>Homo_sapiens_SLC44A1 -------------------------------------------------------------------------------- ------------------------------------------------------------MGCCSSASSAA-------QS SKREWKPLED---------------------------------------------------RSCTDIPWLLLFILFCIGM GFICG--FSIATGAAARLVSGYDSYGNICGQK-NTKLEAIPNS--GMDHTQRKYVFFLDPCNLDLINRKIKSVAL----- -------------------------------------------CVAACPRQELKTLSDVQKFAEIN---GSALCSYN-LK PSEYTT------------SPKSSVLCPKLPVPAS---APIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDN SVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTG------------------VLW WLYAKQRR--------SPKETVTPEQ--------------LQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTI ALFHVAGK---VFIHLPLLVFQPFWTFFALVLFWVYWIMTLLF--LGTT------------------------------- ----------GSPVQN-EQGFVEFKI----------------------------SGPLQYMWWYHVVG----LIWISEFI LACQQMTVAGAVVTYYFTRDK-RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGK---ENACA RCVLKS------CICCLWC-LEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VATINTVG---------- ---------------DFMLFLGKVLIVCSTGLAG-IMLLNYQ--------------QDYTVWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKG------GVADSRELKPMASGASSA--- ----------------------------------------------------------- >Pan_troglodytes_SLC44A1 -------------------------------------------------------------------------------- ------------------------------------------------------------MGCC---------------S SKREWKPLED---------------------------------------------------RSCTDIPWLLLFILFCIGM GFICG--FSIATGAAARLVSGYDSYGNICGQK-NTKLEAIPNS--GMDHTQRKYVFFLDPCNLDLINRKIKSVAL----- -------------------------------------------CVAACPRQELKTLSDVQKFAEIN---GSALCSYN-LK PSEYTT------------SPKSSVLCPKLPVPAS---APIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDN SVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTG------------------VLW WLYAKQRR--------SPKETVTPEQ--------------LQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTI ALFHVAGK---VFIHLPLLVFQPFWTFFALVLFWVYWIMTLLF--LGTT------------------------------- ----------GSPVQN-EQGFVEFKI----------------------------SGPLQYMWWYHVVG----LIWISEFI LACQQMTVAGAVVTYYFTRDK-RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGK---ENACA RCVLKS------CICCLWC-LEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VATINTVG---------- ---------------DFMLFLGKVLIVCSTGLAG-IMLLNYQ--------------QDYTVWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKG------GVADARELKPMASGASSA--- ----------------------------------------------------------- >Macaca_mulatta_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M GFICG--FSIATGAAARLVSGYDSYGNICGQK-NTKLEAIPNS--GMDHTQRKYVFFLDPCNLDLINRKIKSVAL----- -------------------------------------------CVAACPRQELKTLSDVQKFAEMN---GSALCSYN-LK PSEYTT------------SSKSSVLCPKLPVPAS---APIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDN SVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTG------------------VLW WLYAKQRR--------SPKETITPEQ--------------LQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTI ALFHVAGK---VFIHLPLLVFQPFWTFFALVLFWAYWIMTLLF--LGTT------------------------------- ----------GSPVQN-EQGFVEFKI----------------------------SGPLQYMWWYHVVG----LIWISEFI LACQQMTVAGAVVTYYFTRDK-RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGK---ENACA RCVLKS------CICCLWC-LEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VATINTVG---------- ---------------DFMLFLGKVLIVCSTGLAG-IMLLNYQ--------------QDYTVWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKG------GVADARELKPMASGASSA--- ----------------------------------------------------------- >Mus_musculus_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------MGCCSSASAA-------QS SKREWKPLED---------------------------------------------------RSCTDIPWLLLFVLFCIGM GFICG--FSVATGAAARLVSGYDSYGNICGQR-NAKLEAIPNS--GLDHTHRKYVFFLDPCNLDLINRKIKSIAL----- -------------------------------------------CVAACPRQELKTLSDVQKFAEIN---GSALCSYN-IK PSEYTL------------TSKSSGFCPKLPVPAS---APIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDN SVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTVLVILGSLGGTG------------------VLW WLYAKQRR--------SPKEAVIPEQ--------------LQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTI ALFHVAGK---VFIHLPLLVFQPFWTFFALVLFWAYWIMTLLF--LGTT------------------------------- ----------GSAVQN-EQGFVEYKI----------------------------SGPLQYMWWYHVVG----LIWISEFI LACQQMTVAGAVVTYYFTRDK-RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMVLMYIHSQLKGK---ENACA RCMLKS------CICCLWC-LEKCLSYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VAAINTVG---------- ---------------DFMLFLGKVLIVCSTGLAG-IMLLNYQ--------------QDYTVWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKG------GAADARELKPMASGASSA--- ----------------------------------------------------------- >Rattus_norvegicus_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------MGCCSSASAA-------QS SKREWKPLED---------------------------------------------------RSCTDIPWLLLFVLFCIGM GFICG--FSVATGAAARLVSGYDSYGNICGQR-NAKLEAIANS--GLDHTHRKYVFFLDPCNLDLINRKIKSMAL----- -------------------------------------------CVAACPRQELKTLSDVQKFAEIN---GSALCSYN-IK PSEYTL------------TAKSSAFCPKLPVPAS---APIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDN SVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTG------------------VLW WLYAKQRR--------SPKETVIPEQ--------------LQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTI ALFHVAGK---VFIHLPLLVFQPFWTFFALVLFWAYWIMTLLF--LGTT------------------------------- ----------GSAVQN-EQGFVEYKI----------------------------SGPLQYMWWYHVVG----LIWISEFI LACQQMTVAGAVVTYYFTRDK-RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGK---ENACA RCMLKS------CICCLWC-LEKCLSYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VAAINTVG---------- ---------------DFMLFLGKVLIVCSTGLAG-IMLLNYQ--------------QDYTVWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKG------GAADARELKPMASGASSA--- ----------------------------------------------------------- >Felis_catus_SLC44A1 -------------------------------------------------------------------------------- ---------------------------------------------------------------ICKAHSRL-------KS SKREWKPLED---------------------------------------------------RSCTDIPWLLLFILFCIGM GFICG--FSVATGAAARLVSGYDSYGNICGQK-NAKLEAIPNS--GMDHTHRKYVFFLDPCNLDLINRKIKSVAL----- -------------------------------------------CVTACPRQELKTLSDVQKFAEINA--GSALCSYN-LK PSEYTT------------SSKASVLCPKLPVPASVTSAPIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDN SVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTG------------------VLW WLYAKQRK--------SPKETVIPEQ--------------LQIAEDNLRALLIYAISATVFTVLLFLIMLVMRKRVALTI ALFHVAGK---VFIHLPLLVFQPFWTFFALVLFWAYWIMTLLF--LGTA------------------------------- ----------GSAVQN-DQGFVEFRV----------------------------SGPLQYMWWYHVVG----LIWISEFI LACQQMTVAGAVVTYYFTRDK-RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGK---ENACA RCVLKS------CICCLWC-LEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VAAINTVG---------- ---------------EFHLFLTCVLIVCSTGLAG-IMLLNYQ--------------QDYTVWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKG------GVADARELKPMVGGDEEV--- ----------------------------------------------------------- >Myotis_lucifugus_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------SCCKKKNVSR-------DS SKREWKPLED---------------------------------------------------RSCTDLPWLLIFLLFCIGM GFICG--FSVATGAAARLVSGYDSYGNICGQK-NAELESIPNS--GMDHTHRKYVFFLDPCNLDLINRKIKSEAL----- -------------------------------------------CVAACPRQELKTLSDVQKFAEMNA--GSALCHYK-LK PSEYT-------------SSKASSLCPKLPVPASVTSAPIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDN SVLHRLISGVMASKEIILGLCLLSLVLSMILMVIIRYISRVLVWIVTILVILGSLGGTG------------------VLW WLYAKQRK--------SPKETVIPEQ--------------LQIAEDNLRALLIYAISATVFTVILFLIMLFMRKRIALTI ALFHVAGK---VFIHLPLLVFQPFWTFFALVLFWAYWIMTLLF--LGTT------------------------------- ----------GSAVKN-DQGFVEFRV----------------------------SGPLQYMWWYHVVG----LIWISEFI LACQQMTVAGAVVTYYFTRDK-RNLPFTPILASVNRLVRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGK---ENACA RCMLKS------CICCLWC-LEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VAAINTVG---------- ---------------DFMLFLGKVLIVCSTGLAG-IMLLNYQ--------------QDYTVWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKG------GAADARELKPMVGGDEEV--- ----------------------------------------------------------- >Monodelphis_domestica_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------MGCCNSTSAA-------QS SKREWKPLED---------------------------------------------------RSCTDLPWLLLFILFCLGM GFICG--FSIATGAAARLVSGYDSYGNICGQK-NAKVERIPNS--GIDHTHRKYVFFLDPCNVDLVKRKIKSIAL----- -------------------------------------------CVAACPSHELKTMHEVQKFAEKN---GSALCTYN-LK PSEYVT------------HSKASVFCPKLPVPES---APIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVNDN SVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILIILGSLGGTG------------------VLW WLYAKQRK--------SPKETIIPEQ--------------LQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTI ALFHVAGK---VFIHLPLLVFQPFWTFLALLLFWMYWIMTLLF--LGTL------------------------------- ----------GSAIPN-GE-FVEFEV----------------------------SGPLQYMWWYHVVG----LIWISEFI LACQQMTVAGAVVTYYFTRDK-RNLPYTPILGSVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHNQLKGK---ENACA RCMLKS------CICCLWC-LEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VATINTVG---------- ---------------DFMLFLGKILIVCCTALAG-IMLLNYQ--------------QDYTVWVLPLVIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKSMKEAGKG------GAADSRELKPMASGASSA--- ----------------------------------------------------------- >Gallus_gallus_SLC44A1 -------------------------------------------------------------------------------- --------------------------------------------------------------MGCC-SSAA-------QS SKREWKPLED---------------------------------------------------HSCTDVPWLLLFILFCIGM GFICG--FTIATGAAARLLSGYDSYGNICGQK-NVKVEGIVNS--GLDLTQKKYVFFLDPCNIDLVHQKIKSLAL----- -------------------------------------------CVSACPRKELKTLADVQKFAETN---GSTLCSYE-LL PSEYTT------------DPRAAKLCPKYPVPES---APIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDS SVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTVLVILGSLGGTG------------------VLW WLYAKER---------MSASTVET-----------------QIAKENLQALLIYAISATVFTVILLLIMLIMRKRVALTI ALFHVAGK---VFIHLPLLVFQPFWTFFVLILFWTYWTTVLLF--LGTT------------------------------- ----------GNPVPN-EEGFVEFRV----------------------------AGPLKYMWWYHLVG----LIWISEFI LACQQMTVAGAVVTYYFTREK-RNLPFTPILASVNRLVCYHLGTVAKGSFIITLVKIPRMILMYIHTQLKGK---ENACA RCMLKA------CICCLWC-LEKCLTYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VAAINTVG---------- ---------------DFMLFLGKVLIVCSTGLAG-IMLLNYQ--------------RDYTTWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKSMREAGRG------GGAEGRELKPMASGASSS--- ----------------------------------------------------------- >Anolis_carolinensis_SLC44A1 -------------------------------------------------------------------------------- --------------------------------------------------------------MGCCGSAAS-------QS SKREWKPLED---------------------------------------------------RSCTDIPWLLLFILFCIGM GLICG--FSIATGAAARLVSGYDSYGNICGQK-NVKVEGIENS--GLDLTEKKYVFFLEPCNVDLVKRKIKSIAL----- -------------------------------------------CVSACPQSELKTLADVQKFADMN---GSTLCSYE-LK PSEYTT------------DPRADKLCPKLPVPES---APIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDS SVLHRLISGVMTCREIILGLCLLSLVLSMIMMVIIRYISRVLVWILTILVVLGSLGGTG------------------VLW WLYAKQK---------TPSDTLTVDQ--------------LQIAKDNRQALLIYAIAATVFTVILLLIMLVMRKRVSLTI ALFHVAGK---VFIHLPLLVFQPFWTFFALMLFWVYWITVLLF--LGTT------------------------------- ----------GSPVKN-EQGFVEFRV----------------------------AGPLRYMWWYHVVG----LVWISEFI LACQQMTVAGAVVTYYFTREK-RNLPFTPILASVNRLICYHLGTVAKGSFIITLVKIPRMILMYIHTQVKGK---ENACA RCILKA------CICCLWC-LEKCLTYLNQNAYTATAINSTNFCTSAKDAFVILVENALR--VAAINTVG---------- ---------------DFMLFLGKVLIVCSTGLAG-IMLLNYQ--------------RDYTVWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGKEFYMDKVLMEFVENSRKAMKEAGRG------GGPEGRELKPMASGASSS--- ----------------------------------------------------------- >Xenopus_tropicalis_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------ILVFIVFLN-Q GFICG--FSIATGAASRLVSGYDSYGNICGQK-NTKIEGFVNS--GLDHSNHKYVFFLDPCKLDLVNRKIKSIAL----- -------------------------------------------CVSECPREELQTLNDVKKFAETN---GSALCDYS-LT PSQYTT------------DSSASSLCPKLPVPKS---APIPFFHRCAPVNI----------------------------- ----------------------------------------------SCYAKFAEALIT-----------------FVSDN SVLHRLISGVMTSKEIIMGLCLLSLVLSMILMVIIRYISRVLVWIITILVVLGSLGGTG------------------VLW WLYADKKK--------SFNENLPPDQ--------------LQVSKDNLQALLVYAIAATVFTVILLLMMLIMRKRVALTI ALFHVAGK---VFIHLPLLVFQPFWTFFALLLFWVYWVMVLLF--LGTA------------------------------- ----------GDPSTN-EQGFVEFRI----------------------------NGPLQYMWWYHLVG----LIWISEFI LACQQMTIAGAVVTYYFTRNK-NDLPFTPILASVNRLIRYHLGTVAKGAFIITLVKIPRMILMYIHSQLKGK---ENACA RCMLKS------CICCLWC-LEKCLAYLNQNAYTATAINSTNFCTSAKDALVILVENVLR--VAAINTVG---------- ---------------DFMLFLGKILIVSSTGLAG-VMLLNYQ--------------RDYTVWVLPLIIVCLFAFLVAHCF LSIYEMVVDVLFLCFAIDTKYNDGSPGKEFYMDKVLMEFVENSRRAMKEPG--------SAAEGRELKPMVGGSKEM--- ----------------------------------------------------------- >Gasterosteus_aculeatus_SLC44A1_a -------------------------------------------------------------------------------- -------------------------------------------------------------MGCCGSA----------ER TKREWRPLED---------------------------------------------------RSCTDLPWLLLFTVFCVGM GSICS--FTIVTGGAARLVFGYDSYGNTCGRR-NEVIEGVRLS--GLDHTDRKFIFFLDPCNVDIVQRKIKSTAL----- -------------------------------------------CVSLCPTEELKTYQDLKSFAMLN---GSELCSYE-LA GHKYPA------------LPERFSKCPKLPVPPS---KPLPVFNRCTPVDI----------------------------- ----------------------------------------------SCYAKFAEAVVT-----------------FVSDN SVLHRLIAGVAASKEIIIGLCVLALVLSMILMVIIRYISAVLVWILTAMVVLGSLAGTS------------------VLW WLYIDHRLYGNYTTNQVTEEA--------------------ELNRENGQALLVYAGAATAFTIILLLLMLFMRKRVALTI ALFHVAGK---VFIHLPLLTLQPFVTFFALLLFWIYWILVLLF--LGTS------------------------------- ----------GNSVQNEETGLTEFRL----------------------------TGPLQYLTWYHAVG----LVWITEFI LACQQMTVAGAVVTYYFTRDK-NRLPVTPILSSVLRLVRYHLGTVAKGAFIITLVKIPRLFLMYIHNQLKGK---ENACA RCLLKT------CICCLWC-LEKCLNYLNQNAYAATAINSTGFCTSARDAFVILVENALR--VATINAVG---------- ---------------DFVLFLGKVLIVTSTAFAG-VLLLNYQ--------------RDYAEWLLPLIIVCLFSFLVAHCF LSIFEIVVDVLFLCFAIDTKYNDGTPGKEFFMDKALMEFVESSRRLGRAVERGRSRVKAAVSEGAGIKPMVSDSRGG--- ----------------------------------------------------------- >Oryzias_latipes_SLC44A1_a -------------------------------------------------------------------------------- -------------------------------------------------------------MGCCGSS----------ER TKREWRPLED---------------------------------------------------RSCTDLPWFLLFTVFCVGM GSICG--FTIVTGGAARLVFGYDSYGNTCGQR-NELIEGVRLS--GLDHTDRKFVFFLDPCNIDIVQRKIKSVAL----- -------------------------------------------CVSLCPAEELQTYQDLKRFAMVN---GSELCSYE-LA AHKYPG------------LPERIDKCPKLPVPPS---KPLPVFNRCTPVDV----------------------------- ----------------------------------------------SCYAKFAEAVVT-----------------FVGDS SVLHRLIAGVAASKEIIIGLCVLALALSMILMVIIRYISAVLVWILTSLVVLGSLAGTG------------------VLW WLYIDHRLYGNDTSPKLPKEAKEEMK--------------AELSADSGQALLVYAVSASVFTIILLLLMLFMRKRVALTI ALFHVAGK---VFIHLPLLTLQPFVTFLALLLFWIYWILVLLF--LGTS------------------------------- ----------GNPEQNEETGLTEFRL----------------------------TGPLQYLTWYHAVG----LVWISEFI LACQQMTVAGAVVTYYFTRDK-NRLPVTPILSSVLRLVRYHLGTVAKGSFIITLVKIPRLILMYIHNQLKGR---ENVCA RLLLKT------CICCLWC-LEKCLNYLNQNAYAATAINSTSFCTSARDAFVILVENALR--VATINAIG---------- ---------------DFVLFLAKILIMTSTAFAG-VLLLNYQ--------------RDYTEWLLPLIIVCLFSFLVAHCF LSIFEIVVDVLFLCFAIDTKYNDGTPGKEFFMDKALMEFVESSRRLGRAAERGRSRVKEAVSEGAEMKPMAPGTSSA--- ----------------------------------------------------------- >Ciona_intestinalis_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------MGCCYSAARS--MRGDEPP QPSKWKPLEK---------------------------------------------------RSCTDVIPLIVFTLFFIGM MLIAG--FAIVNGAAYRMINGFDSYGNVCSKK-NTPISSHPLS--GLDQTGKPYVFFMNVAN------GYKSLEI----- -------------------------------------------CVSKCPDRELYSMNDVHNFFLET---GSQLCDYS-LP PDQYLSS--------AAAS-STTGPCPVFPVLIKK---ISQVLYRCVPDN------------------------------ ------------------------------------------------IGTFLIDLL-------------------VNSL DPVNRIISDIYLCRYSIIGLCFLSLFVAFIVVLLLRYLASVVVYIINIVVVIASIAGTS------------------MLW WMYATSLN--------SINTAPPE-K--------------LSQSKADSQALLWYSIAATVVTVVLLLLILVMRKRVALTV DLFHEAGK---CMVHMPALMIQPLWTFLVLIMFWMGWVVVFGF--IAFS------------------------------- ----------GTKVMDPIHPGWVRYN---------------------------ATAPIHYMWWYHVVG----LVWVSEFI LACQQMVIAGAVAKHYFTRDK-KKLG-APIISSMGRLISNHLGSCALGSFIIILVKIPRCILMYLSRQIKDS---PNMLA KLMVKC------CICCLWV-LEKCLRYLNYNAYSLVAINGTHFCKSACDAVATLLSNALR--VIAINSVG---------- ---------------AFVLFLGKLLVVAIVAGVGGILVVKFH--------------PNVNYIAAPVGLIAVFSYLTAHCF ISIYEMSIDTLLLCFCEDSRVNDGTPGKEYFMPKSLMTYVKNSSKHISKLEGKSHKNSE----NEESMRLESPNA----- ----------------------------------------------------------- >Ciona_savignyi_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------MGCCYSAAQS--MAGDKPP EPSRWKPLEK---------------------------------------------------RSCTDIIPLAIFFIFFIGM ILIAA--FAIANGAAYRMINGFDSYGNVCGKQ-NKPVTNHHLS--GLDNREKSYVFFMDVLD------ARTSLEI----- -------------------------------------------CVSKCPDRELRTMNDVYNFYLET---GSQLCDYS-YP PDRYLSA--------AVADQSTTGPCPVLPVKIS-----SAILFRCVPDN------------------------------ ------------------------------------------------IGTFIADLVT-----------------MINNL DPISRIVSDIYACRYAIIGLCFLSLLVAFLVVLLLRYMASMVVYIINIVVALSSLAGTA------------------VLW WMYASSRI--------ALEKKAPETK--------------LKSEQENTQAFLWYSIGATIITFVLLLLILVMRKRVALTV DLFYEAGK---CMQHMPTLLLQPLWTFFVLVFFWIGWVVVFGF--IAFS------------------------------- ----------GAFIKPMMVKGFFLHFRL----------------------LIKIQCQFSYMWWYHIVG----LIWVSEFI LACQQIVIAGAVAKHYFTRDK-KNLG-SPIISAMGRLISNHLGSCALGSFIIVLVKIPRCILMFLSRQIKDS---PNLLA KFMVKC------CMCCLWV-LEKCLRYLNYNAYSLVAINGTHFCKSACDAVATLLSNALR--VIAINSIG---------- ---------------AFVLFLGKLLVVAIVAGIGGLLVIKFH--------------PNVHHMAAPVGLIAVFSYLTAHCF ISTYEMAIDTLLLCFCEDCRVNDGSPGKEYFMPKSLM------------------------------------------- ----------------------------------------------------------- >Branchiostoma_floridae_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------MCPRDEE EDERWQPLMD---------------------------------------------------RSCTDVIALVIFILFWVGM FFIAA--YSIAGGNAYRLAYGTDSYGNVCGMK-NEKNANINLKSAGLDMTGRPYVFFMDLFN------PADALEI----- -------------------------------------------CVSKCPDQDLNSIQDVQDFAKNS---SSSLCEYD-VK QENILT-----------AGQSHLGPCPSTPVKAS-----TSFLNRCVPKD------------------------------ ------------------------------------------------APDFLVKFMA-----------------ILNSY DIFYKVLSDVFQARAEIAGMCVLAVVVALLMVALIRFVAGFVMWIFMGIVAVASIVGTA------------------LLW WTYATKNQ--------EYYAVPENER--------------LDENGKDVTAFLVYSIIATIATVVLLIVLIVMRKRVKLVV ALFHEAGK---VFMHTPLLVLQPLWTFIALALFFIYWTAVLVF--LATA------------------------------- ----------GEPTVDTSTGWVTYRD----------------------------PEPVRYMWWYHVVG----LIWTSEFF LACQQMVIAGAVTQVYFTRDK-KQVS-SPILKATGRLISYHLGSVAVGSFIIVLVKIPRLILTYIQAKLKDK---ENSCV QFTLKC------CMCCLWC-LENCLKYLNYNAYTVIAIEGTSFCTAARRAFLALVSNALR--VVAINSVG---------- ---------------DFVLFLGKLGVVAIVGAIS-LIIFRTD--------------ARLHYYAVPILVICVFAFFIAHCF LSVYEMVVDTLLLCFCEDCRINDGSPGREYYMDKSLLEFVENSSEALKNLDKKKKKETANANANEHVELKETMNSSSKAD YV--------------------------------------------------------- >Drosophila_melanogaster_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------MGCAESKDGEG-------- -EAQNNRPKY---------------------------------------------------RSCTDTCWLAIYIIFWLFL IVIAI--FSFVYGNPLRIINGYDSFGNTCGVKYNEKFQGFPLS--GMNTLDKPELFYFDVKELK------KSLKI----- -------------------------------------------CVKSCPAKTMTKGSELLEYYSQT---GTQLCKYD-YN MQQLTT--AGN----DAKTFNFLGPCPSFPVHESS-----PVLHRCVPKGTG---------------------------- --------------------------------------------------EKVQNYYD-----------------MLNNW DVAQQFVGDIYSTWHIIAMVCGLALLISIALVTMMHWLSRIVSWIICVLVIVASVALTV------------------ALW YAYYNIRN--------KSGVNTQYSM--------------LEEFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLS ALFEEAGQ---CMMNLPGLLIAPLLAFLVLIAFLSFWVAVIIC--LATASSPGQSPIAPF-------------------- ---------DNSKAHQQPLPANALFVSN---------STDVNDLR-----QYADAGVLRSMFWIYVVG----LIWTVEFI FACQQFALAAAVAFWYFQ-----KPTSTPTFYAIGKLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECA ACCLKC------CICGFWL-LEKFIRFLNHNAYTVVAIESINFCPAAGIAWNAMATNVLQ--VATINSVG---------- ---------------DFILFLGKVVVAALSGLIG-IVLLKDK--------------PGLNFYMAPVIIIIIFSFFIAHII LSLFEMVVDTLFLCVCEDKTLNGRSGRWAQSNLAKLVGEEPLQPGEEPPIEVVQMMPINKQPFSITRLPQSDPEVAPMSA D---------------------------------------------------------- >Apis_mellifera_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------MSCCSGDDDD--------- -EQRHNPTHV---------------------------------------------------RGCTDIFWLCCFIIFWFLM ILIAA--FALVYGNPLRLINGYDSFGNTCGMKNNPKFGSMELS--GQDTSDKPYLFFLDVHNVT------QSLKI----- -------------------------------------------CVKKCPDRKMTTMNDICKFYKET---GSQLCHDK-PG NNLSVC---------NGNIKNITGSCPEL-VYNSI-----PVLNRCIPKDVG---------------------------- -------------------------------------------------ETVIANLYG-----------------FINSW DIIEQILGDLYKTWREILALSFLAFVLSLFMIAIFHLLAHIVTWIVMILVTVTTIGGSI------------------LLW WTYIEIKK--------TLDKTDPNQL--------------LEESVRNERAFLAFSIIGTIITIILLLLLSIIRKRIEFMT ALFKESAK---CLAELPGLLFQPLLTFIALILFFTFWITVILC--LATANYPGTRSVQMYKN------------------ -------HIFDPLNLSLIGEKNTFIEEKRL-------DFSLDSFKTFTLVEYVDSTWIKYMWWVYIIG----LIWTSEFI ISCQDMVISGAVAHWYFRG---KDASASPVCTAMGNLISYHLGSVACGSFLITLFKLPRLILTYLHAKFEKNK-ETSPCA QCGLKC------CICCFYC-LEKFIRYINHNAYTVVAIEGTHFCNAARIAFTALINNALQ--IAVINGVG---------- ---------------DFILFLGKCFVMAATGSIG-LLFMKQD--------------PRLHFYAAPIFIVCVFAFFIAHCI ISLYETVIDTLFLCICEDKNLNGENGKWRQSALAQIASNTTANGQ-----QAHELVPMNT-------------------- ----------------------------------------------------------- >Anopheles_gambiae_SLC44A1 -------------------------------------------------------------------------------- -------------------------------------------------------------MGCFESKP----------- -DQQVQPVTV---------------------------------------------------RSPTDIFWLVLYVVFWIAL IVIAV--FSFIYGNPLRIINGYDSFGNTCGVRSNDKFSNFPLS--GMNTEDKPYLFFLDIKELR------HTLKI----- -------------------------------------------CVKECPQRELLNAAELYRYYEDR---KTKLCRYD-FN MSMLQTQEANQ----GAKYFDFNGPCPPFPVYQSA-----PVLHRCIPTGVN---------------------------- ----------------------------------------------A-PLQQVKKMYA-----------------LINSW EATQQVFSDLYKAWPTIVLICALSLVFSIVMIALLHWLATIVSWLICIIVVVASVGITG------------------VLW WSYYKAKH--------TLDTDQQLSY--------------LEELVRNEATIYVLAIAATCIMIILLVVIYYLREKLTGLA ALFEEAGK---CMLQLPGLAGPPLLAFLALSVFLAFWVVVVVC--LATANYPGVKPLLPLAQ------------------ -------LEDSASIANDPKLKPELAGKN---------DTSFKSFK---LVEYHDVNVLRHMLWIYIIG----LIWTSEFI FACQQLAIAGAVAFWYFR-----KPTDSPVLLAIAKLVKYHLGSVAKGSLIITIFKIPRLILTYLYAKLKRHQQEGSECA SCCLRC------CICSFWL-LEKFIRYLNHNAYTVIAIEGVNFCPAAKIAWNALVTNALQ--VATINGIG---------- ---------------DFVLFLGKLAVASICGLIS-ILLLRDN--------------PDLHFYMAPVIIITVFAFFIAHII LSLYEMVVDTLFLCVCEDRTINGNSGRWKESNLARLLGEAPEEDAVEAPMQEVQLTPITKQPFSAQFL-QAEMENSKA-- ----------------------------------------------------------- >Homo_sapiens_SLC44A2 -------------------------------------------------------------------------------- --------------------------------------------------------------MGDERPHYYGKHGTPQKY DPTFKGPIYN---------------------------------------------------RGCTDIICCVFLLLAIVGY VAVG--IIAWTHGDPRKVIYPTDSRGEFCG-----------QKGTKNENKPYLFYFNIVKCASP-----LVLLE------ ---FQCPTP--------------------------------QICVEKCPDRYLTYLNARSSRD---------FEYYKQFC VPGFKNN-------KGVAEVLQDGDCPAVLIPSK------PLARRCFPAIHAY--------------------------- -------------------------KG-VLMVGNETTYEDGHGSR-KNITDLVEGAK--------------KANGVLEAR QLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLR-FLAGIMVWVMIIMVILVLGY--------------------GIF HCYMEYSRLRGEAGSDVSLVDLGFQT---------DFRVYLHL-RQT---WLAFMIILSILEVIIILLLIFLRKRILIAI ALIKEASR---AVGYVMCSLLYPLVTFFLLCLCIAYWASTAV--FLSTS-------------NEAVYKIFD--------- --------DSPCPFTAKTCNPETFP--------SSNESRQCPNARCQFAFYGGESGYHRALLGLQIFN-AFMFFWLANFV LALGQVTLAGAFASYYWALRKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAE---NKFA K-CLMT---CLK--CCFWC-LEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLFLLGKLLIVGSVG----ILAFFFFTHRIRIVQDT---APPLNYYWVPILTVIVGSYLIAHGF FSVYGMCVDTLFLCFCEDLERNDGSQERPYFMSPELRDILLKGSAEEGKRAEAEE------------------------- ----------------------------------------------------------- >Pan_troglodytes_SLC44A2 -------------------------------------------------------------------------------- --------------------------------------------------------------MGDERPHYYGKHGTPQKY DPTFKGPIYN---------------------------------------------------RGCTDVICCVFLLLAIVGY VAVG--IIAWTHGDPRKVIYPTDSRGEFCG-----------QKGTKNENKPYLFYFNIVKCASP-----LVLLE------ ---FQCPTP--------------------------------QICVEKCPDRYLTYLNARSSRD---------FEYYKQFC VPGFKNN-------KGVAEVLRDGDCPAVLIPSK------PLARRCFPAIHAY--------------------------- -------------------------KG-VLMVGNETTYEDGHGSR-KNITDLVEGAK--------------KANGVLEAR QLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLR-FLAGIMVWVMIIMVILVLGY--------------------GIF HCYMEYSRLRGEAGSDVSLVDLGFQT---------DFRVYLHL-RQT---WLAFMIILSILEVIIILLLIFLRKRILIAI ALIKEASR---AVGYVMCSLLYPLVTFFLLCLCIAYWASTAV--FLSTS-------------NEAVYKIFD--------- --------DSPCPFTAKTCNPETFP--------SSNESRQCPNARCQFAFYGGESGYHRALLGLQIFN-AFMFFWLANFV LALGQVTLAGAFASYYWALRKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAE---NKFA K-CLMT---CLK--CCFWC-LEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLFLLGKLLIVGSVG----ILAFFFFTHRIRIVQDT---APPLNYYWVPILTVIVGSYLIAHGF FSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNK---TNKKAAES--------------------------- ----------------------------------------------------------- >Callithrix_jacchus_SLC44A2 -------------------------------------------------------------------------------- --------------------------------------------------------------MGNERPHYYGKHRTPQKY DPTFKGPIYN---------------------------------------------------RGCTDVICCVFLLLAIVGY VAVG--IIAWTHGDPRKVIYPTDSRGEFCG-----------QKGTKNENKPFLFYFNIVKCASP-----LVLLE------ ---FQCPTP--------------------------------QICVEKCPDRYLTYLNARSSRD---------FEYYKQFC VPGFKNN-------KGVAEVLRDGDCPAVLIPSK------PLARRCFPAIHAH--------------------------- -------------------------KG-VLMVGNETTYEDGHGSR-KNITDLVEGAK--------------KANGVLEAR QLAMRIFEDYTVSWYWIIIGLVIAMVMSLLFIILLR-FLAGIMVWVMIIMVILVLGY--------------------GIF HCYMEYSRLRGEAGSDVSLVDLGFQT---------DFRVYLHL-RQT---WLAFMIILSILEVIIILLLIFLRKRILIAI ALIKEASR---AVGYVMCSMLYPLVTFFLLCLCIAYWASTAV--FLSTS-------------NEAVYKIFD--------- --------DGPCPLTAKTCNPETFP--------SSNESRLCPNARCQFAFYGGESGYHRALLGLQIFN-AFMFFWLANFV LALGQVTLAGAFASYYWALRKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAE---NRFA K-YLMT---CLK--CCFWC-LEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLFLLGKLLIVGSVG----ILAFFFFTHRIRIVQDT---APPLNYYWVPILTVIIGSYLIAHGF FSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNK---TNKKVAES--------------------------- ----------------------------------------------------------- >Mus_musculus_SLC44A2 -------------------------------------------------------------------------------- --------------------------------------------------------------MGKDSQNYYGKHGTPQKY DPTFKGPIYN---------------------------------------------------RGCTDVICCVLLFLAIVGY VAVG--IIAWTHGDPRKVIYPTDSRGEFCG-----------QKGTKNADKPFLFYFNIVKCANP-----LVLLE------ ---FHCPTP--------------------------------QICVKQCPDRYLTLLSARNTRD---------FDYYKQFC VPGFQNN-------KGVTEILRDGECPAVITPSK------PLAQRCFPAIHAS--------------------------- -------------------------KG-VLMVGNETTYEDGHGAR-KNITDLVEGAK--------------KANKILEAR QLAMQIFEDYTVSWYWIIIGLVIAMVLSLLFIVLLR-FLAGIMVWVMIVMVILVLGY--------------------GIF HCYMEYSRLRGEAGSDVSLVDLGFQT---------DLRVYLHL-RQT---WMAFMIILSILEVVIILLLIFLRKRILIAI ALIKEASR---AVGHVMCSLLYPLVTFFLLCLCIAYWASTSV--FLSTS-------------NTAVYKVVD--------- --------DTACPLLRKTCNPETFP--------LRNESLQCPTARCQFAFYGGESTYHRALLGLQIFN-AFMFFWLANFV LALGQVTLAGAFASYYWAMRKPDDMPAFPLFSAFGRALRYHTGSLAFGSLILAIVQIIRVMLEYLDQRLKAAQ---NKFA K-FLMV---CLK--CCFWC-LEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLFLLGKLLIVGSVG----ILAFFFFTHRIRIVQDT---APPLNYYWVPILTVIIGSYLIAHGF FSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNK---TNKKVAES--------------------------- ----------------------------------------------------------- >Felis_catus_SLC44A2 -------------------------------------------------------------------------------- --------------------------------------------------------------MGGERPHYYGKHGTPQKY DPTFKGPIYH---------------------------------------------------RGCTDIICCVFLLLAIVGY VAVG--IIAWTHGDPRKVIYPTDSRGEFCG-----------QKGTKNANKPYLFYFNIVKCASP-----LVLLE------ ---FQCPTP--------------------------------QICVEKCPDRYLTYLNAHRSQD---------FEYYKQFC VPGFQGN-------KGVAEVLRDGDCPAVLIPSK------PLARRCFPAIHAH--------------------------- -------------------------KG-VLMVGNETTYEDGHGSR-KNITELVEGAK--------------KANGVLEAR QLAMRIFEDYTVSWYWIVIGLVIAMVMSLLFIVLLR-FLAGIMVWVMIIMVILVLGY--------------------GIF HCYMEYTRLRGEAGSDISLVDLGFQT---------DLRVYLHL-RQT---WMAFMIILSILEAVIILLLIFLRKRILIAI ALIKEASR---AVGYVMCSLLYPLVTFLLLCLCIAYWASTAV--FLSTS-------------NEAVYKIFD--------- -------DG-TCQVAGKTCNPETFA--------SSNESRLCPGAHCQFAFYGGESGYHRALLGLQIFN-AFMFFWLANFV LALGQVTLAGAFASYYWALHKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVMLEYLDQRLKAAE---NRFA K-FLMT---CLK--CCFWC-LEKFIRFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLFLLGKLLIVGSVG----ILAFFFFTHRIRIVQDT---APPLNYYWVPILTVIIGSYLIAHGF FSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSPNLKRLLNK---TNKKLAES--------------------------- ----------------------------------------------------------- >Myotis_lucifugus_SLC44A2 -------------------------------------------------------------------------------- ----------------------------------------------------------------RDDDSKLAVWGTPQKY DPTFKGPIYN---------------------------------------------------RGCTDIICCVFLLLAIVGY VAVG--IIAWTHGDPRKVIYPTDSRGEFCG-----------QKGTKNANKPFLFYFNIVKCASP-----LVLLE------ ---FQCPTP--------------------------------QICVEKCPNRYLTYLNARGSPD---------FEYYKQFC VPGFQNN-------KGVAEVLRDGDCPPVLTPST------PLAQRCFPAIHAH--------------------------- -------------------------KG-VLMVGNATTYEDGHGVR-KNITELVEGAK--------------KANGVLEAR QLAMRIFEDYTVSWYWIIIGLVIAMVMSLLFIVLLR-FLAGIMVWVMIVMVILVLGY--------------------GIF HCYMEYARLRGEAGSDISLVDLGFQT---------DLRVYLHL-RQT---WMAFMIILSILEVIIILLLIFLRKRILIAI ALIKEASR---AVGYVMCSLLYPLVTFFLLCLCIAYWASTAV--FLSTS-------------NEAVYKIFG--------- -------DVNTCPVNGKTCSPETFP--------SSNESRLCPGAHCQFAFYGGESAYHRALLGLQIFN-AFMFFWLANFV LALGQVTLAGAFASYYWALHKPDDLPAFPLFSSFSRALRYHTGSLAFGALILAIVQIIRVMLEYLDQRLKAAD---NKFA K-FLMT---CLK--CCFWC-LEKFIRFLNRNAYIMIAIYGTNFCTSAKNAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLFLLGKLLIVGSVG----ILAFFFFTHRIRIIQDT---APPLNYYWVPILTVIIGSYMIAHGF FSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSNLKKLLNK---TNKKPAES--------------------------- ----------------------------------------------------------- >Taeniopygia_guttata_SLC44A2 -------------------------------------------------------------------------------- --------------------------------------------------------------------------GTPQKY DPTFKGPIYD---------------------------------------------------RGCTDIVCCVLLVVAIVGY VVVG--VVAWTHGDPRKVIHPTFRRGQICF-----------FRG--HSYEPPLPSEHLVGRSTIR----RVLIS------ ---PPCPPPV-------------------------------QICVSKCPDRYMTYLTAHGNAAA--------LQYYRNFC TPESKSS-------KKVVKVCRDKECPAMLIPST------SLARRCFPAIQAK--------------------------- -------------------------KG-VIMVGNETTYDDGHGRR-RNVTELLEGAK--------------KANVVLETR QLAMKIFEDYTVSWYWIIIGLVIAMVASLIFIVLLR-FLAGIMVWVMIVMVILVLGY--------------------GIF HCYMEYAKLKGEAGSDVSLADLGFQT---------DLRVYLHL-RQT---WLAFLIILCVLELVIVLLLIFLRKRILIAI ALIKEASR---AVGHIMSSLLFPLCTFFLLCLCIAYWASTAV--FLSTS-------------NEAVYKVFN--------- --------ESACPFSGQTCRPETFN--------TSNVTKLCPDAQCLFAFYGGETAYHKYLIVLQFFN-VFMFFWLANFV IALGQVTLAGAFASYYWAFKKPDDMPAFPLFSAFGRALRYHTGSLAFGSLVLAVVQVIRVTLEYLDHRLKAAE---NKFA K-FLLS---CLK--CCFWC-LEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLFFLGKLLIVGSVG----ILAFFFFTHRIKLVQDT---APPLNYYWVPILTVIVGSYLIAHGF FSVYGMCVDTLFLCFLEDLERNDGSAEKPYFMSQNLRKLLKK---TNKGQPDA--------------------------- ----------------------------------------------------------- >Anolis_carolinensis_SLC44A2 -------------------------------------------------------------------------------- ---------------------------------------------------------MEGEASSKDPDDVDGPHGTPQKY DPTFKGPIYD---------------------------------------------------RGCTDIICCILLLVAIVGY VAVG--VVAWTQGDPRKVIYPTDSRGQFCG-----------QKGTPNENKPFLFYFNIMKCASP-----LVLLE------ ---FQCPTT--------------------------------QICVSKCPDRYLTYLNAYTNGAS----GD--LKYYQQFC LPEFKDLR------KSVTEVLKDGDCPAMLTPSK------PLARRCLPAVSAR--------------------------- -------------------------KG-VVMVGNETTFKDGYGKT-RNVTDLIEGAK--------------KANVVLEAR QVAMKIFEDYTVSWYWIIIGLVIAMVVSLIFIVLLR-FLAGIMVWVMIVLVILVLGY--------------------GIF HCYMEYAQLKGQAGSDVTLSELGFQT---------DLRVYLHL-RQT---WLAFMIILCIVEVIIILLLIFLRKRILIAI ALIKEASR---AIGHVMTSLLFPLCTFFLVCLCIAYWASTAV--FLSTS-------------NEAVYKVFN--------- --------ESECAYAGKTCNPETFN--------TSNITKQCTDARCLFAFYGGETAYHKYLIIFQIYN-VFMFFWLANFV IALGQVTLAGAFASYYWAFNKPDDMPAFPLFSSFGRALRYHTGSLAFGSLILAIVQVIRVILEYLDHRLKAAD---NKFA K-FLL---VCLK--CCFWC-LEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLLFLGKLLIVGSVG----ILAFFFFTHKIKVIQDT---APPLNYYWVPILTVIVGSYLIAHGF FSVYAMCVDTLFLCFCEDLERNDGSPERPYYMSPELREILLKGSLESSKSAESQE------------------------- ----------------------------------------------------------- >Danio_rerio_SLC44A2_a -------------------------------------------------------------------------------- --------------------------------------------------------------MEPEEKNPESKYGEPRKF DPTFKGPIYN---------------------------------------------------RGCTDILCCILFILALLGY FAVG--ILAWSQGDPRKVIYPTESTGQFCG-----------QAGTPLEKKPLLFYFNIMKCASP-----LVLLE------ ---FQCPTT--------------------------------QICVEKCPDKFMTLVNALK-SQS----D---KTYYTQFC KEGVDMTKNA-------PQILSEGLCPSILFPSK------NFTRRCLPALETM--------------------------- -------------------------KGGVVVIGNETQFTVDQGEV-INATDLLNAAK--------------KSNVVVEAR AVAMRIFEDYTQSWHWILLGLVIAMLISLIFILLLR-FLAGVMVWVMIIMVIIVIGY--------------------GIF HCYMQYASLKGQAGSDVTIKDLGLQT---------DFSVYLQI-QQT---WLAFMIILCIVEAVILLLLIFLRKRLLIAI ALIKEASK---AIGHVMSSLFYPLLTYALMSLVIAYWAITAV--FLSTS-------------NEPIYKVFN--------- --------TSNCSYSRATCNPATFN--------TSNVTTECPDAECLFAFYGGETLYHKWLIVFQFYN-LFLFFWCVNFV IALGQVTLAGAFASYYWAFKKPDDMPAFPIFNSLGRALRYHTGTLAFGSLILAIVQVIRVVLEYLDQKLKGAQ---NKFA K-FLLS---CLK--CCFWC-LEKFIKFINRNAYIMVAIYGKNFCTSARDAFFLLMRNIVR--VAVLDKVT---------- ---------------DFLLFLGKLLIVGIVG----ICSFFFFTGKIKIAQDV---TPALNYYWVPILTVVFGAYLIAHGF FSVYAMCVDTLFLCFLEDLERNDGTVDRPYFMPERLMATLKKSNQSPGVTRVAPKTAKI--------------------- ----------------------------------------------------------- >Takifugu_rubripes_SLC44A2_a -------------------------------------------------------------------------------- -----------------------------------------------------------------QDQKLRGGAGEARKF DSNFKGPIHNSL-------------------------------------------------RGCTDVLCCIIFIIALLGY FAVG--IIAWSQGDPRKVIYPTDSRGQFCG-----------QAGTPLEKKPLLFYFNILKCASP-----LVLLE------ ---FQCPTT--------------------------------QLCVERCPDRHLTLVKAKVGNKD----D---REYYRQYC KEGVDFAKLS------PPEILKEGLCPAMLMPSK------AFTRRCLPALGTM--------------------------- -------------------------KGGVVVVGNETVFDAGEGTN-VNASDILEASK--------------KSNAVVEAR QVAMRIFEDYTQSWYWILLGLVIAMVISLIFIVLLR-FLAGIMVWVMIVLVILVIGY--------------------GIF HCYMEFANLKDQPGSDITIRDLGLQT---------DFAVYLQI-RQT---WLAFMIILAIVEVIIILLLIFLRKRLLIAI ALIKEASK---AVGHVMSSLFYPLLTFALLAVVIAYWAITAV--FLSTS-------------NEQVYKVFN--------- --------NSDCAYALDNCNPKTFN--------TSNVSTECPDAECLFAFYGGETLYHKYLILFQFYN-VFLFFWCANFV TALGQVTLAGAFASYYWAFKKPEDIPASPICASLGRALRYHTGSLAFGSLILSLVQVIRVLLEYLDHKLKGAQ---NRFA K-FLLS---CMK--CCFWC-LEKCIKFLNRNAYIMIAIYGKSFCPSARDAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLLFLGKLLIVGIVG----IFSFFFFSGKIKAVEDA---APSLNYYWVPILTVVVGSYLIAHGF FSVYAMCVDTLFLCFCEDLERNDGSAERPYFMSPELHEILSKTKPLEE-------------------------------- ----------------------------------------------------------- >Tetraodon_nigroviridis_SLC44A2_a -------------------------------------------------------------------------------- ---------------------------------------------------------------MFTISPSLCRSGEARKF DPNFKGPIHN---------------------------------------------------RGCTDVLCCILFIIALLGY FAVG--IIAWSQGDPRKVIYPTDSRGQFCG-----------QAGTPLEKKPLLFYFNILKCASP-----LVLLE------ ---FQCPTT--------------------------------QLCVERCPDRHLTLVKAKVGNKD----D---GEYYRQYC KEGVDFAKLM----QSPPEILKEGLCPAMLMPSK------AFTRRCLPALGTL--------------------------- -------------------------KGGVVVVGNETVFDAGEGTN-VNASDVLEASK--------------KSNAVVEAR QVAMRIFEDYTQSWHWILLGLVIAMIISLIFIVLLR-FLAGVMVWVMIVLVILVIGY--------------------GIF HCYMEFASLKGQPGSDVTIRDLGLQT---------DFAVYLQI-RQT---WLAFMIILAIVEVIIILLLIFLRKRLLIAI ALIKEASK---AVGHVMSSLFYPLLTFALLAVVIAYWAITAVY-FLSTS-------------NEQVYKVFN--------- --------KSECAYALDTCHPETFN--------TSNVSAECPGAECLFAFYGGETLYHKYLILFQFYN-VFLFFWCANFV TALGQVTLAGAFASYYWAFKKPEDIPSSPIFASLGRALRYHTGSLAFGSLILSLVQVIRVLLEYLDHKLKGAQ---NRCA K-FLLS---CLK--CCFWC-LEKCIKFLNRNAYIMIAIYGKSFCPSARDAFFLLMRNIIR--VAVLDKVT---------- ---------------DFLLFLGKLLIVGIVG----IFSFFFFSGKIKAVEDA---APSLNYYWVPILTVVVGSYLIAHGF FSVYAMCVDTLFLCFCEDLERNDGSAERPYFMSPELHEILSKTARVEEDKDGVEQ------------------------- ----------------------------------------------------------- >Gasterosteus_aculeatus_SLC44A2_a -------------------------------------------------------------------------------- ------------------------------------------------------------------MTKYDRQ-GESRKF DPNFKGPLHN---------------------------------------------------RGCTDVLCCILFILALLGY FAVG--IVAWSQGDPRKVIYPTDSRGQFCG-----------QAGTPLERKPLLFYFNILKCASP-----LVLLE------ ---FQCPTT--------------------------------QLCVESCPDRHLTLVKAKLGSKE----D---REYFQQYC KDGVNFAKLS------PPEILKDGLCPAMLMPSK------AFTRRCLPALGTL--------------------------- -------------------------KGGVVVVGNETTFDAGQGYN-INATDVLEASK--------------KSNVVVEAR QVAMRIFEDYTQSWHWILLGLVIAMVVSLIFIVLLR-FLAGIMVWVMIVLVILVIGYAK------------------GIA HCYMEFASLKGDPGSDVTIRDLGLQT---------DFSVYLQI-RQT---WLAFMIILAIVEIVVILLLIFLRKRIMIAI ALIKEASR---AVGHVMSSLLYPLLTFALLAVVIAYWAITAV--FLSTS-------------NDQVYKVFN--------- --------NSDCEYARETCNPKTFN--------TSNVSAVCPDAECLFAFYGGETLYHKYLILFQFYN-VFLFFWCANFV TALGQVTLSGAFASYYWAFKKPDDIPAFPIFSSLGRALRYHTGSLAFGSLILSMVQVIRVHLEYLDHKLKGAQ---NKFA K-FLLS---CMK--CCFWC-LNRCIKFLNRNAYIMIAIYGKSFCPSARDAFFLLMRNIVR--VAVLDKVT---------- ---------------DFLLFLGKLLIVGIVG----IFSFFFFSGRISAIEDA---APSLNYYWVPILTLVVGSYLIAHGF FSVYAMCVDTLFLCFLEDLERNDGSAERPYFMSQKLLDLLKKSN--EQAKSG---------------------------- ----------------------------------------------------------- >Oryzias_latipes_SLC44A2_a -------------------------------------------------------------------------------- ---------------------------------------------------------------SESDKCSASLIGEPRKY DPNFKGPIEK---------------------------------------------------RGCTDIVCCILFIICVLAY IAVG--ILAWSQGDPRKAIYPTDSRGQFCG-----------QAGTPLQNKSMVFYFNILKCASP-----MVLLE------ ---FQCPTT--------------------------------QMCVEKCPEKYMTLLSAYP-IKK----D---FDYYKNFC QEGVTNSMGV-------PEILKRGLCPAVLIPSKS----CEWNKRLKPAADDE--------------------------- -------------------------NG-KVTVGGQDKVNDGEGNT-VPAEDLLYGVK--------------NATVVIEAR QVVMKIFEDYTHSWYWILIGLAIAMVLSLLFIILLR-YLAAIMVWVVIALLILVIGY--------------------GIV HCYMEYASLKGEPGANVTLQELGFQT---------DFAVYLQL-QQT---WLAFMIILAIVEVIIILLLIFLRKRILIAI ALIKEASR---AIGHVMCSLFYPLFTFLLLALVIAYWAVTAV--FLSTS-------------NQPIYKVFN--------- --------ESACEYSRQTCSPANFS--------DSPEKKACPDSQCLFAFYGGETPYHKYLIVLQFYN-VFLFFWCANFV IALGQMTLAGAFASYYWAFSKPDDIPTFPVFSSLGRSLRYHTGTLAFGALILSIVQLIRVLLEYLDHKLKGAQ---NKFA K-FLLC---CLK--CCFWC-LEKIIKFLNRNAYIMVAIYGKNFCTAAKDAFFLLLRNMIR--VAVLDKVT---------- ---------------DFLLFLGKLLVVGLVG----IFAFFFFSGRVKAFADT---APNLHYYWVPILTVAVGSFLIASGF FSVYSMCVDTLFLCFLEDLERNDGSAEKPYLMPENLRKILNKKNTAQPGQ------------------------------ ----------------------------------------------------------- >Branchiostoma_floridae_SLC44A2 -------------------------------------------------------------------------------- --------------------------------------------------------------MGKDNEGEEKKYGDPAKF DPEFKGPIEN---------------------------------------------------RSCTDIICCLLFIIFIAGF LAVG--ILAWVHGDPKLLLYPTDSQGNLCG-------------NGNYASKPNLHFFNLLDCAGF-----ASVLDGCPTPQ VCVAACPTEYWAFAVELVKMTAGGQADYDKFICTNDVNITGAVCVATCPTEYWAYAIETAKMGLGQ-EPDWSKFICVEGV NVGSGAGLTA----AQIEQYVKDQKCAAYTVPSK------AYGGRCIPSLVET--------------------------- -------------------------IATTVLTTSADDIPLVDSAGNNVTNSKISAGTA-------------ALALILSAQ EVVQEIFTDMVSSWYLILGGLGAAMVVSFIYIVIMR-WIAGVMVWFTIFAVIVLNIF--------------------GIY YCYTQYVALENVSGADSSIYDVGFTT---------NLSTYTKL-QDT---WLGIGIALSVILLIILLILIFLRNRIRIAI ALIKESS------------------------------------SFLASS-------------GQAQYEVQD--------- -------YNTTNTSTASNMTGQSCTPT--TFDTS----AVSDSVQCAFVKYGATSLYYQNLFYLQIFN-LFGLFWVMNFI VALGQCTLAGAFASYYWAFTKPKDIPTFPLTASFGRSLRYHLGSLAFGSFIIAVVQIIRVMLEYIDHKLKDSE---NRAA K-FLLK---CLK--CCFWC-LEKLLKFLNKNAYIMIAIYGKNFCVSAKKAFFLIMRNILR--VAAVTSVTNFLFLLSKLV VTGAIGQVAIVSSVADFLLFLAKMIVVVLFG----TLSFYFFTGKIVFAA--E-YVPNLKYYMVPIIVVVIGAYMVAACF FSVYNMAVDTLFLCFLEDLERNDGSPEKPYYMSKELMSILGKKNRKEGEKEKKGCCGCC--------------------- ----------------------------------------------------------- >Homo_sapiens_SLC44A3 -------------------------------------------------------------------------------- -------------------------------------------------------------MHCLGAEYLV---SAEGAP RQREWRPQIY---------------------------------------------------RKCTDTAWLFLFFLFWTGL VFIMG--YSVVAGAAGRLLFGYDSFGNMCGKK-NSPVEGAPLS--GQDMTLKKHVFFMNSCNLEVKGTQLNRMAL----- -------------------------------------------CVSNCPEEQLDSLEEVQFFANTS---GSFLCVYS-LN SFNYTH------------SPKADSLCPRLPVPPS---KSFPLFNRCVPQTP----------------------------- ----------------------------------------------ECYSLFASVLI--------------------NDV DTLHRILSGIMSGRDTILGLCILALALSLAMMFTFRFITTLLVHIFISLVILGLLFVCG------------------VLW WLYYDYTN-------------DLSIE--------------LDTERENMKCVLGFAIVSTGITAVLLVLIFVLRKRIKLTV ELFQITNK---AISSAPFLLFQPLWTFAILIFFWVLWVAVLLS--LGTA------------------------------- -----------GAAQVMEGGQVEYKP----------------------------LSGIRYMWSYHLIG----LIWTSEFI LACQQMTIAGAVVTCYFNRSK-NDPPDHPILSSLSILFFYHQGTVVKGSFLISVVRIPRIIVMYMQNALKEQ--QHGALS RYLFRC------CYCCFWC-LDKYLLHLNQNAYTTTAINGTDFCTSAKDAFKILSKNSSH--FTSINCFG---------- ---------------DFIIFLGKVLVVCFTVFGG-LMAFNYN--------------RAFQVWAVPLLLVAFFAYLVAHSF LSVFETVLDALFLCFAVDLETNDGSSEKPYFMDQEFLSFVKRSNKLNNARAQQDKHSLRN-EEGTELQAIVR-------- ----------------------------------------------------------- >Pan_troglodytes_SLC44A3 -------------------------------------------------------------------------------- -------------------------------------------------------------MHCLGAEYLV---SAEGAP RQREWRPQIY---------------------------------------------------RKCTDTAWLFLFFLFWTGL VFIMG--YSVVAGAAGRLLFGYDSFGNMCGKK-NSPVEGAPLS--GQDMTLKKHVFFMNSCNLEVKGMQLNRMAL----- -------------------------------------------CVSNCPEEQLDSLEEVQLFANTS---GSFLCVYS-LN SFNYTH------------SPKADSLCPRLPVPPS---KSFPLFNRCVPQTP----------------------------- ----------------------------------------------ECYSLFASVLI--------------------NDV DTLHRILSGIMSGRDTILGLCILALALSLAMMFTFRFITTLLVHIFISLVILGLLFVCG------------------VLW WLYYDYTN-------------DLSIE--------------LDTERENMKCVLGFAIVSTGITAVLLVLIFVLRKRIKLTV ELFQITNK---AISSAPFLLFQPLWTFAILIFFWVLWVAVLLS--LGTA------------------------------- -----------GAAQVMEGGQVEYKP----------------------------LSGIRYMWSYHLIG----LIWTSEFI LACQQMTIAGAVVTCYFNRSK-NDPPDHPILSSLSILFFYHQGTVVKGSFLISVVRIPRIIVMYMQNALKEQ--QHGALS RYLFRC------CYCCFWC-LDKYLLHLNQNAYTTTAINGTDFCTSAKDAFKILSKNSSH--FTSINCFG---------- ---------------DFIIFLGKVLVVCFTVFGG-LMAFNYN--------------RAFQVWAVPLLLVAFFAYLVAHSF LSVFETVLDALFLCFAVDLETNDGSSEKPYFMDQEFLSFVKRSNKLNNARAQQDKHSLRN-EEGTELQAIVR-------- ----------------------------------------------------------- >Macaca_mulatta_SLC44A3 -------------------------------------------------------------------------------- -------------------------------------------------------------MHCLGAEYLV---SAERAP RQREWRPQIY---------------------------------------------------RKCTDTAWLFLFFLFWTGL VFIMG--YSVVAGAAGRLLFGYDSFGNVCGKK-NSPVEGAPLS--GQDMTLKKHVFFMNSCN-QVKGMRLDRTAL----- -------------------------------------------CVSSCPEEQLDSLEEVQLFANTS---GSFLCVYS-LN SSNYTH------------SPKADSLCPRLPVPPS---KSFPLFNRCIPQTP----------------------------- ----------------------------------------------ECYSLFASVWI--------------------NDG DTLHRILSGIMSGRDTILGLCILTLALSLAMMFTFRFITTLLVNIFISLVILGLLFVCG------------------VLW WLYYDYTN-------------DLSIE--------------LDTERENMKCVLGFAIVSTGITAVLLVLIFVLRKRIKLTV ELFQITNK---AISSAPFLLFQPLWTFAILIFFWVLWVAVLLS--LGTA------------------------------- -----------GAAQVMEGGQVEYKP----------------------------LSGIRYMWSYHLIG----LIWTSEFI LACQQMTIAGAVVTCYFNRSK-NDPPDRPILSSLSILFFYHQGTVVKGSFLIPVVRLPRIIVMYMQNALKEQ--QHGALS RYLFRC------CYSCFWC-LDKYLLHLNQNAYTTTAINGTDFCTSAKDAFKILSKNSSH--FTSINCFG---------- ---------------DFIIFLGKVLVVCFTVFGG-LMAFNYN--------------RAFQVWAVPLLLVAFFAYLVAHSF LSVFETVLDALFLCFAVDLETNDGSSEKPYFMDQEFLSFVKRSNKLNNARARQDEHSLRN-DEGTELQAIAR-------- ----------------------------------------------------------- >Mus_musculus_SLC44A3 -------------------------------------------------------------------------------- ---------------------------------------------------------MPGTMQCLGAEYLV---SAE-KT RQREWRPQIY---------------------------------------------------RKCTDTPWLVLFFLFWTGL VFIMG--YSVVAGAAGRLLFGYDSFGNVCGKK-NSPVEGAPLS--GQDMTLKKHVFFMNACNLEVKDRGLGPTAL----- -------------------------------------------CVSSCPEKQLDTLEEVQLFANIN---GSFLCVYS-LN SFNYTQ------------SSSADTLCPRLPVPPS---KPFPLFNRCIPQTP----------------------------- ----------------------------------------------ECYSLFASVLI--------------------NDA DALHRILSGIMAGRDTILGLCVFTFALSLAMLFAFRFISTLLIHIIISLVILGLLFVCG------------------VLW WLYYDYTN-------------DLSTE--------------LDTEKENMNCMLAFAIISTVVTVLLLALIFTLRKRIKLTV ELLHVTNK---AISSCPFLLFQPLWTCAILIFFWVLWVAVLLS--LGTA------------------------------- -----------GTAQVMEGGQVEYKP----------------------------LSGIRYMWWYHLIG----LIWTSEFI LACQRMTVAGAMVACYFNRNQ-NDPPARPILSSLFVLFCYHQGTAVKGSFLLTVTRIPRVIFMCIYSTLKEPQ--RSAWS RGEFRC------SHCGLWC-LLKYLYHLNQDAYTATAINGTDFCTSAKDAHTIIAKNSSH--LTSVNCFG---------- ---------------NFVIFLGKVLVVCFSIFGG-LMAFNYS--------------RALQVWAIPLLLVAFFACVVAHSF LSVFETALDILFLCFAVDLETNDGSSEKPYFMDPGFLSVIKRTNNLNNAKSQGQKDALPN-EEGTELQPIVR-------- ----------------------------------------------------------- >Canis_familiaris_SLC44A3 -------------------------------------------------------------------------------- -------------------------------------------------------------SVCLDSVWKA---SAERTP RPREWRPQLY---------------------------------------------------RKCTDTTWLFLFFLFWTGL MFITG--YSVAAGATARLLFGYDSFGNVCGKK-NSPVEGAPLS--GQDMTLKKHVFFMNACNLEVKDVRLSSTIL----- -------------------------------------------CVSSCPEEQLDTLEEVQLFADNN---GSFLCVYS-LD SINYTQ------------NPNADSLCPSLPVPPS---KSFPLFNRCVPRTP----------------------------- ----------------------------------------------ECYSSFASVLI--------------------NDV DILHRILSGIMSGRDTILGLCILALALSLGMMFTFRFITTLLVQIFIALIISGLLLVCG------------------VLW WLYYDYTH-------------DLSIE--------------LDTERENMKCLLGFAIVSTVITAVVLSLIFVFRKRIKLTT ELFQVINK---AISSSPFLLFQPLWTFAILIFFWVLWVAVLLS--LGTA------------------------------- -----------GAAQVIEGGQVEYQP----------------------------LVGIRYMWWYHLIG----LIWTSEFI LTCQQMTIAGALVTCYFNRNK-NDPPDRPILWSLSILFCYHQGTAIKGSFLMTVTRIPRTILMYLHNTLKDKQ--HGAWS RCMFRC------CFCCFWC-LDKCLRQLTQNAYTATAINGTDFCTSAQDVLKLSSKNSNH--FTSVNCFG---------- ---------------DFIIFLGKVLVVCFTVFGG-LMAFNYN--------------RALQVWAIPLLLVAFFAYLVAHCF LSVFETVLDALLLCFAVDMETNDGSSEKPYFMDQEFLSFVKRIDKLNAARAQGEESSLRN-EEGTELQAVV--------- ----------------------------------------------------------- >Felis_catus_SLC44A3 -------------------------------------------------------------------------------- -------------------------------------------------------------MQCPGAEYLV---SAERTP RKREWRPQIY---------------------------------------------------RKCTDTTWLFLFFLFWTGL LFIMG--YSMVAGATGRLLFGYDSFGNVCGKK-NSPVEGAPLS--GQDMTLKRHVFFMNSCNPEVKDVRLSSTIL----- -------------------------------------------CVSSCPEEQLDTLEEVQLFADKN---GSFLCVYS-LN SINYTQ------------NPNADSLCPRLPVPPS---KSFPLFNRCVPQTP----------------------------- ----------------------------------------------ECYSLFASVLI--------------------NDV DTLHQILSGIMSGRDTILGLCILALALSLAMMFTFWFITTLLVHIFIALTISGLLFVCG------------------VLW WLYYDYTH-------------DLSIE--------------LDTERENMKCLLGFALVSTVITAVLLSLIFVFRKRIKLTV ELFQVINK---AISNSPFLLFQPLWTFAILIFFWVLWVAVLLS--LGTS------------------------------- -----------GAAQVIEGGQVEYKP----------------------------ILGIRYMWWYHLIG----LIWTSEFI LACQQMTVAGALVTCYFNRNK-NDPPDRPILWSLSTLFCYHQGTAIKGSFLITVARIPRTILKYIYNTLKDK---HNAWS TYMFRC------CFCCFWC-LDKCLCHLNQNAYAATAINGTDFCTSAKDALKLLSKNSSH--FTSVNCFG---------- ---------------DFIIFLGKVLVMCLTVFGG-LMAFNYN--------------RALQVWAVPLLLVAFFAYFVAHSF LSVFETVLDALFLCFAADLETNDGSSEKPYFMDQEFLSFVKRINKLKDTRAQGEENSLRN-EEGTELQPVV--------- ----------------------------------------------------------- >Monodelphis_domestica_SLC44A3 -------------------------------------------------------------------------------- -------------------------------------------------------------MPCFGGEYLV---SAEESP RQREWRPQIY---------------------------------------------------RKCTDPAWLILFFLFWTGL MFIMG--YSVIAGAAGRLVFGYDSYGNVCGKK-NSPVEGAPLS--GQDMTKKKHVFFMNSCYLELKDLQINSIAL----- -------------------------------------------CVSSCPEQQLDTLEDVQLFAKNN---GSFLCVYN-LN FANYTQ------------NLSAASLCPRLPIPPS---KSFPLFNRCIPQTP----------------------------- ----------------------------------------------ECYSVFASVLI--------------------NDV DSLHRTLSGIMSWKDTILGLCILAIALSLIMMFILRFITTLLLHIFISLVVLGLLFVSG------------------ILW WLYYDYIN-------------DLSIE--------------LDTERENMKCLLAFAIISTVITVVLLILIFVLRERIQLTV DLFQVTSK---TISNTPFLLLQPLWTFIILIFFWVLWVAVLLS--LGTA------------------------------- -----------GTAQVMAGGRVEYQL----------------------------LSGIRYMWWYHLIG----LIWTSEFI LACQQMTIAGAVVTCYFNRNK-SDPPRRPILSSLVTLFYYHQGTVVKGSFLITMVRIPRTVFTYLSNTLKEKE--DSACT KYIHKC------CFCCLWC-LDKCLSHLTQNAYIATSINGTDFCTSAKDTLSILSKNPGH--VASITCLG---------- ---------------DFIIFLGKMFVVYFTVFGG-LMAFNYH--------------RELQVWAIPLLLVAFFAYLVAHNF LSAFETVLDTLFLCYVIDMETNDGSPEKPYFMDQELMSFVNRSSKLIDSRIRRNRKSLGN-EDGTELQPIVR-------- ----------------------------------------------------------- >Gallus_gallus_SLC44A3 -------------------------------------------------------------------------------- -------------------------------------------------------------MARPGERRQE---SVECVS ELREWRPVVS---------------------------------------------------RKCTDPLWLLLFFLFWAGL MFVTG--YAVMAGAAERLVLGYDSFGNICGRK-NVPVKGVPLS--GRDMTNKKYVFFLNSCSPEMQSPKISSVSL----- -------------------------------------------CVSSCPQEQLNSLEDLQSFARNN---GSCLCVYN-LS ISSYTL------------NPKAAELCPTLPVPPS---KSFPLFNRCVPQHP----------------------------- ----------------------------------------------ECYSKYASVLIS-----------------MVNEM DVFHRILSGILAGRDTVIGLSVLALAFSFIVVLTFRFIRTLLVHTLIALVVFGLLFVSG------------------VLW WLYYDYRN-------------DPSTE--------------LETEKENVKFLFGYAIFSTAVTVVLLSLILVLRKRLQFTV QLFQIVGK---IMGRIPFLLFQPLWTFLILIIFWVFWVAVLLS--LGTA------------------------------- -----------GTAQTTSEGQVEYRA----------------------------FSGICYMAWYHFIG----LIWTSEFI LACQQMTVAGAVVTCYFNRNK-NSPPRHPVLSSISVLLCYHLGTVVKGSFLITILRIPRIVLLYLYNILKQK---ESTCA KCLLKC------CFCWLWC-QESCLRYVNQHVYTTTAINGTNFCTSAKDAVFILTKSSAE--LASISCFG---------- ---------------GFIIFLGKVFVVCFTVFGG-LMAFNYH--------------RELQAWVVPLLLVGFFAYLMSHSF LSVFEVTLDTTFLCFAIDMETNDGSAEKPYFVDQELLMFVNQNNKLTDRQKHG--SMRRGSEDGTELQPMT--------- ----------------------------------------------------------- >Pelodiscus_sinensis_SLC44A3 -------------------------------------------------------------------------------- -------------------------------------------------------------LHYLGILHIV---SVDGIS GQREWRPLIY---------------------------------------------------RKCTDVLWLILFFLFWAGL MFITG--YAVTAGAAERLVFGYDSYGNVCGRK-NTPVEGAPLS--GQDMTNKKHVFFLNSCTLEIKQLKINSIAL----- -------------------------------------------CVSSCPQEQLNSLEDIQLFAKNN---GSCLCVYN-LN ISSYTL------------NPKAAELCPTLPVPPS---KSFPLFNRCVPQNP----------------------------- ----------------------------------------------ECYSQFASVLIN-----------------GVNEA DIFHRILSGIMAGRDTVIGLSVLALAFSLIMVLTFRFITTLLVHIFITLVVFGLLFVSG------------------ILW WLYYDYAN-------------DPSIE--------------LETQKENVKFLLGFAIISTVITIILLSLIFVLRKRIQLTV QLFQIANK---LIGRVPLLLFQPLWTFLILIFFWVFWVAVLLS--LGTA------------------------------- -----------GNAQVISGGQVEYKI----------------------------LSGIRYMWWYHLIG----LIWTSEFI LACQQMTIAGVVVTCYFNRNK-SSLPRHLILSCISVLFCYHQGTVVKGSFLISVVRIPRIIFMSLYDALKEK---EGACA RCMFKC------CFCCFWC-LERCLKYFNQHVYTTTAINGTNFCTSTKDALSILAKNSAS--IAFINFFG---------- ---------------DFIIFLGKVFVVCFTVFGG-LMAFNYH--------------REFHVWVVPLLLVALFAYLVAHSF LSVFEVVMDALFFCFAVDMETNDGSPEKPYFMDQQLLSFVNQSTKLTEGRKNRNPKTPPNSEDGTELQPMVRQEQRQSSE DIK-------------------------------------------------------- >Caenorhabditis_elegans_SLC44A3 -------------------------------------------------------------------------------- -------------------------------------------------------MGRKKHRTIPAVEVYEKSDGFPMPT APPMSPSRMDGVYPSHHVPPLHQAYHVQPASANHVPDQIARFNVIKPDRLAKRHNPQLYTKRGCTDVFCCFLFFVFLCGW VVVAG--FGIMWGDPQRLIYPTDSEFRRCGVN--------LEGSYNFSKRPYLFYFDLTKCISY-----ATALG------ ----GCQTT--------------------------------QLCVKECPSTYFSYLQLRTASVS----EIQNKMKSVVYC TDDVDKTTVTTF--QALQNLVQRGKCVSYTVKSVP----VPVLQRCFPEAIFNAVD-N---------------------- ------------------------VNNVLNSSNSLDYLKRTFGDDALIPQDIQITGQSSE-----------VMKSVVEDQ PVTHKVIHDLSQTWWQTLILIFAAGILSFIWTVIMR-LLGSLIIWLSILIVLVALGF--------------------GAG FSWLKWNTLKTTGAIDDYSFHP-------------AFDAYFEM-PTT---WLVVAIATSVLLLIFLLVILFIRQRISIAC ALISESSK---AIGSMMSTLLFPLFPFLLHIGVFALWGSIAIW--LASS-------------GQEVCRLKET-------- -------NGQVYNTSTKCDCTAKVTG----------------------CTYVGIEKESETIFWLQVYN-LFAFFWLSCFV TALGDIALAGAFASYYWARDKRHDVPTFPVIRALNRAIRYNLGSIAFGSLIIAIVKIIRVLLEYIDHKLGKSQ---NKAV KWFLMC----LK--CCFWC-LEVFFKFLTKNAYIMIAIYGKNFFSSAKDSFLLITRNIVR--TVVVHKVAG--------- ----------------ILLFLGKSMITLGMG----ILSFYYFSGRWVVEGVP---KVDLYYYFVPIVIVVIGSYFMADLF FDVYEMAVDTTFICFLEDSEQNDGSLERPFFMSEKLLEILGNKNDIPLHSK----------------------------- ----------------------------------------------------------- >Homo_sapiens_SLC44A4 -------------------------------------------------------------------------------- -------------------------------------------------------------MGGKQRDEDDEAYGKPVKY DPSFRGPIKN---------------------------------------------------RSCTDVICCVLFLLFILGY IVVG--IVAWLYGDPRQVLYPRNSTGAYCG-----------MGE--NKDKPYLLYFNIFSCILSSNIISVAENG------ ---LQCPT-P-------------------------------QVCVSSCPEDPWT---VGKNEFS----QTVGEVFYTKNR NFCLPGVPWN----MTVITSLQQELCPSFLLPSA------PALGRCFPWTNV---------------------------- --------------------------TPPALP---------GITNDTTIQQGISG-----------------LIDSLNAR DISVKIFEDFAQSWYWILVALGVALVLSLLFILLLR-LVAGPLVLVLILGVLGVLAY--------------------GIY YCW-EEYRVLRDKGA--SISQLGFTT---------NLSAYQSV-QET---WLAALIVLAVLEAILLLMLIFLRQRIRIAI ALLKEASK---AVGQMMSTMFYPLVTFVLLLICIAYWAMTALY--LATS-------------GQPQ-YVLWA-------- -------SNISSPGCEKVPINTSCN------PTAHLVNSSCPGLMCVFQGYSSKGLIQRSVFNLQIYG-VLGLFWTLNWV LALGQCVLAGAFASFYWAFHKPQDIPTFPLISAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGVQ---NPVA R-CIMC---CFK--CCLWC-LEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNIVR--VVVLDKVT---------- ---------------DLLLFFGKLLVVGGVG----VLSFFFFSGRIPGLGKDF-KSPHLNYYWLPIMTSILGAYVIASGF FSVFGMCVDTLFLCFLEDLERNNGSLDRPYYMSKSLLKILGKKNEAPPDNKKRKK------------------------- ----------------------------------------------------------- >Pan_troglodytes_SLC44A4 -------------------------------------------------------------------------------- -------------------------------------------------------------MGGKQRDEDDEAYGKPVKY DPSFRGPIKN---------------------------------------------------RSCTDVICCVLFLLFILGY IVVG--IVAWLYGDPRQVLYPRNSTGAYCG-----------MGE--NKDKPYLLYFNIFSCILSSNXXXXXXXX------ ---XXCSVCT-------------------------------QVCVSSCPEDPWT---VGKNEFS----QTVGEVFYTKNR NFCLPGVPWN----MTVITSLQRELCPSFLLPSA------PALGRCFPWTNV---------------------------- --------------------------TPPALP---------GITNDTTIQQGISG-----------------LIDSLNAR DISVKIFEDFAQSWYWILVALGVALVLSLLFILLLR-LVAGPLVLVLILGVLGVLAY--------------------GIY YCW-EEYRVLRDKGA--SISQLGFTT---------NLSAYQSV-QET---WLAALIVLAVLEAILLLVLIFLRQRIRIAI ALLKEASK---AVGQMMSTMFYPLVTFVLLLICIAYWAMTALY--LATS-------------GQPQ-YVLWA-------- -------SNISSPGCEKVPINTSCN------PTAQLVNSSCPGLMCVFQGYSSKGLIQRSVFNLQIYG-VLGLFWTLNWV LALGQCVLAGAFASFYWAFHKPQDIPTFPLISAFICTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGVQ---NPVA R-CIMC---CFK--CCLWC-LEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNIVR--VVVLDKVT---------- ---------------DLLLFFGKLLVVGGVG----VLSFFFFSGRIPGLGKDF-KSPHLNYYWLPIMTSILGAYVIASGF FSVFGMCVDTLFLCFLEDLERNNGSLDRPYYMSKSLLKILGKKNEAPPDNKKRKK------------------------- ----------------------------------------------------------- >Macaca_mulatta_SLC44A4 -------------------------------------------------------------------------------- --------------------------------------------------------------GPFRRNKDDEAYGKPVKY DPSFRGPIKN---------------------------------------------------RSCTDVICCVLFLLFILGY IVVG--IVAWLYGDPRQVLYPRNSTGAYCG-----------MGE--NKDKPYLLYFNIFSCILSTNIISVAENG------ ---LQCPT-P-------------------------------QVCVSSCPEAPWT---VGKNQFS----QTVGEVFYTKNR NFCLPGVPWN----MMVITSLQQELCPSFLLPSA------PALGRCFPWTNV---------------------------- --------------------------TLPELP---------GITNDTTIAQGISG-----------------LIDSLNAR DISVKIFEDFAHSWYWILVALGVALLLSLLFILLLR-LVAGPLVLVLILGVLGVLAY--------------------GIY YCW-EEYRVLRDKGA--SISQLGFTT---------NLSAYQSV-QET---WLAALIVLAVLEAILLLVLIFLRQRIRIAI ALLKEASK---AVGQMMSTMFYPLVTFVLLLICIAYWAMTALT--VPEQ-------------RQPQ-YVLWA-------- -------SNISSPGCEKVSINTSCN------PMDQPVNSSCPGLMCVFQGYSSKGLVQRSLFNLQIYG-VLGLFWTLNWV LALGQCVLAGAFASFYWAFHKPQDIPTFPLISAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGVQ---NPVA R-CIMC---CFK--CCLWC-LEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFTLLMRNIVR--VVVLDKVT---------- ---------------DLLLFFGKLLVVGGVG----VLSFFFFSGRIQGLGRDF-KSPHLNYYWLPIMTSIMGAYVIASGF FSVFGMCVDTLFLCFLEDLERNDGSLDRPYYMSKSLLKILGKKNEAPPDNKKRKK------------------------- ----------------------------------------------------------- >Mus_musculus_SLC44A4 -------------------------------------------------------------------------------- -------------------------------------------------------------MGRK--QNENEAHGNSAKY DPSFRGPIKN---------------------------------------------------RGCTDIICCVLFLIFILGY IIVG--LVAWVYGDPRQVLYPRNSTGAYCG-----------VGD--NKDKPYVLYFDILSCAAAINIISIAENG------ ---LQCPT-P-------------------------------QVCVSSCPLAPWA---VEVFQFS----KTVGEVYG-ERR NFCLPAVSPD----MIVEESLQKGLCPRFLLPST------PALGRCFPLPNIN--------------------------- -------------------------FTLPEDL---------RINNTT-VSNGISG-----------------LLDSINAR DVSVKIFEDFAQSWYWILVALGVALALSLLFILLLR-LVAAPLVLLLIVGVLAVLAY--------------------GIY HCW-QQYQVFRDKGA--SITQLGFTT---------NFSAYQSV-KET---WLAALIVLAVLEGILLLMLIFLRQRIRIAI ALLKEASR---AVGQMMSTMFYPLVTFVLLVICIGYWAVTALY--LATS-------------GQPQ-YIYWA-------- -------SNTSTPGCENVPVNMTCD------PMAP-LNSSCPNLKCVFKGYSTTGLAQRSLFNLQIYG-VLGLFWTVNWV LALGQCVLAGAFASFYWAFHKPRDIPTFPLSSAFIRTLRYHTGSLAFGALILSLVQIARVILEYIDHKLRGSQ---NPVA R-CIIC---CFK--CCLWC-LEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNVLR--VVVLDKVT---------- ---------------DLLLFFGKLLVVGGVG----VLSFFFFSGRIKGLGKDF-ENPNLNYYWLPIMTSIMGAYVIASGF FSVFGMCVDTLFLCFLEDLERNDGSQERPYYMPKALLKILGKKNEAPTGGKTRKK------------------------- ----------------------------------------------------------- >Rattus_norvegicus_SLC44A4 -------------------------------------------------------------------------------- -------------------------------------------------------------MGKK--QKENEAYGNSAKY DPSFRGPIKN---------------------------------------------------RGCTDIICCVLFLVFILGY IVVG--LVAWVYGDPRQVLYPRNSTGAYCG-----------VGD--NKDKPYVLYFNILSCAAAINVISIAENG------ ---LQCPT-P-------------------------------QVCVSSCPQTPWV---VEGFQLS----NTVGDVYK-EYR NFCVPAVSPD----MVVMDSLQKGLCPSFLLPST------PALGRCFPLPNIN--------------------------- -------------------------FTLPEQL---------QINNTT-VSKGISG-----------------LLDSINAR DVSVKIFEDFAQSWYWILVALGVALVLSLLFILLLR-LVAAPLVLLLIVGVLAVLAY--------------------GIY HCW-QQYRELRDQGV--SITQLGFTA---------NLSAYQNV-KET---WLAALIILAVLEGVLLLMLIFLRQRIRIAI ALLKEASR---AVGQMMSTMFYPLVTFVLLVICIGYWAVTALY--LATS-------------GQPQ-YVYWV-------- -------HNTSTPGCEKVLVNVSCD------PMAP-LNSSCPELKCTFTGYSSSGLAQRSLFNLQIYG-ILGLFWTVNWV LALGQCVLAGAFASFYWAFHKPRDIPTFPLSSAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGSQ---NPVA R-CIIC---CFK--CCLWC-LEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNVVR--VVVLDKVT---------- ---------------DLLLFFGKLLVVGGVG----VLSFFFFSGRIKGLGKDF-KNPDLNYYWLPIMTSIMGAYVIASGF FSVFGMCVDTLFLCFLEDLERNDGSQERPYYMPKALLKILGKKNEVPTGGKNRKK------------------------- ----------------------------------------------------------- >Canis_familiaris_SLC44A4 -------------------------------------------------------------------------------- -------------------------------------------------------------MGGK--QDRNEAYGKPAKY DPSFRGPIRN---------------------------------------------------RSCTDVICCVLFLLFILGY IVVG--IVAWVYGDPRQVLYPRNSTGAYCG-----------VGA--NKDKPYLLYFNIFSCVLTANVITVAENG------ ---LQCPT-P-------------------------------QVCVSSCPENAWT---VEVNQLS----EKVGEVFYTANR NFCLPGVPWD----MPVIQSLQQELCPGFLLPST------PALGRCVPFLNS---------------------------- --------------------------TPPELP---------GISSNTSISQGISG-----------------LFDILNAR DISVKIFEDFAQSWYWILTALGVALVLSLLFILLLR-LVAGPLVLVLILGVLGVLAY--------------------GIY HCW-EEYRVLRDEGA--SITQLGITT---------NLSAYRNV-QET---WLAALIVLAVLEGILLLMLIFLRQRIRIAI ALLEEASK---AVGHMMSTLFYPLVTFVLLLICIVYWAMTALY--LATS-------------GQPQ-YVLWA-------- -------PNASLPSCGKVQMNTSCN------PMAQPVNSSCPGLRCIFQSYSSTGLVQRSLFNLQIYV-VLALFWTVNWV LALGQCVLAGAFASFYWAFQKPQDIPTFPLSSAFIRTLRYHTGSLAFGALILTLVQMARVILEYIDNKLRGSQ---NPMA R-CIMC---CFK--CCLWC-LEKFIKFLNRNAYIMIAVYGKNFCVSAKNAFMLLMRNIVR--VVVLDKVT---------- ---------------DLLLLFGKLLVVGGVG----VLSFFFFTGRIQGLGRHF-ENPALNYYWLPIMVSILGAYVIASGF FSVFGMCVDTLFLCFLEDLERNDGSADRPYYMSKTLLKILSKKNEALPGHKKRKK------------------------- ----------------------------------------------------------- >Equus_caballus_SLC44A4 -------------------------------------------------------------------------------- -------------------------------------------------------------MGGKKDGDGDEAYGKPVKY DPSFRGPIKN---------------------------------------------------R