>Homo_sapiens_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MAEQQGRELEAECPVCWNP------------------------------------------------ -------FNNTFHTPKMLDCCHSFCVECLAHLSLVTPARRR--------------------------------------- LLCPLCRQPTVLASGQ-----PVTDLPTDTAMLAL--------------------------------------------- -------------------------------------------LRLEPHHVILEGHQLCLKDQPKSRYFLRQPQVYTL-- ----------DLGPQPGGQTG-----------------PPPDTASATVSTPILIPSHHSLRECFRNPQFRIFAYLM--AV ILSVTLLLIFSIFWTKQFLWGVG--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Pan_troglodytes_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MAEQQGRELEAECPVCWNP------------------------------------------------ -------FNNTFHTPKMLDCCHSFCVECLAHLSLVTPARRC--------------------------------------- LLCPLCRQPTVLASGQ-----PVTDLPTDTAMLTL--------------------------------------------- -------------------------------------------LRLEPHHVILEGRQLCLKDQPKSRYFLRQPRVYTL-- ----------DLGPQPGGQTG-----------------PPPDTASATVSTPILIPSHHSLRECFRNPQFRIFAYLM--AV ILSVTLLLIFSIFWTKQFLWGVG--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Macaca_mulatta_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MAEQEGRELEAECPICWNP------------------------------------------------ -------FNNTFHTPKMLDCCHSFCVECLAHLSLVTPAQRR--------------------------------------- LLCPLCRQPTVLALGQ-----PVTDLPTDTAMLTL--------------------------------------------- -------------------------------------------LRLEPHHVILEGRQLCLKDQPKSRYFLRQPRVYTL-- ----------DLGPQPGGQTG-----------------PPPDTASATVPMPIPIPSHYSPRECFRNPQFRIFAYLM--TV ILSVTLLLIFSIFWTKQFLWGVG--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Mus_musculus_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MSEPQGQELRAECPVCWNP------------------------------------------------ -------FNNTFHTPKVLDCCHSFCVECLAHLSLVTPARRR--------------------------------------- LLCPLCRQPTVLASGQ-----PVTDLPTDTAMLTL--------------------------------------------- -------------------------------------------LRLEPHHVILEGHQLCLKDQPKSRYFLRQPRVYTL-- ----------DLGAEPGSQTG-----------------LPQDTAPDTR--PVPIPSHYSLRECVRNPHFRIFAYLM--AV ILSVTLLLIFSIFWTKQFFWGMG--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Rattus_norvegicus_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MSEPQVQELKAECPVCWNP------------------------------------------------ -------FNNTFHTPKVLDCCHSFCVECLAHLSLVSPARRR--------------------------------------- LLCPLCRQTTVLASGQ-----PVTDLPTDTAMLTL--------------------------------------------- -------------------------------------------LRLEPHHVILEGHQLCLKDQPKSRYFLRQPRVYTL-- ----------DLGPEPGSQTG-----------------LPQDTAPDTR--PVPIPSHYSLRECVRNPHFRIFAYLM--AV ILSVTLLLIFSIFWTKQLFWGMG--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Bos_taurus_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MAEQQGREP--ECPVCWNP------------------------------------------------ -------FNNTFHTPKVLDCCHSFCVECLAHISLVTPTRRR--------------------------------------- LLCPLCRHPTVLASGQ-----PVTDLPTDTAVLTL--------------------------------------------- -------------------------------------------LRLEPHHVILEGHQLCLKDQPKSRYFLRQPRVYTL-- ----------DLGPEPASQAG-----------------QPQDVGPSTR--PVPIRSRYSLRECFRNPHFRIFAYMM--AV ILCGTVLFIFSIFCTRRFFWGVG--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Anolis_carolinensis_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MSCFTQIWRTEVPESPPPSPTSPVPAAP---------HEIPIPL SPG-----------SPTDRPTSPIECSICFNT------------------------------------------------ -------YDNLFKTPKVLRCNHTFCLECLARLAAARPRSCL----ED--------------------------------E LPCPFCRQITEIPLE------GPPGLQTSKDLMAT-LP------------------------------------------ ------------------------------------------PEHQREKMIWMEGTKICCR-QSS-DPENADACISID-- ----------IAPSKPEVPQLPP---------------ETFM-----------GRLTRCDM-CDDWKRVLLLSVLI--II LFCIILWPLHCAMKTGNLRC------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Xenopus_tropicalis_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MADAVKLDPDWDCPVCWNP------------------------------------------------ -------YNPTSRTPKLLHCNHCFCLECLERLSQASPMR----------------------------------------- IPCPLCRHPTVLPEGQ-----GVPALPTHSAILSQ--------------------------------------------- -------------------------------------------VRAEQPTP---RPFFCPKDSLKLPLFQRPPSIYTV-- ----------SVGEEPG---------------------PPFNSQS-----PLTLPSTGPPWHCFRNPQLRMFSYLM--LV IAGVTLFLIFSIFWTRKFIWGQR--------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Danio_rerio_RNF183_b -------------------------------------------------------------------------------- ----------------------------------------------------------------------MGDRRE---- -----KPQSSRKGSNAKPKLESKGSLNLGSSEQRQRADKPVRRSRSNDTENRRREGSRGRERDRRDEGRPQRGRSEEGRR RGHNHEPGNRAWDKERPKDELQDTECIVCFCN------------------------------------------------ -------FDNVFKTPKLLSCGHTFCLECLARINVNSPEIKT--------------------------------------- LTCPICREVTEIRHGR-----DLPHLLNNEAIFRQ-LP------------------------------------------ ------------------------------------------SEMQRALSVRFKRSKGKLVLKNPP-TNNSIKTTLNL-- ----------PVLKKKEEQAGNN----------------AIGAIEEGLGQATMINVGRPPNRMRGRMRRVMYSSQC--YY AVVAVIISITVALMMVGIFTFVVMPNLQRPITKPLQN--QTGSSAVQADSSP---------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Takifugu_rubripes_RNF183_a -------------------------------------------------------------------------------- ----------------------------------------------------------------------PGGSQS---- -----QSQQTRPAVNVKPKPTQK---EIRYSQTQWKKEKPAKVRRSRSSDSERVERGRRSNKERHHGERRRRGRSEETHR PDRREN-RDEGSKAGPPPDDMEDTECAVCFCT------------------------------------------------ -------YDNVFKTPKLLACGHTFCLECLARINVTSAELKT--------------------------------------- LSCPICRELTKLPHGK-----DLPRLGNNLDIIDK-LP------------------------------------------ ------------------------------------------PDMHRALSIRFQRSKGKLLLKNPPPTSPTKSNLLTL-- ----------PVKSQGGP-VTPE---------------GNLDAMEQGIVPTTVVDVGRPPSRIRGRLRRVFRSDQC--YY AVVGSIITITVVLMLVGLLAFVIIPKVPVFQSPTPAGNHTSGHTGASGGSSP---------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Tetraodon_nigroviridis_RNF183_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------ECSICYTT------------------------------------------------ -------YDNVFKTPKELDCTHTFCLECLSRLMALSPADQDSDHPLK--------------------------------H ISCPLCRRTTTLPKE------GPPALTTNHEVLRK-LP------------------------------------------ ------------------------------------------HHQQ---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Tetraodon_nigroviridis_RNF183_b -------------------------------------------------------------------------------- ----------------------------------------------------------------------QSQSQS---- -----QSQQPRPAANVKPKPPQK---EIRHSQTSWKKEKPAKARRSRSSDSE---RGRRRDSERHHGERRRRGRSEETQR RDRGGG-GTERSRAGPPQDDIEDTECAVCFCT------------------------------------------------ -------YDNVFKTPKLLACGHTFCLECLARINVTSAELKT--------------------------------------- LSCPICREVTRLPHGQ-----DLPRLGNNLDIIDK-LP------------------------------------------ ------------------------------------------PDMHRALSIRFKRSKGKLLLKNPPATSPTKASTLTL-- ----------PVKSQGDAGVHPE---------------GSPGAMEQGMVSATVVDVGRPPSRIRGRMRRLFRSDQC--YY AVVGSIITLTVLLMLVGLLAFVIIPKV----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Oryzias_latipes_RNF183_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------MAKDDMAEV ELPSTGAEPPGE--ASSAFPYEEYECKICYNY------------------------------------------------ -------FDLDRRAPKILECLHTFCEECLN-TLHLREERPW--------------------------------------R ISCPVCRHRTPVPDY------RIQNLPNNTKVTEDFPLYIDSDPLPQ--------------------------------- ------------------------------------------DALPPFPPPLH--PALVALRREEAS--GASSVSQAT-- ----------PSTTVSTATTLSQ---------------DSVRYDSCQSCKRVALTTGCVCVIFSFLSMLVLLFMGL--IF VHSHSIPPSPAGPICLSVASILAMFSVVVTWLICWLKYRPDHETGRASSTGNSRRNA----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Ciona_savignyi_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MENRRTHIEASDVDLALEE------------------------------------------------ ------------AGHCGLYHAWLILLMAVPNILVGAHMGSS--------------------------------------- VFEAMIPTHYCVTQQ-------ADDITTACNITWN--------------------------------------------- ----------------------------------------------------PTNDALAVPEDLDGKHSPCHMYYYDN-- ---------------------------------------------------------------VTDIDCKFWTLDK---- --NSTPTVEPGIRTCDHWIFD----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Drosophila_melanogaster_RNF183 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MNNSPKDPYRGGGGGSGPQDGAGSTGVSINIESDDNDSTTAEHDYLL PASSSSVTSGGGVGGGGVVSGGSTSTSVNLDH------------------------------------------------ -------QHVPTARSSSLSGGNVRHGNILSTFLARQRSYTPASNSSSP------------------------------VR VTTQMNRRLQQSRSMGANTGGSLEEPSSAGAAGGPGASPG---------------------------------------- -----------------------------------------TAAGVRQMGFWRVNLNDVFSLSTASSTEALRSFISHSN- --------FRYPPATTAAPAAPGP------------QPAANPVDNSHILLGQQQPSMPEPVSPLRYGRVSAVSGASSAGA MGRSISLREGEMRHNHSLNGGRHNASAIGLNSNPAAFDEREANESQDLDESDGNVENGGGGGNPPEPAENNPEDEHLISD DMVVQILSHFVRYLPLIFILFFKFLHDHLLGIVDLLVLQTVMYNVNRSVRNQVARLAQKNYAVMVR-------------- ------------------------------------------------------------------------DTFLVAVV VTVRLFLATSPPDPFGLIVPPSRKSVFIEVTALPFHTSSEGDSPTTSSEPIKTNMYKDTYKSLNVIPLGMLLYYIAVSDL IIKLLTMLVKLIITMLPHHLMRLKVRARLYVLVEYISQFYRAMTPITQWLLFLYESYSGLEVVSGGLFSAMYLGAKIFEL VERGKSLKKAIVTFRKNIDSERPPTKDELDAAGALCPICHDAFNTPTVLECGHIFCDECVQTWFKREQTCPMCRAKVSDD PAWQDGSTTFFHQLY----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Homo_sapiens_RNF223 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MSSGQQVWHTAVPPPRRSSSIASMPRSP---------SSAGSPR SP----------GTPGSERVASPLECSICFSG------------------------------------------------ -------YDNIFKTPKELSCTHVFCLECLARLAAAQPVGRPG---GE--------------------------------A VPCPFCRQPTAVPPA------GAPALCTSRQLQAR-MP------------------------------------------ ------------------------------------------AHLRREEPVWLEGTKLCCQPLPTTPGR-EPGFVCVD-- ----------VGLSKPAEP--PA---------------PARDPAPR------RGRLARCWARCRDWRRMALVSALL--LM LFCVALWPVQCALKTGNLRCLPLPPRPPATS--TAASPLGPLTDN----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Macaca_mulatta_RNF223 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------LSHSSETCRPASRCGTRPCPPIAGAAPQP---------RCPGPPA RLAA------PGPTPGSEKVASPLECSICFSG------------------------------------------------ -------YDNIFKTPKELSCTHVFCLECLARLAAAQPVGRPG---GE--------------------------------A VPCPFCRQPTTVPPA------GAPALRTSRQLQAR-MP------------------------------------------ ------------------------------------------AHLRREEPVWLEGTKLCCQPLPTTPGH-KPSFVCVD-- ----------VGLSKPAEPPAPA---------------QDPAPRR--------GRLARCWMRCRDWRRMALVSALL--LV LFCVALWPVQCAIKTGNLRCLPRQPPSPSSTGGSPTGGLKGAAATG---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Bos_taurus_RNF223 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MSSGPQVWHTTMPLTSRSSPTATVPRSP---------SSASSPR SP----------GTPGSEKVASPLECSICFSG------------------------------------------------ -------YDNIFKTPKELSCTHVFCLECLARLAAAQPTGQPG---SE--------------------------------A VPCPFCRQPTAVPAA------GAPALRTSRQLQAR-MP------------------------------------------ ------------------------------------------AHLQQEEPVWLEGTKLCYYPSPSVPGPVEPGFMCVD-- ----------IGPSKPPEPAVPV---------------PTPDPAHR------RGPLARCWARCRDWRRVALITALL--LV LFCVVLWPVQCALKTGSLRCL---PRPPSTA--ATTSSLGSLAYN----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Gallus_gallus_RNF223 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MSCFTQLWHSSTPDPIVITSPVDSKRKAR--------SPTDKPG SPN-----------PTSPKPASPVECSICFNT------------------------------------------------ -------YDNTFKTPKLLQCSHVFCLECVARLSKGLPPNHP----ED--------------------------------Q LPCPFCRQLTSIPQE------GAPALETSKELLAT-LP------------------------------------------ ------------------------------------------PELQQEKVLWMEGTKLCCR-QASDDPENPDSCISID-- ----------VAMSKPESPEVPP---------------TGLV-----------GRLSRCDM-CDDWKRIVLLSALI--II LFCIILWPVQCALKTGNLRCFTRPHGPQRP----FCAHTWMGALTSS--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Xenopus_tropicalis_RNF223 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------SRLECSICFTK------------------------------------------------ -------YDNIFKTPKLLQCSHTLCLECVARLVAALPPEKQ----AE--------------------------------D VLCPFCRQPTHIPDD------GAPALQTSQELLST-LP------------------------------------------ ------------------------------------------AHLQHEEPVWIEGNKLCYKKPPETNPDQHDLCICVD-- ----------IGLSKKDSPTEPR---------------QRR----------------GCFRGCSDWKRLLLIAFIV--AV LFCILLWPVECILKTGSLRCTS-EPVPTRIPVVPAVVTHGPIDER----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Gasterosteus_aculeatus_RNF223_a -------------------------------------------------------------------------------- ---------------------------------------MFPAPRSAAAALFHLTTPPDVPPPQQVPDSLPPPTHPSISN MSEDREGRAAAPPPNVKPKLGQT---ERRSKEGTWKKEKPPKERRSRSTHSEREDERRGRERDRHRGGRSRRGRSEEARG RDGRGS-ASG--RVKPPEDEVEDTECAVCFCS------------------------------------------------ -------YDNIFRTPKLLACGHTFCLECLARINVTSARLKT--------------------------------------- LSCPVCREPTELPHGR-----DLPRLGTNKDVLGR-LP------------------------------------------ ------------------------------------------PDMRRVLSIRFKRSKGKLQLKNPPPAGRDKNSVRQP-- ----------SKIQGGAVPAGGH---------------SDLSALE----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Gasterosteus_aculeatus_RNF223_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------IELQSPEVDAPSADELECKICYSA------------------------------------------------ -------YNLAARRPKVLGCCHRLCAKCLAKILDLGESPPD--------------------------------------A VACPFCRYVTGLPGQ------AVSGLPDDCNLAAALALQSRNQRNLHS--------R----------------------- ------------------------------Q-----------EATTELLLSPGLLSSLMGGGPPTTGSPNFVVITIME-- ----------TPPPPMPLPASGED--LRRQPRGPRGGFRSSSLDSTASIAHRWTAWNCASQLCQTSARVLVWVLGL--LY FS--SLPMGVYLLIMQRTTVGLLLVSLVPASLVVIMVYGFCQCVYHELWDCVPP-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Branchiostoma_floridae_RNF223 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MASSLLSQISEDFLKCQICHDT------------------------------------------------ -------FKR----PKVLSCLHTFCLQCLKSYLKKNPRVSIK-------------------------------------T FLCPLCRQETATPPT------GADGLKDNFFVSNLLEA------------------------------------------ ------------------------------------------LSTLKTFKVKGFVACGGCSRSASSRCMECEDFLCVHCH G----------VHAKLKVTRDHT-------------VLSIRELSSEGGSAQIRAYTKATLCPVHEGETMRFYCETC--QK PICRDCTVLDHSKPDHKYVYFKDALSSRKDEIQDLLTSCRGMVEGLEETKERLESEEGELRETKEGTLKDIEEWVAGLVL DTQRKKEELKDQVETIYNEQLKELSAAKSRVEMTLNDIDSGCGFSEKVLDIGTDFEILSMRN------------------ -------------------------------------------------------------------------------- -------------EMAARLSDLTKMERPKVDQNRSGLIKFRPYGGIGELVKLGVGELDSRTVGELVVKFGGWGPQQGQFK HPGGVAVSSAGHIIVADTGNHRIQV---FDSRGVFLRAFGFYGSADDAFSHPHDVAM-----TTDDRILVTDKGNKLVKL F-------------------------TLEGKLIGKIGTGNLKEPTGVAVYKHGGVAVTDTRDVKTFTRTGVMSATCTSDD PGYSHYLCTDDEGRCSKCSL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Homo_sapiens_RNF225 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MPCPRPFWLRHSRAPQGSGPSSPGSLSAPRSPSR-GEDQEEEEEEE GDGSPG-------SGPILPPASPVECLICVSS------------------------------------------------ -------FDGVFKLPKRLDCGHVFCLECLARLSLATAGGGN--------------------------------------A VACPVCRAPTRLAPRR-----GLPALPTQSGLLPRDAR------------------------------------------ ------------------------------------------APPSRQGSVRFDRRRGLLYLRPPPPPPGPRKARA---- -----------PPPPPPLRLGRP---------------LSRRLS----------LASPAWVFNAAVALAVLVAAGL--VV SGVYIFFLIPHATSSGPPRPQLVALAPAPGFSWFPPRPPPGSPWAPAWTPRPTGP--DLDTALPGTAEDALEPEAGPEDP AEAERTLDRRSDGTWGTEAGPGWAPWPRGARRLWGSQ------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Macaca_mulatta_RNF225 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MPCPRPFWLRHSRAPQGSGPSPP---------SR------------ -DGSPG-------SSPILSPASPVECLICVSS------------------------------------------------ -------FDGVFKLPKRLDCGHVFCLECLARLSLATAGGGN--------------------------------------A VACPVCRAPTRLAPRR-----GLPALPTQSGLL----------------------------------------------- ----------------------------------------------------------------------PRDARA---- -----------PPS----RQGS-----------------VRFVS----------LASPAWVFNAAVALAVLVAAGL--VV SGVYIFFLIPHATSSGPARPQLVALAPAPGFSWFPPRPTPGVPWTPAWTPRPTGP--DLDTTLPGTAEDALEPQAGPEDP VENEGTLDRPSDGTWGTEADPGWAP------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Mus_musculus_RNF225 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MPCPRLPWLRRHRTSQGSGPSSPSTVSAPNSPSR--GEDEDAEEEE GDGTPG-------SGPILPPTSPMECLICVSP------------------------------------------------ -------FDGIFKLPKRLDCGHVFCLECLARLSLATAGGGD--------------------------------------A VACPMCRAPTRLAPRR-----GLPALPTQPGLLPRDAR------------------------------------------ ------------------------------------------APLPRQGSVRFDRRRGLLYLRPPPPSPGPRKSRTVR-- ----------APPPPPPLRLGRP---------------LSRRLS----------LSSPAWAFNAAVALAVLVAAGL--VV SGVYIFFLIPHVTNSG-VRPQTVALAPENDF-WVSPRPTPVAPWTHAWTRRPTKPDLDLDDTLPEATKDTPELEEATKDP VETQGIPDLPPDQTPKAEIDLNWNPKAQADGKKVQLQQ------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Rattus_norvegicus_RNF225 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MPCPRLPWLRRHRTSQGSSPGSPSTLSAPNFPSR--GEDEDAEEEE GDGTPG-------SGPILPPASPMECLICVSP------------------------------------------------ -------FDGIFKLPKRLDCGHVFCLECLARLSLATAGGGD--------------------------------------A VACPMCRAPTRLAPRR-----GLPALPTQPGLLPCDAR------------------------------------------ ------------------------------------------APLPRQGSVRFDRRRGLLYLRPPPPSPGPRKSRTVR-- ----------APPPPPPLRLGRP---------------LSRRLS----------LSSPAWAFNAAVALAVLVAAGL--VV SGVYIFFLIPHVTTSSPARPQIVALAPENGF-WVSPRPTPVAPWTHTWTRRPTKP--DLDDTLTETTKDTPEL-EATKGP VEIQETPDLSPDQTPNAETDLSWDRKAWTDGKRVQLQQ------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Danio_rerio_RNF225_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------KVSSHPECSICFNT------------------------------------------------ -------YDNVFKTPKQLDCTHTFCLECLSRIMTTSMDPQNS-------------------------------------K IPCPFCRQPTTIPKK------GPPALTTSQEVLCR-LP------------------------------------------ ------------------------------------------IHQQHEEPVWLDGERLCYQRPIEMPGV-PAFCICVD-- ----------IGASGHSGVSSSQ---------------TRPR--------------LSLMERMMDWKRLLIFIFLM--VL LLGIVLWPLQCIVTTGSLRCSPQNMHMSTTTASTTTVTMLLLLGDE---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Takifugu_rubripes_RNF225_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---LKMKCAQTDIEE-DCPPPDEIECKICYQH------------------------------------------------ -------YNAYKRKPKILDCLHRVCTQCLNKILDVAEG-AG--------------------------------------F ILCPFCRHQTPITDS------EVSALPDDANIMSRLAM--QEKSWSS--------------------------------- ------------------------------------------DHTGEVLLTP---KSFSS-SSPSPDSSSCLVITMTE-- ----------EQRDSEHAPRQN------------SAIYPEQSLESVSVGSDGHVDQYATSKLCHHVPRTLVWLLGF--LY FG--SLPLGIYLLVLQKVTLGIVSVSLVPTSLTVCLVYEFCS-VCDNSVDCMYTL------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Gasterosteus_aculeatus_RNF225_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MSG-AQAEIEEKDSPPPEELECKICYQR------------------------------------------------ -------YNAHHRRPKVLDCLHRVCVRCLIKILDIADG-TD--------------------------------------F ISCPFCRHQTEVSEY------EVSALPDDAIIMSRLAM--RDKSWSS--------------------------------- ------------------------------------------DKNREVLLTP---TSFSS-SSPSRDSSNCLVITIME-- ----------VQGDSQRSPTRDG----------SSDVFAEQSLDSVSMGSNGLADQDALSKFCNHVPRILVWLLGF--LY FG--SLPLGIYLLVIQRVTLGIACVSLVPSSLTVCLVYGFCQCLCQGMCDCYS--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Oryzias_latipes_RNF225_a -------------------------------------------------------------------------------- -----------------------------------------------------------------MNEGREAGGPP---- -----GGNDPPLAPNVKPKPNQN---VKNTKEEHRSKKKTVKVKRSRSTDSQRGERGRRRERER---ERGSRGRSEDTQR RER---------RRKPPENDVEDTECSICFCS------------------------------------------------ -------YDNIFKTPKVLACGHTFCLECLARINVTSAELKN--------------------------------------- LPCPVCREVTELRHGR-----DLPRLDNNQEIIQK-LP------------------------------------------ ------------------------------------------SQMQRARSIR---------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Oryzias_latipes_RNF225_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MIGPQLEEVGDKDCPSPEELECKICYQR------------------------------------------------ -------YNAHNRKPKILDCLHRVCARCLLKILDVADG-GG--------------------------------------S IPCPFCRHQTEISEY------QVSALPDDVNIMSHLE-----KSSSS--------------------------------- ------------------------------------------DQNREVLLTP---QSFSS-SSPSRDSSNCLVITIME-- ----------VQRDSGHSPSQNG----------SSDIYAEQSLDSVSIGSNGPADHDALTKLCNHVPRILVWLLGF--LY FG--SLPLGIYLLVIQRVTLGIVCVSLVPSSLTVCLVYGFCQCLCQGMCDCSSRG------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------- >Ciona_intestinalis_RNF225 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MAGA-KSLKNKLEDDLLTCPICCSL------------------------------------------------ -------YND----PRVLKCQHSFCHGCLKGSMKAAKSNGK--------------------------------------S INCAVCRKPTPLAKK------GLADLPKNYVIIGLSQMVKEHKESGKSPVVAK-SSS----------------------- ------------------------------G-----------KNVGNVKQLVETFNKKSIVEKPSKKRDKNFNIEVPKAG VVHDDENDDSSDLSTSASDSSGMT--EFTPTDDSESTSSGSDDSSSGSDDSDTDSESDSGSSDDEEPEHVPQRPTI--KS SHGIKLGMKVFVFTAKGKPLPGTVRVLEKYKRKPPNQTQVYAGVQMEKEYKKLTTEDILDMDDSYLFNWLMDFDQPCVAV RIDQCCPAKVIQRFNL---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------