>Homo_sapiens_STXBP1 ------------------------------------------------------------------------------MA PIGLKAVVGE-KIMHDVIKKV--------------KKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLEAVYLITPSEK---------------------------SVHSLISDFKDPP--TAKYRAAHVFFTD--------- ---------------------------------------------SCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQ VYSLDSADSFQSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GEYKDNALLAQLIQDKLD-AYK ADDPTMGEG-PDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIV-----TDSTLRR---------- -------------------------RSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKAP-GEYRSG-PRLIIFILGGV SLNEMRCAYEVT----QANGKWEVLIG-S-------------THILTPTKFLMDLRHPDFRE------------SSRVSF EDQAPTME----------------------------------------------------- >Pongo_abelii_STXBP1 -------------------------------------------------------------------------------- ------------IMHDVIKKV--------------KKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLEAVYLITPSEK---------------------------SVHSLISDFKDPP--TAKYRAAHVFFTD--------- ---------------------------------------------SCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQ VYSLDSADSFQSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GEYKDNALLAQLIQDKLD-AYK ADDPTMGEG-PDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIV-----TDSTLRR---------- -------------------------RSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKAP-GEYRSG-PRLIIFILGGV SLNEMRCAYEVT----QANGKWEVLIG-S-------------THILTPQKLLDTLKKLNKTD------------EEISS- ------------------------------------------------------------- >Macaca_mulatta_STXBP1 ------------------------------------------------------------------------------MA PIGLKAVVGE-KIMHDVIKKV--------------KKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLEAVYLITPSEK---------------------------SVHSLISDFKDPP--TAKYRAAHVFFTD--------- ---------------------------------------------SCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQ VYSLDSADSFQSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GEYKDNALLAQLIQDKLD-AYK ADDPTMGEG-PDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIV-----TDSTLRR---------- -------------------------RSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKAP-GEYRSG-PRLIIFILGGV SLNEMRCAYEVT----QANGKWEVLIG-S-------------THILTPTKFLMDLRHPDFRE------------SSRVSF EDQAPTME----------------------------------------------------- >Mus_musculus_STXBP1 ------------------------------------------------------------------------------MA PIGLKAVVGE-KIMHDVIKKV--------------KKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLEAVYLITPSEK---------------------------SVHSLISDFKDPP--TAKYRAAHVFFTD--------- ---------------------------------------------SCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQ VYSLDSADSFQSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GEYKDNALLAQLIQDKLD-AYK ADDPTMGEG-PDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIV-----TDSTLRR---------- -------------------------RSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKAP-GEYRSG-PRLIIFILGGV SLNEMRCAYEVT----QANGKWEVLIG-S-------------THILTPTKFLMDLRHPDFRE------------SSRVSF EDQAPTME----------------------------------------------------- >Felis_catus_STXBP1 -------------------------------------------------------------------------------- -FVLFLSPFL-EIMHDVIKKV--------------KKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLEAVYLITPSEK---------------------------SVHSLISDFKDPP--TAKYRAAHVFFTD--------- ---------------------------------------------SCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQ VYSLDSADSFQSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GEYKDNALLAQLIQDKLD-AYK ADDPTMGEG-PDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIV-----TDSTLRR---------- -------------------------RSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKAP-GEYRSG-PRLIIFILGGV SLNEMRCAYEVT----QANGKWEVLIG-S-------------THILTPTKFLMDLRHPDFRE------------ASRVSF ED----------------------------------------------------------- >Myotis_lucifugus_STXBP1 ------------------------------------------------------------------------------TR PVGR-KMTES-KIMHDVIKKV--------------KKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKCRE PLPSLEAVYLITPSEK---------------------------SIRSLMNDFKDPP--TAKYRAAHVFFTD--------- ---------------------------------------------SCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQ VYSLDSADSFQSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GEYKDNALLAQLIQDKLD-AYK ADDPTMGEG-PDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGEARVKEVLLDEDDDLWITLRHKHIAEVSQEVTRSLKDFSSS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIV-----TDSTLRR---------- -------------------------RSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKAP-GEYRSG-PRLIIFILGGV SLSEMRCAYEVT----QANGKWEVLIG-S-------------THILTPTKFLMDLRHPDFRE------------SSRVSF EDQAPTME----------------------------------------------------- >Ornithorhynchus_anatinus_STXBP1 -------------------------------------------------------------------------------- LSPIGFIVTK-EIMHDVIRKV--------------KKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLEAVYLITPSEK---------------------------SVHSLISDFKDPP--TAKYRAAHVFFTD--------- ---------------------------------------------SCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQ VYSLDSADSFQSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GDYKDNAMLAQLIQDKLD-AYK ADDPTMGEG-PDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGEARVKEVLLDEDDDLWITLRHKHIAEVSQEVTRSLKDFSSS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDG NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPII-----TDSTLRR---------- -------------------------RSKPERKERISEQTYQLSRWTPVIKDIMEDTIDDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKAP-GEYRTG-PRLIIFILGGV SLNEMRCAYEVT----QANGKWEVLIG-S-------------THILTPTKFLMDLRHPDFRE------------FTRVSF EDQAPTVE----------------------------------------------------- >Gallus_gallus_STXBP1 -------------------------------------------------------------------------------- -----------EIMHDVIRKV--------------KKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLEAVYLITPSEK---------------------------SVHSLISDFKDPP--TSKYRAAHVFFTD--------- ---------------------------------------------SCPDALFNELVKSRAAKVIKTLTEINIAFLPSESQ VYSLDSADSFQSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GDYKDNAMLAQLIQDKLD-AYK ADDPTMGEG-PDKARSQLLILDRGFDPASPVLHELTFQAMSYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGEARVKEVLLDEDDDLWVSLRHKHIAEVSQEVTRSLKEFSSS---KRMNTG--DKTT MRDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDG NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPAEDSEIITNMAHLGVPII-----TDSTLRR---------- -------------------------RSKPERKERISEQTYQLSRWTPVIKDIMEDAIEDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKAP-GEYRSG-PRLIIFILGGV SMNEMRCAYEVT----QASGKWEVLIG-S-------------THILTPTKFLMDLRHPDFRD------------STRVSF EDQAPAME----------------------------------------------------- >Taeniopygia_guttata_STXBP1 -------------------------------------------------------------------------------- ----------------------------------------------------------------------VVEDINKRRE PLPSLEAVYLITPSEK---------------------------SIHSLINDFKDPP--TSKYRAAHVFFTD--------- ---------------------------------------------SCPDALFNELVKSRAAKVIKTLTEINIAFLPSESQ VYSLDSADSFQSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GDYKDNAMLAQLIQDKLD-AYK ADDPTMGEG-PDKARSQLLILDRGFDPASPVLHELTFQAMSYDLLPIENDLK---------------------------- -------------------------------------------------------------------------------- -----------GYETSG-----IGEARIKEVLLDEDDDLWVTLRHKHIAEVSQEVTRSLKEFSSS---KRMNTG--DKEE GWDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDG NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPAEDSEIITNMAHLGVPII-----TDSTLRR---------- -------------------------RSKPERKERISEQTYQLSRWTPVIKDIME-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Xenopus_tropicalis_STXBP1 ---------------------------------------------------------------------------LQGTE KTRGKLDRVGQEIMHDVIRKV--------------KKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PIPSLEAVYLITPSEK---------------------------SVHSLISDFKDPP--SSKYRAAHVFFTD--------- ---------------------------------------------SCPDTLFNELVKSRTSKMIKTLTEINIAFLPYESQ VFSLDYPDSFHSFYS--PHKAQMKNPILERLAEQIATLCATLKEYPAVRYR-------GDYKDNAMLSQLIQDKLD-AYK ADDPTMGEG-PDKARSQLIILDRGFDPASPILHELTFQAMSYDLLPVENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGDQRMKEVLLDEDDDLWVTLRHKHIAEVSQEVTRSLKDFSAS---KRMNTG--DKTT MRDLSQMLKKMPQYQKELSKYS----THLHLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDG NVSTYDKIRIINLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPII-----TDSTLRR---------- -------------------------RSKPDRKERISEQTYQLSRWTPVVKDIMEDTIDDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKAP-GEYRAG-PRLIIFILGGV ALSEMRCAYEVS----QANGKWEVLIG-S-------------THILTPTKFLEDLRHPDFRD------------SSRVSF EDPAPIME----------------------------------------------------- >Danio_rerio_STXBP1_a ------------------------------------------------------------------------------MA PIGLKAVVGE-KIMNDVIKKV--------------KKKGEWKALIVDQLSMRMLSSCCKMTDIMTEGIT-IVEDIMKRRE PLPSLEAIYLITPTDK---------------------------SVQTLINDFKDPH--SAKYKGAHVFFTD--------- ---------------------------------------------SCPDPLFNEVVKSRASKTIKTLNEINIAFLPYESQ VFSLDNPDAFQSFYS--PHKTQLKNPVMERLAEQLATLCATLKEYPAVRYR-------GEYKDNATLAQLLQDKLD-AYK ADDPTMGEG-PDKARSQLIILDRGFDPVSPVLHELTFQAMAYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYDTSG-----IGDSREKEVLLHEDDDLWVALRHKHIAEVSQEVTRSLKEFSAS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLQLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVTTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPII-----TDSTLRR---------- -------------------------GKKMDRKERVSEQTYQLSRWTPLIKDIMEDAIDDKLDTKHYPYISTRS-----SS S----------------------------------------FSTSAVS-ARYGHWHKNKTP-GEYRTG-PRIMVFIIGGA SFSEMRCAYEVT----QANGKWEAIVG-S-------------THSLTPTKFLMDLRHPDFRE------------STRVSF EDPDPSDE----------------------------------------------------- >Takifugu_rubripes_STXBP1_a ------------------------------------------------------------------------------MA PIGLKAVVGE-KIMNDVIKKV--------------KKKGEWKALIVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLESIYLITPTEK---------------------------SVRTLISDFKDPH--SAKYKAAHVFFTD--------- ---------------------------------------------SCPDPLFNELVKSRTSKVTKTLTEINIAFLPYESQ VYSLDNPDAFHSFYS--PHKTQLKNPVMERLAEQIATLCATLKEYPAVRYR-------GEYKDNATLAQLVQDKLD-AYK ADDPTMGEG-PDKARSQLIILDRAFDPVSPVLHELTFQAMGYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGDSREKEVLLHEDDDLWVSLRHKHIAEVSQEVTRQLKEFSSS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLQLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPII-----TDSTLRR---------- -------------------------GKKLDRKERVSEQTYQLSRWTPLVKDIMEDAIDDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKTP-GEYRTG-PRVLVFIIGGV SFSEMRCAYEVT----QANGKWEAIIG-S-------------THTLTPTKFLSDLQHPDFRE------------STRVSF E------------------------------------------------------------ >Tetraodon_nigroviridis_STXBP1_a ------------------------------------------------------------------------------MA PIGLKAVVGE-SVFDQVIKKK--------------KKKPSFG-VFQDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLEAIYLITPTEK---------------------------SVRTLISDFKDPH--SSKYKAAHVFFTD--------- ---------------------------------------------SCPDPLFNELVKSRTSKVTKTLTEINIAFLPYESQ VYSLDNPDAFHSFYS--PHKTQLKNPVMERLAEQIATLCATLKEYPAVRYR-------GEYKDNATLAQLVQDQLD-AYQ ADDPTMGEG-PDKARSQLIILDRAFDPVSPVLHELTFQAMGYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGDSREKEVLLHEDDDLWVSLRHKHIAEVSQEVTRQLKEFSSS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLQLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVSTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPII-----TDSTLRR---------- -------------------------GKKVDRKERVSEQTYQLSRWTPLVKDIMEDAIEDKLDLKLFPYISQRQ-----VS T----------------------------------------KASAPSSSARYGNWHKNRGP-TEMKTG-PRIIVFIIGGV TYSEMRCVYEVT----QANGKWEALIG-S-------------THILTPPKYLKELQHADFLD------------PSAAE- ------------------------------------------------------------- >Gasterosteus_aculeatus_STXBP1_a ------------------------------------------------------------------------------MA PIGLKAVVGE-KIMNDVIKKV--------------KKKGEWKALIVDQLSMRMLSSCCKMTDIMTEGIT-IVEDIMKRRE PLPSLEAIYLSLFSEE---------------------------SVHTLIGDFKDPH--SAKYKAAHVFFTD--------- ---------------------------------------------SCPDPLFNELTKSRASKTIKTLTEINIAFLPYESQ VYSLDNPDAFHSFYS--PHKTQLKNPVMERLAEQLATLCATLKEYPAVRYR-------GEYKDNATLAQLVQDKLD-AYK ADDPTMGEG-PDKARSQLIILDRAFDPVSPVLHELTFQAMGYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYETSG-----IGDSREKEVLLHEDDDLWVSLRHKHIAEVSQEVTRQLKDFSAS---KRMNTAG-EKTT MRDLSQMLKKMPQYQKELSKYS----THLQLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVTTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIV-----TDSTLRR---------- -------------------------GKKLDRKERVSEQTYQLSRWTPLVKDIMEDAIEDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVSSARYGHWHKNKTP-GEYRTG-PRVMVFIIGGA SFSEMRCAYEVT----QANGKWEAVIAGS-------------THIFTPTSLLEQLKAMNKPD------------EEVAS- ------------------------------------------------------------- >Oryzias_latipes_STXBP1_a ------------------------------------------------------------------------------MA PIGLKAVVGE-KIMNDVIKKV--------------KKKGEWKALIVDQLSMRMLSSCCKMTDIMTEGIT-IVEDINKRRE PLPSLEAIYLITPTEK---------------------------SVNTLIADFKDPH--SSKYKAAHVFFTD--------- ---------------------------------------------SCPDPLFNEVVKSRASKVVKTLTEINIAFLPYESQ VYSLDNPDAFHSFYS--PHKTQLKNPVMERLAEQLATLCATLKEYPAVRYR-------GEYKDNATLAQLVQDKLD-AYK ADDPTMGEG-PDKARSQLIILDRAFDPVSPVLHELTFQAMGYDLLPIENDVY---------------------------- -------------------------------------------------------------------------------- -----------KYDTSG-----IGDSRTKEVLLHEDDDLWVSLRHKHIAEVSQEVTRQLKEFSAS---KRMNTG--EKTT MRDLSQMLKKMPQYQKELSKYS----THLQLAEDCMKHYQGTVDKLCRVEQ--DLAMGTDAEGEKIKDPMRAIVPILLDA NVTTYDKIRIILLYIFL----KNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPII-----TDSTLRR---------- -------------------------GKKMDRKERVSEQTYQLSRWTPLVKDIMEDAIEDKLDTKHYPYISTRS-----SA S----------------------------------------FSTTAVS-ARYGHWHKNKTP-GEYRTG-PRVMVFILGGV SFSEMRCAYEVT----QANGKWEAIIG-A-------------THTLTPTKFLSDLQHPD--------------------- ------------------------------------------------------------- >Ciona_intestinalis_STXBP1 -------------------------------------------------------------------------------- -MALKALIGE-RIMNDVVRQV--------------KTKSKWKILVLDRLSVRIISSCCKMKDIIDEGIT-LVEDLTKTRQ PMPAFEVVYFVTPCKD---------------------------SVEHIIDDFVDD----RKYKHVHIFFTD--------- ---------------------------------------------SCSDPLFKMLCQSNVSKYIKSLKEVNIAFLPYESQ VFTLDCPDSFEAIYS--PGHTDKRDKCMERVAEQLSTLCAVLGEYPSIRYR-------QEGEKSLLLAQLLQSKLD-GFK ADKPDMGEG-PDKSRSQLIILDRGFDPVSVLVHELTYQAMVQDLLPISNDVY---------------------------- -------------------------------------------------------------------------------- -----------KYENQQQ-----PGQPEKQVLLDEDDDLWVSLRHEHIAVVSQKVTSHLKSFAKE---KRMDSG--EKTT MRDLSNMLKKMPQYQKELSKYS----THLHMAEDCMKQYTDRVDKLCKVEQ--DLVMGTDAKGNHIKEPMKSVVHILLDK DVQPFDKIRIILLYIVL----KNGIPEENLKKLIHHAEISEADQASIRNFNHLGVTIV-----NNENRKK---------- --------------------------SGPKLERREHEATYQLSRWVPIIKDIMEMAIDDKLDQRLFPFLSGRG-----SG S-----------------------------------------GSTSVKSARY-HWHKDKGP-SDYKSG-PRLIIFVIGGM SCSEMRTAYEVTKRLRDKGDKWEVLIGST--------------LVAKPVSFLEDVSRLTKT----------------ISF ------------------------------------------------------------- >Drosophila_melanogaster_STXBP1 -------------------------------------------------------------------------------- -MALKVLVGQ-KLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEGIT-LVEDINKKRE PLPTMDAIYLITPSDE---------------------------SVRGLIRDFENPA--RPMYRYAHVFFTE--------- ---------------------------------------------VCPEELFNDLCKSCAAGKIKTLKEINIAFLPYECQ VFSLDSPDTFQCLYS--PAFASIRSKHIERIAEQIATLCATLGEYPNVRYR-------SDWDRNIDLAASVQQKLD-AYK ADDATMGEG-PEKARSQLLILDRGFDCVSPLLHELTLQAMAYDLLPIVNDVY---------------------------- -------------------------------------------------------------------------------- -----------RYTPGP-------NQPDKEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFTDS---KRMGSA--DKSS MRDLSQMIKKMPQYQKELSKYS----THLHLAEDCMKSYQNYVDKLCRVEQ--DLAMGTDAEGEKIKDHMRNIVPILLDA NVSNYDKVRIIALYVMI----KNGISEENLTKLFTHAQLSPKDQDMVRNLSCLGINVI-----AD--SRKKQ-------- --------------------------YSVPRKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLEGRA-----QN TN----------------------------------------YHAPTS-ARYGHWHKDKGQ--AQVKNVPRLIVFIVGGV SMSEMRCAYEVTN----AVRNWEVLVGSS--------------HILSPEIFLSDLGSLSK---------------ED--- ------------------------------------------------------------- >Homo_sapiens_STXBP2 ------------------------------------------------------------------------------MA PSGLKAVVGE-KILSGVIRSV--------------KKDGEWKVLIMDHPSMRILSSCCKMSDILAEGIT-IVEDINKRRE PIPSLEAIYLLSPTEKAQAQRVIHLPQ----------------SVQALIKDFQGTP--TFTYKAAHIFFTD--------- ---------------------------------------------TCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQ VFSLDAPHSTYNLYC--PFRAEERTRQLEVLAQQIATLCATLQEYPAIRYR-------KGPEDTAQLAHAVLAKLN-AFK ADTPSLGEG-PEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTY---------------------------- -------------------------------------------------------------------------------- -----------RYETTG-----LSEAREKAVLLDEDDDLWVELRHMHIADVSKKVTELLRTFCES---KRLTTD---KAN IKDLSQILKKMPQYQKELNKYS----THLHLADDCMKHFKGSVEKLCSVEQ--DLAMGSDAEGEKIKDSMKLIVPVLLDA AVPAYDKIRVLLLYILL----RNGVSEENLAKLIQHANVQA-HSSLIRNLEQLGGTVT-----NPGGSGT---------- -------------------------SSRLEPRERM-EPTYQLSRWTPVIKDVMEDAVEDRLDRNLWPFVSDPA-----PT A----------------------------------------SSQAAVS-ARFGHWHKNKAG-IEARAG-PRLIVYVMGGV AMSEMRAAYEVTR---ATEGKWEVLIGSS--------------HILTPTRFLDDLKALDKK-------------LEDIAL P------------------------------------------------------------ >Pan_troglodytes_STXBP2 ------------------------------------------------------------------------------MA PSGLKAVVGE-KILSGVIRSV--------------KKDGEWKVLIMDHPSMRILSSCCKMSDILAEGIT-IVEDINKRRE PIPSLEAIYLLSPTEKAQAQRVIHLPQ----------------SVQALIKDFQGTP--TFTYKAAHIFFTD--------- ---------------------------------------------TCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQ --------------------AEERTRQLEVLAQQIATLCATLQEYPAIRYR-------KGPEDTAQLAHAVLAKLN-AFK ADTPSLGEG-PEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTY---------------------------- -------------------------------------------------------------------------------- -----------RYETTG-----LSEAREKAVWLDEDDDLWVELRHMHIADVSKKVTELLRTFCES---KRLTTD---KAN IKDLSQILKKMPQYQKELNKYS----THLHLADDCMKHFKGSVEKLCSVEQ--DLAMGSDAEGEKIKDSMKLIVPVLLDA AVPAYDKIRVLLLYILL----RNGVSEENLAKLIQHANVQA-HSSLIRNLEQLGGTVT-----NPGGSGT---------- -------------------------SSRLEPRERM-EPTYQLSRWTPVIKDVMEDAVEDRLDRKLWPFVSDPA-----PT A----------------------------------------SSQAAVS-ARFGHWHKNKAG-VEARAG-PRLIVYVMGGV AMSEMRAAYEVTR---ATEGKWEVLIGSS--------------HILTPTRFLDDLKTLDKK-------------LEDIAL P------------------------------------------------------------ >Macaca_mulatta_STXBP2 ------------------------------------------------------------------------------MA PSGLKAVVGE-KILSGVIRSV--------------KKDGEWKVLIMDHPSMRILSSCCKMSDILAEGIT-IVEDINKRRE PIPSLEAIYLLSPTEK---------------------------SVQALIADFRGTP--TFTYKAAHIFFTD--------- ---------------------------------------------TCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQ VFSLDAPHSTYNLYC--PFRAGEHARQLEVLAQQIATLCATLQEYPAIRYR-------KGPEDTAQLAHAVLAKLN-AFK ADTPSLGEG-PEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTY---------------------------- -------------------------------------------------------------------------------- -----------RYETTG-----LSEAREKAVLLDEDDDLWVELRHMHIADVSKKVTELLRTFCES---KRLTTD---KAN IKDLSQILKKMPQYQKELNKYS----THLHLADDCMKHFKGSVEKLCSVEQ--DLAMGSDAEGEKIKDSMKLIVPVLLDA AVPAYDKIRVLLLYILL----RNGVSEENLAKLIQHANVQA-HSSLIRNLEQLGGTVT-----NPG-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Mus_musculus_STXBP2 ------------------------------------------------------------------------------XA PLGLKAVVGE-KILSGVIRSV--------------KKDGEWKVLIMDHPSMRILSSCCKMSDILAEGIT-IVEDINKRRE PIPSLEAIYLLSPTEK---------------------------SVQALIADFQGTP--TFTYKAAHIFFTD--------- ---------------------------------------------TCPEPLFSELGRSRLAKAVKTLKEIHLAFLPYEAQ VFSLDAPHSTYNLYC--PFRAGERGRQLDALAQQIATLCATLQEYPSIRYR-------KGPEDTAQLAHAVLAKLN-AFK ADTPSLGEG-PEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTY---------------------------- -------------------------------------------------------------------------------- -----------RYETTG-----LSESREKAVLLDEDDDLWVELRHMHIADVSKKVTELLKTFCES---KRLTTD---KAN IKDLSHILKKMPQYQKELNKYS----THLHLADDCMKHFKGSVEKLCSVEQ--DLAMGSDAEGEKIKDAMKLIVPVLLDA SVPPYDKIRVLLLYILL----RNGVSEENLAKLIQHANVQS-YSSLIRNLEQLGGTVT-----NSAGSGT---------- -------------------------SSRLERRERM-EPTYQLSRWSPVIKDVMEDVVEDRLDRKLWPFVSDPA-----PV P----------------------------------------SSQAAVSSARFGHWHKNKAG-VEARAG-PRLIVYIVGGV AMSEMRAAYEVTR---ATEGKWEVLIGSS--------------HILTPTRFLDDLKTLDQK-------------LEGVAL P------------------------------------------------------------ >Equus_caballus_STXBP2 -------------------------------------------------------------------------------G ASGLKAVVGE-KILSGVIRSV--------------KKDGEWKVLIVDHPSMRILSSCCKMSDILAEGIT-IVEDINKRRE PIPSLEAIYLLSPTEK---------------------------SVQALIADFRGTP--TFTYKAAHVFFTD--------- ---------------------------------------------TCPEHLFNELGRSRLAKVVKTLKEIHLAFLPYEAQ VFSLDAPHSTYNLYC--PFRAGERARQLEALAQQIATLCATLQEYPAIRYR-------KGPEDTAQLAHAVLAKLN-AFK ADTPSLGEG-PEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDMY---------------------------- -------------------------------------------------------------------------------- -----------RYETTG-----LSEAREKAVLLDEDDDLWIELRHMHIADVSKKVTELLKTFCES---KRMTTD---KAN IKDLSHILKKMPQYQKELNKYS----THLHLADDCMKRFKGSVEKLCSVEQ--DLAMGSDAEGEKIKDAMKLIVPVLLDT AVPAYDKIRVLLLYILL----RNGVSEENLAKLIQHANVQA-HSSLIRNLEQLGGTIT-----NTGGCGT---------- -------------------------SSRLGRRERS-EPTYQLSRWTPVIKDVMEDAVEDRLDRKLWPFVSDPA-----PT P----------------------------------------SSQAAVRPVTGAGGRGNKPA-WEARAGGQGSLIYVHGGA GQGTEMRARRRTQ---ATQ-KWKVLIGSS--------------HILTPTRFLDDLKTLDQK-------------LENIAL P------------------------------------------------------------ >Anolis_carolinensis_STXBP2 ------------------------------------------------------------------------------MA PAGLKAVVGE-KILNDVIRSM--------------KKEGEWKVLVMDHTSTRILSSCFKMSDLLAEGIT-IIEDINKRRE PLPSLEAIYLISPIET---------------------------SVHALINDFKSTP--TFAYKAAHVFFTD--------- ---------------------------------------------TCPENLFNELSKSKITKAIKTLKEINVAFLPYESQ VYTLDHPQSFHHLFS--PYCREDKNKHLERMAEQIATLCDTLKEYPSIRYR-------NGSEDCVLLAHAVLAKLN-AFK ADNPTMGEG-PDKSRSQLLIVDRSYDLVSPLLHELTFQAMAYDLLNIENDTY---------------------------- -------------------------------------------------------------------------------- -----------RYESTG-----ISDSREKVVLLDEDDDLWLQLRHMHIADVSKKVTELLRTFCES---KRLTTD---KAN IKDLSQILKKMPQYQKELHKYS----THLHLAEDCMNSFKGTVERLCNVEQ--DLATGSDVEGEKVKNAMKTIVPIVLDA SVTALDKIRIILLCIFL----QNGINEENLTKLIQHANIQP-EKDILYNMNCLGATIM-----PEDAGG----------- -------------------------HMKPVRKVRL-EPTYQLSRWIPILKDVMEDAIEDKLDKKMWPYVSCPA-----PG P----------------------------------------SSQAAVSSARFGHWHKTKTA-TEYRTG-PRLILYVLGGV TMSEMRCAYEVTE---ATDGKWEVLIGSS--------------HVLTPKQFLEDVRNLTEQ----------------APL KS----------------------------------------------------------- >Danio_rerio_STXBP2_a ------------------------------------------------------------------------------MA PSGLKAIANE-KILSGVIKSV--------------KKDGDWKVLIVDHISMRILSSCCKMSDIMAEGVT-IVEDISKRRE PIPSLEAIYLISPVPK---------------------------SVHALIADFRET---AFTYKAAHVFFTD--------- ---------------------------------------------TCPDGLFAEIGRSRVAKVIKTLKEINVAFIPYESQ VFTLDNPSSFHAFYSPTQTNLDDKSRMMEAMAEQIATLCDTLTEYPAIRYR-------LGPKENFSLAEMVMDRLN-AHK ADNPRMGEG-TDKARSQLLIVDRGYDPVSPILHELTFQAMAYDLLDIEQDIY---------------------------- -------------------------------------------------------------------------------- -----------RYQTAG-----IGEARDKEVLLDEDDELWVQLRHMHIADVTKKVTELLRVFCDS---KRMNTD---KAN IKDLSQMLKKMPQYQKELSLYS----THLNLADACMKKFKNTLDKLCEVEQ--DLAMGSDAQGEPLKDAMKSIVPVLLNT EIKDYDKIRIILLYIFHK---KKGIGEENLTKLIQHANVQQ-DKNIITNLQHLGCPII-----TGGANSG---------- -------------------------KSLPDRKERT-ESTYQLSRWIPVLKDVMENIIDDKCDRKQWPFLSEPA-----PI T----------------------------------------TTATTVSSARFGHWHKNKSA-TEYRSG-PRLIIFVIGGV THSEMRCAYEVTR---ATEGKWEVLIGSS--------------HIITPTSFLNDLKELDAS-------------ATSVAQ ------------------------------------------------------------- >Takifugu_rubripes_STXBP2_a ---------------------------------------------------------------------------TVKMA PIGLKAIVGE-KILNGVIKSV--------------KKDGEWKVLIVDHMSMRILSSCCKMSDILAEGVT-IVEDINKRRE PISSLEAIYLISPVEK---------------------------SVHALINDFKYG---AFAYKAAHIFFTD--------- ---------------------------------------------NCPDSLFTAIGRSRVAKVAKTLKEINVAFLPYESQ VFSLDDPTSLYSFYSSKPN--EKKDQMMETIAEQIATLCDTLKEYPAIRYRKYKGFALKGPEENARLAEEVYQRLN-AHK ADNPSMGEG-ADKARSQLLIVDRGFDPVSPVLHELTLQAMAYDLLDIKHDIY---------------------------- -------------------------------------------------------------------------------- -----------TYQTSG-----IGSSTEREVLLDEDDELWIQLRHLHIADVTKKVKDLLRSFCES---KRMSTD---NAN IKDLSQMLKKMPQYQKELSMYA----THLNLADACMKKFKASLDKLCEVEQ--DLAMGENAEGEQLKDPMKSIVPVLLNT EIQAYDKIRIILLYIFHT---KKGIREENLAKLIQHANIQE-DSIIISNLQNLGCNIL-----AGGRNAG---------- -------------------------KTLPERKERK-ESTYQLSRWTPIIKDIMENAIEDKLDKKQWPFISDPA-----PI N----------------------------------------TSQTTVSSARFGQWHKNKT--TEYHTG-PRLIVFVIGGV SHSEMRSAYEVTK---ATQGKWEVVIGSS--------------HILTPTSFLNDLKSLDQV-------------PNPD-- ------------------------------------------------------------- >Gasterosteus_aculeatus_STXBP2_a -------------------------------------------------------------------------------- -SGLKAVVGE-KILNGVIKSV--------------KKEGEWKVLIVDHMSMRILSSCCKMSDILAEGVT-IVEDINKRRE PISSLEAIYLISPVEK---------------------------SVRALIDDFKDA---AFTYKAAHIFFTD--------- ---------------------------------------------TCPDGLFAEIGRSRVAKVVKTLKEINVAFLPYESQ VFSLDDPNSLYSFYSSKPN--EGKEKMIETLAEQIATLCDTLKEYPAIRYR-------KGPEENARLADEVYQRLT-AHK ADNPTMGEG-ADKARSQLLIVDRGFDPISPILHELTFQAMAYDLLDIKQDIY---------------------------- -------------------------------------------------------------------------------- -----------SYQSTG-----IGNSNDREVLLDEDDELWVALRHMHIADVTKKVTELLQTFCQS---KRMNTD---NAN IKDLSQMLKKMPQYQKELSMYS----THLHLAGACMKTYKASVDKLCEVEQ--DLAMGENEEGEPLKDAMKSIVPVLLDN EIKAYDKIRIILLYIFHM---KKGIGEENLAKLIQHANIMA-DSNIINNLQNLGCNII-----AGGRNAG---------- -------------------------ITLPERKQRT-ESTYQLSRWVPIIKDVMENAIEDKLDRKQWPFISDPA-----PI N----------------------------------------TTQTAVSSARFGHWHKNKSP-TEYRSG-PRLIIFVIGGL SHSEMRSAYEVTR---ATDGKWEVLIGSS--------------HILTPTSFLNDLKSLDQV-------------PNPDC- ------------------------------------------------------------- >Oryzias_latipes_STXBP2_a ------------------------------------------------------------------------------MA PSGLKAVVGE-KILNGVIKSV--------------KKDGEWKVLIVDHMSMRILSSCCKMSDILAEGVT-IVEDINKCRE PISSLEAIYLISPMEK---------------------------SVKALINDFKDT---VFTYKAAHIFFTD--------- ---------------------------------------------ACSDSLFAEIGRSRVAKVIKTLKEINVAFLPYESQ VFSLDSPSSFKSFYGSRPC--ESKDRMIENMAEQIATLCDTLKEFPAVRYR-------KGPEENAKLAEEVSRRLT-AHK ADNPSMGEG-ADKARSQLLIVDRGFDPISPVLHELTFQAMAYDLLDIKQDIY---------------------------- -------------------------------------------------------------------------------- -----------TYQTTG-----VGNSKQREVLLDEDDELWVQLRHQHIADVTKKVTELLRSFCES---KRMCTD---NAN IKDLAQMLKKMPQYQKELTMYS----THLHLAEACMKTFKATLDKICEVEQ--DLAMGTNADGEPIKDPMKSIVPVLLNN DIGPFEKIRIILLFIFHK---KKGIGEENLTKLIEHANIKN-HSTIITNLQNLGCNII-----AGGRNTG---------- -------------------------NTLPVRKERT-ESTYQLSRWTPIIKDIMEDAIEDKLDTKQWPFFGDRA-----QI N----------------------------------------TTQTTVNSARFGHWHKNKSP-TEYRSG-PRLIIFVIGGV SHSEMRSAYEVTR---STDGKWEVLIGSS--------------HILTPNGFLNDLKSLDQD-------------SESTS- ------------------------------------------------------------- >Homo_sapiens_STXBP3 --------------------------------------------------------------------------MAPPVA ERGLKSVVWQ-KIKATVFDDC--------------KKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGIT-VVENIYKNRE PVRQMKALYFITPTSK---------------------------SVDCFLHDFASKSE--NKYKAAYIYFTD--------- ---------------------------------------------FCPDNLFNKIKAS-CSKSIRRCKEINISFIPHESQ VYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKP----LDN--ASKLAQLVEKKLEDYYK IDEKSLIKG---KTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKTDG---------KEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISST---KKATEG---KTS LSALTQLMKKMPHFRKQITKQ----VVHLNLAEDCMNKFKLNIEKLCKTEQ--DLALGTDAEGQKVKDSMRVLLPVLLNK NHDNCDKIRAILLYIFSIN----GTTEENLDRLIQNVKIEN-ESDMIRNWSYLGVPIV-----PQSQQGK---------- ----------------------------PLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCP--AVWNG S----------------------------------------GAVSAR------QKPRANYLE-DRKNG-SKLIVFVIGGI TYSEVRCAYEVS----QAHKSCEVIIGST--------------HVLTPKKLLDDIKMLNKPK-------------DKVSL IKDE--------------------------------------------------------- >Pan_troglodytes_STXBP3 --------------------------------------------------------------------------MAPPVA ERGLKSVVWQ-KIKATVFDDC--------------KKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGIT-VVENIYKNRE PVRQMKALYFITPTSK---------------------------SVDCFLHDFASKSE--NKYKAAYIYFTD--------- ---------------------------------------------FCPDNLFNKIKAS-CSKSIRRCKEINISFIPHESQ VYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKP----LDN--ASKLAQLVEKKLEDYYK IDEKSLIKG---KTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKTDG---------KEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISST---KKATEG---KTS LSALTQLMKKMPHFRKQITKQ----VVHLNLAEDCMNKFKLNIEKLCKTEQ--DLALGTDAEGQKVKDSMRVLLPVLLNK NHDNCDKIRAILLYIFSIN----GTTEENLDRLIQNVKIEN-ESDMIRNWSYLGVPIV-----PQSQQGK---------- ----------------------------PLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCP--AVWNG S----------------------------------------GAVSAR------QKPRANYLE-DRKNG-SKLIVFVIGGI TYSEMRCAYEVS----QAHKSCEVIIGST--------------HVLTPKKLLDDIKMLNKPK-------------DKVSL IKDE--------------------------------------------------------- >Callithrix_jacchus_STXBP3 --------------------------------------------------------------------------MAPPVA ERGLKSVVWQ-KIKATVFDDC--------------KKEGEWKIMLLDEFTTKLLASCCKMSDLLEEGIT-VVENIYKNRE PVRQMKALYFITPTSK---------------------------SVDCFLRDFGSKSE--NKYKTAYIYFTD--------- ---------------------------------------------FCPDNLFNKIKAS-CSKSIRRCKEINISFIPHESQ VYTLDVPDAFYYCYSPDPGNAKGKDAIMEAMADQIVTVCATLDENPGVRYKSKP----LDN--ASKLAQLVEKKLEDYYK IDEKSLIKG---KTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKTDG---------KEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISST---KKATEG---KTS LSALTQLMKKMPHFRKQITKQ----VVHLNLAEDCMNKFKLNIEKLCKTEQ--DLALGTDAEGQKVKDSMRVLLPVLLNK NHDNCDKIRAILLYIFSIN----GTTEENLDRLIQNVKIEN-DSDMIRNWSYLGVPIV-----PQSQQGK---------- ----------------------------PLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQYP--AVWNG S----------------------------------------GAVSAR------QKPRANYLE-DRRNG-SKLIVFVIGGI TYSEMRCAYEVS----QAHKSCEVIIGST--------------HILTPKKLLDDIKMLNKPK-------------DKISF IKDE--------------------------------------------------------- >Mus_musculus_STXBP3 --------------------------------------------------------------------------MAPPVS ERGLKSVVWR-KIKTAVFDDC--------------RKEGEWKIMLLDEFTTKLLSSCCKMTDLLEEGIT-VIENIYKNRE PVRQMKALYFISPTPK---------------------------SVDCFLRDFGSKSE--KKYKAAYIYFTD--------- ---------------------------------------------FCPDSLFNKIKAS-CSKSIRRCKEINISFIPQESQ VYTLDVPDAFYYCYSPDPSNASRKEVVMEAMAEQIVTVCATLDENPGVRYKSKP----LDN--ASKLAQLVEKKLEDYYK IDEKGLIKG---KTQSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKTDG---------KEKEAVLEEDDDLWVRVRHRHIAVVLEEIPKLMKEISST---KKATEG---KTS LSALTQLMKKMPHFRKQISKQ----VVHLNLAEDCMNKFKLNIEKLCKTEQ--DLALGTDAEGQRVKDSMLVLLPVLLNK NHDNCDKIRAVLLYIFGIN----GTTEENLDRLIHNVKIED-DSDMIRNWSHLGVPIV-----PPSQQAK---------- ----------------------------PLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSRCP--AVWNG S----------------------------------------GAVSAR------QKPRTNYLELDRKNG-SRLIIFVIGGI TYSEMRCAYEVS----QAHKSCEVIIGST--------------HILTPRKLLDDIKMLNKSK-------------DKVSF KDE---------------------------------------------------------- >Rattus_norvegicus_STXBP3 --------------------------------------------------------------------------MAPPVT ERGLKSVVWR-KIKTTVFDDC--------------RKEGEWKIMLLDDFTTRLLSSCCKMTDLLEEGVT-VIENIYKNRE PVRQMKALYFISPTPK---------------------------SVDCFLRDFGSKSE--KKYKAAYIYFTD--------- ---------------------------------------------FCPDSLFNKIKAS-CSKSIRRCKEINISFIPHESQ VYTLDVPDAFYYCYSPDPSNAGRKEAVMEAMAEQIVTVCATLDENPGVRYKSKP----LDN--ASKLAQLVEKKLEDYYK IDENGLIKG---KTQSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIEKDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKTDG---------KEKEAVLEEDDDLWVRVRHRHIAVVLEEIPKLMKEISST---KKATEG---KTS LSALTQLMKKMPHFRKQISKQ----VVHLNLAEDCMNKFKLNIEKLCKTEQ--DLALGTDAEGQRVKDSMLVLLPVLLNK NHDNCDKIRAVLLYIFGVN----GTTEENLDRLIHNVKIED-DSDMIRNWSHLGVPIV-----PPSQQAK---------- ----------------------------PPRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSRCP--AVWNG S----------------------------------------GAVSAR------QKPRTNYLELDRKNG-SRLIIFVIGGI TYSEMRCAYEVS----QAHKSCEVIIGST--------------HILTPRKLLDDIKMLNKSK-------------DKVSF LKDE--------------------------------------------------------- >Myotis_lucifugus_STXBP3 --------------------------------------------------------------------------MAPPET ERGLKSVVWQ-KIKATVFDDC--------------KKEDEWKIMLLDEFTTKLLASCCKMTDLLAEGIT-VVENIYKIRE PVRQMKALYFISPTSK---------------------------SVDCFLRDFPSKSE--SKYKAAYIYFTD--------- ---------------------------------------------FCPDSLFNKIKSS-CSKSIRRCKEINISFIPLESQ VYTLDVPDAFYYCYSPDPSNANGKDAVMEAMAEQIVTVCASLDENPGVRYKSKP----LNN--ASKLAQLVEKKLENYYK TDEKSLIKG---KTHSQLIIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKTDG---------KEKEAILEEDDDLWVRIRHRHIAVVLEEIPKLMKEISST---KKATEG---KTS LSALAQLMKKMPHFRKQITKQ----VVHLNIAEDCMSKFKSNIEKLCKTEQ--DLALGTDAEGQKVKDSMRVLLPVLLNK NHDNYDKIRAILLYIFSNN----GTTEENLDRLIQNVKIEN-ESDMIRNWSYLGVPIV-----PPSPQGK---------- ----------------------------PSRKDRSTEETFQLSRWTPYIKDILEDAIDNRLDSKEWPYCSQCP--AVWNG S----------------------------------------GAVSAR------QKPRGNYLE-DRKNG-STLIVFVIGGI TYSEMRCAYEVS----QAHKSCGVIIGST--------------HILTPKKLLDDIKMLNKSK-------------DKVSI MKDE--------------------------------------------------------- >Pteropus_vampyrus_STXBP3 --------------------------------------------------------------------------MAPPVT ERGLKSVVWQ-KIKSAVFDDC--------------KKEDEWKIMLLDEFTTKLLASCCKMTDLLAEGIT-VVENIYKNRE PVRQMKALYFISPTSK---------------------------SVDCFLRDFASKSE--NKYKAAYIYFTD--------- ---------------------------------------------FCPDSLFNKIKAS-CSKSIRRCKEINISFIPLESQ VYTLDVPDAFYYCYSPDPSNANGKDAIMEAMAEQIVTVCATLDENPGVRYRSKP----LDN--ASKLAQLVEKKLENYYK TDEKSLIKS---KTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKTDG---------KEKEAVLEEDDDLWVRIRHRHIAVVLEEIPKLMKEISST---KKATEG---KTS LSALAQLMKKMPHFRKQITKQ----VVHLNLAEDCMNKFKSNIEKLCKTEQ--DLALGTDAEGQKVKDSMRVLLPVLLNK NHDNYDKIRAILLYIFSIN----GTTEENLDRLIQNVKIEN-ESDMIRNWIYLGVPIV-----PPSQQSK---------- ----------------------------SLRKDRSAEETFQLSRWTPFIKDILEDAIDNRLDSKEWPYCSQCP--AVWNG S----------------------------------------GAVSAR------QKPRANYLE-DRKNG-SKLIVFVIGGI TYSEMRCAYEVS----QAHKSCEVIIGST--------------HILTPKKLLDDIKMLNKSK-------------DKISF IKDE--------------------------------------------------------- >Gallus_gallus_STXBP3 ----------------------------------------------------------------------------MAPT ARGLKSLVWQ-KLKSAVFDDC--------------RKEDEWKVILLDDYTTKLLSLCCKMTDLLAEGIT-VVENVYKNRE PVPHMKAIYFITPTKK---------------------------SVDGLIDDFISKSS--SRYKAAYVYFTD--------- ---------------------------------------------TCPDNLFNKIKSS-CARSIRRCKEISISFFPYESQ VFTLNVPDAFYCCYSPTLENSKDKDAVMEAMAEQIVTLCATLEENPGVRCKSTP----SDN--ASRLAQLVEKKLENYYK TDEQSQIKA---KTHSQLIIIDRGFDPVSTVLHELTFQAMAYDLLPIENETY---------------------------- -------------------------------------------------------------------------------- -----------K-YKAD--------GKDKEAILEEDDELWVKIRHKHIADVIEEISQLLKEVSSK---KKAAEG---KLT LSGLAHLMKKMPQYRKEITRQ----VVHLNIAEDCMSKFKANIERLCKTEQ--DLALGTDAEGQKVKDTMRVLLPVLLNK SHDSYDKIRAILLYIFSTN----GTTEENLDKLIQNVQIES-DSDMIRNWEYLHVPITN---SSAVQQQK---------- ----------------------------QPRRDRSSEETFQLSRWTPLIKDVMEDAIENKLDSKEWPYCSQCP--PTWNG S----------------------------------------GIVSAR------QKPKGSYQD-ERRSN-ARLIIFVIGGI TYSEMRSAYEVS----QTYKSCEVIVGST--------------HILTPRRLLDEVKSLNKPK-------------DTVCI KDE---------------------------------------------------------- >Taeniopygia_guttata_STXBP3 -------------------------------------------------------------------------------- ------------LKSAVFDDF--------------TKEEEWKVMLLDDYTTKLLSLCCKMSDLLAEGVT-VVENVYKTRE PVPNMKAIYLITPTKK---------------------------SVDGLIDDFINKSS--SRYKAAYVYFTD--------- ---------------------------------------------FCPDSLFNKIKAS-CAKSIKKCKEINISFFPYESQ VFTLNIPDAFYRCYSPTLEKTKDKDAVLQVMAEQIVTLCATLDENPGVRYKSGP----SDR--VSKLAQLVEKSLENYYK TDERSQIKA---KTHSQLIIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTY---------------------------- -------------------------------------------------------------------------------- -----------KQYCSG--------GKEKEAILEEDDDLWVKMRHKHIADVLEEIPKLLKDASSK---TKAAEG---KLS ISALSQLMKKMPLYRKEISKQ----VLHLNIAEDCMSKFKSNVERLCKTEQ--DLALGTDAEGEKVKDSMRVLLPVLLNK SHDSYDKIRAILLYIFSTN----GTTQENLDKLIQNVHIES-DSDMIKNWKYLDVPFV-------AQQHK---------- ----------------------------YVRRDRSKEETFQLSRWTPVIKDVMEDAIENKLDSKDWPYCSRCP--PTWNG S----------------------------------------GAVSAR------QKPRASCRE-ERRSG-ARLIVFVIGGV TYSEMRSAYEVT----EAYKSCEVVIGST--------------HILTPRKLLEEVKSLSKPK-------------DMVCI KDE---------------------------------------------------------- >Anolis_carolinensis_STXBP3 ---------------------------------------------------------------------MAPAAA-TASG ERGLKSLVWQ-KLKTSVFDDC--------------RKEEEWKIILLDDFTTKLLSSCGKMTDLLAEGIT-VVENVYKNRE PVPHMKAIYLITPTTQ---------------------------SVDGLINDFVSKSS--SKYKAAYVYFTD--------- ---------------------------------------------FCDDKLFNRMKSS-CSKAIRRCKEININFFPYESQ VFTLDVPNAFYHCYSPIVEKAN--ETVMEQIADQIVTLCATLEENPGVRYKSKP----LDN--ASKLAQLVEKKLENYYK MDERGKVKG---KTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKTEDAS------GKEREAILEEDDDLWVKIRHKHIADVLEEIPKLMKEVSSK---RKATEG---KQT LSNLAQLMKKMPYFRKQITKQ----VVHLNIAEDCMNKFKNNVEKLCKVEQ--DLALGADAEGQRVRDSMQVLLPVLLNK NHDSYDKIRAILLYIFSTN----GTTQETLDKLIQKVQIEN-DSDMIKNWKHFGVPILT---TSTSQQRK---------- ----------------------------SSRRNRSSEETYQLSRWTPMIKDVMEDTIENKLDSKEWPYCSQCP--APWNG S----------------------------------------GAVSAR------NKPKTSHLD-ERKSG-SKLIVFVIGGI TYSEMRCAYEVS----QAYKSCEVIIGST--------------HIITPRRLLDDIKALTVPKSK-----------DTVYF KNE---------------------------------------------------------- >Pelodiscus_sinensis_STXBP3 ------------------------------------------------------------MSEVEWGSKMAPAAVGAASG ERGLKSLVWQ-KLKSSVFDDC--------------WKTNEWKIIILDDFTTKLLSSCGKMTDLLAEGIT-AVENVYKKRE PVPHMKAIYLITPTEK---------------------------SVDGLISDFVTKSS--YKYKAAYVYFTD--------- ---------------------------------------------FCPDSLFNKMKSC-CSKVIRRCKEINISFFPYESQ VFTLDVPDAFFCCYSPTMEKANGKDAVMEAMAEQIVTLCATLDENPGVRYKSQP----LVN--AIKLAKLVENKLENYYK MDERSQIKG---KTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTY---------------------------- -------------------------------------------------------------------------------- -----------KYTTDGPN------GKEKEAILEEEDELWVRIRHKHIADVLEEIPKLLKDVSSK---RKATEG---KLS LSNLAQLMKKMPHFRKQITKQ----VVHLNIAEDCMSKFKSSIEKLCKTEQ--DLALGTDAEGQKVKDSMRVLLPVLLSK NHDSYDKIRAILLYIFSTN----GTTQENLDKLIQNVQIES-DSDMIKNWKYLGVPVVV---SSAAQQRR---------- ----------------------------QSRKDRSSEETFQLSRWTPVIKDVMEDAIENKLDSKEWPYCSECP--AAWNG S----------------------------------------GAVSAR------QKPKTSYQD-ERKSG-SKLIVFVIGGI TYSEIRSAYEVS----QAYKSCEVIIGST--------------HILTPKRLLDDVKMLNKPK-------------DTICI KDEEKQKRERLSETDSVLDLNIDASEAKAVHK----------------------------- >Xenopus_tropicalis_STXBP3 ---------------------------------------------------------------------------MATGT DFGLKSTVWQ-KIKTEVLDDC--------------RKGDEWKILLLDHFTTKLLTSCCKMTDLLQEGIT-VVEDLFKKRQ PVEHMKAIYFISPNEK---------------------------SVDCLVNDFNSKSA--SKYKAAYVYFSD--------- ---------------------------------------------VCPDSLFNKLKSC-HPKTIKRCKEISISFFPKESQ VFLLNVPKAFHLLYSPD--KAVDKETAIQTIAQQIVTLCATLEENPGVRYKKEP----LDN--AEELANLVEEQLVQYYK MDEKDQFKA---KTQSQLLIVDRGFDPFSTILHELTFQAMVYDLLPIENDIY---------------------------- -------------------------------------------------------------------------------- -----------KYRTES-AL-----AKDKEARLDESDELWVKIRHKHIANVLEEIPKLVKEISSS---KKETEG---NIS ISKLADIMKKMPHIRKQIGKQ----TLHLSLAEDCMQKFRGRLEKLCKAEQ--DLALGSDAEGQKVKDHMRVLLPILISN DLDNYDKIRAILLYIFVEN----GTSQENLDRLITHAKIEG-GGDVLKNWKYLGVPIV-----PKSTQRR---------- ----------------------------PARRDRSKEETFQLSRWTPIIKDVIEDTMENKLDSKEWPYCSECP--AAWNG S----------------------------------------GAVSAR------QKHNTISRD-ERKNV-SRLIIFVIGGI TYSEIRCAYEVS----QANKFVQVIIGST--------------HIITPKTMLDDVKNLTKEA---------------VIP TND---------------------------------------------------------- >Danio_rerio_STXBP3_a ---------------------------------------------------------------------------MATGA DHGLKKIVWQ-RIRDTIIADC--------------KKWN---ILILDDFTTRLLSSCCKMSDLMSEGIS-VLENLFKNRE PVPDMKAIYFMAPTVE---------------------------CIDAFINDFKPKP----KYKAAYVFFTD--------- ---------------------------------------------YCPDELFDKMKKN-CAKHIKKCKEINISFLPQEAQ VFTCENPEAFKKIYSGF---SQDREKTLDKIADQIVTLCATLDEYPGVRYKREST---PGY--GKMLAELVDNKLARHYE LDEITTKKE---KTPAQLLIVDRAMDPVSPILHELTYQAMAYDLIPINNNIY---------------------------- -------------------------------------------------------------------------------- -----------EYKMKD--------GSKKEALLNEDDELWVKLRHRHIAEVTEQIPKLVKDISASRDEKQQGDG---KIT IGALSQLMKKMPAFRKQVTQK----TVHLHLAEDLMGHYQKNVEKLCKAEQ--DLAVGADAEGQKVKDPMRTLLPVLLHQ -HDTTDKIRAVLLYIFSLN----GTTTENLNKLIQNVKIED-KDGYIQNWNQLGVPIL----SSSNSSRK---------- ----------------------------VARRDRSEQETYNVSRWTPVIKDIMEDAVENKLDIKDWPFQSECP--SAWNG S----------------------------------------RAVRVLSAR---QKHKGSSPG-DMKNG-SRLIIFVLGGV SYSEMRCAYEVT----NTNKSCEVIIGST--------------HILTPRSLLEDIYNLGKKP--------------MDTL TIEEGKV------------------------------------------------------ >Takifugu_rubripes_STXBP3_a ------------------------------------------------------------------------------VT DYGLRKVVWK-KIKDTIIADC--------------SKSEVWKIMILDPFTTKLLSSCCKMSDLMAEKIT-IVEDLFKSRE PVPEMKAIYFMSPTAK---------------------------CVESFIADFKTNP----KYKAAYVYFTD--------- ---------------------------------------------YCPDDLFNNMKLY-CSKYIRVCKEINMNFMPLEAQ VFSCDNPGAFKSIYSPK---SQDKQKTLEELADQLVTLCATLDEYPGVRYKKESN---MEN--TKIFAELVDKKLARHYE LDDSGTKKG---KTQAQLLILERGFDPVSPLLHELTYQAMAYDLIDIQNDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKSKD--------GLEKQAILNEDDMLWVKLRHKHIAEVSEQIPKMVKEISAS---KKQPDE---KIT IRNLAQMMKKMPSIRKQLTEK----TAHLQLAEDCMQCFSNNVEKLCKAEQ--DLAVGSDVDGQKVKDPMRTLLPVLLHP -YSTQDKIRAVLLYIFSLG----GTTDENLSKLIQHVKIED-EREFILNWKELGVPII---TAPSFFSRK---------- ----------------------------SSRRDRSQDETYNLSRWTPVIKDVMEDAVENKLDAKDWPHQSECP--AAWNG S----------------------------------------GAVRYTRFPPKIQKSK-TTQD-ERRSG-SRLIIFVLGGI CFSEMRSAYEVN----QAVKSCEVIIGSS--------------HILTPTSLLNDIKALSKGP--------------METF TIE---------------------------------------------------------- >Tetraodon_nigroviridis_STXBP3_a ---------------------------------------------------------------------------MAAST DHGLRKIVWK-RIKDTIITDC--------------RKSEVWKIMILDPFTTKLLSSCCKMSDLMAEKIT-IVEDLFKSRE PVPEMKAIYFMSPTAK---------------------------CVDSFIADFKTNP----KYKAAYVYFTD--------- ---------------------------------------------YCPDDLFNNMKLY-CSKYIRVCKEININFMPLEAQ VFTCDSPEAFQSIYSPR---SQDKEKTRRDWQTNSLKIIRTYYEYSFHKFKKKWG---GAS--KNTKLPPFSAISFATFC L------QG---KTQAQLLILERGFDPVSPLLHELTYQAMVYDLIDIQNDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKSKD--------GSEKQAVLNEEDMLWVRLRHKHIAEVSEQIPKMVKEISAS---KKQPDG---KIT IRNLAEMMKKMPSIRKQLTEK----TAHLQLAEDCMQCFSNNVEKLCKAEQ--DLAVGSDVEGLKVKDPMRTLLPVLLYP -YSTQDKIRAVLLYIFSLG----GTTDENLSKLIQHLLLGF-ISELAGDYFSS--------LQPSLFTRK---------- ----------------------------PSRRDRSQEETYNLSRWTPVIKDVMEDAVENKLDTKDWPHQSECP--AAWNG S----------------------------------------GAVSAR------QKSK-ITQE-ERRSG-SRLIVFVLGGI CFSEMRSAYEVN----QAVKSCEVIIGSS--------------HILTPTSLLNDIKALSKGP--------------METF TIEERSNA----------------------------------------------------- >Gasterosteus_aculeatus_STXBP3_a --------------------------------------------------------------------------LIELKN DIKLTNLLLC-QNEKNSMSNR--------------KTS----ILILDPFTTKLLSTCCKMSDLMLEKIT-IVEDLYKKRE PVPEMKAIYFMSPTTT---------------------------CVDAFIADFKPKP----KYKAAYVYFTD--------- ---------------------------------------------YCPDDLFNNMKRS-CATYIRVCKEINLSFMPQEAQ VSVF--------IYSPH---SRDKTKTLETLADQLVTLCATLDEYPGIRYKKHYE---LEEDSKKKVRHPLDKIFN---- ------HKE---KTQAQLLIVDRGFDPVSPILHELTYQAMAYDLIDIQSDTY---------------------------- -------------------------------------------------------------------------------- -----------KYKAKD--------KSEKQALLNEDDLLWVKLRHKHIADVSELIRKLVKEISAN---KKQPDA---KIT ISSLAEMMKKMPSFRKQVTEK----TIHLQLAEDCMHHFSNNVEKLCKAEQ--DLALGSDVEGVKVKDSMRTLLPVLLHP -YSTHDKIRAVLLYIFSVNA---GTTEENLNKLIQHVKIEE-DQEFILNCLRFLVAEC----TQSFFSRK---------- ----------------------------TSRRNRSQDETYNLSRWTPVIKDVMEDAVENKLDTKEWPHQSECP--AAWNG S----------------------------------------GAVRYK------QKNS--AAD-ERRTG-SRLIVFVLGGI SHSEMRCAYEVT----QAVKSCEVIIGSS--------------HILTPTSLLNDIKTLSKAP--------------METF TIEEKA------------------------------------------------------- >Oryzias_latipes_STXBP3_a ---------------------------------------------------------------------------MAAGS DHGLKKIVWK-RIKDTIITDC--------------RKSEVWKILILDPFTTKLLSSCCKMSDLMAEKIT-IVEDLFKKRE PVLEMKAIYFMTPTAK---------------------------CVEAFLGDFEKKP----KYKAAYVYFTD--------- ---------------------------------------------YCPDDLFNKMKSR-CGKFIRVFKEINMSFLPQEAQ VFTCNNPEAFRSIYSPH---SQDKMSTLETLADQIVTLCATLDEYPGVRYKKESN---MEN--AKTLAELVDNKLAKHYE LDDSDKKKG---KTQAQLLIVERGFDPVSPILHELSYQAMAYDLIDIQDDTF---------------------------- -------------------------------------------------------------------------------- -----------RYKLKD--------GSEKQALLTEDDMLWVKLRHKHIAEVSAEIPKMVKEISAS---KQQPDE---KIT ISKLAQMMKKMPSFRKQLNEK----TTHLQLAEECMQHFSNNVEKLCKAEQ--DLAVGSDADGAKVKDSMRTLLPVLLHP -YSTYDKIRAVLLYIFSVN----GTTDENLNKLIQHVKIED-EREFILNWKELGVPIITFPTQSSFFSRK---------- ----------------------------PTRRDRSQEEKYNLSRWTPVIKDVMEDAVENKLDTKEWPHLSESP--AAWNG S----------------------------------------GAVSAR------QKHKPSAQD-ERRTG-SRLIIFVIGGI TYSEMRCAYEVT----QAVKSCEVIVGSS--------------HILTPTSLLDDIKALSKTS--------------MKTN FKEL---------------------------------------------------------