>Homo_sapiens_KCNQ4 -------------------------------------------------------------------------------- ------------------------------------------------------MAEAPPRRLGLGPPPG----DAPRAE LVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACG-QRSSAAHKRYRRLQNWVYNVLERPRGWAFVY H-VFI--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L LILEFVMIVVFGLEYIVR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVIDFIVFVASVA VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDMSRAYLTAT WYYYDSILPSFR---------ELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTS----FCPGE-- -------------------------SSRMGIKDRIRMGSSQR-RTGPSKQHLAPPT------------------------ --MPTSPSSEQ---------------------------------------------------------VGEATSPTKVQK SWS--FNDRTRFRASLRLKPRTSAE---------------------DAPSEEVAE-----------------EKSYQCEL TVDDIMPAVKTVIRSIRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR-------------- ----------------------VDQIVGRGPGDR---KA-----------------------------------REKGDK GPS--------------------DA-EVVDEISMMG----------------------------------RVVKVEK-QV QSIEHKLDL--LLGFYSRCLRSG--TSASLGAVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR----------- ----------SVSTNMD--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Pan_troglodytes_KCNQ4 -------------------------------------------------------------------------------- ------------------------------------------------------MAEAPPRRLGLGPPPG----DAPRAE LVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACG-QRSSAAHKRYRRLQNWVYNVLERPRGWAFVY H-VFI--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L LILEFVMIVVFGLEYIVR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVIDFIVFVASVA VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDMSRAYLTAT WYYYDSILPSFR---------ELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTS----FCPGE-- -------------------------SSRMGIKDRIRMGSSQR-RTGPSKQHLAPPT------------------------ --MPTSPSSEQ---------------------------------------------------------VGEATSPTKVQK SWS--FNDRTRFRASLRLKPRTSAE---------------------DAPSEEVAE-----------------EKSYQCEL TVDDIMPAVKTVIRSVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR-------------- ----------------------VDQIVGRGPGDR---KA-----------------------------------REKGDK GPS--------------------DA-EVVDEISMMG----------------------------------RVVKVEK-QV QSIEHKLDL--LLGFYSRCLRSG--TSASLGAVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR----------- ----------SVSTNMD--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Gorilla_gorilla_KCNQ4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L LILEFVMIVVFGLEYIVR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVI---------- ----------GNEX-----EELRKKSELGLRE-------------------------MGDLYPFP-VWKSPTSPRQAQRS ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDMSRAYLTAT WYYYDSILPSFR---------ELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTS----FCPGE-- -------------------------SSRMGIKDRIRMGSSQR-RTGPSKQHLAPPT------------------------ --MPTSPSSEQ---------------------------------------------------------VGEATSPTKVQK SWS--FNDRTRFRASLRLKPRTSAE---------------------DAPSEEVAE-----------------EKSYQCEL TVDDVMPAVKTVIRSVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR-------------- ----------------------VDQIVGRGPGDR---KA-----------------------------------REKGDK GPS--------------------DA-EVVDEISMMG----------------------------------RVVKVEK-QV QSIEHKLDL--LLGFYSRCLRSG--TSASLGAVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR----------- ----------SVSTNMD--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Mus_musculus_KCNQ4 -------------------------------------------------------------------------------- ------------------------------------------------------MAEAPPRRLGLGPPPG----DAPRAE LVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGGQRSSAAQKRYRRLQNWVYNVLERPRGWAFVY H-VFI--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L LILEFVMIVVFGLEYIIR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVIDFIVFVASVA VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDTSRAYLTAT WYYYDSILPSFR---------ELALLFEHIQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSAS----FCPGE-- -------------------------SSRMGIKDRIRISSSQK-RTGPSKQHLAPPP------------------------ --IPTSPSSEQ---------------------------------------------------------VGEASSPSKVQK SWS--FNDRTRFRASLRLKPRCSAE---------------------EGPSEEVAE-----------------EKSYQCEL TVDDVMPAVKTVIRSVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQAR-------------- ----------------------VDQIVGRGPGDR---KT-----------------------------------REKGDK GPS--------------------DT-EAVDEISMMG----------------------------------RVVKVEK-QV QSIEHKLDL--LLGFYSRCLRSG--TSASLGTVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR----------- ----------SVSTNMD--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Dasypus_novemcinctus_KCNQ4 -------------------------------------------------------------------------------- ------------------------------------------------------MAEAPPRRLGLAPPPG----DAPRAE LVALTAVQSEQGEAGGGGSPRRHGLLGSPLPPGAPLPGPGSGSGSACG-QRSSAAHKRYRRLQNWVYNVLERPRGWAFVY H-VFI--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L LILEFVMIVVFGLEYIVR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVIDFIVFVASVA VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDTSRAYLTAT WYYYDSILPSFR---------ELALLFEHVQRARNGGLRPLEVRRVPVPDGAPSRYPPVATCHRPGSTS----FCPGE-- -------------------------SSRMGIKDRIRMGSSQR-RTGPSKQHLAPPP------------------------ --IPTSPSSEQ---------------------------------------------------------MGEATSPTKVQK SWS--FNDRTRFRASLRLKPRTSAE---------------------EGPSEDVAE-----------------EKSYQCEL TVDDVMPAVKTVIRSVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQAR-------------- ----------------------VDQIVGRGTGDR---KA-----------------------------------REKGDK GPS--------------------DP-EAVDEISMMG----------------------------------RVVKVEK-QV QSIEHKLDL--LLGFYSRCLRSG--TSASLGTVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR----------- ----------SVSTNMD--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Xenopus_tropicalis_KCNQ4 -------------------------------------------------------------------------------- --------------------------------------------------MAVGTQPQADNGRVPSLSLAPISGQESGME FVALTAVQTDSGNPR---------RLGLLGTPIPGAP-------------RSSSSHKKYRRLQNYLYNVLERPRGWAFIY H-AFI--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FFLVFSCLVLSVFSTIP---EYHHLANKG----------------------------------------------L FILEFVMIVVFGMEYVIR-----------------IWSAGCCCRY-RGWKGRLRFARKPF-------CVIDFIVLVASLA VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NKEFSTYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRT---PAANLIQA-AWRLYSTDVSRSYLTAT WYYYDSILPSFR---------ELLLLFDTWHRTCS---RNGGVRLCQG--SPRYQPVPSTPKP----ATPP--FCTGE-- -------------------------SSKLGLKDRMRGTVAPK-QTTRSKQYLAPP------------------------- --ERASPGTEP---------------------------------------------------------AAETPSPTKVQK SWS--FNDRTRFRASLRLKSRPQAD---------------------EGPGDDIND-----------------EKRLPNDL TMEDVMPTIKTLIRAFRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQGR-------------- ----------------------VDQIIGRGPVPVEKKP------------------------------------RDKGEK VSTMG------------------PEVEAADELSMMG----------------------------------RVVKVER-QV QSIEDKLDI--LLGFYSQCIRKGPASSFTLTSMQMPLIDQEMTSDYQSPVDPVDFS---VSAQTLNISH----------- ----------SASTNME--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Takifugu_rubripes_KCNQ4_a -------------------------------------------------------------------------------- ------------------------------------------------------MLGSPSNNGGIRMLAPPAPDDDRRVE FVALTAVHTERSEPSTPERGHPSHRTGLLGTPLPGPPGP---------RANTSASSKRFRKLQNFLYNVLERPRGFAFIY H-AFN--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVFSTIH---EHQKFANQDSS------------------------------------------SWW LLHEFVMIVVFGLEYFIR-----------------IWAAGCCCRY-RGWQGRLRFARKPF-------CVIDLIVFVPSLA VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----VLIFASFFVYLVEKDV----------------NTDFNTYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPRTWQGRLLAAGFALLGVSFFA----LPAG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDASHSYLTAT WYFYDSMLPSFR---------ELTLLFSHLQRQRNKQLLPLHDTYAQIHAGRKQRYPRLRACARGSADCFV--PSRGE-- -------------------------GSKIGFRDRIRMNNSRSSQTIRSKASPLPPGSN---------------------- --VRRSPSQEN---------------------------------------------------------VPDPTSPGKVQK SWS--FNDRTRFRTSLRLKPRPPADV--------------------EGVGEDSTE-----------------DKP-YCDM AMEEVIPAVKTLIRAVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR-------------- ----------------------VDQIIGRGAVQPDKKAR-----------------------------------PEKGEK TP---------------------PELDSLDELSMMG----------------------------------RVVKVEK-QV QSIENKLDL--LLNLYSHCLKKGSSN-YTLSTL----LDPDLTSDYHSPTDQRDLF---PSANTLNIST----------- ----------SESGNLE--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Tetraodon_nigroviridis_KCNQ4_a -------------------------------------------------------------------------------- ------------------------------------------------------MLGSPSNNGGIRMLAPPAPDDERRVE FVALTAVHTERSEPSTPERGHPSHRTGLLGTPLPGPPGP---------RASASASSKRFRKLQNFLYNVLERPRGFAFIY H-AFI--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVFSTIP---EHQKFANQG----------------------------------------------L FILEFVMIVVFGLEYFIR-----------------IWAAGCCCRY-RGWQGRLRFARKPF-------CVIDLIVFVASLA VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----VLIFASFLVYLAEKDI----------------NTDFSTYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPRTWQGRLLAAGFALLGVSFFA----LPAG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDASHSYLTAT WYFYDSMLPSFR---------ELTLLFSHLQRRTPGALWSIETSHLTPPPCSQERVPDLKPCP---PRFHS--FFFAV-- -------------------------SSKIGFRDRIRMNNSRSSQTIRSKASPLPPGSN---------------------- --GRRSPSQEN---------------------------------------------------------MADSTSPGKVQK SWS--FNDRTRFRTSLRLKPRPPADA--------------------EGVGEDSVE-----------------DKP-YCDV AMEEVIPAVKTLIRAVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR-------------- ----------------------VDQIIGRGAVQPDKKVR-----------------------------------PEKGEK TP---------------------PELDSLDELSMMG----------------------------------RVVKVEKQQV QSIENKLDL--LLDLYSHCLKKGSSN-FTLSTL----LDPDLTSDYHSPTDQRDLF---PSANTLNIST----------- ----------SESGNLE--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Gasterosteus_aculeatus_KCNQ4_a -------------------------------------------------------------------------------- ------------------------------------------------------MPESPSNNGGARMLAPPTSSDDRRVE FVALTAVHTERSEPSSPERGHPSNRTGLLGTPHTSASNK---------RYRKLQN---------CLYNVLERPRGWAFIY H-AFI--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVFSTIP---DHQRFANQG----------------------------------------------L FILEFVMIVVFGLEYFIR-----------------IWAAGCCCRY-RGWQGRLRFARKPF-------CVIDFIVFVASLA VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----VLIFASFLVYLAEKDI----------------NSDFNTYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPRTWQGRLLAAGFALLGVSFFCPCLLTPQG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDAKHSYLTAT WYFYDSMLPSFSARGGVR---ELTLLFSHLQRQRNTKKVLPSSYHTLLSGLRPYSLPYLS----------------GD-- -------------------------SSKMGFRDRIRMNNSRSSQTIRSKGSPLPPSSG---------------------- --VRGSPSQEN---------------------------------------------------------VPEAISPGKVQK SWS--FNDRTRFRTSLRLKTRPPVDGS------------------VEGVGEDSVE-----------------DKP-YCDV SMEEVIPAVKTLIRAVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQMR-------------- ----------------------VDQIIGRGAVQPDKKAR-----------------------------------TEKGEK TP---------------------PELDPLDELSMMG----------------------------------RVVKVEK-QV QSIENKLDL--LLSFYSQCLKKGSSH-FTLSSL----LDPELTSDYHSPTDQRDLF---PSANTLNIS------------ -----------ESGNLE--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Oryzias_latipes_KCNQ4_a -------------------------------------------------------------------------------- ----------------------------------------------------------------------PGPNDDRRVE FVALTAVQTERSEPSTPERGPPSHRTGLLGTPLPGPPGP---------RASASASSKRFRKLQNFLYNVLERPRGWAFIY H-AFM--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----WEVRMSSVLF------------------L----------------------------------------------C ALQEFVMIVVFGMEYFIR-----------------IWAAGCCCRY-RGWQGRLRFARKPF-------CVIDFIVFVASLA VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----VLIFASFLVYLAEKDI----------------NSDFGTYADSLWWGT------------------ -------------------------------ITLTTIGYGDKTPRTWQGRLLAAGFALLGVSFFA----LPAG--ILGS- -------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDAKHSYLTAT WYFYDSMLPSF------R---ELTLLFSHLQRQRSTKKVLQNSYHTLLSGLRPNSSPYLS----------------GD-- -------------------------SSKMGFRDRIRMNNSRSSQAIRNKASPLPPGSG---------------------- --VRRSPSQEN---------------------------------------------------------IPEATSPGKVQK SWS--FNDRTRFRTSLRLKPRPPVDA--------------------EGLGEDSVE-----------------DKP-YCDV AMDEVIPAVKTLIRAVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQMR-------------- ----------------------VDLIIGRGPVQPDKKTR-----------------------------------PEKGEK TP---------------------PDLDPLDELSMMG----------------------------------RVVKVEK-QV QSIEGKLDL--LLSFYSQCIKKGSSH-VTLSSL----LDPDLTSDYHSPTDHRDLF---PSANTLNISR----------- ----------SESDNLE--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Apis_mellifera_KCNQ4 -------------------------------------------------------------------------------- ---------------MKDRPHRPYRDHHGQAMPLEEVQGLLLPPSRTGNRGPLTIVQVGKGNGGGGDGGSDLLKLEPPSD LRPTPSPLSETSATLQSDNNDTFSGGVDPRLLLGANTGGDRNTWEGRYRVKEHRRAGKATFQGQVYNFLE-RPTGWKCFL YHFSV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FMVVLVCLIFSVLSTIE---QYSNFANET----------------------------------------------L FWMEICLVVFFGVEYLVR-----------------LWSAGCRSKY-MGCCGRLRFIRKPI-------CIIDLIVVVASMV VL------SVGSNGQVFATSAIRGIRFLQILR-------------------------MLHVDRQGGTWRLLGSVVFIHRQ ELITTLYIGFL----GLIFSSYFVYLAEKDV----IGPDG-------KTDFSSYADALWWGV------------------ -------------------------------ITVTTIGYGDTVPQTWMGKIVASCFSVFAISFFA----LPA--GILGS- -------------------------------GFALKVQQKQRQKHFNRQIP---AAAMLIQC-LWRCYAADK-AINSVAT WNIYIKDPAP--------------------------------AGQPSTPLGKLI-------------------------- --------------------CVKKMSLMIQVAKK-ASVLKRRKSRNRMDVQQQQQ------------------------- --QSLPPVTIS--------------GGMSSGGATGDQN---------------------------DNQRMENEGDVIFYM EEPK-AGTPNRARRDNRGS------LFTS-----------QTSSVTEATSDEIDIDI--------------E-----EPQ RVTTLTEAHRNAIRAIRKIKYFVA-----RRKFQQARKPYDVRDVIEQYSQGHLNMMVRIKELQRR-------------- ----------------------LDQTLGKPGSY-----------------------------------------LAGIDR AGNV--------------------------KPMTIGAR---------------------------------LYRVEQ-QL SVMDKKLDQ--LVYVLNAVAQKQQ---------IPLRSIEDDV------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Homo_sapiens_KCNQ3 -------------------------------------------------------------------------------- -----------------------MGLKARRAAGAA-GGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLA LGAGADKDGTLLLEGGGRDE----------GQRRTPQGIGLLAKTPLS-RPVKRNNAKYRRIQTLIYDALERPRGWALLY -HALV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK ELITAWYIGFL----TLILSSFLVYLVEKDVPEVDAQGE------EMKEEFETYADALWWGL------------------ -------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT WRFYESVVSFPFFRKEQ-------------------------LEAASSQKLGL--------------------------- -------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV---------------------- -------DAIE-------------------------------------------------------------ESPSKEPK PV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPMAE-----------------DRGYGNDF PIEDMIPTLKAAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR-------------- ----------------------IDMIFTPGPPSTPKHKKSQKGS----------------------------AFTFPSQQ SPRN------------EPYVAR-PSTSEIEDQSMMG----------------------------------KFVKVER-QV QDMGKKLDF--LVDMHMQHMERLQVQVTEYYPTK---GTSSPAEAEKK-EDNRYSDL-----KT---------------- -------IICNYSETGPPEPPYS-FHQVTIDKVSPYGFFAHDPVN-------LPRGGPSSGKVQATPPSSATTYVERPTV LPILTLLDSRVSCHSQ---------ADLQGPYSDRISPRQRR-------------------------------------- ---------------------SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDY---------------VFGPNGGS SWMREK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-ISDSVWTPSNKPI----------------------------- -------- >Macaca_mulatta_KCNQ3 -------------------------------------------------------------------------------- -----------------------------------------------------XGDAAAAGDEERKVGLAPGDVEQVTLA LGAGADKDGTLLLEGGGRDE----------GQRRTPQGIGLLAKTPLT-RPVKRNNAKYRRIQTLIYDALERPRGWALLY -HALV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK ELITAWYIGFL----TLILSSFLVYLVEKDVPEVDAQGE------EMKEEFETYADALWWGL------------------ -------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT WRFYESVVSFPFFR--Q-------------------------LEAASSQKLGL--------------------------- -------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV---------------------- -------DAIE-------------------------------------------------------------ESPSKEPK PV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPTAE-----------------DRGYGNDF PIEDMIPTLKAAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR-------------- ----------------------IDMIFTPGPPSTPKHKKSQKGS----------------------------AFTFPSQQ SPRN------------EPYVAR-PSTSEIEDQSMMG----------------------------------KFVKVER-QV QDMGKKLDF--LVDMHMQHMERLQVQVTEYYPTK---GTSSPAEAEKK-EDNRYSDL-----KT---------------- -------IICNYSETGPPEPPYS-FHQVPIDKVSPYGFFAHDPVN-------LPRGGPSTGKVQAAPPSSATTYAERPTV LPILTLLDSRVSCHSQ---------ADLQGPYSDRISPQQRR-------------------------------------- ---------------------SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDY---------------VFGPNGGS SWMREK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-ISDSVWTPSNKPI----------------------------- -------- >Mus_musculus_KCNQ3 -------------------------------------------------------------------------------- -----------------------MGLKARRAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKVGLAPGDVEQVTLA LGAGADKDGTLLLEGGGREE----------GQRRTPQGIGLLAKTPLS-RPVKRNNAKYRRIQTLIYDALERPRGWALLY -HALV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK ELITAWYIGFL----TLILSSFLVYLVEKDVPEMDAQGE------EMKEEFETYADALWWGL------------------ -------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRLDLVAT WRFYESVVSFPFFRKEQ-------------------------LEAAASQKLGL--------------------------- -------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV---------------------- -------DAIE-------------------------------------------------------------ESPSKEPK PV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPMAE-----------------DRGYGNDF LIEDMIPTLKAAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR-------------- ----------------------IDMIFTPGPPSTPKHKKSQKGS----------------------------AFTYPSQQ SPRN------------EPYVAR-AATSETEDQSMMG----------------------------------KFVKVER-QV HDMGKKLDF--LVDMHMQHMERLQVHVTEYYPTK---GASSPAEGEKK-EDNRYSDL-----KT---------------- -------IICNYSETGPPDPPYS-FHQVPIDRVGPYGFFAHDPVK-------LTRGGPSSTKAQANLPSSGSTYAERPTV LPILTLLDSCVSYHSQ---------TELQGPYSDHISPRQRR-------------------------------------- ---------------------SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDY---------------VFGPSGGS SWMREK-RYLAEGETDTDTDPFTPSG-SMPMSSTGDG-ISDSIWTPSNKPT----------------------------- -------- >Bos_taurus_KCNQ3 -------------------------------------------------------------------------------- -----------------------MGLKARRPAGAAGGGG-DGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLA LGAGADKDGTLLLEGGGRDE----------GQRRTPQGIGLLAKTPLS-RPVKRNNAKYRRIQTLIYDALERPRGWALLY -HALV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAVLTTFR---EYETVSGDW----------------------------------------------L LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK ELITAWYIGFL----TLILSSFLVYLVEKDVPEVDAQGE------EMKEEFETYADALWWGL------------------ -------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT WRFYESVVSFPFFRKEQ-------------------------LDPAASQKLGL--------------------------- -------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV---------------------- -------DAIE-------------------------------------------------------------ESPSKEPK PV-G-SNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPTAE-----------------DRGYGNDF LIEDMIPTLKAAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR-------------- ----------------------IDMIFTPGPPSTPKHKKSQRGA----------------------------AFTYPSQQ SPRN------------EPYVAR-PSTSETEDQSMMG----------------------------------KFVKVER-QV HDMGKKLDF--LVDMHLQHMERLQVHVAGFSPSK---GASSPAEAEQK-EDRRDADL-----KT---------------- -------IICNYSETGAPDAPYS-FHQVPVDKVGPYGFFAHDPVN-------LPLGGPSSGKGHA------TPYAERPTV LPILTLLDSRGSYRSQ---------VELHGPCSDRVSPRQRR-------------------------------------- ---------------------SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDY---------------AFGPSGGS SWMREK-RYLAEGETDTDTEPFTPSG-SLPLSSTGDG-ISDSIWTPSGKPT----------------------------- -------- >Myotis_lucifugus_KCNQ3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------QTPSS -FPPR--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L LLLETFAIFVFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK ELITAWYIGFL----TLILSSFLVYLVEKDVPEVDAQGE------EMKEEFETYADALWWGL------------------ -------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT WRFYESVVSFPFFRKEQ-------------------------LEAAASQKLGL--------------------------- -------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV---------------------- -------DAIE-------------------------------------------------------------ESPSKEPK PV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPMAE-----------------DRDYGNDF -IEDMIPTLKAVIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR-------------- ----------------------IDMIFTPGPPSTPKHKKSQKGA----------------------------AFTYPSQQ SPRN------------EPYLAR-ASTSEMEDQSMMG----------------------------------KFVKVER-QV QDMGRKLDF--LVDMHMQHMERLQAHVPYYDPAK----GTSPAAEEER-GDPRDSEM-----KT---------------- -------ILCNYSETGLPDPSFS-FHQVPIDKVSPYRFFAHDPVG-------LPRGGPGSGRVPGTLSSSTPAYMERPTV LPILTLLPSP----------------------TDPHGLRQRR-------------------------------------- ---------------------SFTRDSDTPLSLMSVDHEELERSPSGFSISQDRDD----------------VFGLGGGS SWMREK-RYLAEGETDTDTDPFTPSS-SMPLSSTGDG-ISDSIWTPSNKPV----------------------------- -------- >Monodelphis_domestica_KCNQ3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK ELITAWYIGFL----TLILSSFLVYLVEKDVPEIDAQGV------EMKEEFETYADALWWGL------------------ -------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT WRFYESIVSFPYFRQQL--------------------------EAAASQKLGL--------------------------- -------------------------------LDRVRLSNP---RGTNTKGKLFTPLNV---------------------- -------DAIE-------------------------------------------------------------ESPSKEPK NV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGEPMAE-----------------ERGYSNEF LIEDMIPTLKSAIRAVRPAVFALF-----CT-------------VTGLASTKYSEILFSYFFRSFR-------------- ----------------------VDMIFTPGPPSTPKHKKSQRGG----------------------------AFTYPSQQ SPRN------------DPYVAK-ASSSEIEDQSMMG----------------------------------KFVKVER-QV HDMGKKLDF--LVDMHMQHMEQLQVQVTEYYPTKK--ATATPAEAEKK-EENKYSEL-----KT---------------- -------IIYNYSEPCTQESPYS-FHQVPVNKVSPYAFFAHDPEK-------LPRTVPSS-----------VPYAERPTV LPILTLLDSRVSYHSQ---------AELHSPYQDRISPRQRR-------------------------------------- ---------------------SFTRDSDTPLSLLSVNHEELERSPSGFSISQDRDDY---------------LFGPNGGS SWMREK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-ISDSIWTPSNKPV----------------------------- -------- >Gallus_gallus_KCNQ3 -------------------------------------------------------------------------------- ------------------------------------------MGLKARRGAAGGSGAGGAAEGRRAAGGGGGDPEQGSLA LGSGADRDGTLLLEGGGKEE----------GGKRSPPGLGLLAKTPLS-RPVKRNHAKYRRIQTLIYDALERPRGWALLY -HGFV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK ELITAWYIGFL----TLILSSFLVYLVEKDVPEKDANGV------EMKEEFETYADALWWGL------------------ -------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT WRFYESIVSFPFFR-KEQ------------------------LDGTASQKLGL--------------------------- -------------------------------LDRVR--------GTNTKGKLFTPLNV---------------------- -------DAIE-------------------------------------------------------------ESPSKEPK NV-V-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGEPGGE-----------------ERGDSSDF LMEDMIPTFKTAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQAR-------------- ----------------------VDMIFTPGPPSTPKHKKSQKGG----------------------------AFSYPSQQ SPRN------------DPYVAK-ASTVDTEDQSMMG----------------------------------KFVKVER-QV NDMGKKLDF--LVDMHMHHMEQLQIQVAEISPLK---ETASPAKEKR--EENKYSEL-----KT---------------- -------IIYKYTDQCTHETPYN-FQQVPVNKVSPYGFSAHGHMTHSQP---LSTGGQNSGKLQATPSS--ASYAERPTV LPIFTLMDSQVSYHSQ---------GDMQSPYSDKVSPRQRR-------------------------------------- ---------------------SLTRDSDTPLSLLSVNHEELERSPSGFSISQDRDDF---------------PFGPNGGC AWMREK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-ISDSIWTPSNKPV----------------------------- -------- >Anolis_carolinensis_KCNQ3 -------------------------------------------------------------------------------- -----------------------MGLKARKAAAAGAKAAPSSSLAAPPPRPRGPGAEPGEGPKGADLEQGGGG------- -GAGADKDGTLLLGRPTREEEDDDEEEGLPQRRSAGQGLGLLAKTPLSRHPVKRHNLKYRRSQTLIYDALERPRGWALLY -HAFV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAVLTTFK---DYEKASEKW----------------------------------------------L LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK ELITAWYIGFL----TLILSSFLVYLVEKDVAETNEQGQ------ETR-DFETYADALWWGL------------------ -------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLVGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRLDLVAT WRFYESVVSFPYFRKEQ--------------------------VDGTSQKLGL--------------------------- -------------------------------LDRVR--------GTNTKGKLFTPLNV---------------------- -------DAIE-------------------------------------------------------------ESPSKEPK SVVV-LNNRERFRTAFRMKAYAFWQSSED-----------------AGTGDPLAE-----------------DRGYSNEL ITEDMIPTLKAVIRAVRILQFRLY-----KKRFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR-------------- ----------------------IDMIFAPGPPSTPKHKKSQKGG----------------------------TFSYPSQQ SPRN------------EPYIAK-ASTVDSEDQSMMG----------------------------------KFVRVER-QV HDMGKKLDF--LVDMHMQHMEQLQVQVTEVCPSK---EASSPA------EDNRYSEL-----KS---------------- -------IIYKYSEPSIHEKPPS-FHHVPVNKVPPFGFTTQGQSCGPFP---SPFGGQNSSRWPAMPFS--TSYAERPTV LPILTFIDPHISYQSPP--------GDFQSPHSERIPSRQKH-------------------------------------- ---------------------SVTRDSDTPLSLLSVNHEELERSPSGFSISQDRDDF---------------LFGPNGGS SWMKEK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-LSDSIWTPSSKPV----------------------------- -------- >Xenopus_tropicalis_KCNQ3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------WAANW -ATLM--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAILTTFK---EYEDASGDW----------------------------------------------L LLLETFALVIFGVEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIYIYIPAFS LL------TIGHNNQICCR-LVNSLQWVASHL-------------------------KGTMSYS--TWENLNLHYMAANR ELITAWYIGFL----TLILSSFLVYLVEKDVPERNEKGE------LVEEEFETYADALWWGL------------------ -------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-SAWRFYATNLSRIDLIAT WRYYETTVQFPYFRLRKE-----------------------QMDGTNRLVIHFG-------------------------- -------------------------------LFVERIGSE---KGLYGKYILFLPLGV---------------------- -------TVAA-------------------------------------------------------------PMNSKGDR GP-G-LHHCNKFHNDFQAKIQSLWSKNDA-----------------GAAGEPIAE-----------------S-GYGAEA MLEDLIPTIKAAIHASRILQFLLH-----KKRFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR-------------- ----------------------IDMVFAPGPLSTPKHKKSQKGTGGLGG-----------------------GFGYSSQQ SPRH------------DPYSVK---VPEIEDQSMMG----------------------------------KFVKVER-QV QDMEKKLDF--LVDMHMQHMDQLQVHITEYYPLR-----ETLAEDEGV--DSRYSEV-----EG---------------- -------LIYNYTESCAHTSPYHHLHQVSFNKTNQYGFFENYPRNFSAP---LPFNGENCPRVATPPSS---SYTERPTV LPIQTLIDTRVEFQDS---------GGASNPYLKEASPTQRR-------------------------------------- ----------------------SFRDSDTPLSLLSVNHDELQRSPSGFSISQEKEDF---------------SFGNN-GS NWMREK-RFLAEGETDTDTDPFTPSG-PITLSSTGDG-ISESAWTPS-KPV----------------------------- -------- >Tetraodon_nigroviridis_KCNQ3_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------------GFSLVF -HVFR--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAVLTTFK---EHEKVSAHW----------------------------------------------L VILETFAIFIFGAEFALR-----------------IWAAGCRCRY-KGWRGRLQFARKAA------LRAGDIFVLIASVP VV------AVRNQGNVLAT--LRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAIYAHSK ELITAWYIGFL----SLILASFLVYLVEKDDVSVDASDPESPTAQPRTQDFDTYADALWWG------------------- ------------------------------------AGRSDG-PHSCEQRTVG---ALVG-------------------- ----------------------------------------------DRRNL---PHAD--G-SSWN--QTN--------- -NLSGLIRNLLCCPS--------------------------------SQKLRL--------------------------- -------------------------------LERVRLPNA---P----------TGSS---------------------- -------DGAE-------------------------------------------------------------ESPSK--- PA-G-FSNRERLRTAFRMRAYTLRQSSEDP----------------AAPTEAAVE-----------------ERGFPPDI LLEEMIPTLKLVIRAVRILQFLLN-----KKRFKETLRPYDVKDVIEQYSAGHLDMLCRIKYLQTR-------------- ----------------------IDMILAPGPPLTPKQKKSQKPP-----------------------------FACPSSQ SPRH------------ESFLPKAASLPDAEDQSMMG----------------------------------RFVRVER-QV EDMEKKLDF--LVDMHIQHTEHLQVDSVGTAHMTL--EACHPTGN---------GEI-----RR---------------- -------VFLNYAEGFP---HMA--YQVPVGGASR------TREGQ----------RLP---------AAVPTYTERPTV LPISSLQDQAGGVART---------------------------------------------------------------- ---------------------TGGRGADTPLSMLSVNHEELERSPSGFSISGERDGED----G---------GGPSAGAT VRTRARPTHLAEGETDTDTDPFTPSGGPLPLSSTGEG-FGESVWATPP-------------------------------- -------- >Gasterosteus_aculeatus_KCNQ3_a -------------------------------------------------------------------------------- ------------------------------------------------------------ASGSEEQKQTCGAPPGDLDQ GTGGADRDGALLLAAPGREDFKRGSQGIGIGLLAKTPLN--------YTGPAKRNNNRRRRIQNLLYDALERPRGWALLY -HAFV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAILTTFR---EHEKVSAHW----------------------------------------------L VILETFAIFIFGAEFGLR-----------------VWAAGCCCRY-KGWRG----------------------------- EA------QVR--------------KLLCILG-------------------------KHVSNVG------IGSSLKEHSR --VNAACRG-----------------------GTQVTEVTEVTVSHLQITLTT--------------------------- ------------------------------------IGYGDKTPKTWAGRLLAGTFALIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRH---PAAGLIQ-SAWRYYSTNPIREDLIAT WRFYETIISLPCFRKDH-------------------------LEAIASQKLSL--------------------------- -------------------------------LERVRLPNA---RPSIGTGKRL-TGHT---------------------- -------DSIE-------------------------------------------------------------ESPSKEPK PA-G-FSNRERFRTAFRMKAYTLRQSSEDG----------------GALAEPALE-----------------ERGFPPDI LMEEMIPTLKLVIRAVRIMQFLLN-----KKRFKETLRPYDVKDVIEQYSAGHLDMLCRIKYLQTR-------------- ----------------------IDMILAPGPLLTPKQKKTPKAP-----------------------------FNYPANQ SPRH------------ESYLAKATSIPDVEDLSMMG----------------------------------RFVRVER-QV EDMEKKLDF--LVDMHIQHSEHLQVDSAGAAHMTL--EACNPTGA---------GEI-----RR---------------- -------VFFNYAESFP---HLS--YQMPVGKMSGGSGG--GGGHQ----------PPPPLLHQRRPPAAVPTYAERPTV LPISSLQDLSAGPGRT---------------------------------------------------------------- ---------------------TGARGGDSPLSMLSV-HDELERS-SGFSISGSR-----------------------MKP AGRDPDPSYLAEGETDTDTDPFTPSGGALPLSSPGEG-FGDAVWNTPP-------------------------------- -------- >Oryzias_latipes_KCNQ3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLIVLGCLILAILTTFK---EHENTSAHW----------------------------------------------L VILETFAIFIFGAEFGLR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCILDIFVLIASVP VV------VVRNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAIYAHSK ELITAWYIGFL----SLILASFLVYLVEKDDVSVDGSDREDPTVQPKQQDFDTYADALWWGL------------------ -------------------------------ITLTTIGYGDKTPKTWAGRLLAGTFALIGVSFFA----LPA--GILGS- -------------------------------GLALKVQEQHRQKHFEKRRH---PAAGLIQ-SAWRYYSTNPVRDDLIAT WRFYETIISLPCFRQDT-------------------------FEVMVSQKLSL--------------------------- -------------------------------LERVRLSNT---RPSVGMGKRL-MGNA---------------------- -------DSVE-------------------------------------------------------------DSPSKESK PA-G-FSNRERFRTAFRMKAYTLRQSSEDA----------------GALADPALE-----------------ERGFPPDI LMEDMIPTLKLVIRATRIMQFLLN-----KKRFKETLRPYDVKDVIEQYSAGHLDMLCRIKYLQTR-------------- ----------------------IDMILAPGPLLTPKSKKTQKTP-----------------------------FSYPANQ SPRQ------------ESYLPKTTAMPDTDDQSMMG----------------------------------RFVRVER-QV EDMEKKLDF--LVDMHIQHTEHLQVDSAGTAHMTL--ETCGPGAN---------GEI-----RR---------------- -------VFLNYSEAFP---HMS--YQVAIGKAGRGRGDQECRRGA----------GLARGHPERPAMGTVPTYIERPTV LPISSLQDLSAGPGRT---------------------------------------------------------------- ---------------------TGRQGGDSPLSMLSVNHEELERSPSGFSISVDREGDERVPTE---------ADMATGEV SWTRPRPSYLAEGETDTDTDPFTPSGGALPLSSTGEG-FCDAEWNAPL-------------------------------- -------- >Drosophila_melanogaster_KCNQ3 -------------------------------------------------------------------------------- ----------------------------------------------MDPDNDIYAFY----------------------- ----------------DIRGYKGKCRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHAIF YHVMV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLMVFTCLALSVFSTIKEYEEDA-------------------------------------------------VYIL FRMEILVVIWFTMEFGAR-----------------LWSSGCRSRY-QGCLGRLKFVKRPF-------CIIDIVTILASIV VL------GMGTSGQVFATSALRGLRFFQILR-------------------------MVRMDRRGGTWKLLGSVVYAHRQ ELITTMYIGFL----GLIFASFLVYMWEKDVN----------------DKFSNFAQALWWGV------------------ -------------------------------ITLCTVGYGDMVPITWQGKLIASCCALLGISFFA----LPAG--ILGS- -------------------------------GFALKVQQQQRQKHMIRRRQ---PAATLIQA-VWRCYAADE-HSVSVAT WNIHRVALPSPPAS-----------------------RASSSFKHNTSFVARLP-------------------------- -----------------------------TIRRHKSQ------TIQTPGGGDGGGVSKPPG------------------- --------------------------------------------------------------------------SSRAST RYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDDEEDEPR-------------------------- -CTQLTNRHKTAIRFIRKLKYFVA-----RRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLR-------------- ----------------------LDQILGKQ--------------------------------------------GSKAKD VYAS--------------------------KISLAS----------------------------------RVVKVER-QV ADIEEKLDI--LIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTT-------- -------PLLNPSAPDSSELRSLTATQTPTTTTDAIATQTPMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELEN RTKKRVTLS-LHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTP------------------------------------ -------------------------PDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDIG-VEVDVDADADGDCDES TEDTALLQCATRTAIVITPISPVSSAHNLQQLNDQTTTLNKSNLLPPDSG------------------------------ -------- >Homo_sapiens_KCNQ2 -------------------------------------------------------------------------------- --------------------------------------------------------------MVQKSRNGGVYPGPSG-E KKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG--GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY -HAYV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVFSTIK---EYEKSSEGA----------------------------------------------L YILEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK ELVTAWYIGFL----CLILASFLVYLAEK----------------GENDHFDTYADALWWGL------------------ -------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS- -------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQS-AWRFYATNLSRTDLHST WQYYERTVTVPMYSSQT-----QTYGASRLIPPLNQLELLRNLKSKSGLAFRKD---PPPEPSPS--------------- ---------------------------QKVSLKDRVFSSP---RGVAAKGKGSPQAQ---------------------TV RRSPSADQSLE-------------------------------------------------------------DSPSKVPK SWS--FGDRSRARQAFRIKGAASRQNSE----------------EASLPGEDIVD----------------D-KSCPCEF VTEDLTPGLKVSIRAVCVMRFLVS-----KRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQS--------------- ---------------------RVDQIVGRGPAITDKDR------------------------------------TKGPAE AELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV LSMEKKLDF--LVNIYMQRMGIPPTETEAYFGAK----EPEPAPPYHSPEDSREHVD-----RHGCIV------------ ------KIVRSSSSTGQKNFSAPPA--APPVQCPPSTSWQP---------QSHPRQGHGTSPV---GDH-GSLVRIPPPP AHERSLSAYGGGNRA--------SMEFLRQEDTPGCRPPEGNL------------------------------------- ------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNS-------------CYAAV APCAKVRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFGDVGWAGPRK------------------------------- -------- >Pan_troglodytes_KCNQ2 -------------------------------------------------------------------------------- --------------------------------------------------------------MVQKSRNGGVYPGPSG-E KKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG--GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY -HAYV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFS---------------------------------------------------------------------- -WLEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK ELVTAWYIGFL----CLILASFLVYLAEK----------------GENDHFDTYADALWWGL------------------ -------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS- -------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQS-AWRFYATNLSRTDLHST WQYYERTVTVPMYSSQT-----QTYGASRLIPPLNQLELLRNLKSKSGLAFRKD---PPPEPSPSKGSPCRGPLCGCCPG RS------------------------SQKVSLKDRVFSSP---RGVAAKGKGSPQAQ---------------------TV RRSPSADQSLE-------------------------------------------------------------DSPSKVPK SWS--FGDRSRARQAFRIKGAASRQNSE----------------EASLPGEDIVD----------------D-KSCPCEF VTEDLTPGLKVSIRAV---------------------------------------------------------------- ----------------------VDQIVGRGPAITDKDR------------------------------------TKGPAE AELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV LSMEKKLDF--LVNIYMQRMGIPPTETEAYFGAK----EPEPAPPYHSPEDSREHVD-----RHGCIV------------ ------KIVRSSSSTGQKNFSAPPA--APPVQCPPSTSWQP---------QSHPRQGHGTSPV---GDH-GSLVRIPPPP AHERSLSAYGGGNRA--------SMEFLRQEDTPGCRPPEGTL------------------------------------- ------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNS-------------CYAAV APCAKVRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFGDVGWAGPRK------------------------------- -------- >Mus_musculus_KCNQ2 -------------------------------------------------------------------------------- --------------------------------------------------------------MVQKSRNGGVYPGTSG-E KKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTG--GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY -HAYV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVFSTIK---EYEKSSEGA----------------------------------------------L YILEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK ELVTAWYIGFL----CLILASFLVYLAEK----------------GENDHFDTYADALWWGL------------------ -------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS- -------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQS-AWRFYATNLSRTDLHST WQYYERTVTVPMYSSQT-----QTYGASRLIPPLNQLELLRNLKSKSGLTFRKE---PQPEPSPS--------------- ---------------------------QKVSLKDRVFSSP---RGMAAKGKGSPQAQ---------------------TV RRSPSADQSLD-------------------------------------------------------------DSPSKVPK SWS--FGDRSRTRQAFRIKGAASRQNSE----------------EASLPGEDIVE----------------DNKSCNCEF VTEDLTPGLKVSIRAVCVMRFLVS-----KRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQS--------------- ---------------------RVDQIVGRGPTITDKDR------------------------------------TKGPAE TELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV LSMEKKLDF--LVSIYTQRMGIPPAETEAYFGAK----EPEPAPPYHSPEDSRDHAD-----KHGCII------------ ------KIVRSTSSTGQRNYAAPPA--IPPAQCPPSTSWQ----------QSHQR--HGTSPV---GDH-GSLVRIPPPP AHERSLSAYGGGNRA--------STEFLRLEGTPACRPSEAAL------------------------------------- ------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDALGS-------------CYAAV APCAKVRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFGDVAWAGPRK------------------------------- -------- >Rattus_norvegicus_KCNQ2 -------------------------------------------------------------------------------- --------------------------------------------------------------MVQKSRNGGVYPGTSG-E KKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTG--GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY -HAYV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVFSTIK---EYEKSSEGA----------------------------------------------L YILEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK ELVTAWYIGFL----CLILASFLVYLAEK----------------GENDHFDTYADALWWGL------------------ -------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS- -------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQS-AWRFYATNLSRTDLHST WQYYERTVTVPMYSSQT-----QTYGASRLIPPLNQLELLRNLKSKSGLTFRKE---PQPEPSPS--------------- ---------------------------QKVSLKDRVFSSP---RGVAAKGKGSPQAQ---------------------TV RRSPSADQSLD-------------------------------------------------------------DSPSKVPK SWS--FGDRSRARQAFRIKGAASRQNSE----------------EASLPGEDIVE----------------DNKSCNCEF VTEDLTPGLKVSIRAVCVMRFLVS-----KRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQS--------------- ---------------------RVDQIVGRGPTITDKDR------------------------------------TKGPAE TELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV LSMEKKLDF--LVSIYTQRMGIPPAETEAYFGAK----EPEPAPPYHSPEDSRDHAD-----KHGCII------------ ------KIVRSTSSTGQRNYAAPPV--MPPAQCPPSTSWQ----------QSHQR--HGTSPV---GDH-GSLVRIPPPP AHERSLSAYSGGNRA--------STEFLRLEGTPACRPSEAAL------------------------------------- ------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDALAS-------------CYAAV APCAKVRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFGDVAWAGPRK------------------------------- -------- >Gallus_gallus_KCNQ2 -------------------------------------------------------------------------------- --------------------------------------------------------------MVQKSRNGGVYPGPAA-E KKLKVGFVGLDPGAPDSSRDGALLIAGSESTKRGSILSKPRSG--VSGSGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY -HAYV--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----FLLVFSCLVLSVFSTID---EYQNSSEGA----------------------------------------------L YILEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK ELITAWYIGFL----CLILASFLVYLAEK----------------GENEHFDTYADALWWGL------------------ -------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS- -------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQA-AWRFYATNLSRTDLHST WQYYERTVTVPMYSTQT-----QTYGASRLIPPLNQLELLRNLKSKSGLTFRKE---QQPEPSPS--------------- ---------------------------QKVSLKDRVFSSP---RGAGTKGKGSPQAQ---------------------GI RRSPSADQSIE-------------------------------------------------------------DSPSKVPK SWS--FGDRSRARQAFRIKGAASRQNSE----------------EASLPGEDIPD----------------ENKSCNCEF VTEDLTPGLKVSIRAVCIMRFLVS-----KRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKNLQSR-------------- ----------------------VDQIVGRGSSMTNKDR------------------------------------TKGPAE GELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV QSMEKKLDF--LVNIYMQRMGIPPTETEAYFGSK----EPDPAPPYHSPEDSREHID-----KNGCII------------ ------KIIRSTSSMGQKNFSAPPA---PTNSCPPSTSCQQ---------QPYQRQSHGSSPV---GDP-GSLVRIPPPP SHERSLSAYSGGHRA--------SAEYLRNEDIT-TKHHESAL------------------------------------- ------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDILNNG------------CYAAV A---KIRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFSDMGWSAPRQ------------------------------- -------- >Anolis_carolinensis_KCNQ2 -------------------