>Homo_sapiens_CREB3 -------------------------------------------------------------------------------- --------------------------------MELELDAGDQ-------------------------------------- ------------------------------------------------------------------DLLAFLLEESGDLG TAPDE---------------------------AVRAPLDWALPLSEV----------P-----SDWEVDDLLCSLLSPPA S-----------------------------------------------------------------------------LN ILSSSNPCLVHHDHTYSLPRETVSMDLGESE------------------------------------------------- -------------------------------------------------------------------------------- ----------------------ISLGRTGFMGLAIHTFPFAESESCRKEGTQMTPQH----------------------- -------------------MEE-LAEQE---------------------------------------------------- ------------------------------------------------------IARLVLTDEEKSLLEKEGLILPETLP LTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLES-RVLKYTAQNMELQNKVQLLEEQ-NLS-LLDQLRKLQAMVIE ISNK-----TSSSS-TCILVLL----------------------------VSFCLLLVPAMYSSDT-------------- ----------RGSLPAEHGVLS---------------------------------------RQLRALPSEDPYQLELPAL QSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYM-------------------PQAPSAEPPLEWPFPDLFSEPLCRGPIL PLQANLTRKGGWLPTGSPS-VILQDRYSG--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Pan_troglodytes_CREB3 -------------------------------------------------------------------------------- --------------------------------MELELDAGDQ-------------------------------------- ------------------------------------------------------------------DLLAFLLEESGDLG TAPDE---------------------------AVRAPLDWELPLSEV----------P-----SDWEVDDLLCS------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------SESCR-PLTQMTPQH----------------------- -------------------MEE-LAEQE---------------------------------------------------- ------------------------------------------------------IARLVLTDEEKSLLEKEGLILPETLP LTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLES-RVLKYTAQNMELQNKVQLLEEQ-NLS-LLDQLRKLQAMVIE ISNK-----TSSSS-TCILVLL----------------------------VSFCLLLVPAMYSSDT-------------- ----------RGSLPAEHGVLS---------------------------------------RQLRALPSEDPYQLELPAL QSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYM-------------------PQAPSAEPPLEWPFPDLFSEPLCRGPIL PLQANLTRKGGWLPTGSPC-VILQDRYSG--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Macaca_mulatta_CREB3 -------------------------------------------------------------------------------- --------------------------------MELELDAGDQ-------------------------------------- ------------------------------------------------------------------DLLGFLLEESGDLR TAPDE---------------------------SVRAPLDWELPLSEV----------P-----SDWEVDDLLSSLLSPPA SS----------------------------------------------------------------------------LN VLSNSNPCLVHHDHTYSLPREPVSMDLGESE------------------------------------------------- -------------------------------------------------------------------------------- ----------------------ISLGRTGFMGLAIHTFPFAESESCRKEGTQMTPQH----------------------- -------------------MEE-LAEQD---------------------------------------------------- ------------------------------------------------------IVRLVLTDEEKSLLEKEGLILPETLP LTKMEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLES-RVLKYTAQNMELQNKVQLLEEQ-NLS-LLHQLRKLQAMVIE ISNK-----TSSSS-TCILVLL----------------------------VSFCLLLVPAMYSSDT-------------- ----------RGSLPAEHGVLS---------------------------------------RQLRALPSENPYQLELPAL QSEVPKDCTHQWLDSSDHVLQAPGNSSCLLYYM-------------------PQAPSAEPPLEWPFPDLFSEPLCRGPIL PLQANLTRKGGWLPTGSPS-VILQDRYSG--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Mus_musculus_CREB3 -------------------------------------------------------------------------------- --------------------------MDPGGQDLLALDPGDQ-------------------------------------- ------------------------------------------------------------------DLLGFLLEESGDLW AATEP---------------------------DVKAPLDLELSPSEN----------SVQE-LSDWEVEDLLSSLLSPSV S-----------------------------------------------------------------------------RD VLGSSSSS-ILHDHNYSLPQEHVSIDLGECEM------------------------------------------------ -------------------------------------------------------------------------------- ----------------------ISCGRRELTGLAGSTFPFADTESFEKEGFHVTPLP----------------------- -------------------GEERAAEQE---------------------------------------------------- ------------------------------------------------------MSRLILTEEEKKLLEKEGLTLPSTLP LTKVEEQVLKRVRRKIRNKRAAQESRKKKKVYVVGLES-RVLKYTAQNRELQNKVQRLEEQ-NLS-LLDQLRKLQAMVIE IANK-----TSSGS-TCVLVLV----------------------------FSFCLLLVPAMYSSDA-------------- ----------RGSVPAEYVVLH---------------------------------------RKLRALPSEDDHQPKPSAL SSELPMDSTHQSLDSSEHMFLVSSNFSCVLYHA-------------------PQA---EQPLHWPLWDLSSEMLFSDSNL LLQANLSESEGWQPNHSPSLVIFQGRYSG--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Rattus_norvegicus_CREB3 -------------------------------------------------------------------------------- --------------------------MDPGGQDLLALDPGDQDLLALDPGDQ---------------------------- ------------------------------------------------------------------DLLGFLLEESGDLW AATEQ---------------------------DIETPLDLELSPSEN----------SVQE-LSDWEVEDLLSSLLSPSS S-----------------------------------------------------------------------------PD VLNSSSSS-ILHDHNYSLPQEHVSIDL----------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------DPGSFEKEGFRMNPLR----------------------- -------------------VEETAAEQE---------------------------------------------------- ------------------------------------------------------LSTLILTEEEKRLLEKEGLTLPSTLP LTKVEEQVLKRVRRKIRNKRAAQESRKKKKVYVVGLES-RVLKYTAQNQELQNKVQHLEEQ-NLS-LLDQLRKLQAMVTE IANK-----TSSGS-TCVLVLL----------------------------LSFCLLLVPAMYSSDV-------------- ----------RGSVPAEYVVLH---------------------------------------RKLRALPSEDQHQPKLSAL QPELPMGSTNQ-LESSEHTFLAPSNVSCLN-HM-------------------AQT---EQPPHWPLLDLSSEMPFSGSDL LLQANLTESGGWLSTHSPSSIILQGRYSG--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Canis_familiaris_CREB3 -------------------------------------------------------------------------------- -----------------------------LSGMELALDLGDQ-------------------------------------- ------------------------------------------------------------------DLLDFLLEESGDLG AGP---------------------------------------PLSEA---------------LSEWEAEDFLSSMLSPPA S-----------------------------------------------------------------------------LN VLSSSDSCLVHHDHTYSLSQQHVSID------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------------LDGGSYGKEEAQTTPLQ----------------------- -------------------VEE-PAEQE---------------------------------------------------- ------------------------------------------------------IARLILTDEEKRLLEKEGLTLHGTLP LTKMEEQVLTRVRRKIRNKKSAQESRRKKKVYLGGLEN-RVLKYTAQNLELQNKVQLLEEQ-NLS-LLDQLRRLQAMLIQ ISNK-----TSSSS-TCVLVLL----------------------------FSFCLLIVPAMYSSDT-------------- ----------RGSLPAEHGVLS---------------------------------------RQLRALPSEDPHQLELPAL QSEVPKD-------SSDQELQAPGNSCCPLYHL-------------------PQAPGAESPLKLPLPVPSSKSPCSCPLL PLHANFTRDGGWLPTHSPTSVILQGRYSG--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Myotis_lucifugus_CREB3 -------------------------------------------------------------------------------- -----------------------------ISHMELALDPGEQ-------------------------------------- ------------------------------------------------------------------DLLGFLLGESGDLG AAPNE---------------------------VLEAPRDWELPLSEA---------------LSDWDVEDFLRSLPSPPA S-----------------------------------------------------------------------------LN IFSNSNPCLVHHDHTYSLSQEHVSID------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------------LDSGSCGKEGVQMTPLH----------------------- -------------------VED-PEEQE---------------------------------------------------- ------------------------------------------------------VVGLILTDEEKRLLEQEGLTLPGTLP LTKMEEQVLKRVRRKIRNKKSAQESRRKKKVYVGGLES-RVLKYTAQNLELQNKVQLLEEQ-NLS-LLDQLRRLQAMVIE ISNK-----TSSSSSTCVLVLL----------------------------FSFCLALVPAMYSSGT-------------- ----------RGSLPAERGVLS---------------------------------------RQLRALP----HQLELSVL QSEEPKD-------SSDHELQAPGNSCCLPSHM-------------------PQAPGTEPPLKLPLPDPFSKFASLGPIV PLHANLTREREWLPAHSPISVILQGRYSG--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Pteropus_vampyrus_CREB3 -------------------------------------------------------------------------------- --------------------------------MELALDPDDQ-------------------------------------- ------------------------------------------------------------------DLLGFLLEESGDLG AVPKE---------------------------AMEAPMSWELPLSQA---------------LSDWDVEDFLSSLQSPPA S-----------------------------------------------------------------------------LS VLSNSNPCLVHHDHTYSLPQEHVSID------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------------LDSESYGKEG-ALIPLH----------------------- -------------------VEE-PSEQE---------------------------------------------------- ------------------------------------------------------MVRLILTDEEKRLLEQEGITLPGTFP LTKMEEQVLKRVRRKIRNKKSAQESRRKKKVYVGSLES-RVLKYTAQNLELQNKVQLLEEQ-NLS-LLDQLRRLQAMVVQ IANK-----TSSSS-TCVLVLL----------------------------FSFCLLLVPAMYSSDT-------------- ----------RGRLPSEHGVLS---------------------------------------RQLRGLSE-DLHQLELPAL QPEVPKD-------SSDRELQAPGNS-CLFYLM-------------------PQALGTEPPMKLPLPDPFSKSPRPDPIL SLHANLTREGEWVPAHSSICVILQGRHSG--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Danio_rerio_CREB3_b -------------------------------------------------------------------------------- -----------------------------------MVNCMSQSPHG---------------------------------- --------------------------------------------------------------------SDSGISEDTTPP HCQSP---------------------------HDGSETDTVPSPGQE----------PLLY--SECVTESYEAQVVQTDH C----------------------------------------------------------------------------YTL PQ----DTNTLLSVRSENPESDVFIDVDDL-------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------DASMEDDDFSPELPCSLT----------------------- -------------------IEDSMQSSKLDS------------------------------------------------- ---------------------------------------------------QFQFKEIVLTDEEKRLLAKEGATIPSHMP LTKAEERTLKRVRRKIRNKQSAQESRKKKKVYVDGLEN-RVAVCTAHNQELQKKVEMLHKQ-NMS-LIEQLRKLQAMVKM STMK-----TTTTS-TCIMVFL----------------------------LSFCLIIFPSVNPFGS-------------- --------SDQKDLYASSTGMS---------------------------------------RALRSYPAIKKDNIISTSA KEVVDQDVLLVATIENNQALLSAGQN-HTPDYG---WSSPTLSLESTATP----PPTSPLRHSQISKQTPLCP--NLTGT LVHHRS-SMMARANPRRAGWSRNPPQS----------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Tetraodon_nigroviridis_CREB3_b -------------------------------------------------------------------------------- -----------CPSRSPVGSDSGIS-----DDSSTG--AGPHNLRG---------------------------------- --------------------------------------------------------------------CLS--PQGSDTD AVTSP---------------------------G-YSRGSPVPS--DP----------ALVP--EDMQTEKQEALSVQADH S----------------------------------------------------------------------------YAL LQVAAADMDALQSVRAEKPDTYVFIDLDNL-------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------VSEAVEDEL-NVLPCTLA----------------------- -------------------IEDSLQERPLSP------------------------------------------------- ---------------------------------------------------QFQFKEIVLTEEEKRLLSKEGATIPTDMP LTKAEERTLKRIRRKIRNKQSAQESRKKKKVYVDGLEN-RVAVCTAHNMELQKKVQLLQKQ-NIS-LIEQLRKLQAMVKM STLK-----ASTTS-TCVMVFL----------------------------LSFCLIIFPAVNPFGKN------------- --------TEQKELYTPSSVIS---------------------------------------RTLRSLPPESTDALP-YLA AEEEDLLLVPHAELENVKSIFAGGQNNHTPDYG--------------WSS--PSPRPASTATPHPTSPL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Homo_sapiens_CREB3L1 -------------------------------------------------------------MDAVLEPFPADRLFP---G SSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFS-NDLFSSFFDDPVLD----------------------------EK SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD SAPQSP--------------------------LVPIKMEDT--TQDAEHG--------AWALGHKLCSIMVKQEQ--SPE LP-VDPLAAPS---------------------------------------AMAAAAAMATTPLLGLSPLSRLP-IPHQA- ----PGEMTQLPVIKAEPLEVNQFLKVTP----------EDLVQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------MPPTPPSSHGSDSDGSQSPRSL---------------------- ---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG-------------------------------------- -----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSGSQ-------- ---------TVKEDPLAADGV----------------------------------------YTASQMPSRSLLFYDDGAG LWEDG-RSTLLPMEP-----PDGWEINPGGPAEQRPRDH--------------LQHDHLDSTHETTKYLSEAWPKD-GGN GTSPDFSHSKEWFHDR--DLGPNTTIKLS--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Pan_troglodytes_CREB3L1 -------------------------------------------------------------MDAVLEPFQADRLFP---G SSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFS-NDLFSSFFDDPVLD----------------------------EK SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD SAPQSP--------------------------LVPIKMEDT--TQDAEHG--------AWALGHKLCSIMVKQEQ--SPE LP-VDPLAAPS---------------------------------------AMAAAAAMATTPLLGLSPLSRLP-IPHQA- ----PGEMTQLPVIKAEPLEVNQFLKVTP----------EDLVQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------MPPTPPSSHGSDSDGSQSPRSL---------------------- ---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG-------------------------------------- -----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSGSQ-------- ---------TVKEDPLAADSV----------------------------------------YAASQMPSRSLLFYDDGAG SWEDG-RSTLLPMEP-----PDGWEINPGGPAEQRPQDH--------------LQHDHLDSTHETTKYLSEAWPKD-GGN GTSPDFSHSKEWFHDR--DLGPNTTIKLS--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Macaca_mulatta_CREB3L1 -------------------------------------------------------------------------------- ------------------HFPEHLDHFTENMEDFS-NDLFSSFFDDPVLD----------------------------EK SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD SAPQSP--------------------------LVPIKMEDT--TQDVEHG--------AWALGHKLCSIMVKQEQ--SPE LP-VDPLAAPS---------------------------------------AMSAAAAMATTPLLGLSPLSRLP-IPHQA- ----PGEMTQLPVIKAEPPEVNQFLKVTP----------EDLVQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------MPPTPPSSHGSDSDGSQSPRSL---------------------- ---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG-------------------------------------- -----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSGSQ-------- ---------TVKEDPMAADSI----------------------------------------YTASQMPSRSLLFYDDGAG SWEDG-RSALLPMEP-----PDGWEINPGGPAEQRPQDH--------------LQHDHLDNSHETTKYLSEAWPKD-GGN GTSPDFSHSKEWFHDR--DLGPNTTIKLS--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Mus_musculus_CREB3L1 -------------------------------------------------------------MDAVLEPFPADRLFP---G SSFLDLGDLNESDFLNNAHFPEHLDHFVENMEDFS-NDLFSSFFDDPVLD----------------------------EK SALL--DMELDSPAP----------------------------------------------------GIQAEHSYSLSGD SAPQSP--------------------------LVPVKMEDT--TQDVEHG--------AWALGNKLCSIMVKQEQ--SPE LP-VDPLAASS---------------------------------------AMAAAAAMATPPLLGLSPMPRLP-IPHQA- ----PGEMTQLPVIKAEPPEMSQFLKVTP----------EDLVQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------MPPTPPSSHGSDSDGSQSPRSL---------------------- ---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG-------------------------------------- -----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETYTSENNELWKKVETLET--ANRTLLQQLQKLQTLVTS K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPAFSSGSM-------- ---------TVKEDPIAADSV----------------------------------------YAASQMPSRSLLFYDDGAG SWEDG-RGALLPVEP-----PEGWELKPGGPAEQRPQDH--------------LRHDRADSIHETTKYLRETWPEDTDDN GTSPNFSHPKEWFHDR--DLGPNTTIKLS--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Canis_familiaris_CREB3L1 -------------------------------------------------------------MDAVLEPFPVDRLFP---G SSFLD-GDLNESDILNNAHFPEHLDHFAENMEDFS-NDLFSSFFDDPVLD----------------------------EK SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD SAPQSP--------------------------LLPIKMEDT--TQDVEHG--------AWVLGHTLCSVMVKQEQ--SPE LP-VDPLAASS---------------------------------------AMAAAAAMATTPLLGLNPLSRLP-VPHQA- ----PGEMTQLPVIKAEPQEVNQFLKVTP----------EDLVQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------MPLTPPSSHGSDSDGSQSPRSL---------------------- ---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG-------------------------------------- -----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSSSQ-------- ---------TVKEDPMATDSV----------------------------------------YTASQMPSRSLLFYDEGAG SWEDG-RGALLPVEP-----PDGWEINPGGPAEQRPQDH--------------LQHDHLDSTHETTKYLSEAWPKDIGGN GTSPDFSHPKEWFRER--DLGPNTTIKLS--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Felis_catus_CREB3L1 -------------------------------------------------------------MDAVLEPFPADRLFP---G SSFLDLGDLNESDFLNNAHFPEHLDHFAENMEDFS-NDLFSSFFDDPVLD----------------------------EK SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD SAPQSP--------------------------LVPIKMEDT--TQDVEQE--------AWVLGHKLCSVMVKQEQ--SPE LP-VDPLAASS---------------------------------------AMAAAAAMATTPLLGLSPLSRLP-VPHQA- ----PGEMTQLPVIKAEPQEVNQFLKVTP----------EDLVQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------MPLTPPSSHGSDSDGSQSPRSL---------------------- ---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG-------------------------------------- -----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSSSQ-------- ---------TVKEDPVAADSV----------------------------------------YTASQMPSRSLLFYDEGAG SWEDG-RSALLPVEP-----PDGWEIKPGGPAEQRPQDH--------------LQLDHLDSTHETTKYLSEAWPKDVGGN GTSPDFSHPKEWFRER--DLGPNTTIKLS--------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Taeniopygia_guttata_CREB3L1 -------------------------------------------------------------------------------- ------------------HFSENLDHFSDNMEDFS-NDLFSSFFDDPVLA----------------------------EK NPLL--DMDLDPPTP----------------------------------------------------GIQAEHSYSLSGD SAPQSP--------------------------LVPVKTEDN--ASELENG--------VWSLGPKLCSIMVKQEQNLPLD LP-ESQLPASS-------------------------------------------------IPVLNLNPLQRLP-LPEEI- ----PIEITPAPVIKAEPKEVNQFLNVPT----------DDLVQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------MPPTPPSSHGSDSDGSQSPRSL---------------------- ---------PPSSPARPAARSSTAISSS---PLLTAPHKLQG-------------------------------------- -----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETYTTENNELWKKVETLEN--ANRTLLQQLQKLQALVAG K-VSRPYKMASTQTGTCLMVL----------------------------ALCFVLILGSLMPCLPEFSSASQ-------- ---------TVKATP--APDI----------------------------------------YTTSKIQSRSLLFYDEGAG SLEES-YSSFLTMDH-----PEGWEAK----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Danio_rerio_CREB3L1_a -------------------------------------------------------------MDTILDNFASDK------L FPNSNLLDLEDLNESD-FLSNVH---FSEQMEDFSNDLFN-SFFDDHLL------------------------------A ERNPLLDMDL-DPPNP---------------------------------------------------DIQAEHSYSLSED SAPQSP--------------------------SIPIKSDDDADSEAMWSF-------------SQDLTAILVKQEPSLMS E--NCPETAPP-----------------------------------------LANSSTCSPPLTLAPPPQRNHSGEKGS- ---KGLSSNSVPAIKAEPREANQFLNVPSE----------EHLR------------------------------------ -------------------------------------------------------------------------------- ------------------------------------LPPTPPSSHGSDSDGSQSPHSLPPLSPG---------------- HLQSPHS-LPPSSPARLQARTSTAISSS---PLLTAPHKLQG-------------------------------------- -----------------------------------------------------TSGPLMLTEEEKRTLIAEGYPVPNKLP LTKTEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVENYTSENNELWKKVETLEN--ANRSLLQQLQRLQALVSG K-VPRSCKIASTQTGTCLMVV----------------------------ALCFVLVLGSLAPC-LPELSLYSS------- ---------SLSSSSSHTVKS----------------------------------------APLPSGDLYTTSQVRSRSL LFYDEGVPVEDGHR-----GLLSVERTEGVPRHVQDVKD--------------SSHKQDHSALVSRYLSEAQPESASYSN TSAAPLRPPEPHYHSRKRDPEGGAEYF----------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Takifugu_rubripes_CREB3L1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------D----------DTVQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------LPPTPPTSNHGDSDGS-----LPPSSP----------------- HLP-----LPQSSP---------AISSS---PLLTAPHKLQG-------------------------------------- ------------------------------------------------------SGPLMLTEEEKRTLVAEGYPIPNKLP LTKSEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVESYTSENSDLWRKVENLET--ANRSLLQQLQKLQTLISG KVVPHSCKIASTQTGTCLMMM----------------------------ALCFVLVLGSFSSC-LSPLSF---------- -----------PTDT----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Oryzias_latipes_CREB3L1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------KLQG-------------------------------------- ------------------------------------------------------SGPLMLTEEEKRTLVAEGYPVPNKLP LTKSEEKALKRVRRKIKNKISAQESRRKKKEYVDCLEK-KVESYTSENGDLWRKVENLET--ANRSLLQQLQKLQSLISG KVIPRSCKIASTQTGTCLMMV----------------------------ALCFVLVLGSFSPC-LSPLSL---------- ----------LSHSS----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Branchiostoma_floridae_CREB3L1 MEQYHGQQYPGDQGQGPYGDQWGYDGGWDRPSCALQDRRVYPQHLPPPNQHPAFPCILPSMTSKIDNNNPQTPRVRVILS LHQRPVRVLVVDRPVDGSTPVSAWVVRSRILSRLILTRKRRRRRFSAFPPNFGDYRHFCAGFRLKLHAMDSLAHDRKLSE LGSNDFNDILDTDVFR---------------------------------------------------LPPNDQLDDLPSD WLNGLL--------------------------DEPLIPDKPLNDVSLAPP---------PQIQAEHSYSMMSAADLAMEE SLRIKTEENDF-----------------------------------------DMADWMTSGHMDHGMMHDDPMDYDMGNT AYHMAEQMEPLDLIKIKTEPTDPDLYFHTG----------ADDLDVQ--------------------------------- -------------------------------------------------------------------------------- ------------------------------------MPPTPPSSASSDSEGGSSPRAI---------------------- ----PDSPTRP-TFSKQAGQSSGPMSPNPGQNLLTNFQKLPP-------------------------------------- ------------------------------------------------------SGPLILTEEEKRTLISEGYPIPTKLP LTKAEEKSLKKVRRKIKNKISAQESRRKKKEYVDQLEK-RVENFTHENNELRKKCNTLES--SNKTLLVQLQKLQALVN- R-VPRPCRTNATQTGTCLMVGFKHSLSCSFSLTILLYMVRGSIPGLEVLVVFFAIFLGSWSPTLYLPSMTSYL------- ---------PTPFTHSVVQSN----------------SGPNHIGLAG-------------VPHSGGGDD--YTTPNRHSS RALFAFTEEVTDDV---SHFEQGLDPVLEKLWQELPDDA--------------YAIVNNETDKPLVLSGGEEDAAFGPGT VLHPDIAAEVS-SKLISLEHRANATA------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------- >Caenorhabditis_elegans_CREB3L1 --------------------------------------------------------------------MDDDWATS---- ----GVLEKDVFISSVHDEKDTLDILKLFDNDIDGFS--DDN------FR----IK-------------------MEPND ETS----------------------------DYHGSSSG---------------------------SPSSSLSSPNEFKD EPLGLDVHFG-----------------------NSLFNAPFSPSATSSHS-------PSSYGMMHGSHSMASHQLHQQQL S-------------------------------------------------------------------------PLPSVA HFSHSHHLQHHVVQHPSQASLQMNMNQIFSGPSH---------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------QYASSSVPHTFLFKDSTIYEG----------------------- --------------MGGMGLAAAQQQLKARN------------------------------------------------- -----------------------------------KMHEMAIRQHLITDQNITANGDLVLSAEERRTLVQEGYSIPQKYP LTKSEEESLKIVRRKIKNKLSAQESRRKRKEYIDALEG-RLHCFSEENKSLKKQVHQLEA--SNRDLQQKLHQYESKEKM -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Homo_sapiens_CREB3L2 --------------------------------------------------------------MEVLESGEQG------VL QWDRKLSELSEPGDGEALMYHTH---FSELLDEFS-QNVLGQLLNDPFLS----------------------------EK SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLCEE PRAQSP--------------------------FTHITTSDSFNDDEVESE--------KWYLSTDFPSTSIKTEPVTDEP P---PGLVPSV-----------------------------------------TLTITAISTPLEKEEPPLEMN---TGV- ---DSSCQTIIPKIKLEPHEVDQFLNFSP------KEAPVDHLH------------------------------------ -------------------------------------------------------------------------------- ------------------------------------LPPTPPSSHGSDSEGSLSPNPR---------------------- -LHPFSLPQTH-SPSRAAPRAPSALSSS---PLLTAPHKLQG-------------------------------------- ------------------------------------------------------SGPLVLTEEEKRTLIAEGYPIPTKLP LSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNRTLLQQLQKLQTLVMG K-VSRTCKLAGTQTGTCLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK-------- ---------MALPSQHSLQEP----------------------------------------YTASVVRSRNLLIYEEHSP PEESSSPGSAGELGG----WDRGS-SLLRVS-GLESRP-----------------DVDLPHFIISNETSLEKSVLLELQQ HLVSAKLEGNETLKVVELDRRVNTTF------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------- >Pan_troglodytes_CREB3L2 --------------------------------------------------------------MEVLESGEQG------VL QWDRKLSELSEPGDGEALMYHTH---FSELLDEFS-QNVLGQLLNDPFLS----------------------------EK SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLCEE PRAQSP--------------------------FTHITTSDSFNDEEVESE--------KWYLSTDFPSTTIKTEPITDEP P---PGLVPSV-----------------------------------------TLTITAISTPLEKEEPPLEMN---TGV- ---DSSCQTIIPKIKLEPHEVDQFLNFSP------KEAPVDHLH------------------------------------ -------------------------------------------------------------------------------- ------------------------------------LPPTPPSSHGSDSEGSLSPNPR---------------------- -LHPFSLPQTH-SPSRAAPRAPSALSSS---PLLTAPHKLQG-------------------------------------- ------------------------------------------------------SGPLVLTEEEKRTLIAEGYPIPTKLP LSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNRTLLQQLQKLQTLVMG K-VSRTCKLAGTQTGTCLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK-------- ---------MALPSQHSLQEP----------------------------------------YTASVVRSRNLLIYEEHSP PEEPSSPGSAGELGG----WDRGS-SLLRVS-GLESRP-----------------DVDLPHFIISNDTSLEKSVLLELQQ HLVSAKLEGNETLKVVELDRRVNTTF------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------- >Canis_familiaris_CREB3L2 --------------------------------------------------------------MEVLESGEQS------VL QWDRKLSELSEPGETEALMYHTH---FSELLDEFS-QNVLGQLLNDPFLS----------------------------EK SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLCEE PRAQSP--------------------------FTHVTTSDSVNDDEVESE--------KWYLSTDFPSTTIKTEPITEEP P---PGLVPSV-----------------------------------------TLTITAISTPCEKEEPPLEMN---PGV- ---DSSCQTIIPKIKLEPHEVDQFLNFSP------REASVEHLH------------------------------------ -------------------------------------------------------------------------------- ------------------------------------LPPTPPSSHSSDSEGSLSPNPR---------------------- -LHPFSLPQTH-SPARAVARAPSALSNS---PLLTAPHKLQG-------------------------------------- ------------------------------------------------------SGPLVLTEEEKRTLIAEGYPIPTKLP LTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNRTLLQQLQKLQTLVMG K-VSRTCKLAGTQTGTCLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK-------- ---------MALPSQHSVQEP----------------------------------------YTASVVRSRNLLIYEEHSP LEEPLSPASAGELGH----WDRGS-SLLRAS-GLETRP-----------------DVDLPHFIISNETSLEKSVLLELQQ HLVSAKLEGNETLKVVELDRRVNATF------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------- >Myotis_lucifugus_CREB3L2 --------------------------------------------------------------LSVRESGWGCSFFM--VR QWNKGCRDLCEYMYG-LFLYHLHGRHFSELLDEFS-QNVLGQLLNDPFLS----------------------------EK SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLSEE PRAQSP--------------------------FTHVTNSDSFNDDEVENE--------KWYLSTEFPSTTIKTEPITEES P---PGLVPSV-----------------------------------------TLTITAISTPFEKEEPPLEMN---TGV- ---DSSCQTVIPKIKLEPHEVDQFLNFSP------KEASVDHLH------------------------------------ -------------------------------------------------------------------------------- ------------------------------------LPPTPPSSHSSDSEGSLSPNPR---------------------- -LHPFGLPQTH-SPARAVPRAPSALSSS---PLLTAPHKLQG-------------------------------------- ------------------------------------------------------SGPLVLTEEEKRTLVAEGYPIPTKLP LTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNRALLQQLQKLQTLVMG K-VSRTCKLAGTQTGTCLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK-------- ---------MALPSQHSMPEP----------------------------------------YTASVVRSRNLLIYEEHSP LEEPSSPASAGELGR----WDRGS-SLLRAS-GLESRP-----------------DVDLPHFIISNESSLEKSVLWELQQ HLAGAKLEGNETLKVVELDRRVNATF------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------- >Pteropus_vampyrus_CREB3L2 --------------------------------------------------------------MEVLESGEQS------VL QWDRKLSELSEPGESEALMYHTH---FSELLDEFS-QNVLGQLLNDPFLS----------------------------EK SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLCEE PRVQSP--------------------------FTHVTSSDSFNDDDVESE--------KWYLCTDFPSATIKTEPITDEP P---PGLVPSV-----------------------------------------TLTITAISTPLEKVEPPLEMS---TGV- ---DSSCQTIIPQIKLEPHEVDQFLNFSP------KEASVDHLH------------------------------------ -------------------------------------------------------------------------------- ------------------------------------LPPTPPSSHSSDSEGSLSPSPR---------------------- -LHPFGPAQTH-SPARAVVRAPSTLSSS---PLLTAPHKLQG-------------------------------------- ------------------------------------------------------SGPLVLTEEEKRTLIAEGYPIPTKLP LTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNXXXXQQLQKLQTLVMG M-VSRTCKLAGTQTG-CLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK-------- ---------MALPSQHSMPEP----------------------------------------YTASIVRSRNLLIYEEHSP LEEPSSPASAGELGR----WDRGS-ALLRAS-GLEPRP-----------------DMDLPHFILANDTSLEKSVLLELQQ HLVGTKLEGNETLKVVELDRRVNATF------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------- >Danio_rerio_CREB3L2_a --------------------------------------------------------------MEIMD-SGEPF------L QWDKNLSELSEAGEND-ILYSTH---FTDLLDDLSQEALLGQLLSDPFLSGRG------------------------DAM DTEE--ELTRASPVPP---------------------------------------------------HIQAEHSYSLCGD SRPQSP--------------------------LSHLPGEPGSDAADSESD--------EWPMEQEDKGIKMEPLLCVPLP A--LTLTVTPA-----------------------------------------GSAPEPVIDSCDSAQSLSLP-------- ---QVKEDSNSPQIKLEPHEVDQFLNLSPK--------GLECLQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------MPPTPPSSVGSDSEGSQSPVH----------------------- -PCAPASPTQTPAVLKVAPRAPSSLSSS---PLLTAPHKLQG-------------------------------------- ------------------------------------------------------SGPLLLTEEEKRTLIAEGYPVPTKLP LSKAEEKALKKIRRKIKNKISAQESRRKKKEYVDALEK-KVETCSNENHELRRKVENLEC--TNKSLLQQLHSLQAVVAG K-VPRSCRVTGTQTSTCLMVV----------------------------VLCFSLFLGSFYPG-LSPCSSITK------- ---------ADLS-REISIHD----------------------------------------SYTTTVKSRSLLSIQEPGG LDEPHPIGLGGEYP--EWDRQADVMAAWRFEQQHKEEEA--------------ELHKAEHRPLLLSTNETHAQKAILIDL HT---HRSNETA-KVIQLDRTVNETS------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------- >Takifugu_rubripes_CREB3L2_b --------------------------------------------------------------MEILD-STEPF------L HWDRNLSELSDTEEIDSMLYTNH---FSELLDDLSQDALLGQLLSDPFLSGGRC---------------------GVEAM EGEDSGDLSPSSPLPP---------------------------------------------------HITAEHSYSLCGD SRPQSP--------------------------LSHLTGEQGSEAGESEGD------SADWPMEQEEAMDSLLCETPSLIP T--LSLSLPQG-----------------------------------------PEGPAAASPAAAAALPAVAS-TSASSN- ---QIKEESVLPQIKLEPHEVDQFLNLSPK--------GLESLQ------------------------------------ -------------------------------------------------------------------------------- ------------------------------------MPPTPPSSHGSDSEGSQSPVHA-PPGLS---------------- RPTSPTSPAPAQAALKTSPRASSCLSNS---PLLTAPHKLQG-------------------------------------- ------------------------------------------------------SGPLILTEEERRTLVAEGYPVPTKLP LTKAEEKALKKIRRKIKNKISAQESRRKKKEYMDTLEK-KVETCTNENSELRRKVENLDK--DNKSLLQQLQSLQDMVAG K-LAKSCRVAGTQTSSCLMVV----------------------------MLCFALFLGSFYPGSFIPSSSITE------- ---------TGLASKQLTIKE----------------------------------------SYIATGFS----------- -------------------------AACGRSD----------------------TLYFLFCTFRAKIEG----------L PRGACTHSGKFQ-KM----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Strongylocentrotus_purpuratus_CREB3L2 ------------------------------------------------------------MTDHLDGLSSPS-------- -------YYEYDYLFDDDPLLSADKMVSGEASDPTLPHIASEHSYS------------------------------MMSE PNSPMMKDIK--------------------------------------------------------------QEDDLDSN YDPEGL--------------------------QDMLPVSPETDDHHISLI---------SSDQHNNTTTTTTAGGLTTGY LLMDKLTGAKS-----------------------------------------ILTTANRTSLTRNGELKPT-------TT TLQQKQDGSKIKLELVTMMNVDNGLGSKH-----------------Q--------------------------------- -------------------------------------------------------------------------------- ------------------------------------MPPTPPGSTASYSDSDGSESPG---------------------- ----RSTPSSPRAVPIQPAKRPICHTRTVSPQLFTNIQKLPQ-------------------------------------- ------------------------------------------------------SGPLHLTEEERRTLRQEGYPIPTKLP LTKAEEKSLKKVRRKIKNKISAQESRRKKKEYLEALEK-RMDSYTSENTELKRKVENLEN--TNQSLSSQLSKLQSIVN- K-ISKPIKAHTTQTGTCLMV----------------------------LVLCFAVFLGSWTPHSFLSSNQ-HL------- ---------PKLFSSSSSPNNDMPHPFFGPYGNNIQYSAPSFHGDDGEDQPDPIFRMYGPKPASGSEDDDPYTTHSMRSS RTLLSYQDEEDAFAGIDPHYHDDSHALLDNIAPEAPSFA--------------KMAAALMTGLGSEVAGVESEETGYEAY MMHPDMEAKIIPVDTMALINRSSNK------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Homo_sapiens_CREB3L3 -------------------------------------------------------------------------------- --------------MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQ--------------------------------D GILRHVELGEG-------------------------------------------------------WGHV-KDQQVLPNP DSDDF---------------------------LSSILGSG-DSLPSS----------PLWSP-EGSDSG-ISEDLPSDPQ DT-------------------------------------------------------------------------PPRSG --PATSPAGCHPAQPGKGPCLSYHPG------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------NSCSTTTPGPVIQVPEASVTIDL----------EMWSPGGRICAEK PADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLLRPG--------------------------------------- ---------------------------------------------------AGHCQELVLTEDEKKLLAKEGITLPTQLP LTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ STSK------SAQTGTCVAVLL----------------------------LSFALIILPSISPFGPN------------- --------KTESPGDFAPVRVFS--------------------------------------RTLHNDAASRVAADAVPGS EAPGPRPEADTTREE----SPGSPGADWG-FQDTANL---------------TNSTEELDN---ATLVLRNATEGLG-QV ALLDWVA--PGPSTGSGRAGLEAAGDEL---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Pan_troglodytes_CREB3L3 -------------------------------------------------------------------------------- --------------MNMDLAAGKMASAACSMDPIDSFELLDLLFDRQ--------------------------------D GILRHVELGEG-------------------------------------------------------WGHV-KDQQVLPNP DSDDF---------------------------LSSILGSG-DSLPSS----------PLWSP-EGSDSG-ISEDLPSDPQ DT-------------------------------------------------------------------------PPRSG --PATSPAGCHPAQPGKGPCLSYHPG------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------NSCPTTPPGPVIQVPEASVTIDL----------EMWSPGGRICAEK PADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLLRPG--------------------------------------- ---------------------------------------------------AGHCQELVLTEDEKKLLAKEGITLPTQLP LTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ STSK------SAQTGTCVAVLL----------------------------LSFALIILPSISPFGPN------------- --------KTESPGDFAPVRVFS--------------------------------------RTLHNDAASRVAADAVPGS EAPGPRPEADTTQEE----SPGSPGADWG-FQDTANL---------------TNSMEELDN---ATLVLRNATEGLG-QV PLLDWVA--PGPSTGSGRAGLEAAGDEL---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Gorilla_gorilla_CREB3L3 -------------------------------------------------------------------------------- --------------MNTDLAAGKMASAACSMDPIDSFELLDLLFDRH--------------------------------D GILRHVELGEG-------------------------------------------------------WGHV-KDQQVLPNP DSDDF---------------------------LSSILGSG-DSLPSS----------PLWSP-EGSDSG-ISEDLPSDPQ DT-------------------------------------------------------------------------PPRSG --PATSPAGCHPAQPGKGPCLSYHPG------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------NSCSTTPPGPVTQVPEASVTIDL----------EMWSPGGKICAEK PADSVDLSPRCNLTVKDLLLSASSGDLQQHHLGTSYLLRPG--------------------------------------- ---------------------------------------------------AGHCQELVLTEDEKKLLAKEGITLPTQLP LTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ STSK------SAQTGTCVAVLL----------------------------LSFALIILPSISPFGPN------------- --------KTESPGDFAPVRVFS--------------------------------------RTLHNDAASRVAADAVPGS EAPGPRPEADTTREE----SPGSPGADWG-FQNTANL---------------TNSTEELDN---ATLVLRNATEGLG-QV ALLDWVA--PGPSTGSGRAGLEAAGDEL---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Macaca_mulatta_CREB3L3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------QQHHLGVSHLLRPG--------------------------------------- ---------------------------------------------------AEHCQELVLTEDEKKLLAKEGITLPTQLP LTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ STSK------SAQTGTCVAVLL----------------------------LSFALIILPSISPFGPN------------- --------KAESPGDFAPVRVFS--------------------------------------RTLHNDAASRVTSDAVPGS EAPGPQPEADTTQEG----SPGIPGADWD-FRDSANL---------------TNSTEEVDN---ATLILRNATEGLG-QV TLLDWVA--PGPSTGSGRAGLEAAGDEL---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Canis_familiaris_CREB3L3 -------------------------------------------------------------------------------- --------------VNGDLAAGKMASSVGPLDPIGSLELLDLLFDQQ--------------------------------D GILRHVELGED-------------------------------------------------------WDHV-GDQQVLPGP DSDDF---------------------------LNSILAPG-DSVPSS----------PIWSP-AASDSG-ISEDLPSDPQ DT-------------------------------------------------------------------------PPRSA --AAATPAGCHALESGKGLCASYHPG------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------PPCLAGGPGPATQALEASVAIDL----------EMWSSG--LGSEE LGELAGPPPCCSLTVKDLLLSGSGADLQQHHLAAPHLLRPG--------------------------------------- ---------------------------------------------------PEQCQELVLTEDEKKLLAKEGITLPTQLP PSNYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ STSK------SAQTGTCLAVLL----------------------------FSFALIVLPSISPFVAN------------- --------KAKHAGDYAPVRVFS--------------------------------------RTLHNDPASRVAPDAIPGS EAPGPRPKGGTPQEG----SPGSPVADWE-SR-TSAL---------------DNWTKGLDNN--ATLILGNDSEKLNPPA TLLGWTA--PEPTLSSGRVGLEAAGEEL---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Felis_catus_CREB3L3 -------------------------------------------------------------------------------- --------------MNGDLAAGKMASSTGPMGPIGSLELLDLLFDHQ--------------------------------D GILRHVELGED-------------------------------------------------------WGHL-EDQQSTSFP DSDDF---------------------------LNSILASG-DSVPSS----------PIWSP-AASDSG-ISEDLPSDSQ DT-------------------------------------------------------------------------PPRSG --AATTPAG----------CPPYHPG------------------------------------------------------ -------------------------------------------------------------------------------- ----------------------------------APCLAGPPGPVAQVLDASVAIDL----------EMWSQG--LRREE RAELADLPLSCSLTVKDLLLSGGGGDLQQHHPGAPHLPRPA--------------------------------------- ---------------------------------------------------TQHCQELVLTEDEKKLLAKEGLTLPTQLP LTKYEERALKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ STGK------SAQTGTCIAVLL----------------------------FSFALIVLPSISPFVAN------------- --------KAESAGDYAPVRVFS--------------------------------------RTLHNDAASRVAPDATPGS EVPGPRPKAGASQEG----SPGSPRADWE-SQGKSAL---------------DNLTEELDN---STLIADNSTEKLN-RA TLLDWTA--PEPALSPGRGGLEAAGEEL---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Gasterosteus_aculeatus_CREB3L3_a -------------------------------------------------------------------------------- ------------------------MEPYQ-DEGCDGIELLDWLFDQN--------------------------------E GILRHEETGRHGNH--------------------------------------------------HAWPVQDPSMPP---- ADDDF---------------------------LNALLRGSSGSASGS----------PLWAS-SPSDSG-ISEDPPSDQM DS-------------------------------------------------------------------------PRRPE SPNGDARCFGARPRTKAGLEATASADL----------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------DGWQAAFPAGRTG---ITQCPLD----------------------- -AHRAQMPSGFALTVKDLLLSGTQEP--------PPHPPHQ--------------------------------------- ---------------------------------------------------S--IQELILNEDEKKLLAKEGVSLPGQLP LTKYEERILKKIRRKIRNKQSAQESRKKKKEYIDGLES-RMAACNAHNHELQRKVSQLQK--CNMSLKEQLRRLQAMVMS SSHK------PAQAGTCVLVLL----------------------------LSFSLILFPSLKPFSDA------------- --------KVSQ-GDFSPVRIQS--------------------------------------RSLQNLQASRVLHVTE--F PAEDEVEPLHRHVPGRR------DVEDITAVMEKLGV---------------SPERPDAEPVAVNSSRQERVVDDFHVDP ITGHIAS---LTLDPRRSARLRPHADDM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Homo_sapiens_CREB3L4 -------------------------------------------------------------------------------- ------------------------MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHC-------------------PPPEV PVTRLQEQGLQGWK--------------------------------------------------SGGDRG----CGLQES EPED----------------------------FLKLFIDPNEVYCS--------------EASPGSDSG-ISEDPCHPDS PP-------------------------------------------------------------------------APRAT ---SSPMLYEVVYEAGALERMQGETGPNV--------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------GLISIQLDQWSPAFMVPD------------------------ -----------SCMVSELPFDAHAHILPRAGTVAPVPCTTL--------------------------------------- ---------------------------------------------------LPCQT-LFLTDEEKRLLGQEGVSLPSHLP LTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSAQNQELQKKVQELER--HNISLVAQLRQLQTLIAQ TSNK------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQSR------------- --------PEAGSED-YQPHG----------------------------------------VTSRNILTH---------- ----------------------------KDVTENL-------------------------ETQVVESRLREPPGAKDANG STRTLLEKMGGKPRPSGRIRSVLHADEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Pan_troglodytes_CREB3L4 -------------------------------------------------------------------------------- ------------------------MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHC-------------------PPPEV PVTRLQEQGLQGWK--------------------------------------------------SGGDRG----CGLQES EPED----------------------------FLKLFIDPNEVYCS--------------EASPGSDSG-ISEDPCHPDS PP-------------------------------------------------------------------------APRAT ---SSPTLYEVVYEAGALERMQGETGPNV--------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------GLISIQLDQWSPAFMVPD------------------------ -----------SCMVSELPFDAHAHILPRAGTVAPVPCTTL--------------------------------------- ---------------------------------------------------LPCQT-LFLTDEEKRLLGQEGVSLPSHLP LTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSAQNQELQKKVQELER--HNISLVAQLRQLQTLIAQ TSNK------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQSR------------- --------PEAGSED-YQPHG----------------------------------------VTSRNILTH---------- ----------------------------KDVTENL-------------------------ETQVVESRLREPPGAKDANG STRTLLEKMGGKPRPSGRIRTMLHADEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Macaca_mulatta_CREB3L4 -------------------------------------------------------------------------------- ------------------------MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHC-------------------PPPEV PVTRLQEQGLQGWK--------------------------------------------------SGGDHG----CGLQES EPED----------------------------FLKLFIDPNEVYRS--------------EASPGNDSG-TSEDPCRPDS PP-------------------------------------------------------------------------APRAT ---SSPTLYEVVYEAGALERMQGETGPTV--------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------GLISIQLDQWSPAFMVPD------------------------ -----------SCMVSELPFDAHAHILPRAGTLAPVPCTTL--------------------------------------- ---------------------------------------------------LPCQT-LFLTDEEKRLLGQEGVSLPSHLP LTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSAQNQELQKKVQELER--HNISLVAQLRQLQTLIAQ TSNK------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQGR------------- --------PEAGPED-YQPHG----------------------------------------VTSRNILTH---------- ----------------------------KDITENL-------------------------ETQVVESRLREPPEAKDAND STRTLLEKMGGKPRPSGRIGTVLHADEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Mus_musculus_CREB3L4 -------------------------------------------------------------------------------- ------------------------MELGCPELL----EPPEDIFSTGSFLELGFNG-------------------PASKV PVTR-----------------------------------------------------------------------GLQKS EPDD----------------------------FLNLFIDPNMIHCS--------------ETSPGRDSG-VSEDPG---- SP-------------------------------------------------------------------------AQQAS ---SSPALYEVVYDSGTLQGTQREAGPTF--------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------GLISIQIDQWTPALMVPD------------------------ -----------ACTVSGLPSDSHRHILPRVSTRAPAPPAAM--------------------------------------- ---------------------------------------------------PSCQHHLFLTDEEKQLLAQEGITLPSHLP LTKAEERILKKIRRKIRNKQSAQDSRRRKKEYLDGLES-RVAACSEQNQKLQRKVQELER--QNIFLMEQVRQLQKLTAQ TSSR------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQGQ------------- --------SEARPED-YQLHG----------------------------------------VISRNILTH---------- ----------------------------ENVTENL-------------------------ESPVLKSKLEELPEAPTTNG STKT-HLKMRVKARPPGQIRGMVHTDEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Rattus_norvegicus_CREB3L4 -------------------------------------------------------------------------------- ------------------------MELGCPELL----EPPEDIFSTGSFLELGFNG-------------------PPSK- ---------------------------------------------------------------------------GLQKS ESDD----------------------------FLNLFIDPNMIRCS--------------ETSPGSDSG-VSEDPG---- SP-------------------------------------------------------------------------APQAP ---SSPALYEVVYEAGALQGTQREAGPTF--------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------GLISIQIDQWSPAFMVPG------------------------ -----------ACTVSDLPSEAHRHILPRVSTIAPPPPAAL--------------------------------------- ---------------------------------------------------LSCQR-LFLTDEEKHLLGQEGVTLPSHLP LTKAEERILKKIRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSEQNQKLQRKVQELER--QNISLVAQVHQLQKFTAQ TSSR------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQSQ------------- --------PEARSEG-YQLHG----------------------------------------VISRNILTH---------- ----------------------------EDMTESP-------------------------ESPVLKANLEELPQVPATNG STKMAHLKMRVKARPTGPIRGMVHADEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Canis_familiaris_CREB3L4 -------------------------------------------------------------------------------- ------------------------MDFRAPGLLDQWLEPPEEVFSAGAFLELGPPC-------------------PHAEA PGTP--EQGLPGNW--------------------------------------------------AVQGRGESGSGGLQES EPED----------------------------FLKLFIDPNEVYCS--------------QASPGSDSG-ISEDPGHPDG PR-------------------------------------------------------------------------APKAP ---SSPAVCEVVFEAGVLQRMEGPPG------------------------------------------------------ -------------------------------------------------------------------------------- --------------------------------------RLISVHLDQWNPPLPVPE------------------------ -----------ACMVCELPLDAHTHTLPRAGSVNPVPPATL--------------------------------------- ---------------------------------------------------LPCQT-VFLTEEEKRLLGQEGVSLPTHLP LTKAEERVLKKIRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSAQNQELQKKVQELER--HNISLVTQLRQLQTLIAQ TSNK------AAQTSTCVLILL----------------------------FSLALIVLPSVSPLQGL------------- --------REAGSED-YQPHG----------------------------------------VISRNILTH---------- ----------------------------KDMIENL-------------------------ETTVVESRLEGPPRTKDVNG STRTLLEKMGGKTGPGGHIRTVLHADEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Felis_catus_CREB3L4 -------------------------------------------------------------------------------- ------------------------MDFRTPDLLDAWLESPEDVFSTGTFPEPGLHG-------------------PPPEA PGTKLQEQGLRGWE--------------------------------------------------PSGGRG----CGLRDS EPED----------------------------FLKLFIDPNEVYCS--------------GASASSDSGHPSADPGRPDR PP-------------------------------------------------------------------------APQAP ---SPPALYEVVYEAGALERTQGEAGPAV--------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------GFISLQPGQRSPQLTVPD------------------------ -----------ACVVCELPCDAH-DTLPGAGTVNPVPPATL--------------------------------------- ---------------------------------------------------LPCQT-LFLTEEEKRLLGQEGVSLPAHLP LTKAEERVLKKVRRKIRNKQSAQDSRQRKKEYIDGLES-RAAACSAQNQELQKKVQELER--CNVSLVAQLRQLQLLAAR TSDK------AAQTSTCVVILL----------------------------FSLALIILPSVSPFQGL------------- --------REAGPED-YQPHGAT--------------------------------------VVSRNILSH---------- ----------------------------KDMTEGL-------------------------ETTVVESRPGGPLKAKGENG STRTLLEKMGGKTGSNGHAGAVLHAEEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Myotis_lucifugus_CREB3L4 -------------------------------------------------------------------------------- ------------------------MDFGTPDLLDVWLEPPDDVL-TGPFLELGLHC-------------------PPPEV PVTMLQEQGLQGWE--------------------------------------------------SSGAPA----CGLQES EPED----------------------------FPKLFIDPNEVYCS--------------EASPGSDSG-ISEHPGRRDS PP-------------------------------------------------------------------------VPQAP ---SSPALYEVVYETEALEKMQEEAGPAV--------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------GFISIQLDQWSPPFMMPD------------------------ -----------ACMVSNVPLDAHAHILPRAGTVNPVLPATL--------------------------------------- ---------------------------------------------------LPCQA-LFLTDEEKHLLGQEGISLPSHLP LTKTEERVLKKVRRKIRNKQSAQDSRRRKKEYIEGLES-KVAACSAQNQQLQKKIQELER--HNVSLVTQLRQLQMLITQ TSNK------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQGP------------- --------PEAGSED-YQPHG----------------------------------------VISRNILIH---------- ----------------------------KDVTKNW-------------------------ETPEVESRLGGPPGIKSANG STTTLLEKTGGKTGPRGLLRTVLHADEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Pteropus_vampyrus_CREB3L4 -------------------------------------------------------------------------------- -------------------------DFGTPDLLDVWLEPPEDVFSTGSFLELGLHC-------------------PPPEA PVTRMQEQGLQGWE--------------------------------------------------STGGRG----RGLQES EPED----------------------------LPKLCIDPNEVYCS--------------EASPGSDSG-LSEDPGRPDS PP-------------------------------------------------------------------------APKAP ---SSPALYEVIYEAGALERMQGEARPAV--------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------GLISIQLDQWSPPFMVPE------------------------ -----------ACVVSELPLDARVHLLPPAGAVSPVPPSTL--------------------------------------- ---------------------------------------------------LSCQA-LFLTDEEKRLLGQEGVSLPSHLP LTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSVQNQELQKKVQELER--HNISLVTQLRQLQMLMTQ TSNK------AAQTSTCVLILL----------------------------FSLALIILPSLSPFQGL------------- --------PEARPKD-YQPHG----------------------------------------VISRNILTH---------- ----------------------------KDMMENQ-------------------------ETPVAESRLGGPPGAKGANG STRTLLEKMGGKTGPGGHVRTTVHADEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Takifugu_rubripes_CREB3L4_a -------------------------------------------------------------------------------- ------------------------MNADSRELSLGSSEDETQTLFSCSDLIFSSEE-------------------KSLLD WAVEP----------------------------------------------------------------------DCALN DSETE---------------------------DFLHAVDPNEVFPRG----------PPMALSSESDCS-LSEDPPVVSP VT-------------------------------------------------------------------------MVTTP --VEPATVYQVVYDLSGLGTVKPEPGQENV-------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------VSIELADDW-ASKVLISD------------------------ -----------SCIVGELPVFSTAHVNPPS---PDGNLVRL--------------------------------------- ---------------------------------------------------LSFYAELQLTEEEQKLLSQEGVSLPTNLP LTKAEERVLKRIRRKIRNKQSAQDSRRRRKEYIDTLES-RAAACSAQNKELQRTVEHLEK--RNMSLLMQLRQLQSLIKQ TVSK------GAQTSTCLLIIL----------------------------LSLALIIMPSFSPFR-R------------- --------SWSSDD--FRPIG----------------------------------------VLSRNILTDSASWRTVVDD VD--------------RR----ADSEVRQTGPADVSE---------------PTQVPENRTQDGGQSAPASPPRQTEPPA LDSAAAAGAKR----SHNATKAGRADEM---------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------- >Oryzias_latipes_CREB3L4_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------MLS DS-----------------------------------------------------------------CP-L---IPVAGP G-----------------------