>Homo_sapiens_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------MHPEGGQFVPQLLGHLLATKLKRFLLSKGG--RRAQIPDVS-RATPHTI DEMPEAAVKS----TANKYQVFFFGTHETAFLG--PKDLFPYE---ESKEKFGKPNKR--KGFSEGLWEIENNPTVKASG YQ-----------------------------------------------------SSQKKS-CVEEPEPEPE--AAEG-- -------------------------------------------------------------------------------- -------------------------------------------DGDKKGNAEGSSDE--EGKLVIDEPAKEKNEK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GALKRRAGDLLEDS---------------------PKR PKEAENPEGE--------------------------EKEAATLEVERPLPMEVEKNSTPSEPGSG--------------- ------------------------------------------------------RGPPQEEE-----EEEDEEEEATKED AE--------APG-IRDHESL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Pan_troglodytes_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------MHPEGGQFVPQLLGHLLATKLKRFLLSKGG--RRAQIPDVS-RATPHTI DEMPEAAVKS----TANKYQVFFFGTHETAFLG--PKDLFPYE---ESKEKFGKPNKR--KGFSEGLWEIENNPTVKASG YQ-----------------------------------------------------SSQKKS-CVEEPEPEPE--AAEG-- -------------------------------------------------------------------------------- -------------------------------------------DGDKKGNAEGSSDE--EGKLVIDEPAKEKNEK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GALKRRAGDLLEDS---------------------PKR PKEAENPEGE--------------------------EKEAATLEGERPLPMEVEKNSTPSEPGSG--------------- ------------------------------------------------------RGPPQEEE-----EEEDEEEEATKED AE--------APG-IRDHESL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Callithrix_jacchus_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------MHPKGGQFVPQLLGHVLATKLKPFLLSKGR--RRAQILDVS-GATPHTI DEMPEAAVKS----TANKYQVFFFGTHETAFLG--PKDLFPYE---ESKEKFGKPNKR--KGFSEGLWEIENNPTVKASG YQ-----------------------------------------------------SSQKKS-CVEEPEPEPE--ATEG-- -------------------------------------------------------------------------------- -------------------------------------------DSDKKGNAEGSSDE--EGKLVIDEPAKEKNEK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GALKRRAGDLLEDS---------------------PKR PKEAENPEEE--------------------------EKEAATLEGERPLPVEVEKNSTPSEPGSG--------------- ------------------------------------------------------RGPPQEEE-----EEEEEEEEAAKED AE--------VPA-IRDHESL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Mus_musculus_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MSRSNRQKEYKCGDLVFAKMKGYP--HWPARI DEMPEAAVKS----TANKYQVFFFGTHETAFLG--PKDLFPYE---ESKEKFGKPNKR--KGFSEGLWEIENNPTVKASG YQ-----------------------------------------------------SSQKKS-CAAEPEVEPE--AHEG-- -------------------------------------------------------------------------------- -------------------------------------------DGDKKGSAEGSSDE--EGKLVIDEPAKEKNEK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GTLKRRAGDVLEDS---------------------PKR PKESGDHEEE--------------------------DKEIAALEGERPLPVEVEKNSTPSEPDSG--------------- ------------------------------------------------------QGPPAEEE-----EGE---EEAAKEE AE--------AQG-VRDHESL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Rattus_norvegicus_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MSRSNRQKEYKCGDLVFAKMKGYP--HWPARI DEMPEAAVKS----TANKYQVFFFGTHETAFLG--PKDLFPYE---ESKEKFGKPNKR--KGFSEGLWEIENNPTVKASG YQ-----------------------------------------------------SSQKKS-CAEEPEVEPE--AHEG-- -------------------------------------------------------------------------------- -------------------------------------------DGDKKGNAEGSSDE--EGKLVIDEPAKEKNEK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GMLKRRAGDMLEDS---------------------PKR PKEPGDHEEE--------------------------EKEIAALEGERPLPVEMEKNSTPSEPDSG--------------- ------------------------------------------------------QGPPPEEE-----EGE---EAAAKEE AE--------AQG-VRDHESL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Felis_catus_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------QHPERGRFVPQALGHLPASKLEPRPSAGRG--PRCQTPGSG-VGVGGGI DEMPEAAVKS----TANKYQVFFFGTHETAFLG--PKDLFPYE---ESKEKFGKPNKR--KGFSEGLWEIENNPTVKASG YQ-----------------------------------------------------SAPKKS-SVDEPEPEPE--ATEG-- -------------------------------------------------------------------------------- -------------------------------------------DGDKKGSAEGSSDE--EGKLVIDEPAKEKNEK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GALKRRAGDLLEDS---------------------PKR PKETEDPEGE--------------------------EKEVAPLEAERPLPVEVEKNRTPSEPGSG--------------- ------------------------------------------------------RGLPQEED------EELEEEEAAKED SE--------APG-IRDRERV----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Equus_caballus_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------I DEMPEAAVKS----TANKYQVFFFGTHETAFLG--PKDLFPYE---ESKEKFGKPNKR--KGFSEGLWEIENNPTVKASG YQ-----------------------------------------------------SSQKKS-SVEEPEPEPE--ATEG-- -------------------------------------------------------------------------------- -------------------------------------------DGDKKGNAEGSSDE--EGKLVIDEPTKEKNEK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GALKRRAGDLLEDS---------------------PKR PKEAEDPEGE--------------------------EKEAATLESERPLPVEVEKNSTRSEPGSG--------------- ------------------------------------------------------RGPPQEEE-----EEE-EEEEAAKED AE--------APG-IRDHESL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Gallus_gallus_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MSRSHRQKEYKCGDLVFAKMKGYP--HWPARI DEMPEAAVKS----SSNKYQVFFFGTHETAFLG--PKDLFPYE---ECKEKFGKPNKR--KGFSEGLWEIEHNPTVKASG Y-Q----------------------------------------------------PTQKKT-CPEDAEPEQE---PEG-- -------------------------------------------------------------------------------- -------------------------------------------DGEKKGNAEGSSDE--EGKLVIDEQSKEKNEKA---- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------GIKRKAEDVLEDS---------------------PKR TKEMEGQE---------------------------AEKKTDNEEAPKEEP---KPNPAEEEKEKN--------------- ------------------------------------------------------SDAASVPDAN-EAKQEGKDK------ ----------AEEVRDHKESL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Taeniopygia_guttata_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------I DEMPEAAVKS----SSNKYQVFFFGTHETAFLG--PKDLFPYE---ECKEKFGKPNKR--KGFSEGLWEIENNPTVKASG Y-Q----------------------------------------------------PTQKKS-CPTAA--ERE---AEG-- -------------------------------------------------------------------------------- -------------------------------------------DGEKKGNAEGSSDE--EGKLVIDEQSKEKNEKG---- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------GTKRKAEDALEDS---------------------PKR PKDAEGQE---------------------------GDKKVDNEEAPKE-----EPKGNP--GE----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Xenopus_tropicalis_HDGF -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MSRSNRQREYKCGDLVFAKMKGYP--HWPARV DEVPEPNAKS----SANKYQVFFFGTHETAYLG--SKDIFPYE---ETKEKYGKTNKR--KGFSEGLWEIENNPTVKSSG HQPSRKRSSTT-------------------------------KAGRGGGAKNSGKAARKKNLEEDEDADADAEEKEEA-- -------------------------------------------------------------------------------- -------------------------------------------DSEKKGNAEGSSDE--EGKLVIDEQSKEKSDK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------TANKRKAEDTAESS---------------------PKK AKVEDDKEPEKN-----------------------EKEESNEEERVQTPEAGKEKNREPPKPAED--------------- ------------------------------------------------------SGKEKVEE-----------KPAVGEE TK-------------EQKESL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Takifugu_rubripes_HDGF_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MPRSNRQREYKPGDLVFAKMKGYP--HWPARI DELPEGAVKS----PSNKYQVFFFGTHETALLG--ANDLFPYD---EHKEKFGKAKKR--KGFAEGLWEIENNPTVTHEA YEPFGD------------------------QFSNLIMFENDSGIEILITATRSSIVMSKKDDASEG--------AGEA-- -------------------------------------------------------------------------------- -------------------------------------------GSPEKADAEGSSDED-EGALVIDEKSEK--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GGNKRKVEEPTEVS---------------------PKR LKDSEGEGDS----------------------------KVD--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Tetraodon_nigroviridis_HDGF_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MPRSNRQREYKPGDLVFAKMKGYP--HWPARI DELPEGAVKS----PSNKYQVFFFGTHETALLG--ANDLFPYD---EHKEKFGKAKKR--KGFAEGLWEIENNPTVTHEG YE------------------------------------------------------SSKKDDASEG--------AGDA-- -------------------------------------------------------------------------------- -------------------------------------------GSPEKADAERSSDED-EGALVIDEKSEK--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GGNKRKAEESTEVS---------------------PKR LKDSEGEGDS----------------------------KVDGNKSNA----EAKLNDVAG-------------------- ----------------------------------------------------------ADLKA------EAQEKAPDGGQ LT--------AEK------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Homo_sapiens_HDGFL1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------MSAYGMPMYKSGDLVFAKLKGYA--HWPARI EHMTQP----------NRYQVFFFGTHETAFLS--PKRLFPYK---ECKEKFGKPNKR--RGFSAGLWEIENNPTVQASD CP-----------------------------------------------------LASEKG-SGDGP--WPEPEAAEG-- -------------------------------------------------------------------------------- -------------------------------------------DEDKPTHAGGGGDE--LGKPDDDKPTEEEK------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GPLKRSAGDPPEDA---------------------PKR PKEAAPDQEEEA-----------EAERAAEAERAAAAAAATAVDEESPFLVAVENGSAPSEPGLV--------------- ------------------------------------------------------CEPPQPEEEELREEEVADEEASQEWH AE--------APG-GGDRDSL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Pan_troglodytes_HDGFL1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------MSDYSMPTYKSGDLVFAKLKGYA--HWPARI EDMTQP----------NRYQVFFFGTHETAFLS--PKRLFPYK---ECKEKFGKPNKR--RGFSEGLWEIENNPTVQASD CP-----------------------------------------------------LASEKG-SGDGP--WPEPEAAEG-- -------------------------------------------------------------------------------- -------------------------------------------DEDKPTHAGGGGDE--LGKPDDDKPTEEEK------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GPLKRSAGDPPEDA---------------------PKR PKKAAPDQEEKE-----------EAEAERAAA--AMAAAAAAVDEECPFLVAVENGSAPSEPGLA--------------- ------------------------------------------------------CEPPQPEEEELREEEVADEEASQEWH AE--------APG-GGDRDSL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Macaca_mulatta_HDGFL1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------MSAYGMPMYKSGDLVFAKLKGYA--HWPARI EHMTQP----------NRYQVFFFGTHETAFLS--PKRLFPYK---ECKEKFGKPNKR--RGFSEGLWEIENNPTVQAAD CP-----------------------------------------------------LALEKG-GGDGP--RPEPEAAEG-- -------------------------------------------------------------------------------- -------------------------------------------DADKPTHADGGGDD--VGKPHDDKPAEEKEEK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GPLKRSAGDPPEDA---------------------PKR PKEAAPDQEEKE-----------EKEE------AEAAAAAATFDEESPLLVAVENGSAPSEPGLA--------------- ------------------------------------------------------CEPPQPEEEELREEEVAEEEASQEWH AE--------APG-GGDRDSV----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Bos_taurus_HDGFL1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------MSRFYRRKYKCGDLVFAKLKGYA--HWPARI EQTAEA----------NRYQVFFFGTHETAFLG--PRHLFPYE---ESKEKFGKPNKR--RGFSEGLWEIENNPTVQASD YQ-----------------------------------------------------CALEKS-CPEE----PEPEVAEG-- -------------------------------------------------------------------------------- -------------------------------------------GEDPKSHTNGGDDDD-QGKLGVDLPAEEENEK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ETLKRTAEDPPEDI---------------------PKR PKEADP--EEGE-----------ERKE--------AAAVAEEAEDARPLLVEVENDPAASVLGLA--------------- ------------------------------------------------------WGLPVMEQE--------PEEESAERE AQ--------APGVGGGHESQ----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Loxodonta_africana_HDGFL1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MSLHNRRK-YKRGDLVFAKLKGFM--HWPARI EQTYES----------NKYQVFFFGTHETAFLG--PKNLFPYE---ESKEKFGKPNKR--RGFSEGLWEIENNPTVKASD CH-----------------------------------------------------LSQEKS-CRTEPHHKKT--TTEG-- -------------------------------------------------------------------------------- -------------------------------------------DGDKKRTNEGGGHK--EGKPALDEPTKE--EK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------AALKRGAGDLLEYS---------------------PKR PKEAELKREE---------------------------KEEVRIDGERPLLVEAENSSTPSEPNSV--------------- ------------------------------------------------------CNPPQEKR------EPEEVEEAPKKE AE--------APE-ARDQESL----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Homo_sapiens_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MPHAFKPGDLVFAKMKGYP--HWPARI DDIADGAVKP----PPNKYPIFFFGTHETAFLG--PKDLFPYD---KCKDKYGKPNKR--KGFNEGLWEIQNNPHASYSA P---------------------PPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNS G--LKRKTPALKMSVS-KRARKASSDLDQA-SVSPSEEENSES------------------------------------- -----------------------------------------SSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPS- ----ASDSDSKADSDG----AKPEPVAMARSASSS---SSSSSSSDSDVSV-----KKPPRGRK-PAEKPLPKPRGRKPK PERPPSSSSSDSDSD----EVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKE---RRRERADRGEAE-RG SGGSSGDELREDDEPVKK-RGRKGRGRGPPSSSDSE-------------------------------------------- -------------PEAELEREAKKSAKKPQ--SSSTEPARKPGQKEKRVRPEEKQQAKPVK--VERTRKRSEGFSMDRKV EKKK---EPSVEEK---LQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVME KAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDK EHEEGRDSEEGPRCGSSEDLH--DSVREGPDLDRPGSDRQERERARGDSEALDEES------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Pan_troglodytes_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MPHAFKPGDLVFAKMKGYP--HWPARI DDIADGAVKP----PPNKYPIFFFGTHETAFLG--PKDLFPYD---KCKDKYGKPNKR--KGFNEGLWEIQNNPHASYSA P---------------------PPVSSSDSEAPEANPAGGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNS G--LKRKTPALKMSVL-KRARKASSDLDQA-SVSPSEEENSES------------------------------------- -----------------------------------------SCESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKK----- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------AKKSAKKLQ--SSSTEPARKPGQKEKRARPEEKQQAKPVK--VERTRKRSEGFSMDRKV EKKK---EPSVEEK---LQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVME KAAEVYTRLKSRVLGPKIEAVQKANKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESTEDK EHEEGRDSEEGPRCGSSEDLH--DSIREGPDLDRPGSDRQERERARGDSEALDEES------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Gorilla_gorilla_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- P---------------------QPVSSSDSEAPEANPAGGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNS G--LKRKTPALKMSVS-KRARKASSDLDQA-SVSPSEEENSES------------------------------------- -----------------------------------------SSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPS- ----ASDSDSKADSDG----AKPEPVAMARSASSS---SSSSSSSDSDVSV-----KKPPRGRK-PAEKPPPKPRGRKPK PERPPSSSSSDSDSD----EVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKE---RRRERADRGEAE-RG SGGSSGDEFREDDEPVKK-RGRKGRGRGPPSSSDSE-------------------------------------------- -------------PEAELEREAKKSAKKLQ--SSSTEPARKPGQKEKRARPEEKQQAKPVK--VERTRKRSEGFSMDRKV EKKK---EPSVEEK---LQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVME KAAEVYTRLKSRVLGPKIEAVQKANKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATLQKGESAEDK EHEEGRDSEEGPRCGSSEDLH--DSVREGPDLDRPGSDRQECERARGDSEALDEDS------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Mus_musculus_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MPHAFKPGDLVFAKMKGYP--HWPARI DDIADGAVKP----PPNKYPIFFFGTHETAFLG--PKDLFPYD---KCKDKYGKPNKR--KGFNEGLWEIQNNPHASYSA P---------------------PPVSSSDSEAPEADLGCGSDVDKDKESRRVMTVTAVTTTATSDRMESDSDSDKSSDHS G--LKRKTPVLKVSVS-KRARRASSDLDQA-SVSPSEED-SES------------------------------------- -----------------------------------------PSESEKTSDQDFTPEKKTAARPPRRGPLGGRKKKKVPS- ----ASDSDSKADSDG----AKEEPVVTAQPSPSSSSSSSSSSSSDSDVSV-----KKPPRGRK-PAEKPPPKPRGRRPK PERPPSTSSSDSDSDSG--EVDRISEWKRRDEERRRELEARRRREQEEELRRLREQEREEKE---RRKERAERG------ --GSSGEELEDE-EPVKK-RSRKARGRGTPSSSDSE-------------------------------------------- -------------PEGELGKEGKKLAKKSQ--LPGSESARKPGQKEKRGRPDEKPRARPVK--VERTRKRSEGLSLERKG EKKK---EPSVEER---LQKLHSEIKFALKVDNPDVRKCLSALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMA KAAEVYTRLKSRVLGPKVEALQKVNKAGAEKERADNEKLE-EQPGEQAPRELAEDEPSTDRSAPVNGEATSQKGENMEDR AQEDGQDSEDGPRGGSSEELH--DSPRDNSDPAKPGNERQDHERTRLASESANDDNEDS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Rattus_norvegicus_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MPHAFKPGDLVFAKMKGYP--HWPARI DDIADGAVKP----PPNKYPIFFFGTHETAFLG--PKDLFPYD---KCKDKYGKPNKR--KGFNEGLWEIQNNPHASYSA P---------------------LPVSSSDSEAPEADLGGGSDADKEKEARRVMTVTAVTTTATSGRTESDSDSDKNSDHS G--LKRKTPVLKMSVS-KRARKASSDLDQA-SVSPSEED-SES------------------------------------- -----------------------------------------PSESEKTSDQDFTPEKKTIARAPRRAPLGGRKKKKVPS- ----ASDSDSRADSDG----AKEEPVVTAQPSPSSSSSSSSSSASDSDVSI-----KKPPRGRK-PAEKPPPKPRGRRSK PERPPSTSSSDSDSDSG--EVDRISEWKRRDEERRRELEARRRREQEEELRRLREQEREEKE---RRKERAERG------ --GSSGEELEDE-EPVKK-RSRKARGRGTPSSSDSE-------------------------------------------- -------------PEGELGKEGKKLAKKSQ--LQGSESARKPGQKEKRGRPDEKPRARPVK--VERTRKRSEGLSLDRKG EKKK---EPSVEER---LQKLHSEIKFALKVDNPDVRRCLSALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMA KAAEVYTRLKSRVLGPKVEALQKVNKAGAEKERADGEKVE-EQPGEQAPRELAEDEPSTDRSAPVNGEAASQKGENTEDG AQEDGQDLEDGPRGGSSEELH--DSPQDSSDPARPGNEHQDHERMQLASESADDDDEDS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Canis_familiaris_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------WPHLLAAQGTIFGFAQRMQMP--NW--KI DDIADGAVKP----PPNKYPIFFFGTHETAFLG--PKDLFPYD---KCKDKYGKPNKR--KGFNEGLWEIQNNPHASYSA P---------------------LPVSSSDSEAPEADPAGGS---EDDEVRGVMAVTAVTATAASDRMESDSDSDKSSDNS G--LKRKAAALKMSVS-KRTRKASSDLDQA-SVSPSEEENSES------------------------------------- -----------------------------------------SSESEKTSDQDFTPEKKAVVRAPRRGPLAGRKKKKAPS- ----ASDSDSKAESDG----AKVEPVAVARSAPSSSSSSSSSSSSDSDVSV-----KKPPRGRK-PAEKPPPKPRGRKPK PERPPTSSSSDSDSD----EVDRISEWKRRDEERRRELEARRRREQEEELRRLREQEKEEKE---RRRER-ERGEAPA-- SGGSSGDELGDEDEPVRK-RGRKGRGRGPQSSSDSG-------------------------------------------- -------------PEAELQREAKKTAR------QSTEPTRRPSQKEKRGRPEERPRARPAK--VERTRKRSEGFPPDRKV EKKK---EPSVEEK---LQKLHSEIKFALKVDNPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKEVME KAAEVYTRLKSRVLGPKIEAIQKATRAGVEKERAEVEKAEEALAGEEAPMERVEDEANADLSAPVNGEATSQKGESMEDK EQEGGQNSEEGLGCGSSEEPLHNDNAREGSELDAPGKERQERARVRMDSESLDEED------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Pteropus_vampyrus_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MPHAFKPGDLVFAKMKGYP--HWPARI DDIADGAVKP----PPNKYPIFFFGTHETAFLG--PKDLFPYD---KWKDKYGKPNKR--KGFNEGLWEIQNNPHASYSA P---------------------LPVSSSDSEAPEADPAGGS---EDDEARGVMAVTAVTAAATSDRMESDSDSDKSSENS G--LKRKASALKMSAS-KRARKASSDLDQA-SMSPSEEENSES------------------------------------- -----------------------------------------SSESEKTSDQDFTPEKKAVVRAPRRGPLAGRKKKKPPS- ----ASDSDSKPESEG----AKGEPAAVARSASCSSSSASSSSSSDSDVSV-----KKPTRGRK-PAEKPPPKPRGRKPK PERPPSTSSSDSDSD----EVDRISEWKRRDEQRRRELEARRRREQEEELRRLREREQEEKEEKGRRREQAERGDALRGG SGASSADELRDEDQPVRKQRVRKGRARGPQSSSDSE-------------------------------------------- -------------AEAELDREAKKSAKKLQ--QQSTEPARRPSQKEKRGRPEEKPRARPAK--VERTRKRSEGFTPERKV EKKK---EPSVEEK---LQKLHSEIKFALKVDNPDVKRCLNALEELGTLQVTSHILQKNTDVVATLKKIRRYKANKEVME KAAEVYTRLKSRVLGPKIEAIQKAARTGAEKERTEAEKAEAALGGEDPPSERAEDEASADLSASVNGEATSQKGGSMEDK EQEEGQNSEEGPVGGSSEDLLHNDSVREGPDLDGPGQDRQERERVHVDSESLDDEDS----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Monodelphis_domestica_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MPHAFKPGDLMKKVLKGGW--QNVPRI DDIADGAVKP----PPNKYPIFFFGTHETAFLG--PKDLFPYE---KYKDKYGKPNKR--KGFNEGLWEIQNNPHASYSA P---------------------PPVSSSDSEVPENDPMAGSDAEDEAGL---MAVAAVTAASASEKMESDEESDKGSEHS G--IKRKAPPLKMPVA-KRARKASSDLDLA-SATPSEDENSES------------------------------------- -----------------------------------------SSESEKNSDQDFTPEKKTVVRAPRRGLVGGRKKKKVAS- ----GSDSDSKADSEEAH----------NKSVVVTKSDSDSDSDSDSDISV-----KKPSRGRK-PVEKPPPKPRGRKPK VERVPSSSSSDSDSDS---EVDRISEWKRRDEERRRELEEKRKREQEEELRRLREQEKEEKE---RKKERAEKED----- --THPNSDSSEAEIKDDEPIKKRGKKGRGRAPSTSD-------------------------------------------- -------------SEPELEKEVKKPTKKPQ--SQSLEPSKKPNQKEKRSRPEEKSRAKPVK--VERARKKSEVLP-ERRV EKKK---EPSVEEK---LQKLHSEIKFALKVDNPDVKRCLSALEELGSLQVTSQILQKNTDVVATLKKIRRYKANQEVME KAAEVYTKLKSRVLGPKVEANQKANKPALEKVKAEVEKIEDQLAGGEAPKEKTEEEPSADISTPVNGESTTQKGESGEDK EQEEGQNMGEGQRCGSSEDLHNDNIQE-DPELDRPGNDRQDRERVRMDSESLDEES------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Gallus_gallus_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MPHSFKPGDLVFAKMKGYP--HWPARI DDIADGAVKP----PPNKYPIFFFGTHETAFLG--PKDLFPYE---KYKDKYGKPNKR--KGFNEGLWEIQNNPHASYSA P---------------------PPASSSDSDIPENDPMGGSDAGDDEDD---AAMAAVTTEKMESDEDSDR----GSDHS G--LKRKSLAMKMPVA-KRPRKSSSE-DQG-SPSLTEEENSET------------------------------------- -----------------------------------------SSESEKNSDQDFTPEKKPVARAPRRMPAGGRKKKKVES- ----GSDSDSKVDSDSEMG---------NATVDMTKSDSNSDSDSD--VSV-----KKPQRGRK-PAEKPPPKPRGRKPK LERVPISSSSDSDSDS---DVDRISEWKRRDEERRRELEEKRKREQEEEIRRLREQEKEEKE---KRKEKAEKGE----- --EVHSDSDSS----ADDEVAKKGRKGRGKAPSSSD-------------------------------------------- -------------SELEMEKEVKKPTKKQ-----PSELSRKPNQKEKRGRAEEKPRNKPLK--VERGRKKSDLIP-ERRM EKKKAP-EPTVEEK---LQKLHSEIKFALKVDNPDIKRCLNALEELGALQVTSHILQKHTDVVATLKKIRRYKANKDVME KAAEVYTRLKSRVLGPKMEAIQKANKAGPEKDKGDVEKGQEKLSGGETQNEKGEEEMNADLSGPVNGESLSQKTEGTEEQ ERDKSRGPGAGELEAPSEEAHNN-----VQDYPSAER-----ERVRGESESVDDAEES---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------- >Anolis_carolinensis_HDGFRP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MSQEFKPGDLIFAKMKGYP--HWPARV DEVPDGAVKP----PTNKMPIFFFGTHETAFLG--PKDIFPYA---ENKEKYGKPNKR--KGFNEGLWEIDNNPKVKFSS QQSQPAVNTADDKETHEDTSLDATEGSEQKMGPKRRKATALKGSVKQDS-LDTEVEIEEKEMETPKED-DSSEKQISEDV VKSGDVPVPKVARRGRKRKAEKQAELEEATVAA----AAATTVA------------------------------------ -----------------------------------------VVTVPKTSPKRGRPAATEVKIPKPRGRPKLIKPTCPPE- --------------------------------------SNTVNEEDKTKR---------------------------KGA DEKIPKKQ-KKDEESQR---EEDKVRKDPDKKEGKKEVETKKKTTTKLG--SASDSEEDGEEQ----------------- ---------------