>Homo_sapiens_MROH5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MDRQCSERPY-----------SCTPTGRVSSAVSQNSRISPPVSTSMKDS S-CMKVHQDSARRDRWSHPTTILLHKSQSSQATLMLQEHRMFMGEAYSAATGFKMLQDMNSADPFHLKYIIKKIKNMAHG SPKLVMETIHDYFIDNPEISSRHKFRLFQTLEMVIGASDVLEETWEKTFTRLALENMTKATELEDIYQDAASNMLVAICR HSWRVVAQHLETELLTGVFPHRSLLYVMGVLSSSEELFS-QEDKACWEEQLIQMAIKSVPFLSTDVWS-KELLWTLTTPS WTQQEQSPEKAFLFTYYGLILQAEKNGATVRRHLQALLETSHQWP---------------------------KQREGMAL TLGLAATRHLDDVWAVLDQFGRSRPIRWSLPSSSPK------------------------------------NSEDLRWK WASSTILLAYGQVAAKARAHILPWV------------------------------------DNIVSRMVFYFHYSSWDET LKQSFLTATLMLMGA------------VSRSEGAHSYEFFQTSELLQCLMVLMEKEPQDTLCTRSRQQAMHIA------- ------------------SSLCKLRPPIDLERKSQLLSTCFRSVFALPLLDALEKHTCLFLEPPNIQLWPVAR------- -------------------------------------------------------------------------------- --------------------------------ERAGWTHQGWGPRAVLHCSEHLQSLYSRTMEALDFMLQSLIMQNPTAD ELHFLLSHLYIWLASEKAHERQRAVHSCMILLKFL------------------------------NHNGYLDPKEDFKRI GQLVGILGMLCQDPDRATQRCSLEGASHLYQLLMCHKTGEALQAESQAPKELSQAHSD------GAPLWNSRDQKATPLG PQEM--AKNHIFQLCSFQVIKDIMQQLTLAELSDLIWT----------AIDGLGSTSPFRVQAASEMLLTAVQEHG-AKL EIVSSMAQAIRLRL----CSVHIPQAKEKTLHAIT-LLARSHTCELVAT---FLNISIPLDSHTFQLWRALGAGQPTSHL VLTTLLACLQERPLPTGASDS-----SPCPKEKTYLRLLAAMN----MLHELQFAREFKQAVQEGYPKLFLALLTQMHY- -----------VLELNLPSEPPKQQAQEAAV----PSPQ----------SCSTSLEALK---------SLLSTTGHWHDF AHLELQGSWELFTTIHTYPKGVGLLARAMV--QNHCRQIPAVLRQLLPSL---QSPQERERKVAILILTKFLYSP----- -VLLEVLPKQAALTVLAQGLHDPSPEVRVLSLQGLSNILFHPDKGSLLQGQLR------------------PLLDGFFQS SDQVIVCIMGTVSDTLHRLGAQGTGSQ--SLGVAISTRSFFNDERDGIRAAAMALFGDLVAA-------------MADRE LSGLRTQVHQSMVPLLLHLKDQCP-AVATQAKFTFYRCAVLLRWRLLHTLFCTLAWERGLSARHFLWTCLM------TRS QEEFSIHLSQALSYLHSHSCHIKTWVTLFIGHTICYHPQAVFQMLN----AVDTNLLFR--------------------- -------------------------------------------------------------------------------- -----------------------TFEHLRSDPEPSIREFATSQLSFLQKVSARPKQ------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Macaca_mulatta_MROH5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MDGQCSERPH-----------SHTPTGRMSSAVSQNSRISLPVSTSTKDS S-CMKAPQDSACRDRWSHPTTILLHKSQSSQAALMPQEHGMFMAEAYSAAICLKMLQDMNGADLFHLKYIIKKIKNMARG SPKLVMETIHNYFIDNPEISSRHKFRLFQTLEMVIRASDVLEETWEKTFMQLALENMTKATELEDTYQDAASNVLVAICR HSWQAVAQHLETELLTGIFPHRSLLYVMGVLSSSEELFS-QEDKACWEEQLIQMAIKSVPFLSMDVWS-KELLWTLTTPS RTQQEQSPEKAFLFTYYGLILQAEKNSATVRRHLQALLETSHQWP---------------------------KQREGMAL TLGLAATRHLDDVWAVLDQFGRSRPIRWSLHSSSPK------------------------------------NSEDLRWK WASSTILLAYGQMAAKARAHILPWV------------------------------------DNIVSRMVFYFHYSSWDET LKQSFLTATLMLMGA------------VSRNEGAHSYEFSQTSELLECLMVLMEKEPQDTLYTRSRQQTMHIA------- ------------------SSLCKLRPPIDLERKSQLLSTCFRSVFALPLLDALEKHTCLFLEPPNIQVWPMAR------- -------------------------------------------------------------------------------- --------------------------------EWAGWMHQGWGPGAVLHCSELLQNLYSRTMEALDLMLQSLIMQNPTTD ELHFLLSHLYIWLASEKAHERQRAVHSCMILLKFL------------------------------NHKGNLDPKENFKRI GQLVGILGMLCQDPDRAIQRCSLEGASHLYQLLMCHK-GEFCGAPTSTPTATSGRPTP-------SPLTSTLPQFAPKPN PD----LNHNPGRGEAWPPGPGISMEYECGKEPG-PWF----------ALTDVDVCNPFRVQAASEMLLIAVQEHG-DKL KIVSGMAQAICLHL----CSVRIPQAKEKTLHAIT-LLARSHTRELVTT---FLDISIPLDSHTFQLWRALGAEQPTSHL VLTMLLAWLQERPLPTSASDS-----SPCPKEKTYLRSLAAMN----MLHELQFARECCQACQRGLP--LPCSSTNKAF- -----------SLETFPAKPGPSHQPQEASA----SPEP-------PLLSCSTSLEALK---------SLLSTTGHWRDF AHLELQGSWELFTTIHTYPKGVGLLARTVGPGQNHCRQIRAVLRQLLPSL---QSPEERERKVAILILTEFLYSP----- -ALLEVLPKQAALTVLTQGLRDPSPEVRVLSLQGLSNILFHPDKGSLLRGQLR------------------PFLDGFFQS SEQVIVCIMDTVSDMLHRLGAQGAGSQ--SLSVAISARSFFNDERDRIRAAAMALFGDLVAA-------------MADRE LSGLRTQVHQSMVPLLLHLKDQCP-AVTTQAKFTFYRCAVLLRWRLRHTLFCTLAWERGLSARHFLWTCLV------RGL G---SVGRNRAKEWGPGLRLPIHSR------HTICCHPQAVFQMLN----AGDINLLLC--------------------- -------------------------------------------------------------------------------- -----------------------TFEHLKSDPEPSIREFATSQQSFLQKVSARPKQ------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Canis_familiaris_MROH5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MSQNPRAAQRQA-----------GTRGNPEGDAPCPASHRISSPISRSMKDL S-CMKVPQDPAHRDKQAHPTTILLCKSRSSQAALMPKEHKMFMEEAYNAAICFKMLRDLNGSDPLHLKYIIKKIKGMAYR APNLVLETIHDYLVDNPEISSRHKFRLFHVLEAVIEASNSLEEAWQKSFMQLALENMTKSTELEEVYQDAASDVLLAICR HSWRMVAQHLETEVLTGVFPHRSLLYVMGILTSNEAIFN-EGEKACWEEQLAQLAVKSVQFLNTDMWS-KELLLALTKPD RTHQEQPPEKAFLFIYYGLILQAEDNSTTVRTHLRTLLDTSHQWP---------------------------KQREGIAL TIGLAAARHLDHVWAVLEQFGRSTPIKWSLHSFCLK------------------------------------NAEDLQWK WASSTILLSYGQMAVRAKAHILPWV------------------------------------DNILSRMVFYFHYSSWDET LKQSFLSAVLMLVGA------------VSRNEGAHSYEFSQVSELLDCLMVLMEKEPRDTLCTPTRQQTIHII------- ------------------SSLCKLRPPLDLEKKSQLLSTCLHSVLALPLLDVLEKHTCLFLEPPNIQAGPLAP------- -------------------------------------------------------------------------------- --------------------------------YRRGADAGAWRPPDLPHV--PTQTLYNKTSSALDQLLQSFIMQSPTTD ELHLLLSHLYPWLASEKAQERQRAVDRSTALLRFL------------------------------SHSHSLDPKEDFRRI GQLVGMLGILCQDPDRAIQQSSVEGLGHLYQLLISQTARAAPMVNAQAPKQLSPASVD------GAPVWSSGDQKTAPPT PPEMTFPKDHIFQLDSSQVIKEVMKHLTKAELTDLIWT----------AIEGLGSASPFRVQAAADMLLTTIREHG-AKL ETVANLGRAIHLQL----CSVCIPQAKEKALHAIT-LLAQNHTPELVAT---FLDFSVPLDSHAFCLWRALGAEQPVSRQ VLAVLLAWLQERALPPGPRDG-----SPQPKDKPCPRSLAAMN----MLHELQFAREFKKAVQEAFPQLLLALLAQLHY- -----------TLELHLPQEP--HLPQERQG----WSVT-------PPSHCSTSLEALK---------SLLSTTGHWQDF AHLELQGGWKLFSTIDTYPQGVSLLARAMV--QNHCKQIKAVTSQLLPNL---QSKEARERKVAILILTEFLYSP----- -TLLEVLPRQAALIVLARSLRDPSPEVRVLSLQGLGNILFHPEKESLLRRQLP------------------PFLDGFFQN NEQVVVQVMGTVSDVLHRLGAHSAAAQ--SLGVAINARSFFDDERDGIRAAAMALFGDLVAA-------------MAGKE LSSLRTQVHQSMVPLFLHLKDHCPGVVT-QAKFTLYRCAVLLRWRLRHTLFCTLAWERGLSARHFLWTCLM------THS QEEFGIHLAQALSYLHSRHRHIKTWAALFIGYTICYHPQAVSQMVS----SVDTNLLFS--------------------- -------------------------------------------------------------------------------- -----------------------TFEDLKKDPEPSIRVFATRQLYFLQKVAARP-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Felis_catus_MROH5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MDEQNSEKSH-----------SHASADRTSSAVSQNPRTSSHVSKSMKEL S-YLKVPQDPSRKDRQGHPTTIILCKSQSSQVAVEPKEHSMFMEETYSAAICFKMLQDLNGSDTRGLKYIIKKIKNMAHE APNLVLETIHDYFVNNPEMSCRHRFWLFQVLEAAIEASDSLEEAWEKTFMKLALENMTKSTELEEVYQDAASNVLLAICR HSWQVVAQHLETEVLTGVFPHRSLLYVMGILTSNESIFQ-KGEKACWEKQLAQMAGKSVQFLHMEKWS-KELLSALTKPD QTHQEQPPEKAFLFVYYGLILQNEDNATTVRTHLRTLLDTSHQWP---------------------------KQREGIAL TVGLAATRHLDHVWAVLEQFGRSTPVKWSLHSFCLK------------------------------------KSEDPKWR WASSTMLLAYGQMAVKAKAHILPWV------------------------------------DNILSRMVFYFHYSSWDET LKQSFLTAIFMLVGA------------ISRNEGAHSYEFSQISELLECLMVLMEKEPQDTLCTSTRQQTIHII------- ------------------SSLCKLRPPLDLKRKSRLLSVCLRSVFALPLMDVLKKHTCLFLEPPNIQLAPSMS------- -------------------------------------------------------------------------------- --------------------------------TPGEPSSKHWGSRDLLHP--PAQTLYNKTLEALDQMLQSLIMQNPTAD ELHFLLSHMYTWLASEKTHERQRAVHSCVALLGFL------------------------------SHDLYLDTKEDFRRT GQLVGVLGILCQDPDKATRHSSLEGVGHLYQLLMRQRARELPTVEAQAPKQLSQASED------GAPIWSIGDQQTAPPT PREMAFPKDHIFQLGSSQVIKEVMKHLTVAELTDLIWT----------AVDGLGSASSFRVQAAADMLLLAIQEHG-AEL ETVAKLGRAIHLQL----CSVHIPQAKEVALHAIT-LLARNHTSELVAT---FLDPSIPLDSHTFQLWRALGAERPTSRL VVATLLAWLQERPLPPGARDG-----SPPPEDKTYLPSLTAMN----LLHELQFAREFEKAVQEAYPELLLALLTQTHY- -----------ISELNLPEEP--QPGQEAQ------PLA-------TPSPQRTSLEALK---------GLLSTTGHWQDF AHLELRGAWELFATTRTYPQGVGLLARAMV--QNRCGQIKAVTSRLLSSL---RSEEKRERKTAVLILVEFLYSP----- -MLLEVLPRQAVLTVLARSLRDPSPEVRALSLQGLGNILFHPEKGSLLQRQMP------------------AFLNGFFQN SEQVVVRVMGTVSDVLHRLGANGAAAQ--SLRVAINARSFFDDERDGIRAAAMALFGDLVAA-------------AAGRE LIGLRAQVHQSLVPLLLHLKDRCPAVVTVSARCRAFPLAGLRVCRWRQG--AALLSGSSLALGQQVWPPAL------VSV TEEFSIHLAQALSYLHSRHHHIKTWAALFIGYNICYHPQAVSQVVN----SMDTNLLLC--------------------- -------------------------------------------------------------------------------- -----------------------TFEDLKKDPEPGIREFASRQLFFLQEMAARPQ------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Loxodonta_africana_MROH5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------QAFLFYYYGLILQATEDSATVRAHLQSLLETSHQWP---------------------------KQREGMAL TMGLAAVRHLEDVWAVLDQFGRSAP-IKCSPHI----------------------------------------------- -------------------------------------------------------------------------FSPKDDT LKQSFLKGVLLLVRA------------ISRNEGAHSYEFSQAPELLDCLMILLEKESPDTLCTSIRQQAIHII------- ------------------SSLCKLRPPPDLERKSRLLSVCFRSVFALPLLEVLEKHTCLFLEPPNIQA------------ -------------------------------------------------------------------------------- --------------------------------------------------------LYDRTAEALDQLLQTFIRQTPTAE ELHFLLSHMYFWLASEKAHERQRAVHSCTALLKFL------------------------------SQNPHLDPKEEFRWT GKLVGMLGILCQDPDRATQLSSLEGMGHLYQLLMRQK-----DATASRPQIYKQLQDF------S----------NVPSR K---VPLK--------CYHLKEVMKRLTMQELTDLIWT----------AIDGLGSHSPFRVQAAAEMLLAAIQDRG-AKL DTVARLGRAIHLQL----CSVRIPQAKEHALQAIT-LLARSHTSQLVAA---FLDFSIPLDRCPAPDWIKLSAG--ARVP VEIVELVYVLKHKQFAPPRDI-----LLSTGDSRLLARSEAMN----TVHELQFTREFKVAVQEAYPELLLALLAQVHY- -----------ILELDLP-REPQPHSEIQEA----AVTS-------PQ---STSLEALK---------SLLSTTGHWHDF AHLELQGSWELFTTLPTYPQGVSLLA--RAMVQNHCQQIKAVLGQLLPSL---QSREERERKVAMLILTEFLYSP----- -ALLEVLPKQAALAVLARGLRDTSPKVRVWSLQGLGNVLFQSGKVSLLRGQLP------------------PFLDGFFQD SEPVVVRVMGTVSDVLRRLGALGAGAQ--SLGVAINARSFFDDERDGIRAAAMALFGDLVAA-------------MEGKE LGRLRAQVYQSMVPLLLHLKDHCP-AVVTQAKFTFYRCTVLLHWRLRHTLFCTLAWEQGLSARHFLWTCLM------THS QEEFHVHLTQALSYLHSCHHHIKTWAALFIG------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Ornithorhynchus_anatinus_MROH5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------ELKDAYQNAASNILVALYA HSKQLVTHKLEEEFLTGTFPHRSLLYTMGTISSSEHLQDTPEKKEYWEEQLTRVGTKSTGFLMVDDWA-QQLMWAITLSD RDCPEPTPEKAFLFTYYGMTLRASNNSALVRKHLRSLLGVSHQSP---------------------------AHREGVAL TLGLVANRHLTDAWAVLDEFGRMGPQRKCWSHLSHQV---------------------------------PDDSQDVQLK WMGSTILLSYGQIAAKAKEMILPWV------------------------------------DNIASRMVNYFHCSIWDDS LKQSFLVATLMLVRA------------ISRTEGAQSYAFHQAQELTRCLVTLVEKEPLDSLCTSARQQAMLII------- ------------------ADLSKLRPALEPKKKSHLLFTCFRSVFTLPPMEMLEKHTCLLANPPDVQVNHPAT------- -------------------------------------------------------------------------------- --------------------------------PSQPTVLSRALAPSGVFS-EHLWALFEETREALDKILQSFLSENPCPE ELHCLVGHMYSWLASERALERQRAVKSCVSLLRFT------------------------------YENLCFDSSSEFRRI GHLVGMLGLLCRDPDRVTRHLDLEGIGYLWLLLLRHKGEKELQAVTSGPEHRHNCPCH------GGPCHSEKKKKTSPSA P---VSLLGHLLHICQTTTLSTMMKVMGLIQLRDLIWT----------VLDGLRGSVHFRVEAAADMLLALLEDFG-AKL EKVADIGRTLYLQL----ASIHSVAIKTSVLKALT-LLARDHTWELVSA---FLEFSLPPDSQAFDLWRAVGTEQHVSPK VLKVLLAKLQERPLPEESKG--------AIEEKTHFKSFAAMS----TLHEVLFAHEFKAAVQEAYPELFLALVTQLHY- -----------VFELGPPGQASLPGPQRSET----NFSS-------PG--SSTALEAVK---------TLLSTSGHWKDL AHVELQGGWDLFTSLNTYQKGLTLLAS-RAMVQNRCPQLRAVLKLTVPGL---ESKHERERKVAILIFTEFLHSP----- -TILQDLPKRTILSLLHKALADPSPTVRVISLQGLGNVLFHPGKGALLQAQLG------------------GFLNGLYQD KEQVVTGVMDTMSNVLYRLAQQGAGPQ--SLDIALTLRPFFDDERDQVRAAAISLFGDLVTV-------------MEGKD RSTLKTQVCRSLVSLLLHLKDDSP-AVVTKSKFAFFRCAVFLKFRLCHTLFCTLAWEQGLSARHFIWTCLM------SNG RDEFHIHLSQALGYLHSPLQHLRMAAATFIG------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Drosophila_melanogaster_MROH5 MDGRGVGGGGSGAATGGGSANNKSAAGNSAATGNADASTATAAPNDKPTILEGVLHNIFDGLMDKEEQVRIAMQQAIVKI LETHPERAAEILSEHRSQQPKMTDQTVAMLLDCIRRVVG---AETPLPPAANQKLIDLALQELTKNPEHLPLIQNPAQRI LVAIGRSSPESCEQVMEALQEKGTSTEGVAHFMLMQCLGLLATENPAGVVPHIKAILSRSQPHLVGIRQDHIKQAHAYAI GRFSEALLE-----ESGKKEEENCST--------EISVAY-----------DVLFNQWLHSR-EPKVCVEILQALSSMYP LLPKDRIQDQAARLVPQILALYRRSV--DRNAVTQFLCSVLKTNLALNATVLDGIIDVLVTHLFDLV---CVYPDYEKPQ TVKGHYEVLRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMKSLLILTHLLNSCAGNIENRIPATIECLKQLILSERGI KMKLTLLKTIVALAQKSHIRDK---EFVWFVVRHSCRFSKP-----SQEHGSQEEHANLVLSCENTLYMLASTVGTLDEL LKRELLNYLILLDYTDICGNLAKCLASLFAKSPHIEYD-IAGDDAATEQATP----ESMGAAGEDR-SVIKRGKVMVPGA ETIYARCLALLGN-QQCIKRCSNILSFLRYYHPQVNPALEELWERKIPDLLLQINR---ESAYRQLLHDFVLETNEFLGG LDEN-FAQRLASKLADQMYLYPMQLP----------------------HSEWHLPDLSAERGMLLQAVALTLLQVTDVAC IHTKIDLIVTTARQERLDKHVKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVGG-RKHSTGFFSNLH------- ----FIKDTHKELENYKSNLLVVKAFGRIMDEADPLQSIQHLDEDDTLLGFLIQQLAVHKDQTIMSA------------- ---------------------ILQTLLSICNQLIATK-EQLPAPLRHRKQIMETVFNIPIEAPFHDLPLLPTILKLGTDF IRIGGPDTEECVDGGVIFEIACRNFFGCAQQLKMKFDSQEEDERNSFLAK-----HLNESLPQLNALVR-AIVELDASPA TLDLIIGILEGWTRDRNSEVRICASHVFNNTLDVYIKS----------------------------MKIGCEAPSKFNQT GQMLGKIVPRCIDSNGTVRQVSVEILQKTLEIACIY-ETLTIASIDSTADWLK----------------------EIETI KEHIITDEPKQIYNLAGDIAKIIALRISSFQYLQFCKT---------LLHSLRDPEQ-SSTIGASVVLKFFIQQKGSELF HAIPDLVRDSLLAL----RVCE-VPRAKSGVLKALVALTKHHPKLVCAE---MLSQPLPYDPNLVEYWHLVCNDPE-LTG LTLDNFLQLLSGASLQEGGQDASLS-------ERQKLASGQPFAIFCALHEMLPCKDIKGQLETRFADMFCMLLTSLSS- ------YTNLAAPNPINNASLSPNQTQSGKTKFGFVPNK----ELIKLNPCQIALETFQ---------AFLTNLEMEQIA SVLTVNTQLASSADWHNYIELLTPMAIGLGQQLQLGSPQMRQLVNSLSKYV--ASPYDGQRVAAVGIFSRLVPLKP---- ----TGELAASILLHLGAALSDPNAVVRGLSIQGMGYVGQLGEKEAKRYSETA--------------IGALLKGVDDPVG DCLINIPLESMRGLSGILRALPSERVEPFHVSLAIRIRPFLGNYALEMREAAIQLFGDICEGKH------DDGSSSPTSS MEALREQLIANLFPLLLHLSESEVAIA-SACRGTLQRVCRLLTAPRVVEMAEQQLGEERGHQLNYSSFVLEFVKTIALEL TDHIQDFIDSCLPQLRSQWPEVRGSAAIVIG------ILHNFLS-ERNVQTETVAS------------------------ -------------------------------------------------------------------------------- -----------------------KIAVLLKDEQALVRMRAATALGYFFGDI----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Anopheles_gambiae_MROH5 -----------------------------------------------MHISVAVVTSLLDSLNDKEELLRTTTEASLIRI AKRRHDEIVEVFCDYRKKHPKLGDTHTLIILRVISYIAT--NLIDVIDPNTASKCIQYSMAEIMKLTEQNASVQNPCREI LVAVGR---RYCKEIMEIFVKHLEQNQ-LGNFMIVQSVGALATANTLDTVPYIKPILALMLPTLSAVRQDFLRQAYAYAI GRFCEAFSEYQEYQRQNPNEETPMKTGVRYEIQDEVSIVY-----------DHFHAQWLASR-EPKLTGEVLNAFAYMYP LLPVERVSDNLAKTVPSVLALYRKSL--DRSAVTQYLASIIKTVLQLDSKLLAPMADTLVGCLFDLV---CVSPDYDKPQ TVKGHFEVLRCFDLLA--PEYGEKIIEILLIHLRNNSERERIKSLLVVTHLTNTSEPVVRDKLPEITAILRGLLATEKPV KVRIVLLRTVVAFMQKNFVRDR---EFVAFLIRCSCRPAKL-----NLDHGSAEEHQEFQRACHDTMHILSSTVGTVDRM LRAELLQAYLRYEYTDICGTIGKCLANLYAKDPELGLHGAAAAGAAPDRHSDNPFDESAGGGGVELGDEAQPGAPPPPRP IAVFVRTLALLGN-FGEQGRIQHLLAFLKSYAGSLYRHLVPLWGELLGALQAELAGGIDEQRYFALLFAFVQET---IRD VDEYTFVEGVIAEMFHQLPLYQPASGGGSGGSAGGGGGGGSGGGGAGQAAEFRVPPLDQERRMLVKVFGVCLCHTRDEHL IENKLDLIVALAKGEKADKHAPTEEYERLMQDYAEALGYASVEHLDRVMGKLTALVIDDGAVKKSSSFFANLN------- ----FIKDSARELEAYKLKVLALQSLHVIVGRAPKDAIAQHYT--DAVVRYLIAQFDS-KELFVRQL------------- ---------------------VLKTLLALTAVLSPSDGDERLASERNRADLHRICMTITADSANEYLPLLPSIIQLATVL VQLSAEEQNLDVNG--LLNAICFYFFTTAQNLKSRLDTTEDDARTSYLAR-----FLNRSLPEVNQFIRTVLVQQNASPA CLDDVHSILEKWLKDRNGEVRICACHVYNSTLEVYMRS----------------------------MKIGCEAPSKFNQT GSMLGKMVPRCIDSNATVRQTAVDVLKKILEIACVY-ETLTVA--DSSVEWVG----------------------ELDRI RDEIVTDDAKDIYRLAAELARIIAQRLSSYQYVQFSKC---------LLYSVSDPEP-SSVIGASYVLKFFMHVKGSEMF HAIPELVKECLYAV----KICE-VPRAKTTILKSILALTKHHPKLVCNE---ILTQCLPLEEHVIEYWKTLTMDAD-LSG IILDNFIGAVTSTCLYEQPQQQQQQQPDPT-DDAARTATLHPFAIVCVLREMFACAELKSEMQSRFPEIFCMLLSTLASY ITLLPPYSVLAQPNAAGNVTIPKGGSRRGAKANGAPGGTGKEAAAAKLSPCQIVLDAFQ---------TFLDTLGMQQIS LVLAVCPDLAASTDLNSFIEILTPLGVATASEVGINSALMRQLVTTMSRYV--SSPYDTQRIASTGFYAHLVPLQP---- ----YGETASVIMLSLESSLNDPNPLVRGLSIRGLAYVCSLTRHDIDKYATMC--------------LTSLLKGIEDYNE RCFINIPLDSMRGLSRVLQAIEPAKFEPFQVSSAIRIRPFFEKSSTELRESAILLFGDLCGLKLKQLPAGEAGQHDGADV SESLVEQLRANLCSLLLHLCEQNSMIA-RACKITLKNVCALLGTAKMNALAQNHLLEHG--QLQCAVFLKDFVKLIGEEL QEWINDFIDACLPLLRSQWPEIRGNAAILIG------LLHCQNANVKCQHMEQIGH------------------------ -------------------------------------------------------------------------------- -----------------------KISLLLKDECTTVRVSASEALGYIYGEM----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Capitella_teleta_MROH5 -------------------------------------------------------MALIDAQLDKDSNVRDVVGASLRDL GSKQTSLVLTSCLNYLSKHVKLPVAHKIAILNCMADVVR--ANLEKVDKELAIAIVKEAATQMTQTKDAVPEWQAAASHV LVAVGC---QWILESNTELIKRFNPGQ-LPDFFIVETMGNLAKENVYGMVPYIKAGLSTMLSVIGIAKQDNIRWIFAYTI SRFCEAILDYCANMDNFDSDPNVNIAFYS-----DEIDVI-----------HEVLLNNWIGTRDAKIREQVIEAVGQMSY VVSKPKLQERLPKLLQTFSNLYKKHP--EPFHVSKGLYNILDANSSD---ILHPHVESILQAIFPQV---CHAVDYSVPM TIKNHNELLRCLS--VLVRVDSMLVVMFLMEKLENSNERVRIGVLSIMRHLINSAGEEMADKKDIFISGLKKVTGDPNNK VKKILA-QTIIAMAHHGYLQLVGGQEMIEFIVNQCAL-PTE-TPGRRPTDPEYVSNDALRSMCDNVLQLLTTTVDNMGKV LWPFLLECVIPEKYTMAQSTICRCIAHTAAKKKEENDDSFYVDFD---------------------------ASANVPKP QALLARFFVLCGLPVQSKHRGLHALTALRWLAPLIHENLIEMWDIVIPKLIKHLE-----DHQDLDD-WSQNNWEDLMLK FVSKSLEQVGDEEWICSMGDAMAEQ----------------------ISLYDNLHDE---KNFLYKCLGIIMRISSKKDF VSHHLDTLFSTVKHA----------NQVEREGCAVGLGYAAASHLDIVTTKLDLIAKRKSDSTRKSGILS---------- ---FIKDFGSGSELDDQTKATILLCYGYVALYAPPHLIISRLQT--QILVAINPHLTNAKLLLLSPPLPSQDPD------ -----------------VKQNLIRTIELIGRSMHPEHLNARHDFSHKNKLLQHLQDYIKAESP--TQVTGETRYLAFKAM CVLVQLTPRLMSSELAALLQNVLDASMQLPPLPP-------NADAKDSEL-----LLSNTLKSLQQLLLDILSTEMTTKG LDIICTALQ-PWRVSSHSHERERAMELSLKIYHHFLQGV---------------------------DVVSVSSLLAFCSQ GSCLGRIVPRCSDPQDDVRESAFNCIYTLLKIKKHAYFSFPRKRPDYSDPFVE----------------------SVNEL KHKIDVEDSAGLFEVISQLAEVLRQKLSSDQLMPFLQV---------LMEGLVDAEP-FCSSGACVVMKSFMESRGAELH SQVATLQTGLHAKL----SVIT-HPQTRTGTLRAVRALGKHHMLTMLEH---LMQRTLPLDAATLDTWKVIGQKAS-LTA AFMETALEMLRQALPYEERSD---KERVI---RSATQHSMALT---VVLTELCKGEEAAPVVASNYARLLASMMTMVS-- -----------SMVDVRPPQQQA-----KDANGKPAKHS-SALTTARIDPSEVSIDGLR--------QVLIA-SQCPAIM QALDSVEIWGKFRNIEQVADGFALLTKCLVEFQPH--CIGHLVSNLNPLLG--ASVYDPQRMMAAAVYAQVISERSLIEE GCAGDSNLVDLLVNGLLARLVDSNHRVRMLCIRGLGNVASAGSEQLRKYSMSV--------------VSAMIAGMDDKED VDDY-ITLEAMEGLSRILAEIDEEQIRGVLINVSLRIRPCFEKNNDRVRAVAIGLFGDLARFGDG-------------PS KDPFVEQIHSNLVTLLLHLNDPSPQVR-LACKKTLRSIGPFVGSEAINEMFQKHLLESA--SLIYGEFMNDLSKAINKDF VDKLNFYTMGNVSFFRSSWSEIRSNAAMFVG----FLLGNMDSSSASNLSKEHICG------------------------ -------------------------------------------------------------------------------- -----------------------ALILLLKDLSPDVRIKAAEAMSYLHCI------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Homo_sapiens_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MAGGVWGRSRAREA----PVGALT-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------LTALTEG--IRARQGQPQGPP------------------------------SAGPQ-PKSWEVKPE AEPQTQALTAPSEAEPGRGATVPEAGSEPCSLNSALEPAPEGPHQ----------------------------------- -----------VPQ----------SSWEEGVLADLALY----------TAACLEEAGFAGTQATVLTLSSALEARGERLE DQVHALVRGLLAQV----PSLAEGRPWRAALRVLS-ALALEHARDVVCA---LLPRSLPADRVAAELWRSLSRNQRV-NG QVLVQLLWALKGA------------------SGPEPQALAATR----ALGEMLAVSGCVGATRGFYPHLLLALVTQLHK- -----------LARSP-CSPDMPKIWV-----LSHRGPP-------HSHAS-CAVEALK---------ALLTGDGGRMVV TCMEQAGGWRRLVGAHTHLEGVLLLAS-AMVAHA-DHHLRGLFADLLPRL---RSADDPQRLTAMAFFTGLLQSR----- -PTARLLREEVILERLLTWQGDPEPTVRWLGLLGLGHLALNRRK-VRHVSTLL------------------PALLGALGE GDARLVGAALGALRRLLLRPRAPVRL--LSAELGPRLPPLLDDTRDSIRASAVGLLGTLVRRGRGG---------LRLGL RGPLRKLVLQSLVPLLLRLHDPSRDAA-ESSEWTLARCDHAFCWGLLEELVT-VAHYDSPEALSHLCCRLVQ------RY PGHVPNFLSQTQGYLRSPQDPLRRAAAVLIGFLVHHASPGCVNQDL-------LDSLFQ--------------------- -------------------------------------------------------------------------------- -----------------------DLGRLQSDPKPAVAAAAHVSAQQVAMLARARGCPRGPRLLRIA----P--------- -------------------------------------------------------------------------------- RPARPPPVFADSPFQRRSVAGRWGCSGPRRA------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Macaca_mulatta_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------PVLSTARLSLCC---PVK------------------------- ----------------------------------------ATR----ALGEMLAVSGCVGATRGFYPHLLLALVTQLHK- -----------LACSP-RSPDMPKIWV-----LSHRGPP-------HSHAS-CAVEALK---------ALLTGDGGRMVV TCMEQAGGWRRLVGAHTHLEGVLLLAS-AMVAHA-DHHLRGLFADLLPRL---RSADDLQRLTAMAFFTGLLQSR----- -PTARLLREEVILERLLTWQGDPEPTVRWLGLLGLGHLALNRRK-VRHVSTLL------------------PALLGALGE GDSRLVGAALGALRRLLLRPRAPVRL--LSVELGPRLPP----LLDDIRASAVGLLGSLVRRGRGG---------LRLGL RGPLRKLVLQSLVPLLLRLHDPSRDAA-ESSEWTLARCDQAFCWGLLEEMVT-VAHYDSPEALSHLCRRLVQ------RY PGHVPNFLSQTQGYLRSPQDPLRRAAAVLIG------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Callithrix_jacchus_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MARGVWG--WVPEM----PMGALT-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------LTAVAEG--IRARQGRSREPP------------------------------STGPQ-PEPWELKPE AEPQAQAIATHSETESGCGATIPEAGSEPR--------SPERPHQ----------------------------------- -----------VPQ----------SSWEEGVLADLALY----------TAACLEEAGFAGTQATALTLSSALEARGERLE DQVHALVRGLLAQV----PSLAEGRPRRAALRVLS-ALALEHARDVVCA---LLPRSLPPDRAAAELWR-LSCNQRV-NG QVLVQLLWALKGA------------------SGPEPQTLAATR----ALGEMLAVSGCVGATRGFYSHLLLALVTQLHK- -----------LARSP-RSPDMPKIWV-----LSHRGPP-------HSHAS-CAVEALK---------ALLTGDGGRMVV TCMEQAGGWRRLVGAHTHLEGVLLLAS-AMVAHA-DHHLRGLFADLLPRL---RSADDPQRLTAMAFFTGLLQSR----- -PTARLLREEVILERLLTWQGDPEPTVRWLGLLGLGHLALNRRK-VRHVSALL------------------PALLGALGE GDARLVGAALGALKRLLLRPRAPVRL--LSSELGPRLRPLLDHTRDSVRASAVGLLGTLVRRGRGM---------LRLGL RGPLRKLVLQSLVPLLLRLHDPSPDAA-ESSEWTLARCDQAFCWGMLEEMVT-VARYDSPEALSHVCRRLVQ------RY PGHVPNFLSQTQGYLRSPHDPLRRAAAVLIGFLVHHASPGCVNQDL-------LDSLFH--------------------- -------------------------------------------------------------------------------- -----------------------DLGRLQNDPEPAVAAAAHVSAQQVALLARSRG------------------------- -------------------------------------------------------------------------------- ---RPRPVFANSPFQRRSLAGRWGCSGPCRA------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Mus_musculus_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MAGGVWGRGRDGRDG---PVGSLT-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------LTALAEG--IRASQGQPVGPS------------------------------STGPQ-SDPQELGPE PEPYIQTLTPAFEAQPGNEVVAPTAGSEIYSPHNAQEPAPERPYQ----------------------------------- -----------ASQ----------YSWEEGTLADLALY----------TAACLEEAGYAGTQATALTLSSALEARGQRLE DQVHGLVRGLLAQV----PSLAEGRPRRAALRVLS-ALALEHAQDVVCA---LLPSSLPPDRAASELWRSLSRNQRV-NG QVLVQLLWALKGV------------------AAPESEALAATR----ALGEMLAVSGCVGATRGFYPHLLLALVTQLHE- -----------LAQGA-HSPDSPKVWE-----PSHRGPP-------HSHAS-CTVEALK---------ALLTGDGGRMVV TCMEQAGGWRRLVGAHTHLEGVLLLAS-AMVAHA-DHHLRGLFADLLPRL---RSANNPQRLTAMAFFTGLLQSQ----- -STARLLREEVILERLRTWQGDPEPTVRWLGLLALGNLAMNRGK-IRHVNMLL------------------PVLLRALGE GDVRLVGAALGALRRLLLQPGAPVRL--LSSELRPRLPPLLDDARDSVRASAVGLLGTLVRRGQRG---------LRLGL RGPLRKLVLQSLVPLLLRLHDSSQDAA-ESSEWTLARCDQALRWGLLEEMVT-VAHYDSPEALSRVCHRLVQ------RY PSHVQYFLSQTQGYLRSPQDTLRRAATVLIGFLVYHTRPKGISQDL-------LDSLFQ--------------------- -------------------------------------------------------------------------------- -----------------------DLGQLQGDPESAVSSAAHVSAQQVALLARAQVQTRSPNLFRFI----R-R------- -----------------------------------------------------------------------------HHS YPPRPHPLYDDSPFLRRSLAGRWSCLEPH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Rattus_norvegicus_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MAGGVWGRGRDG------PVGSLT-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------LTALAEG--IRASQGQPVGPS------------------------------STGPQ-AEPEELGPE AEPYIQTLTPASEAQPGNEVVAPTASSEIGSPPNVQEPAPERPYQ----------------------------------- -----------VSQ----------YSWEEGTLADLALY----------TAACLEEAGYAGTQATALTLSSALEARGQRLE DQVHDLVRGLLAQV----PSLAEGRPRRAALRVLS-ALALEHAQDVVCA---LLPSSLPPDRAASELWRSLSRNQRV-NG QVLVQLLWALKGA------------------AGPESEALAATR----ALGEMLAVSGCVGATRGFYPHLLLALVTQLHD- -----------LAQGA-HSPDSPKVWE-----PSHRGPP-------HSHAS-CTVEALK---------ALLTGDGGRMVV TCMEQAGGWRRLVGAHTHLEGVLLLAS-AMVAHA-DHHLRGLFADLLPRL---RSANNSQRLTAMAFFTGLLQSQ----- -PTAQLLREEVILERLRTWQGDPEPTVRWLGLLGLGHLAMNRGK-IRHVNTLL------------------PVLLRALGE GDVRLVGAALGALRRILLQPGAPVRL--LSSELRPRLPPLLDDARDSVRASAVGLLGTLVRRGQRG---------LRLGL RGPLRKLVLQSLVPLLLRLHDSSQDAA-ESSEWTLVRCDRALRWGLLEEMVT-VAHYDSPEALSRVCHRLVH------RY PSHVQHFLSQTQGYLRSPQDTLRRAATVLIGFLAYHTSPKGVSQDL-------LDSLFQ--------------------- -------------------------------------------------------------------------------- -----------------------DLGQLQGDPESAVSSAAHVSAQQVALLARAQVQTRSSNLFRFI----RHR------- -----------------------------------------------------------------------------HRS YPTRPHPLYDDSPFLRRSLAGRWSCLEPR--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Bos_taurus_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MAGGVWGPARGA------PVGALT-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------LTALAEG--IRASRGQPMGPP------------------------------APGPQ-PQP-ELEPA VEE------------PGRAATTPTAGGEPPSPPPPQEPAPEGPQQ----------------------------------- -----------TPR----------SSWEEGALADLAVY----------TAACLEEAGFVGTQATALTLSSALEAQGHRLE DQVHGLVRGLLAQV----PHLAEGRPRRAALRVLS-SLALEHSRDVVFA---LLRCSPAPDRVAAELWRSLSRNQRV-NG QVLVQLLWALKGS------------------AGSQLEALAATR----ALGEMLSVSGCVGATRGFYPNLLLVLVTQLHE- -----------LARDA-HSPDTPKVWV-----PSHRGPP-------HSHAS-CTVEALK---------ALLTGDGGRMVV TCMEQAGGWRRLVGAGTHLEGVLLLAS-ALVAHA-DHHLRGLFADLLPRL---RSTDDAQRLTAMAFFTGLLQSR----- -PTARLLREEVILERLRAWQGDPEPTVRWLGLLGLGHLALNHGK-VRHATTLL------------------PALLGALGE GDPRLVDAALGSLRRVLLQPRAPVRL--LSAELRPRLPPLLDDTRDSVRASAVGLLGTLVRRGRGG---------LRVGL RRPLRKLVLQSLVPLLLRLHDPSPDTA-ESSEWTLARCDQALHWGLLEEMVT-VAHYDSPEALSRICHRMVQ------WY PSHVPSFLSQTQGYLRSPQGPLRRAAALLTGFLVHHSSPSHVNQDL-------LDSLFQ--------------------- -------------------------------------------------------------------------------- -----------------------DLGRLRSDPEPAVAAAARVSGQQVALLARAQPQPCGRSLWGLRHLPCPGR------- -----------------------------------------------------------------------------PRP RPARPPPVYADSPFQHRSHPGRWGCSGPG--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Pteropus_vampyrus_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MAGGVWGRARGA------PVGALT-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------LTALAEG--IRASQGQPVRPP------------------------------PKGPQ-PEPEPTEAE ---------------PGNITASP----EPCSPPREQEPASERPHQ----------------------------------- -----------VPQ----------SSWEEGPLADLALY----------TAACVEEAGFMGTQATALTLSSALEARGERLE DQVRALVLGLLAQV----PSLAEGRPRRAALRVLS-ALALEHAQDVVRA---LLPCSLPPDRAAAELWSSLGRNQRV-NG QVLLQLLWVLKGT------------------AGLELEALAATC----ALGEMLAVSGCVGATRGFYPHLLLTLVTQLHR- -----------LARGA-HSPDTPKIWA-----PSQRGPP-------HSHAS-CTVDALK---------ALLTGDGARMVV TCMEQAGGWRRLAAAHTHLEGVLLLAS-AMVAHA-DHHLRGLFAELLSRL---CSPDEAQRLTAMAFFTGLLQSG----- -PTARLLREEGILERLRAWQHDPEPTVRWLGLLGLDHLALNNGK-ARHVSALL------------------PALLGALGE ADARLVGAALGALRRVLLQPRAPVRL--LSTELGPRLAPLLDDARDSVRASAIGLPGTLVRQGRGG---------LRVGL -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Monodelphis_domestica_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MARGRRGWGGGEPRGQAGPLGALT-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------LAALAEG--IQISRG-ATGPS------------------------------QGQPP-QEPKEPENP TEAVTTPRTEGLEPDPATGDLKNEPCSSKAS-SSESEPQPWEPEQ----------------------------------- -----------HPQ----------CLLAPGSLADFALQ----------TVVCLEDAGISGTHALAFSLSSALEAQGGQLP EKVREVVQGLHGQM----AQLVEGRARRVALRALC-SLAAEHTQEVVQT---LLPHSLPCDRAAAELWRGLSRNQRV-NG LVLVHLLQEVKGPPQSQGLSPSSSPGPSRQDAKPHTQALAATR----ALGEMLSVSGCVAATRGFYPQVLIALVTQLHQ- -----------LAWGV-HSPQAQ---------VKVRGPP-------SNHAS-CAVEALK---------ALLSGDGGRMVV TCMEQSGGWRRLMGSGTHLEGVLLLAS-ALVAHA-DHHLRGLFADLLPRL---QSPDKAPRLTAMAFFTGLLQSQ----- -PTARLLRDEAIVQRLTAWQGDPEPTVRWLGLLGLGHLALNHRK-ARHVGTLL------------------RALLDALGE ADTRLVGAALGALRRLLLRPRARARVSAYCASLGTRLRPLLDHCQDSVRASAIGLLGTLVGR-------------CSLRR ARMVRELVLGSLVTLLLRLQDPSLDAA-QSAEWTLARCDRFLHWKLLEEIST-MAHYDSPEALSRTCGRLVQ------WY PRRASDFLSQAQGYLRSPEVPIRRVAAMFIGFLIHHMDPDCVNPGL-------VDSLLH--------------------- -------------------------------------------------------------------------------- -----------------------DLGEMQWDAETCIRDVSHITMHQVRLVCQDQDSPGHGNFSPWQLFCCWG-------- -------------------------------------------------------------------------------H HQERERPVYEDSPFKPRSRAGLWGCGRPS--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Anolis_carolinensis_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------MNSFYVSVIIFLVIQLHY- -----------LVDCSDIDYGQEEILQ-----------T-------SSYIS-CTMETLK---------ALVKRETTSRAC FAS-LTGSWDLLSSPENYLEGVLLLAR-ALVKHH-RGLDYAVFTKVIPLL---HHGDDKQKLTAMAFFTALLSSE----- -STYTVLQKHYSLGLLKNWLADSSATYRWLSLHGMGNVAHHLQS-KKEFTTLI------------------LSILPSFDD SDEKVALTAMEVITKVMVQQKINVNLY---VKITKQLQPFLADGRNKVSCAANKLFQDILKN-------------IDAKD KYAMQDQVLTAIVTLMVNLQELNLDVAKESGSRWLLVVTTSFSCWLQESFNG-WTTNDNEDSWDMVCKHLVK------EH PGKLRRLLNQAQHYRQSPQKSSRSAATIFIG------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Hydra_magnipapillata_MROH6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MASELLGGNKYVSSSVVIPIVCHLSREMVIQDDYPRYITLFK---------- ---------------------------EKFVNEMERRFKDFLNDTSNERSNIWQKLSELLESVLDIRPVS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -IQQKPKVKMDSYTKDYSYSSIRRKAKKQAELDLN-------------------------------------TTTDFNLQ SNFSSETIRDLNFANDNVNDIDSEENNYVSSSSDNQDENFDGEIN-------------------------------NILR DWSLQYNITHVALASLLCILKPYFPTLPQHPRTLLKTP----------TILEVKKLKSGGDYCHIGLENGLKNCINDLFI PENTNIHLQINIDG------LPLFKSSGVSVWPILCIVKNFSMKEPFVVG-IYSGKEKPPSAAEFLEEFVEETKHLVDNG FLFNNKRYSVKIHSFICDAP-----------ARAFVKGIKGHSG---YNSCEKCATNGEYDGKLIYPETNAPLRTDLSFF H-------------------------------------------------------------------MIDKKHYLWECP LKLLNVGFVSQFGLDYMHLVCLGVMKRLILYWKGPKGPLHVRIGTRAMDQLS-NSLNSLSQNIPSEFSRKCRSAH----- ----EVLRWKATKFRLFLLYLGPLVLSNVLSLPLYNHFMLLNVAITILVDPVFS--------------------KDYSEY AHELLVLFVNEGKSLYGKGFLVYNVHCLIHLSKDVQTLGPLDNFSSFPFENLLGQLKKMIRKPQFP-------------- IQQLVRRLGERKLSSNLKNDNNLDELNLLKGEHFNGPLPNGFEHAKQFKKVQLEKWFFSTSNKDNCFITNDG-------- ---VPCIIRNMLLINNDITFVCEKFLTVYESFMFPISSTKLGICKVS--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Homo_sapiens_MROH7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MALSPGANLVFHEDPKMTPSP PSCGAPGLGSGTIPQPHPDMAQVPMLNLLPSPGLALVPDLNDSLSPVSGEASGLVSENTPRPDDSRAIAPASLQITSSCS GEALDLDSKDVSRPDSQGRLCPASNPILSPSSTEAPRLSSGNHPQSNSEDAFKCLSSKIFKLGQRNSNPSRHELNPFIRH HSREGLVLG-------HCISRPSSKALLIPTSNSSLDLDSNPLLNMGSRNTSKLNLNVAPDSHGTLIPDTNETITLASHN ISESVSKGAFSTTWSTSSKETMNVASSGHSRSDLSVTITQASYVT--------------------------LIPGSSYGI SLHSSTHEPNST-----ISPPSCMTLILGSNETLSLDSSLLFSDTSTLTLSSQQDDAKDNSIHTVPLEENLESWSEMASI KVGQFPLGFPISNPAGKDAVTLQGIPEG-----------------------AFDEVTSCLVKVPEKTEGG---NNMALVE NVTTLQKSQDLLEAEGEKKTMIKKIMRQIQEEPLDSLSSSVRKQAMEILTQLSHTQPTLGMRERSELVNVCVH------- --------------------SVFSLPSVQAMQE---KDEAKAETIQALYHQTLEALQTLLKALFIEDPTPAG-------- -------------------------------------------------------------------------------- --------------------------------------------------------LKSILE------------------ -------ALGPWMNSGKAHERARAVNTNVSVLNHMLLTLPFF------------------------------MPLGFPAL GLLLGRLILHIGDPDEEIGCEALDGIIILYTILELQKRARDKEE--------------------------TNKKELYESN KHFLGPYNPVSPCQNILRVIEEFGDFLGPQQIKDLLLAALEGLKGSSE--APGKDSREMMQLASEVMLSSVLEWYRHRAL EVIPEIMQGIYMQL----SHIQEPRARQVALLPVS-LLASSFMTEVVVA---LLMCPLPLNSNGAEMWRQLILCKPSCDV RDLLDLLLGSLKEKPVTKE------------GRASIVPLAAAS----GLCELLSVNSCMGRVRRIYPQLLLALLIQVHYH IG--------LNLPGCVAPPKDTK----KGAQPSPFVP------------VRWVVKVVK---------TLLLRMGCSYET TFLEDQGGWELMEQVESHHRGVALLARAMVQYSCQELCRILYLLIPLLER-----GDEKHRITATAFFVELLQMEQVR-- -----RIPEEYSLGRMAEGLSHHDPIMKVLSIRGLVILARRSEKTAKVKALLP-------------------SMVKGLKN MDGMLVVEAVHNLKAVFKGRDQKLMDSAVYVEMLQILLPHFSDAREVVRSSCINLYGKVVQKLRA-------------PR TQAMEEQLVSTLVPLLLTMQEGNSKVS-QKCVKTLLRCSYFMAWELPKRAYSRKPWDNQQQTVAKICKCLVN------TH RDSAFIFLSQSLEYAKNSRASLRKCSVMFIGSLVPCMESIMTEDRLNEVK------------------------------ -------------------------------------------------------------------------------- ----------------------AALDNLRHDPEASVCIYAAQVQDHILASCWQNSW-LPHGNSWVCYSATTHR------- ------------------------------------------------------------------------------WS PSCENLPTSHQRRSWIMQALGSWKMSLKK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Pan_troglodytes_MROH7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MALSPGANLVFHEDPKMTPSL PSCGAPGLGSGTIPWPHPDTAHVPMLNLLPSPGLALIPDLNDSLSPVSGEASGLVSENTPRPDDSRAIAPASLQITSSCS GEALDLDSKDVSRPDSQGRLCPASNPILSPSSTEAPRLSSGNHPQSNSEDAFKCLSSKIFELGQRNSNPSRHELNPFIRH HSREGLVLG-------HCLSKPSSKALLIPTSNSSLDLDSNPLLNMGSRNTSKLNLNVAPDSHGTLIPDTNETITLASHN ISESVSKGAFSTTWSTSSKETMNVASNGHPRSDLNVTITQASYVT--------------------------LIPGSSDGI SLHSSTHGPNST-----ISPPSCMTLILGSNETLSLDSSLLFSDTSTLTLSSQQDDAKDNSIHTVPLEENLESWSEMASI KVGQFPLGFPTSNPAGKDAVTLQGIPEG-----------------------AFDEVTSCLVKVPEKTEGG---NNMALVE NVTTLQKSQDLLEAEGEKKTMIKKIMRQIQEEPLDSLSSSVRKQAMEILTQLSHTQPTLGMRERSELVNVCVH------- --------------------SVFSLPSVQAMQE---KDEAKAETIQTLYHQTLEALQTLLKALFIEDPTPAG-------- -------------------------------------------------------------------------------- --------------------------------------------------------LKSILE------------------ -------ALGPWMNSGKAHERARAVNTNVSVLNHMLLTLPFF------------------------------MPLGFPAL GLLLGRLILRIGDPDEEIGCEALDGIIILYTTLELQKRARDKEE--------------------------TNKKELYESN KHFLGPYNPVSPCQNILRVIEEFGDFLGPQQIKDLLLAALEGLKGSSE--APGKDSREMMQLASEVMLSSVLEWYRHRAL EVIPEIMQGIYMQL----SHIQEPRARQVALLPVS-LLASSFMTEVVVA---LLMCPLPLNSNGAEMWRQLILCKPSCDV RDLLDLLLGSLKEKPITKE------------GRASIVPLAAAS----GLCELLSINSCMGRVRRIYPQLLLALLIQVHYH IG--------LNLPGCVAPPKDTK----KGAQPSPFVP------------VRWVVKVVK---------TLLLRMGCSYET TFLEDQGGWELMEQVESHHRGVALLA------SCQELCRILYLLLPLLER-----GDEKHRITATAFFVELLQMEQVR-- -----RIPEEYSLGRMAEGLSHHDPIMKVLSIRGLVILARRSEKTAKVKALLP-------------------SMVKGLKN MDGMLVVEAVHNLKAVFKGRDQKLMDSAVYVEMLQILLPHFSDAREDVRSSCINLYGKVVQKLRA-------------PR TEAMEEQLVSTLVPLLLTMQEGNSKVS-QKCVKTLLRCSYFMAWELPKRAYSRKPWDNQQQTVAKICKCLVN------TH RDSAFIFLSQSLEYAKNSRASLRKCSVMFIGSLVPCMESIMTEDRLNEVK------------------------------ -------------------------------------------------------------------------------- ----------------------AALDNLRHDPEASVCIYAAQVQDHILASCWQNSW-LPHGNSWVCYSATTHR------- ------------------------------------------------------------------------------WS PSCENLPTSHQRRSWIMQALGSWKMSLKK--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------- >Pongo_abelii_MROH7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MALSPGANLVFHEDPKMTPSL PSCGALGIGSGTIPQPHPDMAHVPMLNLLPSPGLALVPDLNASPSPVSGEASGLVSENTPRPDDSRAIAPASLQITSSCS GEALDLDSKDVSRLDSQGHLCPASNPILSPSSTEAPGLSSGNHPQSNSEDAFKCLSSKIFELGQRNSNPSRHELNPFIRH HSREGLVLG-------HCISRPSSKALLIPASNSSLDLDSNPLLNMGSRNTSKLNLNGAPDSRGTLIPDTNKAFTLASHN ISGSVSKGAFSTTWSTSSKETMNVASNDHPRSDLNVTITQASYMT--------------------------LIPGSSDGI SLHSSTHGPNST-----ISPPSCMTLILGSNETLSLDSSLLFSDTSTLTLSSQQDDAKDNSIHTVALEENLESWSEMASI KMGQFPLGFLTSNSAGKDAVTLQGIPEG-----------------------AFDEMTSCLVKVPEKTEGG---NNMALVE NVTTLQKSQDLLEAEGEKKTMIKKIMRQIQEEPLDSLSSSVRKQAMEMLTQLSHTQPTLGMRERSELVNMCVQ------- --------------------SVFSLPSVQAMQE---KDEAKAETIQTLYHQTLEALQTLLKALFIEDPTLAG-------- -------------------------------------------------------------------------------- --------------------------------------------------------LKSILE------------------ -------ALGPWMNSGKAHERARAVNSNVSVLNHMLLTLPFF------------------------------MPLGFPAL GLLLGRLILRIGDPDEEIGCEALDGIIILYTILELQKRARDKEE--------------------------TNKK