>Homo_sapiens_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS PTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRA----ADDGEG-------------------------IVGAAMPDSGP- ----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP---------------------- ------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV VDMRLREGAA----PGAARPTAPN------AQTPSHLGAT--------------------LPVGQP--VGGDPE------ -------VRKQMPPPPPCPAG-----RELFDDPSYVNVQNLDKARQAV---GGA-----GPPNPAINGSAPRDLFDMK-- ----------------PFEDALRVP-----------------------PPPQS--------VSMAEQLRGEPWFHGKLSR REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVERKL -------------- >Gorilla_gorilla_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS PTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRA----ADDGEG-------------------------IVGAAMPDSGP- ----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP---------------------- ------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV VDMRLREGAA----PGAARPTAPS------AQTPSHLGAT--------------------LPVGQP--VGGDPE------ -------VRKQMPPPPPCPAG-----RELFDDPSYVNVQNLDKARQAV---GGA-----GPPNPAVNGSAPRDLFDMK-- ----------------PFEDALRVP-----------------------PPPQS--------VSMAEQLRGEPWFHGKLSR REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVERKL -------------- >Macaca_mulatta_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS PTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRA----ADDGEG-------------------------IVGAAMPDSGP- ----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP---------------------- ------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV VDMRLREGAA----PGAARSTAPS------AQTPSHLGAT--------------------LPVGQP--VGGDPE------ -------VRKQMPPPPPCPAG-----RELFDDPSYVNVQNLDKVRQAV---GGA-----GLPNPAVNGSAPRDLFDMK-- ----------------PFEDALRVP-----------------------PPPQS--------VSMAEQLRGEPWFHGKLSR REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVERKL -------------- >Mus_musculus_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS PTTLCSFFPRMSNLKLANPAGGRLGPKGEPGKA----AEDGEG-------------------------SAGAALRDSGL- ----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP---------------------- ------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV VDMRLREGA--------ARPTLPS------AQMSSHLGAT--------------------LPIGQH--AAGDHE------ -------VRKQMLPPPPCP-G-----RELFDDPSYVNIQNLDKARQAG---GGA-----GPPNPSLNGSAPRDLFDMK-- ----------------PFEDALRVP-----------------------PPPQS--------MSMAEQLQGEPWFHGKLSR REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVDRKV -------------- >Canis_familiaris_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDES PTTLCSFFPRMSNLKLANPAG-------EPGRA----SKDGEG-------------------------TGGAAVLDSAP- ----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP LSAILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP---------------------- ------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV VDMRLREAAP----LGAVRPTPHV------VQTPSHLGAT--------------------LPVGQP--VGGDPE------ -------IRKQMPPPPPCP-G-----KELFDDPSYVNVQNLDRARQAG---GGA-----GPPNPAINGSVPRDLFDMK-- ----------------PFEDALRVP-----------------------PPPQA--------VAMAEQLRGEPWFHGKLSR REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHVDNHLPIISAGSE----LCLQQPVERKL -------------- >Myotis_lucifugus_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MDLLPPKPKYNPLRNESLSSLEEGAS--GSSPPE---------------ELPSPSASSLGPILPP----QAGDDS PTTLCSFFPRMSNLKLANPAGARPGPKGEPGRV----AEDGEG-------------------------VAGAAVPDSGP- ----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ASRRRKPCSRP LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP---------------------- ------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV VDMRLREGAP----QGPARPTLPS------AQNPSHLGAT--------------------LPVGQP--AGGDPE------ -------VHKQMPPLPPCPAG-----REIFDDPSYVNIQNLDKARQAG---GGA-----GPPNLAVNGSAPRDLFDMK-- ----------------PFEDALRVP-----------------------PPPQS--------VAMAEQLRGEPWFHGKLNR REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVERKL -------------- >Pteropus_vampyrus_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS PTTLCSFFPRMSNLKLANPAGGRLGPKAEPGRA----AEDGEG-------------------------TTGAAVPDSGP- ----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP---------------------- ------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV VDMRLREGAA----PGATRPTPPS------AQPPTQLGAT--------------------LPVGQP--VGGDPE------ -------VRKQMPPPPPCPAG-----RELFDDPSYVNVQHLDKARHAG---AGA-----GPPGLAVNGGAPRDLFDMK-- ----------------PFEDALRAP-----------------------PPPHS--------VAMAEQLRGEPWFHGKLSR REAEALLQLDGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SHHMDNHLPIISAGSE----LCLQQPVTRRP -------------- >Xenopus_tropicalis_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MDLLP-KTKYNHLRNESVSSVEEALA--AGPLSP--------SVEIMVSLPSSASSSSLAPMLPLAELSSESEES PTTLCSFFPKMANLKLSNPANLLNLRSFSSSMGGKESASPGEQ----------------------GDTPNEGSSPESGRT F---------------TVFSQDMNKLSCG--RKSR------------VEGGQLAGDEWTRHGSFVNKPTRGWLHPDDKVM G-----PGVPYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCDAV---PGAKG-AMRRRKTCGRS LNSILG-KSNLKFAGMPITLTVSTSSLNLMASDCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LKNPP---------------------- ------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------LPDHAYYNDFPGKEPPIGGV VDMRLRDGVA----PA------VP------RQSPNHMGAT--------------------LPVGQV--SGAEQD------ -------SRKPQPTVQVPCSRPPN-RPDLFDDPSYVNVQNLEKSRQP--LRQQT-----ARDPMGTNAVGTTTNFPVA-- ----------------PVEPFEDAL-----------------------PSAQ-------AVVSMEDQLKRESWYHGKMNR KEAERLLKVNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQCGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNRLPIISAGSE----LCLQQPVERRQ -------------- >Danio_rerio_SHC1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------MEYVDMNRLGGAS-RRAR------------VEGGQLGGDEWTRHGSFVNKPTRGWLHSDIVVS T-----SGVSYTVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISVVCEAV---PGAKG-AQRRRKPSSRC LSSILG-KSNLQFAGMTITLTVSTSSLNLMAIDCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECSEGLAQEVIST-------IGQAFELRFKQY-------------LKNPP---------------------- ------------------KVVTPHDRM----------APFDGSAWEEEEED------LAPPPEVPYYNNFPGKQPPPGGL VDMRTRPGHS----TGP------------------------------------------TLPYGQP----SQND------ -------IHKQPLPPLPVGVKDGG----LFDDPSYVNVD---KPRLPA--------------SAAANGNAHRDAFDMK-- ----------------PFDAALVVS-----------------------GAV--------ALP-LAEQLQNEPWFHGPLSR RQAERLLTKDGD----------------------------------FLVRESGTTPGQ---------YVLTG-QQGGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNRLPIISAGSE----VCLQQPVDRKA -------------- >Takifugu_rubripes_SHC1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------MELAPKTKYTHFRSESLSSTDETNSNPSSVPPSSPVS----PLTPSPGMPSSLSSSSLTPILPPCS-PHPAENS PTTLCSFFPRMGSLRLGVSATLLPSFKTASRPQNTRAPVESSGDDQSRA------------RPSPPVHHPLPPLT----- ---------------------DMNRLGGAS-RRAR------------VEGGQLGGDEWTRHGSFVNKPTRGWLHSDGVVS T-----SGVSYTVRYMG-------CVEVLQSMRALD--FSTRTQ---VTREAIAVVCEAV---PGAKG-AQRRRKPSSRC LSSILG-KSNLQFAGMTISLTVSTSSLNLLACDCK-QIIAN----HHMQSISFASGGD-----PETAEYVAYVAK--DPV NQRACHILECSEGLAQEVIST-------IGQAFELRFKQY-------------LKNPP---------------------- ------------------KLVTPHDRM----------APFDGSAWEEEDEE------PPPPPDVPYYNNFPGKQPPPGGL IDMRTRPGAT----LVR---SMHI------SPTPIEETET--------------------IPYGQP----GQND------ -------IHKQPLPPLPAGAKEGG----LFDDPSYVNVD---KPRPR----------------VASNGNMHRDAFDMK-- ----------------PFDDALGVS-----------------------GHSGTS-SASAAPP-LVQQLQCEAWFHGGLSR KEAERLLTRDGD----------------------------------FLVRESGTTPGQ---------YVLTG-QQGGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNRLPIISAGSE----VCLKQPVERRA -------------- >Tetraodon_nigroviridis_SHC1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------MELSPKTKYTHFRSESLSSTDETNSNLSSFPPSSPVT----PLTPSPGVPSSHSSSSLTPILPPCS-PRPAENS PTTLCSFFPRMGSIRLGVSATLLPSLKIASRPQNTQAPAESSGEDRSSS------------SS----------------- -------------------LQDMNRLGGAS-RRAR------------VEGGQLGGDEWTRHGSFVNKPTRGWLHSDSVVS T-----TGVSYTVRYMG-------CVEVLQSMRALD--FSTRTQ---VTREAISVVCEAV---PGAKG-AQRRRKPSSRC LSSILG-KSNLQFAGMTISLTISTSSLNLLACDCK-QIIAN----HHMQSISFASGGD-----PETAEYVAYVAK--DPV NQRACHILECSEGFAQEVIST-------IGQAFELRFKQY-------------LKNPP---------------------- ------------------KLVTPHDRM----------APFDGSAWEEEDEE------TAPPPDVPYYNNFPGKQPPPGGL IDMRTRPGAT----LEHN--KWKL------SNANVNGSFFSVAPC--------------LQPYGQP----GQND------ -------IHKQPLPPLPAGAKEGG----LFDDPSYVNVD---KPRPP----------------AASNGNMHRDAFDMK-- ----------------PFDDALGVS-----------------------GHGGPS-SASAAPP-LVQQLQCEAWFHGGLSR KEAERLLTRDGD----------------------------------FLVRESGTTPGQ---------YVLTG-QQGGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNRLPIISAGSE----VCLKQPVERRA -------------- >Gasterosteus_aculeatus_SHC1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------MELVPKTKYTHFRSESLSSTDETNSDPSPLPPSSPAT----PLTPSPGLPPSLSSSSLAPILPPSS-PRQAENS PTTLCSFFPRMGSLRLGVSATLLP------------------GGDRSSS------------GSSPPLHRPTAPLTAPSPP P---------------RPTLQDMNRLGGAS-RKARSEGAARKA---RVEGGQLGGDEWTRHGSFVNKPTRGWLHSDGVVT T-----AGVSYSVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISVVCEAV---PGAKG-AQRRRKPSSRC MTSILG-KSNLQFAGMTISLTISTSSLNLLASDCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NQRACHILECSEGLAQEVIST-------IGQAFELRFKQY-------------LKNPP---------------------- ------------------KLVTPHDRM----------APFDGSAWEEEEEDDNAAAAAAPPPDVPYYNNFPGKQPPPGGL VDMRSRPGAT----LPR--EAALM------SNATFAQKGCR-LAE--------------LLPYGQP----GQND------ -------IHKQPLPPLPVGAKEGGR--ELFDDPSYVNVD---KPRHP----------------VAANGNAHRDAFDMK-- ----------------PFDDALGVS-----------------------GPGGAS-SSTAAPPPLVQQLQCEAWFHGSLSR REAERLLTRDGD----------------------------------FLVRESGTTAGQ---------YVLTG-QQGGQPK HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNSLPIVSAGSE----VCLQQPVERRA -------------- >Oryzias_latipes_SHC1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------LVPKTKYTHFRSESLSSNDDTNSNPSSFPPSSPAT----PLTPSPGIPSSLSSSSLTPILPPTS-PRPAENS PTTLCSFFPRMSSLRLGVTATLLPGLKASSRSQPSQLAVESSGDDRSNS------------SSSPPLHQPAPLLTAPSPP P---------------RPPLQDMNRLGGAS-RRAR------------VEGGQLGGDEWTRHGSFVNKPTRGWLHSDSVVS T-----TGVSYTVTYMG-------CVEVLQSMRALD--FNTRTQ---VTREAIAVVCEAV---PGAKG-A-RRRKPSSRC LTSILG-KSNLQFAGMPISLTISTSSLNLLASDCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV NHRACHILECTEGLAQEVIST-------IGQAFELRFKQY-------------LKTPP---------------------- ------------------KLVTPHDRM----------APFDGSAWDEEDDE------IAPPPEVPYYNNFPGKQPPPGGI IDMRTRSGAT----LVRRHPLMHT------TQHIRIQRGLQHRDD--------------KPLYGQQ----GQND------ -------IHKQPLPPLPG-AKEGTR--ELFDDPSYVNVD---KPRPP----------------LAANGNANRDAFDMRKL DGKRKKKLLEPNIIEEPLDDALGVS-----------------------GTS--------APP-MVQQLQNEIWFHGSLTR REAERLLTRDGD----------------------------------FLVRESGTTPGQ---------YVLTG-QQGGQPK HLLLVD--------PEGV----VRTKDHRFGSVSHLI------------SYHLDNRLPIVSAGSE----VYLQQPVERRA -------------- >Ciona_intestinalis_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------MRRNKKLVEGDQTNEWR------------------------KSGSFVNKPQRGWLHPDSSVM G-----PGVVYSVQYLG-------CVEVRQSMRTLD--FDMRTL---ATKEAIWRVLASTGMSPLPPAANRSGRKKPPKD VTRILGERPNLKFSQSFINLTISTASLTLVVSNTG-QFIAN----HQMQSISFASGGD-----PDTIDYVAYVAK--DPI NSRACHVLKCTDGLAQDVINT-------IGQAFELRFKEY-------------LKNPP---------------------- ------------------KAVTPPDRTEP-------LFHDGKSRWGDDEPE--------------YYNEIPGKLAPESGL KRLDDGSKID--------------------EGAVVYPNHHNSQE---------------YINNGMQSECSAPTP------ ----------TLSTPTPRRTP------RNFEDHNYVNTCVMPHGQEPT-----------------NQKRPSVDAFDMR-- ----------------PFANTLNPP---------------------------------ATPTSATNALQSKPWFHGHVTR KEAEQLLSHDGD----------------------------------FLVRESTTTKGQ---------FVLSG-VQDGQYK HLLLVD--------PNGV----VRTKDRQFDSVSHLI------------SFHRDNTLPIVSSGSV----LLLRQPVTRQI ER------------ >Branchiostoma_floridae_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MVAT---TTWAGITGFPLTF------------KRKATWEV LSTPGG-------DGVSPCTTSAHAFLSDMTAARS----------SSASPVSLESSLG-----KETQDYVAYVAK--DXV NSRACHVLHCPGGLAQDVITT-------IGQAFELRFKDF-------------LKNPP---------------------- ------------------KAVSAPDRL-------------EDPIFEEGESAWG--------DDPEYYNEIPGKLPPTGGM PPPLPAGPPPG-HYQAPSNLQASDGVYSSVKDAPSRPGPTYDNKASADN--------LIDFTAETPTAPVYDNPLHEPAG RGPPVSHGNDLPPEAAQPRSE-----VSLFDDPTYDNRRIENRPMHPDPMGAQQP--PQQPPQRPPLPLPAQDPFNMG-- ----------------PFDAGLQQDP-----------------------------------ASPPHPLYQEEWFHGPMTR KQAEELLEEDGD----------------------------------FLVRESERKYDIT-GP-----VVLTCLCLCAGER KYNITG--------PVVLTCLCLCAGERKYDITGPVVLTCLCLCAGER-KYDITGPVVLTACWRQSQ-TPATGGPTGHKL E------------- >Apis_mellifera_SHC1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------MATGG--SS----------------------------------FISKPARGWLHPDHLVS K-----EGITYTVKYIG-------CLEVYTSMKSLD--FETRSC---VAKECINRVCEAAG--LKSAD---KKRRVDRKV LRAIAD-KPRMEHTGATINLTISSCSLALTNIENG-HIIAK----HEMPRISFASGGD-----TEILDFVAYVAK--NMQ EWRACYVLECGGGLAQDVIST-------IGQAFELRFKEF-------------LTKPAS--------------------- ------------------LHPILNGIR---------------------------------EADRDYYNDLPGKVPPDIGP PPVPPLPTSA----STLPNLKHHH------SVQNHISRSNIQNSGL-------------HDTFSISSDRHHQQW------ --------AETGNLIDLNSDGTST-NFNIPPEHNYVNDSVIAASRENQRDQTSLF----DVFDMQPFSSAISDMNKLSP- -------------------------------------------------------------HSQKQQLKQEIWFHGSVSR AEAESMLTRDGD----------------------------------FLVRESQGSPGQ---------YVLTG-MNNNTPK HLLLID--------PEGV----VRTKDRVFDSVSHLV------------NHHCDNVLPIISADSV----LVLRYPIPRRT NN------------ >Homo_sapiens_SHC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MTQGPGGRAPPAPPAPPEPEA PTTFCALLPRMPQWKFAAPGGFLGRGPAAAR---------AAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCP L-----------------PALSRCRGAGSRGSRGGRGAAGSG--------DAAAAAEWIRKGSFIHKPAHGWLHPDARVL G-----PGVSYVVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA LASVLG-KSNLRFAGMSISIHISTDGLSLSVPATR-QVIAN----HHMPSISFASGGD-----TDMTDYVAYVAK--DPI NQRACHILECCEGLAQSIIST-------VGQAFELRFKQY-------------LHSPP---------------------- ------------------KVALPPERL---------AG-PEESAWGDEEDS----------LEHNYYNSIPGKEPPLGGL VDSRLALTQ-----PCALTALD----------QGPSPSLR--------------------DACSLPWDVGSTG------- ----TAPPGDGYVQADAR--G-----PPDHEEHLYVNTQGLDAPE--------------------PEDSPKKDLFDMR-- ----------------PFEDALKLHECSVAAGV-------TAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSR RAAERMLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK HLLLVD--------PEGV----VRTKDVLFESISHLI------------DHHLQNGQPIVAAESE----LHLRGVVSREP -------------- >Pan_troglodytes_SHC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------YMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA LASVLG-KSNLRFAGMSISIHISTDGLSLSVPATR-QVIAN----HHMPSISFASGGD-----TDMTDYVAYVAK--DPI NQRACHILECCEGLAQSIIST-------VGQAFELRFKQY-------------LHSPP---------------------- ------------------KVTLPPERL---------AG-PEESAWGDEEDS----------LEHNYYNSIPGKEPPLGGL VDSRLALTQ-----PCALTALD----------QGPSPSLR--------------------DACSLPWDVGSTG------- ----TAPPGDGYVQADAR--G-----PPGHEEHLYVNTQGLDAPE--------------------PEDSPKKDLFDMR-- ----------------PFEDALKLHECSVAAGV-------TAAPT-VEDQWPSPPTR----------------------- -------RSDGD----------------------------------FHVRESVTNPRL---------YVLTG-MHAGQPK RLLVLD--------TEGV-------------------------------------------------------------- -------------- >Macaca_mulatta_SHC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------QYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA LASVLG-KSNLRFAGMSISIHISTDGLSLSVPATR-QVIAN----HHMPSISFASGGD-----TDMTDYVAYVAK--DPI NQRACHILECCEGLAQSVIST-------VGQAFELRFKQY-------------LHSPP---------------------- ------------------KVALPPESL---------EMNPQRQAGGWDSNSG---------LPAPSKSSSCGGLAPLGPA CATRRRLSS-----QPTLDTSD----------EGPSASLR--------------------DARSLPWDVGSTG------- ----AAPPGDGYVQADAR--G-----PPDLEEHLYVNTQGLDAPE--------------------PEDSPKKDLFDMR-- ----------------PFEDALKLHECSVAAGM-------TAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSR RAAERMLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK HLLLVD--------PEGV----VRTKDVLFESISHLI------------DHHLQNGQPIVAAESE----LHLRGVVSREP -------------- >Mus_musculus_SHC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MTQGPGGRAAPE------PEA PTTFCALLPRMPQWKFAAPGSFLGRGPAATR---------VAG--------VAEAQPEPGVPALAAVLGACEPRCAAPCP L-----------------PALGRCRGSGTRGARVTPD----------------VADEWVRKGGFIHKPAHGWLHPDARVL G-----PGVSYIVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA LASILG-KSNLRFAGMSISVNISVDGLNLSVPATR-QIIAN----HHMQSISFASGGD-----TDMTDYVAYVAK--DPI NQRACHILECCEGLAQSVIST-------VGQAFELRFKQY-------------LHSPP---------------------- ------------------KAVVPPERL---------TG-LEELAWGDDDAA----------ADHNYYNSIPGKEPPLGGL VDSRLAVTQ-----PCALATLGG-------LGQGMTPVWR--------------------DARGLPWDMGPSG------- ----AAPPGDGYVQADAR--G-----PHDYEEHLYVNTQGLDAVEL---EDTAE-------APLQFEDSPKKDLFDMR-- ----------------PFEDALKLHACSVAAGI-------TAASPPLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGRMSR RAAEKLLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK HLLLVD--------PEGV----VRTKDVLFESISHLI------------DYHLKNGLPIVAAESE----LHLRGVVSREP -------------- >Canis_familiaris_SHC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MTQGPGGRTPPAPPAPPEPEA PTTFCALLPRMPEWKFAAPAGFLGRGPAAARTAGGAGGAGGAGGAGGADPQPEEAAPGGVPALAAAVLGACEPRCAAPCP L-----------------PALSRCRAAGARGPRGARGGAGPP--------DAAAAAEWIRKGSFIHKPAHGWLHPDARVL G-----PGVSYIVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA LASILG-KSNLRFAGMSIAVSISTDGLNLSVPATR-QIIAN----HHMQSISFASGGD-----TDMTDYVAYVAK--DPI NQRACHILECCEGLAQSIIST-------VGQAFELRFKQY-------------LHSPP---------------------- ------------------RVAVPPERL---------TR-PEESAWGDEDEA-----------DHNYYNSIPGKEPPPGGL VDSRLALAQ-----PGAL---GA-------LGQGAAPARR--------------------DARSLPWDLGPSG------- ----AGPPGDGYVQADAR--G-----PRDYEDHLYVNTQGLDAPE-----------------PPQAEDSPKKDLFDMR-- ----------------PFEDALKLHECSAGAGT-------AVAPLPVEDQWPSPPTRRAPIAPTEEQLRQEPWYHGQMSR RAAEKLLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK HLLLVD--------PEGV----VRTKDVLFESISHLI------------DYHLQNGQPIVAAESE----LHLRGVVKREP -------------- >Felis_catus_SHC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------YMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGIRG--SWKKKAPNKA LASILG-KTNLRFAGMSIAVSISTDGLNLSVPATR-QVIAN----HHMQSISFASGGD-----TDMTDYVAYVAK--DPI NQRACHILECCEGLAQSIIST-------VGQAFELRFKQY-------------LHSPP---------------------- ------------------RVVLPPERL---------TR-PEESAWGDEEET-----------EHNYYNSIPGKEPPLGGL VDSRLALTQ-----PCAV---GA-------LGQGVSPARR--------------------DTRSLPWDLGPSG------- ----NSPPGDGYVQADAR--G-----PRDYEDHLYVNTQGLDAPE-----------------PLQPEDSPKKDLFDMR-- ----------------PFEDALKLHECSAGAGA-------AVAPLPLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGQMSR RAAEKLLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK HLLLVD--------PEGV----VRTKDVLFESISHLI------------DYHLQNGQPIVAAESE----LHLRGVVKREP -------------- >Pteropus_vampyrus_SHC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------YMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA LASILG-KSNLRFAGMSIAVSISTDGLNLSVPATR-QIIAN----HHMQSISFASGGD-----TDMTDYVAYVAK--DPI NQRACHILECCEGLAQSVIST-------VGQAFELRFKQY-------------LHSPP---------------------- ------------------KAVAPLERL---------TG-LEESAWGDEEDT-----------DHNYYNSVPGKEPPLGGL VDSRLALTQ-----PCAL---GG-------LGQGASPVRR--------------------DARGLQWEPGSSG------- ----TASAGDGYVQADAR--G-----PRDYEDHLYVNTQGLDAPE-----------------SLPPEDSPKKDLFDMR-- ----------------PFEDALKLHECSVAAGT-------AAAPLPSEDQWPSPPTRRAPIAPTEEQLRQEPWYHGQMSR RAAEKLLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK HLLLVD--------PEGV----VRTKDVLFESISHLI------------DYHLQNGQPIVAAESE----LHLRGVVKREP -------------- >Xenopus_tropicalis_SHC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MLAESRYDRFRNDSITSAEEQLALSAEAMSGQVAPSSPTGASALEPQYPEEQDV ATTFCMMIPRMGQWKFSSPTAFLSRSPSGAN-------------------KELTVDKSGTGGGLGSVFGACDPVCSTPCT L-----------------QVINRLRGGGSGGARKSARTEAY----------KVQGEEWNRKGTFINKPAQGWLHPDDRLQ G-----PGVSYIVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLYETV---PGVRG--TWKKKAPNKS LASILG-RSNLRFAGISIAVNISTEGLNLSIPTSRQQVIAN----HHMQAISFASGGD-----ADTTDYVAYVAK--DPI NQRACHILECCEGLAQSVIST-------VGQAFELRFKQF-------------LHSPP---------------------- ------------------KVAAPPDRL---------LVGTEEPAWGGEEEQ-----------EHNYYNSIPGKEPPLGGL QDSRIREAGATGQLSTQININGQ-------WSQVGSPARKPAV-----------------SHSCSQWDLED--------- ----QAQASEGFPLTNGRAFG-----VRDYEEHMYVNTQNLDGLVA---DKE---------PYMIPEDSPKKDLFDMR-- ----------------PFEDALKLHESSLSAS------------QSLEDQWPSPPTRRAPVAPTEEQLRGEPWYQGKMSR REAEKLLQRDGD----------------------------------FLVRDSITNPGQ---------YVLTG-MHKGQPK HLLLVD--------PEGV----VRTKDVLFESISHLI------------SYHLHNQQPILAAESE----LHLRQVVPRKV -------------- >Danio_rerio_SHC2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------MNRRTRVEG------------------------------------------------- ---------------------------------------------------IWLGDNFTQKGSFINKPSQGWLHPDKKIS S-----TGASYIVRYMG-------CIEVLKSMRSLD--FSTRTQ---VTREAINRLCESV---PGGKT--AWKKKTTNKT LQSIMG-KSNLRFAGMSIGVNISIDGLSLLVPTTR-QVIAH----HPMQSISFASGGD-----SDTPDYVAYVAK--DPV NQRACHILECCDGLAQNVIST-------IGQAFELQFKQY-------------LHSPP---------------------- ------------------KAIPAMDSHAEYPNILSRNIRTEESAWGEDEES----------SEHDYYNSIPGKEPPVGGV VDSRLRPP------AGLLGHVHTHPQ--SKTSQMGSPAKRDAN-----------SLPATHLCYEVHWDTENNRS------ ----SSLTSDGYLRADGHPPG-----SRDYEEHLYVNTQNLDNLE-------AS-------VVGRRPESPKKDIFDMR-- ----------------PFEDALRLHEASG--------------VCVLEDKWPSPPRRRAPVAPTEDQLRREMWYHGRMSR RDAENLLGRDGD----------------------------------FLVRDSATNPGQ---------YVLTG-MQCGLPK HLLLVD--------PEGV----VRTKDMLFESISHLI------------NYHLTNKLPIVAAESE----LHLQQVVCRKI -------------- >Takifugu_rubripes_SHC2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MLLKPKYDRFRNESVTSSDDLMQSLAMSSKVVATPVVPSSAPSLPLPPLPPLD PGARSSLIPKMPQWKFSN--SLLSRSPSNTGSGSNSS----KDSGK------------------AAAAPSHAPVPPSSS- ---------------------SPQ----------------------RSSTMSSAGG---PKGSFIHKPSQGWLHPDKKIA G-----PGASYIVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLCEVV---PGGRG--AWRKKSTNKA LQTVMG-KSNLRFAGMSIAVNISIDGLSLLIPTTR-QVIAH----HPMQSISFASGGD-----TDTPDYVAYVAK--DPV NQRACHILECSDGLAQGVIST-------IGQAFELQFKQY-------------LHSPP---------------------- ------------------KTLASVE----------RSVRTEEPIWGEEESF----------SDHNYYNSIPGKEPPIGGV VDSRLRGVP----QNCIMRGQDTSEF--LRRNQASYPSGQ--------------------LCYELHWDTETTSS------ ----SGLTSDGYLCADGQSAG-----GKDYEEHQYVNTQNLDNLT--SQGAEGP-------RAGRAPDSPLKDIFDMR-- ----------------PFEDALKLHEACAGAAGP--TAAAAGGTQVLEDQWPSPPRRRAPVAPNEEQLRREPWYHSRMSR RDAERLLIRDGD----------------------------------FLVRESTTNPGQ---------YVLTG-MHCGLPK HLLLVD--------PEGV----VRTKDMLFDSINHLI------------AYHLKNELPIVAAESE----LHLKQAVRRKP -------------- >Tetraodon_nigroviridis_SHC2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------LRAAPPGMLLKPKYDRFRNESVTSSDDLMQSLAMSSKVVATPVVPSSAPSLPLPPLDDAT T-TFCMLIPKMPQWKFSN--SLLSRSPSNSSSGSSSS----KDSGK------------------AAAAPSQAPVAPTSSP Q-----------------RNSTMSSAGGP---------------VTRVEGMWLAGEDFTQKGSFIHKPSQGWLHPDKKIA G-----PGASYIVRYMG-------CIEVLKSMRSLD--FNTRTQ---VTREAINRLCEAV---PGGRG--AWRKKSMNKA LQTVMG-KSNLRFAGMSIAVNISIDGLSLLIPTTRQQVIAH----HPMQSISFASGGD-----TDTPDYVAYVAK--DPV NQRACHILECSDGLAQSVIST-------IGQAFELQFKQY-------------LHSPP---------------------- ------------------KSMASVE----------RSARAEEPIWGEDEGF----------SDHDYYNSIPGKEPPIGGV VDSRLRGS------GAPLGHV--------HSQPLGCTAAQ--------------------VTLQTD-DVNGMGS------ ----PARRDQASYPPDGQSAG-----SKDYEEHQYVNTQNLENLT--SLGAEGP-------RGGRAPDSPKRDIFDMR-- ----------------PFEDALKLH----------------------------PPRRRAPVAPNEEQLRRETWYHSRMSR RDAERLLIRDGD----------------------------------FLVRESTTNLGQ---------YVLTG-MHCGLPK HLLLVD--------PEGV----VRTKDMLFDSISHLI------------AYHLKNELPIVAAESE----LHLKQAVRRKQ -------------- >Gasterosteus_aculeatus_SHC2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MPQWKFSN--SLLSRSPSNSSSSSGSS----KDSGKAAAPQTSSSHSSSSHRHLAAVLTSCDPGCVTPC- ---------------------SLQAMRGQRVVAASSGSRSGMNRRTRVEGMWLGGEDFTQKGGFIHKPSQGWLHPDKKIA G-----PGASYVVRYMG-------CIEVLKSMRSLD--FNTRTQ---VTREAINRLCDIV---PGGKG--AWRKKAQNKA LQSVMG-KSNLRFAGMSIAVNISIDGLSLLIPTTR-QVIAH----HPMQSISFASGGD-----TDTPDYVAYVAK--DPV NQRACHILECSDGLAQGVIST-------IGQAFELQFKQY-------------LHSPP---------------------- ------------------KTMASAE----------RCARTEEAMWAEDEDF----------SQHDYYNSIPGKEPPVGGL VDSRLRPS------GALLGHI--------HTQPQSKTAAQQTGSPGRREQA---SYPPGQLCYELHWDTETTGS------ ----SGLTSDGYLCADGQPPG-----SRDYEEHQYVNTQSLENLDVLAQGPNGH-------RGSRAPESPKKDLFDMR-- ----------------PFEDALKLHEACGGPA----AGAG---VRVLEDQWPSPPRRRAPVAPNEDQLRRETWYHSRMSR RDAEKLLVRDGD----------------------------------FLVRESTTNPGQ---------YVLTG-MHCGLPK HLLLVD--------PEGV----VRTKDMLFESISHLI------------AYHLKNELPIVAAESE----LHLKQVVRRKQ -------------- >Oryzias_latipes_SHC2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MPQWKFSN--SLLSRSPSNSSSSSNSS----KDSGKAAG---APSQASS---TLAAVLNSCDPVCVTPC- ---------------------SLQAIRGQRAVAAAN-SAAG------------AAEDFSHKGNFINKPSQGWLHPDKKIA G-----QGASYIVRYMG-------CIEVLKSMRSLD--FNTRTQ---VTREAINRLCEAV---PGGRG--VWRKKAFNKA LQTVMG-KSNLRFAGMSIAVNISVDGLGLLIPTTR-QVIAH----HPMQSISFASGGD-----SDTPDYVAYVAK--DPV NKRACHILECSDGLAPSVIST-------IGQAFELQFKQY-------------LHSPP---------------------- ------------------KSMGSLE----------RSVRPEEPVWGDDEDP----------SEHDYYNSIPGKEPPIGGV VDSRLRPA------GALLGHV--------HTQPPSKQAPQ------------------------LHWDTDMTCS------ ----SGETPDGYLCADGQPTG-----IKDYEEHQYVNTQSLEHLD--AQGADGQ-------RGP--NDSPKKDLFDMR-- ----------------PFEDALKLHKACGGAG----SQAGGGVVPILEDQWPSPPRRRAPVAPNEEQLRREPWYHSRMSR RDAEKLLVRDGD----------------------------------FLVRESTTNPGQ---------YVLTG-MHCGLPK HLLLVD--------PEGV----VRTKDMLFESISHLI------------SYHLKNGLPIVAAESE----LHLKQVVRRKQ -------------- >Caenorhabditis_elegans_SHC2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------MLNVEPSFAEELR S-----SGVSLSATYLG-------SVPVVESINVMVS--EMRVQ---VVSECIQHVAATVG---------VTAAREINPV VSRVIG---EVKKENFPVDINISSKMIKIIK-QSR--LIQR----HPFSFFSFGAQGQKG---TDTELMFGYIAKNKDGT DRRCHVVFIEDVHKLIDVLTTAI-----NVNTFDAQANAS---------------------------------------- ----------------------------------------------------------------TSNDGFTVPAPPMRHR -------------------------------------------------------------------------------- -------------------------------------------------------------------SSLHRQSFVSN-- ----------------------------------------------------------CRAPTVTEDVVGKVWYHGNLSR EDAQALLKTEGD----------------------------------FLVRQSDHTPGK---------YVLSGRTAENEHK HLILLD--------NHNR----VRTRDRTFSNISELI------------DYHVNNGMAVRSEGRDRETSLNLIRPVPCPG SDDIE--------- >Homo_sapiens_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGG------------KVSAARATPAAAPYLVSGEALRKAPDDG PGSLGHLLHKVSHLKLSSS-G----LRGLSSAARERAGARL---------------------SGSCSAPSLAAPDGSAP- -------------------SAPRAP-AMSAARKGRP------------------------GDEPLPRPPRGAPHASDQVL G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFKKRKPPSKM LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPT---------------------- ------------------KIPALHDRM----------QSLDEP-WTEEEGDG---------SDHPYYNSIPSKMPPPGGF LDTRLKPR------PHAPDTAQFA-----GKEQTYYQGRHLGDT----------------FGEDWQQTPLRQG------- -------SSDIYSTPEGKLHV-----APTGEAPTYVNTQQIPPQAWPAAVSSAE-------------SSPRKDLFDMK-- ----------------PFEDALKNQP------------LGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSR KEAEGLLEKDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NHHLESSLPIVSAGSE----LCLQQPVERKQ -------------- >Gorilla_gorilla_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGG------------KVSAARATPAAAPYLVSGKALRKAPDDG PGSLGHLLHKVSHLKLSSS-G----LRGLSSAARERAGARL---------------------SGSCSAPSLAAPDGSAP- -------------------SAPRAP-AMSAARKGRP------------------------GDEPLPRPPRGAPHASDQVL G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFKKRKPPSKM LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPT---------------------- ------------------KIPALHDRM----------QSLDEP-WTEEEGDG---------SDHPYYNSIPSKMPPPGGF LDTRLKPR------PHAPDTAQFA-----GKEQTYYQGRHLGDT----------------FGEDWQQTPLRQG------- -------SSDIYSTPEGKLHV-----APTGEAPTYVNTQQIPPQAWPAAVSSAE-------------SSPRKDLFDMK-- ----------------PFEDALKNQP------------LGPMLSKAASVECISPVSPTAPDAKMLEELQAKTWYQGEMSR KEAEGLLEKDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NHHLESSLPIVSAGSE----LCLQQPVERKQ -------------- >Macaca_mulatta_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGG------------KVSAARATPAAAPYLVSGEALRKAPDDG PGSLGHLLHKVSHLKLSSS-G----LRGLSSAARERAGARL---------------------SGSCSAPSLAAPDGSAP- -------------------PAPRAP-AMSTARKGRP------------------------GDEPLPRPPRGAPHASDQVL G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFKKRKPPSKM LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPT---------------------- ------------------KIPALHDRM----------QSLDEP-WTEEEGEG---------SDHPYYNSIPSKMPPPGGF LDARLKPR------PHAPDTAQFA-----GKEQTYYQGRHLGDT----------------FGEDWQQAPFRQNE------ ----RQGSLDIYSMPEGKLHV-----APTGEAPTYVNTQQIPPQAWPTVVSSAE-------------SSPRKDLFDMK-- ----------------PFEDALKNQP------------LGPVLSKAASVECISPVSPRAPDAKMLEDLQAETWYQGEMSR KEAEGLLEKDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NHHLESSLPIVSAGSE----LCLQQPVERKQ -------------- >Mus_musculus_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MSATRKSRA------------------------GDEPLPRPPRGAPHTSDQVL G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---VTREAISRVCEAV---PGAKG-ALKKRKPPSKM LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPS---------------------- ------------------KVPALQDRM----------QSLDEP-WTEEEGDG---------PDHPYYNSVPTKMPPPGGF LDARLKGR------PHAPEAAQFA-----GKEQTYYQGRHLGDT----------------FGEDWQRAPTRQG------- -------SLDIYSTAEGKTHM-----VPVGETPTYVNTQPVPPQVWPAATSSTE-------------SSPRKDLFDMK-- ----------------PFEDALRNQP------------LGPMLSKAASVECISPVTPRAPDARMLEELNAEPWYQGEMSR KEAEALLREDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NYHLESSLPIVSAGSE----LCLQQPVERKP -------------- >Rattus_norvegicus_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLPRTKYNRFRNDSVTSVDDLLHSLSVSGSGG------------KVS---AEPAASPYLVSGEALRKAPDDG PGSLGHLLHKVSHLKLSSS-G----LRGLSSAARERAGARL---------------------SGSCSAPSLAAPDGGSAT -----------------PGSRAPAA-SMSATRKSRA------------------------SDEPLPRPPRGAPHASDQVL G-----SGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---VTREAISRVCEAV---PGAKG-AFKKRKPPSKM LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPS---------------------- ------------------KIPALQDRM----------QSLDEP-WTEEEGDG---------PDHPYYNSVPNKMPPPGGF LDARLKAR------PHAPDAAQFS-----GKEQTYYQGRHLGDA----------------FGEDWQRAPTRQG------- -------SLDIYSTPEGKAHM-----VPVGETPTYVNTQPVPPQVWPAATSSTE-------------SSPRKDLFDMK-- ----------------PFEDALRNQP------------LGPVLSKAASVECISPVTPRAPDAKMLEELNAEPWYQGEMSR KEAEALLQEDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK HLLLVD--------PEGT----VRTKDRVFDSISHLI------------TYHLESSLPIVSAGSE----LCLRQPVERKP -------------- >Canis_familiaris_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------MRSLD--FSTRTQ---ITREAISRVCEAV---PGTKG-AFRKRKPPSKM LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPS---------------------- ------------------KVPAFHDRM----------QSLDEP-WTEEEGDG---------SDHPYYNSIPSKTPPPGGF VDVRLHAR------PHAPDTAQFA-----GKEQTYYQGRHLGDP----------------FGEDWQQTPVRQG------- -------SLDIYSTPEARVPA-----AP-GEAPTYVNAQHIPVQATPASGSSTE-------------SSPLKDLFDMK-- ----------------PFEDALRNQS------------LGPVLSKAASVECISPVTPRAPDAKMLEELEGEPWYQGEMSR KEAEGLLKNDGD----------------------------------FLVRKSATNPGS---------FVLTG-MHNGQAK HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NHHLENSLPIVSAGSE----LCLQQPVEKTL -------------- >Myotis_lucifugus_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLPRTKYNHFKKDSVTSVDDLLHLS-VSGGSK------------VSAARAAPAAAAPYLVSGDALRRAPDDG SGSRGHLLHKVSHLKLASS-G----LRGLS-AARERAGARL---------------------SGSCSAPSLAAPDGSAP- -------------------PGPRAP-AMRAARKGRP------------------------GEE----PPPSAPPASDQVL G-----AGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFRKRKPPSKM LSSILG-KSNLQFAGMSISLTISTASLNLRTSDSK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECCDGLAQDVIGA-------IGQAFELRFKQY-------------LRCPS---------------------- ------------------KVPALHDRM----------QSLDEP-WTEEEGAG---------SDHPYYNSIPNKAPPAGG- VDARLKAR------PHGPDSAPFS-----GKEQTYYQGRHVGEP----------------FGEDWQQTPARQG------- -------SLDTSSMPGGTAPA-----APTGEAPTYMNTPHFPPQAGPAAGSSAE-------------SSPRKDLFDMK-- ----------------PFEDALKNQP------------VGPVLSKAASVECISPVSPRAPDAKMLEELKAELWYQGQMSR KEAEGLLKRDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHDGQAK HLLLVD--------PEGT----IRTRDRIFDSISHLI------------NHHLANRLPIVSAGSE----LCLQQPVERNP -------------- >Pteropus_vampyrus_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------------RKADDG PGSLGQLLHKVSH-KLSSS-G----LRGLS-AARERAGARL---------------------SGSCSAPSLAAPDGSAP- -------------------PGPRAP-AMRASRKGRP------------------------GDE----PPPRASPASDQVL G-----AGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFRKRKPPSKM LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECCDGLAQDVISS-------IGQAFELRFKQY-------------LQCPS---------------------- ------------------KISAFHDRM----------QSLDEP-WTEEEGDG---------SDHPYYNSIPSKTPPPGGF VDARLKVR------SHVPDTAQFA-----GKEQTYYQGRHLGEL----------------FGEDWQQTPIRQG------- -------SVDIYSMPEGKAHV-----APTGEAPTYVNTQHFPLQAGPSASSSAE-------------SSPRKDLFDMK-- ----------------PFEDALKNQS------------IGPVLSKAASVECISPISPRAPDAKMLEELKAEPWYQGEMSR KEAEGLLKRDGD----------------------------------FLVRKSTTNLGS---------FVLTG-MHDGQAK HLLLVD--------PEGT----IRTKDRIFDSISHLI------------NHHLENSLPIVSAGSE----LCLQQPVERNL -------------- >Gallus_gallus_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLQRTKYNRFRNDSVTSVNDLIHNLSMNSKVS---------------AAATASAASSYLVTPEVLRKDQEDG PTTLCTLIHKVSHLKFSNA-GSLLGIKNLSSAVKELAVSKL---------------------QGSSSASSSAAEASDNAC NLVSATSCSQQDISKMSVGKKARSEEMHPGDEDWNQ------------------------RSSIVDKPSQGWLHLSEKIL G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FNTRTQ---ITREAISRVCEAV---PGAKG-AFKKRKPPSKV LSSILG-KSNLQFAGISIMLNISTTSLNLMTPDMK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECCNGLAQDVIST-------IGQAFELRFKQY-------------LQCPS---------------------- ------------------KMPTFHDRM----------QSFDEP-LMEEESAA---------AEHPYYNNIPNKMPPPGGF INARLKAKI-----PTAADTAQFAA--GVRREKIYYQNRHLGDK----------------FNEDWHEETVKQG------- -------PLDIYSMPEGKSEA-----TARAEMPMYVNAQHINMETLLALQADAESD-ISGNTDSTKESSPEKDLFDMKLE ----------------PFEDALKNQT------------SEPVLSKLTSVECTSPLLCRAADWTRTEDLSIEPWYQGEMSR KEAEQLLKKCGD----------------------------------FLVRKSTTNPGS---------YVLTG-MQNGQAK HLLLVD--------PEGT----VRTKDRVFDSISHLI------------NHHLENNLPIVSSGSK----LCLQQPAERKH -------------- >Xenopus_tropicalis_SHC3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLQRTKYNRFKNESVTPVDDLLHNLSMNSKVT---------------TVAGNPASPPCSAPPDVLQKDQENG PTTLCTFIHKVSNLKLSSS-GSLLGIKNLSSAVKELTGSKL---------------------QGSSPALSIAAGATENTC NLVS-TPCSQQDLNKMSTG-KKTPEEMHQGGEDWNQ------------------------SSSFVNKPSRGWLHSNEKIL G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FNTRTQ---ITREAFNRVCEAV---PGTKG-VFKKRKPANKN LSSILG-KSNLQFAGMSITLNISTTSLNMMTPDTK-QIIAN----HHMQSISFASGGD-----PDATDYVAYVAK--DPV NRRACHILECCDGLAQDVIST-------IGQAFELRFKQY-------------LQCPS---------------------- ------------------KIPVFPDRM----------QSLDDPLWQEEDGMT---------TEHQYYNSIPNKMPPPGGI IDERLKTHI-----SNQGDNTQS-----VPLEQSYYQGRHLVEK----------------SCENFQQTVKRQA------- -------SLDIYSLPEGKSSI-----NQTSNAPTYVNTQHINKKTLGAIQKSADSI-LCKSVDSSRDISPRKDIFDMK-- ----------------PFEDALKNQ---------------PVLSKDASVDCSSPLLSRAAILTINEELRSEPWYVGEMCR REAEKLLKRDGD----------------------------------FLVRKSINNPGS---------YVLTG-MHNGLAK HLLLVD--------PEGT----VRTKDRVFDSIGHLI------------NHHLENNLPIVSSGSE----LCLKQPMEGKP -------------- >Danio_rerio_SHC3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLHRAKYNRFRNESVTSVDELLHGLSMNAKVSAVP-------PSPPVGDPPYAPPADPDPAEESG------- --TLCTLINKVSNLKFTNS-SGLLGIKGLPSAVKDLAVSKLQGGAA----------------AGASSSPASSTLAAASPL E------------------PGSTSSGKKGRMEESQPSGEGWSL---------GGTGAAGCGG-LVNKPSHGWLHSSEKIS G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FTTRSQ---ITRGLFNILLQMT---TGSDGEVINGDETPSKL LSSILG-KSNLQFAGMSINLNISTSSLNLMTPDSK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECSDGLAQDVIST-------IGQAFDLRFQLY-------------LQCPSS--------------------- ------------------KPSSIHDRV----------MSTDEPPWTEEGDET---------ADHHYYNSIPGKMPPPGGF IDARLTNQ-------SQDSSQGAG------VDQTYYQGRPMFIQ----------------QEKTFNCMFNNK-------- ------RSCDIYSLPEVKAQP-----PKAGEVPTYVNTQHIDTQVLAALQAETETN-ADSSTTGAPKDSPRKDLFDMKP- -----------------FEDAIMTQ-------T----PAASELHKAASVDNSSPLLMRAAALRAHEELEDQRWYHGEMSR RQAEKLLLHDGD----------------------------------FLVRKSTTNPGS---------YVLTG-MHNGLAK HLLLVD--------PEGT----VRTKDHIFESISHLI------------GHHRDNNLPIVSAGSE----LCLKQPVDRKQ -------------- >Takifugu_rubripes_SHC3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLHRTKYNRFRNESVTSVDELLHGLPMNPKVSASP----ETSYTPPTEVQSFSTATASSTPACLGSDHLEDG GTTLCTLINKVSGLKFSNS-GSLLGIKGLPSAVKDLAVSKL---------------------QAASSSGGSACGSHSVP- --------------------CSQLEPAVGMSKKSRLDELQLG------------------------KPSRGWVHSSDKIS G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FTTRSQ---ITREAISLVCEAV---PGTKG-ALRKRKPPSKT LSSILG-KSNLQFAGMSINLNISTSSLNLMTPDGK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECSDGLAQDVIGT-------IGQAFDLRFQQY-------------LQCPSS--------------------- ------------------KISSPHDRV----------LNMEELTWTEEEEES---------TEHPYYNNIPGKMPPPGGI VDTRLTNQN-----AAQDGCQMGPG----SIDQTYYQGRHCGEN----------------WGDDRKPIFIQQ-------- ------GSFDIISLPESKGQA-----QR-AEMPAYVNTQQIDAQVLAALQAEGENV-TKGLASAPAKESPQKDLFDMKP- -----------------FEDAIQSE----GPEH----SQAAGLHKAASVDNASPLLVRSLAFRAQEELEGQTWYHGIMSR REAEKLLQDDGD----------------------------------FLVRKSTTNPGS---------YVLTG-MHNGLAK HLLLVD--------PEGT----VRTKDHVFDSILHLI------------GHHRDNNLPILSAGSE----LFLLQPVGRKQ -------------- >Tetraodon_nigroviridis_SHC3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLHRTKYNRFRNESVTSVDELLHGLPMNPKVSASP----ETSYTPTAEVQSSSTTTASSTPASLGSNHLEDG GTTLCTLINKVSGLKFSNS-GSLLGIKGLPSAVKDLAVSKLQVGGGS---------------GSCGSGSPSPCGRLRVRP P------------------RSPLLTAGAGRRHEQESVS----------------------------KPSRGWLHSSDKIS G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FTTRSQ---ITREAISLVCEAL---PGTKG-ALRKRKPPSKT LSSILG-KSNLQFAGMSINLNISTNSLNLMTPDGK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NRRACHILECSDGLAQDVIST-------IGQAFDLRFQQY-------------LQCPSG--------------------- ------------------KISSPHDRV----------LNMEELTWTEEEEES---------AEHPYYNNIPGKMPPPGGI IDTRLTSQN-----TAQDGCQMGPG----SIDQTYYQGRHCAEN----------------WGDDRKPVFIQQ-------- ------GSFDVISLPESKVQA-----QK-VEMPAYVNTQQIDAQVLAALQAE-------------AKESPQKDLFDMTEP -----------------FEDAIHSQ----GPEP----SQAAALSKAASVDNASPLLVRSLAFRAQEELEGQEWYHGIMSR REAEKLLRDDGD----------------------------------FLVRKSTTNPGS---------YVLTG-LHNGLAK HLLLVD--------PEGT----VRTKDHVFDSILHLI------------GHHRDNNLPILSAGSE----LFLLQPVGRKQ -------------- >Gasterosteus_aculeatus_SHC3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLHRTKYNRFRNESVTSVDELLHGLSMNPKVSATPQSAAETSYTPPTEVQPSAAAACS-ISTGHGSDHLEDG GTTLCTLINKVSGLKFSNS-GSLLGIKGLPSAVKDLAASKLQGGGGLGS-------------GGGGGGGGGVPAAATS-- ----------------------------------------------------GDWNPGGGGGGLVIKPSRGWLHSSEKIS G-----PGVTYVVKYLG-------CIEVLCSMRSLD--FTTRSQ---ITREAISLVCEAV---PGTKG-ALRKRKPPSKA LSSILG-KSNLQFAGMSINLNISTSSLNLMTPDCK-QIIAN----HHMQSISFASGGD-----PDTTDFVAYVAK--DPV NRRACHILECSDGLAQDVIRT-------IGQAFDLRFQQY-------------LQCPSG--------------------- ------------------KLSSTHDRV----------LNMEELPWTEEEEES---------AEHPYYNNIPGKMPPPGGF IDTRLTTQN-----AAADG---CG---VQLLDQTYYQGRHCGEN----------------WGDERKVIFIQQ-------- ------GSFDISGLPESKGQA-----PKTGEMPAYVNTQQIDAQVLAALQAEAE-------------HCPQKDLFDMKP- -----------------FEDAIQSQ--SHPPSQ----PQVAAIHKTASVDNCSPLLARSVAFRAQEELQGQMWYHGQMSR RDAEKLLKEDGD----------------------------------FLVRTSTTNPGS---------DVLTG-MHNGLAK HLLLVD--------PEGT----VRARRA---------------------------------------------------- -------------- >Oryzias_latipes_SHC3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MLHRTKYNRFRNESVTSVDELLHGLSMNPKVSATPHSAAETPYTPPTEVQSSSGTPLSNAPTSHGSDHLEDG GTTLCTLINKVSNLKFSNS-GSLLGIKGLPSAVKDLAVSKLQGGGGSGS-------------SSGSSPSAATAAAASVP- --------------------CSQQEPALSMSKKSRLDELLPSG---------EDWNPGGGGG-LVSKPSRGWLHSNEKIS G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FTTRSQ---ITREAISLVCEAV---PGTKG-ALRKKKPPSKA LSNILG-KSNLQFAGMSINLNISTSSLNLMTPDCK-QIIAN----HHMQSISFASGGD-----PDTTDFVAYVAK--DPV NRRACHILECADGLAQDVIST-------IGQAFDLRFQQY-------------LQCPSN--------------------- ------------------KPSSTHDRI----------LNMEELPWTEEEEES---------TDHPYYNNIPGKMPPPGGF IDTRLTNQN-----AASEGSQVCGKMATGSVDQMYYQGRHC-EG----------------WAEERRPIIIQQGL------ ------GSFDIVGFPESKSQA-----AKTGEMPTYVNTQQIDAQVLAALQAEAENV-MKGMA-ATTKDSPQMDLFDMKP- -----------------FEDAIQSHPPSQGQTQ----TPVSNLHKAASVDNSSPLLVRSLAFRAQEELEDQTWYHGKTSR RDAEKLLKQDGD----------------------------------FLVRKSTTNPGS---------YVLTG-MHSGLAK HLLLVD--------PEGT----VRTKDHIFDSISHLI------------GHHRDNNLPIVSAGSE----LCLLQPVARKQ -------------- >Homo_sapiens_SHC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MRERGQDSLAGLVLY VGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVG----------------NKGSPQPPHPALAPHLPTEDATLPSQES PTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGP------------SSPETSLSRSGTAPPPQ -------------------QDLVGHRATALTPDSCP----------------------LPGPGEPTLRSRQDRHFLQHLL G-----MGMNYCVRYMG-------CVEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---PGANG-AIKKRKPPVKF LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNLDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NQRACHILECHNGMAQDVIST-------IGQAFELRFKQY-------------LKNPS---------------------- ------------------LNTSCESEE----------VHIDSHA----EERE----------DHEYYNEIPGKQPPVGGV SDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNVHPRGVQSQ------ --------RDTSLLKHTCRVD-------LFDDPCYINTQALQSTPGSA-----------------GNQRSAQPLGSPW-- ----------------HCGKAPET----------------------VQPGATAQPASSHSLPHIKQQLWSEECYHGKLSR KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN NPALLHSNK----- >Gorilla_gorilla_SHC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MRERGQDSLAGLVLY VGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVG----------------NKGSPQPPHPALAPHLPTEDATLPSQES PTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGP------------SSPETSLSRSGTAPPPQ -------------------QDFVGHRATALTPDSCA----------------------LPGPGEPTLRSRQDRHFLQHLL G-----MGMNYCVRYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---PGANG-AIKKRKPPVKF LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNLDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NQRACHILECHNGMAQDVIST-------IGQAFELRFKQY-------------LKNPS---------------------- ------------------LNTSCESEE----------VHIDSHA----EERE----------DHEYYNEIPGKQPPVGGV SDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNVHPRGVQSQ------ --------RDTSLLKHTCRVD-------LFDDPCYINTQALQSTPGSA-----------------GNQSSVQPLGSPW-- ----------------HCGKAPET----------------------VQPGATAQPASSHSLPHIKQQLWSEECYHGKLSR KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN NPALLHSNK----- >Macaca_mulatta_SHC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MRERSQDSLAGLVLY VGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVG----------------NKGSPQPPHPALAPHLPAEDAALPSQES PTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSSP------------SSPETSLSRSGTAPPPQ -------------------PDLVSHRATALTPDSCP----------------------LPGPGEPPLRSRQDRHFLQHLL G-----MGMNYCVRYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---PGANG-AIKKRKPPVKF LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNLDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NQRACHILECHNGMAQDVINT-------IGQAFELRFKQY-------------LKNPS---------------------- ------------------LDTSCESEE----------VRIDSHA----EESE----------DHEYYNEIPGKQPPAGGV SDMRIKVQATEQMAYCPIRCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNVHPRGVQSQ------ --------RDTSLLKHTCRVD-------LFDDPCYINTQALQSTLGSA-----------------GNQSSAQPLGSPW-- ----------------HCGKAPET----------------------VQPGATAQPASSHSLPHIKQQLWSEECYHGKLSR KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN NPALLHSNK----- >Canis_familiaris_SHC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MRRRGRDSLAGLVLC VGLVGHPGMLHRAKYSRFRNESVTSLDESGPGGGAGG---------------DKGSPQPPYPALAPHLPPEDATLAAQES PTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKLQESQDPAPSSP------------APPEAGLTRAGPAPLPQ Q------------------PGPVGHRATVLTPEACP----------------------LPGAGQPTPGSRQDRHFLQHLL G-----MGMNYYVRYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---SGANG-AVKKRKPPVKF LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNIDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NQRACHILECRSGMAQDVIST-------IGQAFELRFKQY-------------LKNPS---------------------- ------------------LNTSCESEG----------VPIDDHA----EERE----------DHEYYNEIPGKQPPAGGV SDVRIKVQATEQMAYCPIRCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNAQERGVQSH------ --------RDASLMKHACRVD-------FFNDPCYINTQAFQSTLGSA-----------------PNQSSAHVLGSPW-- ----------------HREKAPET----------------------VQPGATAQPASSHSLPHVKQQLRSEDCYHGKLSR KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN NPGLLHSNK----- >Felis_catus_SHC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MRKRGQDSLAGLVLY VGLFGHPGMLHRAKYSRFRNESITSLDESSPGGSVG----------------SKGSAPPPYPTLAPHLPAEDATLASQES PTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKLQESQDPAPSSP------------ASPETSPNRAGSAPLPQ -------------------PDLLGHRAAALTPDACP----------------------LPGPGEPTPGSRQDRHFLQHLL G-----MGMNYYVRYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---SGANG-AVKKRKPPVKF LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNIDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NQRACHILECRSGMAQDVIST-------IGQAFELRFKQY-------------LKNPS---------------------- ------------------LNTSCESEE----------VPLDGPA----VERE----------DHEYYNEIPGKQPPAGGV SDVRIKDQATEQMAYCPIRCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNAQERGGQCQ------ --------RDAALMKHTCRVD-------FLNDPCYINTQGLQSTLGSS-----------------PNQSSAHSLGSPW-- ----------------HRQKAPET----------------------VQPGATAQPASSHSLPHIKQQLRNEDCYHGKLSR KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN NPGLLHSNK----- >Myotis_lucifugus_SHC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MRERSPDGLAGLALH VGLFGHPGMLHRAKYSRFRNESVTSLDEGSPGGSVG----------------NKGSPQPPYPALAPHLLAEDAPSPSQES PTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKLQESQDPAPSSP------------ASPENSLNRSGSAPPQQ -------------------RDVVGRRASALTPDACP----------------------LPGPGDPTPGSRQDRHFLQHLL G-----MGMNYCVKYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---PGANG-ATKKRKPPVKF LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNLDNH-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV NQRACHILECRNGMAQDVITT-------IGQAFELRFKQY-------------LKNPS---------------------- ------------------LNTSCESEE----------VHIDGHA----DERD----------DHEYYNEIPGKQPPMGGV SDVRVRVQATEQMAYCPIRCEKLCYLPGNSDCSSVYENCLEQSR-----------------AIGNAHERAVPSQ------ --------RDTALMKHTCRVD-------LFDDPCYINTQALHSALGST-----------------RNPGSAQLLGSLW-- ----------------HREKAPET----------------------VQPGATAQPASSRSLPYIQQQLRSEDCYHGKLSR KAAENLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQ-K HLLLVD--------PEGK----VRTKDHIFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRRDN IPGLLHLNK----- >Pteropus_vampyrus_SHC4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MRERSQDSLAGLVLY VGLFGHPGMLHRAKYSRFRNESITSLD