>HUMAN_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEQ------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRYREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLVQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDI-------E ACVSGQTKYSVEEAIHKFALMNRRFPEEDEEGKKEND-IDYDSESS-SSGLGHSS------------------------- ---------------------------------------DDSSSHGCKVNT----------------------------- ----------------------------------------------APQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >MOUSE_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEQ------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRYREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLVQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDI-------E ACVSGQTKYSVEEAIHKFALMNRRFPEEEEEGKKDAD-VEYDSESS-SSGLGHSS------------------------- ---------------------------------------DDSSSHGCKTSP----------------------------- ----------------------------------------------ALQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >RAT_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEQ------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRYREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLVQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDI-------E ACVSGQTKYSVEEAIHKFALMNRRFPEEEEEGKKDTD-VEYDSESS-SSGLGHSS------------------------- ---------------------------------------DDSSSHGCKTSP----------------------------- ----------------------------------------------ALQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >DOG_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEQ------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRYREFVWLRQ-RLQNN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLVQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSCLHLFLQSHLNSEDI-------E ACVSGQTKYSVEDAIHKFALMNRRFPEEDEEGKKEND-IDYDSESS-SSGFGHSS------------------------- ---------------------------------------DDSSSHGCTMST----------------------------- ----------------------------------------------APQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >COW_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEQ------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRYREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLVQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDI-------E ACVSGQTKYSVEEAIHKFALMNRRFPEE-EEGKKEND-IDYDSESS-SSGFGHSS------------------------- ---------------------------------------DDSSSHGCKMST----------------------------- ----------------------------------------------APQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >PLATYPUS_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEH------- -----------KKAEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRFKEFVWLRE-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLIQLPELPSK-----TPFFNINNRQHVDQRRQGLEDFLKKILQNALLLSDSRLHLFLQSHLSSEDI-------E ACVSGQTRYSVAEAIQKFASSNRRFPEEDGERKKEKNYLDSDSESS-SSGLGHSS------------------------- ---------------------------------------DDSISHGCEIST----------------------------- ----------------------------------------------APQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >OPOSSUM_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MKPEKRHREGPRRLLCLR IIVSCWTGKTDPSVHWAEGTSPGLPGQPRPSSLRMETGLLLAACGPGRPVVSGHGEDSGKVIKTNFCQMEPASSSGKQKA LLVRGDPERLRKWEEFVSVWVRDPRI--------------------------------------QKEDFWHSYVD----- -----------------------------------------------YEIFIHTNSMCFTMKT----------------- SCVRRRFREFVWLRE-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLIQVPELPSK-----TLFFNINNREHVDQRRRGLEDFLRKILQNALLLSDSRLHLFLQSHLSSEDI-------E ACVSGQTRYSVSEAIQKFASSNRRFPKEDDEGGEKDNSIDYGSKSS-SSGLGHSC------------------------- ---------------------------------------EDSSPHGCKTSP----------------------------- ----------------------------------------------ALQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >HORSE_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEQ------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRYREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLVQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSRLHLFLQSHLNSEDI-------E ACVSGQTKYSVEEAIHKFALMNRRFPEEDEEGKKEND-IDYDSESS-SSGFGHSS------------------------- ---------------------------------------DDSSSHGCKMSP----------------------------- ----------------------------------------------APQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >CHICKEN_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MTPKH------- -----------EKQEFVTVLVRDPRT--------------------------------------QKEDSWHSYID----- -----------------------------------------------YEIFIHTNSMCFTRKT----------------- SCVRRRFREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AVLIQLPELPSK-----TPFFNMNNPHHVDHRRQGLQEFLEKILQNALLLSDSRLHLFLQTQLSPEDM-------E ACVCGQTKYSVADAIQKFASLNRRFPIEDEERKKGRNDADSDSESS-SSGLGPS-------------------------- ---------------------------------------DDSISCGCKASL----------------------------- ----------------------------------------------ASEES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >ZEBRAFINCH_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MTPKH------- -----------EKQEFVTVLVRDPRI--------------------------------------QKEDSWHSYID----- -----------------------------------------------YEIFIHTNSICFTRKT----------------- SCVRRRYREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AVLIQLPELPSR-----TPFFNMNNPNHVDHRRQGLQEFLEKILQDALLLSDSRLHLFLQTQLSPEDM-------E ACVSGQTKYTVADAILSFASLNRRFPIEDEEEKKGKDDADSDSESS-SSGLGPS-------------------------- ---------------------------------------DDSISCGCKASP----------------------------- ----------------------------------------------ASEES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >ZEBRAFISH_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------MDNTS------------------ -------------------------------------------------------------------------------- ----------FEKREFISVWVRDPQV--------------------------------------HKEDFWHTYIS----- -----------------------------------------------YEICLHTNSMCFRKKT----------------- SCVRRRYSEFVWLRH-KLQDN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLIELPKLPPW-----NPFFNLNNEFHITQRMQGLQQFLEAVLQTPLLLSDSRLHLFLQSQLSIAKM-------D ACAQGHTHYTVAQAIQRCGG-EARFPVEEQHQEDSKTCCDSDCDSTTSSGLGCSI------------------------- ---------------------------------------EPATLVEQDLSH----------------------------- ----------------------------------------------NERFAHEFQATNPEAE------------------ -------------------------------------------LCSSLSSSPHGHSVI---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >FROG_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MLPRD------- -----------QEGETISVWVRDPKV--------------------------------------QKED-WHSYVD----- -----------------------------------------------YEICVHTNSMCFTLKT----------------- SCVRRRFREFVWLRQ-KLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AVLTQLPELPPR-----IPFFKISNSQNLEHRVRGLQEFLNKVLHCSVLLSDSRLHLFLQTQLSTEEI-------D ACASGKTEYSVFEAIHKFANSNRRFPAEEEE--KTSHYLDPES------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >MEGABAT_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEQ------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRFREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLIQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSRLHLFLQSHLNSEDI-------E ACVSGQTKYSVEEAIHKFALMNRRFPEEDEEGKKEND-IDYDSE------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >MICROBAT_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MLPEE------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRYREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLVQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLHNALLLSDSSLHLFLQSHLNSEDI-------E ACVSGQTKYSVEEAIHKFALMNRRFPEEDEAGEQENN-IDYGSESS-SSGFGHSS------------------------- ---------------------------------------DDSSSHGCNMST----------------------------- ----------------------------------------------APQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >ARMADILLO_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEQ------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRYREFVWLRQ-RLQNN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLVQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDI-------E ACVSGQTKYSVEEAIHKFALMNRRFPEEDEERKKEND-IDYDSESS-SSGLGHSS------------------------- ---------------------------------------DDSSSHGCKIST----------------------------- ----------------------------------------------APQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >ANOLELIZARD_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------QEFVTVLVRDPQL--------------------------------------QREDYWHSYID----- -----------------------------------------------YEIFIHTNSMCFTRKT----------------- SCVRRRFREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AVLIQLPELPPK-----TPFFNTNNPQHVDQRRQGLQEFLQKILQNPLLLSDSRLHLFVQTQLTPEDI-------E ACVSGHTKYSVAEAIHQFACLKRKFPVEHEEIKKEENSADSDSESS-SSGLGHSS------------------------- ---------------------------------------DDSNSHGCKGS------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >RABBIT_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGFSCKMSETQE------ ------------QEEVITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----SAFFG-SSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEI-------E ACVQGRSSVTVSEAILRYAMSNCGWAQEERQSSSHLATGDQPRSCCFLPRSGRRS------------------------- ---------------------------------------SPSPP-SEEEDR--------------L-------------- -----------------------------------EGWAPAVDSEAPSLEGASVAPL----------------------- -------------------------------------------SSPSCCGSARRADRAS--------------GPVGRDC AVPLDPGQLETLREK----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >FUGU_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQQVVSIWVRDPRL--------------------------------------QKNDFWHAYID----- -----------------------------------------------YEICLHTTSVCFTKKI----------------- SCVRRRYSEFVWFRQ-KLKANS---------------------------------------------------------- -------------------------------------------------------------------------------- ----MPTTKLPDLPPK-----NPFFSLNNAQQITERMVGLQKFLEEILQDPLLLSDSCLHLFLQTQLSVSKI-------E ACAAGRTHYSVVQAVQGYG--LRRFHSTEDLQNSLSTSCDSDSDRCLQPGSTYLF------------------------- ---------------------------------------NLV-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >MEDAKA_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------CVPA------------------ -------------------------------------------------------------------------------- ----------FSMQQAISVWVRDPRI--------------------------------------QKNDFWHAYID----- -----------------------------------------------YEICLHTDSVFLTKKT----------------- SRVRRRYSEFVWLRQ-KLQENA---------------------------------------------------------- -------------------------------------------------------------------------------- ----LLMVKLPELPPK-----NPFFSLNSAQQITERMKGLQTFLEQVLQSRLLLSDSCLHLFLQSDLSVSMI-------E ACAAGRTNFSVAQAVQRSG--LRRFHSEDDLPKEISRSCESDSDSSRSSSAPSEI------------------------- ---------------------------------------LNRCSCSSGVPA----------------------------- ----------------------------------------------EEN------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >STICKLEBACK_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------VSPA------------------ -------------------------------------------------------------------------------- ----------FSMPQVVSVWVRDPRI--------------------------------------QKNDFWHAYID----- -----------------------------------------------YEICLQTDSVCFTKKI----------------- STVRRRYSEFVWLRQ-KLQANS---------------------------------------------------------- -------------------------------------------------------------------------------- ----QLMARLPELPPK-----NPFFSLNSSRQITERMKGLQKFLEQILQNPLLLSDSCLHLFLQSRLSVSKM-------Q ACAAGQTLYSVAQAVQRCG--LRRFRSEEDMQKDPSMSCDSDS------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >TETRAODON_SNX10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MQQVLSIWVRDPRR--------------------------------------QKNDFWHAYVD----- -----------------------------------------------YEICLHTTSVCFTKKI----------------- SCVRRRYSEFVWLRQ-KLQANS---------------------------------------------------------- -------------------------------------------------------------------------------- ----IPMAKLPNLPPK-----NPFFSLNNAQQIAERMKGLQKFLEQILQNPVLLSDSCLHLFLQTQLSVSRI-------E ACAAGRSRYSVAQALQGSG--LRRFHSIDGLQQSPSSSCDCDSDR-------YSH------------------------- ---------------------------------------TLL-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >HUMAN_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGFWCRMSENQE------ ------------QEEVITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----STFFG-TSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEI-------E ACVQGRSTMTVSDAILRYAMSNCGWAQEERQSSSHLAKGDQPKSCCFLPRSGRRS------------------------- ---------------------------------------SPSPPPSEEKDH--------------L-------------- -----------------------------------EVWAPVVDSEVPSLESPTLPPL----------------------- -------------------------------------------SSPLCCDFGRPKEGTSTL--------QSVRRAVGGDH AVPLDPGQLETVLEK----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >MOUSE_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGLWYRMLENQD------ ------------LEEVITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----STFFG-GSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEI-------E ACVQGRGAMTVSDAILSYAMSNCGWAQEERQSTSHLAKGDQLNSCCFLPRSGRRS------------------------- ---------------------------------------SPSPPLSEEKEQ--------------L-------------- -----------------------------------ETWAPVMDSEGPSSESPTLLPSS---------------------- -------------------------------------------SLPACWDPARPEEGLSVS--------QPARRAVAADQ AGPMEPTQLDTAWDK----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >RAT_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MFPEQ------- -----------QKEEFVSVWVRDPRI--------------------------------------QKEDFWHSYID----- -----------------------------------------------YEICIHTNSMCFTMKT----------------- SCVRRRYREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----ALLVQLPELPSK-----NLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDI-------E ACVSGQTKYSVEEAIHKFALMNRRFPEEEEEGKKDTD-VEYDSESS-SSGLGHSS------------------------- ---------------------------------------DDSSSHGCKTSP----------------------------- ----------------------------------------------ALQES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >DOG_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGFWFRMLENQE------ ------------QEEVITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----STFFG-SSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEI-------E ACVQGRSPMTVSDAILHYAMSNCGWVQEERQGSSHLAKGDQPKSCCFLPRSGRRS------------------------- ---------------------------------------SPSPPPREEKDH--------------F-------------- -----------------------------------EN------------------------------------------- -------------------------------------------SLRNCC------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >COW_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGFWCRMLENQE------ ------------QEEVITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----STFFG-SSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEI-------E ACVQGRSPVSVSDAILRYAMSNCGWAQEERRGSSHLAEGDQPKSCCFLPRPGRRS------------------------- ---------------------------------------SPSPPPGEEKDP--------------F-------------- -----------------------------------EVWAPVVDSEAPPLESPTLPPT----------------------- -------------------------------------------SSPSCCGFARPDEGLSAS--------QPVRRVLGGGH AVPLDPGQLETVLEK----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >PLATYPUS_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGSWDRMLENPE------ ------------QEELIAVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----STFFG-NSDEFIEKRRQGLQHFLEKVLQNVVLLSDSRLHLFLQSQLAVAEM-------E ACVQGRGSLTVAEAILRYAMSNCGWAQEEDPGSPRLAMGDLPG-------RLSSP------------------------- ---------------------------------------PPPLQQKEEREA--------------G-------------- -----------------------------------EVRAPADDSQAAPGESQGLPPPSPPQL------------------ -------------------------------------------PSPSSCDFGRSRTRSPVPPSLEWHEEEAEEQPGHPAG VVDSQPGQSEK--------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >OPOSSUM_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MSGLRGYCSRAGGGVWRTGPGEPEWSSTGVPGYLLERPSRGRGQWSRPTVPGDGWSPRMGSSYRMLENQE------ ------------QEELITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----STFFG-NSDEFIEKRRQGLQHFLEKVLQNVVLLSDSQLHLFLQSQLSVPEI-------E ACVQGRSPMTVADAILHYAMSNCGWVQEESMGSPHLAMGDQRKSCCFIRRSSCQA------------------------- ---------------------------------------SSSPLQNEEKDH--------------L-------------- -----------------------------------SVWAPVVDAGAPQVGSSSLPLPT---------------------- --------------------------------------------SSSSWDFVRSDEKTPQP-----WNRAEENHSVHPSY DMDSESGQLETLLRFSRLWLGQHQPPLQLEPKAAAIMLKAYKQQQLGIPIQKRDLDLARRAANSCCIGSYRSDWEWQPWA EAFISWTPTMGFRVEVLWPEIKFKYLRLLLQFVSNKLWRRRRESGLAAVILPYIPSSRSGWNGGGRNVQGLVGMEMDQLS LPFGGRRSIHRKAGVASVDLCVPRIRGLWEPGFVGALAGTGLHHPSPCWPNTRKGSTKPARPPPCRFPARPRQVLAVF >HORSE_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGFWCKMLENQE------ ------------QEEVITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----SAFFG-NSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEI-------E ACVQGRSPMTVSDAILRYAMSNCGWVQEERQGSAHLAKGDQPKSCCFLPRSGRRS------------------------- ---------------------------------------SPSPPPGEEKDH--------------F-------------- -----------------------------------EVWAPVVDSEAPCLESPPLAPS----------------------- -------------------------------------------SSPSCCGLARPDEGLSAP--------QPVRRAVGGDH AVPLDPGQLEAVLEK----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >CHICKEN_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MTPKH------- -----------EKQEFVTVLVRDPRT--------------------------------------QKEDSWHSYID----- -----------------------------------------------YEIFIHTNSMCFTRKT----------------- SCVRRRFREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AVLIQLPELPSK-----TPFFNMNNPHHVDHRRQGLQEFLEKILQNALLLSDSRLHLFLQTQLSPEDM-------E ACVCGQTKYSVADAIQKFASLNRRFPIEDEERKKGRNDADSDSESS-SSGLGPS-------------------------- ---------------------------------------DDSISCGCKASL----------------------------- ----------------------------------------------ASEES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >ZEBRAFINCH_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MTPKH------- -----------EKQEFVTVLVRDPRI--------------------------------------QKEDSWHSYID----- -----------------------------------------------YEIFIHTNSICFTRKT----------------- SCVRRRYREFVWLRQ-RLQSN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AVLIQLPELPSR-----TPFFNMNNPNHVDHRRQGLQEFLEKILQDALLLSDSRLHLFLQTQLSPEDM-------E ACVSGQTKYTVADAILSFASLNRRFPIEDEEEKKGKDDADSDSESS-SSGLGPS-------------------------- ---------------------------------------DDSISCGCKASP----------------------------- ----------------------------------------------ASEES----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >ZEBRAFISH_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MSKSQE------ ------------QDEFIAVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------FKIFLHTNSKAFTAKT----------------- SCVRRRYSEFAWLKK-KLQKN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPKK-----SIFSF-INDDFIERRRKGLQGFLDKVLHMTVCLSDSQLHLFLQTQLPVKHI-------E DCVHGHTPYTVTEAILSYASSNRGWVQEEGGADQELCSTTVSYESVESPVPHLPSLQSPGA---LSSGPPNELTD----- ---------------------------------ASELRLSDTEQTALKTDHEHLPEEKQSYIKLVV-------------- -----------------------------------EVHPNLQGSVETEEDSTTTESEDAEIL------------------ -------------------------------------------VKDTKYPQTYNCESPAPQIDG-SLEDKPLQREKPSKN NLDQEPSFGEDLVDN-TSVDKVIERGTLDNVNDAMKGNQEDSTVGQTSDENIHEEDPRVRIQNNEVTLDLSAIQEDKAEN VPETAVTTMEDVALQVELTENHTIHENGISDEDYSAIQEEAVTEKEDHVGEVNKLNAKCLQASSGILILEGIEEAVSTQT APVTETASNLDANTAEVNTLVLKAIEMDAVQCQETDSQVIIATQQLDAK----------------------------- >FROG_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------MSQDNPD------ ------------EEEFITIRVQDPRL--------------------------------------QNEGSWASYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFDWLRK-RLQKN----------------------------------------------------------- -------------------------------------------------------------------------------- ----SGLVPVPALPGK-----LPFLVGNNDDFIERRRQGLQQFLEQIVQNMVLLSDSQLHLFLQSQLPLSEI-------E ACVLGHRPYTATEAILNYAMSNQGWTQEENPSR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >HEDGEHOG_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGFY-RMLENQE------ ------------QEEVITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTGKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----STFFG-SSDEFIEKRRQGLQHFLEQVLQSVVLLSDSQLHLFLQSQLSVPEI-------E ACVQGRSPMTVSDAILRYAISNCGWVQEERQGSSHLAKGDQPKSCCFPSRSGRRS------------------------- ---------------------------------------SLTPPPGEEKDH--------------F-------------- -----------------------------------AVWAPSVDADASSLENPPLPPP----------------------- -------------------------------------------SSPSHCDFVKLDGETSTS--------QPVRRAMGGDY AVPLDPDQLETILEK----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >MEGABAT_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGFWCRMLENQE------ ------------QEEVITVRVQDPRV--------------------------------------QNE-SWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----STFFG-SSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEI-------E ACVQGRSPMTVSDAILRYAMSNCGWVQEERQGSSHSAKGDQPKSCCFLPRSSRRS------------------------- ---------------------------------------SPSPPPEEEKDH--------------F-------------- -----------------------------------EVWAPVVDSEAPSLESPALPPP----------------------- -------------------------------------------TSPSCCDSARPDEGPSAP--------QPVRRAEGGDH AVPLDPGQLETVLEK----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >MICROBAT_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------EVITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----STFFG-SSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEI-------E ACVRGQSRTTVSDAILRYAMSNCGWAQEERQGSSHLAKGDQPKSCCFFPRSGRSS------------------------- ---------------------------------------SPSTPPEEEKDH--------------F-------------- -----------------------------------EVWAPVVDSEAPSWESPPPLPP----------------------- -------------------------------------------TSPSCCDFARPDEGPCAP--------QPVRRSLGGDH ALPLDPSQLETVLEK----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >ELEPHANT_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MGVWCRMLENQE------ ------------QEEVITVRVQDPRV--------------------------------------QNEGSWNSYVD----- -----------------------------------------------YKIFLHTNSKAFTAKT----------------- SCVRRRYREFVWLRK-QLQRN----------------------------------------------------------- -------------------------------------------------------------------------------- ----AGLVPVPELPGK-----SAFFG-SSDEFIEKRRRGLQHFLE???????????????????????????-------? ????????????????????????????????????????????CCFLPRSGRKN------------------------- ---------------------------------------SPSPPPSEEKDH--------------L-------------- -----------------------------------EVWAPVVDSEVPSLESPTLPAF----------------------- -------------------------------------------SSPSHCDFARPDEGISAA--------QPVRRVVGGDH AVPLDPGQLETVLEK----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >ARMADILLO_SNX11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------