>Homo_sapiens_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MLLAPPSTPSRGRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKTHQVIARRQEPALRG------------- -------------------------------------------------------------SP---GPLTPHPCNELGP- -------------------------------------------------------------------------------- -----------------------PASPRTPRPVRRGSGRRLPRP------------------------------------ -----------------DSLIFYRQKRDCKASVNKE-------------------------------------------- -------------------------------NAKGQG----------------------------------LVRRLFLGA PRDAAPSSP----------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------ASTERPAASGG----------WAAPQDAP---- --------------------------------------------------------------EAAGKRALCPTCS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLERALVEVLG-----------------------------------AERFSPQSWGADASPQA-- GTSPP-PGSGDASDWTSSDRGVDSPGGAG------GGGGSEAAGSARD-------------------------------- --------------RRPPVSVVERNARVIQWLY-GCQRAR--GPPRESEV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Pan_troglodytes_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MLLAPPSTPSRGRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKTHQVIARRQEPALRG------------- -------------------------------------------------------------SP---GPLTPHPCNELGP- -------------------------------------------------------------------------------- -----------------------PASPRTPRPVRRGSGRRLPRP------------------------------------ -----------------DSLIFYRQKRDCKASVNKE-------------------------------------------- -------------------------------NAKGQG----------------------------------LVRRLFLGA PRDAAPSSP----------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------ASTERPAASGG----------WAAPQDAP---- --------------------------------------------------------------EAAGKRALCPTCS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLERALVEVLG-----------------------------------AERFSPQSWGADASPQA-- GTSPP-PGSGDASDWTSSDRGVDSPGGAS------GGGGSEAAGSARD-------------------------------- --------------GRPPVSVVERNARVIQWLY-GCQRAR--GPPRESEV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Gorilla_gorilla_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MLLAPPSTPSRGRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKTHQVIARRQEPALRG------------- -------------------------------------------------------------SP---GPLTPHPCNELGP- -------------------------------------------------------------------------------- -----------------------PASPRTPRPVRRGSGRRLPRP------------------------------------ -----------------DSLIFYRQKRDCKASVNKE-------------------------------------------- -------------------------------NAKGQG----------------------------------LVRRLFLGA PRDAAPSSP----------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------ASTERPAASGG----------WAAPQDAP---- --------------------------------------------------------------EAAGKRALCPTCS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLERALVEVLG-----------------------------------AERFSPQSWGADASPQA-- GTSPP-PGSGDASDWTSSDRGVDSPGGAG------GGGGSEAAGSARD-------------------------------- --------------GRPPVSVVERNARVIQWLY-GCQRAR--GPPRESEV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Pongo_abelii_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MLLAPPSTPSRGRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKTHQVIARRQEPALRG------------- -------------------------------------------------------------SP---GPLTPHPCNELGP- -------------------------------------------------------------------------------- -----------------------PASPRTPRPARRGSGRRLPRP------------------------------------ -----------------DSLIFYRQKRDCKASVNKE-------------------------------------------- -------------------------------NAKGQG----------------------------------LVRRLFLGA PRDAAPSSP----------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------ASTERPAASGG----------WAAPQDAP---- --------------------------------------------------------------EAAGKRALCPTCS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLERALVEVLG-----------------------------------AERFSPQSWGADASPQA-- GTSPP-PGSGDASDWTSSDRGVDSPDGAG------GGGGSEAAGSARD-------------------------------- --------------GRPPVSVVERNARVIQWLY-GCQRAR--GPPRESEV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Mus_musculus_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MLLSSPTTPSRGRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKTHQVIVRRQEPALRG------------- -------------------------------------------------------------GP---GPLTPHPCNELGA- -------------------------------------------------------------------------------- -----------------------SASPRTPGPARRGSGRRQPRP------------------------------------ -----------------DSLIFYRQKRDCKASVNKE-------------------------------------------- -------------------------------NAKGQG----------------------------------LVRRLFLGA TRDAAPSSP----------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------APTERPGAPAG----------WAGSPDTP---- --------------------------------------------------------------EATGKRAVCPTCS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLERALVEVLG-----------------------------------AERFSPQSWGAEHGPQV-- ATSPP-PGSGDTSDWTSSDRDAGSPDCAG------GGGGSEAAGSARD-------------------------------- --------------GRPTVSVVERNARVIQWLY-GCQRAR--APPRESEV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Rattus_norvegicus_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MLLASPTTPSRGRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKTHQVIVRRQEPALRG------------- -------------------------------------------------------------GS---GPLTPHPCNELGA- -------------------------------------------------------------------------------- -----------------------SASPRTPGPARRGSGRRQPRP------------------------------------ -----------------DSLIFYRQKRDCKASVNKE-------------------------------------------- -------------------------------NAKGQG----------------------------------LVRRLFLGA TRDAAPSSP----------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------APTERPGAPAG----------WAGSPDTP---- --------------------------------------------------------------EATGKRALCPTCS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLERALVEVLG-----------------------------------AERFSPQSWGAEHSPQV-- ATSPP-PGSGDTSDWTSSDRDAGSPDCAG------GGGGSEAAGSARD-------------------------------- --------------GRPTVSVVERNARVIQWLY-GCQRAR--APPRESEV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Canis_familiaris_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MILASPSTPSRGRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKTHQVIARRQEPALRG------------- -------------------------------------------------------------GP---GPLTPHACNELGP- -------------------------------------------------------------------------------- -----------------------PASPRTPRPARRSSGRRLPRP------------------------------------ -----------------DSLIFYRQKRDCKASVNKE-------------------------------------------- -------------------------------NAKGQG----------------------------------LVRRLFLGA PRDAPSSSP----------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------GPTERPAAPGV----------WAAPQDAP---- --------------------------------------------------------------EAAGKRALCPTCS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLERALVEVLG-----------------------------------AERFSPQSWGADASPQP-- GASPP-PGSGDTSDWTSSDGDTDRPDGADRGGG--GGGGSEAAGSARD-------------------------------- --------------GRPPVSVVERNARVIQWLY-GCQRAR--GPPRESEV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Bos_taurus_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MLLASPSTPSRGRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKTHQVIARRQEPALRG------------- -------------------------------------------------------------GP---GPLTPHTCNELGP- -------------------------------------------------------------------------------- -----------------------PPSPRTPRPARRGSGRRLPRP------------------------------------ -----------------DSLIFYRQKRDCKASVNKE-------------------------------------------- -------------------------------NAKGQG----------------------------------LVRRLFLGS PRDVASSSA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------GSSERPAAPGG----------WTAPQDAP---- --------------------------------------------------------------EAAGKRALCPTCS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLERALVEVLG-----------------------------------AERFSPQSWGADASPQP-- GTSPP-PGSGDASDWTSSEGGADRRDGA-------EGGGSAAAGSERD-------------------------------- --------------GRPQVSVVERNARVIQWLY-GCQRAR--GPPRESEV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Gallus_gallus_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------MVPLGSTPRAVCTSGRDVSPLRLLNRGPESLRAQLAGGSGGRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKVKYVKSQQVINSRQEPALRGCSP---------- -----------------------------------------------------------CCSPRGRRLLALQRCHELCHG SDLSCDGSR----------------------------------------------------------------------- ----------------------KAPCPSSPVPRRGGGSRRLLRP------------------------------------ -----------------DSLVIYRQKRDCPV-INKE-------------------------------------------- -------------------------------NTKGYG----------------------------------LVRRLFQGP LRDKPPSSPSAQGSDKAPESPMLWVS------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------MEQAEDVRTPGAGGSSSSTVPMPDS--------PVPQPPEAPSLAQ ----------------------------------------------------------PPASPSPSKPALGLRLS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLDRAMVEGLG-----------------------------------KERFVPAGWDAAS-ARLHG SCEWE---PSQASGCSGED-----------------AGPGEEEPDTRL-------------------------------- --------------C-SAISVVERNARVIKWLY-GCQRAW--AAAKESTV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Anolis_carolinensis_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------YLRKQLEGTAGMRTPS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKSQQVIDRRQEPVLLCYSL---------- -----------------------------------------------------------QSSPCCRRPLARHQRLVVTKD GLGPKKLPP----------------------------------------------------------------------- ----------------------TPPSPQSPIARRGGG-RRLLRP------------------------------------ -----------------DSLVIYRQKRDCSA-VNKE-------------------------------------------- -------------------------------NTKSYG----------------------------------IVRRLFQSP LRD----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------GHNSRVVSTEG----------VEHPQRDP---- -------------------------------------------------------------GPTDSKRKLCLSSS----- -------------------------------------------------------------------------------- --LPLSEKERFFNYCGLDRNLVQVLG-----------------------------------AERFKPGTWDARSSGRFPG SVASA---SSLQHG-SGE------------------EGPAEE-PSEKP-------------------------------- --------------S-TSISLVERNARVIKWLY-SCQQAQ--TAAKESTV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Danio_rerio_FAM110D_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MKPLTPIGSPSPLRLLNKGPDYLRRQMDAGSRGRSIS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKTQQVINTKQEPVLVP------------- -----------------------------------------------------------CATP---PPVPRRNLTTSTPS TPVLLPRNQMVPFSAPSFSRDENED-----DSRKENCRNESDVETNNNANKPPVLSP----------------------- --------------------RTPLVAPHSAPIMRRSNGKRMLRP------------------------------------ -----------------DSLVIYRQKKECKSP--GE-------------------------------------------- -----------------------------NINGNIEVKGYS------------------------------FVRRLFQGS MREKSSVNDVAQKTVINEEKASSSRDGDSRMS------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------WSNDKDTVDGGVETRRSSKSEREHSSAEIQNNNEEKQPKICLRNSTRNSN NND---------------------------------------------MDPWKPVIPWKRTNMKRSKSELRLRCS----- -------------------------------------------------------------------------------- --LAISEQERFFDYCGLDFDMVERLG-----------------------------------PENFLAGASSVDTLSLLLR SVGGGG---SEPSEFSRHS-----------------GEGIFQEELAEQ-------------------------------- --------------IPTGVSIIERNARVIKWLY-GCRSAAQ-EGPKESTV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Takifugu_rubripes_FAM110D_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------LPGDSKRINMKPLTPIGSPSPLRLLNKGPDYLRRQIDGGGHGRTIS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKSQQVINTKQEPVLVP------------- -----------------------------------------------------------CATP---PPQPRRGVSLPGNV TPRLPPRSSTTPFSTTSGSLTP-----------KENRRTSVDIEVHNRSNVSFGMPP----------------------- --------------IPRTPGGNSLVAPHSAPVLRRSSGKRMMRP------------------------------------ -----------------DSLVIYRQKKECKSPSGGT-------------------------------------------- ----------------------------VGENNNME------------------------------------SRRSSK-T ERERSPESLPSHAFGSTLERTR---------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------NGFRNGANEGAKTVATNGNHSSNPDDDADDDPWKRASPQPAARR-- ----------------------------------------------------------KFGELRRSKSDLRLRCS----- -------------------------------------------------------------------------------- --VALSEQDYFFDFCGLDMDMIQRLG-----------------------------------RENFLSGASSIDTLSLALR SVVGDGCGGSEPSEFSRHS-----------------GDGLFEEELAEQ-------------------------------- --------------LPTGVSIIERNARVIKWLY-GCKNAAE-EGPKESTV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Gasterosteus_aculeatus_FAM110D_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MKPLTPVGSPSPLRLLNKGPDYLRRQMDGGGHGRSVS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKSQQVINAKQEPALVP------------- -----------------------------------------------------------CATP---PPQPRRAASIPGSP APGLAPRRPSNAASSALSGSFASRDENENYDSRKENRRTSVDVEARNRSNANGALPP----------------------- --------------VPRTPGVGSLVAPHSAPVLRRSTGKRMLRP------------------------------------ -----------------DSLLIYRQKKECKSPHGAA-------------------------------------------- ----------------------------AGDNSNTEG------------------------------------------S TREKA---------AGGEGRIQ---------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------KM-------------------------------------------- --------------------------------------------------------------LRRSESDLRLRCS----- -------------------------------------------------------------------------------- --AALSEQELFFAFCGLDVDMVDRLG-----------------------------------RTNFLSAASSLGTLSLALR SVDGDD--RSEPSEFSQHS-----------------GDGLFQEELAEQ-------------------------------- --------------PPTGVSIIERNARVIKWLY-GCRNAAR-EGPKESTV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Oryzias_latipes_FAM110D_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------SPSPLRLLNKGPDYLRRQIDGGGHGRSIS------ ------------------------------------------------------------------------------AV ERL----------------------------------------------------------------------------- -------------------------------------------EADKAKYVKSQQVINTKQEPVLVP------------- -----------------------------------------------------------CATP---PPHTRRAFSTPGSL TPRLPPRRLSNTPFSISSGSFPSRDENENDDSRKENRRTSVDIEVHNRSNVNYVTPP----------------------- --------------SPRTPGTNKLVAPHSAPVLRKSTGKRMLRP------------------------------------ -----------------DSLVIYRQKKECKSLSDAA-------------------------------------------- ----------------------------AGENNNVDVKGQS------------------------------FVRRLFQGS MREKN---------GGGEGRIQ---------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------KMVIGLGP--TTKMLQTAQEAVKPTKNEVLSVYPALDPDSDLKT-- ----------------------------------------------------------QATELQRSKSDLLLHCS----- -------------------------------------------------------------------------------- --VAFSEQEHFFDFCGLDMDMIERLG-----------------------------------RQNFLSGASSTDTLSLALR SVSEDSGGASEPSEFSRHS-----------------GDGLFQEELAEQ-------------------------------- --------------LPTGVSIIERNARVIKWLY-GCKNAAQ-EGPKESTV------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Hydra_magnipapillata_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MEECEFKEHFRVNRNTFNFLVYELHPLLGKTTTTFREP----- ----------------------------------------------------------------------------ISVV KRV----------------------------------------------------------------------------- --------------------------------------------AVALHYLASCEEYRGVSSLFGIG------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------KSIANLIVHEFINAVN---------------------------------- ------------------DILLPKYVKFPLSVEN---------------------------------------------- -----------------------------------------------------------------------LIKHSRDFE AILG---------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------FQKCIGAVDGCHIP---- -------------------------------------------------------------------------------- IFAPKDQAISYYNYKGWYSIVLFSVVD---------------------------------CRYRFIYTSVGSPGRNNDSY IFQNSSLKAILESSLFDKCC--------------------KELGDS---------------------------------- ---------------LVPLCLIGDSAFPLTRHL-LKPYPKNLELSEI--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Amphimedon_queenslandica_FAM110D -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MDNSVFIGARPGDSEQALSSVVNYSTSKS SFFIVCEIFAIVLQRQTSLLTLTTLAHISSELSIFIDLLPKELLGAVRALCIPNAIYKACATGYSQLAQKSNVLSTPGMH KNFVTFIGLLLAFNCFTIHDIITYIIKPMFKVYLLHPQQSSQANQGTLSLQFVSLLLRHILVDKYIRGEVNDDGVNIVYP PFVSHYLLAKSKELSFDVVLNLLKELLKLSKDTLRSSRGTTWGGKTGMSILVESFPSGSQGNEAALIKLRETMELIAEQD WVREQCSKQDSKQLLHVEKLGDASLSPAQAQYLLHLLIPYCPEDTVKRINESSGSLPPFMTHPEQTVDRILKNLDQWT-- ---------------------------------------------------------------------------LHNAL LHLN---------------------------------------------------------------------------- ------------------------------------------LNINSSLHLHSIDHLSQSVIQVFEDSCTEEWTEDSSS- ---------------------------------------------------------QVDGAYCPSIWLVTPLVSELPKS VLGKILKSAGN--------------------------------------------------------------------- -------------VLGKGQWWNLDRQQERRRSTRASITPTTPNPKTGLQWQQPFLELVLACMNSNHSNHEELLGPLQKQL TTFLTAFEKDSFPADEQNKSMLYTALKLRLGLVGSMLPSVCSVCESNVLDWVSLLIPLICSGAVDRQPDNSELFTNCLDM LSALLQALSPDFHMCVFSGGEEGKKSYIMCIKKMKSDLASSKSTCKQEIQQLFP--------------LPQKLYEVTVVK PPSAFSQQFRIPEKVQG--------------------------------------------------------------- -------------------------------------------------------------------------------- ----LRVQEVKEISPWEIIEGIKNSGPFQLSWFGATRIKRKPLKYLEQEKQIQHHTHQHFLSNSGHLLGGSGPSTSRHSV FLPDSNDSTNGAIGGG----------------------------GGGGGVSSDSGDNAIPPGAASTAGGTRASVGG---- -----------------------------------------------------------------------------TGE GSGLDNKAEILLQINKMNREQQPSLTTQPGP-----------------------------LPPTFHTTGQVGVSNTPHQL TQQQPMQRQIPHGMMQQHSAAQMMRPPPHFLQRQLEYMTPEQRNHFMSLPNEE--------------------------- --------------KRVYLSNLQRTFRERRMLEQQQQQQQQQQLMFRHPMHPRPMQVAPPMQMTQVLQQRMMPRYGPQHM GPPQMHHSGGYMMPGHHPAMFRQPPPGPMYTMHRPPMHHNLPPHHQ---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Homo_sapiens_FAM110C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MRALAALSAP---PNERLLPRDPAATRDPD-AARPARR-------- -----------------------------------------------------------------------------SAV ERL----------------------------------------------------------------------------- -------------------------------------------AADRAKYVRGRPGTGRGVAS----------------- ------------------------------------------------------------------EGSGPGAIKCPGND P------------------------------------------------------------------------------- ----------------------GPPARAPAPVARRAIARKPLRP------------------------------------ -----------------DSLIIYRQK--CEFVRGS--------------------------------------------- -----------------------------GADGPRAS----------------------------------LVKKLFQGP GKDKAPVP----RT-------------------GDEGKAG---------------------------------------- -------------------------------------------------------------------------------- --------NPETVPTTPGPAADPAIP----ETPAPAAR--S-----AAPSSVPAA---------------PPGPEP-RVV R----------------------------------------------------------RRGLQRSQSDLSSRYS----- -------------------------------------------------------------------------------- --AALAESDTFFQYCGLDPEVVEALG-----------------------------------RENFTAGSDC-----VTLK VRSVS--VATSGSGFSRHSGGD--DEGLQE---------EELIEQVP--------------------------------- ----------------STTSVIERNARIIKWLY-TCKKAKETPSQEQSRTRGSKPSR----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Gorilla_gorilla_FAM110C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------S--------------------------------------------- -----------------------------GADGPRAS----------------------------------LVKKLFQGP GKDKAPVP----RT-------------------EDEGKAG---------------------------------------- -------------------------------------------------------------------------------- --------NPETVPTTPGPAADPATP----ETPAPAAR--S-----AAPSSVPAA---------------PPGPEP-RVV R----------------------------------------------------------RRGLQRSQSDLSSRYS----- -------------------------------------------------------------------------------- --AALAESDTFFQYCGLDPEVVEALG-----------------------------------RENFTAGSDC-----VTLK VRSVS--VATSGSGFSRHSGGD--DDGLQE---------EELIEQVP--------------------------------- ----------------STTSVIERNARIIKWLY-TCKKAKETPSQEQSRTRGSKPSR----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Macaca_mulatta_FAM110C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------L-AAQPEGE-------- -----------------------------------------------------------------------------SAV ERL----------------------------------------------------------------------------- -------------------------------------------AADRAKYVRGRPGTGRGVAS----------------- ------------------------------------------------------------------EGSGPGAIKCPGND -------------------------------------------------------------------------------- ----------------------------------RAIARKPLRP------------------------------------ -----------------DSLIIYRQK--CEFMRGA--------------------------------------------- -----------------------------GADGPRAS----------------------------------LVKKLFQGP GKDKVPVP----RT-------------------GDEGKTG---------------------------------------- -------------------------------------------------------------------------------- --------NPETVPTKPGAAADLAPP----ETPAPAAR--S-----AAPSSVPAA---------------PPGPEP-RVL R----------------------------------------------------------RRGLQRSQSDLSSRYS----- -------------------------------------------------------------------------------- --AALAESDTFFQYCGLDPEVVEALG-----------------------------------RENFTAGSDR-----VTLK VRSVS--VATSGSGFSRHSG-D--DDGLQE---------EELIEQVP--------------------------------- ----------------STTSVIERNARIIKWLY-TCKKAKETPSQEQSRTR----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Mus_musculus_FAM110C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MRALPTLDSL---ARMRPPLGDPRAAEDTL-TPRPANK-------- -----------------------------------------------------------------------------SAV ERL----------------------------------------------------------------------------- -------------------------------------------AADRAKYVRSTLGSSRGPVS----------------- ------------------------------------------------------------------EHRVPEAPGVQHRN P------------------------------------------------------------------------------- ----------------------IPSALAPAPVARRAIARKPLRP------------------------------------ -----------------DSLVIYRQK--CEFVRGS--------------------------------------------- -----------------------------DADCSRVG----------------------------------LMKKFFQGS GKDKMAVAPETTRV-------------------ADEDKTTKETEATWTKSS----------------------------- -----QAAAARPASMLPPPTPVVAVKSPAEKTRVANEDKTTKETEATWTKSSQAAAARPASMLPPPTPVVAVKSPAEKTR VANEDKTTKETEATWTKSSQAAATRPASMLPPPTPVVAVKSPALPFEVAPRVPVG---------------CSGVQL-RVS R----------------------------------------------------------SKGLQRSQSDLSSRYS----- -------------------------------------------------------------------------------- --IAKAESDTFFKYCGLDPDVVEALG-----------------------------------RENFSAGSDC-----VTLK VRSVS--MAASDSSFSRHSE-----DGLQE---------EELLEQVP--------------------------------- ----------------STTSVVERNARIIKWLF-TCKKAKETPSQKLQGPA----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Rattus_norvegicus_FAM110C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MRALPTLDSL---ARTRPSLGDSRAAEGTL-TRQPANK-------- -----------------------------------------------------------------------------SAV ERL----------------------------------------------------------------------------- -------------------------------------------AADRAKYVRSTLGSSRGPVS----------------- ------------------------------------------------------------------ENRVPEAPGVQHRN P------------------------------------------------------------------------------- ----------------------IPSTLAPAPVARRAVARKPLRP------------------------------------ -----------------DSLVIYRQK--CEFVRGS--------------------------------------------- -----------------------------DADSSRVG----------------------------------LMKKFFQGS GKDKMSVTPETTRV-------------------ADEYKT----------------------------------------- -------------------------------------------------------------------------------- --------KETEATWTKASQAAAAKPASMLPPPAPVVAMESPALPFEVAPRVPVR---------------RSGVEL-RAS R----------------------------------------------------------SKGLQRSQSDLSSRYS----- -------------------------------------------------------------------------------- --TARAESDTFFQYCGLDPEVVESLG-----------------------------------RENFSAASDC-----VTPK MRSVS--MATSDSSFSRHSE-----DGLQE---------EELLEQVP--------------------------------- ----------------STTSVVERNARIIKWLF-TCKKAKETPSQKLQEPA----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Canis_familiaris_FAM110C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MRALPGLDAP---QRQRPPAQQPEGPRGRD-AAVPARR-------- -----------------------------------------------------------------------------SAA ERL----------------------------------------------------------------------------- -------------------------------------------AADRAKYLRGPRGAGPAPEG----------------- ------------------------------------------------------------------SSAGPSAGAAGAPG P------------------------------------------------------------------------------- ----------------------PAPAPAPGAVARRTVARRPLRP------------------------------------ -----------------DSLVIYRQK--CDFVRGQ--------------------------------------------- -----------------------------GADGPRAG----------------------------------LVRKLFPGP GRDRAAACPGTARG-------------------DDELRAR---------------------------------------- -------------------------------------------------------------------------------- --------REGAVVSRPGSVGAPAAPGTPRGAPPAPPAPPA-----PPASSAPPA---------------PPGTPR-RAP AAPPAAPGTPRG---------APAAPPAPPAPPTPPASCAAPRTPASSAPPGPQPRGSRRGGLRRSQSDLSSRYS----- -------------------------------------------------------------------------------- --ASLAEFDTFFQFCGLDPEVLDALG-----------------------------------RENFSAGSDR-----VTPQ VRSVS--VATSDSGFSRRSGG---QEGLQE---------EELTEQVP--------------------------------- ----------------STTSVVERNARIIKWLY-TCKRAKETPGQGLQGPA----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Felis_catus_FAM110C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------PAGGEG-RAP -------------------------------------------------------------ELQRSQSDLSSRCS----- -------------------------------------------------------------------------------- --ASLAEFDTFFQFCGLEPEVVEALG-----------------------------------RENFSAGSDR-----VTLK VRSVS--VATSDSGFSRHSGG---EEGLQE---------EELTEQVP--------------------------------- ----------------STTSVVDRNARIIKWLY-TCKKARETPGQGLQ-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------- >Xenopus_tropicalis_FAM110C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------MPTDIMHAVRMHPIAELQHPSPAVPLRLLTRGPDYLRRQMEALGSPRANL------ -----------------------------------------------------------------------------SAV ERL----------------------------------------------------------------------------- -------------------------------------------AADKAKYVKTPQQQQQGVCVG--------------GS ----------------------------------------------------SSAGGSRGDPRGSSASDSSSGSSRGSQQ E------------------------------------------------------------------------------- ----------------------GTRGQQGTAPVRRGSSKRSNRP------------------------------------ -----------------DSLVIYRLK--SRGEGQQ--------------------------------------------- ------------------------------AEPARVG----------------------------------LVRRLFL-- -KEKPPGS------------------------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------AIPVPPQEHST-----PCPSERLSP------------