>Homo_sapiens_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MDG--------------IVPDIAVG---------------- ---TKRGSDELFSTCVTNGPFIMSSNSA----------SAANGNDSKKFKGDSR--------------------SAGVPS RVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKT DSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMA--------------------------GQSPVLRIIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDYTRPDLPSGDSQPSLDQTMAAA--FGAPGIISASPYAG--AGFPPTFAIPQAAGLSVPN--VHGALAP---LAIP S--AAAAAAAAG------RIAIPGLA-GAG-NSVLLVSNLNPE---RVTPQSLFILFG-------VYGDVQRVKILFNKK ENALVQMADGNQAQ-LA--MSHLNGHKLHGKPIRITLSKHQNVQLPR--EGQEDQGLTKDYGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVS-EEDLKVLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIDLHNHDLGENHHLRVS FSKSTI- >Pan_troglodytes_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MDG--------------IVPDIAVG---------------- ---TKRGSDELFSTCVTNGPFIMSSNSA----------SAANGNDSKKFKGDSR--------------------SAGVPS RVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKT DSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMA--------------------------GQSPVLRIIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDYTRPDLPSGDSQPSLDQTMAAA--FGAPGIISASPYAG--AGFPPTFAIPQAAGLSVPN--VHGALAP---LAIP S--AAAAAAAAG------RIAIPGLA-GAG-NSVLLVSNLNPE---RVTPQSLFILFG-------VYGDVQRVKILFNKK ENALVQMADGNQAQ-LA--MSHLNGHKLHGKPIRITLSKHQNVQLPR--EGQEDQGLTKDYGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVS-EEDLKVLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIDLHNHDLGENHHLRVS FSKSTI- >Callithrix_jacchus_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MDG--------------IVPDIAVG---------------- ---TKRGSDELFSTCVTNGPFIMSSNSA----------SAANGNDSKKFKGDSR--------------------SAGVPS RVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEETANTMVNYYTSVTPVLRGQPIYIQFSNHKELKT DSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMVMA--------------------------GQSPVLRIIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDYTRPDLPSGDSQPSLDQTMAAA--FGAPGIISASPYAG--AGFPPTFAIPQAAGLSVPN--VHGALAP---LAIP S--AAAAAAAAG------RIAIPGLA-GAG-NSVLLVSNLNPE---RVTPQSLFILFG-------VYGDVQRVKILFNKK ENALVQMADGNQAQ-LA--MSHLNGHKLHGKPIRITLSKHQNVQLPR--EGQEDQGLTKDYGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVS-EEDLKVLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIDLHNHDLGESHHLRVS FSKSTI- >Mus_musculus_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MDG--------------IVPDIAVG---------------- ---TKRGSDELFSTCVSNGPFIMSS-SA----------SAANGNDSKKFKGDNR--------------------SAGVPS RVIHVRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELKT DSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMA--------------------------GQSPVLRIIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDYTRPDLPSGDSQPSLDQTMAAA--FGAPGIMSASPYAG--AGFPPTFAIPQAAGLSVPN--VHGALAP---LAIP S--AAAAAAAS-------RIAIPGLA-GAG-NSVLLVSNLNPE---RVTPQSLFILFG-------VYGDVQRVKILFNKK ENALVQMADGSQAQ-LA--MSHLNGHKLHGKSVRITLSKHQSVQLPR--EGQEDQGLTKDYGSSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVS-EDDLKSLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIELHNHDLGENHHLRVS FSKSTI- >Felis_catus_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MDG--------------IVPDIAVG---------------- ---TKRGSDELFSACVTNGPFIMSSNSA----------SAANGNDSKKFKGDNR--------------------SAGVPS RVIHIRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKT DSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMA--------------------------GQSPVLRIIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDYTRPDLPSGDSQPSLDQTMAAA--FGAPGIMSASPYAG--AGFPPTFAIPQAAGLSVPN--VHGALAP---LAIP S--AAAAAAAAG------RIAIPGLA-GAG-NSVLLVSNLNPE---RVTPQSLFILFG-------VYGDVQRVKILFNKK ENALVQMADGSQAQ-LA--MSHLNGHKLHGKPVRITLSKHQNVQLPR--EGQEDQGLTKDYGNSPLHRFKKPG-KNFQNI FPPS---ATLHLSNIP------------------------YVQG-----------VGCGLPAPPDLHNHDLGENHHLRVS FSKSTI- >Myotis_lucifugus_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------G--------------QTQCRAVS---------------- ---SQRGSDELFSACVTNGPFIMSSNSA----------SAANGNDSKKFKGDNR--------------------STGVPS RVIHIRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKT DSSPNQARAQAALQAVNSVQSGNLSLAASAAAVDAGMAMA--------------------------GQSPVLRIIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALLQYAEPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDYTRPDLPSGDSQPSLDQTMAAA--FG----------------------------LSVPN--VHGALAP---LAIP S--AAAAAAAAG------RIAIPGLG-GAG-NSVLLVSNLNPE---RVTPQSLFILFG-------VYGDVQRVKILFNKK ENALVQMADGSQAQ-LA--MSHLNGHKLHGKPVRITLSKHQNVQLPR--EGQEDQGLTKDYGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVS-EDDLKILFSSNGGIVKGFKFFQKDRKMALIQMGSVEEAIQALIDLHNHDLGENHHLRVS FSKSTI- >Monodelphis_domestica_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MDG--------------IVPDITVG---------------- ---TKRGSDELFSTCVTNGPFIMSSNSA----------SAANGNDSKKFKGDNR--------------------SPGVPS RVIHVRKLPGDVTEAEVISLGLPFGKVTNLLMLKGKNQAFLEMNTEEASNTMVSYYTTVTPVLRSQPIYIQFSNHKELKT DNSPNQARAQAALQAVNSVQSGNLALSASAAAADAGMAVA--------------------------GQSPVLRIIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALLQYSDPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDYTRPDLPSGDSQPSLDQTMAAA--FGAPGIISASPYAG--AGFPPTFAIPQAAGLSVPN--VHGALAP---LAIP S--AAAAAAAAG------RIAIPGLT-GAG-NSVLLVSNLNPE---RVTPQCLFILFG-------VYGDVQRVKILFNKK ENALVQMADGNQAQ-LA--MSHLNGQKLHGKPIRITLSKHQTVQLPR--EGQEDQGLTKDYGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSIS-EEDLKMLFSSNGGMVKGFKFFQKDRKMALIQMGSVEEAIQSLIDLHNHDLGENHHLRVS FSKSTI- >Gallus_gallus_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------ISD-------------------QLPMLKLS---------------- ---LKRGSDELFSTCVTNGPFIMSSNAS----------SAANGNDSKKFKGDSR--------------------SAGVPS RVIHVRKLPSDVTEAEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTTVTPVLRSQPIYIQFSNHKELKT DNSPNQARAQAALQAVNSVQSGNLALPAPAAAVDAGMAMA--------------------------GQSPVLRIIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPMSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDYTRPDLPSGDNQPPLDQTMAAA--FGAPGIIPASPYAG--AGFPPTFAIPQAAGLTVQN--VHGALAP---LAIP ---AAAAAAAAG------RIAIPGLA-GAG-NSVLLVSNLNPE---RVTPQCLFILFG-------VYGDVQRVKILFNKK ENALVQMADGNQAQ-LA--MSHLNGQKLHGKPIRITLSKHQTVQLPR--EGQEDQGLTKDYGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSIA-EEDLKMLFSSNGGMVKGFKFFQKDRKMALIQMGSVEEAIQSLIDLHNHDLGENHHLRVS FSKSTI- >Xenopus_tropicalis_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------LFS--------------IVQDITVG---------------- ---TKRGSDELFS-CVTNGPFIMSNATAGENL------YGSNGNDSKKFKGDSR--------------------SVAVGS RVIHVRKLPGDVTEAEVISLGLPFGKVTNLLMLKGKNQVCMKVYSKKNTFCAFNVCCNINSLLVIERMYWLVYGHARLIL NKAAKKMKAQAALQAVNSVVSGTTALSASAAAVDAGMAMS--------------------------GQSPVLRIIVEN-- LFYPVTLDVLQ-QIFSKFGTVLKIITFTKNNQFQALLQYGDPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDYTRPDLPSGDGQPSLDQTIAA---FGAPGLISANPYAS--AGFPPAFAIPQG---------VHGTLAP---LALP SAAAAAAAAAAG------RLGIPGLG-IPG-NSVLLVSNLNPE---RVTPQCLFILFG-------VYGDVHRVKILFNKK ENALVQMADGNQAQ-LA--MSHLNGQRLHGKPLRITVSKHQTVQLPR--EGQEDQGLTKDYSTSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVS-EEDLKMLFSNNGYTVKGFKFFQKDRKMALIQMGSVEEAIESLIELHNHDMGENHHLRVS FSKSTI- >Danio_rerio_PTBP1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MDGRLET-DLYPLG---SSYVTEIDSVH-DITVG---------------- ---TKRGSDELFSSCISNGPYIMSSG-------------AANGNDSKKFKGDIR--------------------SPGIPS RVIHVRKLPNDINEAEVISLGLPFGKVTNLLMLKGKNQAFLEMNTEESAQTMVSYYSSVTPVIRNHPIFMQYSNHKELKT DNSPNQVRAQAALQAVNAVQTGGMSLAAIDG-----AGMG--------------------------SQSPVLRVIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALVQYSDGMTAQHAKLSLDGQNIYNACCTLRISFSKLTSLNVKYNN DKSRDYTRPDLPTGDSQPSFDAQTMAAAALTAPGIISASPYAG-AHGFPQAFAIQQAAGLSLQG--MPAGALASLSVP-G AAAAAAAAAAAG------RLGLSGLT-AAG-NSVLLVSNLNPE---SVTPQCLFILFG-------VYGDVMRVKILFNKK ENALVQMSDGTQAQ-LA--MSHLNGQKLYGKALRATLSKHTTVQLPR--EGHEDQGLTKDYSNSPLHRFKKPGSKNYSNI FPPS---STLHLSNIPPSVT-EDDLRGLFLSSGAVVKAFKFFQKDRKMALIQLASVEEAIESLIKFHNHDLGENHHLRVS FSKSTI- >Danio_rerio_PTBP1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MDGRLET-ELYPMG---SSYA-ELDVVH-DIAVG---------------- ---TKRGSDELFS-CVTSGPYIMSS--------------AANGNDSKKFKGDIR--------------------SPAVPS RVIHVRKLPNDINEAEVIALGLPFGKVTNLLMLKGKNQAFLEMNSEEAAQTMVTYYSSVTPVIRNHPIFMQYSNHKELKT DNSPNQVRAQAALQAVNAVQTGSLTLGGVDP-----SGMT--------------------------GPSPVLRVIVEN-- LFYPVTLDVLH-QIFSKFGTVLKVITFTKNNQFQALLQFTDGLTAQHAKLALDGQNIYNGCCTLRISFSKLTSLNVKYNN DKSRDYTRPDLPTGDSQPALEHH-AVAAAFAAPGIISAAPYAS-AHAFPPAFAIQQAG-LTIPG--VPG-ALASLTIP-G AAAAAAAAS---------RLGFPTLT-GT--HCVMLVSNLNPE---RVTPHCLFILFG-------VYGDVLRVKIMFNKK ENALIQMSDGTQAQ-LA--MSHLNGQKLYGRPLRITLSKHTTVQMPR--EGHEDQGLTKDYSNSPLHRFKKPGSKNYSNI FPPS---STLHLSNIPPSVV-EDDLKLLFGSSGALVKNFKFFQKDRKMALIQMSSVEEAIESLIQFHNHDLGENHHLRVS FSKSTI- >Takifugu_rubripes_PTBP1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------CLCHSRLDT-DLYPLG---SGYVAEIDGVH-DISVG---------------- ---TKRGSDELFSSCISNGPYIMNS---------------ANGNDTKKFKGDVR--------------------SSGVPS RVVHVRKLPNDINEAEVIGLGLPFGKVTNLLMLKGKNQAFLELNSEECAQTMVNYYSSVTPYIRNHPIYMQYSTHKELKT DNSPNQVRAQAALQAVNALHGGGMGGMAIPTDPASIAGAA--------------------------AQSPVLRVIVEN-- LFYPVTLEVLH-QIFSKFGTVLKIITFTKNNQFQALIQHVDSMTAQHAKLSLDGQNIYNACCTLRISFSKLTSLNVKYNN DKSRDYTRPDLPTADSQPSLDPQTMAA-AFAAPGIISASPYGG-AHAFPPAFAIQQTAGLSMPG--IPT-ALASLGVSHG GMAAAAAAAT--------RLGFTGLT-PTAGHNVLLVSNLNPQ---SVTPHCLFILFG-------VYGDVMRVKILFNKK ENALVQMSDGTQAQ-LA--MSHLNGQRLHGREMRVTFSKHTTVQLPR--EGHEDQGLTKDYSNSPLHRFKKPGSKNYSNI FPPS---ATLHLSNIPPAVV-EDDLKRLFASSGATVKAFKFFQKDHKMALIQMGSVEEAIDCLIKFHNHDLGENHHLRVS FSKSTI- >Takifugu_rubripes_PTBP1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------YSSVHQDFTVG---------------- ---TKRGSEELVS-NISNGLYIMSNTVP-----------AANGSDSKKFKGDS-------------------------PS KVVHIRKLPDDITETEVISLGLPFGNVSNLLMLKTKNQAFLEMNCEDAACNMVGYYSTVMPVIRHQPVYVQFSNHKELKT DNSPNQERAQAALRAFGASHMAPC--------------AV--------------------------ASSSVLRVVVEN-- LLYPVSLDALC-QIFSKFGTVLRIIVFTKNSQFQALLQYPDAACAQAAKLSLDGQNIYNACCTLRISFSKLTSLNVKYNN EKSRDFTRPDLPPGDGQPTLEHPSMAA-AFAAPGIISAAPYAGAAQTFSPSYTIQPAVFLPPAG--VTVPALP------- GALTSLSLAGAA------RMGFPSLP-AG--VCVLLVSNLHPE---RVTPHCLFILFEG------VYGDVMRVKILFNKK ETALVQMSDSTQAQ-LA--MSHLNGQKLYGRAVRITVSKHMSVQLPR--EGHEDQGLTKDFSNSPLHRFKKPGSKNYSNI FPPS---ATLHLSNIPPCVV-EDDLKMLFSSSGAEVKAFKFFQKDHKMALIQMGSVEEAIEALIEFHNHDLGENHHLRVS FSKSSI- >Gasterosteus_aculeatus_PTBP1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------HHSRLDA-ELYPLG---TGYVPEIDSVH-DISVG---------------- ---TKRGSDELFSSCISNGPYIMNSV-------------AANGNDSKKFKGDVR--------------------SPGVPS RVVHVRKLPNDINEAEVIGLGLPFGKVTNLLMLKGKNQAFLEMTSEECAQTMVSYYSSVTPVIRNHPIYMQYSTHKELKT DNSPNQVRAQAALQAVSALHGGGMGSMAIPADVSSMGGAG--------------------------SQSPVLRVIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALIQYADGLTAQHAKLSLDGQNIYNACCTLRISFSKLTSLNVKYNN DKSRDYTRPDLPTADSQTSLDHQTMAAAAFAAPGLISASPYGG-AHAFPPAFAIQQASGLSMPG--MPG-ALASLGVGHG GMAAAAAAAS--------RLGLSGFA-APGGHHVLLVSNLNPE---SVTPHCLFILFG-------VYGDVMRVKILFNKK ENALIQMSDSTQAQ-LA--MSHLNGQRLHGRAMRVTSSKHTTVQLPR--EGHEDQGLTKDYSNSPLHRFKKPGSKNYSNI FPPS---ATLHLSNIPPSVV-EEDLKRLFASSGATVKAFKFFQKDRKMALIQMGSVEEAIESLIEFHNHDLGENHHLRVS FSKSTI- >Gasterosteus_aculeatus_PTBP1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------SLEAELIF--LPAAS---NTLSSLHSSVHQDLTVG---------------- ---TKRGSEETFP-SVSIGPYIMSTT--------------ANGNDSKKFKGDIR--------------------GPGVPS RVIHIRKLPNDISEAEVISLGLPFGDITNLLMLKAKNQAFLEMNSEEAAQNMVGYYSTVMPIIRNHLVYVQFSNHKELKT DNSPNQERAQAALRALTSSHVDPT--------------MV--------------------------APSAVLRVVVEN-- LVYPVTLDALC-QIFSKFGTVLRIIVFTKNSQFQALLQYAEGASAQSAKLSLDAQNIYNGCCTLRISFSKLTTLNVKYNN EKSRDFTRPDLPSGDSQPSMEHPAMAT-AFTAPGIISAGPYGGAAHGFQPAFTLQPAMSSHYP---GLVPAMP------- GALASLSLPGAA------RLGFHHMS-AG--VSVLLVSNLNPE---RVTPHCLFILFG-------VYGDVMRVKILFNKK ENALVQMSDCTQAQ-LA--MSHLSGQQLHGKSLRITPSKHTSVQLPR--EGHEDQGLTKDYSNSPLHRFKKPGSQNYSNI FPPS---ATLHLSNIPPVWCGRTTLRCCSPPPGAMVKAFKFFQKDHKMALIQMGSVEEALEALIEFHNHDLGENHHLRVS FSKSSI- >Oryzias_latipes_PTBP1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------CAMDGRLDATELYPLG---SGYVPEIESVH-DISVG---------------- ---TKRGSDELFSSCITNGPYIMNS--------------AANGNDSKKFKGDVR--------------------SPGVPS RVVHVRKLPNDINEAEVISLGLPFGKVTNLLMLKGKNQAFLEFGSEECAQTMVSYYSSVTPVIRNHPIYMQYSTHKELKT DNSPNQVRAQAALQAVNALHGSGMGSMAISAEAASMGGAA--------------------------SQSPVLRVIVEN-- LFYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALIQYADAMTAQHAKLSLDGQNIYNACCTLRISFSKLTSLNVKYNN DKSRDYTRPDLPTADSQPSLDHQAMAAAAFG-PGIISASPYGG-AHAFPPTFTFQQAG-LSMQG--IPS-ALASLGVGHS GMAAAAAAAAAT------RLGLSGLG-ATGGHNVLLVSNLNPESLKSVTPHCLFILFG-------VYGDVMRVKILFNKK ENALVQMSDGTQAQ-LS--MSHLNGQRLHGRAIRVTLSKHTTVQLPR--EGHEDQGLTKDYSNSPLHRFKKPGSKNYSNI FPPS---ATLHLSNIPPSVM-EDDLRRLFASTGATVKAFKFFQKDRKMALIQMGSVEEAIECLIEFHNHDLGENHHLRVS FSKSTI- >Oryzias_latipes_PTBP1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------LRAPL---TSLLSFP-------------------------- ----QRGSDELLS-SVSNGPYIMNTTVGTKN-------FEANGNDSKKFKGDLR--------------------GPNVPS RVLHIRKLPIDITETEVISLGLPFGDVTNLLMLKAKNQAFLEMNSEEAAQNMVGYYSTVMPIIRQQPVFVQFSNHKELKT DNSPNQERAQAALRALSSSHVDTAA------------LVV--------------------------APSSVLRVVVEN-- LLYPVSLDALC-QIFSKFGTVLRIIVFTKNNQFQALLQYAEGASAQAAKVSLDGQNIYNGCCTLRISFSKLTTLNVKYNN DKSRDFTRPDLPSGDGQPTMEHQAMAT-AFG-PGIISASPYTGATHAFPPAFALQPVIQRLSG---LTMSGLP------- GTLASLTLPAGA------RLGFPAIP-AG--HSVVLVSNLNAE---RVTPHCLFILFG-------VYGDVMRVKILFNKK ENALVQMSDSTQAQ-LA--MSHLNGQRLHGRPLRITLSKHTSVQLPR--EGHEDQGLTKDYSSSPLHRFKKPGSKNYSNI FPPS---ATLHLSNIPPSVV-EDDLKMLFSSSGAVVKAFKFFQKDHKMALIQMGSVEEAIECLIQLHNHDLGENHHLRVS FSKSSI- >Anopheles_gambiae_PTBP1 -MFYAICQQ---MGSEELNSLHFLVTMRR--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----RGSDELLSQAAVMAPASDNNNQDLAT---------KKAKLDSTNTVIGMG--------------------ITKTS RVVHIRNIPNEVSEAEIMQLGLPFGRVTNVLVLKGKNQAFIEMGDETAASTMVSVFHANPPPLRGRTVYVQYSNHRELKI DQNH--AIAVTQDLTQSPT-GSPLPLSIEHTNSNSQNASSNNTNNSS----TTPSSGGGGGGGGSGAPNTVLRVIVES-- LLYPVSLDVLH-QIFQRFGKVLKIVTFTKNNSFQALIQYPDAQTAQTARASLDGQNIYNGCCTLRIDNSKLTALNVKYNN DKSRDYTNPSLPSGEPGSDVIASAGGLVSASDLLLLATGQ-RPQLSRDRLVNGLATPGVMP-PFGLGLGTPA-LASAYGG ALPSLNAFALAS----NGALGTPNPANVRGLSNVLLVSNLNDE---MVTPDALFTLFG-------VYGDVQRVKILYNKK DSALIQMAEPYQAY-LA--MTHLDKLRIWNKTIRVMPSKHQAVQLPK--EGQPDAGLTRDYAQNPLHRFKKPGSKNYQNI YPPS---ATLHLSNIPATVT-EDEIKEAFTKNSFEVKAFKFFPKDHKMALIQLSSIEEAVCALIKMHNYQLSESNHLRVS FSKSNI- >Caenorhabditis_elegans_PTBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MTKRGPDDLQLSLRNGVGGASTTAPGVAAAAYYANVMTADSEPKKA KLDPTLYSSQFYTPAMHHGLMTADASTVAAVT------AAANATTAQLLTGNPITQIQGIQLSTLPQCNSTSAVTSIPVS KVVHVRNIPPDLVDVELMQLCIQYGPVSNYMMLKGKSQAFVEYEEEASAAAFVSGMTAVPIQIRGRTLFAQYSTHRELKF DKNKAISDTESVANGSVSNFEVGTQQQP----------------------------------------NSVLRTIIEN-- MMFPVSLDVLY-QLFTRYGKVLRIITFNKNNTFQALVQMSEANSAQLAKQGLENQNVYNGCCTLRIDYSKLSTLNVKYNN DKSRDYTNPNLPAGEMTLEQTIAMSIPGLQNLIPANPYNFAFG--ANPATTFLTTQLAASTAAAAAVNDSANAAALAPYL NPLGLTSANLAP------SISSMRFP-MINLTPVILVSNLHEM---KVTTDALFTLFG-------VYGDVMRVKILYNKK DNALIQYSEPQQAQ-LA--LTHLDKVKWHDRLIRVAPSKHTNVQMPK--EGQPDAGLTRDYAHSTLHRFKKPGSKNYLNI YPPC---ATLHLSNIPTSVS-EEKLKEMFAEAGFAVKAFKFFPKDHKMALCQLEDIETAIDALIAMHNHKLAENAHLRVS FSKSGI- >Homo_sapiens_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDG-IVTEVAVG---------------- ---VKRGSDELLSGSVLSSPNSNMSSMVVT----------ANGNDSKKFKGEDK--------------------MDGAPS RVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKT DNTLNQ-RAQAVLQAVTAVQTANTPLSG--TTVSESAVTP--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLLG-------------------------LPVAAVPGALSP---LAIP NAAAAAAAAAAG------RVGMPGV--SAGGNTVLLVSNLNEE---MVTPQSLFTLF-------GVYGDVQRVKILYNKK DSALIQMADGNQSQ-LA--MNHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-PSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVS FSKSTI- >Pan_troglodytes_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDG-IVTEVAVG---------------- ---VKRGSDELLSGSVLSSPNSNMSSMVVT----------ANGNDSKKFKGEDK--------------------MDGAPS RVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKT DNTLNQ-RAQAVLQAVTAVQTANTPLSG--TTVSESAVTP--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLLG-------------------------LPVAAVPGALSP---LAIP NAAAAAAAAAAG------RVGMPGV--SAGGNTVLLVSNLNEE---MVTPQSLFTLF-------GVYGDVQRVKILYNKK DSALIQMADGNQSQ-LA--MNHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-PSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVS FSKSTI- >Macaca_mulatta_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDG-IVTEVAVG---------------- ---VKRGSDELLSGSVLSSPNSNMSSMVVT----------ANGNDSKKFKGEDK--------------------MDGAPS RVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKT DNTLNQ-RAQAVLQAVTAVQTANTPLSG--TTVSESAVTP--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLL------------------------------AVPGALSP---LAIP NAAAAAAAAAAG------RVGMPGV--SAGGNTVLLVSNLNEE---MVTPQSLFTLF-------GVYGDVQRVKILYNKK DSALIQMADGNQSQ-LA--MNHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-PSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVS FSKSTI- >Mus_musculus_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDG-IVTEVAVG---------------- ---VKRGSDELLSGSVLSSPNSNMSGMVVT----------ANGNDSKKFKGEDK--------------------MDGAPS RVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKT DNTLNQ-RAQVVLQAVTAVQTANTPLSG--TTVSESAVTP--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLL------------------------------AVPGALSP---LAIP NAAAAAAAAAAG------RVGMPGV--SAGGNTVLLVSNLNEE---MVTPQSLFTLF-------GVYGDVQRVKILYNKK DSALIQMADGNQSQ-LA--MNHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-PSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVS FSKSTI- >Felis_catus_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDG-IVTEVAVG---------------- ---VKRGSDELLSGSVLSSPNSNMSSMVVT----------ANGNDSKKFKGEDK--------------------MDGAPS RVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKT DNTLNQ-RAQAVLQAVTAVQTANTPLSG--TTVSESAVTP--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLL------------------------------AVPGALSP---LAIP NAAAAAAAAAAG------RVGMPGV--SAGGNTVLLVSNLNEE---MVTPQSLFTLF-------GVYGDVQRVKILYNKK DSALIQMADGNQSQ-LA--MNHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-PSVAEEDLRTLFANTGGTVKAFKFFSKQAFLSLN----------------------------- ------- >Myotis_lucifugus_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------QDPY-LSQVFILG---------------- ---TKRGSDELLSGSVLSSPNSNMSSMVVT----------ANGNDSKKFKGEDK--------------------MDGAPS RVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAVTMVNYYSAVTPHLRNQPIYIQYSNHKELKT DNTLNQSRAQAVLQAVTAVQTANTPLSG--TAVSESAVTP--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFTKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLLGIPFQEPR---GAQPQVLQPWCLKLGLPVAAVPGALSP---LAIP NAAAAAAAAAAG------RVGMPGV--SAGGNTVLLVSNLNEE---MVTPQSLFTLF-------GVYGDVQRVKILYNKK DSALIQMADGHQSQ-LA--MNHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-PSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVS FSKSTI- >Pteropus_vampyrus_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------IVTEVAVA---------------- ---VKRGSDELLSGSVLSSPNSNMSS-VVT----------ANGNDSKKFKGEDK--------------------MDGAPS RVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKT DNTLNQ-RAQAVLQAVTAVQTANTPLSG--TTVSESAVTP--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLLG-------------------------LPVAAVPGALSP---LAIP NAAAAAAAAAAG------RVGMPGV--SAGGNTVLLVSNLNEE---MVTPQSLFTLF-------GVYGDVQRVKILYNKK DSALIQMADGNQSQ-LA--MNHLNRQKMYGKIIRVTLSKHQ--------------------------------------- -------------------------------------------------------------------------------- ------- >Gallus_gallus_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MAEASGTCTARARDSGA CSVAAKDEERIPVLGDVRQFPCRPRRHFLAGSPCSLVVRLSVPLVSALSCSAMDG-IVTDVAVG---------------- ---VKRGSDELLSGSVLNSPNSNMSSMVVT----------ANGNDNKKFKSEDK--------------------MDGSPS RVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKT DNTLNQ-RAQAVLQAVTAVQATNAPISG--TTVSESAVTP--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLL------------------------------AVPGALSP---LAIP NAAAAAAAAAAG------RVGMPGV--SASGNTVLLVSNLNEE---MVTPQSLFTLF-------GVYGDVQRVKILYNKK DSALIQMADGNQSQ-LA--MSHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-PSVAEEDLRTLFANTGGTVKAFKFFQ-DHKMALLQMSTVEEAIQALIDLHNYNLGENHHLRVS FSKSTI- >Anolis_carolinensis_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDG-IVTDVAVG---------------- ---VKRGSDELLSGSVLSSPTTNMSSIVVT----------ANGNDNKKFKGEDK--------------------MDGAPS RVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKT DNTLNQ-RAQAVLQAVTAVQTTNTPISG--TTVSESAVTP--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLL------------------------------AVPGALSP---LGIP NAAAAAAAAAAG------RVGMPGV--SSGGNTVLLVSNLNEE---MVTPQSLFTLF-------GVYGDVQRVKILYNKK DSALIQMADGNQSQ-LA--MSHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-PSVSEDDLRMLFANTGGTVKAFKFFQ-DHKMALLQMSTVEEAIQALIDLHNYNLGENHHLRVS FSKSTI- >Xenopus_tropicalis_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------LPR-KTAHVSMHT--------------- ---ARRGSDELLSGSVLNGPSSNMSSVVVT----------EVMMESEKAKAKTK--------------------YEKSNE ETLHIRQCPKTLRSNDVTILSQIFHKLLNMLTLTGAVQAFLELATEEAASTMVNYYTTITPHLRNQPIYIQYSNHKELKT DSALNQ-RAQAVLQAVTAVQTSNSSVTS--TAANENTVSS--------------------------AQSPVLRIIIDN-- MYYPVTLDVLH-QIFSKFGTVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLL------------------------------AVPGALSP---LGIP NAAAAAAAAAAS------RVGMHGV--STGGNTVLLVSNLNEE---MVSPQSLFTLFAFLNLKKGVYGDVQRVKILYNKK DSALIQMADGNQSQ-LA--MSHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFSNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-QNITEDDLRTLFTNTGGNVKAFKFFQ-DHKMALLQMSTVEEAIQALIDLHNYNIGDNHHLRVS FSKSTI- >Danio_rerio_PTBP2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDG-IASDVAVG---------------- ---VKRSSDDLLSGSLYSSPNSSVT---------------ANGSDSKKLRVEDSM--------------------DSPPS RVIHIRKLPNEVSETEVIALGLPFGKVTNILMLKGKNQAFLELGTEEAAVTMVNYYTAVTPQVRNVPVFIQYSNHKELKT DSALNQ-RAQAVLQAVSAVQEGGSPSSD--MAS-KSVLTP--------------------------APSPVLRIIIDN-- MFYPVTLDVLQ-QIFSKFGTVMKIITFTKNNQFQALLQFSDPVNAQQAKLSLDGQNIYNSCCTLRIDFSKLVNLNVKYNN DKSRDYTRPELPAGDGQPPVDPSMAAALSKDSPSLLGTP-------SGMVTSYSSGGG-----FPSSLGAISP---LS-- --AAAAAAAAAG------RVALSGH--SVPGG-VLLVSNLNDE---MVTPQSLFTLFG-------VYGDVQRVKILYNKK DSALIQMSDGNQAQ-LA--MSHLNGQKMYGKIIRVTLSKHQTVQLPR--EGLDDQGLTKDFTSSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-DNVTEEDLRLLFSNSGGTVKAFKFFQ-DRKMSLLQMATAEEAIQALIDLHNYDMGRGHRLRVS FSKSTI- >Tetraodon_nigroviridis_PTBP2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------LSGVIISDVAVG---------------- ---VKRGSDELS---MYTSPTSGMSSISDG---------ASNGSDSKKLRVEE-----------------------APPS RVLHIRKLPNEATETEIIALGLPFGKVTNILTLKGKNQAFLEMGTEEAAITMVNYYATVTPHVRNVPVFIQYSNHKELKT D-AGNQ-RTQAVLQAVSAVQSGGSPSSD--VQ---EALAA--------------------------ASSPVLRIIIDN-- MFYPVTLDVLQ-QIFSKFGTVMKIITFTKNNQFQALLQFSDPVNAQQAKLALDGQNIYNSCCTLRIDFSKLVNLNVKYNN DKSRDYTRPELPAGDGQPSLDPAVAAAFSKDSNSLLGKIPG----------------------------ALTP---LS-- --AAAAAAAAAG------RVALAGQ--AGSGG-VLLVSNLNEE---MVTPQSLFTLFG-------VYGDVQRVKILYNKK DSALIQMSDANQAQ-LA--MSHLNGQKMYGKIIRVTLSKHQSVALPR--DGLDDQGLTKDYANSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIP-QNVTEDDLRLLFSNTGGTVKAFKFFQ-DRKMALIQMSTVEEAIQALIDLHNYNMGGNQHLRVS FSKSTI- >Gasterosteus_aculeatus_PTBP2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDG--LGDVAVG---------------- ---VKRGSDELS---MYNSPNSGVSSVSDG---------ASNGSDSKKLRVEE-----------------------APPS RVLHIRKLPNEASETEVIALGLPFGKVTNILTLKGKNQAFLEMGTEEAAITMINYYTTVTPHIRNVPVFVQYSNHKELKT D-AGNQ-RTQAVLQAVSAVQSGGSPSSD--VQ---EALAA--------------------------ASSPVLRIIIDN-- MFYPVTLDVLQ-QIFSKFGTVMKIITFTKNNQFQALLQFSDAINAQQAKLALDGQNIYNSCCTLRIDFSKLVNLNVKYNN DKSRDYTRPELPAGDGQPSLESSVAAAFSKDSNSLLGKIPG----------------------------ALNP---LS-- --AAAAAAAAAG------RVALAGQ--AGSSG-VLLVSNLNEE---MVAPQSLFTLFG-------VYGDVQRVKILYNKK DSALIQMSDANQAQ-LAKAMSHLNGQKMYGKIIRVTLSKHQTVALPR--DGLDDQGLT-DYANSPLHRFRNP-APGFPDI FPPLPRKRTLHNTFISIQDVTEEDLRLLFSNAGGTVKAFKFFQ-DRKMALIQMSTVEEAIQALIDLHNYNMGGNQHLRVS FSKSTI- >Oryzias_latipes_PTBP2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MD----GDVAVG---------------- ---VKRGSDELN---MYSSSPSAMTASSAH---------SANGSDSKKQRLDE-----------------------SPPS RVLHIRKLPNEVTETEVIALGLPFGKVTNILMLKGKNQAFLELGTEEAAITMVNYYTAVTPQVRNTPVFIQYSNHKELKT DSALNQ-RAQAVLQAVSAVQDGSSPSSD--PG--VLELAP--------------------------PPSPVLRIIIDN-- MFYPVTLDVLQ-QIFSKFGTVMKIITFTKNNQFQALLQFSDPVNAQQAKLSLDGQNIYNSCCTLRIDFSKLVNLNVKYNN DKSRDYTRPDLPTGDGDSANNYSLLAAFQVPYFPDYKSPFFSSLARGATYTPVRLIVRKIRYMLPFLSGAISP---LS-- --AAAAAAAAAG------RVALSGS--GVSG--VLLASNLNEE---MVTPQSLFTLFAG------VYGDVQRVKILYNKK DSALIQLSDGNQAQ-LA--MSHLNGQKVFGKVMRVTLSKHQTVALPR--EGLDDQLLTKDFAGSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIR-EGVGEEDLRLLFSNSGGAVKAFKFFHRDRKMALIQMSSVEEAIQALMDLHNYDMGGNHHLKVS FSKSTI- >Oryzias_latipes_PTBP2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDS--VGDIAVG---------------- ---MKRGSDELS---MYNNSNSDLSTRSDG---------ASTGSDSKKLRVEE-----------------------ALPS RVIHIRRLPTEAMDAEVIALGLPFGKVTNILTLRGKNQAFLEMGTEEAAITMVNYYNTVPPHVRNSPVYVQFSNHKELKT D-AASQ-RTQAVLQAVSAVQ---PPGSE--VQ---DVLAA--------------------------ASSPVLRIIIDN-- MFYPVTLDVLQ-QIFSKFGTVMKIITFTKNNQFQALLQYSDPVQAQHAKLALDGQNIYNSCCTLRIDFSKLVNLNVKYNN DKSRDYSRPELPAGDSRPTLDPSVAAALSKDSTPLLCKIPGG--GGGHLIQSCFLKPQGMKIVLSLPPGALNP---LS-- --AAAAAAAAAG------RVALPGQ--AGSGG-VLLASNLNEE---MVTPQSLFTLFG-------VYGDVQRVKILYNKK DSALIQMCDPSQAQ-LVQAMSHLNGQKMYGKIIRVTLSKHQSVALPR--DGLDDQGLTKDFTNSSLHRFKKPGSKNFQNI FPPS---ATLHLSNVL-QDVTEEDLRLLFSNTGGTVKAFKFFQQDRKMALIQMSTVEEAIQALIDLHNYNMGANQHLRVS FSKSTI- >Branchiostoma_floridae_PTBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------STFQ----------------SLDGQNIYNACCTLRIDYSKLETLNVKYNN DKSRDYTRPELPAGDG---QPSLEQA--------MGLG-------------TFDPGP-----PLLSLPSVPGGLTG---S IPLAGTIPNLS-----AASAAARLAG-LQQAGSVLLVSNLNTE---MVTPDALFTLFG-------VYGDVHRVKILFAKK DNALIQMAEPHQAN-TA--MQHLNNLRVWGKNIRVTLSKHNQVQLPK--EGQPDAGLTKDFTSSPLHRFKKPGSKNFLNI YPPS---DTLHLSNIPASTT-EEELIDLFTSTGGAVQAFKFFAKDRKMALLKMSSTEEAVHSLIKMHNYQLSGSNHLKVS FSKGQIS >Homo_sapiens_PTBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MDASPSPFSLPKKLNELS---------------- ---ARRGSDELLSSGIINGPFTMNSSTPST----------ANGNDSKKFKRDR---------------------PPCSPS RVLHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKT DNLPNQARAQAALQAVSAVQSGSLALSG--GPSNEGTVLP--------------------------GQSPVLRIIIEN-- LFYPVTLEVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDFTRLDLPTGDGQPSLEPPMAAA--FGAPGIIS-SPYAG-AAGFAPAIGFPQATGLSVPA--VPGALGP------- --LTITSSAVTG------RMAIPGAS-GIPGNSVLLVTNLNPD---LITPHGLFILFG-------VYGDVHRVKIMFNKK ENALVQMADANQAQ-LA--MNHLSGQRLYGKVLRATLSKHQAVQLPR--EGQEDQGLTKDFSNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVT-VDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVS FSKSTI- >Pan_troglodytes_PTBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MDG------VVTDLITVG---------------- ---LKRGSDELLSSGIINGPFTMNSSTPST----------ANGNDSKKFKRDR---------------------PPCSPS RVLHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKT DNLPNQARAQAALQAVSAVQSGSLALSG--GPSNEGTVLP--------------------------GQSPVLRIIIEN-- LFYPVTLEVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDFTRLDLPTGDGQPSLEPPMAAA--FGAPGIIS-SPYAG-AAGFAPAIGFPQATGLSVPA--VPGALGP------- --LTITSSAVTG------RMAIPGAS-GIPGNSVLLVTNLNPD---LITPHGLFILFG-------VYGDVHRVKIMFNKK ENALVQMADANQAQ-LA--MNHLSGQRLYGKVLRATLSKHQAVQLPR--EGQEDQGLTKDFSNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVT-VDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVS FSKSTI- >Macaca_mulatta_PTBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------ANGNDSKKFKRDR---------------------PPCSPS RVLHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKT DNLPNQARAQAALQAVSAVQSGSLALSG--GPSNEGTVLP--------------------------GQSPVLRIIIEN-- LFYPVTLEVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDFTRLDLPTGDGQPSLEPPMAAA--FGAPGIIS-SPYAG-AAGFAPAIGFPQATGLSVPA--VPGALGP------- --LTITSSAVTG------RMAIPGAS-GIPGNSVLLVTNLNPD---LITPHGLFILFG-------VYGDVHRVKIMFNKK ENALVQMADANQAQ-LA--MNHLSGQRLYGKVLRATLSKHQAVQLPR--EGQEDQGLTKDFSNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVT-VDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVS FSKSTI- >Mus_musculus_PTBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MDG------VVTDLIAVG---------------- ---LKRGSDELLSSGVINGPSTMNSSTSA-----------ANGNDNKKFKGDR---------------------PPCSPS RVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKT DNLPNQARAQAALQAVSAVQSGNLSLPG--ATANEGTLLP--------------------------GQSPVLRIIIEN-- LFYPVTLEVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDFTRLDLPTGDGQPSLEPPMAAA--FGAPGIMS-SPYAG-AAGFAPAIAFPQAAGLSVPA--VPGALGP------- --LTLTSSAVSG------RMAIPGAS-GMPGNSVLLVTNLNPD---FITPHGLFILFG-------VYGDVHRVKIMFNKK ENALVQMADASQAQ-LA--MNHLSGQRLYGKVLRATLSKHQAVQLPR--EGQEDQGLTKDFSNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVT-MDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVS FSKSTI- >Felis_catus_PTBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------FSNLKKSYI-------FLANGNDNKKFKGDR---------------------PPCSPS RVLHLRKIPSDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPVTPHLRSQPVFIQYSNHRELKT DNLPNQAKFSLLLKLFSRTQSGSLKLSG--SETLKGNALT--------------------------EPSPLALCVISQLL VFFSLTIHILH-EIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDFTRLDLPTGDGQPSLEPPMAAA--FGAPGIIS-SPYAG-AAGFAPAIGFHQATGISVPA--VPGALGP------- --LTITSSAVTG------RMAIPGTS-GVPGNSVLLVTNLNPD---LITPHGLFILFG-------VYGDVHRVKIMFNKK ENALVQMADASQAQALA--MNHLSGQRLYGKVLRATLSKHQAVQLPR--EGQEDQGLTKDFSNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVT-VDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVS FSKSTI- >Myotis_lucifugus_PTBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MEKIIENITLA---------------- ---FQRGSDELLSSGIINGPFTMNNSSPSI----------ANGNDNKKFKGDR---------------------PPCSPS RVLHLRKIPSDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAITMVNYYTPVTPHLRSQPIFIQYSNHRELKT DNLPNQARAQAALQAVSAVQSGSLALPG--APTNEGTMLP--------------------------GQSPVLRIIIEN-- LFYPVTLEVLH-QIFSKFGTVLKIITFTKNNQFQALLQYADPLNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDFTRLDLPTGDGHPSLESPMAAA--FGAPGIIS-SPYAG-AAGFAPAIGFPQATGLSVPG--VPGALGP------- --LALTSSAVTG------RMSIPGAG-GIPGNSVLLVTNLNPD---LITPHGLFILFG-------VYGDVHRVKIMFNKK ENALVQMADANQAQ-LA--MNHLNGQRLYGKVLRATLSKHQAVQLPR--EGQEDQGLTKDFSNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVT-MDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVS FSKSTI- >Anolis_carolinensis_PTBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------EKGVVPF-------------------FFLGQE----------------- -----RGSDELFPSGIAYGPLTMSNSTPAT----------ANGNDNKKFKGDR---------------------SPCSPS RVLHLRKIPNDVTEAEVISLGLPFGRVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKT DNLPNQARTQAALQAVSAVQSGGLALTG--APATEGGLPP--------------------------GQSSVLRIIVEN-- LFYPVTLEVLY-QIFSKFGTVLKIITFTKNNQFQALLQYADPLNAHYARMALDGQNIYNACCTLRIDFSKLTSLNVKYNN DKSRDFTRLDLPSGDGQPSLEPTMAAA--FGTPGIIS-SPYAG-AAGFAPAIGFPQAAGLSVQG--VPSALGP------- --LAITTSTMTG------RMAIPGVH-GMPGNSVLLVSNLNPD---AITPDGLFILFG-------VYGDVHRVKIMFNKK ENALVQMADATQAQ-LA--MNHLNGQKLYGKMLRVTLSKHQTVQLPR--EGQEDQGLTKDYSNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPSVT-VDDLKNLFADTGCIVKAFKFFPKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVS FSKSTI- >Xenopus_tropicalis_PTBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------DSIGLDIIPS---------------- ---SHRGSDELLSSGIANGPFTMSHSTPAT----------ANGNDSKKFKGDR---------------------SPCSPS RVLHIRKIPNDVTESEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVSMVNYYTPVPPHVRSQPVYIQYSNHRELKT DNLPNQARAQAALQAVNTLQSGGLTLTS--VPGGEGLVLS--------------------------GQSPVLRIIVEN-- LFYPVTLEVLH-QIFSKFGTVIKIITFTKNNQFQALLQYADPMNAHHAKVALDGQNIYNACCTLRIEFSKLTSLNVKYNN DKSRDFTRLDLPTGDGQPSLDTTMAAA--FGAPGIIS-SPYAG-AAGFAPAIGFPQAVRLSVPG--VP-GLGP------- --LALTTSAITG------RMAIPGMT-AIPGHSVLLVSNLNPD---AILPHGLFILFG-------VYGDVQRVKILFNKK ENALVQMTDATQAQ-LA--MSHLNGQRLHGRVLRITLSKHQSVQLPR--EGHEDQGLTKDYTNSPLHRFKKPGSKNFQNI FPPS---ATLHLSNIPPLVT-DEDLKRLFASTGCSVKGFKFFQKDRKMALIQLGSVEEAILALIELHNHDLGENHHLRVS FSKSMI- >Drosophila_melanogaster_PTBP3 MMSCPIPMP---MPISSLHKSEFEPVNIGVKQMQLLHAPASTHPHPHPHQHPQHSAASAAAYQAMQVHQQQHQQQQQAAV FHHQVAAIAAQQQQQQQQAQVQHQQQMQQQFHYQAQAQAQAQAMLQTYMQLQVNSAVGVSTAPATPTKPVAAQIPGAISG PIAGPVPVSVPTQFFTAPSTPLTIIPAAAVASSAMFATAATPTSAATTPTNNVNNTVNLSAVSRTTTTTTKKQPQAVADA VLSAVGGNVGTAVGGGTISSLLGPEPLPIMPHHLPLASVRGCSSASSGCSSASSDCSMPSPTSLHLSSPKKVRIDEQYIY KLNYLRGSDELLSQAAVMAPASDNNNQDLAT---------KKAKLEPG-TVLAGG--------------------IAKAS KVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKT DQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVES-- LMYPVSLDILH-QIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNN DKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQ-RPSLS----VNGLGAPGVLP-PFALGLGTP--LTGGYNN ALPNLAAFSLAN----SGALQTTAPA-MRGYSNVLLVSNLNEE---MVTPDALFTLFG-------VYGDVQRVKILYNKK DSALIQMAEPQQAY-LA--MSHLDKLRLWGKPIRVMASKHQAVQLPK--EGQPDAGLTRDYSQNPLHRFKKPGSKNYQNI YPPS---ATLHLSNIPSSCS-EDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVS FSKSNI-