>Homo_sapiens_CLIC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAEE-QPQVELFVK----AGSDG------------------AKIGNCPFSQR LFMVL---WLKGVTFN--VTTVDTKRRTETVQKLCPGGQLPFLLYGTEV--------HTDTNKIEEFLEAVLCPPRYPKL AALNPESNTAG--LDIFAKFSAYIKNS--NPALN----DNLEKGLLKALKVLDNYLTSPLPEEVDETS-AEDEGVSQRKF LDGNELTLADCNLLPKLHIVQ--VVCKKYRGFTIP-EAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVA------- ------KALK---------------------------- >Pan_troglodytes_CLIC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAEE-QPQVELFVK----AGSDG------------------AKIGNCPFSQR LFMVL---WLKGVTFN--VTTVDTKRRTETVQKLCPGGQLPFLLYGTEV--------HTDTNKIEEFLEAVLCPPRYPKL AALNPESNTAG--LDIFAKFSAYIKNS--NPALN----DNLEKGLLKALKVLDNYLTSPLPEEVDETS-AEDEGVSQRKF LDGNELTLADCNLLPKLHIVQ--VVCKKYRGFTIP-EAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVA------- ------KALK---------------------------- >Callithrix_jacchus_CLIC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAEE-QPPVELFVK----AGSDG------------------AKIGNCPFSQR LFMVL---WLKGVTFN--VTTVDTKRRTETVQKLCPGGQLPFLLYGTEV--------HTDTNKIEEFLEAVLCPPRYPKL AALNPESNTAG--LDIFAKFSAYIKNS--NPALN----DNLEKGLLKALKVLDNYLTSPLPEEVDETS-AEDEGISQRKF LDGNELTLADCNLLPKLHIVQ--VVCKKYRGFTIP-EAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVA------- ------KALK---------------------------- >Mus_musculus_CLIC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAEE-QPQVELFVK----AGSDG------------------AKIGNCPFSQR LFMVL---WLKGVTFN--VTTVDTKRRTETVQKLCPGGQLPFLLYGTEV--------HTDTNKIEEFLEAMLCPPRYPKL AALNPESNTSG--LDIFAKFSAYIKNS--NPALN----DNLEKGLLKALKVLDNYLTSPLPEEVDETS-AEDEGISQRKF LDGNELTLADCNLLPKLHIVQ--VVCKKYRGFTIP-EAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVA------- ------RALK---------------------------- >Bos_taurus_CLIC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAEE-QPQVELFVK----AGSDG------------------AKIGNCPFSQR LFMVL---WLKGVTFN--VTTVDTKRRTETVQKLCPGGQLPFLLYGTEV--------HTDTNKIEEFLEAVLCPPRYPKL AALNPESNTAG--LDIFAKFSAYIKNS--NPALN----DNLEKGLLKALKVLDNYLTSPLPDEVDETS-AEDEGISQRKF LDGNELTLADCNLLPKLHIVQ--VVCKKYRGFSIP-DVFRGVHRYLRNAYAREEFASTCPDDEEIELAYEQVA------- ------KALK---------------------------- >Myotis_lucifugus_CLIC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------LDLT-EPRVEYPVL----AGSDGG-----------------AKIGNCPFSQR LFMVL---WLKGVTFN--VTTVDTKRRTETVQKLCPGGQLPFLLYGTEV--------HTDTNKIEEFLEAVLCPPRYPKL AALNPESNTAG--LDIFAKLIGLCQSF--DALANALSCADLEKGLLKALKVLDNYLASPLPEEVDETS-AEDEGISQRKF LDGNELTLADCNLLPKLHIVQ--VVCKKYRGFSIP-EAFRGVHRYLRNAYAREEFASTCPDDEEIELAYEQVA------- ------KALK---------------------------- >Anolis_carolinensis_CLIC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------IRPE-SPSGQRIIK----AGSDG------------------AKIGNCPFSQR LFMVL---WLKGVTFN--VTTVDTKRRTETVQKLCPGGQLPFLMYGTEV--------HTDTNKIEEFLEEVLCPPKYPKL AARNPESNTAG--LDVFAKYSAYIKNS--NPALN----ANLEKGLLKALKVLDMYLMAPLPEEVDENS-AEDEGQSSRKF LDGDELTLADCNLLPKLHIVK--VVCKKYRNFTIP-EEFCGIHRYLKNAYAREEFASTCPDDEEIELAYELVA------- ------KALK---------------------------- >Danio_rerio_CLIC1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MSEE-RPEVELFVK----AGSDG------------------QSIGNCPFSQR LFMVL---WLKGVTFN--VTTVDMKRKPEILKDLAPGAQPPFLLYGTEV--------KTDTNKIEEFLEETLCPPKYPRL AACNPESNTAG--LDVFSKFSAYIKNS--NPQMN----DNLEKGLLKALKKLDDYLSSPLPDEIDENS-ADDVISSTRSF LDGQELTLADCNLLPKLHIVK--VVCLKFRGFSIP-RSLTSLWRYLDAAYAREEFSSTCPSDEEIYVAYSSVV------- ------KALK---------------------------- >Takifugu_rubripes_CLIC1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------RQQQVKMSDATQPKIELFVK----AGSDG------------------QSIGNCPFSQR LFMVL---WLKGVTFD--VTTVDMKRKPEILKDLAPGAQPPFLLCGSEV--------KTDTNKIEEFLEEKLCPPKYPRL AARNPESNTAG--VDVFSKFSAYIKNS--NPQTN----ETLEKGLLKALKKLDDYLGTPLPDEVDQNS-SDDIISSARPF LDGQELTLADCNLLPKLHIVK--VVCLKYRSFNIP-QSLTNLWRYLNAAYAREEFSSTCPVDEEIHIAYSSVA------- ------KALK---------------------------- >Tetraodon_nigroviridis_CLIC1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MSDANQPKIELFVK----AGSDG------------------QSIGNCPFSQR LFMVL---WLKGVTFD--VTTVDMKRKPDILKDLAPGAQPPFLLYGSEV--------KTDTNKIEEFLEEKLCPPKYPRL AARNPESNTAG--VDVFSKFSAYIKNS--NPQAN----ENLEKGLLKALMKLDDYLGTPHPDEIDENS-SDDVVSSTRPF LDGPELTLADCNLLPKLHIVK--VVCLKYRSFTIP-QSLTNLWRYLNAAYAREEFSSTCPIDEEIHIAYSSVA------- ------KALK---------------------------- >Oryzias_latipes_CLIC1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------MVFLSLGIPGTMSDANQPKLELFVK----AGSDG------------------QSIGNCPFSQR LFMVL---WLKGVTFD--VTTVDMKRKPDILKDLAPGAQPPFLLFGSEV--------KTDTNKIEEFLEETLSPPKYPRL AARNPESNTAG--LDVFSKFSAYIKNS--NPQAN----ENLEKGLLKALKKLDDYLGSPLPDEVDENS-ADEVTSSSRPF LDGQNLTLADCNLLPKLHIVK--VVCLKYRNFSIP-DSLTNLWRYLNAAYAKDEFSSTCPVDEEIHSAYSSVA------- ------KALNK--------------------------- >Homo_sapiens_CLIC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MSGLRPGTQVDPEIELFV----KAGSD------------------GESIGNCPFCQR LFMIL---WLKGVKFN--VTTVDMTRKPEELKDLAPGTNPPFLVYNKEL--------KTDFIKIEEFLEQTLAPPRYPHL SPKYKESFDVG--CNLFAKFSAYIKNTQKEANKN------FEKSLLKEFKRLDDYLNTPLLDEIDPDS-AEEPPVSRRLF LDGDQLTLADCSLLPKLNIIK--VAAKKYRDFDIP-AEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYANVA------- ------KQKS---------------------------- >Pan_troglodytes_CLIC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MSGLRPGTQVDPEIELFV----KAGSD------------------GESIGNCPFCQR LFMIL---WLKGVKFN--VTTVDMTRKPEELKDLAPGTNPPFLVYNKEL--------KTDFIKIEEFLEQTLAPPRYPHL SPKYKESFDVG--CNLFAKFSAYIKNTQKEANKN------FEKSLLKEFKRLDDYLNTPLLDEIDPDS-AEEPPVSRRLF LDGDQLTLADCSLLPKLNIIK--VAAKKYRDFDIP-AEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYANVA------- ------KQKS---------------------------- >Macaca_mulatta_CLIC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MSGLRPSTQVDPEIELFV----KAGSD------------------GESIGNCPFCQR LFMIL---WLKGVKFN--VTTVDMTRKPEELKDLAPGTNPPFLVYNKEL--------KTDFIKIEEFLEQTLAPPRYPHL SPKYKESFDVG--CNLFAKFSAYIKNTQKEANKN------FEKSLLKEFKRLDDYLNTPLLDEIDPDS-AEEPTVSRRLF LDGDQLTLADCSLLPKLNIIK--VAAKKYRDFDIP-AEFSGVWRYLHNAYAREEFTYTCPEDKEIENTYASVA------- ------KQKS---------------------------- >Rattus_norvegicus_CLIC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MASLALNTQADPEIELFV----KAGSD------------------GESIGNCPFCQR LFMIL---WLKGVKFN--VTTIDTARKPEELKDLAPGTNPPFLIYNKEL--------KTDFIKIEEFLEKTLAPPRYPHL SPKYKESFDVG--CNLFAKFSAYIKNTQKEANKN------FEKSLLREFKRLDDYLNTPLLDEIDPDS-TEERTLSRRLF LDGDQLTLADCSLLPKLNIIK--VAAKKYRDFDIP-AEFSGVWRYLHNAYAREEFAHTCPEDKEIENTYASVA------- ------KQ------------------------------ >Bos_taurus_CLIC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MAGPRPSSEADPEIELFV----KAGSD------------------GESIGNCPFSQR LFMIL---WLKGVKFN--VTTVDMTRKPKELKDLAPGTNPPFLVYNKEL--------KTDFIKIEEFLEQTLAPPRYPHL SPRNKESFDVG--CNLFAKFSAYIKNTQKEANKT------FEKSLLKEFKRLDDYLNTPLLDEIDPDS-TEELTVSRRLF LDGDQLTLADCSLLPKLHIIK--VAAKKYRDFDIP-VEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYASVA------- ------KQKS---------------------------- >Myotis_lucifugus_CLIC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MAGLRPNIQADPEIELFV----KAGSD------------------GESIGNCPFCQR LFMIL---WLKGVKFN--VTTVDMTRKPEELKDLAPGANPPFLLYNKEL--------KTDFIKIEEFLEQTLAPPRYPCL SPKNKESFDVG--SNLFAKFSAYIKNTQKEANKN------FERALLREFKRLDDYLNTPLLDEIDPDS-TEELSVSRRLF LDGDDLTLADCSLLPKLNIIK--IAAKKYRDFDIP-AEFSGVWRYLHNAYAREEFAHTCPEDKEIEHTYASVA------- ------KQ------------------------------ >Monodelphis_domestica_CLIC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MADWGPTAKQEPEIELFV----RAGID------------------GESIGNCPFCHR LFMVL---WLKGVKFN--VTTVDMTRKPIELKELAPGTNPPFLLFNKEL--------KTDFIKIEEFLEQVLAPPRYPRL SPKYPESFDVG--CDIFAKFSAYIKNTQ-DTNKH------LEKALLKEFKRLDIYLNTPLPEEIDQDS-AEETVGSRRMF LDGDQLTLADCNLLPKLHIIK--VVAKKYRDFDIP-AEFSGVWRYLGNAYAREEFRHTCPADKEIESTYASVA------- ------KK------------------------------ >Danio_rerio_CLIC2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------MALRPDSDKEPRIELFI----KAGHD------------------GENVGNCPFCQR LFMVL---WLKGVKFT--VTTVDMRKKPDELKDLAPGTNPPFLLYNGTL--------KTDFIKIEEFLETTLAPPRYPHL SPRYKESFDVG--ADIFAKFSAFIKNSPNNAFH--------EKALLREFKRLDDYLNTPLQDELDQN-----ISVSKRKF LDGNRLTLADCNLLPKLHVIK--VAARKYCNFDIP-TQFTGVWRYLQSAYEREEFSQTCPADIEIEKAYLSVV------- ------KRN----------------------------- >Takifugu_rubripes_CLIC2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------HRQNSDREPHIELFI----KAGHD------------------GENVGNCPFCQR LFMVL---WLKGVKFT--VTTVDMRKKPAELKDLAPGTNPPFLLYNGAL--------KTDFIKIEEFLEQALAPPRYPHL SPLNKESFDVG--ADIFAKFSAFIKNSPNNAMTS------LEKNLLREFKRLDDYLNSPLPEEIDHNS-TETISVSKRKF LDGDRLTLADCNLLPKLHVIR--VAAKKYCNFEIP-AHFTGVWRYLENADGRDEFSQTCPADIEIEKAYLSVA------- ------SIRK---------------------------- >Gasterosteus_aculeatus_CLIC2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MKRSEFNFLGDDMALRQDSEKEPSVELFI----KAGHD------------------GENVGNCPFCQR LFMVL---WLKGVKFT--VTTVDMRKKPAELKDLAPGTNPPFLLYNGTL--------KTDFIKIEEFLEQTLAPPRYPHL SPLSKESFDVG--ADIFAKFSAFIKNSPNNTFH--------EKNLLREFKRLDIYLNSPLPEEIDLNS-RETITVSKRKF LDGDRLTLADCNLLPKLHVIR--IASKKYCDFDIP-AEFTGVWRYLQNAYQREEFKQTCPADIEIEKTYFTVA------- ------NKTSK--------------------------- >Oryzias_latipes_CLIC2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------LTLEKPNYSFQQNSEKEPIIELFV----KAGHD------------------GENVGNCPFCQR LFMVL---WLKGVKFT--VTTVDMRKKPAELKDLAPGTNPPFLLYNGTL--------KTDFIKIEEFLEQTLAPPRYPHL SPQNKESFDVG--ADIFAKFSAFIKNSPNNAVQ--------KKNLLKEFKRLDDYLNSPLPEEIDHHS-TETISTSNRKF LDGNRLTLADCNLLPKLHVIM--VASKKYCDFDIP-AHFTGVWRYLQNASEREEFVQTCPADIEIEKAYFSVA------- ------NNRK---------------------------- >Apis_mellifera_CLIC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------MADDSHENGTS-NGD----VPEIELIIK---ASTID------------------GRRKGACLFCQE YFMDLYL-LAELKTISLKVTTVDMQKPPPDFRTNFQATPPPILID--NGDAI------LENEKIERHIMKNIPG-GHNLF VQDKEVATLVE---NLFSKLKLLLLNA-KDKDKDP-----KS---------------SSLMAHLRKID--EHLGRKGTRF LTGDTMCCFDCELMPRLQHIR--VAGKYFADFEIP-ETLVHLWRYMHHMYRLDAFLQSCPADQDIINHYKLQQ------S MKMKKHEELETPTFTTSIPIEVNDD------------- >Homo_sapiens_CLIC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAET---KLQLFVK----ASED------------------GESVGHCPSCQR LFMVL---LLKGVPFT--LTTVDTRRSPDVLKDFAPGSQLPILLYDSDA--------KTDTLQIEDFLEETLGPPDFPSL APRYRESNTAG--NDVFHKFSAFIKNP--VPAQD----EALYQQLLRALARLDSYLRAPLEHELAGEP---QLRESRRRF LDGDRLTLADCSLLPKLHIVD--TVCAHFRQAPIP-AELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAV------- ------HPR----------------------------- >Pan_troglodytes_CLIC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAET---KLQLFVK----ASED------------------GESVGHCPSCQR LFMVL---LLKGVPFT--LTTVDTRRSPDVLKDFAPGSQLPILLYDSDA--------KTDTLQIEDFLEETLGPPDFPSL APRYRESNTAG--NDVFHKFSAFIKNP--VPAQD----EALYQQLLRALARLDSYLRAPLEHELAGEP---QLRESRRRF LDGDRLTLADCSLLPKLHIVD--TVCAHFRQAPIP-AELRGVRRYLDSALQEKEFKYTCPHSAEILAAYRPAV------- ------HPR----------------------------- >Macaca_mulatta_CLIC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAET---KLQLFVK----ASED------------------GE-VGHCPSCQR LFMVL---LLKGVPFT--LTTVDTR-SPDVLKDFAPGSQLPILLYDSDA--------KTDTLQIEDFLEETLGPPDFPSL APRYRESNTAG--NDVFHKFSAFIKNP--VPAQD----EALYQQLLRALARLDSYLRAPLEHELALEP---QLRESRRRF LDGDRLTLADCSLLPKLHIVD--TVCAHFRQAPIP-AGLPGVRRYLDSALQEKEFKYTCPHSAEILAAYRPAV------- ------HPR----------------------------- >Mus_musculus_CLIC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAETT--KLQLFVK----ASED------------------GESVGHCPSCQR LFMVL---LLKGVPFT--LTTVDTRRALDVLKDFAPGSQLPILLYDGDV--------KTDTLQIEEFLEETLGPPDFPSL APRYRESNTAG--NDIFHKFSAFIKNP--VPTQD----NALYQQLLRALTRLDSYLRAPLDHELAQEP---HLRESHRRF LDGDQFTLADCSLLPKLHIVD--TVCAHFRQLPIP-AELSCVRRYLDSALQKKEFKYTCPHSAEILAAYQPAV------- ------HPR----------------------------- >Canis_familiaris_CLIC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAETA--KLQLFVK----ASED------------------GESVGHCPSCQR LFMLL---LLKGVPFT--LTTVDTRRSLDVLKDFAPGSQLPILLYDGDA--------KTDTLQIEEFLEETLGPPEFPSL APRYRESTTAG--NDVFHRFSVFIKNP--VPAQD----NALYQLLLRALTRLDGYLRRPLEHELAQEP---QLQESRRRF LDGDQLTLADCSLLPKLYIMD--TVCTHFRQVPIP-AELCGVRRYLESALQVKEFKYTCPCSAEILAAYRMAV------- ------HPRYPLPTADRHPVCFSTAP------------ >Pteropus_vampyrus_CLIC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAETA--KLQLFVK----ASED------------------CESVGHCPSCQR LFMIL---LLKGVPFT--LTTVDTRRSPDVLKDFAPGSQLPILLYDGDA--------KTDTLQIEEFLEETLGPPEFPSL APRYKESAMAG--SDVFHKFSAFIKNP--APEQD----DALYQLLLRALARLDSYLRAPLEHELVREP---QLRESRRRF LDGDQLTLADCGLLPKLHIVD--TVCAHFRQAPIP-AQLRGVRRYLDGALQEKEFKYTCPHSAEILAAYRPAV------- ------RPR----------------------------- >Monodelphis_domestica_CLIC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAENP--KLQLFVK----ASED------------------GESVGNCPFCQR LFMIL---LLKGVPFT--LTTVDTKRSLDVLKDFAPGSQLPILLYDGEA--------KTDNIQIEEFLEEILGPPKYPSL VPRYKESNMAG--NDVFHKFSAFIKNT--SPSQD----EAFYRPLLRALVKLDHYLNTPLEHELIRDP---KLTQSRRHF LDGDQLTLADCNLLPKLHIIN--TVCTYYRQAPIP-AELQGLHRYLENALQVKEFKYTCPHSSEILAAYAPVA------- ------RAHPPPHGIHPSVRP----------------- >Gallus_gallus_CLIC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------GTGTRCTVTAQPPPSMDEKP--QIQLFVK----ASED------------------GESVGHCPFCQR LFMVL---LLKGAPFT--LTTVDTKRALDVLKDFAPGAQLPVLLYNGDS--------KTDTVTIEDFLEARLAPPTFPSL VPRYKESRLAG--NDIFHKFSTFIKNP--VPAQD----EALQRNLLKALLKLDEYLSTPLEHELAREP---HLRTSQRRF LDGDQLTLADCNLLPKLNIVQ--IVCQHYRRFGIP-KDLQAVWRYLNNAAETKEFKYTCPSSEEIVQAYRSVV------- ------RSPQ---------------------------- >Danio_rerio_CLIC3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAEAA--KIELFVK----ASDD------------------GESVGNCPFCQR LFMIL---WLKGVNFT--LTTVDMKRAPEVLKDLAPGSQPPFLIYNGEV--------RTDTNKIEEFLEDTLAPPQYPKL CCRYKESNTAG--DDIFHKFSAYIKNP--NPGLN----DMLEKKFLKSLMKLDQYLLTPLPHELDQNP---ELSTSTRHY LDGNALSLADCNLLPKLHIVK--VVCKKYRGFEIP-AELKGLSKYLDKAYKEDVFHLTCPKDKEILLAYSSVA------- ------KYLNK--------------------------- >Gasterosteus_aculeatus_CLIC3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------INQDYKTAGIKMSEVP--NIELFVK----ASVD------------------ADSVGNCPFSQR LFMIL---WLKGIKFR--LTTVDMKRAPDVLKTLAPGSQPPFLLYNEEV--------KTDTNKIEEFLEEKLAPPEYPKL CCRYKESIGAG--DDIFRNFSAYVKNP--NPAFN----ERIEKKFLSTLVKLNMYLETPLPYELDQKP---NATESSRLY LDGDTLTLADCNLLPKLNIVK--VVCKQYRDFDIP-KELRGLTRYLSNAYKRDEFRHTCPRDSEILIAYQAVA------- ------KYLNK--------------------------- >Oryzias_latipes_CLIC3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MSKQHPADNREEKKGMGDEP--NIELFVK----ASLD------------------AESVGNCPFCQR LFMIL---WLKRAEFV--LTTVDMKRAPEVLKALAPGSQPPFLIFNGEV--------KTDTNKIEEFLEEKLAPPRYPKL CCTYKESNLAG--EDIFRKFSAYIKNP--NPGLN----IMLEKQFLSTLVKLNMYLETPLPHELERNP---DANESSRLY LDGNAFTLADCNLLPKLNIVK--VVCKKYRNFDIP-TELKGLTRYLDNAYKQDEFRHTCPQDEEILLAYKSVA------- ------KYLTS--------------------------- >Nematostella_vectensis_CLIC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAEETIPGVELFVK---ASTLD------------------CQSLGADIQCHR IMMMF---ALKGLPIK--TFNVDTIKKTNVQLHFPYKNFPTLTLDNGAEVLDD---LDEIERRFEKLSETNQSIPKLACT NKDILSFVNVGPGSKIYQKFNYFIKNR--AQEGE----EALKTQLLQELKKVNAFLMSAKMPKDGEGN---------QMF LSGESPGLPDCTLLPKLHYIY--VCLGVVKEFPME--ELTGIESYLESGRKHSAFQSTCPKKADIVHFYCRQAGM----- ---DDAEAMRKSNQVRE--------------------- >Homo_sapiens_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MALSMPLNGLKEEDK----- -------------------------------------------------------------------------------- ---------------------------------EPLIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFS--VTTVDLKRKPADLQNLAPGTHPPFITFNSEV--------KTDVNKIEEFLEEVLCPPKYLKL SPKHPESNTAG--MDIFAKFSAYIKNS--RPEAN----EALERGLLKTLQKLDEYLNSPLPDEIDENS-MEDIKFSTRKF LDGNEMTLADCNLLPKLHIVK--VVAKKYRNFDIP-KEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVA------- ------KRLTK--------------------------- >Pan_troglodytes_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MALSMPLNGLKEEDK----- -------------------------------------------------------------------------------- ---------------------------------EPLIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFS--VTTVDLKRKPADLQNLAPGTHPPFITFNSEV--------KTDVNKIEEFLEEVLCPPKYLKL SPKHPESNTAG--MDIFAKFSAYIKNS--RPEAN----EALERGLLKTLQKLDEYLNSPLPDEIDENS-MEDIKFSTRKF LDGNEMTLADCNLLPKLHIVK--VVAKKYRNFDIP-KEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVA------- ------KRLTK--------------------------- >Callithrix_jacchus_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MALSMPLNGLKEEDK----- -------------------------------------------------------------------------------- ---------------------------------EPLIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFS--VTTVDLKRKPADLQNLAPGTHPPFITFNSEV--------KTDVNKIEEFLEEVLCPPKYLKL SPKHPESNTAG--MDIFAKFSAYIKNS--RPEAN----EALERGLLKTLQKLDEYLNSPLPDEIDENS-MEDIKFSTRKF LDGNEMTLADCNLLPKLHIVK--VVAKKYRNFDIP-KEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVA------- ------KRLTK--------------------------- >Mus_musculus_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MALSMPLNGLKEEDK----- -------------------------------------------------------------------------------- ---------------------------------EPLIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFS--VTTVDLKRKPADLQNLAPGTHPPFITFNSEV--------KTDVNKIEEFLEEVLCPPKYLKL SPKHPESNTAG--MDIFAKFSAYIKNS--RPEAN----EALERGLLKTLQKLDEYLNSPLPDEIDENS-MEDIKFSTRRF LDGDEMTLADCNLLPKLHIVK--VVAKKYRNFDIP-KGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVA------- ------KRLTK--------------------------- >Rattus_norvegicus_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MALSMPLNGLKEEDK----- -------------------------------------------------------------------------------- ---------------------------------EPLIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFS--VTTVDLKRKPADLQNLAPGTHPPFITFNSEV--------KTDVNKIEEFLEEVLCPPKYLKL SPKHPESNTAG--MDIFAKFSAYIKNS--RPEAN----EALERGLLKTLQKLDEYLNSPLPDEIDENS-MEDIKSSTRRF LDGDEMTLADCNLLPKLHIVK--VVAKKYRNFDIP-KGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVA------- ------KRLTK--------------------------- >Loxodonta_africana_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------VLEQPLPAERKEAK----- -------------------------------------------------------------------------------- ---------------------------------ERLNTSVPQ----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFS--VTTVDLKRKPADLQNLAPGTHPPFITYNNEV--------RTDVNKIEEFLEEVLCPPKYLKL SPKHPESNTAG--MDIFAKFSAYIKNS--RPEAN----EALERGLLKTLQKLDEYLNSPLPDEIDENS-MEDIKFSTRKF LDGNEMTLADCNLLPKLHIVK--VVAKKYRNFDIP-KEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVA------- ------KRLTK--------------------------- >Pteropus_vampyrus_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MALSMPLNGLKEEDK----- -------------------------------------------------------------------------------- ---------------------------------EPIIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFS--VTTVDLKRKPVDLQNLAPGTHPPFITFNNEV--------KTDVNKIEEFLEEVLCPPKYLKL SPKHPESNTAG--MDIFAKFSAYIKNS--RPEAN----EALERGLLKTLQKLDEYLNSPLPDEIDENS-MEDIKFSTRKF LDGNEMTLADCNLLPKLHIVK--VVAKKYRNFDIP-KGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVA------- ------KRLTK--------------------------- >Pelodiscus_sinensis_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MLMSCSLSQ----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFS--VTTVDLKRKPADLQNLAPGTHPPFITYNGEV--------KTDVNKIEEFLEDVLCPPKYLKL SPRHPESNTAG--MDIFAKFSAFIKNS--RPEAN----EALERSLLKTLQKLDEYLNTPLPDEIDENS-MEDIAVSTRKF LDGNEMTLADCNLLPKLHIVK--VVAKKYRNFDIP-KDMTGIWRYLTNAYSRDEFTNTCPGDKEIEIAYSDVA------- ------KRLTN--------------------------- >Takifugu_rubripes_CLIC4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MSLSVPQNGVK-ADN----- -------------------------------------------------------------------------------- ---------------------------------EPLIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLQNLAPGTHPPFITFNGEV--------KTDVNKIEEFLEDVLCPPKYIKL AARHPESNTAG--MDIFAKFSAFIKNP--RPDAN----EALERGLLKTLQKLDDYLRSPLPDEIDHNS-MEDIKVSRRNF LDGDEMTLADCNLLPKLHIVK--VVAKKYRGFDIP-KEMTAVWKYLNNAYSREEFTNTCPSDKEIEIAYEDVA------- ------KRLVK--------------------------- >Tetraodon_nigroviridis_CLIC4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MSLSVPQNGVK-PDN----- -------------------------------------------------------------------------------- ---------------------------------EPVIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLQNLAPGTHPPFITFNGEV--------KTDVNKIEEFLEDVLCPPKFIKL AARHPESNTAG--MDIFAKFSAFIKNP--RPDAN----EALERGLLKTLQKLDDYLRSPLPDEIDHNS-IEDIKVSNRNF LDGDEMTLADCNLLPKLHIVK--VVAKKYRGFNIP-KEMTAVWKYLNNAYSREEFTNTCPSDKEIEIAYEDVA------- ------KRLVK--------------------------- >Gasterosteus_aculeatus_CLIC4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MSLSVPQNGVK-ADD----- -------------------------------------------------------------------------------- ---------------------------------EPVIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLQNLAPGTHPPFITFNGEV--------KTDVNKIEEFLEDVLCPPKYIKL GVRHPESNTAG--MDIFAKFSAFIKNS--KPDGN----EALERGLLKTLQKLDEYLRSPLPDEIDHNS-IEDVKFSDRKF LDGDEMTLADCNLLPKLHIVK--VVAKKYRGFDIP-KEMTAIWKYLNIAYTREEFTNTCPSDKEIEIAYGDVA------- ------KRLVK--------------------------- >Oryzias_latipes_CLIC4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MSLSVPQNGIK-ADN----- -------------------------------------------------------------------------------- ---------------------------------EPIIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLQNLAPGTHPPFITFNGEV--------KTDVNKIEEFLEDVLCPPKFIKL GARHPESNTAG--MDIFAKFSAFIKNS--KPDAN----EALERGLLKTLQKLDEYLRTPLPDEIDHNS-IEDVKVSGRKF LDGDEMTLADCNLLPKLHIVK--VVARKYRGFDIP-KEMTAIWKYLNNAYTREEFINTCPSDKEIEIAYADVA------- ------KRLVK--------------------------- >Branchiostoma_floridae_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MENGGDQEEPKIELFVK----AASD------------------GTSLGDCVFCQR IFMIL---CLKKIKFS--VTTVDMTKKHLFKALPSLGTKIPFLMIDGEEP-------ITDVTEMANYLEKRLAPPMYPKL EPNNPEAAMAG--TEIFQKFSKFIKNS--SQADE----ERLQRALYISLVQLNEFLIRRLPDEIDDDT--DENSPSERKF LDGDQLTHPDCNLLPKLHHVR--VATKALKGFEIP-QDLTGLWRYLNSAYETEEFKKTLYPDEEIN-VYSDI-------- -------------------------------------- >Caenorhabditis_elegans_CLIC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------MAEAYQIQSNGDPQS----KPLLELYVK---ASGID------------------ARRIGADLFCQE FWMELYA-LYEIGVARVEVKTVNVN--SEAFKKNFLGAQPPIMIEEEKELTY------TDNREIEGRIFHLAKEFNVPLF EKDPSAEKRIE---NLYRNFKLFLRAK-VEFDKGK-----KEPSRVEDLPAQIKVHYNRVCEQLSNID--QLLSERKSRY LLGNSMTEYDCELMPRLHHIR--IIGLSLLGFDIP-HNFTHLWAYILTAYRTAAFIESCPADQDIIHHYKEQMN------ LFTNQRETLQSPTKTHTIPEKVLSDIRVKGLAPDVNVH >Homo_sapiens_CLIC5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MNDED YS-TIYDTIQNERTYEVPDQPEENESPHYDDVHEYLRPENDLYATQLNTHEYDFVSVYTIKGEETSLASVQSEDRGYLLP DEIYSELQEAHPGEPQEDRGISMEGLY------------------------SSTQDQQLCAAELQENGSVMKEDLPSPSS FTIQHSKAFSTTKYS--CYSDAEGLEEKEGAHMNPEIYLFVK----AGID------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFLTFNGDV--------KTDVNKIEEFLEETLTPEKYPKL AAKHRESNTAG--IDIFSKFSAYIKNT--KQQNN----AALERGLTKALKKLDDYLNTPLPEEIDANTCG-EDKGSRRKF LDGDELTLADCNLLPKLHVVK--IVAKKYRNYDIP-AEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVA------- ------KRLSRS-------------------------- >Pan_troglodytes_CLIC5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MTDSATANGDDR----- -------------------------------------------------------------------------------- ---------------------------------DPEIELFVK----AGID------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFLTFNGDV--------KTDVNKIEEFLEETLTPEKYPKL AAKHRESNTAG--IDIFSKFSAYIKNT--KQQNN----AALERGLTKALKKLDDYLNTPLPEEIDANTCG-EDKGSRRKF LDGDELTLADCNLLPKLHVVK--IVAKKYRNYDIP-AEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVA------- ------KRLSRS-------------------------- >Macaca_mulatta_CLIC5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MNDED YS-TIYDTIQNERTYEVPDQPEENESPHYDDVQEYLRPENDLYATQLNAYEYDFVSVYTINGEETSLASAQSEDRGYLLP DEIYSELQEAQPGELQEDRGISMEGLY------------------------SPTQDQQPCPEGLQENGSVMKEDLPSPSS FTIQHSKAFSISKYSSTCYSDAEGLEEKEGARMNPEICLFVK----AGID------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFLTFNGDV--------KTDVNKIEEFLEETLTPEKYPKL AAKHRESNTAG--IDIFSKFSAYIKNT--KQQNN----AALERGLTKALKKLDDYLNTPLPEEIDASTCG-EDKGSRRKF LDGDELTLADCNLLPKLHVVK--IVAKKYRNYDIP-AEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVA------- ------KRLSRS-------------------------- >Mus_musculus_CLIC5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MTDSATTNGDDR----- -------------------------------------------------------------------------------- ---------------------------------DPEIELFVK----AGID------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFLTFNGDV--------KTDVNKIEEFLEETLTPEKYPKL AAKHRESNTAG--IDIFSKFSAYIKNT--KQQNN----AALERGLTKALRKLDDYLNSPLPEEIDTNTHG-DEKGSQRKF LDGDELTLADCNLLPKLHVVK--IVAKKYRNYDIP-AEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVA------- ------RRLSRS-------------------------- >Oryctolagus_cuniculus_CLIC5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------MDSATANGDDR----- -------------------------------------------------------------------------------- ---------------------------------DPEIELFVK----AGID------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFLTFNGDV--------KTDVNKIEEFLEETLTPEKYPKL AAKHRESNTAG--IDIFSKFSAYIKNT--KQQNN----AALERGLTKALKKLDDYLNTPLPEEIDTNTRGDEDKGSRRKF LDGDELTLADCNLLPKLHVVK--IVAKKYRNYDIP-AEMTGLWRYLKNAYARDEFTNTCAADAEIELAYADVA------- ------KRLSRS-------------------------- >Myotis_lucifugus_CLIC5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------RVRYREIG------------------------SKSE------------------------- -------------------------------------VFVLT----AGID------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFLTFNGDV--------KTDVNKIEEFLEETLTPEKYPRL AAKHRESNTAG--IDIFSKFSAYIKNT--KQQNN----AALERGLNKALKKLDDYLSTPLPEEIDANTCGDDDKGSRRKF LDGDELTLADCNLLPKLHVVK--IVAKKYRNYDFP-AEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVA------- ------KRLSR--------------------------- >Gallus_gallus_CLIC5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------MSEP---------------SAANG--------DGK------------- ---------------------------------EPDIELFVK----AGID------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFLTFNGEV--------KTDVNKIEEFLEETLAPPKYPKL AAKHRESNTAG--IDIFSKFSAYIKNT--KQQDN----AALERGLVKALKKLDDYLRTPLPEEIDANS-TEEEKVSKRKF LDGDDLTLADCNLLPKLHVVK--IVAKKYRNFEFP-TEMTGLWRYLKNAYARDEFTNTCAADKEIEQAYADVA------- ------KRLSKS-------------------------- >Taeniopygia_guttata_CLIC5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------MTDS---------------VAANG--------EGK------------- ---------------------------------DPEIELFVK----AGID------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFLTFNGEV--------KTDVNKIEEFLEEILAPPKYPKL AAKHRESNTAG--IDIFSKFSAYIKNT--KQQDN----ATLERGLVKALKKLDDYLRTPLPEEIDADS-TEEEKVSKRKF LDGDELTLADCNLLPKLHVVK--IVAKKYRNFEFP-AEMTGLWRYLKNAYTRDEFTNTCAADKEIEQAYADVA------- ------KRLSKS-------------------------- >Pelodiscus_sinensis_CLIC5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MEKGGFTTIYENVENTSIYEIPDSEEE KVMNLYEQVHEDPVFPSSPTSPESMDISCLESLDHSCSNSVSSQQGADREDCSATSQQAADGDDSSASSQQGDDGDDGSA SSQQGADGEDGSASSQQGAEDDQNLQ--EEMVMMSP---------------TQDDE--------HGERMGFENKIPSPTR FSLRNSLGTSPSLPVSNRFPANNNFGEMDNFQEESDIFLFVK----AGID------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFLTFNGEV--------KTDINKIEEFLEEMLVPPKYPKL AATHRESNAAG--IDIFSKFSAYIKNT--RQQDN----AGLERGLTKALKKLDNYLNTPLPEEIDANS-TEEEKVSKRKF LDGDELTLADCNLLPKLHVVK--IVAKKYHNYEFP-TEMTGLWRYLKNAYARDEFTNTCAADKEIEQAYADVA------- ------KRLSKP-------------------------- >Takifugu_rubripes_CLIC5_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------QVGDRERR---------- ----------------------GEDKD----------------------------------------------------- ----------------------------------PDIELFVK----AGND------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLKRKPADLHNLAPGTHPPFVTFNGEV--------KTDINKIEEFLEEMLSPPKYPKL AAKQRESNTAG--NDIFAKFSAYIKNT--KLDAN----SALEKGLTRALIKLDDYLNNPLPDEIDADS-LEEQKFSTRSF LDGNELTLADCNLLPKLHIVK--VVAKKYRNYEIP-SEMSGVWRYLKNAYKRDEFTNTCAADAEIEMAYKDVV------- ------KRLAK--------------------------- >Tetraodon_nigroviridis_CLIC5_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------RLVAAEWR---------- ----------------------GEDKD----------------------------------------------------- ----------------------------------PDIELFVK----AGSD------------------GESIGNCPFSQR LFMIL---WLKGVVFN--VTTVDLRRKPADLHNLAPGTHPPFVTFNGEV--------KTDINKIEEFLEEMLGPPKYPKL AAKHRESNTAG--NDIFAKFSAYIKNT--KPEAN----SGLEKGLTRALNKLDDYLNNPLPDEIDADS-MEEQKFSTRSF LDGDQLTLADCNLLPKLHIVK--VVAKKYRNYDIP-SDMSGVWRYLKNAYKRDEFTNTCAADGEIETAYKDVA------- ------KRLAK--------------------------- >Homo_sapiens_CLIC6 -------------------------------------------------------------------------------- ---MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAG---------GGGPDR- ---------GPEAEARGTRGAHGETEAEEG----APEGAEVPQGGEETSGAQQVEGASPGRGAQGEP---RGEAQREPED SAAPERQEEAEQRPEV--PEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEG-PAGDSVDAEGPLGD NIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAG----DPAGDGVEAGVPAGDSVEAEGPAGDSMDAEG PAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWD-------AAEEAEVPGVKGSEEAAP--GDARADAG EDR----------------VGDGPQQEPGE-DEERRERSPEGPREEEAAGGEEESPDSSPHGEASRG--AAEPEAQLSNH LAEEGPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFV----KAGYD------------------GESIGNCPFSQR LFMIL---WLKGVIFN--VTTVDLKRKPADLQNLAPGTNPPFMTFDGEV--------KTDVNKIEEFLEEKLAPPRYPKL GTQHPESNSAG--NDVFAKFSAFIKNT--KKDAN----EIHEKNLLKALRKLDNYLNSPLPDEIDAYS-TEDVTVSGRKF LDGDELTLADCNLLPKLHIIK--IVAKKYRDFEFP-SEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVA------- ------KRMK---------------------------- >Pan_troglodytes_CLIC6 -------------------------------------------------------------------------------- ---MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAG---------GGGPDR- ---------GPEAEARGTRGAHGETEAEEG----APEGAEVPQGGEETSGAQQVEGASPERGAEGEP---RGEAQREPED SAAPERQEEAEQRPEA--PEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVDAEGPAGDSVDAEG-PAGDSVDAEGPAGD SVDAECPAGDSVEAEG----------------------------------PAGDSAEAGVPAGDSVEAEGPAADSMDAEG PAGRARRVSGEPQEAGDGSLSPQAEAIEVAAGESAGRSPGELTWD-------AAEEAEVPGGKGSEEAAP--GDARADAG EDG----------------VGDGPQQESGE-DEDRREGSPEGPREEAAARGEEESPDSSPHGEASRG--AAEPEAQLSNH LAEEGPAEGSDEAARVNGRREDGEASEQRALGQEHDITLFV----KVKLTALGCSRIAIKKYLRAGYDGESIGNCPFSQR LFMIL---WLKGVIFN--VTTVDLKRKPADLQNLAPGTNPPFMTFDGEV--------KTDVNKIEEFLEEKLAPPRYPKL GTQHPESNSAG--NDVFAKFSAFIKNT--KKDAN----EIHEKNLLKALRKLDNYLNSPLPDEIDAYS-TEDVTVSGRKF LDGDELTLADCNLLPKLHIIK--IVAKKYRDFEFP-SEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVA------- ------KRMK---------------------------- >Macaca_mulatta_CLIC6 -------------------------------------------------------------------------------- ---MAEAAEPEGGAPGPQGPLEVPAPLAERPGEPGSAGEEAEEPEGSEGAEEAPRGAAAVKEAG---------GGGPDR- ---------GPEAEAWGTRGAHREAEAEEG----APEVAQVPQGGEKTSSAQQVEGASPGRGAQGEP---RGEAQREPED SAAPERQEEAEQRPEA--PEGSAPGAAGDSVDAEGPAGDNIEAEGRVGDSVEAEVPAGDSVDAEG-PAGDSVDAEGPAGD SVDAEGPAGDSVDAEGLAGDSVEAEGPAGDSVDAEGPAGDSVEAG----DPVGDRVEAGDPVGDTVEAEGPAGDSMDAEG PAGGTRRVSGEPQEGGDRSLPPQAEAIEVAAGESAGRSPGELAWD-------AAEETEVPGGKGSEEAGP--GDSRADAV EDG----------------VGDGPQQESGE-EEERREQSPEGPSEEAAAGGEEEFPDSSPQGEASRC--AAEPEAQLSNH LAEEGPAEGGDEAVRMNGRREDGEASEERALGQEHDITLFV----KAGYD------------------GESIGNCPFSQR LFMIL---WLKGVIFN--VTTVDLKRKPADLQNLAPGTNPPFMTFDGEV--------KTDVNKIEEFLEEKLAPPRYPKL GTQHPESNSAG--NDVFAKFSAFIKNT--KKDAN----EIYEKNLLKALRKLDNYLNSPLPDEIDAYS-TEDATVSGRKF LDGDELTLADCNLLPKLHIIK--IVAKKYRDFEFP-SEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVA------- ------KRMK---------------------------- >Mus_musculus_CLIC6 -------------------------------------------------------------------------------- ---MAEATEPKEVAPGSQGQPEGAT--IEGPGEPGAAD--LEGREASEEAAEAPRDLGAGVEARASGKEEGGCGQDEGTG GAQAQDPRTGPEAETPGASGAPGEAEAAER----DPEGA-IPQGAEEAPSAQQVQGMSSGLDSQGEAPEVPGDSRREPED PTASEAGEEAESGQEA--QGGGALGLQIN--------------------------------------------------- -----------------------------------------------------------------PEVQGLAGDNMDTEA PAGGPLGSESEPQGGGESSPQPQDEAIEIVTTEIGGNESGELAGA---SAADAAGEGETLGKDGSEEAAS--EDARVDAH ENG-----------------DQGKLQEETGEEEARPEPELKGPCEGAIQEKPPDGSLDGEEAKSTEH--EEESQAELSNH LAEEPSVQGGEELGRVNGRRENGPALEEGDPGQEHDITLFV----KAGYD------------------GESIGNCPFSQR LFMIL---WLKGVIFN--VTTVDLKRKPADLQNLAPGTNPPFMTFDGEV--------KTDVNKIEEFLEEKLVPPRYPKL GTQHPESNSAG--NDVFAKFSAFIKNT--KKDAN----EIYEKNLLRALKKLDSYLNSPLPDEIDADS-SEDVTVSQRKF LDGDELTLADCNLLPKLHIIK--IVAKKYRDFEFP-SEMTGIWRYLNNAYARDEFTNTCPADREIEHAYSDAA------- ------KRMK---------------------------- >Rattus_norvegicus_CLIC6 -------------------------------------------------------------------------------- ---MAEATEPKEVSSGSQGQPEGAV--IEGPGEPGAAD--LEGREASEGAAEAPRDLGEGAEAMASGKEEGGCGQDGEIG EVQAQDPRPGPGTETPGTSGAPGEAEAAEC----DSEGALIPQGAEEAPSAQQVQGTSSGLDAQGEAPEVPEDARREPED PKASEAGEEAESGQEA--LGGSAPESQIN--------------------------------------------------- -----------------------------------------------------------------PEVQGPVGDNMDTEA PAGEPQGSEGEPQGGGESSPQPQDEAIEIAAAEVGGHEPGELAGA---SAADAKGEGETLRKDGFEEAAP--EEARVDSG ENGFEEAAPEEARVDSGENRDQGRLQEETGEEEARPESGLKGPCEEAIQEKAPDGSLDGEEAKSTGH--EE-SQVELSNH LAEETSAQGGEELGRVNGRRENGPASEEGDLGQEHDITLFV----KAGSD------------------GESIGNCPFSQR LFMIL---WLKGVIFN--VTTVDLKRKPADLQNLAPGTNPPFMTFDGEV--------KTDVNKIEEFLEEKLVPPRYPKL GTQHPESNSAG--NDVFAKFSAFIKNT--KKDAN----DIYEKNLLRALKKLDSYLNSPLPDEIDAYS-TEDVTVSQRKF LDGDELTLADCNLLPKLHIIK--IVAKKYRGFEFP-SEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDAA------- ------KRMK---------------------------- >Loxodonta_africana_CLIC6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------AGYD------------------GESIGNCPFSQR LFMIL---WLKGVIFN--VTTVDLKRKPADLQNLAPGANPPFMTFDGEV--------KTDVNKIEEFLEEKLAPPRYPKL GTQHPESNSAG--NDVFAKFSAFIKNT--KKDAN----DIYEKNLLRALKKLDSYLSSPLPDEIDAYS-TEDVPVSGRKF LDGDELTLADCNLLPKLHVIK--IVAKRYRDFEFP-PEMSGLWRYLNNAYARDEFANTCPADQEIVHAYSDVA------- ------KRMNK--------------------------- >Pteropus_vampyrus_CLIC6 -------------------------------------------------------------------------------- ---MAEATEPEGGAPGPQGPPEGPAPLADRPGEAGAAGLAANGEQAGERAAEARRGVAAGTER-----EGDELAPGTDR- ---------DPGTEKPGSSGAQSEPQAEEG----APQGAEAPQGGEEKGSAQQVEEASVGCGAQGEE------AQGERGD PAAPKAEEEAERGPEE--PGSSARGAPRTSVDVGGLRGSSMEAEG----------------------------------- -------------------------------------------------------------------------------- SEGAAPRAEEVPRDGGDRSSQSHVQATEAAAAETADCTPGELCGEPQGAAGGAAEEAGAPGEEDSEEASP--GDAKADAR EDG----------------AGG---PQEEEAEEERRERGPEGPGEEAPPDGSAPGGDAQTR--------AAEPEGQLSNH LAAEGSAEDAAEAARVNGRGEDGEASEEGAPRREHDITLFVKVTHAAGYD------------------GESIGNCPFSQR LFMIL---WLKGVIFN--VTTVDLKRKPADLQNLAPGTNPPFMTFDGEV--------QTDVNKIEEFLEEKLAPPRYPKL GTQYPESNSAG--NDVFAKFSAFIKNT--KKDVN----EXYEKNLLKALKKLDNYLNSPLPDEVDVYS-TEEVAVSGRKF LDGDELTLADCNLLPKLHIIK--IVAKRYRDFEFP-PDMTGIWRYLHNAYARDEFTNTCPADQEIEHAYSDVA------- ------KRMK---------------------------- >Gallus_gallus_CLIC6 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