------------------SPESALQ---WS-DSFEEL-LSHS---DGVEVFSQFLRKEFSEENI--EFWLACEEYK TID--SETKLLSKAKYIYTVFCEPDSPKEIN----IDYNTRMAIQRGVAK-PTKGC---FEAAQLQVYNLMKKDSYPRFL LSDTYLRLTGR--RGPRANMFRRRSRSCVFDERGEAAAERSAW------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Gasterosteus_aculeatus_RGS18_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------MKDDSS---RQKDKERKSRLSLFLTKSG----SHENVSP------------------- -------TKK-TNTT-TNI------------------------------------------------------------- ----------------------SPETALQ---WS-DSFEEL-LKHS---DGVESFSQFLRTEFSEENI--EFWLACEEYK TID--SDTKLLSKAKCIYTVYIDSDAPKEIN----IDYNTKAAIQKVIAK-PTKSC---FEAAQLIVYSLMKKDSYPRFL HSDIYLRLTRR--KGPGTNMFRRRSRSCVFNDRGEATTEPSAW------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Oryzias_latipes_RGS18_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------METLLFLFPQFTYMAPKEEAYFKMLGAEDAQAA------------------------------ -------------------------------------------------------------------------------- ---------------------KMKDDSS---RQNEKERKSRFSLFLTKSG----SHENISP------------------- -------QKK-TNTTLSNI------------------------------------------------------------- ----------------------SPETALQ---WS-DSFEDL-LKHP---DGVEAFTQFLRTEFSEENI--EFWLVCEEYK SID--SKSKLLSKAKYIYTVFIESEAPKEVN----IDYNTKMAIKANMSH-PTRST---FEAAQMKVYSLMKKDCYPRFL HCDIYLRLTRR--KGPGATMFRRRSRSCVFNERGEP-TQPSAW------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Homo_sapiens_RGS16 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MCR-TLAA----------------------------------- -------------------------------------------------------------------------------- --------------------------FPTTCLERAKEFKTRLGIFLHKSELGCD--TGSTG------------------- -------KFEWGSKHSKEN------------------------------------------------------------- --------------------RNFSEDVLGWR----ESFDLL-LSSK---NGVAAFHAFLKTEFSEENL--EFWLACEEFK KIR--SATKLASRAHQIFEEFICSEAPKEV----NIDHETHELTRMNLQT-ATATC---FDAAQGKTRTLMEKDSYPRFL KSPAYRDLAAQASAASATLS--SCSLDEPSHT------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Pan_troglodytes_RGS16 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MCR-TLAA----------------------------------- -------------------------------------------------------------------------------- --------------------------FPTTCLERAKEFKTRLGIFLHKSELGCD--TGSTG------------------- -------KFEWGSKHSKEN------------------------------------------------------------- --------------------RNFSEDVLGWR----ESFDLL-LSSK---NGVAAFHAFLKTEFSEENL--EFWLACEEFK KIR--SATKLASRAHQIFEEFICSEAPKEV----NIDHETRELTRMNLQT-ATATC---FDAAQGKTRTLMEKDSYPRFL KSPAYRDLAAQASAASATLS--SCSLAEPSHT------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Mus_musculus_RGS16 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MCR-TLAT----------------------------------- -------------------------------------------------------------------------------- --------------------------FPNTCLERAKEFKTRLGIFLHKSELSSD--TGGIS------------------- -------KFEWASKHNKE-------------------------------------------------------------- --------------------RSFSEDVLGWR----ESFDLL-LNSK---NGVAAFHAFLKTEFSEENL--EFWLACEEFK KIR--SATKLASRAHHIFDEYIRSEAPKEV----NIDHETRELTKTNLQA-ATTSC---FDVAQGKTRTLMEKDSYPRFL KSPAYRDLAAQASATSTSAP--SGSPAEPSHT------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------ >Canis_familiaris_RGS16 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MCR-TLAA----------------------------------- -------------------------------------------------------------------------------- --------------------------FPTTCLERAKEFKTRLGIFLHKSELGSD--TGNVG------------------- -------KFEWSSKHSKDG------------------------------------------------------------- --------------------RNFSEDVLGWK----ESFDSL-LSSK---NGVAAFHAFLKTEFSEENL--EFWLACEEFK KLR--SAAKLASRAHKIFEEFIRSEAPKEV----NIDHETRELTEKNLQA-ATATC---FDVAQGKIRTLMEKDSYPRFL KSPAYRDLAAQASAASASQS--GCSPAEPLHT------------------------------------------------ -------------------------------------