>Homo_sapiens_SH3GL1 ---------------------------------------------------------------------MSVAGLK---- KQFYKAS-QLVSEKVGGAEGT-KLDDDFKEMEKK--------------VDVT----SKAVTEVLARTIEYLQPNPASRAK LTMLNTVSKIRGQVKN---PGYPQSEGLLGECMIRHG-KELGGE---SNFGDA---LLDAGESMKRLAEVKDSLDIEVKQ N-FIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFEESKEVAETSMHNLLETDI--EQVSQLSALVDAQLDYHRQAVQILDELAEKLKRR---M REASSRPKREYKPK------------------PREPFDLGEPE--------------QSNGGFPC--------------- ----------TTAPKIA-----------------------------ASSSFRSSDKPIRTPSRSMP-PLDQPSCKALYDF EPEN-DGELGFHEGD---VITLTN--------------QIDENWYEG------------MLDGQSG-----FFPLSYVEV LVPLPQ--------------------------------- >Pan_troglodytes_SH3GL1 ---------------------------------------------------------------------MSVAGLK---- KQFYKAS-QLVSEKVGGAEGT-KLDDDFKEMEKK--------------VDVT----SKAVTEVLARTIEYLQPNP----- --------------------------------------------------GDA---LLDAGESMKRLAEVKDSLDIEVKQ N-FIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFEESKEVAETSMHNLLETD----------------------------------------M REASSRPKREYKPK------------------PREPFDLGEPE--------------QSNGGFPC--------------- ----------TTAPKIA-----------------------------ASSSFRSSDKPIRTPSRSMP-PLDQPSCKALYDF EPEN-DGELGFREGD---VITLTN--------------QIDENWYEG------------MLDGQSG-----FFPLSYVEV LVPLPQ--------------------------------- >Callithrix_jacchus_SH3GL1 -------------------------------------------------------------------------------- ----------------GAEGT-KLDDDFKEMEKK--------------VDVT----SKAVTEVLARTIEYLQPNPASRAK LTMLNTVSKIRGQVKN---PGYPQSEGLLGECMIRHG-KELG-E---SNFGDA---LLDAGESMKRLAEVKDSLDIEVKQ N-FIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFEESKEVAETSMHNLLGTDI--EQVSQLSALVDAQLDYHRQAVQILDELAEKLKRR---M REASSRPKREYKPK------------------PREPFDLGEPE--------------QSNGGLPC--------------- ----------TSAPKIT-----------------------------ASSSFRSSDKPIRTPSRSMR-ECPRPA------- -------------------------------------------------------------------------------- --------------------------------------- >Mus_musculus_SH3GL1 ---------------------------------------------------------------------MSVAGLK---- KQFYKAS-QLVSEKVGGAEGT-KLDDDFKDMEKK--------------VDVT----SKAVAEVLVRTIEYLQPNPASRAK LTMLNTVSKIRGQVKN---PGYPQSEGLLGECMVRHG-KELGGE---SNFGDA---LLDAGESMKRLAEVKDSLDIEVKQ N-FIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFEESKEVAETSMHNLLETDI--EQVSQLSALVDAQLDYHRQAVQILEELADKLKRR---V REASSRPKREFKPR------------------PREPFELGELE--------------QPNGGFPC--------------- ----------APAPKIT-----------------------------ASSSFRSSDKPIRMPSKSMP-PLDQPSCKALYDF EPEN-DGELGFREGD---LITLTN--------------QIDENWYEG------------MLHGQSG-----FFPLSYVQV LVPLPQ--------------------------------- >Canis_familiaris_SH3GL1 ---------------------------------------------------------------------MSVAGLK---- KQFYKAS-QLVSEKVGGAEGT-KLDEDFKEMEKK--------------VDVT----SKAVTEVLARTIEYLQPNPASRAK LTMLNTVSKIRGQVKN---PGYPQSEGLLGECMIRHG-KELGGE---SNFGDA---LLDAGESMKRLAEVKDSLDIEVKQ N-FIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GRIPDEELRQALEKFEESKEVAETSMHNLLETDI--EQVSQLCALVDAQLDYHRQAVQILDELADKLKRR---M RDASSRPKREYKPK------------------PREPFDLGEPE--------------QSNGGFPC--------------- ----------ATAPKIP-----------------------------ASSSFRSSDKPIRTPSRSMP-PLDQPSCKALYDF EPEN-AGELGFHEGD---VITLTN--------------QIDENWVPH------------PRQAHGT-----FLWHELPPP AVHTALTCAPQTGPQESSSLCSAEGQI------------ >Xenopus_tropicalis_SH3GL1 ---------------------------------------------------------------------MSVAGLK---- KQFYKAS-QLVSEKVGGAEGT-KLDDEFKEMEKK--------------VDVT----TKAVTDVLAKTIEYLQPNPASRAK LSMLNTMSKIRGQVKN---PGYPQPEGVLGETMIKFG-KDLGDE---SNFGDA---LLDAGESMKRLAEVKDSLDIEVKQ N-FLDPLQNLCDKDLKEIQHHLKKLEGRRLDYDYKKKRQ----------------------------------------- ------GKIPDEELRQAMEKFIESKEVAETSMINLLDTDV--EQVSQLTALVEAQLDYHRQAVQILDELSEKLKDR---V RESSSRTKREFKPK------------------PRESYEYAESE--------------QSNGGFS---------------- ----------NPSSKAP-----------------------------ASSSFRS-EKPARTNNRSSA-PLDQPCCKALYDF DPEN-DGELGFRESD---IITLTN--------------QIDENWYEG------------MINGQSG-----FFPVNYVEI LVPLPQ--------------------------------- >Danio_rerio_SH3GL1_a ---------------------------------------------------------------------MSVAGLK---- KQFYKAS-QMVSEKVGGAEGT-KLDEEFKDLERK--------------VDVT----NKAVVEVISKTSEYLQPNPASRAK LSMLNTMSKIRGQVKS---PGYPQAEGLLGECMGKYG-RELGEE---TNFGGA---LMEVGESMKRLAEVKDSLDIDVKQ N-FIDPLQGLCDKDLREIQHHLKKLEGRRLDYDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFHESKEVAEISMYNLLETDI--EQVSQLSSLVESQLQYHRQAVQILDELSDKLRDR---M KDAQTRPRKEYIPK------------------PKPVIDFGETNE-------------QSNGGYTP--------------- ----------SSAPP-MRN---------------------------AESYHQFGRITTRKPR---L-PAEQACCKALYDF EPEN-EGELGFHEGD---IITLTN--------------QIDENWYEG------------MLRGQSG-----FFPLNYVEV IVPLPH--------------------------------- >Takifugu_rubripes_SH3GL1_a ---------------------------------------------------------------------MSVAGLK---- KQFYKAS-QMVSEKVGGAEGT-KLDDDFRDLERK--------------VEVT----SKAVVEVISKTSEYLQPNPASRAK LSMLNTMSKIRGQVKN---PGYPQAEGLLGECMTKYG-RDLGEE---TNFGGA---LVDVGESMKRLAEVKDSLDIDVKQ N-FIDPLQGLCDKDLKEIQHHLKKLEGRRLDYDYKKKRQ----------------------------------------- ------GKIPDEEVRQALEKFHESKEVAETSMYNLLETDI--EQVSQLSSLVDSQLQYHRQAVQVLDELSDKLRDR---V NEAQSRPRREYTPK------------------PKPIFDFGDDS--------------HSNGGYSA--------------- ----------PMAPPPSRN---------------------------TGRHFLLSFILPPVSS---A-ALEQPSCKALYDF EPEN-EGELGFHEGD---IITLTN--------------QIDENWYEG------------MLNGQSG-----FFPLNYVEV LIPLPH--------------------------------- >Tetraodon_nigroviridis_SH3GL1_a ---------------------------------------------------------------------MSVAGLK---- KQFYKAS-QMVSEKVGGAEGT-KLDDDFRDLERK--------------VEVT----SKAVVEVISKTSEYLQPNPASRAK LSMLNTMSKIRGQVKN---PGYPQAEGLLGECMSKYG-RDLGEE---TNFGGA---LVDVGEAMKRLAEVKDSLDIDVKQ N-FIDPLQGLCDKDLKEIQHHLKKLEGRRLDYDYKKKRQ----------------------------------------- ------GKIPDEEVRQALEKFHESKEVAETSMYNLLETDI--EQVSQLSSLVDSQLQYHRQAVQVLEELSDKLRDR---V NEAQSRPRREYTPK------------------PKPIFDFGEDS--------------HSNGGYSA--------------- ----------PVALPPSRT---------------------------T------------------A-ALEQPSCKALYDF EPEN-EGELGFHEGD---IITLTN--------------QIDENWYEG------------MLNGQSG-----FFPLNYVEV LIPLPH--------------------------------- >Tetraodon_nigroviridis_SH3GL1_b ---------------------------------------------------------------------MSVAGFR---- KQFYKAS-QMVSEKVGGAEGT-KLDEDFKDLERK--------------ADVT----SKAVVELISKTSEYLQPNPATRAK LTMLGTVSKIRGQVKS---PGYPQPEGLLGECMTKYG-RDMGQN---TGFGGA---LIDFGESMLRLAEVKDSLDIDVKQ N-FIDPLQTVADKDIKDIQHHLKKLEGRRLDYDYKKKRQ----------------------------------------- ------GKIQDEEIRQALEKFHESKELAEGSMHNLLETDV--EQVSHLSSLVESLVQYHRQASQILEELSENLAKRNVQG RRTQSRPKREYTPK------------------PRPSFDYGRAD--------------NSNGGFTP--------------- ----------AATSPSNYS---------------------------A----------------------AEPCCRALYDF EPEN-DGELGFREGD---VIRLLS--------------RIDENWLEG------------SLGSRSG-----YFPVNYVEV TVPLPN--------------------------------- >Gasterosteus_aculeatus_SH3GL1_a ---------------------------------------------------------------------MSVAGFK---- KQFYKAS-QMVSEKVGGAEGT-KLDEDFKDLERK--------------VDVT----SKAVVEVISKTSEYLQPNPASRAK LSMLNTMSKIRGQVKN---PGYPQAEGLLGECMGKYG-RDLGEE---TNFGGA---LVDVGESMKRLAEVKDSLDIDVKQ N-FIDPLQGLCDKDLREIQHHLKKLEGRRLDYDYKKKRQ----------------------------------------- ------GKIPDEEVRQALEKFHESKEVAETSMYNLLETDI--EQVSQLSSLVESQLQYHRQAVQVLEELSDKLKDR---M NDAQTRPRREYTPK------------------PKPIYDFGEDN--------------QSNGGYST--------------- ----------SAAPPPSRN---------------------------SGSGIRVASHRKAT-----S-APEQPCCKALYDF DPEN-EGELGFREGD---VITLTN--------------QIDENWYEG------------MLNSQSG-----FFPLNYVEV LVPLPH--------------------------------- >Oryzias_latipes_SH3GL1_a ---------------------------------------------------------------------MSVAGLK---- KQFYKAS-QMVSEKVGGAEGT-KLDDDFRDLERK--------------VDVT----SKAVAEVISKTSEYLQPNPASRAK LSMLNTMSKIRGQVKN---PGYPQAEGLLGECMAKYG-RELGED---TNFGGA---LVDVGESMKRLAEVKDSLDIDVKQ N-FIDPLQGLCDKDLREIQHHLKKLEGRRLDYDYKKKRQ----------------------------------------- ------GKIPDEEIRQALEKFHESKDVAETSMYNLLETDI--EQVSQLSALVDSQLQYHRQAVQVLEELSDKLRER---M NEAQSRPRREYTPK------------------PKPIFDFGDNS--------------HSNGGYPT--------------- ----------TMAPPPSRN---------------------------PDITKEVQNPLTPACSSL-P-PPEQPSCKALYDF EPEN-EGELGFHEGD---VITLTN--------------QIDENWYEG------------MLNGQSG-----FFPLNYVEV LVPLPH--------------------------------- >Drosophila_melanogaster_SH3GL1 ---------------------------------------------------------------------MAFAGLK---- KQINKAN-QYMTEKMGGAEGT-KLDMDFMEMERK--------------TDVT----VELVEELQLKTKEFLQPNPTARAK MAAVKGISKLSGQAKS---NTYPQPEGLLAECMLTYG-KKLGEDN--SVFAQA---LVEFGEALKQMADVKYSLDDNIKQ N-FLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--------------------------------------- ----------DDEIRGAEDKFGESLQLAQVGMFNLLENDT--EHVSQLVTFAEALYDFHSQCADVLRGLQETLQEK---R SEAESRPRNEFVPK------------------TLLDLNLDGGGGGLN-EDGTPSHISSSASPLPS--------------- ---------PMRSPAKSM--------------------------------------------AVTPQRQQQPCCQALYDF EPEN-PGELAFKEND---IITLLN--------------RVDDNWFEG------------AVNGRTG-----YFPQSYVQV QVPLPNGN------------------------------- >Anopheles_gambiae_SH3GL1 ---------------------------------------------------------------------MAFAGLK---- KQINKAN-QYVTEKMGGAEGT-KLDLDFMEMERK--------------TDVT----VELVEELQAKTKEYLQPNPTARAK MAAVK--------------------EGILADCMLTYG-KKLGED---SIFASA---LVEMGDSLKQMADVKYSLDDNIKQ N-FLEPLHQLQTKDLKEVMHHRKKLQGRRLDFDCKKRRQAKG-------------------------------------- ------SQITDDEIRSAEEKFAESLQLAQVGMYNLLENDV--EQVSQLVTFAEGMLDYHSQCSEILKVLVETLNEK---R EEAAARPKSEFVPK------------------TLADLNIEMLG---S-QDG------MNASPLPS--------------- ---------PMRSPAR----------------------------------------------TPMPTKPTQPCCTALYDF EPEN-PGELGFKEND---VITLIQ--------------RVDENWFEG------------SLNGRNG-----YFPQSYVQV TVPLPSN-------------------------------- >Homo_sapiens_SH3GL2 ---------------------------------------------------------------------MSVAGLK---- KQFHKAT-QKVSEKVGGAEGT-KLDDDFKEMERK--------------VDVT----SRAVMEIMTKTIEYLQPNPASRAK LSMINTMSKIRGQEKG---PGYPQAEALLAEAMLKFG-RELGDD---CNFGPA---LGEVGEAMRELSEVKDSLDIEVKQ N-FIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFDESKEIAESSMFNLLEMD--IEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEER---I RQASSQPRREYQPK------------------PRMSLEFPTG------------DSTQPNGGLSH--------------- ----------TGTPKP------------------------------------------------SGVQMDQPCCRALYDF EPEN-EGELGFKEGD---IITLTN--------------QIDENWYEG------------MLHGHSG-----FFPINYVEI LVALPH--------------------------------- >Pan_troglodytes_SH3GL2 ---------------------------------------------------------------------MSVAGLK---- KQFHKAT-QKVSEKVGGAEGT-KLDDDFKEMERK--------------VDVT----SRAVMEIMTKTIEYLQPNPASRAK LSMINTMSKIRGQEKG---PGYPQAEALLAEAMLKFG-RELGDD---CNFGPA---LGEVGEAMRELSEVKDSLDIEVKQ N-FIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFDESKEIAESSMFNLLEMD--IEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEER---I RQASSQPRREYQPK------------------PRMSLEFPTG------------DSTQPNGGLSH--------------- ----------TGTPKP------------------------------------------------SGVQMDQPCCRALYDF EPEN-EGELGFKEGD---IITLTN--------------QIDENWYEG------------MLHGHSG-----FFPINYVEI LVALPH--------------------------------- >Macaca_mulatta_SH3GL2 -------------------------------------------------------------------------------- --------QKVSEKVGGAEGT-KLDDDFKEMERK--------------VDVT----SRAVMEIMTKTIEYLQPNPASRAK LSMINTMSKIRGQEKG---PGYPQAEALLAEAMLKFG-RELGDD---CNFGPA---LGEVGEAMRELSEVKDSLDIEVKQ N-FIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFDESKEIAESSMFNLLEMD--IEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEER---I RQASAQPRREYQPK------------------PRMSLEFPTG------------DSTQPNGGLSH--------------- ----------TGTPKP------------------------------------------------SGVQMDQPCCRALYDF EPEN-EGELGFKEGD---IITLTN--------------QIDENWYEG------------MLHGHSG-----FFPINYVEI LVALPH--------------------------------- >Callithrix_jacchus_SH3GL2 ---------------------------------------------------------------------MSVAGLK---- KQFHKAT-QKVSEKVGGAEGT-KLDDDFKEMERK--------------VDVT----SRAVMEIMTKTIEYLQPNPASRAK LSMINTMSKIRGQEKG---PGYPQAEALLAEAMLKFG-RELGDD---CNFGPA---LGEVGEAMRELSEVKDSLDIEVKQ N-FIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFDESKEIAESSMFNLLEMD--IEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEER---I RQASSQPRREYQPK------------------PRMSLEFPTG------------DSTQPNGGLSH--------------- ----------TGTPKP------------------------------------------------SGVQMDQPCCRALYDF EPEN-EGELGFKEGD---IITLTN--------------QIDENWYEG------------MLHGHSG-----FFPINYVEI LVALPH--------------------------------- >Mus_musculus_SH3GL2 ---------------------------------------------------------------------MSVAGLK---- KQFHKAT-QKVSEKVGGAEGT-KLDDDFKEMERK--------------VDVT----SRAVMEIMTKTIEYLQPNPASRAK LSMINTMSKIRGQEKG---PGYPQAEALLAEAMLKFG-RELGDD---CNFGPA---LGEVGEAMRELSEVKDSLDMEVKQ N-FIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFDESKEIAESSMFNLLEMD--IEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEER---I RQASSQPRREYQPK------------------PRMSLEFATG------------DSTQPNGGLSH--------------- ----------TGTPKP------------------------------------------------PGVQMDQPCCRALYDF EPEN-EGELGFKEGD---IITLTN--------------QIDENWYEG------------MLHGQSG-----FFPINYVEI LVALPH--------------------------------- >Canis_familiaris_SH3GL2 -------------------------------------------------------------------------------- ------------------------------MERK--------------VDVT----SRAVMEIMTKTIEYLQPNPASRAK LSMINTMSKIRGQEKG---PGYPQAEALLAEAMLKFG-RELGDD---CNFGPA---LGEVGEAMRELSEVKDSLDMEVKQ N-FIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFDESKEIAESSMFNLLEMD--IEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEER---I RQASSQPRREYQPK------------------PRMSLEFTTG------------DSTQPNGGLSH--------------- ----------TGTPKP------------------------------------------------AGAPMDQPCCRALYDF EPEN-EGELGFKEGD---IITLTN--------------QIDENWYEG------------MLHGQSG-----FFPINYVEI LVALPH--------------------------------- >Pteropus_vampyrus_SH3GL2 ---------------------------------------------------------------------MSVAGLK---- KHFHKAT-QKVSEKVGGAEGT-KLDDDFKEMERK--------------VDVT----SRAVMEIMTKTIEYLQPNPASRAK LSMINTMSKIRGQEKG---PGYPQAEALLAEAMLKFG-RELGDD---CNFGPA---LGDVGEAMRELSEVKDSLDMEVKQ N-FIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFDESKEIAESSMFNLLEMD--IEQVSQLSALVQAQLEYHKQAVQILQQVTIRLEER---I RQASSQPRREYQPK------------------PRMSLEFPTG------------DSTQPNGGLSH--------------- ----------TGTPKP------------------------------------------------AGAPMDQPCCRALYDF EPEN-EGELGFKEGD---VITLTN--------------QIDENWYEG------------MLHGQSG-----FFPINYVEI LVALPH--------------------------------- >Monodelphis_domestica_SH3GL2 ---------------------------------------------------------------------MSVAGLK---- KQFHKAT-QKVSEKVGGAEGT-KLDDDFKEMERK--------------VDVT----SRAVMEIMTKTIEYLQPNPASRAK LSMINTMSKIRGQEKG---PGYPQAEALLAEAMLKFG-RELGDE---CNFGPA---LGDVGEAMRELSEVKDSLDMEVKQ N-FIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEELRQALEKFDESKEIAESSMFNLLEMD--IEQVSQLSALVQAQLEYHKQASQILQQVTVRLEER---I REASSQPRREYQPK------------------PRMSLEFSSG------------DNSQHNGGLSH--------------- ----------TSTPKP------------------------------------------------SGAPMDQPCCRALYDF EPEN-EGELGFKEGD---VITLTN--------------QIDENWYEG------------MLHGQSG-----FFPINYVEI LVALPH--------------------------------- >Xenopus_tropicalis_SH3GL2 ---------------------------------------------------------------------LIIRTQK---- KQMKKIL-QKVSEKVGGAEGT-KLDEDFKEMERK--------------VDVT----SRAVMEIMTKTTEYLQPNPASRAK LSMLNTMSKIRGQEKG---PGYPQAEALLAEAMFKFG-REIGDE---SNFGLA---LIDVGDAMRELSDIKDCLDIDVKQ N-FIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKITDDEIRQALEKFDESKEIAESSMFNLLEMDDIVWEASNSNDLLHSYKYFHHPTYRIYLNICIKFYR----I REASSQPRREYQPK------------------PRMSLELENS---------------QLNGGIAL--------------- ----------AGTPKP------------------------------------------------SGAPMDQPCCRALYDF DPEN-EGELGFKEGD---IITLTN--------------QIDENWYEG------------MLHGQSG-----FFPINYVDI LVPLPH--------------------------------- >Danio_rerio_SH3GL2_a ---------------------------------------------------------------------MSVAGLK---- KQFHKAT-QRVSEKVGGAEGT-KLDVDFTEMEKK--------------VDTT----SRAVLDILTKTTEYLQPNPATRAK MSMMSSMSKIRGGDKG---PGYTQTETTLGEAMQKAG-RELGEE---SCFGVA---LIDVGEAMRELGEVKDALDMEVKQ N-FIDPLQNIHDKDLKEIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKVTEDEIKQALEKFDDSKEIAEQSMFNLLEND--IEQVSQLSALVQAQVNYHRQAAEILQQLSSKIEDR---I REASCKPKREYVPK------------------PRTSLDF----------------SENHNGSIG---------------- ----------HSGPSRS-------------------------------P-----------------APMDQPCCRALYDF DPEN-EGELGFKEGD---IITLTS--------------KIDDNWYEG------------MVNGQSG-----FFPVNYVDI LVALPH--------------------------------- >Takifugu_rubripes_SH3GL2_a ---------------------------------------------------------------------MSVAGLK---- KQFHKAT-QKVSEKVGGAEGT-KLDDDFREMEKK--------------VDVT----SRAVLDIMTKTTEYLQPNPASRAK LSMINTMSKIRGQEKG---PGYPQAETVLGDTMLKFG-RELGED---SSFGSA---LIEASEAMKELGEVKDALDMEVKQ N-FIDPLQNLHDKDLKEIQHHLKKMEGRRLDFDYKKKRQ----------------------------------------- ------GKVQDEEIKQALEKFDESKEIAEQSMFNLLESD--IPEVSQLAALVQAQLEYHRRSAEILQQLSSKMEDR---I KEASCKPRKEFTPK------------------PRMTLELLPP-------------SESHNGGIHS--------------- ----------AKSPGRS-------------------------------P-----------------APMDQPCCRALYDF EPEN-DGELGFKEGD---IITLTN--------------QIDDNWYEG------------MINGQSG-----FFPINYVDI LVPLPH--------------------------------- >Takifugu_rubripes_SH3GL2_b ---------------------------------------------------------------------MSVAGLK---- KQFHKAT-QKVSEKVGGAEGT-KLDDDFTEMEKR--------------VDTT----SRAVLDIMTKTTEYLQPNPATRAK MSMMNSMSRMRGQEKG---PGYTQTEAILGESMQKFG-RELGEE---SSFGLA---LVDIGEAMRELGEVKDALDMEVKQ N-FIDPLQNLHEKDLKEIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKVTEDELKQALEKFDDSKEIAEQSMFNLLECD--IEQVSQLAALVQAQLEYHSRSAEILTQLSSKIDER---I REASGKPRKEFAPK------------------PRTSLDFSI--------------SENHNGGIHG--------------- ----------ARSPARS-------------------------------P-----------------APMDQPCCRALYDF DPEN-EGELGFKEGD---IITLTN--------------KIDDNWFEG------------MLHGNSG-----FFPINYVDT LVPLPH--------------------------------- >Tetraodon_nigroviridis_SH3GL2_b ---------------------------------------------------------------------MSVAGLK---- KQFHKATQQKVSEKVGGAEGT-KLDDDFTEMEKR--------------VDVT----SRAVLDIMTKTTEYLQPNPATRAK MSMMNSMSRMRGQEKG---PGYTQTEAILGESMQKFG-RELGEE---SSFGLA---LVDIGEAMRD-GEVKDALDMEVKQ N-FIDPLQNLHEKDLKEIQHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------AKVTEDELKQALEKFDDSKEIAEQSMFNLLESD--IEQVSQLAALVQAQLEYHSRSAEILTQLSSKIDER---I REASGKPRKEFVPK------------------PRTSLDFSI--------------SENHNGGIHG--------------- ----------ARSPARS-------------------------------P-----------------APMDQPCCRALYDF DPEN-DGELGFKEGD---IITLTN--------------KIDDNWFEG------------MLHGNSG-----FFPINYVDT LVPLPH--------------------------------- >Gasterosteus_aculeatus_SH3GL2_a -------------------------------------------------------------------------------- --------QKVSEKVGGAEGT-KLDDDFKEMEKK--------------VDVT----SRAVLDIMTKTTEYLQPNPASRAK LSMINTMSKIRGQDKG---PGYPQAESVLGDAMLRFG-RELGDE---SSFGLA---LIDASEAMKELGEVKDALDMEVKQ N-FIDPLQNLHDKDLKEIQHHLKKMEGRRLDFDYKKKRQ----------------------------------------- ------GKVQDDEIKQALEKFDESKEVAEQSMFNLLESD--IEQVSQLAALVQAQLEYHSRSAEILQQLSSKMEDR---I KEVSAKPRKEYAPK------------------PRMTLELLPP-------------SESHNGGIHS--------------- ----------AKSPGRS-------------------------------P-----------------APLDQPCCRALYDF EPEN-EGELGFKEGD---VITLTN--------------QIDDNWYEG------------MINGQSG-----FFPINYVDI LVPLPR--------------------------------- >Oryzias_latipes_SH3GL2_a -------------------------------------------------------------------------------- -----SS-QKVSEKVGGAEGT-KLDDDFKEMEKK--------------VDIT----SRAVLDIMTKTTEYLQPNPASRAK LSMINTMSKIRGQDKG---PGYPQAETILGDAMLKFG-RELGEE---SSFGMA---LIDAGESIKELGEVKDALDMEVKQ N-FIDPLQNLHDKDLKEIQHHLKKMEGRRLDFDYKKKRQ----------------------------------------- ------GKVQDEEIKQALEKFDESKEIAEQSMFNLLESD--IEQVSQLAALVQAQLEYHSRAAEILQQLSSKMEDR---I KEVSSKPRKEYSPK------------------PRMTLELLPP-------------SESHNGGIHS--------------- ----------AKSPGRS-------------------------------PVYTSRIGFDSH---SLAAPMDQPCCRALYDF EPEN-EGELGFKEGD---IITLTN--------------QIDDNWYEG------------MINGQSG-----FFPINYVDI LVPLPH--------------------------------- >Ciona_intestinalis_SH3GL2 ---------------------------------------------------------------------MSLGGMK---- KQLNKAS-QYMSEKMGETEKT-KMDEEFIEMERK--------------VDAT----QKAVTDLINHTREYLQPNPAVRAK MNMMN---KLQG--KD---MKYRQVEGVLGEVMVKHG-TDLGHE---SNFGEA---LKEVGEGMIQLSEIKDSLDVSVKQ D-FIDPFYQSFDKDMKEVLHHRKKLSGRRLDYDYKRKKG----------------------------------------- ------AKVPHEEVVQAEQKLDESLELAGSSMFNLLAGDV--EQVRQLAALVEAQLEYHRQSADILESVNDKLNKQ---I EEINSKPEKERTKR------------------QLRTSSIAPADR----------TPTHTTPAIP---------------- ----------QASPRHTAP---------------------------------------------PPKAT-QPSCKAIFDF EPEN-EGELAFKEGE---ILTLVA--------------EIDDNWFEG-----------MSQNGDTG-----YFPKTYVEV VVPL----------------------------------- >Strongylocentrotus_purpuratus_SH3GL2 ---------------------------------------------------------------------MS---FAG-FK KQLNKAN-QFMSEKIAGAEKT-EYDEEFVDLEKT--------------IDVT----SLAVDDIITKTNELLQPNPLTRAK QSTAMTVSKMRGQTKN---SRYPQPEATLGDCFLKFG-RDLGEN---SVFGNG---LLEVGEAHKQLADIKDSLDFNIRQ N-FLEPLDHLRQKELKEIVHHRKKMQGRRLDYDCKKRKV----------------------------------------- ---------------QKGTTFT-----FHVSLFSFLYLHV----------------------KEFFLFLSCTFKNS---- -------CHHYFIG------------------------------------------------------------------ -------------------------------------------------------------------------------- ------------------IIALT----------------------------------------------------HFVLA VCVIT---------------------------------- >Homo_sapiens_SH3GL3 -------------------------------------------------------------MDGIFAGIICNQANR---- CLTWTSQ-QLFSEKISGAEGT-KLDDEFLDMERK--------------IDVT----NKVVAEILSKTTEYLQPNPAYRAK LGMLNTVSKIRGQVKT---TGYPQTEGLLGDCMLKYG-KELGED---STFGNA---LIEVGESMKLMAEVKDSLDINVKQ T-FIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRV----------------------------------------- ------GKIPDEEVRQAVEKFEESKELAERSMFNFLENDV--EQVSQLAVFIEAALDYHRQSTEILQELQSKLQMR---I SAASSVPRREYKPR------------------PVKRS-------------------SSELNGVS---------------- ---------TTSVVKTTG----------------------------------------------SNIPMDQPCCRGLYDF EPEN-QGELGFKEGD---IITLTN--------------QIDENWYEG------------MIHGESG-----FFPINYVEV IVPLPQ--------------------------------- >Pan_troglodytes_SH3GL3 -------------------------------------------------------------MDGIFAGIICNQANR---- CLTWTSQ-QLFSEKISGAEGT-KLDDEFLDMERK--------------IDVT----NKVVAEILSKTTEYLQPNPAYRAK LGMLNTVSKIRGQVKT---TGYPQTEGLLGDCMLKYG-KELGED---STFGNA---LIEVGESMKLMAEVKDSLDINVKQ T-FIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRV----------------------------------------- ------GKIPDEEVRQAVEKFEESKELAERSMFNFLENDV--EQVSQLAVFIEAALDYHRQSTEILQELQSKLQMR---I SAASSVPRREYKPR------------------PVKRS-------------------SSELNGVS---------------- ---------TTSVAKTTG----------------------------------------------SNIPMDQPCCRGLYDF EPEN-QGELGFKEGD---IITLTN--------------QIDENWYEG------------MIHGESG-----FFPINYVEV IVPLPQ--------------------------------- >Macaca_mulatta_SH3GL3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MLNTVSKIRGQVKA---TGYPQTEGLLGDCMLKYG-KELGED---STFGNA---LIEVGESMKLMAEVKDSLDINVKQ T-FIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRV----------------------------------------- ------GKIPDEEVRQAVEKFEESKELAERSMFNFLENDV--EQVSQLAVFIEAALDYHKQSTEILQELQSKLQMR---I SAASSVPRREYKPR------------------PVKRS-------------------ASELNGVS---------------- ---------TTSVVKTTG----------------------------------------------SNIPMDQPCCRGLYDF EPEN-QGELGFKEGD---IITLTN--------------QIDENWYEG------------MIHGESG-----FFPINYVEV IVPLPQ--------------------------------- >Mus_musculus_SH3GL3 ---------------------------------------------------------------------MSVAGLK---- KQFHKAS-QLFSEKISGAEGT-KLDEEFLNMEKK--------------IDIT----SKAVAEILSKATEYLQPNPAYRAK LGMLNTVSKLRGQVKA---TGYPQTEGLLGDCMLKYG-KELGED---SAFGNS---LVDVGEALKLMAEVKDSLDINVKQ T-FIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKRRV----------------------------------------- ------GKIPEEEIRQAVEKFEESKELAERSMFNFLENDV--EQVSQLAVFVEAALDYHRQSTEILQELQSKLELR---I SLASKVPKREFMPK------------------PVNMS-------------------STDANGVG---------------- ---------PSSSSKTPG----------------------------------------------TDTPSDQPCCRGLYDF EPEN-EGELGFKEGD---IITLTN--------------QIDENWYEG------------MLRGESG-----FFPINYVEV IVPLPP--------------------------------- >Canis_familiaris_SH3GL3 ---------------------------------------------------------------------VKKKKKK---- KRKEKKK-ELFSEKISGVEGT-KLDDEFLDMERK--------------IDIT----NKAVAEILSKATEYLQPNPAYRAK LGMLNTVSKIRGQVKT---TGYPQTEGLLGDCMLKYG-KELGEG---STFGNA---LIEVGESMKLMAEVKDSLDINVKQ T-FIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRV----------------------------------------- ------GKIPDEEVRQAVEKFEESKELAERSMFNFLENDV--EQVSQLAVFIEAALDYHKQSTEILQELQSKLQMR---I SAASSVPKREYKPR------------------PIKRS-------------------PNSGPSLHHYPLP----------- ---------TFSKVMWTG----------------------------------------------SNVAMDQPCCRGLYDF EPEN-QGELGFKEGD---VITLTN--------------QIDENWYEG------------MLHGESG-----FFPINYVEV IVPLP---------------------------------- >Xenopus_tropicalis_SH3GL3 ---------------------------------------------------------------------HGCKQLL---- TSLFVFL-QLFSEKISGAEGT-KLDDDFQEMERK--------------IDIT----NKVVAELLSKTTEYLQPNPAYRAR LGMLNTMSKIRGQVKT---TGYPQTEGLLGDCMLRHG-RELGDE---SEFGCA---LLDAGECMKQMAEVKDSLDINVKQ N-FIDPLQSLQDKDLKEILYHLKRLEGRRLDYDYKKRRQ----------------------------------------- ------GKIPDEEIRQAVEKFEESKELAERSMFNFLENDI--EQVSQLSVFVEAALDYHRQSAQILEDLHNRLHNR---M NTASSRPKRELQHK------------------SIIAT-LESNE-------------KLHHNGIP---------------- ---------SNSSIKPSGWK--------------------------SRAMQLNRVESEDTSGICSSGNLDQPCCRALYDF EPEN-EGELGFKEGD---IITLTN--------------QIDENWFEG------------MVNGESG-----FFPINYVEV VVPLP---------------------------------- >Danio_rerio_SH3GL3_a ---------------------------------------------------------------------MSVAGFK---- KQLHKAS-QLLSEKISGAEGT-KLDEDFMEMERK--------------IEVT----NKSVFELITKTTEYLQPNPASRAK LGMLNTVSKIRGQVKT---TGYPQTEGLLGDCMLRYG-RELGEE---SAFGTA---LADIGEAMKQMADIKDALDISVKQ N-FIDPLQNLQDKDLKEIVHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEEIKQAVEKFEESKELAERSMFNFLENDV--RHVSQRXALIEAALEYHRQSLEILKDLDSKLQNR---I STASRRPKKEFKPK------------------SIVSSLESVE--------------NTQHNGLS---------------- ---------HTSSIKSTE----------------------------------------------LESHMDQPCCRSLYDF EPEN-EGELGFKEGD---IIILTN--------------QIDENWYEG------------MINGESG-----FFPINYVDV LVPLPQ--------------------------------- >Tetraodon_nigroviridis_SH3GL3_a ---------------------------------------------------------------------MSVAGLK---- KQFHKAS-QLLSEKISGAEGT-RLEEDFVEMERK--------------IDVT----NKSIVELLSKTIEYLQPNPASRAK LNMLNTVSRIRGQVRT---NGYPQAEGLLGDCMLRYG-QELGED---SVFGGA---LVETGEGLRQMADVKDALDVSVKQ N-FIDPLQNLQDKELKEITHHLKKLEGRRLDFDYKKKRQ----------------------------------------- ------GKIPGDEIQQAAEKLEESKALAERSMFNFLESDM--EQVSQLASLIEAAKEYHRQSCKILEELFGKLQKR---I SSASFHPRKEFKPK------------------SIREAMTVFD--------------NSPHDSPS---------------- ---------RSASMKSSGP---------------------------------------------ASEVLDQPCCRSLYDF EPEN-EGELGFKEGD---VIILTN--------------QIDENWYEG------------MIHG-RA-----FFPISYVEV MVPLPQ--------------------------------- >Gasterosteus_aculeatus_SH3GL3_a -------------------------------------------------------------------------------- --------QLLSEKISGAEGT-KLDEDFMEMERK--------------IEVT----NKSVFDLLSKTTEYLQPNPASRAK LNMLNTVSKMRGQVSP---TGYPQTEGLLGDCMLRHG-HELGED---SVFGCA---LVEMGEAMRQMADVKDALDIGVKQ N-FIDPLQNVQDKDLKEITHHLKKMEGRRLDFDYKKKRQ----------------------------------------- ------GKIPDEEIRQAVEKFDESRELAERSMFNFLENDV--EQVRQLLALIQAAAEYHRQSRDILQELSGKLQKR---I STASSRPRRDFHQK------------------SIRSSMQPVD--------------SGQHNGLS---------------- ---------FSSSLRASG----------------------------------------------TGEPLDQPCCRSLYDF EPEN-EGELGFKEGD---VIILTN--------------RIDDNWYEG------------MISGESG-----FFPINYVEV LVPLP---------------------------------- >Homo_sapiens_SH3GLB1 ------------------------------------------------------MNIMDF-----------NVKKLAADA GTFLSRAVQFTEEKLGQAEKT-ELDAHLENLLSK--------------AECT----KIWTEKIMKQTEVLLQPNP----N ARIEEFVYEKLDRKA----PSRINNPELLGQYMIDAG-TEFGPG---TAYGNA---LIKCGETQKRIGTADRELIQTSAL N-FLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSQLNSARLEGDNIMVNFSYMLNFLHVKWL-- ------KSEQ--ELRITQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLG-----S FPSNYLSNNNQTSVTP---------------VPSVLPNAIGSS---------------AMAS-TS--------------- ----------GLVI-TS-----------------------------------------PSNLSDLKECSGSRKARVLYDY DAAN-STELSLLADE---VITVF------------SVVGMDSDWLMG------------ERGNQKG-----KVPITYLEL LN------------------------------------- >Pan_troglodytes_SH3GLB1 ------------------------------------------------------MNIMDF-----------NVKKLAADA GTFLSRAVQFTEEKLGQAEKT-ELDAHLENLLSK--------------AECT----KIWTEKIMKQTEVLLQPNP----N ARIEEFVYEKLDRKA----PSRINNPELLGQYMIDAG-TEFGPG---TAYGNA---LIKCGETQKRIGTADRELIQTSAL N-FLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSQLNSARLEGDNIMIWAEEVT---------- ------KSEQ--ELRITQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLG-----S FPSNYLSNNNQTSVTP---------------VPSVLPNAIGSS---------------AMAS-TS--------------- ----------GLVI-TS-----------------------------------------PSNLSDLKECSGTRKARVLYDY DAN--STELSLLAD----VITVF------------SVVGMDSDWLMG------------ERGNQKG-----KVPITYLEL LN------------------------------------- >Macaca_mulatta_SH3GLB1 ------------------------------------------------------MNIMDF-----------NVKKLAADA GTFLSRAVQFTEEKLGQAEKT-ELDAHLENLLSK--------------AECT----KIWTEKIMKQTEVLLQPNP----N ARIEEFVYEKLDRKA----PSRINNPELLGQYMIDAG-TEFGPG---TAYGNA---LIKCGETQKRIGTADRELIQTSAL N-FLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSQLNSARLEGDNIMIWAEEVT---------- ------KSEQ--ELRITQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLG-----S FPSNYLSNNNQTSVAP---------------VPSVLPNAIGSS---------------AMAS-TS--------------- ----------GLVI-TS-----------------------------------------PSNLSDLKECSGSRKARVLYDY DAAN-STELSLLADE---VITVF------------SVVGMDSDWLMG------------ERGNQKG-----KVPITYLEL LN------------------------------------- >Mus_musculus_SH3GLB1 ------------------------------------------------------MNIMDF-----------NVKKLAADA GTFLSRAVQFTEEKLGQAEKT-ELDAHLENLLSK--------------AECT----KIWTEKIMKQTEVLLQPNP----N ARIEEFVYEKLDRKA----PSRINNPELLGQYMIDAG-TEFGPG---TAYGNA---LIKCGETQKRIGTADRELIQTSAL N-FLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETKSSQLNSARPEGDNIMVNFSYMLNFLHVKWL-- ------KSEQ--ELRITQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLG-----S FPSNYLSNNNQTSGTP---------------VPYALSNAIGPS---------------AQAS-TG--------------- ----------SLVI-TC-----------------------------------------PSNLNDLKESSNNRKARVLYDY DAAN-STELSLLADE---VITVF------------SVVGMDSDWLMG------------ERGNQKG-----KVPITYLEL LN------------------------------------- >Canis_familiaris_SH3GLB1 -------------------------------------------------------------------------------- ---------------------------------------------------------------MKQTEVLLQPNP----N ARIEEFVYEKLDRKA----PSRINNPELLGQYMIDAG-TEFGPG---TAYGNA---LIKCGETQKRIGTADRELIQTSAL N-FLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETKAS------------------------------ -------SEQ--ELRITQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLG-----S FPSSY-CNNNQTSVAP---------------VPSASSNVIGSS---------------TLTS-TS--------------- ----------GLVI-AS-----------------------------------------PTNLNDLKECSGSRKARVLYDY DAAN-SSELSLLADE---VITVF------------SVVGMDSDWLMG------------ERGNQKG-----RVPITYLEL LN------------------------------------- >Myotis_lucifugus_SH3GLB1 ------------------------------------------------------MNMMDF-----------NVKKFAADA GTFLSRAVQFTEEKLGQAEKT-ELDAHLENLLSK--------------AECT----KIWTEKIMKQTEVLLQPNP----N ARIEEFVYEKLDRKA----PSRVNNPELLGQYMIDAG-TEFGPG---TAYGNA---LIKCGETQKRIGTADRELIQTAAL N-FLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRAS------------------------------ -------SEQ--ELRITQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLG-----S FPSSYHSNNNQTSVVP---------------VPSASSNVIGSS---------------AMTS--S--------------- ----------GLVM-TS-----------------------------------------PSNLIDLKEGSGSRKARVLYDY DAAN-SSELSLLADE---VITVF------------SVVGMDSDWLMG------------ERGNQKG-----RVPITYLEL LN------------------------------------- >Monodelphis_domestica_SH3GLB1 ------------------------------------------------------MSIMDF-----------NVKKLAADA GTFLSRAVQFTEEKLGQAEKT-ELDAHLENLLSK--------------AECT----KQWTEKMMRQTEVLLQPNP----N ARIEEFVYEKLDRKA----PTRINNQELLGQYMIDAG-NDFGPG---TAYGNA---LIKCGETQKRIGTADRELVQTAAI N-FLTPLRNFIEGDYKTITKERKLLQNKRLDLDAAKTRLKKAKIAETRALQLNSTQPEGDNIMVNLSYMLNLLHVKWLKI WAEEVTKSEQ--ELRITQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLG-----S FPSVFVSNNSQSSTTS---------------MSNISTS-SSGIT---------------TSLLPS--------------- ----------TSGT-AI-----------------------------------------TPAIGDLKESSGNRKARVLYDY DAAN-STELSLLADE---VITVY------------SIVGMDSDWLMG------------ERGNQKG-----KVPITYLEL LN------------------------------------- >Gallus_gallus_SH3GLB1 ------------------------------------------------------MNIMDF-----------NMKKLAADA GTFLSRAVQFTEEKLGQAEKT-ELDAHLENLLSK--------------AECT----KQWTEKIMKQTEVLLQPNP----N ARIEEFFYEKLDRKA----PSRMNNPELLGQYMIDAG-NEFGPG---TAYGNA---LIKCGETQKQIGTADRELIQTSAI N-FLTPLRNFIEGDYKTITKERKLLQNKRLDLDAAKTRLKKAKVAEARAA------------------------------ -------SEQ--EVRITQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYYAQCYKYMLDLQKQLG-----S FPSTFLSNNNQSSSAP---------------VQSVSTPSVLAS---------------ASASLPS--------------- ----------VSNS-VV-----------------------------------------TSGISELKSSSGSRKARVLYDY DAAN-SSELSLLADE---VITVY------------SIPGMDSDWLMG------------ERGNQKG-----KVPITYLEL LN------------------------------------- >Xenopus_tropicalis_SH3GLB1 --------------------------------------------------------AMDF-----------NVKKLAADA GTFLSRAVQFTEEKFGQAEKT-ELDAHLENLLSK--------------AECT----KVWTEKIMKQTEVLLQPNP----N ARIEEFVYEKLDRKA----PSRLNTEEQLAQYMTDAG-NEFGPG---TAYGNA---LIKCGETQKRIGVAHRELVQTAAI N-FLTPLRNFIEGDFKTMSKEKKLLQNKRLDLDAAKTRLKKARVTEARAA------------------------------ -------AEQ--ELRITQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYFAQSYQYMLDLQKQLG-----S FPSTFVSNNNQSTLTP---------------MQSVSVPSVSAS-----------------AQAPS--------------- ----------AKSS-LV-----------------------------------------TSGFTELKASNGSRKARVLYDY DAAN-SSELSLLADE---VITVY------------SMPGMDSDWLMG------------ERGHQKG-----KVPITYLEL LN------------------------------------- >Danio_rerio_SH3GLB1_a ---------------------------------------------------------MEF-----------NVRRLAADA GTFLSRAVQFTEEKFGQAEKT-ELDAHLEMLLSR--------------AEST----KHWTEKIMKQTEVVLQPNP----N VRVEEFLYEILDKKV----PTRANNHEMLGQCMIDSG-HEFGPG---TAYGSA---LIKCGETEKLLGSAEKEFIHSSAI N-FLTPFRNFIEGDFKTILKERKLLQNKRLDLDAAKNRMKKARVADARSAELNCSPPLGEEYVAHFSYMLSFLHVRWLKL WTEEVKQAET--ELRIAQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVDAQAAYYAQCYQYTVNLQKQLGS-QTAI FPSTFS-NNNQPSGSS---------------SASVCVPTAPPAA--------------SLPAPPP--------------- ----------SQ----A-----------------------------------------SPALNELRSSSGTRKARVLYDY DAAS-STELSLLADE---VITVS------------SVPGMDSDWLMG------------QRGNQKG-----KVPITYLEL LN------------------------------------- >Danio_rerio_SH3GLB1_b ---------------------------------------------------------MDF-----------NVKRFAADA GTLFSRAVQFTEEKFGQAEKT-ELDAHLETLLTR--------------AECT----KHWTEKILKQTEVLLQPNP----N ARIEELLYEKLDKKA----PPRMNNHELMGQSMIDSG-NEFGPG---TAYGNA---LIKCGETEKQIGGAEREFIQTSAI N-FLTPFRNFLEGDFKTILKERKLLQNKRLDLDAAKTKLKKAKMADARAV------------------------------ -------AEQ--DLKMTQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDFVEAQMTYYAQCYQYMVDLQKQLG-----N FPSAFTSNNNQSTASG---------------GAGVSVPILPLST--------------PLPSTTS--------------- ----------N-----T-----------------------------------------SSGFTEMQNFSGSRKARVLYDY DAAG-SNELSLLADE---VIMVS------------SVPGMDSDWLMG------------ERGSQKG-----KVPITYLEL LN------------------------------------- >Takifugu_rubripes_SH3GLB1_a --------------------------------------------------------TMDF-----------NVKRLAADA GTFLSRAVQFTEEKFGQAEKT-ELDAHLENLLVR--------------AENT----KLWTERIMKQTEVLLQPNP----N VRLEEFVYEKLEKKA----PTRMNNHELLGQTMIDSG-SEFGPG---TAYGNA---LMKCGETEKQIGGAEREFIHGAAI N-FLTPFRNFLEGDFKTILKERKLLQVKRLDLDAAKTRLKKARMADARAA------------------------------ -------AEQ--ELRMTQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDLVEAQTTYYAQCYQYMVDLQKQLG-----S FPSSFT-NNNQSAASG---------------GASASAPTIPVSA--------------SLPSAGG--------------- ----------G---STA-----------------------------------------SGGFNELRSSSASRRARVLYDY DAAS-SSELSLLADE---VITVS------------SVPGMDSDWLMG------------ERGNQKG-----KVPITYLEL LN------------------------------------- >Tetraodon_nigroviridis_SH3GLB1_a ------------------------------------------------------LFNMDF-----------NVKRLAADA GTFLSRAVQFTEEKFGQAERT-ELDAHLENLLVR--------------AEST----KVWTERIMKQTEVLLQPNPT---D VRLEEFVYEKLEKKA----PTRMNNHELLGQALMDSG-SECGPG---TAYGNA---LMKCGEAEKLIGGAEREFMQGAAI N-FLTPLRNFLEGDFKTILKERKLLQVRRLDLDAAKTRLKKARLAEARAA------------------------------ -------AEQ--ELRVTQSEFDRQAEITRLLLEGISSTHA--HHLRCLNDLVEAQSSYYAQCYQYMVDLQKQLG-----S FPSSFT-NNNQASVSG---------------GAGASAPTIAVSS--------------SLS------------------- ---------------------------------------------------------------ELRGSGASRRARVLYDY DAAS-SSELSLLADE---VITVS------------SVPGMDSDWLMG------------ERGNQKG-----KVPITYLEL LN------------------------------------- >Gasterosteus_aculeatus_SH3GLB1_b -----------------------------------------------------CGFAMDF-----------NVKRLAADA GTFLSRAVQFTEEKLGQAEKT-ELDAHLENLLVR--------------AENT----KQWTERIMKQTEVLLQPNP----N VRLEEFVYEKLEKKA----PTRLNNHDLLGQSMIESG-NEFGPG---TAYGNA---LIKCGETEKQIGGAERELIQSAAI N-FLTPFRNFLEGDFKTILKERKLLQVKRLDLDAAKTKLKKARMADARAAQGGMTPHV---------------------- ---ADPQAEQ--ELRMSQSEFDRQAEITRLLLEGVSSTHA--HHLRCLNDFVEAQTTYYAQCYQYMVDLQKQLG-----R YHPALG-RLPHQGCDS---------------EDRLSE------------------------------------------- ----------------------------------------------------------SGGFNELRGSNGSRRARVLYDY DAAS-SSELSLLADE---VDIVIVVS---------SVPGMDSDWLMG------------ERGTQKG-----KVPITYLEL LN------------------------------------- >Oryzias_latipes_SH3GLB1_a ---------------------------------------------------------MDF-----------NVKRFAADA GTFLSRAVQFTEEKLGQAEKT-ELDAHLENLLVR--------------AENT----KQWTEKIMKQTEVLLQPNP----N VRLEEFVYEKLEKKA----PTRMNNHELLGQSMIESG-SEFGPG---TAYGNA---LIKCGETQKQIGGAEREFIQSAAI N-FLTPFRNFLEGDFKTILKERKLLQVKRLDLDAAKTRLKKARMSDARAA------------------------------ -------AEQ--ELRMTQSEFDRQAEITRLLLEGVSSTHA--HHLRCLNDLVEAQTTYYAQCYQYMVDLQKQLG-----S FPSTFS-NNNQ--VSG---------------GASISVPTIPVSA--------------SLPSVSA--------------- ----------GQSSLSA-----------------------------------------SAGF------SGSRKARVLYDY DAAS-SSELSLLADE---AEQP------------CCVPGMAKKW------------------------------------ --------------------------------------- >Drosophila_melanogaster_SH3GLB1 ----------------------------------------------------MNINLPNF-----------NVKNLVKEA GSTISRVVQLTEEKLGTTERT-EYDLHFQNLAER--------------ADVT----KTWTEKIVRDTESVLIPNPQ---- NRVEDFIFEKIEKSK----PKRLSNLEHLALDMIEAG-GDFGQD---LPYGQA---LIKVGQAEQKLGQCEHDFIATSGI C-FTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSK-DGISPEAVLEQ----------------- -------AER--DLRVAQAEFDRQAEITKLLLDGISTSQA--SHLRHLHAFIQTQVRYYKQCGDVMEQLQRELA------ NLG--GPTPYIPLDVN---------------EASASKSNISSGAA------------ARGPGNNH--------------- ----------SANMAAT---------------------------------------GHKPNQPMHVSTDQMQRARVLCSY DAKD-HTELNLSAN---EVIFV------------TECSPVNEDYMYG------------KQGLLKG-----LVPRAFVEM LDEEHDVTL------------------------------ >Anopheles_gambiae_SH3GLB1 ----------------------------------------------------MNIKMPDF-----------DVKKFVKGA GSTLSRVVQLTEEKLGTSEKT-EMDARFEHLSER--------------SDSA----KLWTEKIMRDTEAALIPNPA---- NRVEDFIFEKIEKQK----PKRLSNLEYLGLDMIEGG-GEFGQD---GPYGSA---LIKVGQAEQKLGSCERDFIGSAGM C-FIQPLKKFLEGEMKTITKEKGVLESKRLDLDACKNRVRKARSMIGQQAK-DGISPEVTLEQ----------------- -------AER--DLRVAQSEFDRQAEITKLLLEGISTTQA--THLRYLHSLVEAQVRYYGQCNKIMSDLQRELL------ TTL--PTDHNITSRNP---------------DDIRAASSYLGGPQ------------PYVPVSGY--------------- ----------EDEDALS---------------------------------------ERVNNIELGANSG-YRRARVLCSY DAKD-GTELNLSSNEARAVIFV------------CECNPPHSDYMNG------------KQGLLKG-----LVPKAFLEM LDDD----------------------------------- >Homo_sapiens_SH3GLB2 ---------------------------------------------------------MDF-----------NMKKLASDA GIFFTRAVQFTEEKFGQAEKT-ELDAHFENLLAR--------------ADST----KNWTEKILRQTEVLLQPNPS---- ARVEEFLYEKLDRKV----PSRVTNGELLAQYMADAA-SELGPT---TPYGKT---LIKVAEAEKQLGAAERDFIHTASI S-FLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATCEGDTVPDFQETRPRNYILSASASALWNDE VDK----AEQ--ELRVAQTEFDRQAEVTRLLLEGISSTHV--NHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGSSQGAI FPGTFVGTTEPASP-----------------PLSSTSPTTAAATM------------PVVPSVAS--------------- ----------LAPPGEA----------------------------------------SLCLEEVAPPASGTRKARVLYDY EAAD-SSELALLADE---LITVY------------SLPGMDPDWLIG------------ERGNKKG-----KVPVTYLEL LS------------------------------------- >Pan_troglodytes_SH3GLB2 ---------------------------------------------------------MDF-----------NMKKLASDA GIFFTRAVQFTEEKFGQAEKT-ELDAHFENLLAR--------------ADST----KNWTEKILRQTEVLLQPNPS---- ARVEEFLYEKLDRKV----PSRVTNGELLAQYMADAA-SELGPT---TPYGKT---LIKVAEAEKQLGAAERDFIHTASI S-FLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKAT----TVPDFQETRPRNYILSASASALWNDE VDK----AEQ--ELRVAQTEFDRQAEVTRLLLEGISSTHV--NHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGSSQGAI FPGTFVGTTEPASP-----------------PLSSTSPTTAAATM------------PVVPSVAS--------------- ----------LAPPGEA----------------------------------------SLCLEEVAPPASGTRKARVLYDY EAAD-SSELALLADE---LITVY------------SLPGMDPDWLIG------------ERGNKKG-----KVPVTYLEL LS------------------------------------- >Macaca_mulatta_SH3GLB2 ---------------------------------------------------------MDF-----------NMKKLASDA GIFFTRAVQFTEEKFGQAEKT-ELDAHFENLLAR--------------ADST----KNWTEKILRQTEVLLQPNPS---- ARVEEFLYEKLDRKV----PSRVTNGELLAQYMADAA-SELGPT---TPYGKT---LIKVAEAEKQLGAAERDFIHTASI S-FLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATVDSGTVPDFQETRPRNYILSASASALWNDE VDK----AEQ--ELRVAQTEFDRQAEVTRLLLEGISSTHV--NHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGSSQGAI FPGTFVGTTEPASP-----------------PLSSTSPTTAAATM------------PVVPSVAS--------------- ----------LAPPGEA----------------------------------------SLCLEEVAPPASGTRKARVLYDY EAAD-SSELALLADE---LITVY------------SLPGMDPDWLIG------------ERGNKKG-----KVPVTYLEL LS------------------------------------- >Mus_musculus_SH3GLB2 ---------------------------------------------------------MDF-----------NMKKLASDA GIFFTRAVQFTEEKFGQAEKT-ELDAHFENLLAR--------------ADST----KNWTERILRQTEVLLQPNPS---- ARVEEFLYEKLDRKV----PSRVTNGELLAQYMAEAA-SELGPS---TPYGKT---LIKVSEAEKRLGAAERDFIHTASL S-FLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATCEGDTVPDFQETRPRNYILSASASALWNDE VDK----AEQ--ELRVAQTEFDRQAEVTRLLLEGISSTHV--NHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGSSQGAI FPGTFVGTTEPASP-----------------PLSSTSPTTTAATM------------PVVPTGAV--------------- ----------LAPPEEA----------------------------------------ALCLEEVAPPASGTRKARVLYDY EAAD-SSELALLADE---LITVY------------SLPGMDPDWLIG------------ERGNKKG-----KVPVTYLEL LS------------------------------------- >Canis_familiaris_SH3GLB2 ---------------------------------------------------------MDF-----------NMKKLASDA GIFFTRAVQFTEEKFGQAEKT-ELDAHFENLLAR--------------ADST----KNWTEKILRQTEVLLQPNPS---- ARVEEFLYEKLDRKV----PSRVTNGELLAQYMAEAA-SELGPT---TPYGKT---LIKVAEAEKRLGAAERDFIHTASI N-FLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATT----VPDFQETRPRNYILSASASALWNDE VDK----AEQ--ELRVAQTEFDRQAEVTRLLLEGISSTHV--NHLRCLHEFVESQTTYYAQCYRHMLDLQKQLGR----- FPGTFVGTTEPVSP-----------------PLSSTSPTTAVATM------------PVGPSVAG--------------- ----------LAPPGEA----------------------------------------ALRL-EVTPPASGTRKARVLYDY EAAD-SSELALLADE---LITVY------------SLPGMDPDWLIG------------ERGNKKG-----KVPVTYLEL LS------------------------------------- >Xenopus_tropicalis_SH3GLB2 ---------------------------------------------------------MDF-----------SVKKLASDA GVFFSRAVQFTQENLGQAEKT-ELDAHFENLLTR--------------ADNT----KNWTEKILRQTEVLLQPSPS---- ARVEEFLYEKLDRKI----PSRVTTAELLGQYMTEAA-NDFGPS---TPYGQT---LIKVGETQKHLGTAERDFIHSSSI N-FLTPLRNFLEGDWKTISKERRILQNRRLDLDACKARLKKAKAAEAKAA----ALPDFQETRPRNYILSASASAMYCER LNYS---AEH--ELRVAQTEFDRQAEVTRLLLEGISSTHV--NHLRCLHEFAEAQATYFAQSYQYMVDLQKQLGR----- FPAPVVGNTDPASP-----------------PLSTSPPPATLPVL------------QVASSNPG--------------- ----------EVP---------------------------------------------LNPVEVPPPVSGTRKARVLYDY EAAD-SKELSLSADE---LITVY------------SLPGLDPDWLIG------------ERGNKKG-----KVPVTYLEL LS------------------------------------- >Danio_rerio_SH3GLB2_a ---------------------------------------------------------MDF-----------NVKKLASDA GVFFTRAVQYTEEKLGQAEKT-ELDAHLENLIAR--------------ADCT----KNWTEKIFRQTEVLLQPNPS---- ARIEEFFYEKLDKKI----PSRITNAELLGQYMQDAA-KDFGPG---SPYGST---LITVGEYQKRLGGSEREFLQTSAI N-FLTPLRNFLEGDWKTISRERRLLENRRLDLDVCKARLKKAKLAEAKAA----AAPDFQETRPRNYVLSASASALWSEE VDK----AEH--ELRVAQTEFDRQAEVTRLLLEGISSTHV--NHLRCLHEFVEAQAAYYAQCHRHMQDLQKELSSANGDT FPNAFAVNASTSGVSA---------------GPSPLSTGTQPGPS------------SPSRPPNP--------------- ----------PNALESN----------------------------------------TLKIEEVKPPATGTRKAKVLYDY DAAD-TSELSLLADE---LITVY------------TVPGMDPDWLIG------------ERGNQKG-----KVPVTYLEL LS------------------------------------- >Takifugu_rubripes_SH3GLB2_a ---------------------------------------------------------MDF-----------NVKKLASDA GVFFTRAVQFTEEKLGQAEKT-ELDPHLENLISR--------------ADAT----KNWTEKMLRQTEALLQPNPS---- TRIEEFIYDKLDKKL----PSKVTNAELLGQYMLDAA-NDLGPG---TPYGST---LITVGEYQKRLGGAEREFLHIATA N-FLSPLRNFLEGDWRTISKERRLLENRRLDLDICKARLKKAKQAEAKAA----AAPDFQETRPRNYVLSASASALLSEE VDK----AEH--ELRVAQTEFDRQAEVTRLLLEGISSTHL--NHLRCLHDFAEAQATYYAQCHHYMQDLQRELSRSGSST GGHMDLDSSDVEGNN-------------------GLSLTGA--IM------------LLGPLLRL--------------- ----------LGAPTHG----------------------------------------TLTVEQLP--VTGTRKAKVLYDY DAHD-ASELSLLADE---LITVY------------TLPGMDPDWLIG------------ERGNNKG-----KVPVTYLEL LS------------------------------------- >Tetraodon_nigroviridis_SH3GLB2_a ---------------------------------------------------------MDF-----------NMKKLASDA GLFFTRAVQFTEEKLGQAEKT-ELDPHLENLLAR--------------ADAT----KNWTEKVLRQTEALLQPNPS---- ARIEEFIYDKLDRKL----PSKVTNAELLGQHMLDAA-ADLGPE---TPYGST---LTTVGEYQKRLGGAEREFLYIATA N-FLTPLRNFLEGDWRTISKERRLLENRRLDLDICKARVKKAKQAEAKAA----AAPDFQETRPRNYVLSASASALLSEE VDK----VRRSRELRVAQTEFDRQAEVTRLLLEGISSTHL--NHLRCLHDFAEAQASYYAQCHHYTQELQRELSRRRRRK ASAAPAADSSP-----------------------CLFPHRCANPA------------AAAPKPSA--------------- ----------AASSSHS----------------------------------------ALGVEQTPLAVTGTRKAKVLYDY DAHD-ASELSLLADE---LITVY------------TVPGMDPDWLVG------------ERGNDKG-----KVPVTYLEL LS------------------------------------- >Gasterosteus_aculeatus_SH3GLB2_b ---------------------------------------------------------MDF-----------NVKKLACGA GVFFTRAVQFTEEKLGQAEKT-ELDPHLENLITR--------------ADST----KNWTEKILRQTEVLLQPNPS---- ARIEEFIYDKLDKKL----PSRTTNTELLGQYMLEAA-NEFGPG---TPYGST---LITVGEYQKRLGGAERDLLQASAV G-FLTPLRNFLEGDWRTISKERRLLENRRLDLDICKARLKKAKLAEAKAA----AAPDFQETRPRNYVLSASASALLSEE ADK----AEH--ELRVAQAEFDRQAEVTKLLLEGIGSTHL--NHLRCLQDFAEAQATYYAQCHHHMQDLQRELS----ST PHSAPVVCPDP--------------------------VSSAFLSG------------PPSPGASV--------------- ----------SSLSSQR----------------------------------------PLAMEQTQLPVTGTRKAKVLYDY EGHD-GTELSLLADE---LITVH------------TVPGMDPDWLIG------------ERGNQKG-----KVPVTYLEL LS-------------------------------------