>Homo_sapiens_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSLPSRQT------------AIIVNPPPPEYINTKKNGR-----LTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK LQLPDYYTIIKN--------PMDLNTIKKRLENKYYAKASECIEDFNTMFSN-CYLYNKPGDDIVLMAQALEKLFMQKLS QMPQEEQVVG---VKERIKKGKAG-----------------------------------GTQQNIAVSSAKEKSSPSATE KVFKQQEIP-------------------------------SVFPKTSISPLNVVQGASVNSSSQTAAQV----------- -------------------------------------------------------------------------------- -----------------------TKGVKR-KADTTTPATSAVKASSEFSPTFT--------------------------- --------------------EKS-VALPPIKENM------PKNV----LPDSQQQ----------------YNVVKTVKV TEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY KYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKT------------------------DITETTGR------ ---ENTNEASSEGN------------------SSDDSEDERVKRLAKLQEQ----------------------------L KAVHQQLQVLSQVPFRKLNK-KKEKSKKEKKKEKVN-------------------------------------------- -------------------------------------------------------------------------------- -----NSNENPRKMCEQMRLKEKSKRNQ---------------------------------------------------- --------------------------------PKKRKQQFIGLKSED---------EDNAKPMNYDEKRQLSLNINKLPG DKLGRVVHIIQSREP-----SLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKP-----------PAKKIMMSK EELHSQKKQELEKRLLDVNNQLNSRKRQT----KSDKTQPS----------KAVENVSRLSE------------------ -------------------SSSSSS---------------SSS-ESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPS- KENVKKMKN-----ECIPPE--------------GRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQEL EHLQTVK-NISPLQILPPSGD-----SEQLSNG----------------------------ITVMHPSGDS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------DTTMLESECQAPVQKDIKIKNADSWKS LGKPVKPS--GVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------L TVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD >Pan_troglodytes_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSLPSRQT------------AIIVNPPPPEYINTKKNGR-----LTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK LKLPDYYTIIKN--------PMDLNTIKKRLENKYYMKASECIEDFNTMFSN-CYLYNKPGDDIVLMAQALEKLFMQKLS QMPQEEQVVG---VKERIKKG---------------------------------------TQQNIAVSSAKEKSSSSATE KVFKQQEIP-------------------------------SVFSKTSISPLNVVQGASVNSGSQTAAQV----------- -------------------------------------------------------------------------------- -----------------------TKGVKR-KADTTTPATSAVKASSEFSPTFT--------------------------- --------------------EKS-VTLPPIKENM------PKNV----LPDSQQQ----------------YNVVKTVKV TEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY KYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKT------------------------DITETTGR------ ---ENTNEASSEGN------------------SSDDSEDERVKRLAKLQEQ----------------------------L KAVHQQLQVLSQVPFRKLNK-KKEKSKKEKKKEKVN-------------------------------------------- -------------------------------------------------------------------------------- -----NSNENPRKMCEQMRLKEKSKRNQ---------------------------------------------------- --------------------------------PKKRKQQFIGLKSED---------EDNAKPMNYDEKRQLSLNINKLPG DKLGRVVHIIQSREP-----SLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKP-----------PAKKIMMSK EELHSQKKQELEKRLLDVNNQLNSRKRQT----KSDKTQPS----------KAVENVSRLSE------------------ -------------------SSSSSS---------------SSS-ESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPS- KENVKKMKN-----ECILPE--------------GRTGITQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQEL EHLQTVK-NISPLQILPPSGE-----SEQLSNG----------------------------ITVMHPSGDS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------DTMMLESECQAPVQKDIKIKNADSWKS LGKPVKPS--GVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRGSGNG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------L TVEPFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD >Macaca_mulatta_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------PGDDIVLMAQALEKLFMQKLS QMPQEEQVVG---GKERIKKG---------------------------------------TQQNIAVFSAKEKSSPNATE KVFKQQAIP-------------------------------SVFPKTSVSPLNVAQGASVNSSSQTVAQV----------- -------------------------------------------------------------------------------- -----------------------TKGVKR-KADTTTPATSVVKASSEFSPTFT--------------------------- --------------------EKS-VTLPPIKENM------PKNV----LPDSQQQ----------------YNVVKSVKV TEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY KYNPPDHEVVTMARMLQDVFETHFSKIPVEPVESMPLCYIKT------------------------DITETTGR------ ---ENTNEASSEGN------------------SSGDSEDERVQRLAKLQEQ----------------------------L KAVHQQLQVLSQVPFRKLNK-KKEKSKKEKKKEKVN-------------------------------------------- -------------------------------------------------------------------------------- -----NSNENPRKMCEQMRLKEKSKRNQ---------------------------------------------------- --------------------------------PKKRKQQYIGQKSED---------EDNAKPMNYDEKRQLSLNINKLPG DKLGRVVHIIQSREP-----SLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKP-----------PAKKIMMSK EELHSQKKQELEKRLLDVNNQLNSRKRQT----KSEKTQPS----------KAVGSVSRLSE------------------ -------------------SSSSSS---------------SSS-ESESSSSDLSSSDSSGSESEMFPKFTEVKPNDSPS- KENVKKMKN-----ECILPE--------------GRIGITQIECSVQDRTSANTTLVHQTTPSHVMPPNHHQLAFNYQEL EHLQTVK-NISPLQILPPSGD-----SEQLSNG----------------------------ITVMHPSGDN--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------ATTMLESECQAPVQKDIKIKNADSWKS LGKSVKPS--GVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKEPKVSQENQRDLGNG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------L TVESFSNKIQNKCSGEEQKEHQQSLEAQDKSKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD >Mus_musculus_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSLPSRQ-------------TAIVNPPPPEYINTKKSGR-----LTNQLQFLQRVVLKALWKHGFSWPFQQPVDAVK LKLPDYYTIIKT--------PMDLNTIKKRLENKYYEKASECIEDFNTMFSN-CYLYNKTGDDIVVMAQALEKLFMQKLS QMPQEEQVVG---GKERIKKD---------------------------------------IQQKIAVSSAKEQIPSKAAE NVFKRQEIP-------------------------------SGLPDISLSPLNMAQEAPPICDSQSLVQI----------- -------------------------------------------------------------------------------- -----------------------TKGVKR-RADTTTPTTSIAKASSESPPTLR--------------------------- --------------------ETKPVNMP-VKENT------VKNV----LPDSQQQ----------------HKVLKTVKV TEQLKHCSEILKEMLAKKHLPYAWPFYNPVDADALGLHNYYDVVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCY KYNPPDHEVVAMARTLQDVFELHFAKIPDEPIESMHACHLTT------------------------NSAQALSR------ ---ESSSEASSGDA------------------SSEDSEDERVQHLAKLQEQ----------------------------L NAVHQQLQVLSQVPLRKLKK-KNEKSKRAPKRKKVN-------------------------------------------- -------------------------------------------------------------------------------- -----NRDENPRKKPKQMKQKEKAKINQ---------------------------------------------------- --------------------------------PKKKKP---LLKSEE---------EDNAKPMNYDEKRQLSLDINKLPG DKLGRIVHIIQSREP-----SLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKP-----------QAKKVVRSK EELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVEKPPPPPPPPPPPPPPPELASGSRLTD------------------ -------------------SSSSSGSGSGSSSSSSGSSSSSSSSGSASSSSDSSSSDSSDSEPEIFPKFTGVKQNDLPP- -----------------------------------KENIKQIQSSVQDITSAEAPLAQQSTAPCGAPGKHSQQMLGCQVT QHLQATE-NTASVQTQPLSGD-----CKRVLLG----------------------------PPVVH-TSAE--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------SLTVLEPECHAPAQKDIKIKNADSWKS LGKPVKAS--SVLKSSDELFNQFRKAAIEKEVKARTQEQMRKHLEHNAKDPKVSQENQREPGSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------L TLESLSSKVQDKSLEEDQSEQQPPSEAQDVSKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD >Canis_familiaris_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSLSSRQ-------------TAIVNPPPPEYLNTKKNGR-----LTNQLQYLQKIVLKALWKHSFSWPFQQPVDAVK LKLP-------------------------------------------------------PGDDIVLMAQALEKLFRQKLS QMPQEEQIVG---GKERVKKG---------------------------------------IQHNVTVPSVKEKQSPKALE KVFKQQVIP-------------------------------SVFPETSMSPSNMAQGTPLNSTSQTVAQV----------- -------------------------------------------------------------------------------- -----------------------TRGVKR-KADTTTPTAAVVKASGESSPTLT--------------------------- --------------------EQKSVKTPPLKENV------LKTV----FPDSQQQ----------------CKVVKNVKV TEQLRHCSEILKEMLAKKHLSYAWPFYNPVDVHALGLHNYYDIVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCY KYNPPDHEVVTMARMLQDVFEMHFAKIPDEPIESMPVCYIKT------------------------DTTKIPGR------ ---ESSSEASSEDN------------------SSGDSEDERVQRLTKLQEQ----------------------------L KAVHQQLQVLSQVPFHKLKK-KS-KSKREKKKEKIN-------------------------------------------- -------------------------------------------------------------------------------- -----SRDENPRKKFKQMKSKEKSKNNQ---------------------------------------------------- --------------------------------PKKRKQQVFTSKPED---------EDNAKPMNYDEKRQLSLDINKLPG DKLGRVVHIIQSREP-----SLRNSNPDEIEIDFETLKASTLRELEKYVAACLRKRPLKL-----------HGKKITKSK EEFHSQKKQELEKRLLDVNNQLNSRKCQT----KSEKTQSS----------KAVGSGSRLSE------------------ -------------------SSSSST---------------SSSSETESSSSDSSSSDSSDSESEMFPKFTGVKQNDSP-- KELVKKMKN-----MCSMKR--------------GKTQVVYSGKCGNDKTSAKTTLVCQTSYSCETPPNHHQSALNHQEL EHLQGVK-NISPLQIPPPSGD-----TEQHLNG----------------------------LTVTHQSDDN--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------DTRVLESECQVPVQKDIKIKNADSWKS LGKPVKTS--GVLKSSDELFNQFRKAAIEKEVKARTQELIRKHMEQNTKEPKRVQENQRDLG------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------F TQESFSNKMQNQYLGE-QKDHQQSSEAQDKYKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD >Felis_catus_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSLSSRQ-------------TAIVNPPPPEYINTKKNGR-----LTNQLQYLQKVVLKALWRHNFSWPFQQPVDAVK LKLPDYYTIIKT--------PMDLNTIKKRLEHKYYMKASECIEDFNIMFSN-CYLYNKPGDDIVLMAQALEKLFRQKLS QMPQEEQIIG---GKERIKKG---------------------------------------IQHNVAVPSGKEKQSPKALD KVFKQQVIP-------------------------------SVFPKTSISPSNVSQGTLFNTTSQTVAQV----------- -------------------------------------------------------------------------------- -----------------------TRGVKR-KADTTTPTTSVVKASGESSPTLA--------------------------- --------------------EKKSVKMPPMKENV------LKTV----LPDSQQL----------------CKVIKSVEV TEQLRHCSEILKEMLAKKHLSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCY KYNPPDHEVVTMARTLQDVFEMHFAKIPDEPVESMPVCYIKT------------------------DTTEVHDR------ ---ESRSEASSEDN------------------SSGDSEDERVQRLAKLQEQ----------------------------L KAVHQQLQVLSQVPFRKLKK-KN-KSKREKKKEKVN-------------------------------------------- -------------------------------------------------------------------------------- -----NRDENPRKKFKQMKLKEKSKSNQ---------------------------------------------------- --------------------------------PKKRKQQVLALKPED---------DANAKPMNYDEKRQLSLDINKLPG DKLGRVVHIIQSREP-----SLRNSNPDEIEIDFETLKASTLRELEKYVAACLRKRPLKP-----------HGKKIMKSR EEFHSQKKQELEKRLLEVNNRLNCRKRQP----KSEKTQSS----------KAVGSGSRLSE------------------ -------------------SSSSSSS----------SSSSSSSSETESSSSDSGSSDSSDSESEMFPKFTEAKQNDSP-- KEQVK------------------------------------IQSSVQDQASAKTTLFCQTSYSCETPADHHQLAFNHQEL EHLHSVK-NISSLQILPPSGD-----CEQHLNG----------------------------LTMMHQSGDN--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------DTTVLESEGPVPVQKDIKIKNAESWKS LGKPVKTS--GVLKSSDELFNQFRKAAIEKEVKARTQELIQKHVEQNTKETKVLQENQRDLG------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------C IQQSFQIKCKTSALEK--------------------SRKNISSLWKLKINTNSCFSKTVI---------------- >Monodelphis_domestica_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSLSSRQ-------------MAIVNPPPPEYINAKKNGR-----LTNQLQYLQKVVLKALWRHSFSWPFQQPVDAAK LKLPDYYSIIKK--------PMDLSTIKKRLEHKYYVKSSECVEDLKTMFTN-CYLYNKPGDDIVLMAQALEKLFMQKMS QMPSEEQVIG---GKERKRKG--------------------------------------TQPSSGVS-TIKEKPSPKASE MIVKQQMIPS------------------------------SVCPQTSLSPLHMAKAAPLSCTTQAVTQV----------- -------------------------------------------------------------------------------- -----------------------KRGVKR-KADTTTPTTSIVTASSESSPTLV--------------------------- --------------------EHKSAKIPLLKEKV------VKNI----VPDSQQQ----------------YKVVKSIKL TEQLKYCNEILKEMFAKKHLAYAWPFYKPVDVTALGLHNYYDVVKSPMDLGTIKKKMDNQEYKDAHEFAADVRLMFMNCY KYNPPDHEVVTMARTLQDVFEMQFAKIPDEPIERMPICYIKK------------------------DITKAYCR------ ---ESSSDASSEDN------------------SSEESPDERVQHLAKLQEQ----------------------------L KAVHQQLQVLSQVPYHKLKK-KNERSKREKRKEKKKFI------------------------------------------ -------------------------------------------------------------------------------- -----NKDESQRKNFKQIKLKKKLKSSQ---------------------------------------------------- --------------------------------PKKAKQQILTYKSED---------EDNAKPMNYDEKRQLSLDINKLPG DKLGRVVHIIESREP-----SLRNSNPDEIEIDFETLKASTLRELEKYVMACLRKRPRKF-----------HAKKIMKSK EELHSQKKQELEKRLLDVSNRLNSRKRQT----KSEKTQLP----------KAAGGATRLSE------------------ -------------------SSSSSGG-------------GSSSSGSGSSSSDSSSSDSSDSESETFPILTGIRQSGSPSK EKMKTLSSCRI---LNQDLLI-------------PKKLEEPQQLQILQSLPPAQISISPSLPEIISSVDVTSLWQNAPDM LTFEAFTPILSVSEQTSFSGDGKNECTSIVNAGKSTLLITTMWEGINSKTVKKEESASEQPVAAAFHQTAL--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------GLNVLEPELHLPTKKDIKIKNVDSWTN LGKTVTTS--VLSKSSDDLFRQFRKAAMEKEVKTRTQEQIRKQLGQDPKEPKTHPDKHRHFD------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---NNPNKIRNECYPEDQKPHPAPLEVQDPR---LIKDRNLARKKEQERRRREAMASTIDMNLQSDIMMTFEENLD >Ornithorhynchus_anatinus_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSLPSRQ--------------TIVNPPPPEYINTKKNGR-----ITNQLQYLQKVVIKAIWKHSFSWPFQQPVDAVK LRLPDYYRIIKN--------PMDLSTIKKRLEYKYYVKASECVEDFNTMFTN-CYLYNKPGDDIVLMAQALEKVFLQKVA QMPQEEEVIGR--SKEGKRKG--------------------------------------TEPSSTAAPTIKGKLPSKTSE TVGKQKVMT--------------------------------LCFQADDSPLQVVQAASQTSANQSVTQA----------- -------------------------------------------------------------------------------- -----------------------KKGVKR-KADTTTPTTSVVTESSESSPSFT--------------------------- --------------------EQKCAKMLPTKEKV------TKNV----LPDSQQL----------------CKTVKNIKL TEQLKHCNEILKELFSKKHLSYAWPFYKPVDVTALGLHNYYDVVKNPMDLGTIKKKMNNQNYKDAHEFAADVRLMFMNCY KYNPPDHEIVGMARTLQDVFEMQFAKIPDEPSDSVPLYYIK---------------------------TEALKR------ ---ESSSDASSEED------------------SSEDSEDERVQHLTKLQEQ----------------------------V RLGFCRMPFC--ISY----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Gallus_gallus_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSLPSLRR------------SLITNPPPPEYINNRNSGC-----QTNQLQYLQRVVMKAMWRHNFSWPFHQPVDAAA LNLPDYYSIIKK--------PMDLSTIKKRLEHNYYTKSAECIDDFKTMFLN-CYIYNKPGDDIVFMAQELEKVFMQKIA QMPPEE-ILIP--DKGKRKEKLSE-----------------------------------ETQHPNSGTSSKQSTRQKQAE S-GEQPTAIT------------------------------QELQKATLPPLSAAQLTALMPAAIPIAKT----------- -------------------------------------------------------------------------------- -----------------------KKGVKR-KADTTTPTTSILTTSSESSATCN--------------------------- --------------------KRKTVKACKGENECMIPKKILKKG----LPDSQQS----------------PRVLKKTQL SKQLKYCKEILKEMFSKKHSAYARPFLRSADVVSFSLGEKKGITKCPTDLGTIKKKMDNFEYRDIQEFATDVRLMFMNCY KRNSPDHEVVAMAKKLQDVFETHFAKIPDEPATSILLPQHTR------------------------EITKAYSS------ ---DSSSDDSSEEK------------------SSEDFEKERTVYLAKLQEQ----------------------------L KAVHQQLQALTRASLPRLKR-KKEKAKREKGENKEKAK------------------------------------------ -------------------------------------------------------------------------------- -----ASLIRKKKDLKHKKSKKKQSSNIQS-------------------------------------------------- --------------------------------KKTIQQVLLAHKSED---------DDGAKPMNYDEKRQLSLSINKLPG DKLGKVVHIIQSREP-----SLRNSSPDEIEIDFETLKASTLRELEKYVATCLRKRPRKQ-----------HAKKAMKSK QQLLSERKQELEKRLLDVNGQLNPKKENFKCNSAVESSAES-----------SIG-PSRLSE------------------ -------------------SSNGSSS------------SDSGSN----TSSASSSSDSSDSES----VMETCSEQNGIRQ NCLTSLEQPK----RMSYSAV-------------LQVQPSSITSSLQNHGSPEPQLLSPTVLQKLKPVQSRS----LKSA EQNAKSPSGIKHLPKSPLNMVIEQGGNKHLKN----------------------------LIEVKGRCSTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------NGTKTLETKSQSFPERAAGIKNIDSWVS LCKMMTLP--APIKSSAESFKHFRKVALQKAAGQAQEKERKYNEQSWHLSATSFREEEK-YDSP---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------S LHSFISSIN-TSLDCKPRKEENMSKQLPEAQQHPLVQDRNLARKMEQERRRREAMACTIDMNLQSDIMATFEENLE >Xenopus_tropicalis_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MSMSSRHLH-----------SSIVNPPPPEYINRKKTGR-----LTNQLQYLEKVVLKALWRHHFSWPFQQPVDAAK LNLPDYYQIIKN--------PMDLSTIRKRLEYNYYSKALDCIQDFNTMFTN-CYIYNKPGDDIVVMSQELEKVFMEKIA EMPHEEIELSV--VGNRGVKS--R-----------------------------------IKISAVAAEVCKKKMVSQKMH RRTFPCPVIA------------------------------MMPKRTTLVPLSVIRSSTSSHSASSVSKV----------- -------------------------------------------------------------------------------- -----------------------NKGIKR-KADTTTPAVSLIATSCESSPTLS--------------------------- --------------------EPKPNKILSGTEKTR-SAETSAVD----LPDSQHH----------------IHFIKSNQI CEQLKHCNNILNEMMSKKHAEYAWPFYK--TVIPTSLLDCSDAIKHPMDLATIRDKMENGLYKDTQDFASDVRLMFMNSY KYNPPDNEVVNMARKMQDVFEGMFAKIPDDPLATQS----MV------------------------ERYKTSTE------ ---ESSSSSSSEQS------------------SSSDSEDERAQHLALLQEQ----------------------------L RAVQEQLKALTETPIFSKIQPKSAVGVYDKYKQWVK-------------------------------------------- -------------------------------------------------------------------------------- ------CIEPMGKLLKRKKNYDAKKKKL---------------------------------------------------- ------------------------------------------HVSDE---------EEDVKPMSYDEKRQLSLDINKLPG EKLGRIVHIIQSREP-----SLKDSNPNEIEIDFETLKQSTLRHLEKYVMVCLRKRPKKP-----------SSIKSLKSK EQLNKEKKQELEKRLRDVSGQLSSAKKPK-----IQGFLYP---------MQSIGGPSRLSE------------------ -------------------SSTSSS------------------ASDVSNSSDSSSSDSSDSESATFPKNILAKKQTSTNY EVPLLLYYG-------CFVNK-------------PRTSIPQNGLCIGSQSLAYTTISTIVHPTPMALMPLHPGSTNYTSL QLLLKYG-LHVPLIIENPLGN-----SVLFENY----------------------------LEVLHPSQIE--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------QTFAIKEECLKPKYKNAKVKTSFCWEV FSKSLATTH-VTIKSSSNSFQQFRKAAIAKEERERALKAQELRRLEDSKAG-----MQEKLSPS---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------L PMETKVHEMQAQTIDEATKGEPTCNPVHEGITE---EERNLARMREQERRRREAMAGTIDMYLQSDIMATFEEHLC >Hydra_magnipapillata_BRDT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------MASNVLNFH HINNASNNKNTNLTFTGVDPANIKKPPLIIPSELSRPTNIQR-ITQKKAQVKAYPKNIKLEKLAVYSSCKAAVDACSCSG WKNPNPTKSIEQQQQQHGLWTTECRTCKHLLSDHVSHLQEETEEQMNFLMSMVVDIENLFMCVHKETDSDNKQVYFYLFK LLRKSIHQITKPTVEGPLGKPP---------------------------------------FENPNIEMAVKSFVAYKFT NENPVECQIMN-----------------------------ELARIFVRCLNHWKLETPTARKQRLETVSLLN-------- -----------------------------------------------------------------------NKVNILDN- ---------ELFESNTNADISSYKVDYTRWLCFSHVPLFCDSLQKYDVTSIFG--------------------------- -------------------KKFLRSVFCLMKQQLLDKFSAEKEK----LPADTRIK----------------VLEHFPRF LSLFEEEIKSEFSPIWNDDCSRINPIINPIETNTSSSQLFNDLTQTSIQINENTECKQNLLISSVEPSSTKAVTNPIKVE PVTSPSKVTSNISLIKSEKSSESIAPKETLTENKPDSKSSVTTLP------------------TETIASLAKAP------ TTITSITTASSKSITPLN--------------LPEVSSSEILKRKSNIVETP---------------------------V TKKMKLLSPIGDVPMEILARVIETITDPSKMVGPQGGFYP--------------------SQTARDEAAR---------- -------------------------------------------------------------------------------- ------SEERRGLIEFHVIGNSLTKKPSRQ------------------TTIWLIGLQN---------------------- --------------------------VFSYQLPRMPKEYITRLVFDP---------KHRTLALIKDGRPIGGVCFRMFPT QNFTEIVFCAVSSNEQVKG-YGTHMMNHLKDYHTQNGILNFLTYADEYAIGYFKKQGFSKDIKLAKCEYTGYIKEYEGAT LMHCSLNPKIPYREFSLVIKKQKEIVRQLIKEKQEEIKKVYPG------LTCFKNGVSEIPIS----------------- -------------------SIPGIEETG--------------WKQIQKNGKDILLNATAHHGALLNVLNAVKNHASAWPF LKPVPRNEVP--------------------------DYYDIIKYPMDLQTMEERLEKKYYTLKKLFVADMSRIFSNCRTY NGPDTEYYKCAGVVERYFLTKLKEYYDDSTTIEIKEEDVS---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Homo_sapiens_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIR KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSVTSAHQVPAVS SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP----------- ------------------------------------------------------------------------LLAVTAAP ----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP----------------------------- ---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------MPPGLAKSS------ SE-SSSEESSSESSSEEEEEEDEE-DEEEEESESSDSEEERAHRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGAD--------- -------------------------------------------------------------------------------- ------EDDKGPRAPRPPQPKKS-KKAS-------------------GSGGG-SAALGPSGFGPS-GGSGTKLQAGVQWR DLGLLQPPLLGFKRFSCLSLPSSQDYRLPKKATKTAPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-NEKTESS----------SAQQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Pan_troglodytes_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIR KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSVTSAHQVPAVS SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP----------- ------------------------------------------------------------------------LLAVTAAP ----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP----------------------------- ---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------MPPGLAKSS------ SE-SSSEESSSESSSEEEEEEDE--DEEEEDSESSDSEEERAHRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGAE--------- -------------------------------------------------------------------------------- ------EDDKGPRAPRPPQPKKS-KKAS-------------------GSGGG-SAALGPSGFGPS-GGSGT--------- --------------------------KLPKKATKTAPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-NEKTESS----------SAQQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Macaca_mulatta_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIR KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSVTSAHQVPAVS SVSHAALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP----------- ------------------------------------------------------------------------LLAVTAAP ----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP----------------------------- ---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------MPPGLAKSS------ SE-SSSEESSSESSSEEEEEEDEDDEEEEEESESSDSEEERAHRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGAD--------- -------------------------------------------------------------------------------- ------EDDKGPRAPRPPQPKKS-KKAS-------------------GSGGG-SAALGPSGFGPS-GGSGTKLGTGVQWH HLGSWQPPLLGIKRFCLSLPNSWDYRLAPPSPANFSPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK EELALEKKRELEKRLQDVSGQLNSTKKPPKKV-NEKTESS----------SAQQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Mus_musculus_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MLQNVTPH-KLPGEGNAGLLGLGPEAAAPGKRIR KPSLLYEGFESPTMASVPALQLAPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSITSAHQVPAVS SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP----------- ------------------------------------------------------------------------LLAVSAAP ----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP----------------------------- ---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLTKSS------ SE-SSSEESSSESSSEEEEEEEE--DEDEEESESSDSEEERAHRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRIGID--------- -------------------------------------------------------------------------------- ------EDDKGPRAPRPPQPKKS-KKAG-------------------GGGSN-ATTLSHPGFGTS-GGSSN--------- --------------------------KLPKKSQKTAPPVL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIRKPVGKTK EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKTESS-----------AQQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Rattus_norvegicus_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MLQNVTPH-KLPGEGNAGLLGLGPEAAAPGKRIR KPSLLYEGFESPTMASVPALQLAPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSITSAHQVPAVS SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP----------- ------------------------------------------------------------------------LLAVSAAP ----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP----------------------------- ---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLAKSS------ SE-SSSEESSSESSSEEEEEEDE--EDEEEESESSDSEEERAHRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRIGID--------- -------------------------------------------------------------------------------- ------EDDKGPRAPRPLQPKKS-KKAG-------------------GGGSN-ATTLSHPGFGTS-AGSSN--------- --------------------------KLPKKAQKTAPPVL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIRKPVGKTK EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKTESS-----------AQQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Canis_familiaris_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MLQNVTPHSKLPGEGNAGLLGLGPEAAAPGKRIR KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSITSAHQVPAVS SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPQ----------- ------------------------------------------------------------------------LLAVSAAP ----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP----------------------------- ---------------PGS-LEAKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLAKSS------ SE-SSSEESSSESSSEEDEEEDEEEEEEEEESESSDSEEERAHRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGVD--------- -------------------------------------------------------------------------------- ------EDDKGSRAPRPSQPKKS-KKAS-------------------GSGGGSAATLGPPGFGPS-GGSGT--------- --------------------------KLPKKATKTAPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKTESS----------STQQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Felis_catus_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSITSAHQVPAVS SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP----------- ------------------------------------------------------------------------LLAVSAAP ----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP----------------------------- ---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLAKSS------ SE-SSSEESSSESSSEEEEEEDEEDEEEEEESESSDSEEERAHRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGVD--------- -------------------------------------------------------------------------------- ------EEDKGTRAPRPSQPKKS-KKAS-------------------GSGGGSAATLGPPGFGPS-GGSGT--------- --------------------------KLPKKATKTAPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKTESSS---------SAQQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Loxodonta_africana_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MLQNVTPHNKLSGEGNAGLLGLGPEAAAPGKRIR KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAAFQGSITSAHQVPAVS SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP----------- ------------------------------------------------------------------------LLAVSAAP ----------------SAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP----------------------------- ---------------PGA-LEPKAARLPPVRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLAKSS------ SE-SSSEESSSESSCE-----------------SSDSEEERAHRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKS--------------------------EKHRGRAGVD--------- -------------------------------------------------------------------------------- ------EDDKGPRASRPPQPKKS-KKAS-------------------GSGSA--AALGPPGFGPS-GGT----------- --------------------------KLPKKATKTAPPAL-PAGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK EELALEKKRELEKRLQDVSGQLNSTKKPPKKT-SEKTESS----------VAQQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Monodelphis_domestica_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MLQNVTPHSKLPGEGNAGLLGLGPEAAAPGKRIR KPSLLYEGFESPTMASVPALHLPPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWLASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA LMPSEEQELVVTIPKNSHKKGA---------------------------------------KLAALQSSLTNAHQVPAVS SLSHTPLYSPSP----------------------------EIPTTVLNIPHGSVISSPLLKSLHSAGTP----------- ------------------------------------------------------------------------LLAVSAAP ----------------TAQPLTKKKGVKR-KADTTTPTPTAILAPGSPASP----------------------------- ---------------PGGGPEPKAARLPPTRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPASTV-----------------------LPPGLAKSS------ SE-SSSEESSSESSSEEEEEEEE--EEEEEETESSDSEEERANRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGMD--------- -------------------------------------------------------------------------------- ------EDDKGPRLPRPPPPKKSSKKSG-------------------GGGGSGPGAAGPPGFGLP-GSGAT--------- --------------------------RPPKKAMKTAPPPP-AAAYDS-------EEEEESRPMSYDEKRQLSLDINKLPG EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKVESA------------QQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Gallus_gallus_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MASVPALQTPQAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWGAAECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA QMPPEEQEIVVPVAKNSHKKGA---------------------------------------SRAAG---LTAAQQVPAVS SVSHTAVYTPSP----------------------------DIATTIVNIPHPSVISAPLLKSLHSTAP------------ -------------------------------------------------------------------------AVLTAPA ----------------PTQPVAKKKGVKR-KADTTTPTTTAIIATSGESSP----------------------------- ---------------SATLLEAKAAKIP-ARRESGRPIKPPK----KDLPDSQQ-----------------HQTSKKGKL SEQLKYCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHEIIKHPMDLSTIKRKMENRDYHDAQEFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFSYAKMPDEPQDASPPSVSAP-----------------------LLGALSKSS------ SEESSSDEDDEDEDDEDDDEDESSSESSSESEESSDSEEERANRLAELQEQ----------------------------L RAVHEQLAALSQGPVSK--PKKKREK---KKKKKS--------------------------EKHKGRGGDE--------- -------------------------------------------------------------------------------- ------ES-----RARQAQLRKA-KKGG-------------------GGGSG--------------GGSSK--------- ---------------------------NSKKAAKAALPPP-PALYDS-------EEEEESKPMTYDEKRQLSLDINKLPG EKLGRVVHIIQSREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYS-------ETMKKPVGKTK EELALEKKRELEKRLQDVSGQLNSAKKPPKKA-NEKPESA------------QQVAVSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Xenopus_tropicalis_BRD2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MHLKDISISCRPPLDLNHGMMGQSIEG-TPGKRIR KPSLLYEDFEGPNMTSSVFHQLPQTN--PPPPEFSNSKKPGR-----STNQLQYLHKVVMKSLWKHQFSWPFRQPVDAVK LGLPDYHKIIKQ--------PMDMGTIKKRLENNYYWSALECMQDFNTMFTN-CYIYNKPTDDIVLMAQSLEKMFLQKVA QMPQEEQEIPNTASKIKNVKIS---------------------------------------KTSGPTGGVTTAHQVPAVS --SQSSLYPSSP----------------------------EVPTTMLSLAHSSIISNPVLKSMPSSQAV----------- ------------------------------------------------------------------------LSVLPGAT ------------------QPVAKKKGVKR-KADTTTPTTTAIIATSGDLSP----------------------------- ---------------LQA-SETKPAKIP-ARRESGRPIKPPK----KDLPDSQQ-----------------HQTSKKGKL SEQLKYCNGILKELLSKKHAAYAWPFYKPVDVSALGLHDYYDIIKHPMDLSTIKKKMDNREFKDAQEFAAAVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLVVNPPSTSSQ-----------------------LPPSDSKSS------ SE--SSSESSSESSDDSE--------------SSDDSEEERANRLAELQEQ----------------------------L RAVHEQLAALSQGPISK--HDEWRSSKSKPSQAKK--------------------------SSKKSG---G--------- -------------------------------------------------------------------------------- ------GIATSSTQPAPKLTRHAYSKSSFLCR-------------LRGTQETDGVKLHPPGGRTFRKRMKS--------- ----------------------------TKKTFKSVPPAP-SVLYDS-------EEEEESKPMTYDEKRQLSLDINKLPG EKLGRVVHIIQSREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVMSCLRKKPRKPYT---------LKKPVGKTK EEIALEKKRELEKRLQDVSGQLNSAKKPPKKS-HDKAESA------------QQVSVTRL-------------------- -------------------SASSSSS-----------------DSDSSSSSTSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Takifugu_rubripes_BRD2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------GLLGVS--AMDQGSATAGKRIR KPSLLYEGFESPGMP--PVNQMTHPG--PPQPPVKDPSRQGR-----MTNQLQFLQKVLLKSLWRHHFAWPFHEPVDAVK LNLPDYHKIIKT--------PMDMGTIKKRLENNYYRSASECMQDFNTMFTN-CYIYNKPTDDIVLMAQSLEKAFLQKVA QMPQDELELPPPPPRMKSGKPG---------------------------------------KKGRVSGGVTTAHQVPAVS ---QSVYSPPTP----------------------------DTPDSILPTPPQTHLLKSLPHSF-STAQT----------- ------------------------------------------------------------------------APTITGLP ----------------PTQPTAKKKGVKR-KADTTTPTTVAMPIMNTMGVS---MGS----------------------- -------------------MMSSKASVGERRGVSGRPIKPPK----KDLPDSMLP----------------PPVR-RSKL SPQLRYCNGVLKELLSKKHAGYAWPFYKPVDASSLGLHDYHDIIKQPMDLSTIKRKMDNREYLDSQQFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFCFAKMPDEPPAPPSSSSSSS-----------------------SSSSSSSES------ DLSSESEDSESS--------------------PSSDSEEERANRLAELQEQ----------------------------L KAVHEQLTALSQGPIIKPKKKKEKKDKKKKKKVEK--------------------------EKHRRIEDQ---------- -------------------------------------------------------------------------------- --------------PKPPKITKAPKSKST-----------------RAAGCPVLPIKKAPSKKNSKSNIGTTEWSI---- -FAFERAFLKMNKQFLSFSSPRSKKTGMMFSMPQTVHDPM-VSHFDS-------DEEE-TAPMSYDEKRQLSLDINKLPG EKLGRVVYIIQSREP-----SLRDTNPEEIEIDFETLKPSTLRELERYVMTCLRKKPRKPY---------ASKNMAGKSR EELALEKQLELERRLMDVSGQLNSGKKPPKTK---PEKP-A---------AEPHTQPSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Tetraodon_nigroviridis_BRD2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------QVGVEGGLMGVS--TMDQGSATAGKRIR KPSLLYEGFESPGMP--PVNQMSHPG--PPQPPVKDPSRQGR-----MTNQLQFLQKVLLKSLWRHHFAWPFHEPVDAVK LNLPDYHKIIKT--------PMDMGTIKKRLENNYYRSASECMQDFNTMFTN-CYIYNKPTDDIVLMAQSLEKAFLQKVA QMPQDELELPPPPPRMKTGKPG---------------------------------------KKGRVSGGVTTAHQVPAVS ---QSVYSPPTP----------------------------ETPDSLLSTPPQTHLMKSLPHSF-SAAPT----------- ------------------------------------------------------------------------TPTMTGLP ----------------PTQPTAKKKGVKR-KADTTTPTTVAMPIMNTMGVS---MGMGGGHGSPLTLTSLGVDHNSSLGM SQGLAPGMGLSMGMGCGAGMMSTKASVGERRGVSGRPIKPPK----KDLPDSMLP----------------PPVR-RSKL SPQLRYCNGVLKELLSKKHAGYAWPFYKPVDASSLGLHDYHDIIKQPMDLSTIKRKMDNREYLDSQQFAADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFCFAKMPDEPPAPP------------------------------------TES------ DLSSESEDSESS--------------------PSSDSEEERANRLAELQEQ----------------------------L KAVHEQLTALSQGPIIK---------------LEK--------------------------EKHRRIEDQ---------- -------------------------------------------------------------------------------- --------------PKPPKIAKAPKSKST-----------------RAAGCPVLPMKKAPSKKNSKNNL----------- ----------------FLSSSRSKKSGMMFSMPQTVHDPM-VSHFDS-------DEEE-TAPMSYDEKRQLSLDINKLPG EKLGRVVYIIQSREP-----SLRDTNPEEIEIDFETLKPSTLRELERYVMTCLRKKPRKPY---------ASKNMAGKSR EELALEKQLELERRLMDVSGQLNSGKKPPKTK---PEKP-A---------AEPHTQPSRL-------------------- -------------------SASTSDS-----------------DS----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------- >Oryzias_latipes_BRD2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------SHTGYEIGHTGV---MMDQS--AAGKRIR KPSLLYEDFESPGMP--AISQMAPSG--PPQPPVRDPSRHGR-----MTNQLQFLQKVVLKSLWRHHFAWPFHEPVDAAK LNLPDYHKIIKT--------PMDMGTIRKRLENNYYRSASECMQDFNAMFTN-CYIYNKPTDDIVLMAQSLEKAFLQKVA QMPQEEIELPPPVPRSKQSK---------------------------------------------ISGGVTTAHQVPAVS ---QSVYSPPTP----------------------------ETPDSILSTPPQTILTKCSSITL-QPEQT----------- ------------------------------------------------------------------------IPAITGPP ----------------PTQPTAKKKGVKR-KADTTTPTTMAMPIMSTLGVTGIGLGMVGGHDSPLTLTSLGMDHSSSLGM NQAISISQGMGMGMGGGTMMLGAKATSGSRRGVSGRPIKPPK----KDLPDSILP----------------TPVR-RSKL SPQLRYCSGVLKELLSKKHAAYAWPFYKPVDAVSLGLHDYHEIIKFPMDLSTIKRKMDGREYREAQQFSADVRLMFSNCY KYNPPDHDVVAMARKLQDVFEFCFAKMPDEAPAPPSSTSSSS-----------------------SSSSS-SES------ ELSSDGEESESS--------------------PSSDSEEERANRLAELQEQ----------------------------L KAVHEQLTALSQGPIVKPKKKKEKKDKKKKKRVEK--------------------------ERHRRIEDDL--------- -------------------------------------------------------------------------------- ---------TPIRPPKAPKMTKTSKTKR--------------------MDCPVIPMKKTQSKKNSKSKS----------- -----------------------KKAAITFNMP--HHDPL-VGHFDS-------DEEEDTAPMSYDEKRQLSLDINKLPG EKLGRVVYIIQSREP-----SLRDTNPEEIEIDFETLKPSTLRELERYVMTCLRKKPRKPY--------VSTKNSAGKSR EELALEKQMELERRLMDVSGQLNSGKKPAKNK---PDKP-A---------SDVHTQPSRL-------------------- -------------------SASSSSS-----------------DS-SSSSSSSSSSDTSESDSG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------