>Homo_sapiens_PRRC2A MSDRSGPTAKGKDGK-KYSSLNLFDTYK-----GKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPK-RPPAAPENTPLVPSGVKSWAQASVTHGA HGDG--GRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQ-NSTTWRDGGGR------GPD-ELEGP DSKLHHGH------------------------------------------------------DPRGGLQPSG-------- -PPQFPPYRGMMPPF----MYPPYLPFPPPYGPQGPYRYPTP-DGP--SRFPR-----------VAGPRGSGPPM----- ---RLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHR------------D SQSASGEERPPEADGKKGNSP------NSEPPTPKTAWAE---------------------------------------- ------TSRPPE--TEP-GPPAPKPPLPP-PHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAW-----RQRRKQSSSE ISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPP--------------------------- ---------AAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGG-STSSTSSG SFEASPVEPQLPSKEGP----------EPPEEVPPP---TTPPVPKVEPKGDGIGPTRQPP--------SQGLGYPKYQK SLPPRFQRQQQEQLLKQQQQ----HQWQQHQQGSA-PPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPP MNFDPRWMMIPPYVDPRLLQGRPP-LDFYPP--GVHPSGLVPRERSDSGGSSSEPFDR--HAPAMLRERGTPPVDPKLAW VGDVFTATP--AEPRPLTSPLRQ---------------------------AADEDDKGMRSETPPVPP-------PPPYL ASYPGFPENGAPGPPISRFPLEE---PGPRPLPWPPG--SDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGG QGPPPPRRESRTETRWG---------PRPGS--------------------SRRGIPPEEPGA--------PPRRAGPIK KPP-----------------------------------------------------------------PPTKVEELPP-- -----------------------KPLEQGDETPKPPKPDPLKITKGKLGGPKETPP------------------------ ----------------NGNLSPAPRLRRDYSYERVGPTS-------CRGRGRGEYFARGR---GFRGTYGGRGRGAR--S REFR-SYRE---FRGDDGRGGGTG---GPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHES--------- ---DLAPSDKEAP--TPKEGTLTQVPLAPPPPGAPPSPAPARF-----------TARGGRVFTPRGVPSRRGRGGGRPPP QVCPGWSPPAKSLAPKKP---PTGPLPPSKEPLKEKLIPG-----------PLSPVARGGSNGGSNV--GMEDGERPRRR RHGRAQQQDKPPRFRRLKQERENAAR---GSEGKPS-LTLPASAPGPEEALTTVTV------------------------ -------APAPRRAAAKSPDLSNQNS-DQANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTP--GGGGGGAVPGI SAMSRGDLSQRAKDLS---KRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRP PEERPP--GLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQAPQGPSPRPPTRYEP QRVN---SGLSSDPHFEEPGPMVRGVGGTPRDSA--GVSPFPPKR----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RERPPRKPELLQEESLPPPHSSGFL GSKPEGPGPQAESRDTGTEALTPHIWNRLH-------------------------------------------------- ------------------------------------------------------------------------------TA TSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPG--GSSPLNA VPCEGPPGSEP---PRRPPPAPHDGDRKELPREQPLPP-------GPIGTERSQRTDRGTEPGP---------------- -------------IRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKELTASVTEAIP-VSRDWELLPSAAASAEPQS-- K------NLDSGHCVPEPSSSGQ--RLYPEVFYGSAGPSSSQ-ISGGA-MDSQLHPNSGG-------------FRPGTPS LHPYRSQPLYLPPGPAPPSALLSG-------------------------------------------------------- ------------------LALKGQFLDFSTMQATELGKLPAGGVLYPPP-----SFLYSPAFCPSPL-PDT--------- ------------------------SLLQVRQDLPSPSDFYSTPLQPGGQSGFLP------SGAPAQQMLLPMVDSQ---L PVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPAS------------------------ -------------------------LGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFSG------LNSRLKAT PSTYS--GVFRTQR--VDLYQQASPPDALRWIPKPWERTGPPPREGPSRRAE-EPGSRGDK-EPGLPPPR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Pan_troglodytes_PRRC2A MSDRSGPTAKGKDGK-KYSSLNLFDTYK-----GKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQLK-RPPAAPENTPLVPSGVKSWAQASVTHGA HGDG--GRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQ-NSATWRDGGGR------GPD-ELEGP DSKLHHGH------------------------------------------------------DPRGGLQPSG-------- -PPQFPPYRGMMPPF----MYPPYLPFPPPYGPQGPYRYPTP-DGP--SRFPR-----------VAGPRGSGPPM----- ---RLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHK------------D SQSASGEERPPEADGKKSNSP------NSEPPTPKTAWAE---------------------------------------- ------TSRPPE--TEP-GPPAPKPPLPP-PHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAW-----RQRRKQSSSE ISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPP--------------------------- ---------AAPSTPAPPPAVPKELPAPPAPPPASAPTPEKEPEEPAQAPPAQSTPTPGVAAAPTLVSGGG-STSSTSSG SFEASPVEPQLPSKEGP----------EPPEEVPPP---TTPPVPKVEPKGDGIGPTRQPP--------SQGLGYPKYQK SLPPRFQRQQQEQLLKQQQQ----HQWQQHQQGSA-PPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPP MNFDPRWMMIPPYVDPRLLQGRPP-LDFYPP--GVHPSGLVPRERSDSGGSSSEPFDR--HAPAMLRERGTPPVDPKLAW VGDVFTATP--ADPRPLTSPLRQ---------------------------AADEDDKGMRSETPPVPP-------PPPYL ASYPGFPENGAPGPPISRFPLEE---PGPHPLPWPPG--SDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGG QGPPPPRRESRTETRWG---------PRPGS--------------------SRRGIPPEEPGA--------PPRRAGPIK KPP-----------------------------------------------------------------PPTKVEELPP-- -----------------------KPLEQGDETPKAPKPDPLKITKGKLGGPKETPP------------------------ ----------------NGNLSPAPRLRRDYSYERVGPTS-------CRGRGRGEYFARGR---GFRGTYGGRGRGAR--S REFR-SYRE---FRGDDGRGGGTG---GPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHES--------- ---DLAPSDKEAP--TPKEGTLTQVPLAPPPPGAPPSPAPARF-----------TARGGRVFTPRGVPSRRGRGGGRPPP QVCPGWSPPAKSLAPKKP---PTGPLPPSKEPLKEKLIPG-----------PLSPVARGGSSGGSNV--GMEDGERPRRR RHGRAQQQDKPPRFRRLKQERENAAR---GSEGKPS-LTLPASAPGPEEALTTVTV------------------------ -------APAPRRAAAKSPDLSNQNS-DQANEEWETASESSDFASERRGDKEAPPPVLLTPKAMGTP--GGGGGGAVPGI SAMSRGDLSQRAKDLS---KRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRP PEERPP--GLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGPPQAPQGPSPRPPTRYEP QRVN---SGLSSDPHFEEPGPMVRGVGGTPRDSA--GVSPFPPKR----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RERPPRKPELLQEESLPPPHSSGFL GSKPEGPGPQAESRDTGTEALTPHIWNRLH-------------------------------------------------- ------------------------------------------------------------------------------TA TSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPG--GSSPLNA VPCEGPPGSEP---PRRPPPAPNDGDRKELPQEQPLPP-------GPIGTERSQRTDRGTEPGP---------------- -------------IRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKELTASVTEAIP-VSRDWELLPSAAASAEPQS-- K------NLGSGHCGPEPSSSGQ--RLYPEVFYGSAGPSSSQ-ISGGA-MDSQLHPNSGG-------------FRPGTPS LHPYRSQPLYLPPGPAPPSALLSG-------------------------------------------------------- ------------------VALKGQFLDFSTLQATELGKLPAGGVLYPPP-----SFLYSPAFCPSPL-PDT--------- ------------------------SLLQVRQDLPSPSDFYSTPLQPGGQSGFLP------SGAPAQQMLLPMVDSQ---L PVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPAS------------------------ -------------------------LGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPAGRSFSG------LNSRLKAT PSTYS--GVFRTQR--VDLYQQASPPDALRWIPKPWERTGPPPREGPSRRAE-EPGSRGDK-EPGLPPPR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Macaca_mulatta_PRRC2A MSDRSGPTAKGKDGK-KYSSLNLFDTYK-----GKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPK-RPPAAPENTPLVPSGVKSWAQASVTHGA HGDG--GRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQ-NSTTWRDGGGR------GPD-ELEGP DSKLHHGH------------------------------------------------------DPRGALQPSG-------- -PPQFPPYRGMMPPF----MYPPYLPFPPPYGPQGPYRYPTP-DGP--SRFPR-----------VAGPRGSGPPM----- ---RLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHK------------D SQSASGEERPTEADGKKGNSP------NSELPPPKTAWAE---------------------------------------- ------TSRPPE--TEP-GPPAPKPPLPP-PHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAW-----RQRRKQSSSE ISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPP--------------------------- ---------AAPSTPAPPPAVPKELPAPLAPSPASAPTPEKEPEESAQAPPAQCTPTPGVAAAPTLVSGGG-STSSTSSG SFEASPVEPQLPSKEGP----------EPPEEVPPP---TTPPAPKVEPKGDGIGPTRQPP--------SQGLGYPKYQK SLPPRFQRQQQEQLLKQQQQ----QQWQQHQQGSA-PPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPP MNFDPRWMMIPPYVDPRLLQGRPP-LDFYPP--GVHPSGLVPRERSDSGGSSSEPFDR--HAPAMLRERGTPPVDPKLAW VGDVFTATP--TDPRPLTSPLRQ---------------------------AADEDDKGMRSETPPVPP-------PPPYL ASYPGFPENGAPGPPVSRFPLEEPAPPGPRPLPWPPG--SDEGAKIQTQPPKKEPPKEETAQLTGPEAGRKPARGVGSGG QGPPPPRRESRTETRWG---------PRPGS--------------------SRRGIPPEEPGA--------PPRRAGPIK KPP-----------------------------------------------------------------PPTKVEELPP-- -----------------------KPLEQGDETPKAPKPDPLKIAKGKLGGPKETPP------------------------ ----------------NGNLSPAPRLRRDYSYERVGPTS-------CRGRGRGEYFARGR---GFRGTYGGRGRGAR--S REFR-SYRE---FRGDDGRGGGTG---GPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHES--------- ---DLAPSDKEAP--PPKEGTLTQVPLAPPPPGAPPSPAPARF-----------TARGGRVFTPRGVPSRRGRGGGRPPP QVCPGWSPPAKSLAPKKP---PTGPLPPSKEPLKEKLIPG-----------PLSPVARGGSSGGSNV--GMEDGERPRRR RHGRAQQQDKPPRFRRLKQERENAAR---GSEGKPS-LTLPASTPGPEEALTTVTV------------------------ -------APPPRRAAAKSPDLSNQNS-DQANEEWETASESSDFASERRGDKEAPPPALLTPKAVGTP--GGGGSGAVPGI SAMSRGDLSQRAKDLS---KRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGAGPGGRTGPGRGDKRSWPSPKNRSRP PEERPP--GLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGPPQTPQGPSPRPPTRYEP QRVN---NGLSSDPHFEEPGPMVRGVGGTPRDSA--RVSPFPAKR----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RERPPRKPELLQEESCTP-HSSGFL GSK-LGPGPQAESRDTGTE-LTPHIWNRLH-------------------------------------------------- ------------------------------------------------------------------------------TA TSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPG--GPSPLNA VPCEGPPGSEP---PRRPPPAPHDGDRKELPREQPLPP-------GPIGTERSQRTDRGTEPGP---------------- -------------IRPSHLPGPPVQFDTSDKDSDLRLVVGDSLKAEKELTASVTEAIP-VSRDWELLPSAAASAEPQS-- K------NLGSGHCGPEPPSSGQ--RLYPEVFYGSAGPSSSQ-ISGGA-MDSQLHPNSGG-------------FRPGTPS LHPYRSQPLYLPPGPAPPSALLSG-------------------------------------------------------- ------------------VALKGQFLDFSTLQAAELGKLPAGGVLYPPP-----SFLYSPAFCPSPL-PDT--------- ------------------------SLLQVRQDLPSPSDFYSTPLQPGGQSGFLP------SGAPAQQMLLPMVDSQ---L PVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPAS------------------------ -------------------------LGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFSG------LNSRLKAP PSTYS--GVFRTQR--IDLYQQASPPDALRWIPKPWERTGPPSREGPSRRAE-EPGSRGDK-EPGLPPPR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Mus_musculus_PRRC2A MSDRSGPTAKGKDGK-KYSSLNLFDTYK-----GKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPK-RPPTAPENTPSVPSGVKSWAQASVTHGA HGDG--GRASNLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQ-NSTTWRDGGGR------GPD-DLEGP DSKLHHGH------------------------------------------------------DPRGGLQPSG-------- -PPQFPPYRGMMPPF----MYPPYLPFPPPYGPQGPYRYPTP-DGP--SRFPR-----------VAGPRGSGPPM----- ---RLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHK------------D SQSAAAEE--PETDGKKGTSP------GSELPPPKTAWTE---------------------------------------- ------NARPSE--TEP-APPTPKPPPPP-PHRGPVGNWGPPGDYPDRGGPPCKPPAPEDEDEAW-----RQRRKQSSSE ISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPP--------------------------- ---------VTPAAPALPPVVPKEIPAAPALPPTPTPTPEKEPEEPAQAPPVQAAPSPGVAPVPTLVSGGGCTANSNSSG SFEASPVEPQLPSKEGP----------EPPEEVPPP---TTPPAPKMEPKGDGVGSTRQPP--------SQGLGYPKYQK SLPPRFQRQQQEQLLKQQQQQ--Q-QWQQQQQGTA-PPAPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPP MNFDPRWMMIPPYVDPRLLQGRPP-LDFYPP--GVHPSGLVPRERSDSGGSSSEPFER--HAPPLLRERGTPPVDPKLAW VGDVFTTTP--TDPRPLTSPLRQ---------------------------AADEEEKSMRSETPPVPP-------PPPYL ANYPGFPENGTPGPPISRFPLEESAPPGPRPLPWPPG--NDEAAKMQAPPPKKEPSKEEPPQLSGPEAGRKPAR----GG QGPPPPRRENRTETRWG---------PRPGS--------------------CRRGIPPEEPGV--------PPRRAGPIK KPP-----------------------------------------------------------------PPVKVEELPP-- -----------------------KSLEQGDETPKVPKPDALKTAKGKVG-PKETPP------------------------ ----------------GGNLSPAPRLRRDYSYERVGPTS-------CRGRGRGEYFARGR---GFRGTYGGRGRGAR--S REFR-SYRE---FRGDDGRGGGSG---GTNHPSAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHES--------- ---DLAPSDKEAP--PPKEGVLGQVPLAPPQPGAPPSPAPARFS----------TARGGRVFTPRGVPSRRGRGGGRPPP -VCSGWSPPAKSLVPKKP---PTGPLPPSKEPLKEKLISG-----------PLSPMSRAGNMG-----VGMEDGERPRRR RHGRAQQQDKPPRFRRLKQERENAAR---GADGKPPSLTLAASTPGPEETLTAATV------------------------ -------PPPPRRTAAKSPDLSNQNS-DQANEEWETASESSDFASERRGDKETPPAALMTSKAVGTP--GANAGGAGPGI SAMSRGDLSQRAKDLS---KRSFSSQRPGMDRQNRRPGTGGKTGSGGGSSGGGGAGPGGRTGPGRGDKRSWPSPKNRSRP PEERPP--GLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGNVTAPGGHPRPKPGPPQAPQGSSPRPPTRYDP PRASS---AISSDPHFEEPGPMVRGVGGTPRDSA--GVNPFPPKR----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RERPPRKPELLQEETVPASHSSGFL GSKPEVPGPQEESRDSGTEALTPHIWNRLH-------------------------------------------------- ------------------------------------------------------------------------------TA TSRKSYQPGSIEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGSAEGPPKRPG--GPSPLNA VPGESASGSEPSEPPRRRPPASHEGERKELPREQPLPP-------GPIGTERSQRTDRGPEPGP---------------- -------------LRPAHRPGSQVEFGTTNKDSDLCLVVGDTLKGEKELVASATEAVP-ISRDWELLPSASTSAEPQP-- K------SLGSGQCVPEPSPSGQ--RPYPEVFYGSPGPPNSQQVSGGAPIDSQLHPNSGG-------------FRPGTPS LHQYRSQPLYLPPGPAPPSALLSG-------------------------------------------------------- ------------------VALKGQFLDFSALQATELGKLPAGGVLYPPP-----SFLYSAAFCPSPL-PDP--------- ------------------------PLLQVRQDLPSPSDFYSTPLQPGGQSGFLP------SGAPAQQMLLPVVDSQ---L PVVNFGSLPPAPPPAPPPLSLLPVGPALQPPNLAVRPPPAPAARVLPSPARPFAPS------------------------ -------------------------LGRAELHPVELKPFQDYRKLSSNLGGPGSSRTPPSGRPFSG------LNSRLKAP PSTYS--GVFRTQR--IDLYQQASPPDALRWMPKPWERAGPPSREGPPRRAE-EPGSRGEK-EPGLPPPR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Rattus_norvegicus_PRRC2A MSDRSGPTAKGKDGK-KYSSLNLFDTYK-----GKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPK-RPPTAPENTPSVPSGVKSWAQASVTHGA HGDG--GRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQ-NSTTWRDGGGR------GPD-ELEGP DSKLHHGH------------------------------------------------------DPRGGLQPSG-------- -PPQFPPYRGMMPPF----MYPPYLPFPPPYGPQGPYRYPTP-DGP--SRFPR-----------VAGPRGSGPPM----- ---RLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHK------------D SQSAAGEE--PETDGKKGTSP------GSELPPPKTAWTE---------------------------------------- ------NSRPSE--TEPAAPPIPKPPPPP-PHRGPVGNWGPPGDYPDRGGPPCKPPAPEDEDEAW-----RQRRKQSSSE ISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPP--------------------------- ---------VTPPAPALPPVVPKETPTPPALPPTPTPTPEKDPEEPAHAPPVQSAPTQAGPPAPTPVSGGG-TASSTSSG SFEASPAEPQLPSKEGP----------EPPEEVPAP---TTPPAPKVEPKGDGVGPTRQPP--------SQGLGYPKYQK SLPPRFQRQQQEQLLKQQQQQ--QWQQQQQQQGTA-PPAPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPP MNFDPRWMMIPPYVDPRLLQGRPP-LDFYPP--GVHPSGLVPRERSDSGGSSSEPFER--HAPPLLRERGTPPVDPKLAW VGDVFTTTP--TDPRPLTSPLRQ---------------------------AADEEEKSLRSETPPVPP-------PPPYL ANYPGFPENGTPGPPISRFPLEESAPPGPRPLPWPPG--NDEAAKMQAPPPKKEPPKEEPAQLSGPEAGRKPARGVGGGG QGPPPPRRENRTETRWG---------PRPGS--------------------CRRGIPPEDPGV--------PPRRAGPIK KPP-----------------------------------------------------------------PPVKADELPP-- -----------------------KSLEPGDETPKAPKPDALKTAKGKVG-PKETPA------------------------ ----------------GGNLSPAPRLRRDYSYERVGPTS-------CRGRGRGEYFARGR---GFRGTYGGRGRGAR--S REFR-SYRE---FRGDDGRGGGSG---GTNHPSAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHES--------- ---DLAPSDKEAP--PPKEGVLAQVPLAPPQPGAPPSPAPARFS----------TARGGRVFTPRGVPSRRGRGGGRPPP -VCSGWSPPAKSLVPKKP---PTGPLPPNKEPLKEKLISG-----------PLSPMSRAGNMG-----VGMEDGERPRRR RHGRAQQQDKPPRFRRLKQDRENAAR---GTDGKPPPLTLPASTPAPTETLATVAA------------------------ -------PPPPRRTAAKSPDLSNQNS-DQANEEWETASESSDFASERRGDKETPPAALITSKAVGTP--GGNSGGAGPGI STMSRGDLSQRAKDLS---KRSFSSQRPGMDRQNRRPGAGGKTG-GGGSSGGGGAGPGGRTGPGRGDKRSWPSPKNRSRP PEERPP--GLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGNVTAPGGHPRPKPGPPQAPQGSSPRPPTHYDP PRASN---AISSDPHFEEPGPMVRGVGGTPRDSA--GVNPFPPKR----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RERPPRKPELLQEETVPASHSSGFL GSKPEVPGPQEESRDSGTEALTPHIWNRLH-------------------------------------------------- ------------------------------------------------------------------------------TA TSRKSYQPGSIEPWMEPLSPFEDVAGTEMSQSDSGVDLSGGSQVSSGPCSQRSSPDGGLKGSAEGPPRRPG--GPSPLKA VPGESSSASEPSEPHRRRPPASHEGERKELPREQPLPP-------GPIGTERSQRTDRGPEPGP---------------- -------------LRPAHRAGSQVEFGTTNKDSDLCLVVGDTLKGEKELAASATEAVP-VSRDWELLPSASASAEPQA-- K------SLGSGQCGPEPSPSGQ--RLYPEVFYGSPGPPNSQ-VSGGAPIDSQLHPSSGG-------------FRPGTPS VHQYRSQPLYLPPGPAPPSALLSG-------------------------------------------------------- ------------------VALKGQFLDFSALQATELGKLPAGGVLYPPP-----SFLYSAAFCPSPL-PDP--------- ------------------------PLLQVRQDLPSPSDFYSTPLQPGGQSGFLP------SGAPAQQMLLPVVDSQ---L PVVNFGSLPPAPPPAPPPLSLLPVGPALQPPNLAVRPPPAPAARVLPSPARPFPAS------------------------ -------------------------LGRAELHPVELKPFQDYRKLSSNLGGPGSSRAPPSGRSFSG------LNSRLKAP PSTYS--GVFRTQR--IDLYQQASPPDALRWMPKPWERTGPPSREGPPRRAE-EPGPRGEK-EPGLPPPR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Felis_catus_PRRC2A MSDRSGPTAKGKDGK-KYSSLNLFDTYK-----GKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQQK-RPPAAPENTPSVPSGVKSWAQASVTHGA HGDG--GRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQ-NSTTWRDGGGR------GPD-ELEGP DSKLHHSH------------------------------------------------------DPRGALQPSG-------- -PPQFPPYRGMMPPF----MYPPYLPFPPPYGPQGPYRYPTP-DGP--SRFPR-----------VAGPRGSGPPM----- ---RLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHK------------E SQSAAGEERPPEADGKKGNSP------GSEPPPPKTAWAE---------------------------------------- ------TSRPPE--TEP-GPPAPKPPPPP-PHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAW-----RQRRKQSSSE ISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAVPP--------------------------- ---------SAPPAPAPPPAVPKELSAPPVPPPAPAPTPEKEPEEPAQAPPAQSTPTTGVAPAPTLVSGGG-STSSTSSG SFEASPVEPQLSSKEGS----------EQPEEVPSP---ATTPAPKVEPKGDGVGPSRQPP--------SQGLGYPKYQK SLPPRFQRQQQEQLLKQQQQ----QQWQQHQQGSA-PPAPVPPSPPQPVTMGAVPAPQAPPPPPKALYPGALGRPPPMPP MNFDPRWMMIPPYVDPRLLQGRPP-LDFYPP--GVHPTGLVPRERSDSGGSSSEPFER--HAPPLLRDRGTPPVDPKLAW VGDVFTTTP--TDPRPLTSPLRQ---------------------------AADEDDKGMRSETPPVPP-------PPPYL ASYPGFPENGATGPPIPRFPLDEPAPAGPRPLPWPPG--NDEATKIQAPPPKKETPKEETPQLTGPEANRKPTRGVG--G QGPPPPRRESRTETRWG---------PRPGS--------------------SRRGIPPEEPGA--------PPRRAGPIK KPL-----------------------------------------------------------------PPTKAEELPP-- -----------------------KPLEQCDESPKVPKPDILKTAKGKIGVPKETPP------------------------ ----------------SGNLSPAPRLRRDYSYERVGPTS-------CRGRGRGEYFARGR---GFRGTYGGRGRGAR--S REFR-SYRE---FRGDDGRGGSAG---GPSHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHES--------- ---DLAPSDKEAP--PPKEGVLTQVPLAPPPSGAPPSPAPARFS----------TARGGRVFTPRGVPSRRGRGGGRPPP PICPGWSPPTKSLAPKKP---PTAPLPPSKEPLKEKLITG-----------PLSPIARGGSSGGSNVGMGVEDGERPRRR RHGRAQQQDKPPRFRRLKQERENAAR---GTEGKPSSLALPAPASGVEETLTTVSM------------------------ -------PPPPRRAAAKSPDLSNQNS-DQANEEWETASESSDFASERRGDKEAPPSALLAPKAVGTP--GGSGGGTGPGI STMSRGDLSQRAKDLS---KRSFSSQRPGMERQNRRPGPGSKAGSGGSSSGGGGG-PGGRTGPGRGDKRSWPSPKNRR-- PEERPP--GLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSAAAPGGHPRPKPGPPQTPQGPSPRPPTRYDP QRANN---SVGSDPHFEEPGLMVRGVGGTPRDSA--GVNPFPPKR----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RERPPRKPELLQEESLPQSHSSGFL GPKPEGPGPQGECREAGTEALTPHIWNRLH-------------------------------------------------- ------------------------------------------------------------------------------TA ASRKSYRPGSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPG--DPSPLNA VPGEGSPGSESSEPPRRRPPAPLDGDRKELPREQPLPP-------GPIGTERLQRSDRGPEPGS---------------- -------------LRPSHRSGPPVQFGTSDQDSDLRLVVGDSLKAEKELAS-VTEAIP-VSRDWELLPSASASAEPQS-- K------NLGPGHCGPEPSSSGQ--RLYPEVFYGSPGPPNSQ-VSGGA-IDSQLHPNNGG-------------FRPGTPS LHPYRSQPLYLPPGPAPPSALLSG-------------------------------------------------------- ------------------VAVKGQFLDFSALQATELGKLPAGGILYPPP-----SFLYSPAFCPSPL-PDPP-------- ------------------------LLQ-VRQDLPSPSDFYSTPLQPGGQSGFLP------SGAPAQQMLLPMVDSQ---L PVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPPS------------------------ -------------------------LGRAELHPVELKPFQDYRKLSSNLGGPGSSRTPPAGRSFSG------LNSRLKAP PSTYS--GVFRTQR--IDLYQQASPPDALRWMPKPWERTGPPSREGPSRRAE-EPGSRGDK-DPGLPPPR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Equus_caballus_PRRC2A MSDRSGPTAKGKDGK-KYSSLNLFDTYK-----GKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPK-RPPAAPENTPSVPSGVKSWAQASVTHGA HGDG--GRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQ-NSTTWRDGGGR------GPD-ELEGP DSKLHQGH------------------------------------------------------DPRGGLQPSG-------- -PPQFPPYRGMMPPF----MYPPYLPFPPPYGPQGPYRYPTP-DGP--SRFPR-----------VAGPRGSGPPM----- ---RLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHK------------E SQSAAGEERPPEADGKKGNSP------GSELPPPKTAWAE---------------------------------------- ------TSRPPE--TEP-GPPAPKPPPPP-PHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAW-----RQRRKQSSSE ISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPP--------------------------- ---------AAPPAPAPPPAVPKEQPTPPAPPPAPVPTPEKEPEEPAQAPPAHSTPTPGVATAPTLVSGGG-STSSTSSG SFEASPVEPQLPSKEGP----------ELPEEVPSP---ATPPAPKVEPKGDGVGSSRQPS--------SQGLGYPKYQK SLPPRFQRQQQEQLLKQQQQ----QQWQ-HQQGSA-PPAPVPPSPPQPVTMGAVPAPQAPPPPPKALYPGALGRPPPMPP MNFDPRWMMIPPYVDPRLLQGRPP-LDFYPP--GVHPSGLVPRERSDSGGSSSEPFER--HAPPLLRDRGTPPVDPKLAW VGDVFTTTS--ADPRPLTSPLRQ---------------------------SADEDDKGMRSETPPVPP-------PPPYL ASYPGFPENGAPGPPIPRFPLEETAPPGPRPLPWPPG--NDEAAKIQVPPPKKETPKEETPQLTGPEASRKPARGVG--G QGPPPPRRENRTETRWG---------PRPGS--------------------SRRGIPPEEPGA--------PPRRAGPIK KPP-----------------------------------------------------------------PPAKVEELPP-- -----------------------KPLEQGDETPKIPKPDPLKMAKGKIGGPKETPP------------------------ ----------------SGNLSPAPRLRRDYSYERVGPTS-------CRGRGRGEYFARGR---GFRGTYGGRGRGAR--S REFR-SYRE---FRGDDGRGAGAG---GPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHES--------- ---DLAPSDKEAP--PPKEGVLAQVPLAPPPSGTPSSPAPARFS----------TARGGRVFTPRGVPSRRGRGGGRPPP PICPGWSPPTKSLAPKKP---PAGPLPPNKEPLKEKLIPG-----------PLSPMARGSS----NIAMGVEDGERPRRR RHGRAQQQDKPPRFRRLRQERENAAR---GAEGKPSPLALPVSTPGPEEALTTVVV------------------------ -------PPPPRRAAAKSPDLSNQNS-DQANEEWETASESSDFASERRGDKEAPPPALLTPKAAGTP--GGSGGGAGPGI STISRGDLSQRAKDLS---KRSFSSQRPGMERQNRRPGPGSKAGSSGSSSGGGGG-PGGRTGPGRGDKRSWPSPKNRSRP PEERPP--GLPLHPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSAAAPGGHPRPKPGTPQTPQGPSPRPPARYDP QRANNN--DVNSDPHFQESGPMVRGVGETPRDTA--GVNPFPPKR----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RERPPRKPELLQEESLPPSHSSGFL GTKPEGPGPQGESRDAGTEALTPHIWNRIH-------------------------------------------------- ------------------------------------------------------------------------------TA TSRKSYRPGSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPG--GPSPLNA VPGEGPPGSEPSEPPRRRPPAPHDGDRK----EQPLPP-------GPIGTERLQRTDRGPEPAS---------------- -------------LRPSHRPCPQVQFGTSDKDSDLRLVVGDSLKAEKELTASVPEAIP-ISRDWELLPSASASAEPQS-- K------NLGSGHCGPEPSSSGQ--RLYPEVFYGSPGPPSSQ-VSGGA-IDSQLHPNNGG-------------FRPGTPS LHPYRSQPLYLPPGPAPPSALLSG-------------------------------------------------------- ------------------VAVKGQFLDFSALQATELGKLPAGGVLYPPP-----SFLYSPAFCPSPL-PDPP-------- ------------------------LLQ-VRQDLPSPSDFYSTPLQPGGQTGFLP------SGAPAQQMLLPMVDSQ---L PVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPPS------------------------ -------------------------LGRAELHPVELKPFQDYRKLSSNIGGPGSSRTPPAGRQEKG------MGLRFKEY PLESC--PFHLWPPSLTYCSTWPPHPNTLRWMP-LWERAGPPSRERAFRRAE-EPGSRGDK-EPGLPPPR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Myotis_lucifugus_PRRC2A MSDRSGPTAKGKDGK-KYSSLNLFDTYK-----GKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPK-RPPAAPENTPSVPSGVKSWAQTSVTHGA HGDG--GRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQ-NSTTWRDGGGR------GPD-ELEGL DSKLHHGH------------------------------------------------------DPRGGLQPSG-------- -PPQFPPYRGMMPPF----MYPPYLPFPPPYGPQGPYRYPTP-DGP--SRFPR-----------VVGPRGSGPPM----- ---RLMEPMGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHK------------E SQATAGEERPPEADGRKGNSA------GSEPPPPKTAWAE---------------------------------------- ------TTRPPE--TES-GPPAPKPPPPPAPHRGPTGNWGPPGDYPDRGGPPCKPPAPEDEDEAW-----RQRRKQSSSE ISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPP--------------------------- ---------AAPPAPAPPPAVPKELPTPSAPSPAPAPTPEKALEEPAQAPPAQATPTAGVAPSPVLVSGGG-STSSTSSG SFEASPVEPQLPSKEGP----------EPPEEVPSP---ATPPAPKVEPKGDGVGPTRQPP--------SQGLGYPKYQK SLPPRFQRQQQEQLLKQQQQ-----QWQQHQQGST-PPAPVPPSPPQPVTIGAVPAPQAPPP--KALYPGALGRPPPMPP MNFDPRWMMIPPYVDPRLLQGRPP-LDFYPP--GVHPSGLVPRERSDSGGSSSEPFER--HAGPLLRDRGTPPVDAKLAW VGDVFTTTP--ADPRPLTSPLRQ---------------------------AADEDDKGMRSETPPVPP-------PPPYL ASYPGFPENGAPGPPLPRFPPEEPTAPGPRPLPWPPG--NDEAAKIQASPPKKETPKEETPQLTGPEANRKPPRGVG--G QGPPPARRESRTETRWG---------PRPGS--------------------SRRGGPPEEPGA--------PPRRAGPIK KPP-----------------------------------------------------------------PPTKVQELPP-- -----------------------KPPEQGDETLKVPKPDPLKTAKGKMGGPKETPPP----------------------- ----------------SGNLSPAPRLRRDYSYERVGPTS-------CRGRGRGEYFARGR---GFRGTYGGRGRGGR--S REFR-SYRE---FRGDDGRAGGAG---GPSHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHES--------- ---DLAPSDKEAP--PPKEGVLTQVPLAPPPSGAP-SPAPARFS----------TARGGRVFTPRGVPSRRGRGGGRPPP PICPSWTPPAKSLAPKKP---PAGPLP-SKEPLKEKLIPG-----------PLSPMARGSSGAGSTLSMAVEDGERPRRR RHGRAQQQDKPPRFRRLKQERESAAR---GAEGRRSSPALPSSTPGPEEALSTVAV------------------------ -------PPPPRRAAAKSPDLSNQNS-DQANEEWETASESSDFASERRGDKEAPPPALLTPKMVGTP--GGGASGAGPGI TTMSRGDLSQRAKDLS---KRSFSSQRPGMERQNRRPGPSSKAGSGG---GGAGGGPGGRTGPGRGDKRSWPSPKNRSRP PEERPA--GLPLPPPPPSSSAVFRLDRVIHSNPAGIQQALAQLSSRQGSAAAPGGHPRPKPGPPLTPQGPSPRPPTLYDP QRDNDNGIGIGSDLHFEEPGPMVRGVGGTPQDAA--GVNPFPPKR----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RERPPRKPELLQEESLPP-HSSGFL GPKPEGPGPHRESRDAGTEALSPHIWNRLH-------------------------------------------------- ------------------------------------------------------------------------------TA TSRKSYQPGPMEPWMEPLSPFEDVAATEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPG--GPSPLNA VPGEGPPGSEPSEPPRRRPLAPPDGDRKELPREQPLPP-------GPIGTERLQRADRGPEPGS---------------- -------------LRPSRRPGPPGQFGASDKDSDLRLVVGDSLKAEKELTASVTEAVP-VSRDWELLPSASASTEPQPQP R------SLGPGHCGPEPSSAGQ--RLYPEIFYGSPGPPSSQ-VSGGA-IDSQLHPNSGG-------------FRSGTP- VHPYRSQPLYLPPGPAPPSALLSG-------------------------------------------------------- ------------------VAVKGQFLDFSALQAAELGKLPAG-VLYPPP-----SFLYSPAFCPSPL-PDP--------- ------------------------PLLQVRQDLPSPSDFYSTPLQPGGQSGFLP------SG-AAQQMLLPMMDSQ---L PVVNFGSLPPVPPPAPPPLSLLPVGPALQPPSLAVRPPPAP--RVLPSPARPFPPS------------------------ -------------------------LGRAELHPVELKPFQDYRKLSSNLGGPGSSCTLPAGRSFSG------LSSRLKAT PSTYS--GVFRTQH--IDLHQQASPPDALRWMPKPWERTGPPSREGSSRRAE-EPGSRGDK-EPRLPPPR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Anolis_carolinensis_PRRC2A MSDRLGQTAKGKDGK-KYSSLNLFDTYK-----GKSLEIQKPTVTPRHGLQSLGKVAIARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQPDPKSTDASTAQPPESQSPPASQTPASNPPK-RPPTAPENPPTVPSGVKSWAQASVTHGA QGDGQGGKGSSLLSRFSREEFPTLQAAGDQDKAGKEKDTTDASYGPGPNLRPQ-NATTWRDGGGR------GTDGELVPE DGRAGVG------------------------------------------------------------MQPNV-------- -PPQFPPYRGMMPPF----MYPPYLPFPPPYGPQGPYRYPTP-EAQS-PRFQR-----------LPGPRPSQPPP----- ---RTSEPVGRPPVLKQDDLKEFDELDQENDEGWAGAHEEVDYTEKLKFSDEEDGKESDEEATEIRD------------E ASGPEGQT--LGTDVKKAGTP------KEDQPLVKTAWAE---------------------------------------- ------NSHPPEGAKEP-PPPAVRPPPPPPPPPPNRGNWGQPNDFPDRP---LRPPPQEDEDEAW-----RQRRKQSSSE ISAAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGALDKRLKPEPPKEP--------------------------- --------------PAPPPAPTPVPPNPPAPPALPEEK--RENEEPVLTSKPRSIVG-GGGGGGSSSNGGNLDSASHVEP PLTAPPKEVPKLREEPP----------VLPVPAVPA---AAPIPVKVEPKGETILQTRQPPP-------AQTLGYSKYQK SLPPRFQRQQQQVQPSLASSA--QQQTASASLSTLGPSGSVHPQAGPPGTQQPPAPPPSQQAPPKGMYPGSIGRPPPMPQ MNFDPRWMMIPPYMDPRMMQGRPP-MDFFPP--GVHPSGLLPRERSDSGGSSSEQFDR--HPP-ILRERGTPPVDPKMAW AGDVFTNAPSNTDSRPQAAALRQ---------------------------QQEEEEKALRSETPPVRLRDAV--TPQPYM GNYQGFSENGSSAP-LHRFPVDEPPRPGP---PWQAN--IALAASAEVNRNVRPEPQIQPPRKSEEEPYTAASRG----- ----PRSGSAKTESRWG---------PRPGS--------------------SRR--TEEISGEK-------TPRRAGPIK KPL-----------------------------------------------------------------PPKEMKDESE-- -----------------------------EIRPAAKFKEVAEAASNKPEPPKESPN------------------------ ----------------PGKENKTNRRRRDGPFDRGGYAGR------GRARGRGEYFARGR---GFRGAYSGRGRGGRGRS REFR-SYREPF-YRLDDGPGKPPG------PGSNFRPRNTSETRSEGSEYEEIPKRRRQRGSETGSETHESAS------- ---DVAHSDKEVTKEPAPSQRNRGHPMTNTSAPSSLHPGLPRFADKMPPRLSDPGTRGGRVFTPRGVPSRRGRGGGRAPP ---GGWSPPSKPQPNKKPEKQQEAPLESSVTPEDSNVFQG-----------PPKQQPLGPNPDR-----GFDR--PPRRR RHGRSQQQDKPPRFRRLKQERENAARL-NGEQRAAQPFPPAASVPVPEE------------------------------- -------STSRRVAGSKSPDLSNQNS-DQANEEWETASESSDFTERRGGGEKEPAPGGPPPTAFLKG--GCSGAPSVGGR PSNNELSLAQR-KEMS---KRSFSSQRPGMDRQNRRSNPAPGGGGSG--RAGRGGSGSGRSG---GDKRSWPSPKNRSRN TDDHSP--GLSLPPAP-TTSTVYRLDRVIHSDPAGIQQALAELGSRHAKPASSPGPAQPPFLGPRNSN-SSSLPLGRFES RSSGS---TGQTNSCFLDKNQLLRSNSGPLKDSG--ALSSFPAKQ----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------RER-SRKQDLLQQESLAFPSGPGFS APKEEAPGEPRSRSVPVSEGIAPQIWNQLN-------------------------------------------------- ------------------------------------------------------------------------------SN SSRKSYRPASVEPWIDPLNAFEEVASTEMSLSDSGVDLSSDSQVSSATCSQRSSPDGGLKATPDTGNKHSGAIGTGSSDA TVATGPEGAEPKEQRRRPPPARDSSLLKEKVSGSPEPPPRDHPPPGAIGTERSQRAEKAKDGGE---------------- -------------GLGTMKSEAGAQFGASEKDADLRFIVNEGPKADKEALTEGLASAP---REWELLPPPPASHRASP-- E------MLPGRSCDSRPCERGQGQRLYPELFYGSQDPPHIQ-KSGQAPLESQLHGSSGAS----------SYHRPSTPS LHTYRSQHLYLQPSPGPTSALLSG-------------------------------------------------------- ------------------VALKGQYVEISALQAAELPKLPATGLLYQAPP---PSFIYSSAFCGSQLPPEQA-------- ------------------------MLQQMRQDLASPSEFYPATLGQGSQSNFLT------ATGPAQQVLLPVVEPPQL-P PVVNFGSLQQGPPAATAPPP--PPMPLVPMATQALRPPGQMPGRLMSPAVRAFPHGG----------------------- -------------------------VGRSELHTLEMKPLQDYRKLNG--LGAAGARPPSGGRPFSGG-----FNARLKSP ASGYG--SIFRAQR--FEVYQQALQS-DVRWSPRAWERAPQPRDGGPPRRLEPDPRSHSDKQDPSLSSHH---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Xenopus_tropicalis_PRRC2A MSERLGQTAKGKDGK-KYSSLNLFDTYK-----GKSLEVQKPAVTPRHGLQSLGKVVVARRMPPPANLPSLKAEN--KGN DPNVSLVPKDGSGWASKQDTQEPKSSDVSPPVQPESQLQPVMQTPASNQPK-HPPVSQEPPPPVAAVVKTWAQASVTHGS QGDG--GKASSQLSPFSREEFPTLQAAGDQDKSGHDLGTSAVSYGPGPSLRPQ-NATNWRDGGGRGGLAVSSLDGESREP PSDMGHPPS---------------------CE-----------------------------TASRPGLPQPT-------- -PQQFPQYRGMLAPF----MYPPYLPFPPPYGPQGAFRFHGA-DAP--SRFPR-----------LAAPRVPPAVT----- ---RMPEHLSRPSILKQDDLKEFDELDQETDDGWAGAHEEVDYSEKLKFSDDEDGKETDEEEKRETKGL--------NTD SSITPPKKVEDSSDVRKGAPA------EEKSPPAKVAWTE---------------------------------------- ------GSRGQE-------PVMTVTISATPLNRNQATHRGPQPEPKEKTVPQAVAPME-DEDEAW-----RQRRKQSSSE ISQAVERARRRREEEERRMEEERRAACAEKLKLLDMKCRPASEEVESAVSVKS--------------------------- ------------GGNDVEEPRSQTPPGLLRRPFLPDDPLAHTCISVVQEPPAQASISTFIFLKCLDLKGLG-FTQSTNES EMEASLSAVSIPDADAS----------PPVPEVPQVKRESVAQPSRPEIKQESAPPVSRPPPAG-----PSQSGYAKFQK ILPPRFQRQQQEQLMKQWQQ-----SREPTPSASVGPPTQQPSAPPQPPQKALYSGGSLGRTTPAPQPP---PAPLPSPH VSYDPRWVMVPHLIDPRLMQGRP--LDYYPPTAGVHPSGLMTRERSDSGGSGSDGYER--HPP-LMRERTTPPTDPKHLW GGEMFNAP----EARPLMSPMRQ---------------------------NIEDNDREIRSDTPPARAVASQNLQPPSYS GNFNAYPENEQRHPDSSTTPLSSPSAPSSQARRGNDETVILKREAAAAPPLSDAPTKEEITGMRHKEEKKEISKDEPKPD YHRPPSRRESKTETRWG---------PRPGV--------------------GGSRRQEETAATVGSQAQTSAQRRAGPIK RGVRREE-------------------------------------------------------------TVTQENKMSP-- -----------------------VPLAASETQKNKQVNHSEREAEETVGSPLRRRKE----------------------- ----------------IAGTIPPAR-------ESVALVPA------GRGRGRGEYFSRGR---GFRGAYSGRSRGGRGRS REFRGGYRKESPFYREDGYPEGKS-----SGRTDGRERNTSETRSEGSEYEEVPKRRRQRGSETGSETEPA--------- ------VSEKEVP----KSGQSQQQQKESSNSVSQRPPEKGKDS------------GRGRTFTPRGVPSRRGRGGTSMVT FSPHPKYQPPQPLLPPSQ----AAPQSHKPERKNEKVAFT-----------AIPSITTEERP----------QQPPRRRR HHGRSQQQDKPPRFRRLKQERENAARAGNAAGPQTPSQQILVAQELPQRSIQNEEE------------------------ -------RVVPRR-GLKSPEPCNANS-DQANEEWETASESSDFTEKKERGEMPVQNG---------------------GE SALSVNVTKDQKRDLS---KRSFSSQRPVMERQNRRPMHQSGQRTN-------RGGGTGRSG----DKRSWPSPRNKGGR SNEDRTSASLPLPQSTPTTNVVYRVDHVIHN-PVGIQQALSELGQRHSKRTNHNLDPSTGHVQPAAGKRSSDKSPNSHEP SQVSG---GAKHQKHLCRKDPLCSSCSKIPAETTSQAQEPTPPVQ----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------TEEPRDGPPSAETHAIQPQATVS-- ---NQEPPPWAVSLSTGIPKLAACYWGKEHP------------------------------------------------- ------------------------------------------------------------------------------TS TTKEPYLLSSMEPWMENINSYEDPINTEMSQSDSGVDLSSDSQLSSSNSSQRSSPDGGLK----------------PEDA KRSDQGRALEP---HHRGHSVKHNLQFSVLSTTVVVPSP------GPIGTERMQKPLADNSCGP---------------- -------------CSPSCIP--PVTCPPSPKVSKDLLSSR---KTEQQLCESDIHLIS--LRHWDTFPQARTPQQPALS- -------TVTPGGTRPAFPESQR---LYSNQFYQVTRPSASHYSMYQLDVDVHVSSAGSGY----------TGYRPGTPS LQPYRSQPLYLHAAPSPGSAVLSG-------------------------------------------------------- ------------------IALKGQYLEL-----SELGKVPSSGLLYQAP-----AFLYSGHYCPAQVTTDQQQ------- ------------------------QLLQVRQDMASPSDYYSPPIHHTGQNGYLP------P-APTQQVLLSLVDSQ---L PVMGFGSLSSAPQQP----SLVTLGQPIHPLS-ATGQTHSHNIRSEVSICRGYLTI------------------------ -------------------------LVQYQTHSADIKQSEDH---RMSVGVPGQCVSSADGRDYSPA-----IAKILMTK SSNYG----AVRNR--FDVYQQAHPSDASRWTARPWDRAPPLDADSKSTKSP---NSEGNP-TPN--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Danio_rerio_PRRC2A_a MSERSGQTAKGKDGKTKYASLNLFDTYK-----GKSLEAQKPVVAPRHGLQSLGKVASTRRMPPPANLPSLKAEN--KGN DPNVSLVPKDGTGWASKQEQADPKSTDVLSAAQPESQQPVASQTSAPSIPR-TPPAQEPPTPALAVGPRSWAPASVTHGA QGDG--GKGSNQPSPFSREEFPTLQAAGDQDRAGKEQATADQWYGPGPSLRPQ-NVTSWRDGGGRALAPTLAGEAVAEGG AGGVILMEG---------------------AAGAPPIQQQN-------ASSHGPPRTPPTSNPALPLPQPTI-------- -GPQFQAYRGIMPPF----MYPPYLPFPPPYGPQGPYRYPPPNEAPRFSRNQG-----------GIGPDGRPPGG----- ---PRGEVVKRPSILKQDDLKELDELDHDGDEGWAGAQEEIDYSAKLKFSDDEGEDDGEEERGENKNGTRESREQQRSQD GPVPVSRSRASDSGGDSRRTPPSSTEDGSVSPSSKPGWAEEGGSSWNSQANAGSYQGPRPGLGGTREQPSPPPGPLLGQG PHSYYRQDRPSN--QSPIPGPILAPQKPSSAHAQQQAGTVPGGPTPPPSNTLHPQQQGEDEDETW-----RQRRKQSSTE ISAAVERARRRREEEERRMQEERRAACAEKLKRLDEKQQQQTIKPSSPSDAPAN-------------------------- ------------------SPSPSLSAHASSPNVSQPSSPCVDTEEPPLLSAQGSGATLGLTNNNRQRAGSNSSHDSNNES QQVLQPQATQHPQSQDV----------PGPGDIKEEHVVGGPHIRSTRVGDDSVKVVECVGVTGRQGSGPSGQGFSKYQK SLPPRFQRQQQEQLLKQQQQ----WQQQQQQHNQVAAQNQLQSQPQNQQGPAPGTAPQSGPKQPTLYPPGSMGRPPPLP- MNFDPRWMMMP-YMDPRMMQGRPPPMDYYPP--SMHPSGMMNRERSDSGGSGSDPFDRQQHAGPPHSHRGTPPMDPKLAW GPDVFPGGT---EGRGLSSPLRQ---------------------------KAVEEEEAGKGQRSDTPP------------ VRMREGGTASVQQPGVAPSSPSGSSNQTPPPLGIQVG--GAGHHAHHQPFLDGRGGYSSYPDNGSRMGSHLQQRANSGGT LHGFGHQEGSQPNQIWGT--------PHPHY--------------------DRSDHSALESNS--------HHQHHGPPS HAP----------------------------------------------------------------------------- ------------------------------HFSLHPHKQENGREREKMVEPKKNDP------------------------ -----------------SPPLHQPSLSSSCSSSSSSSSAR------EDGSGKQSLHNQVP---PLHEHDTGSTHASG--- -------------RKQDKTGNAHN---QPPQHSGQQHHPRANPRNREHKTETHWGPRPGSSSVSGSSTHNR--------- --------------------KTGSGIIAITEPSGNQGAENKSFN------------------QSDGITVKRAG------- -------PIKRPVLKEIK-----------------------------------------------------REGGEGGGE KTTGGSGKDKEQDASQTTTKQEPATG-------------------------NQVIL------------------------ -------APSGKDDAVSSNKPRTGGK-ERGNTGGSGKGSKNGESSMQNS-----------------------------GY SASQSRREREHSPERG---STTYHSSSSRGSRSNRGRGEFYGRGRGYRGTYVGSAGGGNRGKAGGRNSRDYRPAANSGYH HPSSNQ----------------------------DYKREASSGSGRHGTSQPNPGRARNRSETRSEGSEYEEVPKRRRQR GSETGSESAGSDLAHSDKEDRKLNTKAGTVGENPTTGPSSSASVR----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NTQTRVFTPRGVPSRRGRGGGGAGG GLHRSGGGAGVSGGQRPGPGSSSHGWSAKSA------------------------------------------------- ------------------------------------------------------------------------------NV RKPQTSSQPPPAKDLSRGVNVDKKKPAEQNQPQSQSANPTTTVASVPTTIQQGSTENGNVGAPMSSTNAPS--------- ---------NPAGAPTQSLPLPAPDGRNFPNRGFERPP-----------RRRRHGRSQHQQDKP---------------- -------------PRFRRLKQERENAARINGSSGLIEVIAAQQQRTAPLLQNSLQQAN----STPNVPDAVVANANHSVS T------TPNSNNNSSNLAGGNQ--------NFNSHHHHHYQGNSQSHPQHHHNHNPAGG---------------AKSPD VSNQNSDQANEEWETASESSDFTE-------------------------------------------------------- ------------------FRER---------------EGGGGGKSYSSH------------------------------- ------------------------------------HHHHHHHHHPPGRGGGGG------GGGDREMTAKELASGK---- --------------------------------------------------RSFSSQ------------------------ ------------------------------------RPGMERQNRRVNAGGGGGGKGQRGPPGTGG-------------- ----------------------------------PVGGAGNGGGNRGERRGN-WPSPKNRK------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Drosophila_melanogaster_PRRC2A -MSTLGGSRGERNAKPKFTALDINRMYKNSRGESSEPSAQKNQVPRKHGMQILGKVPSARR--PPANLPSLKAET--HTS SNNNLLVSVEGATSGGAGAGGAAGSGAAGTNTSHNNTTAHSGSSGTSGGAGSGGGGTASSSAGGHLSQQLTHSQHQHNNN VALG--PNAGKFVNSNNGSSNNNAGSSGSGNKNFKLINNSVGSSGGGGQGGSGGGGSSGVGGGSGSGSGGHSVNSPKTWS AITTGHER------------------------------------------------------GSGGQNYGRQQ------- -QQVVPHYQSPQFQY----EFPTLDGTVGSGAGGGSGAGVGSGSGAGKSHYQN-------------QVHHAGHQN----- -----HHQHQQHHQQHQQHHHQQQQHHRDYHHGHGRQYGHHSHRDYRDGSDDVGGGSADLGELSLRPQN----------D TAAWLQQQEKAAKVAAAAAADQGLNLQGPGHHQMGGNGGAG--------------------------------------- ---------------GGSGGAVPLPILSLMPSFMRSGAPMPASGATAASILAGGSLDTSALPNAP-----YQNGILGARS ASPAVVGSGSFRAATAIPKRPPTSSSPPQSGLGIGGSPTPPQSQQQANGGAGGAGRKDKD-------------------- --------------YVVEPEVAQMQRPIIREEDLERLNAIAKDDSWTKQDDIDFTKKLAFSDDESTPEEHQGQGKQHSSA QLQAQGSSSSTDQRKLSASTTSWQRGKESTDRDQPSEGIQDQQQQLQQQQQQQEVRQQNGHRGSSGNVGAPVAGGIALDA SVYERVKQRKEEEERR--------EMERKQAAAKKLQELEMKMNSKKAAAAALAGAEGGVSSASVPLSNEVPPTSAPLGN ASEDEGGGQGGGGGLNRRPRGSISSLGSGVTPTGGAGGGGGGVSSSSSAGGDYGQKNFLTHFQSNLPPRFQRQQQQQQQQ LPRLEKSASASSAFDSNSRYLQK--------------------------GGVSGGGGGVSGGAQANAGQGRSISGGYVQR GASVGGSSGYGRNRHDSSSAREDQDLDQQRFTRGQDYRQAQALPRSISENSHRKTSVSSAGDDVLGGSCSSWAEQTDAEQ KVHHRHREESFSSSHSHDSAVQIKILQRPAR----------------------QPSLSEESSTQQKQLPASPQQQKTLTT DPMPTQILRRSVDID----------------------------------------------------KSGDERAEDKS-- ------------------------ALESDDKAKSAGKVEEDKSGNKRVSPRSGAACG----------------------- -----GRGGRGYAGSSGGSSVGSGSSYRGQRNASDWGSSRG-----SGGAGGRRYYGSGGE-QSEHSEDVDEECYSSGGG GAARRSPKESGNGAPNSGASANKAG----FSPRGEPSRRGRGGLSSGGGASASCYRRQPVGTGSAGGSGSGGSGRSYGRL GYEEYGKQQRTSESETDLDKTKQNQLALSAGLHKPSKDDKDLPALGGEEK------DKTAALAPAHNTALLAKDELQKDA AGRLPLPPGLAAPGSAVGSVTATSSSVVVPGAADKKKIES------------CAVVGGEKVTGSKLPAIGEKTSLGAVGS GPSTSLLLDAGAPVNTIIFENSTYKQQAAAASVVTKPGTLSVSSSGATMTVDSLSS------------------------ -------ALSQMSFGGKATAAGSGDDSQDMKLGFSFGDDPTTPLKVVDNIDKTASQQQQQQQQ--------QHSQQQQQQ QQQQNNSTADLNMKIAS-VKKVWESATPMSDGPSPAQVQQQQQQQPQQQQQSQVQVAAQQQQQQVVGPQQAGDDGSGHMS AASFVAAVAASQHQQQHQQMPHYAVSAVHMQSHHHQQQQQQQQAAVAAAQAQHHQQQQAQAHHQHHALSSPGPVPGSHGH GYSHGSPFDAGSLEQQFQQEDYPSPQQQQQAHQKTKQLQQQQHLG----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MSPPPSQQQQQQHSQQQQQAQHQQQQQ QAHQQQQQQQQPSFYQASPQFGVGGIPTIP-------------------------------------------------- -------------------------------------------------------------------------------S PPAVVYNSSQMPPPSQGGNLYAPFHSLDHSSRSPAYSAAAAAHSYPNPYAAAAAAAAAAAAGGGPFNVNVN--------- AYAMQTPHGGSLPPTAPTPDMYSNLSSQFRLGGGPGPGP------GPFGQPSSQQLSNPSNHAA---------------- ------------VAIISSSSNSMMSSGAAKPPQSQQTIGAIGSKSAGSGGGPGPGPGPYATTQTYMNLYAAPPPQHPGQG G-------PPPGAHQLQSNSFYSNSAPGGPSGPQFYGGPPPQGNGGAQSYGLATAAGMYGG-------------HQGGPP GSNGPPGPPQSQHTMGTFNTPFMN-------------------------------------------------------- -----------------------SQLLTAASINQYRGGPTPGAAYLKGNQGQTHMQDSMGRQLKSPLSADMSLG------ ----------------------LAKQVQSQPSPPHHKNYGAWDLQNQVLQQQQQQ-----SQQQQQQQQRQVGGGNGPSM NALGGRGSGAVGSGSGNGGGGGGGAGGSQVGGNGGGNGVGSVGQSGGGGQGRYPTP------------------------ ---------------------------IQRPNNYPQHPQQQQQQQQQQQQQREQAAAAAVAAQRAQN-------MRQVTG AGGGVAGSAGGGGSQTPVGPAGGNGGPGGAGGGGGAGGAAGSGPGKPYYANNASGAAVAANRGEWHAN------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Anopheles_gambiae_PRRC2A -MSTLGGSRGERNAKPKFAALDINKLYITSRGESFEPSTQKSTAPRKHGMQSLGKVPTARR--PPANLPSLKAEVGNPGE QSGSWTNELNEGQYVSQSPNHSTEEVNKIPNLSISKSSTQRHTSSPNISKP---------------GELSWNTSEFPSLD GTGS--YGGGTTKSQLFQEHYSG---TSQTNHQADIRSQLKAPCGQGTSIATEDLDGGGNFLGGLNSCQVTAGSSQSSPL PPQFRALLP--------------------------------------PFMQRGSESVLLGNENEGGSLSPIPSQTSIFST IPGMCNDSKNSSTAHNVTTNYNTDNRKMNSNGGNNCSSSSHKSNNNGEKISNVAVNTGTNVTIISSQFSKTQSSSLSTHS QQQQLNNRIGGGNSYSSIPSTRSGRVVRGGNGGSNNTSSEGGNDKTGGIAYDNSYQNANRRGGSNHLPR---------YA NRGTSGGGVGNYNNTIGNLRSNGGNVIGSGEVGSPSGFND---------------------------------------- --ENRNSHPPYGSSVLAEQEVVVRPIIRDEELQRLEAIAKDEGWAKDSEFDYNQKLEFSDDESELNQIPTAMKVKDMATD INIISVKAEKEQQEHEIFDKSDRTLDVSVAHRERDPNQDSMQINCSSGVRSLVGEGSAINVN------------------ -------MTAGGLDAAEAKERLKQRQEEDLKRDIERKLAAARKLQELEEKLSRKKTEESIDAKAGNNDISKSGNIASTIN ISTTLGNKLEEEKVFEPVSEHNNERVISVKIRGKSGERTNLKDARYEFGTGSRHDRETGNISGSTSSNWDMPGFSKTFQS NLPPRFQRRKLERNTSGAN----LLTSNNNSVGLVSPRIGNTGPCGSNSVGEIKSGIPFAQQYDPRFIHNQQTYGKNCNA MTSSSRRTAVSVRDRDERQRHHYDAVEHNQREVMKTKKESFEDGNRFNNATGGTQELNSYVNSKQNIGCVTPQLDRNLSE SSNRKTSVSSDDNHHTSQPHHKP---------------VIRNVGSNTKVSGNYVREKSWDMEDQKESSASSSASFSGSDV HRETPPRSDCDLPKQILHRVKETTPQSSSDSIKDEKMSFKQRIKKTVDCESNQNDEEIHRCEHLSFDGATIEDNSVGSSN TSLDPEDSSPGAAMDKASLLSRSDGYACFGIG---------------------ETNEKENVELNQLECPKDTTHETSHLS RSLGYTDDNKQITST---------------------------------------------TISHQPHQNSLKKKDATT-- ------------------------TQHSRDSRRHDSRSGVRGGGGYSVGFHRADGTGCMSSRGGSLNWNRPRGGSR--TG GAGRGYHQDCWSESEYSEESFDEQTKHHVHQKIYNHSMSVTVGI-HSTANADSTIFGGAKEGFVPRGEPSRRGRGGGNIG SIVSVVNPSSANNRQKQQGVFSGSITSIEESVAISKKVDGYGCTNSKNPFSSSTVDDDDRQTKHSVVDHSNSTVTSVISP IRDDRTVQHNKRPLSLCDAYNTSDDVLSLEKENPISKILEREHSAIDIRNDESHSREDSHKSDGRSNSTDHCLAVMKQTS DECDSNKSTAASLVDDTKTNTTKNGSTTTLQQQSTNLSTISG-----------SVGKLNNSMDSNVRGKAIVGNFRGGSI NVITLRQQQSVSQSQGGGKSSTTEGSSDSLVSVNTSNSNQLITTSNSNNDNDSMPSG----------------------- ------------TSGTRSSTLSVEGDIKCVTDQRHLTQQGVTEKLNASSTVSSNTDNDKHHLDGNNAPVNTTMIFDNTNF KSAVSALSVNNTNTVGDCGGTGVDASITNLKRQQSGNSVINVDAKVKSGLMNEKVITGASNAVGSIMKSPQSLTSNTSAH RPTTSIPVTTSSEGSSQHSIVGNSQRTVLSAGVTKQQSSTIITSTLQGIPFQKSETDYKEVKPFAFETDISHLIEGDKGI KQQSTVSAGLCLSKSIEVDGGNGHGRVSASVQNIISPSTADLNMK----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------IASVKKVWEMPTVPEQTGSGTVNSG GGGSATCNVNMANEHSVSGSGNVPSGNNVHLKSN---------------------------------------------- -----------------------------------------------------------------------------FVR TQHTSHQPQYQHSHAGTAGHHSHQAHGTHSSYGAAFGSESDSLVEHFNSSNNVCNIPNPTGSNNGCDINTG------ITL NNECNDPSNQGYGLSHHHSQQQPTKVHQQTHQLQQQHPHQ----QQDLHHQRQAHNMQESAQST---------------- ------------TQQHTQQPQKQLQHPSQHSLQHHSQQLQRQQQQHKEQSQHIQQLQQMHQQSQQQHKPQTQSQSQSHPP TQ-----PPSQSLPQSQAQTSQSQLKVQHSPQQQSQQIPQQLSQSQSQHSHSHQQHQPHKQ-----------SQIQQQLQ QHPAQQLPQQLQQTHHQQTLQLQH-------------------------------------------------------- ----------------QQQTQQTQHVSSVNVQQHQAAVAVTMGLNKHPVADVLAAAVAANNVNVCKVKPTQQS------- --------------------SAGGMHQSNSMGLSPPPQMQSGSIPSAPQPFYPAQYG----VSAVPSPPAVLYNSAAAAA AMNSQGGLYNAFQIEPSGRSQFSQFPGHYGTSGTTGGPYNTYMTPTATNMQTGPTPEMFQSLSSQFRMG----------- -----------------SVQSPYNQTTQMGNPNTMLISSNNTSLMSSSVKTSTQQIGAIGQPKPNGGGSVNQPPFGQQYL NMFPPAPLQNTAANYYSNSGGGQNAFFGAASATGAATQSAYGIPPAAVAASNMFGGHGGQNPSNTSQPPPPQQQMPNFSS QFLN---------------------------------------------------------------------------- -----------------------------------------SPLLAATNPTLGQQQYRGAPNNASQHSGANSSSYIKSNQ SPQSSHIQQQQQAQQQQDTVSYYSFYHK------- >Homo_sapiens_PRRC2B MSDRLGQITKGKDGKSKYSTLSLFDKYK-----GKSVDAIRSSVIPRHGLQSLGKVAAARRMPPPANLPSLKSEN--KGN DPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLNGKPVG HEGG--LRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKGVLDLSYGPGPSLRPQ-NVTSWREGGGRHIISATSLSTSPTEL GSRNS-------------------------STGDGAPSSAC------TSDSKDPSLRP-----AQPVRKGAS----QFMG NVYHPPTYHDMLPAF----MCSPKSSENQGTVERGSFPLPQLRLEPRVPFR-----QFQMNDQDGKENRLGLSRP---LR PLRQLVERAPRPTIINAENLKGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNS-----------W DPRRQRQLSMSSADSADAKRT-----REEGKDWAEAVGA----------------------------------------- ----------------SRVVRKAPDPQPPPRKLHGWAPGPDYQ-KSSMGSMFRQQSIEDKEDKPP-----PRQKFIQS-E MSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPWSPS-------------------- --------------------------------------------------------------AEKASPQENGPAVHKGSP EFPAQETPTTFPEEAPT------------------VSPAVAQSNSS---------EEEAREAGS------PAQEF-KYQK SLPPRFQRQQQQQQQ--------EQLYKMQHW-------------------------QPVYPPP--SHPQRTFYPHHPQM LGFDPRWMMMPSYMDPRITPTRTP-VDFYPSALHP-SGLMKPMMPQESLNGTGCRSEDQNCVPP-LQERKVTPIDSPPVW SPEGYMALQSKGYPLPHPKSSDT-LAMD-MRVR---NESSFSA------SLGRAGGVSAQRDLFEERGEEYLSAFDKKAQ ADFDSCISSQRIGQELLFPPQENVQDAGAPGGHTQ-----NLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVER ETPREGTAFNISSWDKNGS---PNKQPSSEP---------------------EWTPEPRSSSSQHPEQTGRT-RRSGPIK KPVLKALKVEDKEKE--LEKIKQELGEESTR----------------------------LAKEKEQSPT-AEKDEDEE-- ---------------------NDASLANSSTTTLEDKGPGHATFGREATKFEEEE----------KPDKAWEARPP--RE SSDVPPMKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRG----RPAGGNGSGLCGGG-V-LGARSIYCSSQRSGRGRG LREFARPEDCPRAK--------------------PRRRVASETHSEGSEYEELPKRRRQRGSENGNEGSLLEREESTLKK GDCRDSWRSNKGCSEDHSGLDAKSRGPRAFGRALPPRLSNCGYGRRTFVS------KESPHWQSKSPGSSWQEYGP---S DTCGSRRPTDRDYVPDSYRHPD----AFGGRGFEDSRAED------------------KRS-FFQDEHVADSENAENRPF RRRRPPRQDKPPRFRRLRQERESLGLWGPEEE-PHLLAGQWPGRPKLCSGDKSGTV------------------------ --------------GRRSPELSYQNSSDHANEEWETASESSDFSERRERREGPGSEPDSQ------------VDGGLSG- ------ASLGEKKELA---KRSFSSQRPVVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGG LSGCSSGSGHS---------PYALERAAHASADLPEAS--SKKAEKEAKLAAPRAGEQGEAMKQFDLN--YGSAIIENCG SSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVK----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------GRGLSSRIPPRFAKKQNNLCLEQ GDVTVP-----------GSSLGTEIWES---------------------------------------------------- -------------------------------------------------------------------------------S SQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSG-------- -PGLAEPKADSHKEQAPKPSEQKDS-EQGSGQSKEHRP-------GPIGNERSLKNRKGSEGAE---------------- ---RLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDS--DFSLPPGSASGPTGSPVVKLQDALASNAGLTQSIPILRRD H------HIQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSV-----------GASSGVNY SSFGGVSMPPMPVASVAPSASMPG-------------------------------------------------------- ------------------SHLPPLYLDG-HVFASQ-PRLVPQTIPQQQ----SYQQAAAAQQIPISLHTSLQA------- ---------------------QAQLGLRGGLPVSQSQEIFS-SLQPFRS-QVYM------HPSLSPPSTMILSGGTALKP PYSAFPGMQPLEMVKPQSGSPYQPMSGNQ--ALVYEGQLSQAAGLGASQMLDSQLP------------------------ ------------------QLTMPLP-------RYG--SGQQPLILPQSIQLPPGQSLSVGAP-------------RRIPP PGSQPPVLNTSREPSQMEMKGFH----FADSKQNVPSGGP-VPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQ---- -------------------------------------------------------------------------------- -----------------------------------------AKQRVDEKPSLGAVKLQEAPSAASQMK------------ ----------RTGAIKPRAVKVEESKA-------- >Pan_troglodytes_PRRC2B MSDRLGQITKGKDGKSKYSTLSLFDKYK-----GKSVDAIRSSVIPRHGLQSLGKVAAARRMPPPANLPSLKSEN--KGN DPNIVIVPKDGTGWANKQDQQDPKSSSATASQLPESLPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLNGKPVG HEGG--LRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKGVLDLSYGPGPSLRPQ-NVTSWREGGGRHIISATSLSTSPTEL GSRNS-------------------------STGDGAPSSAC------TSDSKDPSLRP-----AQPVRKGAS----QFMG NVYHPPTYHDMLPAF----MCSPKSSENQGTVERGSFPLPQLRLEPRVPFR-----QFQMNDQDGKENRLGLSRP---LR PLRQLVERAPRPTIINAENLKGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNS-----------W DPRRQRQLSMSSADSADAKRT-----QEEGKDWAEAVGA----------------------------------------- ----------------SRVVRKAPDPQPPSRKLHGWAPGPDYQ-KSSMGSMFRQQSIEDKEDKPP-----PRQKFIQS-E MSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPRSPS-------------------- --------------------------------------------------------------AEKASPQENGPAVHKGSP EFPAQETPTTFPEEAPT------------------VSPAVAQSNSS---------EEEAREAGS------PAQEF-KYQK SLPPRFQRQQQQQQQ--------EQLYKMQHW-------------------------QPVYPPP--SHPQRTFYPHHPQM LGFDPRWMMMPSYMDPRITPTRTP-VDFYPSALHP-SGLMKPMMPQESLNGTGCRSEDQNCVPP-LQERKVTPIDSPPVW SPEGYMALQSKGYPLPHPKSSDT-LAMD-MRVR---NESSFSA------SLGRAGGISAQRDLFEERGEEYLSAFDKKAQ ADFDSCISSQRIGQELLFPPQENVQDADAPGGHTQ-----NLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVER ETPREGTAFNISSWDKNGS---PNKQPSSEP---------------------EWTPEPRSSGSQHPEQTGRT-RRSGPIK KPVLKALKVEDKEKE--LEKIKQELGEESTR----------------------------LAKEKEQSPT-AEKDEDEE-- ---------------------NDASLANSSTTTLEDKGPGHATFGREATKFEEEE----------KPDKAWEARPP--RE SSDVPPTKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRG----RPAGGNGSGLCGGG-V-LGARSIYCSSQRSGRGRG LREFARPEDCPRAK--------------------PRRRVASETHSEGSEYEELPKRRRQRGSENGNEGSLLEREESTLKK GDCRDSWRSNKVCSEDHSGLDAKSRGPRAFGRALPPRLSNCGYGRRTFVS------KESPHWQSKSPGSSWQEYGP---S DTCGSRRPTDRDYVPDSYRHPD----AFGGRGFEDSRAED------------------KRS-FFQDEHVADSENAENRPF RRRRPPRQDKPPRFRRLRQERESLGLWGPEEE-PHLLAGQWPGRPKLCSGDKSGTV------------------------ --------------GRRSPELSYQNSSDHANEEWETASESSDFSERRERREGPGSEPDSQ------------VDGGLSG- ------ASLGEKKELA---KRSFSSQRPLVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEALPGG LSGCSSGSGHS---------PYALERAAHVSADPPEAS--SKKAEKEAKLAAPRAGEQGEAMKQFDLN--YGSAIIENCG SSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVK----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------GRGLSSRIPPRFAKKQNNLCLEQ GDVTVP-----------GSSLGTEIWES---------------------------------------------------- -------------------------------------------------------------------------------S SQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSG-------- -PGLAEPKADSHKEQAPKPSEQKDS-EQGSGQSKEHRP-------GPIGNERSLKNRKGSEGAE---------------- ---RLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDS--DFSLPPGSASGPAGSPVVKLQDALASNAGLTQSIPILRRD H------HIQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSV-----------GASSGVNY SSFGGVSMPPMPVASVAPSASMPG-------------------------------------------------------- ------------------SHLPPLYLDG-HVFASQ-PRLVPQTIPQQQ----SYQQAAAAQQIPISLHTSLQA------- ---------------------QAQLGLRGGLPVSQSQEIFS-SLQPFRS-QVYM------HPSLSPPSTMILSGGTALKP PYSAFPGMQPLEMVKPQSGSPYQPMSGNQ--ALVYEGQLSQAAGLGASQMLDSQLP------------------------ ------------------QLTMPLP-------RYG--SGQQPLILPQSIQLPPGQSLSVGAP-------------RRIPP PGSQPPVLNTSREPSQMEMKGFH----FADSKQNVPSGGP-VPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQ---- -------------------------------------------------------------------------------- -----------------------------------------AKQRVDEKPSLGAVKLQEAPSAASQMK------------ ----------RTGAIKPRAVKVEESKA-------- >Pongo_abelii_PRRC2B MSDRLGQITKGKDGKSKYSTLSLFDKYK-----GKSVDAIRSSVIPRHGLQSLGKVAAARRMPPPANLPSLKSEN--KGN DPNIVIVPKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLNGKPVG HEGG--LRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKGVLDLSYGPGPSLRPQ-NVTSWREGGGRHIISATSLSTSPTEL GSRNS-------------------------STGDGAPSSAC------TSDSKDPSLRP-----AQPVRKGAS----QFMG NVYHPPTYHDMLPAF----MCSPKSSENQGTVERGSFPLPQLRLEPRVPFR-----QFQMNDQDGKENRLGLSRP---LR PLRQLVERAPRPTIINAENLKGLDDLDADADDGWAGLHEEVDYSEKLKFSDDEEEEEVVKDGRPKWNS-----------W DPRRQRQLSMSSADSADAKRT-----QEEGKDWAEAVGA----------------------------------------- ----------------SRVVRKAPDPQPPSRKLHGWAPGPDYQ-KSSMGSMFRQQSIEDKEDKPP-----PRQKFIQS-E MSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQARKAGEARKQAEKEVPRSPS-------------------- --------------------------------------------------------------AEKASPQENGPAVRKGSP EFPAQETPTTFPEEAPT------------------VSPAVAQSNSS---------EEEARESGS------PAQEF-KYQK SLPPRFQRQQQQQQQ--------EQLYKMQHW-------------------------QPVYPPP--SHPQRTFYPHHPQM LGFDPRWMMMPSYMDPRITPTRTP-VDFYPSALHP-SGLMKPMMPQESLNGTGCRSEDQNCVPP-LQERKVTPIDSPPVW SPEGYMALQSKGYPLPHPKSSDT-LAMD-MRVR---NESSFSA------SLGRAGGVSAQRDLFEERGEEYLSAFDKKAQ ADFDSCISSQRIGQELLFPPQENVQDAGAPGGHTQ-----NLRCSPLEPDFVPDEKKPECGSWDVSHQPETADTAHGVER ETPREGTAFNISSWDKNES---PNKQLSSEP---------------------EWTPEPRSSSSQHPEQTGRT-RRSGPIK KPVLKALKVEDKEKE--LEKIKQELGEESTR----------------------------LAKEKEQSPT-AEKDEDEED- -------------------EENDASLANSSATTLEDKGPGRATFGHEATKFEEEE----------KPDKAWETRPP--RE SSDVPPTKRNNWIFIDEEQAFGVRGQARGRGRGFREFTFRG----RPAGGNGSSVCGGG-V-LGARSIYCSSQRSGRGRG LREFARPEDCPRAK--------------------PRRRVASETHSEGSEYEELPKRRRQRGSENGNEGSLLEREESTLKK GDCRDSWRSNKVCSEDHSGLDAKSRGPRAFGRALPPRLSNCGYGRRTFIS------KESPHWQSKSPGSSWQEYGP---S DTCGSRRSTDRDYVPDSYRHPD----AFGGRGFEDSRSED------------------KRS-FFQDEHVADSENAENRPF RRRRPPRQDKPPRFRRLRQERESLGLWGPEED-PHLLAGQWPGRPKLCSGDKSGTV------------------------ --------------GRRSPELSYQNSSDHANEEWETASESSDFSERRERREGPGSEPDSQ------------VDGGLSG- ------ASLGEKKELA---KRSFSSQRPLVDRQSRKLEPGGFGEKPVRPGGGDTSPRYESQQNGTPLKVKRSPDEGLPGG LSGCSSGSGHS---------PYALERAAHANADLPEAS--SKKAEKEAKLAAPRAGEQGEAMKQFDLN--YGSAIIENCG SSPGEESEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAVQVPVK----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------GRGLSSRIPPRFAKKQNNLCLEQ GDVTVP-----------GSSLGTEIWES---------------------------------------------------- -------------------------------------------------------------------------------S SQALPVQAPANDSWRKAVTAFSSTETGSAEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSG-------- -PGLAEPKADTHKEQAPKPSEQKDS-EQGSGQSKEHRP-------GPIGNERSLKNRKGSEGAE---------------- ---RLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDS--DFSLPPGSASGPAGSPVVKLQDALASNVRLTQSIPILRRD H------HIQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSV-----------GASSGVNY SSFGGVSMPPMPVASVAPSASMPG-------------------------------------------------------- ------------------SHLPPLYLDG-HVFASQ-PRLVPQTIPQQQ----SYQQAAAAQQIPISLHTSLQA------- ---------------------QAQLGLRGGLPVSQSQEIFS-SLQPFRS-QVYM------HPSLSPPSTMILSGGTALKP PYSAFPGMQPLEMVKPQSGSPYQPMSGNQ--ALVYEGQLSQAAGLGASQMLDSQLP------------------------ ------------------QLTMPMP-------RYG--SGQQPLILPQSIQLPPGQSLSVGAP-------------RRIPP PGSQPPVLNTSREPSQMEMKGFH----FADSKQNVPSGGP-VPSPQTYRPSSASPSGKPSGSAVNMGSVQGHYVQQ---- -------------------------------------------------------------------------------- -----------------------------------------AKQRVDEKPSLGAVKLQEAPSAASQTK------------ ----------RTGAIKPRAVKVEESKA-------- >Mus_musculus_PRRC2B MSDRLGQITQGKDGKSKYSTLSLFDKYK-----GRSVGAVRSSVIPRHGLQSLGKVATARRMPPPANLPSLKSEN--KGN DPNIVIVPKDGTGWANKQDQQDPKSSSVTASQPPESQPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLSGKPVG HEGG--LRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKGALDLSYGPGPSLRPQ-NVTSWREGGGRNIISAASLSASPTEL GSRNA-------------------------SGADGAPSLAC------TSDSKEPSLRP-----AQPSRRGAS----QFMG HGYQPPTYHDMLPAF----MCSPQSSENQTTVERSSFPLPQLRLEPRVPFR-----QFQMNDQDGKE-RPGVARP---VR PLRQLVERAPRPTIINAENLKGLDDLDTDADDGWAGLHEEVDYSEKLKFSDDEDEEDVVKDGRSKWNN-----------W DPRRQRALSLSSADSTDAKRT-----QEEGKDWSGTAGG----------------------------------------- ----------------SRVIRKVPEPQPPSRKLHSWASGPDYQ-KPTMGSMFRQHSAEDKEDKPP-----PRQKFIQS-E MSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCRQAQKANETPKPVEKEVPRSPG-------------------- --------------------------------------------------------------IEKVSPPENGPVVRKGSP EFPVQEAPTMFLEETPA------------------TSPTVAQSNSSSSSSSSSSIEEEVRESGS------PAQEFSKYQK SLPPRFQRQQQQQQQQQQQQQQQEQLYKMQHW-------------------------QPVYPPP--SHPQRTFYPHHPQM LGFDPRWMMMPSYMDPRITPTRTP-VDFYPSALHP-SGLMKPMMPQESLSGTGCRSEDQNCVPS-LQERKVTALDPAPVW SPEGYMALQNKGYSLPHPKSADT-LAMG-MHVR---NERSYCA------SPGRPGGISAQRDLFEERGEEFLSAFDKKAQ ADFDSCISSQRIGQELLFPPQENVQEVGAPGGCTP-----NLRCSPLEPDFVPAEKKPEYGSWDVGHQPKAADTANGVEL EAPRQEPSFHVSSWEKEGS---PKKQPNPEP---------------------EWTPEPRSSSGQHQEQPGRT-RRSGPIK KPVLKALKVEEKEKA--LERGRQGLREESSQ----------------------------RAPEKEPVGR-AEEDE--E-- ---------------------NNPALANAS-SALEDKAASRAGFAHEASKLDEDE----------KADKTWESRPS--RE ASDIPPTKRNNWIFIDEEQAFGGRGQARSRGRGFREFTFRGG---RPAGSSTSGLCGTG-V-LGSRGMYSSGQRSNRGRG LRDFPPPEDCPRAK--------------------PRRRIASETHSEGSEYEELPKRRRQRGSEHSHEGMLTERDEGALK- ----DSWRSNRTYTEDQGGIDTRSRGSRTCGRALPPRLSNCSYGRRTFVA------KEPPHWQSRSPGSSWQEYGS---S DPCGPRRGTDRDYIPDSYRQSD----TFGSRLFEDSRTED------------------KRS-FFQDDHGADSENAENRPF RRRRPPRQDKPPRFRRLRQERESLGLWGPEEE-SHLLASQWPGRSKLCPGDKSGPG------------------------ --------------GHRSPELSYQNSSDHANEEWETASESSDFSERRERREGLVAEPEAQ------------GDGGLSG- ------SSLGEKKELA---KRSFSSQRPLADRQSRKLEPGGFGEKPVRPGGGEPSPRCESQQSGTPLKVKRSPDEALPGG LG------SHS---------PYALERTTHASSDGPETP--SKKSEREVSLPTQRASEQEEARKQFDLG--YGNALIDNCA SSPGEENEASSVVGEGFIEVLTKKQRRLLEEERRKKEQAAQVPVK----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------GRGLSSRIPPRFAKKQNGLCLEQ -DVTVP-----------GSSLGTEIWEN---------------------------------------------------- -------------------------------------------------------------------------------S SQALPVQGAASDSWRTAVTAFSSTEPGTSEG-FKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEISG-------- -PGLAESKADSHKDQAQKQAEHKDS-EQGSAQSKEHRP-------GPIGNERSLKNRKGSEGAE---------------- ---RLPGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDS--DFSLPPGSVSGPVGNPVAKLQDVLASNAGLTQSIPILRRD H------HMQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSV-----------GASNGVNY SSFGGVSMPPMPVASVAPSASIPG-------------------------------------------------------- ------------------SHLPPLYLDG-HVFASQ-PRLVPQTIPQQQ----SYQQAATAQQIPISLHTSLQA------- ---------------------QAQLGLRGGLPVSQSQEIFS-SLQPFRS-QVYM------HPSLSPPSTMILSGGTALKP PYSAFPGIQPLEMVKPQSGSPYQPMSGNQ--ALVYEGQLGQAAGLGTSQMLDSQLP------------------------ ------------------QLTMPLP-------RYG--SGQQPLILPQSIQLPPGQSLSVGAP-------------RRVPP PGSQPPVLNTSRESAPMELKGFH----FADSKQNVPTGGS-APSPQAYRPSSASPSGKPSGSAVNMGSVQGHYVQQ---- -------------------------------------------------------------------------------- -----------------------------------------AKR-VDEKPGLGTVKLQEASSATSQMK------------ ----------RTGAIKPRAVKVEGSKA-------- >Rattus_norvegicus_PRRC2B MSDRLGQITQGKDGKSKYSTLSLFDKYK-----GRSVGAVRSSVIPRHGLQSLGKVATARRMPPPANLPSLKSEN--KGN DPNIVIVPKDGTGWANKQDQQDPKSSSVTASQLPESQPQPGLQKSVSNLQKPTQSISQENTSSVPGGPKSWAQLSGKPVG HEGG--LRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKGALDLSYGPGPSLRPQ-NVSSWREGGGRNIISAVSLSASPTEL GSRNS-------------------------SGGDGASSSAC------TSDSKDPSLRP-----AQPSRKGAS----QFMG HVYQPPTYHDMLPAF----MCSPQSSENQNTVERSSFPLPQLRLEPRVPFR-----QFQMNDQDGKE-RPGVARP---VR PLRQLVERAPRPTIINAENLKGLDDLDTDADDGWAGLHEEVDYSEKLKFSDDEDEEDVVKDGRSKWNN-----------W DPRRQRALSLSSADSTDAKRT-----QEEGKDWSGTAGV----------------------------------------- ----------------SRVVRKVPEPQPPSRKLHSWASGPDYQ-KPTMGSMFRPQSIEDKEDKPP-----PRQKFIQS-E MSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCRQAQKASETPKPVEKEVPRSPG-------------------- --------------------------------------------------------------IEKLSPPENGPVVRKGSP EFPVQEAPTMFLEETPA------------------TSPTVAQSNNSSSSSSSS-IEEEVREAGS------PAQEFSKYQK SLPPRFQRQQQQQQQQQQQQQQQEQLYKMQHW-------------------------QPVYPPP--SHPQRTFYPHHPQM LGFDPRWMMMPSYMDPRITPTRTP-VDFYPSALHP-SGLMKPMMPQESLSGTGCRSEDQNCVPS-LQERKVTAIDPAPVW SPEGYMALQNKGYSLSHPKSADT-LAMG-MHVR---NERSYCA------SPGRSGGISAQRDLFEERGEEFLSAFDKKAQ ADFDSCISSQRIGQELLFPPQENVQEVGAPGGCTP-----NLRCSPLEPDFVPAEKKPECGSWDVGHQPKAADMANSVEL EAPRQEPSFHVSSWEKEGS---PKKQPNPEP---------------------EWTPEPRSSSGQQQEQPGRT-RRSGPIK KPVLKALKVEEKEKA--LERVRQGLGEESSQ----------------------------RATEKEPPCR-AEEDEDEE-- ---------------------NNPALANAS-SALEDKAAARGGFGHEASKLDEEA----------KTDKTWESRPS--RE ASEIPPPKRNNWIFIDEEQAFGGRAQARSRGRGFREFTFRGG---RPTSSSTSGLCGTG-V-LGSRGMYSGGQRSNRGRG LRDFPPPEDCPRAK--------------------PRRRIASETHSEGSEYEELPKRRRQRGSEPSHEGMLTERDEGALK- ----DSWRSNRTYTEDQGSLDARSRGPRTCGRALPPRLSNCSYGRRTFVA------KEPPHWQSRSPGNSWQEYGS---S DPCGPRRATDRDYIPDSYRHSD----TFGSRLFEDSRTED------------------KKS-FFQDDHGADSEGAENRPF RRRRPPRQDKPPRFRRLRQERESLGLWGPEEE-SHLLASQWPGRSKLCPGDKSGPG------------------------ --------------GHRSPELSYQNSSDHANEEWETASESSDFSERRERREGLAAEPEAQ------------GDGGLSG- ------ASLGEKKELA---KRSFSSQRPLADRQSRKLEPGGFGEKPVRPGGGETSPRCESQQSGTPLKVKRSPDEALPGG LG------SHS---------PYALERTTHGSSDGSETT--SKKTEKEVSLAAQRAGEQEEARKQFDLG--YGNAIIDNCG SSPGEENEVGSMVGEGFIEVLTKKQRRLLEEERRKKEQAAQVSVK----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------GRGLSSRIPPRFAKKQNGLCLEQ GDVAVP-----------GSSLGTEIWES---------------------------------------------------- -------------------------------------------------------------------------------S SQALPVQGAASDSWRTAVTAFSSAEPGTSEG-FKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPDEMSG-------- -PGLAESKADSHKDQAQKQSEHKDS-EQGSGQSKEHRP-------GPIGNERSLKNRKGSEGAE---------------- ---RLQGAVVPPVNGVEIHVDSVLPVPPIEFGVSPKDS--DFSLPPGSVSGPVGNPVAKLQDVLASNAGLTQSIPILRRD H------HIQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQNSPGGAGSGIQPPSSV---------