>Homo_sapiens_E2F1 -------------------------------------------------------------------------------- --------------------MALAGAPAGGPCAPALEALLGAG--ALRLLDSSQ------------------------IV IISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQ----APRPTPSAPRPALGR--------PPVKRRLDLETD----- HQYLAESS----GPARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSHSADGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHTTVGVGGRLEG---------------LTQD LRQLQESEQ------QLDHLMNI--CTTQ---LRLLSEDTDSQR------------------------------------ --------------------------------LAYVTC-----QDLRSIADPAE-QMVMVIKAPPETQLQAVDS------ ---------------SENFQISLKSKQG-PIDVFLCPEETVGG------------------------------------- --------------ISPGKTPSQEVTS-EEENRATDS------------------------------------------- -----------------------ATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSR-----------------MGSLRA PVDEDRLSPLVAA------------------------------------------------------------------- ------------------------DSLLEHVREDFSGLLPEE------------------FISLSPPHEA-LDYHFGLEE GEGIRDLF--DCDFGDLTPLDF------ >Gorilla_gorilla_E2F1 -------------------------------------------------------------------------------- --------------------MALAGAPAGGPCAPALEALLGAG--ALRLLDSSQ------------------------IV IISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQ----APRPTASAPRPALGR--------PPVKRRLDLETD----- HQYLAESS----GPARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSHSADGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHTTVGVGGRLEG---------------LTQD LRQLQESEQ------QLDHLMNI--CTTQ---LRLLSEDTDSQR------------------------------------ --------------------------------LAYVTC-----QDLRSIADPAE-QMVMVIKAPPETQLQAVDS------ ---------------SETFQISLKSKQG-PIDVFLCPEETVGG------------------------------------- --------------ISPGKTPSQEATS-EEENRATDS------------------------------------------- -----------------------ATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSR-----------------MGSLRA PVDEDRLSPLVAA------------------------------------------------------------------- ------------------------DSLLEHVREDFSGLLPEE------------------FISLSPPHEA-LDYHFGLEE GEGIRDLF--DCDFGDLTPLDF------ >Macaca_mulatta_E2F1 -------------------------------------------------------------------------------- --------------------MALAGAPAGGPCAPALEALLGAG--ALRLLDSSQ------------------------IV IISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQ----APRPTPSAPRPALGR--------PPVKRRLDLETD----- HQYLAESS----GPARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHTTVGVSGRLEG---------------LTED LRQLQESEQ------QLDHLMNI--CTTQ---LRLLSEDTDSQR------------------------------------ --------------------------------YPWIGR-----RDLRSIADPAE-QMVMVIKAPPETQLQAVDS------ ---------------SETFQISLKSKQG-PIDVFLCPEETVGG------------------------------------- --------------ISPGKTPSQEATS-EEENRATDS------------------------------------------- -----------------------ATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSR-----------------MGSLRA PVDEDRLSPLVAA------------------------------------------------------------------- ------------------------DSLLEHVREDFSGLLPEE------------------FISLSPPHEA-LDYHFGLEE GEGIRDLF--DCDFGDLTPLDF------ >Mus_musculus_E2F1 -------------------------------------------------------------------------------- ----------------------MAVAPAGGQHAPALEALLGAG--ALRLLDSSQ------------------------IV IISTAPDVGAPQLP---AAPPTGPRDSDVLLFATPQ----APRPAPSAPRPALGR--------PPVKRRLDLETD----- HQYLAGSS----GPFRG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHTMVGIGKRLEG---------------LTQD LQQLQESEQ------QLDHLMHI--CTTQ---LQLLSEDSDTQR------------------------------------ --------------------------------LAYVTC-----QDLRSIADPAE-QMVIVIKAPPETQLQAVDS------ ---------------SETFQISLKSKQG-PIDVFLCPEESADG------------------------------------- --------------ISPGKTSCQETSS--GEDRTADS------------------------------------------- -----------------------GPAGPPP-SPPSTSPALDPSQSLLGLEQEAVLPR-----------------MGHLRV PMEEDQLSPLVAA------------------------------------------------------------------- ------------------------DSLLEHVKEDFSGLLPGE------------------FISLSPPHEA-LDYHFGLEE GEGIRDLF--DCDFGDLTPLDF------ >Rattus_norvegicus_E2F1 -------------------------------------------------------------------------------- ----------------------MAVAPAGGQHAPALEALLGAG--ALRLLDSSQ------------------------IV IISTAPDVGAPQVPTGPAAPPAGPRDPDVLLFATPQ----APRPAPSAPRPALGR--------PPVKRRLDLETD----- HQYLAGSS----GPFRG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSHSADGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SRTMVGIGQRLEG---------------LTQD LQQLQESEQ------QLDHLMHI--CTTQ---LQLLSEDSDIQR------------------------------------ --------------------------------LAYVTC-----QDLRSIADPAE-QMVIVIKAPPETQLQAVDS------ ---------------AETFQISLKSKQG-PIDVFLCPEESAEG------------------------------------- --------------ISPGRTSYQETS---GEDRNADS------------------------------------------- -----------------------GTAGPPP-SPPSTSPTLDPSQSLLGLEQEAVLPR-----------------IGNLRA PMEEDRLSPLVAA------------------------------------------------------------------- ------------------------DSLLEHVKEDFSGLLPGE------------------FISLSPPHEA-VDYHFGLEE GEGIRDLF--DCDFGDLTPLDF------ >Felis_catus_E2F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------L--------PQVKRRLDLETD----- HQYLAESS----GPARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHAAVGIGGRLEG---------------LTQD LRQLQESER------QLDHLIHI--CTAQ---LRLLSEDSDSQRS----------------------------------- -------------------------------TLAYVTC-----QDLRSIADPAE-QMVMVIKAPPETQLQAIDS------ ---------------SETFQISLKSKQG-PIDVFLCPEESAGG------------------------------------- --------------ISPGKTSSQGTAS-GEEDRAVDP------------------------------------------- -----------------------ATTVPPP-SSPSSSPAADPSQSLLSLEQEPLLSR-----------------MGGLRA PVDEDRLSPLVAA------------------------------------------------------------------- ------------------------DSLLEHVREDFSGLLPEE------------------FISLSPPHEA-LDYHFGLEE GEGIKDLF--DCDFGDLTPLDF------ >Equus_caballus_E2F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------AAPPRSAA--------PPVKRRLDLETD----- HQYLAESS----GPTRG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHAAVGIGGRLEG---------------LTQD LRQLQESER------QLDHLIHI--CTTQ---LRLLSEDTDSQRY----------------------------------- -------------------------------PCTAWRA-----ADLRSIADPAE-QMVMVIKAPPETQLQAVDS------ ---------------SETFQISLKSKQG-PIDVFLCPEESAGG------------------------------------- --------------ISPGKTLSQGTAS-GEEDRAANP------------------------------------------- -----------------------ATTVPPP-SSPSSSPATDPSQSLLSLEQEPLLSR-----------------MGGLRA PVDEDRLSPLVAA------------------------------------------------------------------- ------------------------DSLLEHVREDFSSLLPEE------------------FISLSPPHEA-LDYHFGLEE GEGIRDLF--DCDFGDLTPLDF------ >Myotis_lucifugus_E2F1 -------------------------------------------------------------------------------- -----------------------ATGVCGGVGGQALRACLGRAR--GGLLDSWQ------------------------IV IISIAQDTSAP-LPPAPAVRAASPRDPDLLLFATPQ----APRPTP-SPRPALGR--------PPVKRRLDLETD----- HQYLAESS----GLARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------NHATVGIGGQLEG---------------LTKD LQQLQENER------QLDHLIHV--CTTQ---LQLLSEDADSQRS----------------------------------- -------------------------------TLAYVTC-----QDLRSIADPAE-QMVMVIKAPPETQLQAMDS------ ---------------SEAFQISLKSKQG-PIDVFLCPEESAGG------------------------------------- --------------ISPRKTPSQGATS-GEEDRAADP------------------------------------------- -----------------------TPTVPPS-SSLPSTPDVDPSQPLLSLEQEPLLSR-----------------MGGLRA AMDEDHLSPLVAA------------------------------------------------------------------- ------------------------DSLLEHVREDFSSLLPEE------------------FISLSPPHGA-LDYHFGLEE GEGIRDLF--DCDFGDLTPLDF------ >Erinaceus_europaeus_E2F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------VKRRLDLETD----- HQYLAESS----GPPRG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSHSSDGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLITKKSKNHIQWLG---------------------NHAAVGIGGRLEE---------------LTQD LQQLQESER------QLDHLIHI--CTTQ---LQLLSEDSDSQR------------------------------------ -----------------------------------YPG-----LDLRSIADPAE-QTVMVIKAPPETQLQAVDS------ ---------------AETFQISLKSKQG-PIDVFLCPEETVGG------------------------------------- --------------ASPGKTPSQGTAS-GEEDRTADA------------------------------------------- -----------------------ATTVPQP-----PSPAGDPSPSLLSLEQEPLVPR-----------------MGCLRA PVDEDRLSPLVAA------------------------------------------------------------------- ------------------------DSLLEHVREDFSG-LPEE------------------FISLSPPLEA-LDYHFGLEE GEGIKDLF--DCDFGDLTPLDF------ >Gallus_gallus_E2F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------PQVKRKLNLETD----- HQYIAESL----PAARG-----RARIPGRGAKSPGEKSRYETSLNLT-TKRFLELLSQSPDGVVDLNWAAEVLKVQ-KRR IYDITNVLEG-IQLITKKSKNNIQWLG---------------------SQVAAGASSRQRL---------------LEKE LRDLQAAER------QLDDLIQT--CTVQ---LRLLTEDPSNQSF----------------------------------- ---------------------------------AYVTC-----QDLRSIVDPSE-QMVMVIKAPPETQLQVSDP------ ---------------GEAFQVSVRSTQG-PIDVFLCPEDSSGV------------------------------------- --------------CSPVKSPFKAPAEELSPGSSQQ-------------------------------------------- ------------------------------RASPLLHSAQDVNM--LLPEA--LLPG-T---------------ALPTKC PTEDVSLSPLASM------------------------------------------------------------------- ------------------------DTLLEHGKDDFPGFLADE------------------FIALSPP-QP-QDYHFGLEE GEGISELF--DCDFGDFTHLDF------ >Anolis_carolinensis_E2F1 -------------------------------------------------------------------------------- -----------------------------------FQELQFIG-----WKILLF------------------------DF KVAISRN----------------------------------------WLKSTHPL--------ERVKRKLNLETD----- HQYIAESF----QGNRG-----RARNAVKGVKSPGEKSRYETSLNLT-TKRFLELLSQSPDGVVDLNWAADVLKVQ-KRR IYDITNVLEG-IQLITKKSKNHIQWLG---------------------SRSTVGGPSNCHG---------------LMKE LQDLQDAEQ------QLDTLIQM--CTTQ---FKLLTEDLENKRK----------------------------------- ---------------------------------AYVTC-----QDLRSVVDPSE-QLVMVIKAPPETQMQVSDP------ ---------------AEAFQIAVKSTQG-PIDVFLCPEESSEV------------------------------------- --------------CSPTKSPQKVAVGQRTPESSQ--------------------------------------------- ------------------------------AAAVVTTAATPVLLHPSQAEP--LLSGEN---------------TLPLKC PGDDVSLSPLASV------------------------------------------------------------------- ------------------------DTLLQQGKDDFSSFLPAE------------------FIALSPP-QT-QDYHFGLEE GEGISELF--DCDFGDFTSLDF------ >Xenopus_tropicalis_E2F1 -------------------------------------------------------------------------------- -------------------------------------ALWEAG----TFQVAEQ------------------------QI VIISTPDVPAEAAGN------PGLSEAELMLFTTPQ----GPSTSYTAQRPDLGR--------PPVKRKLDLETV----- SRYNQEAL----QTPRG-----KGKRPLKAVKSPGERSRYDTSLHLT-TKRFLELLSQSSDGVVDLNWAAQVLNVQ-KRR IYDITNVLEG-IHLITKKSKNHIQWLG---------------------YTSYAEYNSRYQS---------------TLKD CQKLEDQEK------QLDKLIHM--ANTQ---LKLFKEEILDTQQCT--------------------------------- --------------------------------FGYVTC-----QDLRSIADPSE-RMLMVIRYPPDTDMCVSDP------ ---------------AEAFQMSLKSTQA-PIDVFLCPDDSSGV------------------------------------- --------------CSPVTSPTKTSQAEPSSINQAEP------------------------------------------- -----------------------LPSVQPKEESPASIPMLDIGLGLLSDMQEPFLPP-------------------ENEI PLDSTLNCLPLSP------------------------------------------------------------------- ------------------------SNLLLDYRDAMPDFLPND------------------FISLSPA-SS-QEYSFGLQT CEGAAELFNFDCDFSGLTALDL------ >Danio_rerio_E2F1_a -------------------------------------------------------------------------------- ------------------MSEGFISGQTSEDLLADFESLLNNG--SIDLSEDHQ------------------------IV IISTPG-----TATTS-------TATGDILLFATPHHTSTGTTSLPDHRRPILGR--------PPVKRKLDLDSD----- HQYICTSRTASNGPTPP-----ATPAPPRVPKLAVEKSRYDTSLNLT-TKRFLDLLAQSPDGVVDLNWASQVLDVQ-KRR IYDITNVLEG-IHLISKKSKNNIQWLG---------------------NRIDGASLARFQE---------------LQKE VSELTEAEE------KLDELINK--CSLQ---LRLLTEDTHNKKY----------------------------------- -------------------------------PLRYVRC-----QDLRNTVDPPD-QIIMVIRAPAETAMQVSEP------ ---------------SEGYQISLKSSKG-PIDVFLCPEDSSGV------------------------------------- --------------CSPVTDCSPAKSSNQSPAKSDPA------------------------------------------- -----------------------SQEVTSTPTTLPSSSPLPLHTDSESFLDSDPFSGIC--------------------- AMPDFDLSPLDSD------------------------------------------------------------------- ------------------------FLLERSGAADGLGLPLDS------------------FICLSPP-HS-QDYHFGLED HEGVSELF--DCDFSDLVPLEF------ >Takifugu_rubripes_E2F1_a -------------------------------------------------------------------------------- ------------------------------------ETLLNSG--SIDLSQDHQ------------------------IV IITSPSNEGLHPGSAP-------TSTGEILLFATPQ--GPADVGLHDKRRPALGR--------PPVKRKLDLDSD----- HQYVSTTR-PCIGQAP------STPAPPRVPRNTTEKSRYDTSLNLT-TKRFLNLLSQSADGVVDLNWASQVLDVQ-KRR IYDITNVLEG-IHLISKKSKNNIQWLG---------------------NRVDTALVSRHKE---------------LQKE VCDLTEAEE------QLDQLISK--CSLQ---LRLLTEDPQNNT------------------------------------ --------------------------------WGYVRC-----QDLKRSFDSPD-QLLMVIRAPPETQMQVSEP------ ---------------SKGFEMSLKSTQG-PIDVFLCPEDSSGA------------------------------------- --------------CSPVSGSSPTKTN-TEPSLVPPV------------------------------------------- -----------------------AQPTDQSNASGSTATLQLHHWPVSSAGPSLHAPVP---------------------- DMPDFDLSPLSAA------------------------------------------------------------------- ------------------------DFLN----GEGFSLPLDG------------------FINLSPP-HS-HDYHFGLED HEGISELF--DCDFGDLTHVLG------ >Tetraodon_nigroviridis_E2F1_a -------------------------------------------------------------------------------- ----------------------LITGQTSEDILADFETLLNSG--SIDLGEDHQ------------------------IV IITSPGNEGLHPGSAP-------TSTGEILLFATPQ--GPADVGLQDKRRPALGR--------PPVKRKLDLDSD----- HQYVSTTR-PCIGQAPP-----STPAPPRVPRNLTEKSRYDTSLNLT-TKRFLNLLSQSADGVVDLNWASQVLDVQ-KRR IYDITNVLEG-IHLISKKSKNHIQWLG---------------------NRVDTALVSRHKE---------------LQKE VCDLAEAEE------QLDQLVSK--CSLQ---LRLLTEDPQNNT------------------------------------ --------------------------------WGYVRC-----QDLKKSVDSPD-QLLMVIRAPPETQMQVSEP------ ---------------SKGFEMSLKSTQG-PIDVFLCPEDSSGA------------------------------------- --------------CSPVTGSSPAKA--TGPSLVP--------------------------------------------- -----------------------EQTTDQSKTRGSTALLEESSSSPASTSSTVTAASQQDSSSLPMG------NDSGYVS DMPNFDLSPLSAA------------------------------------------------------------------- ------------------------DFLN----GEGFPLPLDG------------------FINLSPP-HS-HDYHFGLED HEGISELF--DCDFGDLTHVLE------ >Gasterosteus_aculeatus_E2F1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------EILLFATPQ--GSVDVGVQDKRRPALGR--------PPVKRKLDLDSD----- HQYVSTTR-PSIGQAPP-----S------IPRTATEKSRYDTSLNLT-TKRFLNLLSQSADGVVDLNWASQVLDVQ-KRR IYDITNVLEG-IQLISKKSKNNIQWLG---------------------NRVDAALVSRQKD---------------LHGE VCDLKDAEE------QLDQLISK--CNLQ---LRLLTEDTQNNT------------------------------------ --------------------------------LGYVRC-----QDLKKSFDSPD-QLVMVIRAPPETQMQVSEP------ ---------------SKSYQVSLKSTRG-PIDVFLCPEESSGV------------------------------------- --------------CSPVTGGSPSKP---DPLLVPPP------------------------------------------- -----------------------ARPTDQSQARNSTAAQDETLLSPESLLGGDPFSGLG--------------------- EMPDFNLSPISSS------------------------------------------------------------------- ------------------------DFLN----ADGIPLPLDG------------------FINLSPP-HS-HDYHFGLED HEGISELF--NCDFDDLSQVLG------ >Oryzias_latipes_E2F1_a -------------------------------------------------------------------------------- ----------------------CCRSPLGGRQCHDFETLLNSG--SIDLSQDHQ------------------------IV IITSPSNEGLHPLAAP-------SSTGEILLFATPQ--SHADAGGQDRRRPALGR--------PPVKRKLDLDSD----- HQYVSTTR-SSASQAPP-----STPAPPRVPRSTAEKSRYDTSLNLT-TKRFLNLLSQSADGVVDLNWASQVLDVQ-KRR IYDITNVLEG-IQLISKKSKNHIQWLG---------------------NRIDASMVSRHKE---------------LQRE ACDLTEAEE------QLDELIAK--CNLQ---LRLLTEDPQNKK------------------------------------ --------------------------------LGYVRC-----QDLRQSFDSPD-QLVMVIRAPPETQMQVSEP------ ---------------SEGYQVSLKSTRG-QIDVFLCPEDSSGV------------------------------------- --------------CSPVTGTSPSKT---G--ADPSL------------------------------------------- -----------------------ASPLLPHPAE---PPPQFPFPPTESLLGGDPFSSLG--------------------- DMADFDLSPLSSS------------------------------------------------------------------- ------------------------DFLN----GEGLPLALDN------------------FINLSPP-QS-HDYHFGLED HEGISELF--DCDFDELSHVLG------ >Homo_sapiens_E2F2 ------------------------------------------------------------------------------ML QGPRALASAAG--------------QTPKVVPAMSPTELWPSGLSSPQLCPAT--------------------------- -------ATYYTPLYPQTAPPAAAP--GTCLDATPHGPEGQVVRCLPAGR-------------LPAKRKLDLEGI----- GRPVVPEFPTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KQQ--------QLGQE LKELMNTEQ------ALDQLIQS--CSLS---FKHLTEDKANKR------------------------------------ --------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------ --------------TEDNLQIYLKSTQG-PIEVYLCPEEVQEP------------------------------------- --------------DSPSEEPLPSTSTLCPSP------------------------------------------------ -----------------------DSAQPSSSTDPSIMEPTAS-----SVPAPAPTPQQ--------------APPPP--S LVPLEATDSLLELP------------------------------------------------------------------ ------------------------HPLLQQTEDQFLSPTLA--------------CS-SPLISFSPSLDQ-DDYLWGLEA GEGISDLF-DSYDLGDLLIN-------- >Pongo_abelii_E2F2 ------------------------------------------------------------------------------ML QGPRALASAAG--------------QTPKVVPAMSPTELWPSGLSSPQLCPAT--------------------------- -------ATYYTPLYPQTAPPAAAP--GTCLDATPHRPEGQVVRCLPAGR-------------LPAKRKLDLEGI----- GRPAVPEFPTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KQQ--------QLGQE LKELMNTEQ------ALDQLIQS--CSLS---FKHLTEDKANKR------------------------------------ --------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------ --------------TEDNLQIYLKSTQG-PIEVYLCPPAVLDK------------------------------------- --------------DSPSEEPLPSTSTICPSP------------------------------------------------ -----------------------DSAQPSSSTDPSIMEPTAS-----SLPAPAPTPQQ--------------APPPP--S LVPLEATDSMLELP------------------------------------------------------------------ ------------------------HPLLQQTEDQFLSPTLA--------------CS-SPLISFSPSLDQ-DDYLWGLEA GEGISDLF-DSYDLGDLLIN-------- >Macaca_mulatta_E2F2 ------------------------------------------------------------------------------ML QGPRALVSAAG--------------QPPKVVPAMSPTELWPSGLSSPQLCPAT--------------------------- -------TTYYTPLYPQTAPPAVAP--GTCLDATPHGPEGQVVRCLPAGR-------------LPAKRKLDLEGI----- GRPAVPEFPTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KQQ--------QLGQE LKELMNIEE------ALDQLIQS--CSLS---FKHLTEDKANKR------------------------------------ --------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------ --------------TEDNLQIYLKSTQG-PIEVYLCPEEVQEP------------------------------------- --------------DSPSEEPLPSTSTLCPSP------------------------------------------------ -----------------------DSAQPSSSTDPSIMEPTAS-----SVPAPAPTPQQ--------------APPPP--S LVPLEATDSMLELP------------------------------------------------------------------ ------------------------HPLLQQTEDQFLSPTLA--------------CS-SPLISFSPSLDQ-DDYLWGLEA GEGISDLF-DSYDLGDLLIN-------- >Mus_musculus_E2F2 ------------------------------------------------------------------------------ML RAPRTLAPATA--------------QPTKSLPALNPTELWPSGLSSPQLCPATT-------------------------- ------ATTYYTSLYTQTVPSSVAL--GTCLDATPHGPEGQIVRCAPAGR-------------LPAKRKLDLEGI----- GRPTVPEFRTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR IYDITNVLEG-IQLIRKKSKNNIQW-----------------------VGRELFEDPTRPS---RQQ--------QLGQE LKELMNAEQ------TLDQLIQS--CSLS---FKHLTEDNANKK------------------------------------ --------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------ --------------AEENLQIYLKSTQG-PIEVYLCPEEGQEP------------------------------------- --------------DSPAKEALPSTSALSPIP------------------------------------------------ -----------------------DCAQPGCSTDSGIAETIEP-SVLIPQPIPPPPPPP--------------LPPAP--S LVPLEATDNMLELS------------------------------------------------------------------ ------------------------HPLLQQTEDQFLSPILA--------------AN-SPLISFSPPLDQ-DEYLWGMDE GEGISDLF-DSYDLGDLLIN-------- >Rattus_norvegicus_E2F2 ------------------------------------------------------------------------------MG CGLVSPAGVSQ--------------AWRERGGAAGPQLLVLKTLGKDSLCLSKER------------------------- MTSSPFRGPWILELEPKRGGGVFVLF-PNVGTSLGCGTEPGSPLGLGGCRSHPDKGQLWGCDGHQAKRKLDLEGL----- GRPTVPEFRTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR IYDITNVLEG-IQLIRKKSKNNIQW-----------------------VGRGIFEDPTRPA---KEQ--------QLGQE LKELMNAEQ------TLDQLIQS--CTLS---FKHLTEDNANKK------------------------------------ --------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------ --------------AEENLQIYLKSTQG-PIEVYLCPEEGQEA------------------------------------- --------------DSPTKEALPSTSTLSPVP------------------------------------------------ -----------------------DCAQPGCSTDSGLAETIES-----SVLMPQPVPPPL-------------PPPPPAPS LVPLEATDNMLELS------------------------------------------------------------------ ------------------------HPLLQQTEDQFLSPILT--------------AS-SPLISFSPPLDQ-EEYLWGMDE GEGISDLF-DSYDLGDLLIN-------- >Canis_familiaris_E2F2 ------------------------------------------------------------------------------ML RGPRAPAAAAG--------------PPSKALPAMSPTEPWPPGLSSPQLCPAT--------------------------- -------ATYCTSLYPQTVPPPAAA--GTCLDATPHGPEGQAVRCVPAGR-------------LPAKRKLDLEGI----- GRPAIPEFRTPKGKCIRV-EGLPSP---RTPKSPGEKTRYDTSLGLL-TKKFIYLLSESKDGVLDLNWAAEVLDVQ-KRR IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KQQ--------QLGQE LKELMSMEQ------ALDQLIQS--CSLN---FKHLTEDKANKR------------------------------------ --------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------ --------------NEENLQIYLKSTQG-PIEVYLCPEEVQDP------------------------------------- --------------DSPAKERLPPASTLGPSP------------------------------------------------ -----------------------DSTQPSSSTDPGMTDPVAS-----SASHPPPAPPP--------------PPPPP--P LVPLEATDSMLELP------------------------------------------------------------------ ------------------------HPLLQQTEDQFLSPTLP--------------CS-SPLISFSPPLDQ-DDYLWGLDG GEGISDLF-DSYDLGDLLIN-------- >Felis_catus_E2F2 ------------------------------------------------------------------------------ML RGPRALAPAAG--------------PPSKGLPAMSPTELWPPGLSSPQLCPAT--------------------------- -------TTYYTSLYPQTVPPTAAP--GTCLDATPHGPEGQAVRCVPAGR-------------LPAKRKLDLEGI----- GKPAVPEFRTPKGKCIRL-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESKDGVLDLNWAAEVLDVQ-KRR IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KRQ--------QLGQE LKELMSTEQ------ALDQLIQT--CSLN---FKHLTEDKANKR------------------------------------ --------------------------------LAYVTY-----QDIRAVGSFKE-QTVIVVKAPPQTRLEVPDR------ --------------SEENLQIYLKSTQG-PIEVYLCPEEVQEP------------------------------------- --------------DSPTKDPFPSPSPLGPIP------------------------------------------------ -----------------------DSTQPSSSTDPGMTEPMASPGPALTPQQALQLPAP--------------PPPPL--P LVPLEATDSMLELP------------------------------------------------------------------ ------------------------HPLLQQTEDQFLSPTLP--------------CS-SPLISFSPPLDQ-DDYLWGLDG GEGISDLF-DSYDLGDLLIN-------- >Myotis_lucifugus_E2F2 ------------------------------------------------------------------------------ML RGPRAPAPAAA--------------LPLKGLPALSPTELWPPGLGSPQLCPVT--------------------------- -------TAYYTSLYPQTVPPATVP--GTCLDATPHGPEGQAVRCVPAGR-------------LPAKRKLDLEGI----- GRPAVLEFQTPKGKLIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESKDGVLDLNWAAEVLDVQ-KRR IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGALEDPTRPG---KQQ--------QLGQE LKELMSMEQ------ALDQLIQS--CSLN---FKHLTEDKANKK------------------------------------ --------------------------------LAYVTY-----QDIRAIGTFKE-QTVIAVKAPPQTRLEVPDR------ --------------NEENLQIYLKSTQG-PIEVYLCPEEMQEP------------------------------------- --------------DSPAKEPVPSTSTLSPTP------------------------------------------------ -----------------------DSAQPCSSTNPGILEPTASPDLSPAPSLTSQQALL--------------PPP----S LVPLEATDSMLELP------------------------------------------------------------------ ------------------------QPLLQQTEDQFLTD------------------S-SPLISFSPPLDQ-DDYLWGLDG GEGISDLF-DSYDFGDLLIN-------- >Monodelphis_domestica_E2F2 ------------------------------------------------------------------------------ML RIPKGVSPAPGGSAPAAPQKPPQPLQIKKALPVVS--PVWTPDVRSPQGGPVP--------------------------- -------ASHFTPLYPPMVAAVAPAAPGSCLDATPQGPEIRASR-ASAGR-------------LPAKRKLDLEGM----- GRQGLSEFRTPKGKCGGG-EGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLEVQ-KRR IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPAGPR---KQQ--------SLGQE LKDLSDTER------VLDQLIQS--CTSD---LKHLTEDETNQR------------------------------------ --------------------------------YPSWRRGPRMGGDIRAIGNFKD-QTVIAVKAPPETRLEVPDL------ --------------REENLQIYLKSTNG-PIEVYLCPEDNRE-------------------------------------- --------------AGGSSQE----------A------------------------------------------------ -----------------------PPSDPGP-------------------------------------------FPGRSSS PSS----------------------------------------------------------------------------- ------------------------------------------------------------------------SCSLDLIA PPGRCLAI-GAFFLSVWA---------- >Pelodiscus_sinensis_E2F2 ------------------------------------------------------------------------------ML RVPKGVSSA--------------PQQQKKIMPVMSSADLVTSSLSSPQMHSIP--------------------------- -------ASYFMQVYPQTVAAAPPPR-GSCLYATPHGPEIKAIRSASAGR-------------LPAKRKLDLEGT----- GQPGLPEFRTPKGKGRMV-TRIPSPRTTKAPKSPGEKTRYDTSLGLL-TKKFIHLLSESEDGVLDLNRAAEVLEVQ-KRR IYDITNVLEG-IQLIRKKSKNNIQW-----------------------MGTGIFEDTSVTV---KQQ--------SLRQE LAELAKTER------KVDELIQD--CTLQ---LKHLTEDETNQR------------------------------------ --------------------------------LAYVTY-----QDIRAIGNFQE-QTVIAVKAPPETKLEVPDF------ --------------SEENVQLHLKSTNG-PIEVYLCPEEILD-------------------------------------- --------------DSPAKESSFLTPSLQDSS------------------------------------------------ -----------------------DGTDPSPGKGKGGLWPGLA-----WSPLPSPVLWGL-------------TFPFVAAA APLMEVEDGLLDVP------------------------------------------------------------------ ------------------------HHLLQQTEDQLPYGD-----------------P-APFVSFSPPLDQ-DDYLWGLEG GEGVSDLF-EAYDLGDLLKN-------- >Takifugu_rubripes_E2F2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------AKRKLDLED------ -PLYMPEFRTPKGKCNIA-ARLTSP---RTPKSPGERTRYDTSLGLL-TKKFVGLIAESPDGVLDLNWATEVLEVQ-KRR IYDITNVLEG-VQLIRKKSKNHIQW-----------------------LVGDVFEGGTGGG---QKAC-------TLRKE IGDLEQAEK------CLDELILS--STGQ---LKQLTEHGDNQR------------------------------------ --------------------------------LGYVTY-----HDIRSIGSLQD-QTVIAVKAPADTKLEVPDTE----- --------------GE-SLQIYLKSKNG-PIEVYLCPEDGLED------------------------------------- --------------ASPVKSVSTPKKEFPPTVCTSH-------------------------------------------- -----------------------TTSTAPPSCSIKEEPVEFTIRIPAHIPAAAAASSS---------------------S ILDVEGLLG---LP------------------------------------------------------------------ ------------------------PSLLQITEDQLPSATFTPD------------PN-TPFVSFSPPLDH-DDYLWSLDD GEGVSDFF-DTYDLGDLLSN-------- >Tetraodon_nigroviridis_E2F2_a ------------------------------------------------------------------------------MM RMPKGVSAASGRPAAG----LSCSQTKMKLLSAGVKTEFFSAGLSSPLMNAVP--------------------------- -----------AGYFTQICNTTAAEQRANSLYSTPHGPEAKPIRASSGRM--------------PAKRKLDLED------ -PLYMPEFRTPKGKCNIA-ARLTSP---RTPKSPGERTRYDTSLGLL-TKKFVGLIAESPDGVLDLNWATEVLEVQ-KRR IYDITNVLEG-VQLIRKKSKNHIQW-----------------------LVGDVFEGGAGGG---QKAG-------ALRKE LGDLERAEK------CLDELILS--STAQ---LKQLTEYEDNQR------------------------------------ --------------------------------LGYVTY-----QDIRSIGSFQD-QTVIAVKAPADTKLEVPDTE----- --------------GQGSLQIYLKSKNG-PIEVYLCPEEALED------------------------------------- --------------ASPVKSASTPKKDILQTICPPAPA------------------------------------------ -----------------------TSSTAPPSCSIKEEPVESK----PSSAHVAAASSA---------------------S ILDVEGLLG---LP------------------------------------------------------------------ ------------------------PSLLQITEDQLPSASFAPD------------PN-TPFVSFSPPLDH-DDYLWSLDD GEGVSDFF-DSYDLGDLLSN-------- >Gasterosteus_aculeatus_E2F2_a ------------------------------------------------------------------------------MM RMPKGVSPAPGRQKIK----VVS--------TAGGKHEFFSTGLSSPPMSTVP--------------------------- -----------PGYFTQICNTAAGEQRANSLYSTPHGPEAKPIRSSCGRL--------------PAKRKLDLED------ -PLYLPEFRTPKGKCSIA-ARIPSP---RTPKSPGERTRYDTSLGLL-TKKFVGLIAESPDGVLDLNWATEVLEVQ-KRR IYDITNVLEG-VQLIRKKSKNNIQW-----------------------LVGDVFEGGASGG---EKAC-------ALRKE LGELERVER------SLDDLVQS--STAQ---LKQLTEYEDNKRYPLR-------------------------------- ------------------------------CTLGYVTY-----QDIRSIGTLRD-QTVIAVKAPADTKLEVPDTA----- --------------GQGSLQIYLKSKNG-PIEVYLCPEEGLED------------------------------------- --------------ASPGKSAATPIKEFSKPLDPPT-------------------------------------------- -----------------------ATAMAPPSYSAKEEPAEP------TLLLEAVDSLC---------------------P KELINGLLG---LP------------------------------------------------------------------ ------------------------PSLLQLTDDQLPCTSFAPD------------PN-APFVSFSPPLDH-DDYLWSLED SEGVSDFF-DTYDLGELLKS-------- >Hydra_magnipapillata_E2F2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MQPLQPIIFTTFKTPSKVFMA------------------NSQTKQIIRSAP------ -QPIAPATFKTKLNSPAL------EEKLAVQKSPACERRYETSLGIL-TKRFVSLLRNSVSGILDLNQAAELLDVQ-KRR IYDITNVLEG-IGVIEKNSKNNIKWVG---------------------AKHLENQNDNIADVENQEEAILATNLVDLHQD IEDLKLSEA------KLDELIQQ--CQNE---MKQCSGAKHYNK------------------------------------ --------------------------------HSYVTY-----QDIRGIKDFNN-KTVIAIKAPPETKLEVPDP------ ---------------NESIQIWLKSSNG-PIDVYLCPENKENV------------------------------------- --------------PPSNDRLDECAYSDSTSSVSEFSP------------------------------------------ ------------------------FNNENLCSPGNLSQSSGYFDECQFSSYDANTTLS---------------------- SMNCDALHINKLDS------------------------------------------------------------------ ------------------------EDFIAYNESCYQNELSIS-----------------PLISLEPNFKA-EDYLFSLDC NEGISDLF----DVDTFL---------- >Homo_sapiens_E2F3 ------------------------------------------------------------------------------MR KGIQPALEQYLVT-------------AGGGEGAAVVAAAAAASMDKRALLASPGF-AAAAAAAAAPGAYIQILTTNTSTT SCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALGRGGSG--GGGGPPAKRRLELGESG---- HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE VTELSQEEK------KLDELIQS--CTLD---LKLLTEDSENQR------------------------------------ --------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDS------ --------------IES-LQIHLASTQG-PIEVYLCPEE-TET------------------------------------- --------------HSPMKTNNQDHNGNIPKP--ASK------------------------------------------- ---------------------------DLASTNSG--------------HSDCSVS------------------------ ---MGNLSPLASP------------------------------------------------------------------- ------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE EEGISDLF-DAYDLEKLP-LVEDFMCS- >Macaca_mulatta_E2F3 ------------------------------------------------------------------------------MR KGIQPALEQYLVT-------------AGGGEGAAVVAAAAAASMDKRALLASPGF-AAAAAAAAAPGAYIQILTTNTSTT SCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALGRGGSG--GGGGPPAKRRLELGESG---- HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE VTELSQEEK------KLDELIQS--CTLD---LKLLTEDSENQRYP---------------------------------- --------------------------------LSYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDS------ --------------IES-LQIHLASTQG-PIEVYLCPEE-TET------------------------------------- --------------HSPMKTNNQDHNGNIPKP--TSK------------------------------------------- ---------------------------DLASTNSG--------------HSDCSIS------------------------ ---MGNLSPLASP------------------------------------------------------------------- ------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE EEGISDLF-DAYDLEKLP-LVEDFMCS- >Oryctolagus_cuniculus_E2F3 ------------------------------------------------------------------------------MR KGIQPALEQYLVT-------------AGGGEGAAVVAAAAAAAMDKRALLASPG----FAAAAAAPGAYIQILTTNTSTS SCSSSLQSGAVAAGPLLPSAPGAEPTAGSLLYTTPHGPSSRAGLLQQAPAPGRGGSG--GGGGPPAKRRLELGESG---- HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE VTELSQEEK------KLDELIQS--CTLD---LKLLTEDSENQR------------------------------------ --------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDS------ --------------IES-LQIHLASTQG-PIEVYLCSEE-TET------------------------------------- --------------HSPVKTNNQDHNGNIPKP--TSK------------------------------------------- ---------------------------DLASTNSG--------------HSDCSIS------------------------ ---MANLSPLASP------------------------------------------------------------------- ------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE DEGISDLF-DAYDLEKLP-LVEDFMCS- >Felis_catus_E2F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------LQAKRRLELGESG---- HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE VTELSQEEK------KLDELIQT--CTLD---LKLLTEDSENQR------------------------------------ --------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDP------ --------------IES-LQIHLASTQG-PIEVYLCPEE-TET------------------------------------- --------------HSPMKTNNQDHNGNIPKP--PSKEVVTEFPPSLPDPS----------------------------- ------------VMGTRH---------DLASTNSG--------------HSDCSIS------------------------ ---MANLSPLASP------------------------------------------------------------------- ------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE EEGISDLF-DAYDLEKLP-LV------- >Dasypus_novemcinctus_E2F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------PSFVLQAKRRLELGESG---- HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE VTELSQEEK------RLDELIQS--CTLD---LKLLTEDSENQR------------------------------------ --------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDP------ --------------LES-LQIHLSSTQG-PIEVYLCPEE-TET------------------------------------- --------------HSPMKTNNQDHNGNIPKP--TSKAQRSEFHFFLLQPP----------------------------- ------------NIAARIGVIIEIPISDLASTNSG--------------HSDCSVS------------------------ ---MANLSPLASP------------------------------------------------------------------- ------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE EEGISDLF-DAYDLEKLP-LV------- >Monodelphis_domestica_E2F3 ------------------------------------------------------------------------------MR KGIQPALEQFLVT-------------AGGGEGAAAAAAAAAASMDKRALLASPG------FPAAAPGTYIQILTTNTTTT SCSSSLQSGGAAAGPQHTNVPGVEQTAGSLLYSTPHGPSSRAGLLQQQPALGRGG-----GGGPPAKRRLELGESG---- HQFLSDGLKTPKGKGR---AAVRSPDSPK------KKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSDDGGMLA---QCQG--------LSKE VTELSQEEK------RLDELIQS--CTLD---LKLLTEDSENQK------------------------------------ --------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDP------ --------------LES-LQIHLSSNQG-PIEVYLCPEE-NET------------------------------------- --------------HSPVKSYNQDHNGNIPKP--SSK------------------------------------------- ---------------------------DVASTNSG--------------HADCSIS------------------------ ---MANLSPLASP------------------------------------------------------------------- ------------------------TNLLQQTEDQIPSNLEG------------------PFVNLLPPLIQ-EDYLLSLGE EEGISDLF-DAYDLEKLP-LVEDFMCS- >Taeniopygia_guttata_E2F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------AKRRLELGGSG---- HQYLAEGLKTPKGKGR---AATRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNRAAEVLKVQ-KRR IYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCSLSEDGGMLA---QRQG--------LTKE VTELTQEEK------KLDELIQS--CTLD---LKLLTEDSENQRYPFS-------------------------------- -----------------------------QNLQTYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDP------ --------------VES-ALIHLSSTQG-PIEVYLCPEE-NDA------------------------------------- --------------LSPMKTYSQDHNGNISKT--ISK------------------------------------------- ---------------------------EVASANSG--------------QGDCSVN------------------------ ---MATISPLASP------------------------------------------------------------------- ------------------------ANLLQQTEDQIPSNFEG------------------PFLNLLPPLLQ-EDYLLSLGD EEGISDLF-DAYDLEKLPSLMDEFIYS- >Xenopus_tropicalis_E2F3 ------------------------------------------------------------------------------MR KGTQGGHEKLLLP-------------GLQGTDKGSGLAGGFIAGGGGVVGAGGG-------------------------- ---GYVQIISSPGPPLHHHGLCIPEQAASFIYSTPHGPATRAGQLQP------------ALGRPPAKRRLELGDGS---- HQYLSDGLKTPKGKGR---AVTHCPDSPKTPKSPLEKTRYDTSLGLL-TKKFIQLLSQSSDGVVDLNRAAEVLKVQ-KRR IYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCTLPDDGGNLA---KSQE--------LSKE LSELAQEEN------KLDELIKN--CTLD---LKHLTENAENQRYP---------------------------------- --------------------------------FSYVTY-----QDIRKISGLKE-QTVIVIRAPPETRLEVPDP------ --------------VES-LQIHLSSSQG-AIEVYLCPEE-SES------------------------------------- --------------SSPVKQCNQDHNGNVSKPKPHSK------------------------------------------- ---------------------------DSLSPNME--------------NVNCSVE------------------------ ---G--ISPLTSP------------------------------------------------------------------- ------------------------TNLLQQTEDQISLNMDA------------------PFVNLLPPLMQ-EDYLLSLGD EEGISDLF-DAYELEKLP-SLDDFMCS- >Danio_rerio_E2F3_a ------------------------------------------------------------------------------MR KGGSSVPGQVMLT-------------GVVRAEQHG--VFTAVSDRRCA-------------------------------- ------VYSNATRIQINTPPS------TNNGCVPEASADSLYTTPLQGSTHGTGLRP--TLGRPPAKRRLELDITD---- HQY-SEPAKTLRSRKG-----ALKLKIPKAPKTPPEKTRYDTSLGFL-TKKFCQLLAQSSDGVLDLNKAAIVLNVQ-KRR LYDITNVLEG-VRLIKKKSKNNIQW-----------------------LGSSLPSDGGLPSPAMQSHS--------LARE MLALTQEER------RLDELIQT--CTRN---VQQMTEEIHSQK------------------------------------ --------------------------------YAYVTY-----QDIRRIKSLKD-QTVIAIKAPSETKLEVPDP------ --------------KES-LQVHLSSSKG-PIDVFLCTDG-GDS------------------------------------- --------------GSPLQNG-LDVNGNHPAFLKVS-------------------------------------------- -------------------------QEAASDGPADNVKMNG--------NSNASVNGF--------------------GP VSGNAPMSPLSSSL------------------------------------------------------------------ ------------------------SSILQQPEEAIP------------------------FVPLSPALLS-DEYMLGLGD EQGISDLF-DSCDLD---TLALDDLLRI >Takifugu_rubripes_E2F3_a ------------------------------------------------------------------------------MR RGISSASEKVILT-------------GVGGSSLDSNIILTTLSDRLNP-------------------------------- ------GQSNATFIQIITTPPPCNVTQT-NVCLSEPQINSIYTTPQQGAANGARQRP--ALGRPPAKRRLALDDSD---- HQHQPEPIRTP-RGKGPT-ANGTRIKTPKTPKSPPEKTRYDTSLGLL-TKKFVELLGQSSDGVLDLNLAAETLQVQ-KRR LYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCSLLEEEGSLS---QRQR--------LTDE VSALGEEEQ------RLEQLIQR--CSTD---MRHMSELSSNQK------------------------------------ --------------------------------YAYITY-----QDIKQLGNLRD-QTVIVVKAPTDTKLEVTDP------ --------------DES-LSIHLTSTQG-PIDVLLCPDDDSHP------------------------------------- --------------TSPVKNGGTDINGNSPFL------------------------------------------------ ---------------------------KVLQAPSPGAPP-----------AAAAVS------------------------ ---VTTLSPISSPY------------------------------------------------------------------ ------------------------TSLLQQTEDQIPTSL-G------------------PFLNLAPPLLEQDDYLLGLGD DQGISDLF-DACDFDKIRSLGLDDLLCS >Tetraodon_nigroviridis_E2F3_a ------------------------------------------------------------------------------MR RGISSAPEKVILT-------------GVGGSSLDSNIILTTLADRLNP-------------------------------- ------GQSNATFIQIITTPPPCNVTRT-NVCLSEPQINNIYTTPQQGAANGAGQRP--ALGRPPAKRRLALDDSD---- HQHQSEPIRTP-RGRGAT-ANGTRIKAPRTPKSPPEKTRYDTSLGLL-TKKFVELLGQSSDGVLDLNLAAETLQVQ-KRR LYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCSLLEEEGSLS---QRQS--------LTDE VSALGEEEQ------RLEQLIQT--CSKD---MRCMSELSSNQKFS---------------------------------- -------------------------------TYAYITY-----QDIKQLGNLKD-QTVIVVKAPTDTKLEVTDP------ --------------DES-LSIHLTSTKG-PIDVLLCPDDDNDP------------------------------------- --------------KSPVKNGGTDINGNSPYPG----------------------------------------------- ---------------------------SVAAAPSPGPPPPA--------AAAAAVS------------------------ ---ITTLSPISSPY------------------------------------------------------------------ ------------------------TSLLQQTEDQIPTSL-G------------------PFLNLGPPLLEQDDYLLGLGD DQGISDLF-DACDFDKIRSLGLDDLLCS >Gasterosteus_aculeatus_E2F3_a ------------------------------------------------------------------------------MR RGISSAPDKVILT-------------GVGG-SLDNNIILTALTDRLNA-------------------------------- ------GQSNATYIQIITTPPPCNITQTSNVCLSEPQINNIYTTPQQAGANGTGQRP--TLGRPPAKRRLALDDSD---- HQYQSEPVRTRGRVGTAV-ANGARPKTPRTPKSPPEKTRYDTSLGLL-TKKFVDLLAQSSDGVLDLNLAAETLQVQ-KRR LYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCSLLEVEGALS---QRQR--------LTAE VSAMGEEEQ------RLEQLIQG--CSLD---MRRMSELQSNQK------------------------------------ --------------------------------YAYVTY-----QDIKQLGNLRD-QTVIVVKAPTDTKLEVADP------ --------------DEN-LSIHLTSTKG-PIEVLLCPDEENDP------------------------------------- --------------RSPVKDGGMDINGNSPFLKVLQG------------------------------------------- ------------------------PTCSSASTIQSLAPP----------SSSSAVS------------------------ ---VTTLSPISSPY------------------------------------------------------------------ ------------------------TSLLQQTEDQIASSL-G------------------PFLNLGLPLLGQEDYTLDLGD EHGISDLF-DACDFDKMPSLGLDDLLCS >Ciona_intestinalis_E2F3 --------------------------------------------------MDNSRVFSTTTAREIFTNNLASVSPQCSSK SLPSNELHLTPSQDDTHQWLYGGHDMHGATDMSIVTVESQNNRNTAQVKRKLELQ------------------------- ----------SSSSGSMNSYLMSESQIQQLQTQNFVNN--------YNKPPSFKSPLKRAKSVSERKVLATNPPSR---- KRKMSTAGSVASGSPS-------------------EKSRYDTSLGLL-TKRFTQLMRNSSDGILDLNQAADILAVQ-KRR IYDITNVLEG-IGLIEKRSKNNVQWVAC--------------------PNTESDHSSEIEKQ-------------ETQNE VDALRNKEE------ELDQLIRK--RQME---LERLSESNTEHSYV---------------------------------- --------------------------------TYQ---------DIRGIKSFKE-QIVICIKAPQDTKLEVP-------- -------------DPGEKIQMLLKSTKG-EIDVFLCP--DPQD------------------------------------- --------------HISPKKEPVEGDSGLLEST----------------------------------------------- -------------------------------------------------------------------------------- ------SVSDGSQR------------------------------------------------------------------ ------------------------LS-GSQYEENRPLFMQTEDQMPSDEVD--SAFIDEDSFIALSPAMNPDDYLFSLDD SEGISELFDMNATSLSGARTS------- >Ciona_savignyi_E2F3 --------------------------------------------------MDNSRVFSTTTAREMFTNNLASISPHCSNK TF---EFHASPSLEHTHQWLPGGHDLAGVSDISIMSVESQSNRTSNQVKRKLELP------------------------- ----------SHSPG-QSPYYMSESQLQQLHNQQLTN---------YNKPSSFKSPLKRGKSAMERKVLATNPPIR---- KRKNSSTNAAMAGSPS-------------------EKSRYDTSLGLL-TKRFIQLMKSSSDGILDLNHAAEILSVQ-KRR IYDITNVLEG-IGLIEKRSKNNVQWVDA--------------------QKCDDEQVNEEEKR-------------ESELE LASLRKQEE------QLDTLIRK--RQLE---LERLSESNNEYPFY---------------------------------- --------------------------------FSQLLD-----IYIRGIKSFKD-QIVICIKAPQDTKLEVP-------- -------------DPGEKIQMLLKSTKG-EIDVFLCP--DPHD------------------------------------- --------------NMSPKKS--QSDS-CLGDT----------------------------------------------- -------------------------------------------------------------------------------- ------LEEDRSQR------------------------------------------------------------------ ------------------------ISPNGKYEDTKPLLMQTDDCIPSDEVD--SAFIDEDSFIALSPSVNPDEYLFTLDD SEGISELFDINSTSLSAPPSS------- >Branchiostoma_floridae_E2F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------KSPLEKTRYDTSLGLL-TKKFVGLLGSSPDGIVDLNQAAEVLNVQ-KRR IYDITNVLEG-INLIKKKSKNHIEWR----------------------VQSTMEKDKERLN---SAIG--------LFKT VDTEHIREN------LLDELIRH--SSTQ---LKHLTEDSENKKYPFQ-------------------------------- -----------------------------HGEHYCKCR-----NDIRSIKTFEE-QTVIAIKAPPETRLEVPDP------ --------------RES-IQIWLKSSKG-PIEVYLCPEE--QN------------------------------------- --------------TEDAGSSSSDAASS---------------------------------------------------- ---------------------------EGCSSTSG---------------SPCSVK------------------------ ---GSELKTNEMA------------------------------------------------------------------- ------------------------RSLLPQTEDQDQEIQD--------------------FVALSPPLME-DDYLFSLSP GEGISDLF-DAYDL-------------- >Saccoglossus_kowalevskii_E2F3 ------------------------------------------------------------------------------MP RGQPMQTVSRPAIPTLT--------ITKSTVANTTYGEVSR----GITIKGVTQ-------------------------- -------IQELEPIYTVKALQQHQEILSQVGCTPDLQ-TKVIKPTIGRPPQ--------------AKRKLDLD-----AT AAMLDDGFKSPRGGRK----KPRPSPKGS-AQSPAERTRYDTSLGLL-TKKFVGLLRSAPEGVLDLNYAAEVLEVQ-KRR IYDITNVLEG-INLIAKKAKNNIEWKG---------------------SSNSIASNGQEGSVCASSVD--------LNAE IFDLEAKEN------RLDELIKS--CTLQ---LKMLTEDANNGK------------------------------------ --------------------------------YPL--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------- >Homo_sapiens_E2F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE IEELQQREQ------ELDQHKVW--VQQS---IRNVTED--VQNS----------------------------------- -------------------------------CLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG---- LNGQK------------KYQIHLKSVSG-PIEVLLVNKEAWSS------------------------------------- ---------------PPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQ------------------------------ EASRPNSPQL-TPTA--VPGSAE---------VQGMAGPAAEITVSGGPGTDSKDSG-ELSSL------PLGPTTLDTRP LQSSALLDSSSSSSSSSSSSSNS-NSS-----------------------------------------SSSGPNPSTSFE PIKADPTGVLELP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE SEGVCDLFDVPVLNL------------- >Pan_troglodytes_E2F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MAEA-PQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE IEELQQREQ------ELDQHKVW--VQQS---IRNVTED--VQNS----------------------------------- -------------------------------CLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG---- LNGQK------------KYQIHLKSVSG-PIEVLLVNKEAWSS------------------------------------- ---------------PPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQ------------------------------ EASRPNSPQL-TPTA--VPGSAE---------VQGMAGPAAEITVSGGPGTDSKDSG-ELSSL------PLGPTTLDTWP LQSSALLDSSS------SSSSNS-NSS-----------------------------------------SSSGPNPSTSFE PIKADPTGVLELP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDD SEGVCDLFDVPVLNL------------- >Mus_musculus_E2F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE IEELQQREQ------ELDQHKVW--VQQS---IRNVTED--VQNS----------------------------------- -------------------------------CLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG---- LNGQK------------KYQIHLKSMSG-PIEVLLVNKEAWSS------------------------------------- ---------------PPVAVPVPPPDDLLQSPPAVSTPPPLPKPALAQPQ------------------------------ ESSPPSSPQLTTPTP--VLGSTQ---------VSEVACQTSEIAVSGSPGTENKDSG-EVSSL------PLGLTALDTRP LQSSALLDSSSSSSSSSSSSSSSSS----------------------------------------------GPNPSTSFE PIKADPTGVLDLP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE SEGVCDLFDVPVLKL------------- >Rattus_norvegicus_E2F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE IEELQQREQ------ELDQHKVW--VQQS---IRNVAED--VQNS----------------------------------- -------------------------------CLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG---- LNGQK------------KYQIHLKSMSG-PIEVLLVNKEAWSS------------------------------------- ---------------PPVAVPVPPPDDLLQSPPAVSTPPPLPKPALAHPQ------------------------------ ETSRPSSPQITTPTP--VLGSTE---------VSDVAGQTAEIAVSGSPGTENKGSG-ELSSL------PLGLTALDTRP LQSSALLDSSSSSSSSSSSSSSSSSSS--------------------------------------------GPNPSTSFE PIKADPTGVLDLP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE SEGVCDLFDVPVLKL------------- >Canis_familiaris_E2F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE IEELQQREQ------ELDKHKVW--VQQS---IRNVTED--VQNSPH--------------------------------- -------------------------------TLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG---- LNGQK------------KYQIHLKSVSG-PIEVLLVNKEAWSS------------------------------------- ---------------PPVAVPVPPPEDLLQSPPAVSTPPPLPKPTLAQPH------------------------------ DTSRPSSPQLTTPTP--VTGITE---------AQGVPGPAAEIAVSGGPGTDSKDGG-ELGSL------PPGLAALDTRP LQSSALLDSSSSSSSSSSSNSSSSG-----------------------------------------------PNPSTTCH PVAPAPIEFLELP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE SEGVCDLFDVPVLNL------------- >Myotis_lucifugus_E2F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE IEELQQREQ------ELDQHKVW--VQQS---IRNVTED--VQNSPH--------------------------------- -------------------------------TLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG---- LNGQK------------KYQIHLKSVSG-PIEVLLVNKEAWSS------------------------------------- ---------------PPVAVPVPPPEDLLQSPSALSTPPPLPKPAVALPQ------------------------------ DASHPSSPQVTSTTTICVPAGVE---------AQGMAIPAAEIIVSGGPGSDSKDSG-ELSSL------SLGPAALDTRP LQSSALLDSSSSSSSSSSSSSSSSS----------------------------------------------GPNPSTSFE PIKVDPTGVLELP--------KELSEIFDPTPECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE SEGVCDLFDVPVLNL------------- >Monodelphis_domestica_E2F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------P--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE IEELQQREQ------ELDQHKVW--VQQS---IRNVTEDTFCLFSLTPA------------------------------- -------------------------------TVAYVTH-----EDIC--KCFTG-DTLLAIRAPSGTSLEVPVPEG---- LNVQK------------KYQIHLRSATG-PIEVLLVNKDAWSS------------------------------------- ---------------PPVVVPVPPPEDLLQFQAAIPSPPQ-PRPAPSQHP------------------------------ ETSIPSSPCPSTPTS---TQDQS---------AIGQPTASPVAGSSSGPGADSKDAS-VLGTLN-----TASPAALDTRP LQSSASLDSSST-----------------------------------------------------------LPNPSTSFE PIKPDPTGILELP--------KELSEMFDPTRECMSSGLLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE SEGVCDLFDVPVLNL------------- >Gallus_gallus_E2F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MAECGPQPPGAGGGGGG------GGGGGSGGAGAPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIAHKLI-ELK----------------AD IEDLEQQEQ------ELEKQKMW--VQQS---IKNVTED--VQNN----------------------------------- -------------------------------WLAYVTH-----EDIC--KCFTG-DTLLAIRAPSGTRLEVPIPEG---- PSRQK------------KYQIHLKSTSG-PIDVLLVNKDAWSS------------------------------------- ---------------PPVVLPVPPPEDLIQCQAVAPSKPQ--IPPLAHFQ------------------------------ EASVPSSTQPSTPTP---SSTQD---------HSPPEQKDT-STECSISVVESKSSSSDLDPLSNVSAPSGHTARLDTQL LQSSASLDSSSVL-----------------------------------------------------------PSPSASFE PIKPDPAGMLELP--------KELSEMFDPTRECMNSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE SEGVCDLFDVPVLNL------------- >Anolis_carolinensis_E2F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MAADSGAQPPG----------------------GGPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIAHKLI-ELK----------------AE IEDLEQRER------ELEQQKIW--VQQS---IKNVTDD--VQNS----------------------------------- -------------------------------RLAYITD-----EDLC--KCFPG-DTLLAIRAPSGTQLEVPVPEG---- LNGQK------------KYQIHLKSTSG-PIDVLLVNKDAWSS------------------------------------- ---------------PPVVLPVPPPEDLIQCQLATPSKPH--RPALH--------------------------------- --SVPSRSQPSAPVP---SSTQD---------HVCATLKTAGATESDISITEPKSVG-ELDPLTPPAAPIILPAGLDTQP LQSSASLDSGSVL-----------------------------------------------------------PSPSTSFQ LIKPDPTEILELP--------KELSEMFEPDRECMNSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE SEGVCDLFDVPILNL------------- >Takifugu_rubripes_E2F4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -LGAVGDSLQPQ----------------------TPSR-HEKSLGLL-TTKFVTLLQEAKDGVLDLKAAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-DLK----------------AE LDDLALREH------ELDQQRVW--VQQS---IKNVTDD--SNNSPL--------------------------------- -------------------------------TLAYVKH-----EDLC--GAFKG-DTLLAIRAPIGTQLEVPIPESVGYI PNGQR------------KYQIHLKSSTG-PIEVLLVNKDPSSA------------------------------------- ---------------SPVVLPVPPPDEILQSLP-TPALTPASQPSVSQVLK----------------------------S AAAASVKPAPVAAAIPPVPST-------ESMMVPSILISSWSSDGTTVQVSDAPSSSPLAPAT--------ETPVAATQQ LLSSASLDGSASS------------------------------------------------------------SASAVFE PVKSDPSELLDFP--------KELSDMFDPTKEIS-GDLLEDL----------MSSEVFSPLLRLSPPPSDHDYIYNLDE TEGLCDLFDVPILNL------------- >Gasterosteus_aculeatus_E2F4_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -STQPVRLTLPQ----------------------TPSR-HEKSLGLL-TTKFVTLLQEAKDGVLDLKAAADTLAVRQKRR IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-DLK----------------AE LDDLALREN------ELDQQRVW--VQQS---IKNVTDD--SNNSP---------------------------------- --------------------------------YPSLQH-----EDLC--GAFKG-ETLLAIRAPIGTQLEVPIPESV--V LNGQR------------KYQIRLKSSSG-AIEVLLVNKDPSSS------------------------------------- ---------------SPVVLPVPPPDDILQSLP-VPTPTSQPPTAVPQY-R----------------------------L LSSFTSSFRPSVLQNCSSND-------------------------CKTRPGRNNSCS---SHR--------DNPSISTQQ LQSSASLDGSASS------------------------------------------------------------SASAGFQ PIKSDPSELLDFP--------KELSDMFDPTKEIISGDLLEDL----------MSSEVFSPLLRLSPPPSDHDYIYNLDE TEGLCDLFDVPILNL------------- >Homo_sapiens_E2F5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MAAAEPASSGQQAPAGQGQGQRPPPQP PQAQAPQPPPPPQLG----------------GAGGGSSRHEKSLGLL-TTKFVSLLQEAKDGVLDLKAAADTLAVRQKRR IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVIDRLR-YLK----------------AE IEDLELKER------ELDQQKLW--LQQS---IKNVMDDS-INN------------------------------------ -------------------------------RFSYVTH-----EDIC--NCFN-GDTLLAIQAPSGTQLEVPIPEM---G QNGQK------------KYQINLKSHSG-PIHVLLINKESSSS------------------------------------- ---------------KPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQN------------------------------ -----------LPEQ---------------------------------HVSERSQA------------------------ LQQTSATDISSA-------------------------------------------------------------------- --------------------------------GSISGDIIDEL----------MSSDVFPLL-RLSPTPAD-DYNFNLDD NEGVCDLFDVQILNY------------- >Gorilla_gorilla_E2F5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MAAAEPASSGQQAPAGQGQGQRPPPQP PQAQAPQPPPPPPLG----------------GAGGGSSRHEKSLGLL-TTKFVSLLQEAKDGVLDLKAAADTLAVRQKRR IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVIDRLR-YLK----------------AE IEDLELKER------ELDQQKLW--LQQS---IKNVMDDS-INNS----------------------------------- -------------------------------TFSYVTH-----EDIC--NCFN-GDTLLAIQAPSGTQLEVPIPEM---G QNGQK------------KYQINLKSHSG-PIHVLLINKESSSS------------------------------------- ---------------KPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQN------------------------------ -----------LPEQ---------------------------------HVSERSQA------------------------ LQQTSATDISSA-------------------------------------------------------------------- --------------------------------GSISGDIIDEL----------MSSDVFPLL-RLSPTPAD-DYNFNLDD NEGVCDLFDVQILNY------------- >Mus_musculus_E2F5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MAAAEPTSSAQPTPQAQAQ-------P PP---HGAPSSQPSA----------------ALAGGSSRHEKSLGLL-TTKFVSLLQEAQDGVLDLKAAADTLAVRQKRR IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVIDRLR-CLK----------------AE IEDLELKER------ELDQQKLW--LQQS---IKNVMEDS-INNR----------------------------------- --------------------------------FSYVTH-----EDIC--NCFH-GDTLLAIQAPSGTQLEVPIPEM---G QNGQK------------KYQINLKSHSG-PIHVLLINKESSSS------------------------------------- ---------------KPVVFPVPPPDDLTQPSSQSSTSVTPQKSTMAAQN------------------------------ -----------LPEQ---------------------------------HVSERSQT------------------------ FQQTPAAEVSS--------------------------------------------------------------------- --------------------------------GSISGDIIDEL----------MSSDVFPLL-RLSPTPAD-DYNFNLDD NEGVCDLFDVQILNY------------- >Rattus_norvegicus_E2F5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MAAAEPTSSAQPTPQAQAQ-------P PPPPPHGAPSSHQSA----------------ALAGGSSRHEKSLGLL-TTKFVSLLQEAQDGVLDLKEAADTLAVRQKRR IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVIDRLR-CLK----------------AE IEDLELKER------ELDQQKLW--LQQS---IKNVMEDS-INNR----------------------------------- --------------------------------FSYVTH-----EDIC--SCFN-GDTLLAIQAPSGTQLEVPIPEM---G QNGQK------------KYQINLKSHSG-PIHVLLINKESNSS------------------------------------- ---------------KPVVFPVPPPDDLTQPSSQSSTSVTPPKSTMAAQN------------------------------ -----------LPEQ---------------------------------HVSERSQN------------------------ FQQTPATEISS--------------------------------------------------------------------- --------------------------------GSISGDIIDEL----------MSSDVFPLL-RLSPTPAD-DYNFNLDD NEGVCDLFDVQILNY------------- >Myotis_lucifugus_E2F5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MAAAEPASSGQSAPQGQAQVQ------ -WAPPASPAPPPQLG----------------ARGGARGRRRGCGPRC-TRLFIRQLQGAGMGVPDAGEAADTLAVRQKRR IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVLERLR-DLR----------------AE VEDLDLKER------ELDQQKSW--LQQS---IRNVMDDT-INSRR---------------------------------- ------------------------------RTFSYVTH-----EDIC--NCFH-GDTLLAIQAPAGTQLEVPLPEM---G QNGQK---------