>HUMAN_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAAAP-PSYCFVAFPPRAKDG---LV VFGKNSAR--PRDEVQEVVYFSAADH-EPESKVE----CTYISIDQVPRTYAIMISRP-AWLWGAEMGANEHGVCIANEA INTR--EPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIG KYWAAEKVTEGVRCICS-QLSLTTKMDAEHPELRSYAQSQGWWT--GEGEFNFSEVFSPVED-------HLDCGAGKDSL E-KQEES--ITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQ-NRSSPCIHYFTGTHDPS-RSIFKPFIFVDDVKLV PKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIES-DQEQGRKLRSTMLELEKQGLEAMEEILTS--SEPLD PAEVGDLFYDCVDTEIKFFK------------ >MOUSE_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MSGAP-PSYSFVALPPRAKDG---LV VFGKNSAR--PRDEVQEVVYFPAVDH-DAESKVE----CTYISIDQVPRTHAIVISRP-AWLWGAEMGANEHGVCIANEA INAR--EPAAETEALLGMDLVRLGLERGTTAKEALDIIVSLLDEHGQGGNYYEDAHSCHSFQSAYLLVDRDEAWVLETVG KYWAAERITEGVRCICN-HLSLATKLDEEHPELRTYAQSQGWWT--GDDEFNFAQVFSPADD-------RLDCCAGQDSL E-KQEES--ITVQTMINILRDKASGVCIDSESFLTTASIVSVLPQ-NRSSPCIHYFTGTPDPS-RSIFKPFIFVDDVKLV PKAQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAVIES-DEEQGRTLRKTMLELEKQGLEAMDEILSS--PEPPD PAEVGDLFYDCVDTEMKFFK------------ >RAT_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MSGAP-PSYSFVALPPRAKDG---LV VFGKNSAR--PRDEVQEVVYFPAVDH-EAESKVE----CTYISIDQVPRTHAIVISRP-AWLWGAEMGANEHGVCIANEA INAR--EPAAETEALLGMDLVRLGLERGTTAKEALDIIVSLLDEHGQGGNYYEDAHSCHSFQSAYLLVDRDEAWVLETVG KYWAAERITEGVRCICN-HLSLTTKMDEEHPELRTYAQSQGWWT--GEDEFNFAQVFSPADD-------HLDCCAGKDSL E-KQEES--ITVQTMINILRDKASGVCIDSESFLTTASIVSVLPQ-NRSSPCIHYFTGTPDPS-RSIFKPFIFVDDVKLV PKAQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAVIES-DQEQGRTLRKTMLELEKQGLEAMEEILSS--PEPPD PAEVGDLFYDCVDTEMKFFK------------ >DOG_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAVAP-PSYCFVAFPPRAKDG---LV VFGKNSAR--PRDEVQEVMYFSAADH-EPESKVE----CTYISIDQVPRTHAIVISRP-AWLWGAEMGANEHGVCIANEA INAR--EPAAETEALLGMDLVRLGLERGTTAKEALDVIVALLEEHGQGGNYYEDADSCHSFQSAYLIVDREEAWVLETVG KYWAAEQITEGVKCICN-QLSLTTKIDAEHPELRSYAQSQGWWT--GEDEFNFSQVFSLADD-------HLDCCAGKDSL E-KKEES--ITVQTMIDILRDKASGVCIDSESFLTTASVVSVLPQ-NRSSPCIHYFTGTPDPS-RSIFKPFIFVDDVKLV PKAQSPCFGDNDPAKKEPRFLEKPDRRHELYKAHEWARAVIES-DQEQGRKLRKTMLELEKQGLEAMEEILTS--SDPLD PTEVGDLFYDCVDTEIKFFK------------ >COW_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAVAP-PSYCFVAFPPRAKDG---LV VFGKNSAR--PRDEVQEVVYFSAADH-EPESKVE----CTYISINQVPRTHAIVISRP-AWLWGAEMGANEHGVCIANEA INAR--EPAAETEALLGMDLVRLGLERGATAKEALDVIAALLEEHGQGGNYYEDANSCHSFQSAFLIVDREEAWVLETVG KYWAAEKITEGVKCICN-QLSLTTKIDAEHPELRSYAQSQGWWM--GEDEFNFSEVFSPADD-------HLTCCSGRDTL E-KQEES--ITVQTMIDVLRDKASGVCVDSESFLTTASVVSVLPQ-NGSSPCIHYFTGTPDPS-RSIFKPFIFVDDVKLV PKAQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAVLES-DEEQGQKLRKTMLELEKQGLEAMEEILTS--SDPLD PTEVGDLFYDCVDTEIKFFK------------ >PLATYPUS_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAAAP-PSYCFVAFPPCAKDG---LV VFGKNSAR--PRDEVQEVVYIPAAVH-ESESKVE----CTYIAIDQVQKTHAIVLSKP-AWLWGAEMGANEHGVCIANEA IVTR--EPAAEREALLGMDLVRLGLERGATAKEALDVIVSLLEEHGQGGNYYEDGNFCHTFQSAYLIVDREEAWVLETIG KYWAAEKMTEGIKCVRT-QLSVTTKIDAEHPELRSYAESQGWWT--GDKEFNFSEVFSQEDD-------HIGCCSGKDSL E-KQEGT--ITVQTMINVLRDKASGVCVDSESFLTTASIVSVLPQ-NGTSPCIHYFTGTPDPS-RSIFKPFIFVDDVKLV PKTQSPSFGEDDPVRKEPRFLEKPDRRHELYKAHEWARAIIES-DQDQGHKLMATMLDLEKQGLEAMEDILTS--FEPLD PAEVVDLFYDCVDTEIKFFK------------ >OPOSSUM_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MSVAP-PSYCFVAFPPRAKDG---LV VFGKNSAR--PRDEVQEVVYIAAADH-EPDSKVE----CTYIAIDQVPRTHAIVISRP-AWLWGAEMGANEHGVCIANEA INTR--EPAPESEALLGMDLVRLGLERGATAKEAFEVIVSLLEEHGQGGNYYEDGDSCHTFQSSYLIVDREEAWVLETIG KYWAAEKITEGVRCVCN-QLSLTTKMDAEHAELRNYAEGQGWWT--TDQEFNFSEVFSQADD-------HRGCCSAKDSL E-KHEES--ITVETMMNILRDKASGICVDSDSFLTTASIVCVLPQ-GGSSPCIHYFTGTPDPS-RSIFKPFIFVDDVKHV PKVQSPCFGEEDPAKKEPRFLEKPDRRHELYKAHEWARAVIEN-DQDQGHKLMKTMLDLEKQGLEAMESILSS--TDPLD PTEVADLFYDCVDTEIKFFK------------ >HORSE_SCRN1 MAHDGTFKTKESAWTCALPYQAERGAAAPAAQTRRVRLGPGTPGGERRGWARRSLAAPDVAAVIAAAATPAPSAHPRRPQ DQHRRAEPGARHPAGEPRLARPGTQGVCSCFPARVSSRSAIAVPVPRRLQLSLPTRGYRYPGSNPAGANLGGLGSLGVRG EVALAQGWVTWAILRFPDIPVAGPLGCVPCAPCTPATPRATPAQRGWWSGPGTFAGVFVVVVEEIGFVLWRLSRSGLCWC IPTVPFVFPVSRWLELEALSFRFGSLKTSWLDLECVLHVRCKPSLRGYRSIGAWMPVAP-PSYCFVAFPPRAKDG---LV VFGKNSAR--PRDEVQEVVYFSAADH-DPESKVE----CTYISIDQVPRTHAIVISRP-AWLWGAEMGANEHGVCIANEA VNAR--EPAAETEALLGMDLVRLGLERGTTAKEALDVIVALLEEHGQGGNYYEDADACHSFQSAYLIVDREEAWVLETIG KYWAAEKITEGVKCICN-QLSLTTKIDAEHPELRSYAQSQGWWT--GDDEFNFSEVFSPADE-------HLDCCAGKDSL E-KQEES--ISVQTMIDILRDKASGVCIDSELFLTTASVVSVLPQ-NRSSPCIHYFTGTPDPS-RSIFKPFIFVDDVKLV PKAQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAVIES-DQEQGRKLRKTMLELEKQGLEAMEEILTS--SAPLD PTEVGDLFYDCVDTEIKFFK------------ >CHICKEN_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAEAP-PSYCFVAFPPCSKDG---LV VFGKNSAR--PRDEVQEVVYFAAATH-DPGSKVE----CTYIEIEQVPKTHAVALSRP-SWLWGAEMGANEHGVCIANEA VVTR--EPASESEALLGMDLVRLGLVKGSTAKEALDVIVALLEEHGQGGNYYEDASSCHAFQSAFLIVDRNEAWVLETSG KYWAAEKITEGVKCICN-QLSLTTKIDAEHPELRDYVRSQGWWN--GDSDFNFSEVFSLAAD-------HLACCSGRESL E-KQSGD--VSAQTMIDVLRDKDSGVCVDSESFLTTASIVSVLPQ-DPSFPCVHYFTGTPDPS-RSVFKPFIFVDDVKLV PKVQSPSFGDDDPAKKIPRFQEKPDRRHELYKAHEWARSLLES-DQEKGQKLMSIMLDLEKQGLEAMEDILTR--TEILD PAEVVDLFYDCVDTELKFFK------------ >ZEBRAFINCH_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAAAP-PSYCFVAFPPCSKDG---LV VFGKNSAR--PRDEVQEVVYFAAAEH-DPGSKVE----CTYIEIEQVPKTHAVVLSRP-SWLWGAEMGANEHGVCVANEA VVTR--EPASESEALLGMDLVRLGLERGATAKEALDVIVALLEEHGQGGNYYEDGSSCHTFQSAFLIVDRNEAWVLETSG KYWAAEKITEGVKCICN-QLSLTTKIDAEHPELRNYVKSQGWWN--GDSDFNFSEVFSLADD-------HLACCSGRESL E-KQGGD--VSAQAMIDVLRDKDSGVCVDSESFLTTASIVSVLPQ-DPSFPCIHYFTGTPDPS-RSIFKPFIFVDDVKLV PKVQSPSFGNDDPAKKIPRFQEKPDRRHELYKAHEWARSLLEN-DQDKGQKLMRIMLDLEKQGLEAMEDILSR--TEILD PAEVVDLFYDCVDTELKFFK------------ >MEGABAT_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MPVAP-PSCCLVAFPPRAKDG---LV VFGKNSAR--PRDEVQEVVYFSAANH-EPESKVE----CTYISIDQAPRTHAIVISRP-AWLWGAEMGANEHGVCIANEA MNAR--EPAAETEALLGMDLVRLGLERGSTAKEALDVIVALLEEHGQGGNYYEDADACHSFQSAYLIVDREEAWVLETIG KYWAAEKITEGVRCICN-QLSLTTKIDAEHPELRSYAQSQGWWT--GEDEFNFSEVFSPADD-------HLDCCAGKDSL E-KQEES--ITVQTMIDILRDKASGVCIDSESFLTTASVVSVLPQ-NTSSPCIHYFTGTPDPS-RSIFKPFIFVDDVKLV PKAQSPCFGDNDPAKKEPRFQEKPDRRHELYKAHEWARAVIAG-DQEQGQKQRKTQ-ELEKQGLEAIEEIPTS--AGPRV LVEVGDILYDCADTEIKFFK------------ >MICROBAT_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------CTYISVDQVPKTHAIVISRP-AWLWGAEMGANEHGVCIANEA VNAR--EPAAETEALLGMDLVRLGLERGSTAKEALDVIVALLEEHGQGGNYYEDAGSCHSFQSAYLIVDREEAWVLETVG KYWAAEKVTEGVRCICN-QLSLTTKIDAEHPELRSYAQSQGWWT--GEDEFNFSEVFSPTDD-------HLHCCAGKDSL E-KQEEG--ITVQTMIDILRDKASGVCIDSESFLTTASMVSVLPQ-SRGSPCIHYFTGTPDPS-RSIFKP-IFVDDVKLV PKAQSPCFGDDDPARREPRFQEKPDRRHELYKAHEWARAVIAS-GQ---------------------------------- -------------------------------- >ELEPHANT_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------CTYISIDQVPRTHAIVISRP-AWLWGAEMGANEHGVCIANEA INTR--EAAAETEALLGMDLVRLGLERGTTAKEALDVIVSLLEEHGQGGNYYEDANSCHSFQSAYLIVDREEAWVLETIG KYWAAEKITEGVKCVCS-HLSLTTKIDAEHPELRNYAQSQGWWT--GEDEFNFSEVFSPADD-------HLDCCAGKDSL E-KQEES--ITVQTMIDILRDKASGVCIDSESFLTTASTVSVLPQ-NRSLPCIHYFTGTPDPS----------------- -------------------------------------------------------------------------------- -------------------------------- >ARMADILLO_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAVAP-PSYCFVAFPPRAKDS---LV VFGKNSAR--PRDEVQEVMYFSAADH-EPESKVE----CTYISIDQVPRTHAIVISRP-AWLWGAEMGANEHGVCIANEP INTR--EPAAETEALLGMDLVRLGLERGTTAKEALDVIVSLLEEHGQGGNYYEDANSCQSFQSAYLIVDCEEAWVLETIG KYWAAEKITEGVKCICN-QLSLTTKIDREHPELRNYAQSQGWWT--GEDEFNFSEVFSPADD-------HLDCCAGKDSL E-KQEES--ITVETMMNILRDKASGVCIDSEAFLTTASIVSVLPQ-NRSLPCIHYFTGTPDPS-???????????????? ???????????????????????????????????????????-??EQGRKLRKTMLELEKQGLEAMEEILAS--SDPLD PAEVGDLFYDCVDTEIKFFK------------ >ANOLELIZARD_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MALPP-PSYSFVAFPPHTKDG---LV IVGKNSAR--PRDEVQEVVYFAAATH-DPGCKVE----CTYMEIDQVTRTNAIALSRP-SWLWGAEMGANEHGVFIANEA IVTK--EPALETEALLGMDLVRLGLERGATAKEALDVIVSLLEEHGQGGNYYEDGNLCHAFQSAYLIVDRNESWVLETIG KYWAAEKITEGVKCICN-QISLTTKIDAEHPELRNYAESQGWWT--TDTEFNFAQVFSPSDK-------HANCCLGKESL E-KQEGS--ITVQTMIDVLRDTSGGICVDSESFLTTASMVSVLPQ-NLSSPCIHYFTGTPDPS-RSIFKPFIFVDNVKFV PKIQSPSLGCSDPTKKVPRFQEKPDRRHELYKAHEWARSVMEN-DEDKGEELRTTMLNLERQGLEAMESLINS--SESLD ASEVEDLFYDCVDTEIKFFK------------ >FUGU_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------LSLKCPPSSLPPNPRVMEEAPMSCDCFVSLPPGSRDN---HV IFGKNSDR--PRDEVQEVVHFPAASH-PPGSTLE----CTYIQIPQLEHTHAVILSKP-AWMWGAEMGANDQGVCIGNEA VWTR--ETVNSEEALLGMDLVRLGLERGDSAWAALTVITGLLEQYGQGGQCREDP-APFSYHNTFLLVDREAAWVLETSG RLWVAQKITEGVKNISN-QLTIGSEISAEHPELRSVAQAQGWWD--GEGEFNFSQVFSPENPPARMELAKQRYKGGTELL H-HHDGSGAVTAEVMMSILRDKASGICMDSGGFCTTGSMVSILPR-DTSLPCIHFFTATPDPS-RSIFKPFVFSDSCTPV LGVVSPQFGPEDPVRKQPRFQSQVDRRHELYKCHQVALSIMET-HPNEGSAILEILRELESQCLSEISAMLNG--EIP-- GQDLGELFFDCVDAEIKFYQ------------ >STICKLEBACK_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAEVPVSCDCFVSLPPGSRDD---HV IFGKNADR--PRDEVQEVAHCPGASH-PAGATLE----CTYIQIPQVERTRAVVLSKP-AWMWGAEMGANDQGVCIGNEA IWTR--EPVCPGDALLGMDLVRLGLERGDSAWSALTVITSLLEQHGQGGQCKEDP-VAFSYHNTFLLVDRNEAWVLETAG RLWVAQKVTEGVKNISN-QLTIGAEVTAEHPELRRAAQAQGWWD--GESEFNFSRVFSPENPPARMELAKQRYKGGTELL K-QHDGS--VTAAVMMSILRDKPSGICMDSGGFCTTGSMVSVLPR-DPSLPCIHFFTATPDPS-RSIFKPFIFSDFSTPV LRVVSPQFGPDDPVRKQPRFQSKVDRRHDLYKAHQEAVSTMEN-NPDEGSSVFGILRELESQCLSEISAMLSG--EIP-- GEELGDLFFDTVDTEIKFYQ------------ >TETRAODON_SCRN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------FSLR------------MEEAPRSCDCFVSLPPGSRDN---HV IFGKNSDR--PRDEVQEVVHHPAASH-PSGSTLQ----CTYIQIPQEEYTHAVVLSKP-AWMWGAEMGANDRGVCIGNEA VWTR--ETVNAEKALLGMDLVRPGLERGDSARAALTVITGLLEQHGQGGPCREDP-APFSYHNTFLLVDRTEAWVLETSG RLWVAQQITEGVKNISN-QLTIGAEISAEHPELRSVAQAHGWWD--GQGEFNFSQVFSPENPPARMELAKQRYKGGTELL H-HYDGS--VTAEVMMSILRDKASGICMDSGGFCTTGSMVSILPR-DASLPCIHFFTATPDPS-RSVFKPFIFSESCTPV LRVVSPQFGTDDPVRKQPRFQNRVDRRHELYKSHQVALSAMET-EPDEGLGILEILRELESQCLSEISAMLNG--EIS-- GQDLGELFFDCVDAEIKFYQ------------ >HUMAN_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MASS--------SPDSPCSCDCFVSVPPASAIP---AV IFAKNSDR--PRDEVQEVVFVPAGTH-TPGSRLQ----CTYIEVEQVSKTHAVILSRP-SWLWGAEMGANEHGVCIGNEA VWTR--EPVGEGEALLGMDLLRLALERSSSAQEALHVITGLLEHYGQGGNCLEDA-APFSYHSTFLLADRTEAWVLETAG RLWAAQRIQEGARNISN-QLSIGTDISAQHPELRTHAQAKGWWD--GQGAFDFAQIFSLTQQPVRMEAAKARFQAGRELL R-QRQGG--ITAEVMMGILRDKESGICMDSGGFRTTASMVSVLPQ-DPTQPCVHFLTATPDPS-RSVFKPFIFGVGVAQA PQVLSPTFGAQDPVRTLPRFQTQVDRRHTLYRGHQAALGLMER-DQDRGQQLQQKQQDLEQEGLEATQGLLAG--EWAPP LWELGGLFQAFVKRESQAYA------------ >MOUSE_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MASS--------SPDAPCSCDCFVSVPPASAIP---AV IFAKNSDR--PRDEVQEVVFIPAGTH-VPGSRLQ----CTYIEVEQVGKTHAVILSRP-SWLWGAEMGANELGVCIGNEA VWTK--EPVGQGEALLGMDLLRLALERSSTAQEAVHVIAGLLDRYGQGGSCREDP-EPFCYHNTFLLADRTEAWVLETAG SLWAAQRIQGGARNISN-QLSIGTDISAEHPELRSHAKAQGWWT--GQGLFDFAEVFSLTQQPVRMEAAKARFRAGCEML Q-RHQGN--ITAEVMMGILRDKESGICMDSGGFRTTASMVSVLPQ-DPTKPCVHFLTATPDPS-RSVFKPFIFEVGVSQS PQVLSPTFGAQDPVRILPRFQTRVDRRHSLYRGHQAALGLMED-EQEQAQQLRKKQQRLEQEGLEALRGLLTG--EQTPP AQGLGSLFQAFVEREEQAYA------------ >RAT_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MASS--------SPDAPCSCDCFVSVPPASAIP---AV IFAKNSDR--PRDEVQEVVFIPAGTH-TPGSRLQ----CTYIEVEQVWKTHAVILSRP-SWLWGAEMGANELGVCIGNEA VWTK--EPVGEGEALLGMDLLRLALERSSTAQAAVHVIAGLLDRYGQGGSCREDP-EPFCYHNTFLLADRTEAWVLETAG RLWAAQRIQGGARNISN-QLSIGTDISAEHPELRSHAKAQGWWS--GQGVFDFAEVFSLTQQPVRMEAAKARFRAGCEML Q-RQQGS--ITAEVMMDILRNKESGICMDSGGFRTTASMVSVLPQ-DPTKPCVHFLTATPDPS-RSVFKPFIFEVGVSQP PQVLSPTFGAQDPVRILPRFQTQVDRRHSLYRGHQAALGLMD--EQEQAQ-LRQEQQSLEQEGLEALRGLLTG--EQTPA PQELGSLFQAFVEREHQVYA------------ >COW_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MASW--------SPDTPCSCDCFVSVPPASALP---AV IFAKNSDR--PRDEVQEVVFVPAGTH-APGSRLQ----CTYIEVEQVSKTHAVILSRP-SWLWGAEMGANEHGVCIGNEA VWTK--EPVGEGEALLGMDLLRLALERGSSAREALHVITGLLERYGQGGSCREDP-TPFCYHNTFLLADRTEAWVLETAG RLWAARRIQEGVHNISN-QLSIGSDISAEHPELRPHAQVQGWWD--GQGTFDFAQVFSLSQQPVRMEAAKARFRAGQELL Q-QQQGG--ITAEVMMGILRDKESGICMDSGGFRTTASMVSVLPR-DTTQPCVHFLTATPDPS-RSVFKPFIFGVGAAQP PQVLSPTFGAQDPVRTLPRFQTQVDRRHPLYRGHQVALGLMES-EQARGQQLRQKQRDLEQEGLVAVRRLLTR--ECAPP AQELGGLFQAFVEKETQAYS------------ >PLATYPUS_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MALP--------SLSSPCSCDCFVSLPPASALP---AV IFAKNSDR--PRDEVQEVVYQPAACH-APGTRLR----CTYIQIEQVERTHAVILSRP-AWLWGAEMGANEFGVCIGNEA VWTR--EPVGQEEALLGMDLVRLGLERGSTAQEALRVITALLERHGQGGSCREDP-APFCYHNTYLLADRGEAWVLETAG QLWAAEKIQRGTRNISN-QLSIGEDITAEHPELRTRARAQDWWN--GQAAFNFAQTFSLAQQPVRMEAAKARFRCGRELL Q-GLQGT--LTAESMMEILRDKVSGICMDSGGFRTTASMVSVLPQ-DPARPCVHFLTATPDPS-RSVFKPFVFGAGVSQV PQVLSPSFGEGDPARTLPRFQHQVDRRHQLYRDHQAALEKAEN-DQAWAQRLQQVQRGLEQRGLEAVRGLLAG--EVTPA SWELASLFGRCVEQESKAYGQGPGQNQ----- >OPOSSUM_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MASPP-------LPDVPCSCDCFVSLPPASAIP---AV VFAKNSDR--PRDEVQEVVLVPSGTH-APGSRLQ----CTYIEVDQVERTHAVILSRP-AWLWGAEMGANEHGVCIGNEA VWTQ--EPVGQEEALLGMDLLRLGLERGSSAQEALKVITNLLEQYGQGGSCRENP-TPFCYHNTFLLADRKEAWVLETAG KLWAAQRIQEGARNISN-QLSIGTDITDEHPELRAHAQKQGWWD--GQTTFDFAHVFSLVHQPVRMEAAKARFKAGRELL K-QYQGG--ITATTMMGILRNKESGICMNSGGFRTTASMVSVLPQ-DSSKPCVHFLTATPDPS-RSVFKPFVFGVGVTQA PQVFSPTFGDKDPVRTHPRFQTQVDRRHPLYCGHQAALDLMES-DQEEGKQLQKKQQDLEQEGQETLRKLLAG--EQSLS PQEIASLFQAFVEKESQVYGQQL--------- >HORSE_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MASS--------NPDAPCSCDCFVSVPPASAIP---AV IFAKNSDR--PRDEVQEVVFMPAETH-VPGSQLQ----CTYIEVEQVSKTHAVILSRP-SWLWGAEMGANEHGVCIGNEA VWTK--EPVGEGEALLGMDLLRLALERSSSAQEALHVITGLLERYGQGGSCREDP-TPFCYHNTFLLADRTEAWVLETAG RLWAAHRIQEGAHNISN-QLSIGTDISAEHPELRTHAQAQGWWG--GQSTFDFAQVFSLTQQPVRMEAAKARFRAGRELL Q-QQQGG--ITAEVMMGILRNKESGICMDSGGFRTTASMVSILPR-DPTQPCVHFLTATPDPS-RSVFKPFIFGVGAAQA PQVLSPTFGAQDPARTLPRFQTQVDRRHILYRGHQVALGLMES-EQGQGQQLRQKQRDLEQEGLEAARELLAG--EWAPP PQELGGLFQAFVERESQVYA------------ >ZEBRAFISH_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAEPPRSCDCFVSLPPGSKED---YV IFGKNSDR--PRDEVQEVVYFPASSH-PPASTVE----CTYISIPQVEHTNAVVLSRP-AWLWGAEMGANEHGVCVGNEA VWTK--EPVNPEEALLGMDLVRLGLERGDSARAALNVITALLEQFGQGGACRETS-EPFSYHNTFLLVDRQEAWVLETAG KLWAAQKVTEGVKNISN-QLTIDFEISAEHPDLRSVAQAQGWWS--GEGDFSFTAVFSPDHPPARMEMAKQRYRGGTALL Q-QHNGS--VTAEVMMSILRDKASGICMDSEGFRTTGSMVSILPR-NPNMPCVHFLTATPDPS-RSVFKPFIFSESVRPV SMVMSPQYGPGDPVRTLPRFQHQVDRKHELYKAHQMAN----T-SSDAGVSLQDTMRYLESQCLEEIEAMLRG--EVQ-- GQELGDLFFDCVDAEIKFYQ------------ >FROG_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MSSSVPPSSVPSSSVPPSSCDCFVSLPPASLAS---VV LFGKNSDR--PRDEVQEIVFRPAGSH-PPGSKLK----CTYIEVEQVAETLAVLLSRP-AWLWGAEMGANEKGVCIGNEA VWTK--EPVTEGEALLGMDLVRLALERAPSAQQAVQVITDLLGRYGQGGSCREDP-EPLIYHNTFLLCDCSEAYVLETAG PYWAAERIVEGARNLSN-QLSISVCPWREHPQLRSHALQQGWWD--GQGDFNFSAVYSLEKQPVRMEAAKLRYGAGQELL R-MQAGH--ITVKSMLNILRDKKSGICMDSGGFRTTASMVSVLPR-SPDVPCIHLLTATPDPS-RSVYKPFIFGPHVTQV PWVLSPSFGEHDPTQQIPRFQTQVDRRHDLYRQHQGALEACKANKQEAEETLRKKQLKLEDENLHWVDTILDP--SDSAD PVGGSDMFLICVEKELELYKGIGEKQCTHTEV >HEDGEHOG_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MASL--------DPDTPRSCDCFISMPPASAIP---AV IFAKNSDR--PRDEVQEVVFVPAGTH-TPGSRLQ----CTYIEVEQVCKTHAVILSRP-SWLWGAEMGANEYGVCIGNEA VWTK--EPVGEKEALLGMDLLRLALERSSSAQEAVQVITDLLEHYGQGGSCWEDP-KMFCYHNTFLLADRTEAWVLETAG RLWAAQRIQEGVRNISN-QLSIGSDISAEHPQLRSHAQAQGWWD--GQGAFNFAQVFSLAQQPVRMEAAKARFQAGRELL Q-QHQGS--ITAEVMMDILRNKESGICMDSGGFRTTGSMVSILPR-DPAQPCIHFLTATPDPA-RSVFKPFVFGMGATQA PQVLSPTFGAQDPVRTLPRFQTQVDRQHTLYRGHQLALALMES-EQERGKQLQQEQQKLEQEGLEAVQRLLTG--EWTPH LQELSGLFQVFVERESQAYA------------ >MEGABAT_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MALW--------SPDTPCSCDCFVSVPPASAIP---AV IFAKNSDR--PRDEVQEVVFVPAGTH-TPGSRLQ----CTYIEVEQVLKTHAVILSRP-SWLWGAEMGANEHGVCIGNEA VWTK--EPVGEGEALLGMDLLRLALERSSSAREALHVITGLLEHYGQGGGCREDP-TPFCYHNTFLLADRTEAWVLETAG RLWAAQRIQEGARNISN-QLSIGTDISAEHPELRTHAQAQGWWG--GQGTFDFAQVFSLTQQPVRMEAAKARFQAGRELL Q-QQKGG--ITAEVMMDILRNKESGICMDSGGFRTTASMVSILPQ-DPTQPCIHFLTATPDPS-RSVFKPFIFGAGAAQA PQVLSPTFGAQDPIRTVPRFQTQVDRRHTLYREHQKALGLMDR-EQDQGQQLRQKQRDLEQEGLEAARGLLAG--EWAPP PQELGGLFQAFVERESQAYA------------ >ANOLELIZARD_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------NLS-------SPVPPSSCDCFVSLPPASAAR---EV IFGKNSDR--PKDEVQEVVYFPAECH-AKGTKVQ----CTYIEVEQVERTHAVILSRP-AWLWGAEMGANEHGVCIGNEG VWTK--EPVGKEEALLGMDLVRLGLERGSTAHEALQVITALLERYGQGGSCKEEP-TPFIYHNTFLLADRKEAWVLETAG RFWAAQRIREGALNISN-QLSIGTEITAEHKDLRQHAQKQGWWS--GKGEFSFREVFSLIHQPVRMEAAKARYCAGQQLL R-KHSGQ--ITAETIMAILSDKSSGICVDSEGFSTTGSMVSILPQ-DPHLPCIHLITATPDPS-RSIFKPFIFVPNIPSF PQVKSPSFGDKDPIKENPRFQSRVDRRHDLYRQHQLALENMGR-GQNESQRIQEAMQKFQQQILERMKNLLAG--SLTLK PQELADLFFNSVETELKLYK------------ >RABBIT_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------CTYIEVEQVSKTHAVVLSRP-AWLWGAEMGANEHGVCIGNEA VWTK--EPVGEGEALLGIDLLRLALERSSSAREAWQVITGLLERYGQGGSCREDP-TPFCYHNTFLLADRTEAWVLETAG RLWAAQRIQERARNLSN-QLSIGTDISAEHPELRTHARAQGWWD--GQGAFDFAQVFSLTQQPVRMEAAKARFRAGQELL R-HQQGA--LTAQAMMDILRNKESGICMDSGGFRTTASMVSVLPQ-DPTQPCVHFLTATPDPS-RSVFKPFV-------- -------------------------------------------------------------------------------- -------------------------------- >MEDAKA_SCRN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MAEPPMSCDCFVSLPPGSRDD---HV IFGKNSDR--PRDEVQEVAYYPAASN-PPDSMLE----CTFIQIPQVEQTHAVVLSKP-AWMWGAEMGANDQGVCIGNEA VWTK--EPVSPGEALLGMDLVRLGLERGDSARAALTVITDLLEQHGQGGQCREDP-EPFSYHNTFLLVDRHEAWVLETAG RLWVAQKVSEGVKNISN-QLTISTEISAEHPELRSVAQAQGWWD--GQEEFNFSQTFSPENPPTRMELAKQRYKGGTALI Q-QHNGS--MTAEVMMSILRDKPSGICMDSGGFCTTGSMVSVLPR-DMNLPCIHFFTATPDPS-RSIFKPFIFSDCPTRV LRVVSPQFGPDDPVRKQPRFRSRVDRRHDLYKAHQVALSNMES-KPDEGLAVYDILRDLESQCLSEISAMLNG--EIP-- GDELGDLFFDCVDTEIKFYHDEDVSP------ >HUMAN_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MEPFSCDTFVALPPATVDN---RI IFGKNSDR--LYDEVQEVVYFPAVVHDNLGERLK----CTYIEIDQVPETYAVVLSRP-AWLWGAEMGANEHGVCIGNEA VWGR--EEVCDEEALLGMDLVRLGLERADTAEKALNVIVDLLEKYGQGGNCTEGR-MVFSYHNSFLIADRNEAWILETAG KYWAAEKVQEGVRNISN-QLSITTKIAREHPDMRNYAKRKGWWD--GKKEFDFAAAYSYLDT-AKMMTSSGRYCEGYKLL N-KHKGN--ITFETMMEILRDKPSGINMEG-EFLTTASMVSILPQ-DSSLPCIHFFTGTPDPE-RSVFKPFIFVPHISQL LDTSSPTFELEDLVKKKSHFK--PDRRHPLYQKHQQALEVVNN-NEEKAKIMLDNMRKLEKELFREMESILQ---NKHLD VEKIVNLFPQCTKDEIQIYQSNLSVKVSS--- >MOUSE_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MEPYSCDTFVALPPATVGN---RV IFGKNSDR--LFDEVQEVIYCPAAVHNDLEKRLK----CTYIEVDQVPETYAVVLSRP-AWLWGAEMGANEHGVCIGNEA VWGR--EDISKEEALLGMDLVRLGLERADTAEKALDVIVDLLEKYGQGGNCAEG--KEFSYYNSFLIADRNEAWILETSG KYWAAERVQG-VRNISN-QLSITTKIDREHPDMRNYAKQRGWWD--GKEEFDFTAAYSYIDT-AAMMTSPSRYCQGYKLL D-KHRGN--ITFETMMEILRDRPSGINMKG-EFLTTASMVSVLPQ-DPSLPCIHLFTATPHPE-RSVFKPFIFVPHISPL LDTKSPTFEPERPVAKKPYVK--PDRRHPLYQKHQEALEMISN-SKEKGKTILDKMRKLEKAVSEEIESILQ---SGHLD EEKTVNLFPQYVKDEIKIYQSNISS------- >RAT_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MQPYSCDTFVALPPATVGN---RV IFGKNSDR--LFDEVQEVIYFPAAVHSDLEKRLK----CTYIEVDQVPETYAVVLSRP-AWLWGAEMGANEHGVCIGNEA IWGR--EDISKEEALLGMDLVRLGLERADTAEKALNVIVDLLGKYGQGGNCAEG--EEFSYYNSFLIADRNEAWILETSG KFWAAEKVQG-VRNISN-QFSITTKIDREHPDMRNYAKQRGWWD--GKEEFDFAAAYSYTDT-ATMMTSPSRYCQGHKLL N-KHKGN--ITYETMVEILRDRPSGINMKG-EFLTTASMVSILPQ-DPSLPCIHLLTGTPHPE-R--------------- -------------------------------------------------------------------------------- -------------------------------- >DOG_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MEPCSCDTFVALPPATVDN---RI IFGKNSDR--LCDEVQEIVYFPAAVHDNPREHLQ----CTYIEIDQVPETYAVVLSRP-AWLWGAEMGANEHGVCIGNEA VWGR--EEVCDEEALLGMDLVRLGLERADTAEKALNVIVDLLEKYGQGGNCSEGR-MVFSYHNSFLIADRNEAWILETAG KYWAAEKVQEGVRNISN-QLSITTKIDREHPDLRNYAKQKGWWD--GKKEFDFAATYSYLDT-AKMKISPGRYCEGYRLL N-KHKGN--ITFETMMEILRDKPSGINMEG-EFLTTASMVSILPQ-DSSLPCIHFFTGTPDPE-RSVFKPFIFVPNISQL LDTSSPTFGLEDPVKKKPRFQHKPDRRHPLYQKHQQALEVIDK-KEEKAKTLLDNMRKLEKELFKEIESILQ---NKHLD GDKIVNLFPQCVKDEIRIYKSNISP------- >COW_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MEPCSCDTFVALPPATIDN---RI IFGKNSDR--PCDEVQEVVYFPAAVHDNLKEHLK----CTYIEIDQVPETYAVVLSRP-AWLWGAEMGANEHGVCIGNEA VWGR--EKVCDEEALLGMDLVRLGLERGDTAEKALNVIVDLLEKYGQGGNCSEGR-MVFSYHNSFLIADRNEAWILETAG KYWAAEKVEEGVRNISN-QLSIMTKIDREHPDMRNYAKQRGWWD--GKKEFDFAATYSYLDT-AKMMISPGRYCEGYKLL N-KHKGN--ITFETMVEILRDKPSGINMEG-EFLTTASMVSILPQ-DSKLPCIHFFTGTPDPE-RSVFKPFIFVPNISQL LNTSSPTFELEDSVGKKLQFNSKPDRRHPLYQKHQQALEILDN-KTEKAKTMLDNMRKLEKELFKEMESVLQ---NKHLQ VDKIVNLLHQCTEDEIRIYKSNVSS------- >PLATYPUS_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MASRSMEPCSCDTFVALPPDTVDN---RI IFGKNSDR--PNDEVQEIVYFPAATH-NPEEKLE----CTYIEIEQVANTSAVVLSRP-SWLWGAEMGANEHGVCIGNEA VWGK--EEVSDEEALLGMDLVRLGLERGDTAEKALDIIVDLLEKYGQGGNCLESG-LLFSYHNSFLIADRKEAWILETAG KYWAAERIKEGCRNISN-QLSIASKIDREHPGMRNYARSQGWWD--GKTEFNFAAMYSYANT-ARMTTSGNRYWEGHKML N-KHKGA--ITSETMMKILRDKESGINMEG-GFLTTGSMVSILPQ-DPALPCIHFFTGTPDPD-RSVFKPFIFVPNITQL RGSSSPTFGPNDPVKK-PCFQSKPDRRHQLYQNHERAVMVIET-QKEKGRKILKEQRTLEKEKLKEMELVLQ---HKPLP GDQAKNLFSHCVQKEIEIYKSNVQLE------ >OPOSSUM_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------MTSAPPNYTFVALPPSTVGN---RI IFGKNSDR--PFDEVQEIIYFPAATH-SLEKKLE----CTYIEIEQVAETYAVVLSRP-SWLWGAEMGANEHGVCIGNEA VWGR--EEVCEEEALLGMDLVRLGLERADTAEKALNIIVDLLEKYGQGGNCSEN--MVFSYHNSFLIADRHEAWILETAG QYWAAEKVEEGVRNISN-QLCITTKIDREHPKMREYAKSKGWWD--GEKEFNFAAVYAYPNS-SGIITLSERYCEGNKLL N-KHKGN--ITFETMMEILRDKESGINMKG-AFQTTGSMVSILPS-DPSLPCIHFFTGTPHPE-RSVFKPFIFAPNLTHL LETISPTFGLEDPVKKHPRFQSKCDRRHPLYQRHDQAIEIMNA-DEEKGRKMLEEMRILEKEILKEMELVLQ---NKCLD ENRTIDLFSQCVKNEMKIYGPIIGSP------ >HORSE_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MKLCSCDTFVALPPATVDN---RI IFGKNSDR--PCDEVQEVVYFPAAVHDNLREHLK----CTYIEIDQVPETYAVVLSRP-AWLWGAEMGANEHGVCIGNEA VWGR--EEVCDEEALLGMDLVRLGLERADTAEKALNVIVDLLEKYGQGGNCSEGR-MVFSYHNSFLIADRNEAWILETAG KYWAAEKVQEGVRNISN-QLSITTKIDREHADMRNYAKQKCWWD--GKKEFDFAATYSYLDT-ANMMISPGRYCEGYKLL N-KHKGN--ITFETMMEILRDKPSGINMEG-AFLTTASMVSILPQ-DSSLPCIHFFTGTPDPE-RSVFKPFIFVPNISQL LDTSSPTFELEDPIKKKPHFKSKPDRRHPLYQKHQQALGAVDN-NEEKAKTMLDNMKELEKELFKEMESVLQ---NKHLD VDKIVNLFPQCTKDEIRIYKSNISS------- >CHICKEN_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MAARPPPRSCDTFVALPPAAAGG---RV VFGKNSDR--PSDEVQEVLYVPAAAH-PAGAQLE----CTYITVEQAEQTYAVVLSRP-SWLWGAEMGANEHGVCVGNEA VWGR--EEVCDAEALLGMDLVRLGLERADTAEKALTVIVDLLEKYGQGGNCMESH-MAFTYHNSFLIADRKEAWVLETSG KHWAAEKVEGGVRNISN-QLSITTKIDREHPEMREYAKSKGWWD--GEKEFDFAATYSYVNT-ARMTTSRSRYCEGYKLL N-KHKGA--ITAETMMEILRDKESGINMEG-GFMTTGSMVSVLPQ-DPNLPCIHFFTGTPDPA-RSVFKPFIFVPGITEL LKTSSPTFGPDDPVKKQPRFQSKPDRRHELYKKHESAAVVMET-MKGKGKKMLEEIQTLEKRKMSEMESILQ---NGYPD INQPVNLFSQCIDEELKIYG------------ >ZEBRAFINCH_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MFPRPPPRSCDTFVALPPAAPGG---RV VFGKNSDR--PADEVQEVVHFPAAAH-PPGAALE----CTYISIEQVERTHAVVLSRP-SWLWGAEMGANEHGVCIGNEA VWGR--EEVCDGEALLGMDLVRLGLERADTAEKALSVIVDLLEKYGQGGNCMEST-MAFTYHNSFLIADRKEAWVLETSG KYWAAEKVEGGVRNISN-QLSITTKIDREHPELKEYAKSNGWWD--GEKEFDFAATYSYVNT-ARMTTSGGRYCEGYKLL N-KHKGS--ITSEIMMEILRDKESGINMEG-GFMTTGSMVSVLPQ-QPNLPCIHFFTGTPDPA-RSVFKPFIFVPGITQL LKTTSPTFGHDDPVKKQPRFQSKPDRRHELYKKHESAAVVMET-LKDKGKEMLKEIQELEKQKISQMESILQ---NGCLD TKQVVNLFSQCVEEELKIYG------------ >ZEBRAFISH_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MYPRSCDTFVALPPSTEGQ---RI IFGKNSDR--PCDEVQEVVYFPAKEH-EPG-KVE----CTYIEIEQVEKTFAVVLSRP-AWLWGAEMGANEHQVCIGNEA VWGR--ESADGDEALLGMDLVRLALERADTAEKAVDVITDLLEKYGQGGNCMEDE-CGFTYHNSFLISDRKEAWVLETAG KHWAAERVEAGYRNISN-QYSITTKIDKEHPGMRTYAKEQGWWD--GESEFSFTDVYSYSST-ARIQAAGGRYCEGQKLL Q-KSNGH--ISAQTMMDILRDKESGINMEG-MFMSTGSMVSVIPK-ADHLPGVHFFTATPDPE-RSVFKPFVFVSDVPPL KHTSSPCFGEEDPVKKKPRFQSKPNRKHPLFLKHEVAAAIIDS-SGERGQKIEKEMRDLEKQKLEEMEKYLT---EGVED SSLLVHLFTDTVEEEFSVYSSA---------- >HEDGEHOG_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MEPYSCDTFVALPPATVGN---RI IFGKNSDR--LCDEVQEVVYFPAVVHDSLR-RLK----CTYIEIEQVPETYAVVLSRP-AWLWGAEMGANEHGVCIGNEA VWGR--EAVCDEEALLGMDLVRLGLERADTAEKALNVIVDLLEKHGQGGNCSEGT-MLFSYHNSFLIADRSEAWILETAG KYWAAEKVQEGVRNISN-QLSITTKIDREHPDMRNHAKQKGWWD--GQKEFDFAATYSYLDT-AKMTTSPGRFCEGYKLL N-KYK??--?????????????????????-??????????????-?????????????????-???????????????? ?????????????????????--????????????????????-??EKAKTMLDNMRKMEKELFKEMEAILQ---NKQFD VNKIVNLFPESTKDELRIYRSNISP------- >MEGABAT_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MEPCSCDTFVALPPATVEN---RI IFGKNSDR--LCDEVQEVVFFPAAVHDNLKEHLK----CTYIEIDQVPKTYAVVLSRP-AWLWGAEMGANEHGVCIGNEA VWGK--EEVCDEEALLGMDLVRLGLERADTAEKALDVIVDLLDKYGQGGNCSEGG-MIFSYHNSFLIADRKEAWILETAG KYWAAEKVQGGVRNISN-QLSITTKIDREHPEMRNYAKQKGWWD--GKKEFDFAATYSYIDT-AKMMISPSRYCEGYKLL D-KHKGN--ITFETMMEILRDKPSGINMEG-EFLTTASMVSILPQ-DSNLPCIHFFTGTPDPE-RSVFKPFIFVPNISQL LDTSSPIFELEDPVKKKPHFKIKLDRRHPLYREHQQALEVIYN-KEEKAKTMLDNMKKLEKELFKEMESILQ---NKHLD VDKIVNLFPQCTKDEIRIYMSNISS------- >ANOLELIZARD_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------LELSSCDTFVALPPATIGN---RI IFGKNSDR--PSDEVQEIVYFTAVTH-SPGEKLE----CTYIEIEQVPETYAVVLSRP-SWLWGAEMGANEHGVCIGNEA VWGK--EVVYDEEALLGMDLVRLGLERASTAEKAVFIIVDLLDKYGQGGNCTESH-MAFTYYNSFLIADRKEAWVLETSG KYWAAEKIGEGVRNISN-QLSVTTKIDREHPGVRSYATSQGWWD--GKKEFDFAATYSYVNT-ARMTTTRSRYCEGYKLL K-KYEGH--ITAETMMAILRDKESGINMEG-GFMTTGSMVSILPQ-EPSLPCIHFFTGTPDPE-RSFFKPFIFVPNIDQL LKTSSPVFGPEDPVKQQPRFQTKPDRRHELYKKHESAVHLIES-SKEKAEIIIEQIQKLEKEKISQMETILQ---NGHLD ADQVVHLFSNCTEEEICIY------------- >FUGU_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MKPSSCDTFVALPPSTEGQ---RI IFGKNSDR--PCDEVQEVVYFPARDY-NAGEKLEVREKCTYIEIEQVSHTHAVILSKP-AWLWGAEMGANEHQVCIGNEA VWGR--ESADGDEALLGMDLVRLGLERADTAEKAVDVITDLLEQHGQGGSCMEEE-CSFTYHNSFLISDRTEAWLLETSG KLWAAERLEGGYRNISN-QYGITTKIDKEHPQMREYARGKGWWD--GKSQFNFAVVYSYMTP-ARIEEAGSRYHEGKTLL D-RSNGH--ITAETMMDILRDKDSGINMEG-MFMTTGSMVSVIPR-DPSLPGVHYFTATPDPD-RSVFKPFIFVKNLKPL KETTSPSYGPDDPVKKKPRFQSKPDRKHQLFVKHELVAAVIES-HKERGKKITENMRKLEKETMSKMEKFLS---GGVDE PDLLVNLFLGSVQEEMCVYST----------- >MEDAKA_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------SKVKMLPSSCDTFVALPPSTEGP---YI IFGKNSDR--PSDEVQEVVYFPAKDY-AAEEKVEK---CTYIEIEQVAHTYAVVLSKP-AWLWGAEMGANEHQVCIGNEA VWGR--ESADGEEALLGMDLVRLGLERADTAEKAVTVITELLEKYGQGGSCLEDE-CSFTYHNSFLISDRVEAWLLETSG TYWAAEKIQGGNRNISN-QYCITTKIDKEHPGMREYARSNGWWD--GKTGFNFATVYSYLTT-ARIESAGSRYCEGKKLL EQRNEGH--ITAEVMMQILRDKDSGINMEG-MFMTTGSMVSVVPT-DPALPAVHYFTGTPDPE-RSVFKPFIFVENAHLL KETSSPRFGPDDPVKKKPRFQSKPDRKHPLFVKHELVAAIIDT-HKDRGQKIIEGMRQLEKESLKEMEGILS---RSVDE PDLLVDLFSLSVQKEISLYSKRKKK------- >STICKLEBACK_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MLPSSCDTFVALPPSTEGQ---RV IFGKNSDR--PCDEVQEVVYLPARDH-GAGEKLE----CTYIEIEQVAHTYAVVLSKP-AWLWGAEMGANEHQVCIGNEA VWGR--ESADGDEALLGMDLVRIGLERADTAEKAVDVITELLQKYGQGGTCMEDE-CSFTYHNSFLISDRKEAWLLETSG KHWAAERVEGGYRNISN-QYSITTKIDKEHPEMREYARGQGWWD--GATPFNFSTVYSFTTT-ARIEASGSRYCEGKKLL E-KNDGH--ITAETMMDILRDKDSGINMEG-LFMTTGSMVSVIPT-DPTLPGVHYFTATPDPE-RSVFKPFVFVKNNNEL KETSSPSYGADDPVKKKPRFQSKPDRKHALFLKHELVAAVIEV-HEDRGKKITEGIRTLEKEKRTQMEEILT---NGIVE QDFLANLFSSCVQGEMGLYERHYGS------- >TETRAODON_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MKPSSCDTFVALPPSTEGQ---HI IFGKNSDR--SCDEVQEVVYFPARDY-NAGEKLE----CTYIEIEQASHTHAVVLSKP-AWLWGAEMGANEHQVCIGNEA VWGR--ESADGNEALLGMDLVRLGLERADTAEKAVDVISDLLERYGQGGSCMEDT-CSFTYHNSFLIADRTEAWLLETSG KLWAAERLGGGYRNISN-QYDITTKIDKEHLQMREYARSKGWWD--GKSPFNFAAVYSYMTP-GKIEEAGSRYHEGKTLL G-RSNGH--ITAEIMMDILRDKDSGINMEG-MFMTTGSMVSVIPR-DPSLPGVHYFTATPDPESRSVFKPFIFVENLKPL KETTSPSYGADDPVKRKPRFQSKPDRKHQLFVKHQLVGAIIEC-HKERGKKITDSMRRLEKEKMSQMEKFLS---GGLDE PDLLVDLFPSSVQEEMCVYSKN---------- >Anopheles_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MSGNGGETFVVLPP-CTESNRKQI IYGRNGTG--SAEQVTEVVYLPTADGSEPITLPS-------GCEIAAAASFGVILNKP-AGSWGAESGSNEKAVTIG--L SYS--EQGAGGDGKVSALDLVRLGLERGESASDAVDKLVALVEQHAP--------EDRNALKAAFVVCDPAAVWLLNVAG QFWAAKQIQESSVALAATGFTIGASFDRSTDDLASKAQAAGAWDGAGEFSFSEAFGGSPATDAVRSWPANEPGVEGAFGL K------------HMFECLRAVGT-------DPPTGPSHVSVLSG--EGELACHWFTATPQVS-ESVFKPFIFTAGAKIS PLTRVPE------------------------GEAQTLLYRLHS--NRKWELVGSLLSSLEATCVDEVNRFLS--EHSGEA SHELDELMKDCVEAEVKFYR------------ >Fruitfly_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTN--GDCFVVLPENCAEG---TL IIGRNAEDEKNVNVASEVCFYDATEVLEGKTDGG-------ASAETGGDMLRVILQKPQPGLWGGDFGANERGVALG--L TWAAGENEAKDSDSLLGTDIVRLTLAVAKDVDDAVDRIGALVASHGH--------DNS---KLNFIACDAAAAWLVSCSG KVWAAEKLEASFLRLPSGGLAVTTVVNKSSEGLDDAASFAAAHD---------AEAQAPAVDWCGPKPAG----DGTYTQ H------------DMFETLRSASN-------ASSSRAATVSVLSV--KG-ISCHWFTGTPNAA-ESVFKPFVFAPNPRIS PLTQVQA------------------------EADLTLLHKLHS--QRKPAALEHLR-SLELSCVDELNNYFS--LQD-HA SDELDELLKDCVEAEVKFYR------------ >Amphixous_SCRN3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------MADSSNQSHRCPKSCDTFVALPPATADG---HI IFAKNSDR--PANEVQEVVYFPEGSY-EAGTQLE----CTYITIPQVQHTHAVILSKP-AWMWGAEMGANQHGVCIGNEA VWSKLCGPDTEEERLLGMDLLRLGLERGSTAKEALDVMTTLLEQHGQGGPCMEEGGTPWCYDNSFIIADRREAWVLETAS RLWAAERITSGCRNISN-ELSVRTKIDAMSEGLKDHAQKHSYWSP-EEGDFDFARAYSQDLPNNIDEDPTGRAGAGKRLM E-KYSGS--IKAQTMFTILRDKKSGINMDG-SFRTTASMVSILPPPDTGTPCCHWFTATPDPS-KSVFKPFIFCNGVEIA KYTHSPERGADDPVRIKPRFQSNVDRRHPLYRAHEKAMMAAEG-NQDKRKELQKTMAELEEQCIMGMEAFLKDSAQDMAD EDEIRELFIDCVETEMKFYK------------