>Homo_sapiens_SH2D3A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MQVP-QDGED----------LAGQPWYHGLLSR--- QKAEALLQQNGDFLVRASGS----RGGNPVISCRWRGS-ALHFEVFRVALRPR---PGRPT-ALFQLEDEQFPSIPALVH SYMTGRRPLSQATGAVVSRPVTWQGP----------LRRS-------FSEDTLMDGPA---------------------- -------------RIEPLRARK--------------------------WSNSQP--------------ADLAHMGRSR-- ------------------------------EDPAGMEAS----------------TMPISALPRTSSDPVLLKAPAPLGT -----VADSLRASDGQLQAKAPTKPPRTPSFELP-------------------DASERPPTYCELVP------------- ------------RVPSVQGT-------------SPSQSCPE---------------------PEAPWWEAEEDEEEE--- ----NRCFTRPQAEIS-FCPHD-APSCLLGP-QNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLG-VTRDQR GNM---------GVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDL PGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAG---PCDPGEVALPHVAPMVRLLEG---- ----------------------EEVAGPLDESCERLLRTLHGAR-HMVRDAPKFRKVAAQRLRG-F-RPNPELREALTTG FVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Pan_troglodytes_SH2D3A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MQVP-QDGED----------LAGQPWYHGLLSR--- QKAEALLQQDGDFLVRASGS----RGGNPVISCCWRGS-ALHFEVFRVALRPR---PGRPT-ALFQLEDEQFPSIPALVH SYMTGRRPLSQATGAVVSRPVTWQGP----------LRRS-------FSEDTLMDGPA---------------------- -------------RIEPLRARK--------------------------WSNSQP--------------ADLAHMGRSR-- ------------------------------EDPPGMEAS----------------TMPISALPRTSSDPVLLKAPAPLGT -----VADSLRASDGQLQAKAPTKPPRTPSFELP-------------------DASERPPTYCELVP------------- ------------RVPSVQGT-------------SPSQSCPE---------------------PEAPWWEAEEDEEEE--- ----NRCFTRPQAEIS-FCPHD-APSCLLGP-QNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLG-VTRDQR GNM---------GVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDL PGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAG---PCDPGEVALPHVAPMVRLLEG---- ----------------------EEVAGPLDESCERLLRTLHGAR-HMVRDAPKFRKVAAQRLRG-F-RPNPELREALTTG FVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Macaca_mulatta_SH2D3A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------EAF----------------ATPVSALPRTGSDPVLLKAPAPLGT -----VANSLRASDGQLQAKAPAKPPRTPSFELP-------------------DASERPPTYCELVP------------- ------------RVPCVQGT-------------SLSQSCPE---------------------PEAPWWEAEEDEEEE--- ----NRCFTRPQAEIS-FCPPD-TPSCLLGP-QNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLG-VTRVQR DNM---------GVSSGLELLTLPHGCRLRLELLERHETLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDL PGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGVG---PCDPGEVALPHVAPTVRLLEG---- ----------------------EEVAGPLDESCERLLRTLHGAR-HMARDAPKFRKVAAQRLRG-F-RPNPELREALTTG FLRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDS------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Callithrix_jacchus_SH2D3A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MQVP-QDGED----------LAGQPWYHGPLSR--- QKAEALQQ-DGDFLVRASGS----RGGHPVISCRWRGS-ALHFEVFRVALRPR---PGRPT-ALFQLEDEQFPSMPALVH SYLTGKRPLSQATGAVVSRPVTRPGP----------LRRS-------FSEDTLMDGPA---------------------- -------------RTEPLRVRK--------------------------WSSSQP--------------ADLAHIGRSR-- ------------------------------EDPPGMGAS----------------TMPVSALLRSGSEPVLLKAPASLGT -----INNSLRGSDGQLQAKAPTKPPRTPSLELP-------------------DVPERPPTYCELVP------------- ------------RVPSVQGT-------------SPSQSRQE---------------------TEVPWWEAEEDEEEE--- ----NRCFTRPQAEIA-FCPPD-APSCLLGP-QNRPLEPQVLRTLRDLFLEHHPGSTALHLLLVDCQATGLLG-VTRDQR GNM---------GVSSGLELLTLPHGHRLRSELLERHETLTLAGALAVLGCSGPLEERAAAVRGLVELALALRPGAAGDL PGLAAVMGALLMPQVSRLEHTWRHLRRSHTEAALAFEQELKPLMRALDEGAG---PCDPGEVALPHVAPVVRLLEGG--- ----------------------EEVAGPLEESGERLLRTLHGAR-QMARLAPKFRKVAAQRLRG-F-RPNPELSEALTTG FLRRLLWGSRGAGAPHAERFEKFQRVLGVLSLRLEPDR------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Canis_familiaris_SH2D3A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MQVP-QDGED----------FASQPWYHGPLSR--- QKAEALLQQDGDFLVRASRS----RGGHPVISCRWQGS-ALHFEVLRVALRPR---PGRPT-ALFQLEDERFPSLPSLVL SYVTGQRPLSQATGAVASRPVIRQGP----------IRRS-------FSEDTLLESPA---------------------- -------------RIELPRARK--------------------------RSDSQP--------------AGLEHMGLSG-- ------------------------------EDHSGPGAS----------------PVPTCALPRMGSDPVLLKTPASLGS -----VVDGLRASDGQLHAKAPNKPPRTPSLVLH-------------------DASGRPPTYCELVP------------- ------------RVPSAQET-------------PTGHSGPE---------------------TEASWWEANEEEEEE--- ----DRSFARPKAEVF-FCPPN-NLFCLLGP-QNRPLEPKVLSTLRDLFLEHHPGSTALHLLLVDCQATGLLG-VTKAQR GAM---------GVTSGLELLTLPHGHRLRLELLERHEALALAGALAVLGCSGPLEERAATLRGLVELALALRPGAAGDL PGLAAVMGALLMPQVSRLERTWRQLRRSHTQAALAFEQELKPLMRALDEGAG---PCAPGEVALPHVVPAVRLLEG---- ----------------------QELPGPLDESCERLLRTLHRAR-LVARDAPQFREAAARRLRG-F-QPNPQLREALTTG FVQRLLWGSQGVGAPHATRLEKFQRVLSALSQRLEPDV------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Felis_catus_SH2D3A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MQVP-QDGED----------FASQPWYHGPLSR--- QKAEALLQQDGDFLVRASGS----RGGHPVISCRWQGS-ALHFEVLRVALRPR---PGRPT-ALFQLEDERFPSLTSLVL SYVTGQRPLSQATGAVASRPVIRQGP----------IRRS-------FSEDTLRGSPA---------------------- -------------LTELPRTRK--------------------------WSDSQP--------------AGLEHMGRSR-- ------------------------------EDHCGPEAS----------------AMPLCALPRTGSDPVLLKTPAPLGS -----VADSLRASDGQLHAKAPTKPPRTPSLVLR-------------------DASGRPPTYCELVP------------- ------------RVPSAQGT-------------PPGHSSPE---------------------TEAPWWEAEEEEEEE--- ----SRSFARPQAEVS-FCPPN-NPSCLLGP-QNRPLEPRVLSTLRGLFLEHHPGSTALHLLLVDCQATGLLG-VTKAQR GAM---------GVASGLELLTLPHGHRLRLELLERHEALALAGALAVLGCAGPLEERAATLRGLVELALALGPGAAGDL PGLAAVMGALLMPQVSRLERTWRQLRRSHTEAALAFEQELKPLMRALDEGAG---PCDPGEVALPHVVPAVRLLEG---- ----------------------EELPGPLDESCERLLRTLHRAR-QMAQDAPKFREAAARRLRG-F-HPNPQLREALTTG FVQRLLWGSRGVGAPQAARLEKFQRVLSVLSQRLEPDG------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Bos_taurus_SH2D3A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MQVP-QDGED----------FVGQPWYHGPLSR--- QKAEDLLQQDGDFLVRASKS----RGGHPVISCRWRGS-ALHFEVLRVALRPR---PGRPT-ALFQLEDERFPSLPALVR SYVIGQRPLSQATGAVASRPVPRQGL----------IRRS-------FSEDTLPDDPA---------------------- -------------RTEPLRDRK--------------------------RSDSQP--------------AGLEHMWRSP-- ------------------------------EDPPGPGAS----------------TVPASGLPRTGSDPVILKTPVPLGS -----VADSLRASDGQLHAKAPTKPPRTPSLLLP-------------------DASGRPPTYCELVP------------- ------------RVLRFQGP-------------PPGHSCPE---------------------SEVPWWEAEEEKEE---- ----DRCFARPQAEVS-FCLPD-TPSCLLGS-QNRPLEPEVLHTLRGLFLEHHPGSTALHLLLVDCQATGVLG-VTKAQR GAM---------GVASGLELLTLPHGHRLRLELLERLETLALAGALAVLGCAGPLEERAAALRGLVELAVALRPGAVGDL PGLAAVMGALLMPQVSRLERTWRHLRRSHTEAALAFEQELKPLMRSLNEGAG---PSDPGEVALPHVAPAARLLEG---- ----------------------EELPGPLDESCERLLRTLHRAR-QTARDAPRFREAVARRLRG---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Pteropus_vampyrus_SH2D3A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MQVP-QDGED----------FASQPWYHGPLSR--- QKAEALLRQDGDFLVRASES----HGGHPVISCRWQGL-ALHFEVLCVALRPR---PGRPA-ALFQLEDERFPSLHALVH SYVSGQRPLTQATGAVASRPVTRQEP----------IRCS-------FSEDTLLDSPA---------------------- -------------RVKLLRGRK--------------------------WSDSQP--------------AGLELVGQSR-- ------------------------------EGHSGPGAS----------------AVPTFALRRMGSDPVLLKTSDPLGS -----IADSLWASDGQLHTKMPTKPPRTPPLVLP-------------------DASGRPPTYCELVL------------- ------------RVSSARGT-------------PSGHSCPE---------------------PETPWWETQEEVEDE--- -----RCFARPQAQVS-FCPAD-NPSSLLGP-QNRPLEPKVLHILRGLFLEHHPASTACHLLLADCQATGLLG-VTKAQR DAM---------GVASGLELLTLPHGHCLRSELLERHEALVLAGALAVLGCSGPLEERAAALRGLVELALELRPGAAGDL PGLAAVMGALLMPQVSRLERTWRQLRRSHTEAALAFEQELKPLMRALDEGAG---PCDPGEVALPHVAPAVRLLEG---- ----------------------EEILGPLDESCEQLL--------HVARDAPKFREAAARRLRG-F-RPNPELSEALTTG FMRRLLWGSRGEGAPRAARLEKFQLVLSVLSHRLEPDH------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Takifugu_rubripes_SH2D3A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------MDA-----------LKKELEEELK-LSSED----------LKSHAWYHGPLGR--- EAGEALLERDGDFLVRDSSS----APGDYVLTCFWMNG-PMHFKIIR-VVLRP---KQGYSRELFQFEEDRFDNVPALIR FHVGSRRPISQASSAVIFHPITRTLPLRVIREQQAG------------AGSGKQAK----SSKRR-------SLSTAH-- --------------ADMLQIINP-------------------------LLRSG------------SQPANLENVGRRP-- -------------------------SLQSAQSDSNIRTGTILTTVTR---AQDPGPAPISPVFRTGSEPLLSP--QHTRP SLPGV-GVTLQGSDGQLHPRAPPKPLRISAVFPN-----------AVIPPPIQRDEDPSSFYDELVVQYHSLCLSK-TK- --IPQAKQKGHVDRLRAEEKWQSRAR------LTETSFGFLEAS--SQL----------------PVIPQKKMADKV--- ---EDCHFQKPQVETGSCFQLDRFDSLLLPQ-NNRPLEPSVLLALKELFNRSNANTTALHMLSVDCQVARITGVTEEQKT -LM---------GVESGLELVTLPHGQQLRQDLLERHHLISLGVAVDILGCTGTVSQRAAVLHKIILLAQALKE-HTHNL YSFSAVMKALEMHQITRLEMTWRALRQNHTEMAVLFEKTLKPFMKLLNEGND---SVVDGPVAVPHLVPLLMAM------ --------------------EGDDPVENSERGCQLLYNILQSAR-NAAVRAQEYQEHAHSLLTG-W-VPVPELLEAFQTE FALRLLWGQSGAAGDKRERYEKFDKVLSVLSNKLEPVEHNPDTC------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Tetraodon_nigroviridis_SH2D3A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------LKKELEEELK-LSSED----------LSSHAWYHGPLRR--- EAAEALLERNGDFLVRDSSS----TPRDYVLTCFWMNM-PMHFKIIR-VVLRP---KKGYSRELFQFEEDRFDNIPALIR LYVGGRRPISQASGAVISHPITRTLPLRVIREQQAVPDSK-------GAGSDKEAK----SSKRR-------SLST---- --------------ADTLQVINP-------------------------LLRSGEACRNAYKYRSGSQPANLENVGRRP-- -------------------------SLQSAQSDSNIRTGT--PQITR---AEEPGPVPMSPVFRTGSEPMLSP--RHTRP SLPGG-GVTLRGSDGQLHPRAPPKPLRVSAVFPN-----------AVIPPPLQRKEDPSSFYDELVVQYHSLCLYK-QRG LPVPQARHKSHVDRLRAEEKWQSRAR------LTETSFGFLEAS--SQP----------------PLIPQK-TEQKV--- ---EDWHFQKPHVELESCFQLDRFDSLLLPQ-NNRPLEPSVLLVLKELFNRSNANATALHMLSVDCQVVRITQVTEEQKT -IM---------GVESGLELITLPHGRQLRLDLLERHHLLALGVAVDILGCTGTVSQRAAVLHKIILLAQALKE-HAHDL YSFSAVMKALEMPQVARLEMTWRALRQNHTEMAVLFEKTLKPFMNLLNEGDN---AAFDGPVAVPHLVPLLMAM------ --------------------EGDDPVENSERGCQLLYNILQCAR-NTAVHAHDYQQHANSLLTG-W-VPVPELLEVFRTE FALRLLWGQSGAAGDKRERYEKFDKVLTVLSNKLEPVEIRTTQA------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Drosophila_melanogaster_SH2D3A ----------------------------------------------------------------------MGNTQARQLE NRQVPNRRSSILWNFRYSNTVRRREDLAVMVHNS-RMSISEWLDLLELQQYEGNLQEFSTVDDVVDITDKELKQFGVRG- AHRQRMVNSLLGVRAKRRQSMNLEAMSSA--------------------------------------------------- --------------PRAVPRRKNSCPLVYLGENPQDMAGSGDSGPGVITTKSGKVLKQLTFDETSTIYEELRPRSKCNS- PHWAIEDSRMEG-YGSSNATTPLATAQPSPSEQQEAIALKKALEWELS-LDARE----------LRSHAWYHGALPR--- QRAEEIVQREGDFLVRDCAS----QPDNYVLSCRSKAA-VLHFVLNK-LVLQP---ETVYERVQYQFEEDAFDTVPDLIT FYVGSGKPISSASGALIQFPCNRTYPLSFYGHKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFEPQQQQQ QQLSPMAGSPASPHCSPPRARREVPP-------------------PPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQL- ------------------------QMQELENGNGNGIMR-----FQTIARCNPTSEQHLESKFTTHSLPRPN--TSAAHA LRQQAVARISSLARN--CSLDSPSDSRPPSPPPK-------------------PRKEPMAAVLAYQASGSDSG------- ----NGSGD-----SALGDACEASVQR---GVIIKNPRFMTTS---------------------VSNGTLKSFTEFDVLA AEEELFTMAIEEVKTASKFDFENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRIDIALFLEEPSNEEDYY ------------LSCSGLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDLDR-AQLLSKWIQIAVETKT-ALGNL FGFCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEASN----PQAPNTTVPHVLLYALLIDRPVMD IINHSNIDDR---PALYHTCIAPWESKADDFGMTINFQHLDASR-GFLKNLELYRKNAKIILEDASPRLDELLADAFRTE FHVKFLWGSSGATAKAEDRHNKLEKVLTLMADKFCMMAEQ---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Homo_sapiens_BCAR3 ------------------------------------------------------------------------MAAGKFAS LPRNM--PV--NHQFPLASSMDLLSSRSPL-AEHRPD-----------AYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGT LPHSKSPRQNSPVTQDGIQESPW--------------------------------------------------------- ----------------------------------------------------------------------QDRHGETFTF RDPHLLDPTV---EYVKFSKERHIMD------RTPEK-LKKELEEELL-LSSED----------LRSHAWYHGRIPR--- QVSENLVQRDGDFLVRDSLS----SPGNFVLTCQWKNL-AQHFKINR-TVLRL---SEAYSRVQYQFEMESFDSIPGLVR CYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTS-PG-------QAREGSLTKGRPDVAKRL-------SLTMGG-- -----------VQAREQNLPRGN-------------------------LLRNKEK--------SGSQPACLDHMQDRRA- ------------------------LSLKAHQSESYLPIGCKLPPQSS---GVDTSPCPNSPVFRTGSEPALSPAVVRRVS SDARA-GEALRGSDSQLCPKPPPKPCKVPFLKV---------------PSSPSAWLNSEANYCELNPAFATGC----GRG AKLPSCAQGSHTELLTAKQNEAPGPR------NSGVNYLILDD-DDRER----------------PWEPAAAQMEKG--- -QWDKGEFVTPLLETVSSFRPNEFESKFLPP-ENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRR -NM---------GVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKD-SMGDL YSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRE-STCVPPNNVSVPLLMPLVTLMERQ--- ----------------AVTFEGTDMWEKNDQSCEIMLNHLATAR-FMAEAADSYRMNAERILAG-F-QPDEEMNEICKTE FQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Pan_troglodytes_BCAR3 ------------------------------------------------------------------------MAAGKFAS LPRNM--PV--NHQFPLASSMDLLSSRSPL-AEHHPD-----------AYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGT LPHSKSPRQNSPVTQDGIQESPW--------------------------------------------------------- ----------------------------------------------------------------------QDRHGETFTF RDPHLLDPTV---EYVKFSKERHIMD------RTPEK-LKKELEEELL-LSSED----------LRSHAWYHGRIPR--- QVSENLVQRDGDFLVRDSLS----SPGNFVLTCQWKNL-AQHFKISR-TVLRL---SEAYSRVQYQFEMESFDSIPGLVR CYVGNRRPISQQSGAIIFQPINRTVPLRCLEERYGTS-PG-------QAREGSLTEGRPDVAKRL-------SLTMGG-- -----------VQAREQNLPRGN-------------------------LLRNKEK--------SGSQPACLDHMQDRRA- ------------------------LSLKAHQSESYLPIGCKLPPQSS---GVDTSPCPNSPVFRTGSEPALSPAVVRRVS SDARA-GEALRGSDSQLCPKPPPKPCKVPFLKV---------------PSSPSAWLNSEANYCELNPAFATGC----GRG AKLPSCAQGSHTELLTAKQNGAPGPR------NSGVNYLILDD-DDRER----------------PWEPAAAQMEKG--- -QWDKGEFVTPLLETVSSFRPNEFESKFLPP-ENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILEVSEEMRR -NM---------GVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKD-SMGDL YSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRE-STCVPPNNVSVPLLMPLVTLMERQ--- ----------------AVTFEGTDMWEKNDQSCEIMLNHLATAR-FMAEAADSYRMNAERILAG-F-QPDEEMNEICKTE FQMRLLWGSKGAQVNQTDRYEKFNQILTALSRKLEPPPAKQAEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Macaca_mulatta_BCAR3 ------------------------------------------------------------------------MAAGKFAS LPRNM--PV--NHQFPLASSMDLLSSKSPL-TEHRPD-----------AYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGT LPHSKSPRQNSPVTQDSIQESPW--------------------------------------------------------- ----------------------------------------------------------------------QDRHCETFTF RDPHLLDPTL---EYVKFSKERHIMD------RTPEK-LKKELEEELL-LSSED----------LRSHAWYHGRIPR--- QVSENLVQRDGDFLVRDSLS----SPGNFVLTCQWKNL-AQHFKINR-TVLRL---SEAYSRVQYQFEMESFDSIPGLVR CYVGNRRPISQQSGAIIFQPINRTVPLRCLEERYGIS-PG-------QAREGSLTEGRPDVTKRL-------SLTMGG-- -----------VQAREQNLPRGN-------------------------LLRNKEK--------SGSQPACLDHMQDRRA- ------------------------LSLKAHQSESYLPIGCKLPPQSS---GVDTSPCPNSPVFRTGSEPALSPAVVRRVS SDARA-GEALRGSDSQLCPKPPPKPCKVPFLKA---------------PSSPSAWLNSEANYCELNPAFAT------GRG AKLPLCAQGSPTELLTAKQNGALGPR------NSGINYLILDD-DDRER----------------PWEPAAAQTEKG--- -QWDKGEFVAPLLETVSSFRPNDFESKFLPP-ENKPLETAMLKRAKELFTNNDPKVIAQHILSMDCRVARILEVSEEMRR -NM---------GVSSGLELITLPHGHQLRLDIIERHSTMAIGIAVYILGCTGTLEDRAATLSKVIQVAVELKD-SMGDL YSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKILHEGRE-STCVPPNNVSVPLLMPLVTLMERQ--- ----------------AVIFEGTDMWEKNDQSCEIMLNHLATAR-LMAEATDSYRINAERILAG-F-QPDEEMNEICKTE FQMRLLWGSKGAQVNQAERYEKFNQILTALSRKLEPPPVKQAEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Callithrix_jacchus_BCAR3 ------------------------------------------------------------------------MAAGKFAS LPRNM--PV--NHQFPLASSMDLLSSKSSL-TEHRTD-----------AYQDVSIHSTLPRKKKGPPPIRSCDDFSHMGT LPHSKSPRQNSPLTQDGIQESPR--------------------------------------------------------- ----------------------------------------------------------------------QDRQGETFTF RDPHLLDPTL---EYVKFSKERHMMD------RTPER-LKKELEEELL-LSSED----------LRSHAWYHGRIPR--- QVSENLVQRDGDFLVRDSLS----SPGNFVLTCQWKNL-AQHFKINR-TVLRL---SEAYSRVQYQFEMESFDSIPGLVR CYVGNRRPISQHSGAIIFQPINRTVPLRCLEERYGTS-SG-------RAQEGSLTEGRPDVAKRL-------SLTMGG-- -----------VQTREQNLPRGN-------------------------LLRNKEK--------SGSQPACLDHMQDRRA- ------------------------LSLKAHQSESYLPIGCKLPPQSS---GVDTSPCPNSPVFRTGSEPALSPAVVRRVS SDARA-GEALRGSDSQLCPKPPPKPCKVPLLKA---------------PSSPSAWLNSEANYCELNPAFATGC----SRA AKLPLCAQGSRTELLTARQNGVPGPR------NSGINYLILDG-DDRER----------------PWEPVATQMEEG--- -QWDKGKFVTPLLETVSSFRPNDFESKLLPP-ENKPLETAMLKRAKEVFTNSNPKIIAQHILSMDCKVARILEVSEEMKR -NM---------GVSSGLELITLPHGHQLRLDIIERHNTMAMGIAVDILGCTSTLDERAATLSKIIQVAVELKD-SMGDL YSFSALMKALEMPQITRLEKMWTALRHQYTQTAILYEKQLKPFSKILHEGRE-STCVPPSNVSVPLLMPLVTLMERQ--- ----------------AVTFEGTDMWEKNDQSCEIMLNHLATAR-FMAQTADSYRMNAEMNLAG-F-QPDEEMNEICKTE FQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Mus_musculus_BCAR3 ------------------------------------------------------------------------MAAGKFAS LPRNM--PV--NHQFPLASSMDLLSSKSPL-AERRTD-----------AYQDVSIHGTLPRKKKGPPSIRSCDNAG---- --HSKSPRQSSPLTQDIIQENPL--------------------------------------------------------- ----------------------------------------------------------------------QDRKGENFIF RDPYLLDPTL---EYVKFSKERHIMD------RTPER-LKKELEEELL-LSSED----------LRSHAWYHGRIPR--- QVSENLVQRDGDFLVRDSLS----SPGNFVLTCQWKNL-AQHFKINR-TVLRL---SEAYSRVQYQFEMESFDSIPGLVR CYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTS-PG-------RGREGSLAEGRPDVVKRL-------SLTTGSS- -----------IQAREHSLPRGN-------------------------LLRNKEK--------SGSQPACLDHVQDRKA- ------------------------LTLKAHQSESHLPIGCKLPPQSP---SMDTSPCPSSPVFRTGSEPTLSPALVRRFS SDART-GEALRGSDSQLCPKPPPKPCKVPFLKT---------------PPSPSPWLTSEANYCELNPAFAVGC----DRG AKLPMQAHDSHEMLLTAKQNGPSGPR------NSGINYMILDG-DDQAR----------------HWDPLAVQTDEG--- -QEDKTKFVPPLMETVSSFRPNDFESKLLPP-ENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDRKR -SM---------GVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAVELKD-AMGDL YAFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRE-STYVPASNVSVPLLMPLVTLMERQ--- ----------------AVTFEGTDMWENNDESCEILLNHLATAR-FMAEASESYRMNAERILAD-F-QPDEEMTEILRTE FQMRLLWGSKGAEVNQNERYDKFNQILTALSRKLEPPSGKQAEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Rattus_norvegicus_BCAR3 ------------------------------------------------------------------------MAAGKFAS LPRHM--PV--NHQFPLASSMDLLSSKSPL-AEHRTE-----------AYPDVSIHGTLPRKKKGPPPIRSCDSASHMGT LPHSKSPRQSSPLTQDLILEKPL--------------------------------------------------------- ----------------------------------------------------------------------PDWKGDSFAF RDPYLLDPTL---EYVKFSKERHIMD------RTPER-LKKELEEELL-LSSED----------LRSHAWYHGRIPR--- QVSENLVQRDGDFLVRDSLS----SPGNFVLTCQWKNL-AQHFKINR-TVLRL---SEAYSRVQYQFEMESFDSIPGLVR CYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTS-PG-------RGREGSFAEGRPDVVKRL-------SLTTGG-- -----------IQARDHSLPRGN-------------------------LLRNKDK--------SGSQPACLDHVQDRKA- ------------------------ATLKAHQSESHLPIGCKLPPQSP---SVDTSPCPNSPVFRTGSEPTLSPALVRRFS SDARA-GEALRGSDSQLCPKPPPKPCKVPFLKV---------------PPSPSPWLNSEANYCELNPAFAVGC----DRG AKLLSQALDSHEMLLTAKQNGASGPR------NSGINYSILDG-DDQGR----------------HWDPLAVQTDEG--- -QEDETKFVPPVMETVSSFRPNDFESKLLPP-ENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDMKR -SM---------GVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAMELKD-TMGDL YSFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRE-STYVPASSVSVPLLMPLVTLMERQ--- ----------------AVTFEGTDMWEKNDESCEIMLSHLATAR-FMAEASESYRMNAERVLAD-F-QPDEEMTEILKTE FQMRLLWGSKGAEVNQNERYDKFNQILTALSRKLEPPSGKQAEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Oryctolagus_cuniculus_BCAR3 ---------------MLALCRKQFEEKAIDCFNNFCDFLRQTELLPPRHTWILKAAKFRFLGPVPNIKELRVMAAGKFAS LPRNM--PV--SHPSPLASSMDLLSSTSPL-AEHHAD-----------AYPDASIHGTLPRKKKGPPPIRSCDSFSHMGT LPHAKSPRQSSPRTQDVIRESPL--------------------------------------------------------- ----------------------------------------------------------------------QDWKGETFTF RDLHLLDSTL---DYVKFSKDRHVMD------RTPER-LKKELEEELL-LSSED----------LRSHAWYHGRIPR--- QVSENLMQRDGDFLVRDSLS----SPGNFVLTCQWKNL-AQHFKITR-TVLRL---SEAYSRVQYQFETESFDSIPGLVR CYVGNRRPISQQSGAIIFQPINRTVPLRCLEERYGTT-PG-------RARDSSLAHGRPDVTRRL-------SLSPGS-- -----------VQAREQSLPRGN-------------------------LLRNKEK--------SGSQPACLDHMQDRRA- ------------------------LSLKAHQSESYLPIGCKLPPQPP---GVDTSPSPNSPVFRTGSEPTLSPAVVRRVS ADPRS-GEALRGSDSQLCPKPPPKPCKAPVLKA---------------PLSPPTQLSAEANYCELNPACAAGG----DHG VRPPLCALGSHVQLPTARLSEAPGSR------NSGTSYLILDG-DDGAR----------------PWEPPAAQMEEGT-- CKEDTGEFVAPLLETVSSFRPNDFESKLLPP-ENKPLETAMLKRAKELFASHHPRVIAQHLLHTDCKVARILEVSEETRR -NM---------GVSSGLELLTLPHGRQLRLDIIERHNTMAIGVAVDILGCTGSLEDRAATLNRIIQVAAELKD-AVGDL YSFSAIMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKVLHEGRE-PTCVPPCSVSVPLLMPLVTLMERQ--- ----------------AVTFEGTDLWEKHDQSCEIMLNHLAAAR-LMAQAADSYRANAERMLAG-F-QPDEEMSEVFKTE FQMRLLWGSKGAEVNQTERYEKFSQILTALSRKLEPPPAKQAEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Canis_familiaris_BCAR3 ------------------------------------------------------------------------MAAGKFVN LPRNM--PV--NHQFPLASSMDLLSSKSPP-AEHHTD-----------AYQDVSIHGTLPRKKKGPPPIRSCDNFSHMGT LPHSKSPRQSSPLTSAIIQEHPL--------------------------------------------------------- ----------------------------------------------------------------------QDWKGETFTF RDQHLLDPTL---EYVKFSKDRHVMD------RTPER-LKKELEEELL-LSGED----------LRSHAWYHGRIPR--- QVSENLVQRDGDFLVRDSLS----SPGNFVLTCQWKNL-AQHFKIHR-TVLRL---SEAYSRVQYQFETESFDSIPGLVR CYVGNRRPISQQSGAIIFQPINRTVPLRCLEERYGAS-PG-------R---------RPDVGKRL-------SLTMGG-- -----------VQAREQSSPKGN-------------------------LLRNKEK--------SGSQPACLDHMQDRRA- ------------------------LSLKAHQSESYLPLGCKLSSRSP---SVDTSPRPNSPVFRTGSEPTLSPALVRRVS SDARA-GEALRGSDSQLCPKPPPKPCKAPLLQP---------------PPSPSTWLNSEANYCELNPAFATGG----DRG ARPPLCAHDSYVELLTAKQNGVLGPR------HSGTNYLILDD-D-GAG----------------PGEAPATQMDQG--- QQEDEGEFVLPRLETASSFRPNDFESKLLPA-ENKPLEMAMLKRVKELFTSKDPKAIAQHMLSTDCMVARILAVSEETRR -NM---------GVSSGLELLTLPYGHQLRLDIIERHNTMAIGIAVDILGCTSTLEDRAATLNRIIQVAVELKD-SMGDL YSFSAIMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKMLHEGRE-SMCVPPNKISVPLLLPLVTLMERQ--- ----------------AVTFEGTDMWEKNDESCEIMLNHLATGR-LMAETADSYRMNAERILEG-F-QPDEEMSEIFKTE FQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Felis_catus_BCAR3 -------------------------------------------------------------------------------- ---------------------------------------------------------------------MHCSQFSYL-- -PFS---------------------------------------------------------------------------- ------------------------------------------------------------------------------LF RDQHLLDPTL---EYVKFSKERHVMD------RTPER-LKKELEEELL-LSGED----------LRSHAWYHGRIPR--- QVSENLVQRDGDFLVRDSLS----SPGNFVLTCQWKNL-AQHFKIHR-TVLRL---SEAYSRVQYQFETESFDSIPGLVR CYVGNRRPISQQSGAIIFQPINRTVPLRCLEERYGAS-PG-------RAREGSLAEGRSDVGKRL-------SLTMGG-- -----------LQAREQSSTRGN-------------------------LLRNKEK--------SGSQPACLDHMQDRRA- ------------------------LSLKAHQSESYLPIGCKLPPQSP---GVDTSPCPNSPVFRTGSEPTLSPAVVRRVS SDARA-GEALRGSDSQLCPKPPPKPCKAPVLKA---------------PPSPSTWLNSEANYCELNPGFAAGC----DRG TRPPLCAQDSYVELLTAKQNGAPGPR------NSGINYLTLDD-DVGAG----------------PWEAPATQKDQG--- Q-EDEVEFVPPRLETASSFRPNDFESKLLPP-ENKPLETAMLKRAKELFTNNDPKVIAQHMLSMDCVVARILEVSEEMRK -NM---------GVSSGLELITLPYGHQLRLDIIERHNTMAIGIAVDILGCTGSLEDRAATLNRIIQVAVELKD-SMGDL YSFSAIMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKILHEGRE-STCVPPNKISVPLLMPLVTLMERQ--- ----------------EVTFEGTDMWEKNDESCEIMLNHLATAR-LMAEAADSYRMNAERILEG-F-QPDEEMSEIFKTE FQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Bos_taurus_BCAR3 ------------------------------------------------------------------------MAAGKFAS LPRNM--PV--NHQFPLASSMDLLSSKSPL-VERRAD-----------AYQDVSIHGTLPRKKKGPPPIRSCDNFSHVGT LPHSRSPRHHSPLIQDVIQEQPL--------------------------------------------------------- ----------------------------------------------------------------------QDWKGEAFTF RDQHLLDPTL---EYVKFSKERHVMD------RTPER-LKKELEEELL-LSSED----------LRSHAWYHGRIPR--- QVSENLMQRDGDFLVRDSLS----SPGDFVLTCQWKNL-PQHFKIRR-TVVRL---SEAYSRVQYQFEMESFDSIPGLVR CYVGNRRPISQQSGAIIFQPVNRTVPLRCLEERYGASSPD-------RAHEGSLTEGRPDAAKRL-------SLTVGG-- -----------TQAREQGLPRGN-------------------------LLRNKEK--------SGSQPACLDHMQDRRA- ------------------------LSLKAHQSESYLPIGGKLTPQSP---SVGTSPCPNSPVFRTGSEPTLSPAVVRRVS SDARP-GEALRGSDSQLCPKPPPKPCKAPLLKA---------------PPSPSIWLNSEANYCELNPALAASY----DGA SRLPFCAQDSYVELLTAKQNGGLGTR------NSDTSYLILDD-DDRTR----------------PWKPPPAPGDTV--- -GEDQDTFVMPLLETTSSFKPNDFESKLLPP-ENKPLETSMLKRAKELFTNSDPKVIAQHLLSVDCKVARILEVSEEMRK -NM---------GVNSGLELITLPYGHQLRLDIIERHNTMAIGIAVDILGCTGSLEDRAATLNKIIQVAVELKD-SMGDL YSFSAIMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKVLHEGRE-STCVPPNNVSVPLLMPLVTLMERE--- ----------------AVTFEGTDMWEKNDESCEIMLNHLATAR-LMAEAADSYRMNAEKILAG-F-QPDEEMSEVFKTE FQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQMEF------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Gallus_gallus_BCAR3 -----------------------------------------------------------------------MIAAGKFSS LPRNV--PVNVNHQFSLASSMDLLTTKPSL-TEHRSD-----------SFQDISIHGTLPRKKKGTVKVRACDMFSHVGM LPYTRTQRQQPPFVQDVIEEYPL--------------------------------------------------------- ----------------------------------------------------------------------QNGKSNKLHT RDQNIPDPTL---EYVKFSKERQVMD------NSPEK-LKKELEEELQ-LSSED----------LRSHAWYHGRIPR--- QVAEDLVQRDGDFLIRDSLS----CPGNFVLTCQWKNT-SQHFKINR-TILRL---SEAYCRVQYQFELESFDSIPGLVR YYVGNRTPISKQSGAIIFQPINRTVPLRCLEEKYGVI-PD-------RQKEQSIPEGKTEAAKRL-------SLGISS-- -----------MQSQEQSIPRGN-------------------------LLRNKEK--------SGSQPASLDHVLDKR-- ------------------------FPLKTHQSESYLLIGSRHSSRLP---EADADSCPSSPAFRTGSEPSLSPTVVQKVT YDSQV-GEALRGSDSQLYPKPPPKPSKATLLKT---------------TDSPMASHSSEGHYCELSLVRD-------SAA TEH-LCQKNSYVEHLTQKERGRQCFR------NSETSYLILDD-DHTVN----------------SAGPLDVSTETA--- --EENNVFSAPLFETSSSFKPNDFESKLLPS-ENKPLETSMLRKIKELFTKNNPKVIAQHILRMDCKVARILEVSEEMRR -IM---------GVNSGLELITLPYGHQLRLDLIERHNTMAIGIAVDILGCTGNLEDRAATLNKIIQVAVELKD-SLGDL YAFSAIMKALEMPQVSRLEQTWTSLRHHYTQTAIMYEKQLKPFSKALHEGQE-MVSVPQN-LTLPLLMPLVTLMERQ--- ----------------AVIFEGMDLWESSDQSCEIMFKHLTTAR-QIAQNAEMYSLTAQRMLEG-F-QPDEEMSEIFKTE FQMRLLWGSKGAQVNQNERYEKFSQILTALSRKLEPPPVKQVEQLSI--------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Taeniopygia_guttata_BCAR3 -----------------------------------------------------------------------MIAAGKFSS LPRNS--PV--NHQFSLASSMDLLTTKPSP-IEHHSN-----------SFQGISIHGTLPRKKKGTIPSRSCDMFSHVGA LPYTR-AWQQPPFVQDVIEEYPP--------------------------------------------------------- ----------------------------------------------------------------------DNGKSSELHA RDKNILDPTL---EYVKFSRERQVMD------KSPEK-LKKELEEELQ-LSSED----------LRSHAWYHGRIPR--- QVAEGLVQRDGDFLIRDSLS----SPGNFVLTCQWKNT-PQHFKIIK-TVLRL---NEAYCRVQYQFELESFDTVPGLVR YYVGNRTPISKQSGAIIFQPVNRTVPLRCLEEKYSVT-PV-------QQKEPRTPEGKMESAKRL-------SLGISS-- -----------MQYPDQSMPRGN-------------------------LLRNKEK--------SGSQPASLDHVLEKR-- ------------------------FPLKAHQSESYLLIGSRHPSRLP---EADANSCPSSPAFRTGSEPSLSPTVVQKVT SESQL-GEALRGSDGQLCPKPPPKPSKAPLMKL---------------PDSPLASHSSEGHYCELNPARHP------TAA KQC-LCQKNSYVEHLTQKER--ATFR------NSETSYLIIDD-DPTMH----------------PADPLEA--QMA--- --EEDSIFSAPVYETVSSFKPNDFESKLLPP-ENKPLETSMLRRVKELFTNNNPKIIAQHILRMDCKVARIVEVSEEMRR -NM---------GGNSGLELITLPYGHQLRLDLIERHNTMAIGIAVDILGCTGNVEDRAATLNRIIQVALELKE-SLGDL YGFSAIMKALEMPQVSRLEQTWTALRHCYTQTAIMYEKQLKPSCKALHEGQDDMCFAPQNNVTVPLLMPLVTLMERQ--- ----------------AVVFEGMELWESSDQSGEIMLRHLGTAR-LIAQHAETFRLTAEQLLQG-F-QPDEELSEIFKTE FQMRLLWGSKGAQVNQSERYEKFNRILTALSRKLEPPPVKLVEQ------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Anolis_carolinensis_BCAR3 MKHISISSWLSQLGLPEYGTLFDQQYDGVEDLLHLTEAELKRMGVKNQIHRTHIISNISLLQEAERKQELRMIAAGKFAS LPRNM--QM--SHEFSLASSMDLLTSKPSLAADHRSG-----------ICQDVSIHGTLPRKKRGPIPVGSSDPLHHMGT SPYCKGLRTQGPSIQNIIEEYPQ--------------------------------------------------------- ----------------------------------------------------------------------KNKKNDNFFS RDQNVADPTI---EYVKFSKERQVMERQVTMDSSPEK-LKKELEEELQ-MSSED----------LRSHAWYHGRIPR--- QVAESLIQRDGDFLIRDSLS----SPGNFVLTCQWKNI-SQHFKINK-TILRL---NEAYCRVQYCFEDESFDSIPGLVR CYVGNRRPISKQSGAIIFQPINRTVPLRCLEEKYGIS-PG-------MQREGSIPEGQVDTPKRL-------SLNMCN-- -----------RLAREQNSVRGN-------------------------LLRNKEK--------SGSHPACLDHVQEKR-- ------------------------FPLKAHQSESFLPIGSRHLSQGT---EAETSPCRKSPAFRTGSEPALSPLMFRRFA SELQI-NDVLRGSDSQLYPKPPPKPSKVPFLR---------------------PSHGSEVLYCELNAALPADC----RIS KQS-LCQKNNFVDYLTTKENG----T------HPEPNYLILDNRDSFLS----------------SVDPLTAQTEMS--- --NESDVFVAPVLEMVSSFQPNHFESKLLPS-ENKPLETAMLKKVKEFFTNNSAKTIAHHILKMDCKVARILEVSEEMRR -TM---------GVKSGLELITLPYGHQLRLDIIERHNTMAIGIAVDILGCTGNLEERVTTLNRIIQVAVELKE-SMGDL YAFSAVMKALEMPQVTRLEQTWTMLRHCYTQTAIMYEKQLKPFCKALHEGRE-IASVPQNIVTVPLLMPLINLLERQ--- ----------------TVVFDGMDVWENTDQSCEIMLKHLATAR-LIAQNASLYSRNAERILAG-F-QPDNEMKEIFKTE FQMRLLWGSKGAQVNQSERYEKFNQILTALSRKLESPQIKQNEL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Pelodiscus_sinensis_BCAR3 -----------------------------------------------------------------------MIAAGKLAS LPRNM--QV--NHQFSLASSMDLLSSKPPL-AEHHLD-----------SYQDISIHGTLPRKKKGAIPIRSCDMFSHMGT LPFPKTHRQQSPLIQDVLEKCSL--------------------------------------------------------- ----------------------------------------------------------------------QDRKSEKHQF RDQNILDPAM---EYVKFSKERQVMD------STPEK-LKKELEEELQ-LSSED----------LRSHAWYHGRIPR--- QVAESLVQRDGDFLIRDSLS----SPGNFVLTCQWKNI-SQHFKINR-TILRL---NEAYCRVQYQFELESFDSIPGLVR CYVGNRRPVSKQSGAIIFQPINRTVPLRCLEEKYGVS-PV-------RQRECNITEGKTEIARRL-------SLSICS-- -----------VQPQEHSLTRGN-------------------------LLRNKEK--------SGSQPASLDHVQEKR-- ------------------------FHLKTHQSESYLPAGLRHPFQLP---EVDTNPRSNSPTFRTGSEPTLSPTVGQRVA SELPV-GEALRGSDSQLCPKPPPKPNKVPFLRQ---------------PQSPLAWHSSEAHYCELNPATSIDC----EAT QQP-LSQKSSYVEHLIAKENGLLSFR------NSEESYLIHED-DALLS----------------SMDPLALRTEMA--- --EEASVFVAPVLETESSFKPNDFESKLLPP-ENKPLETPMLKKVKELFTNSNPKIIAQHMLRMDCKVARILEVSEELRR -SM---------GVSSGLEFITLPYGHQLRLDIIERHNTMAIGIAVDILGCTGNLEERAATLNRIIQVAVELKD-SLGDL YAFSAVMKALEMPQIARLEQTWTTLRHHYTQTAIMYEKQLKPFSKALQEGGE-TICVPQNNITVPLLMPWVTLMERQ--- ----------------FVIFDGLDLWEYTDQSCEIMLKHLATAR-FIAQNADMYRMTAERKLEG-F-QPDDEMSEIFKTE FQMRLLWGSKGAQVNQRDKSLIFKLIMSLQFKFSPNLLCSPLVK------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Xenopus_tropicalis_BCAR3 ------------------------------------------------------------------------MAAGKFAS YHRNV--QM--NHQFPLVSSMDLLGSKSAL-GERRSD-----------SFQNVCIHGTLPRKKKERVPIKSSDVFCHLGT LPHSKSHRLPNPVMQDIKEEYPF--------------------------------------------------------- ----------------------------------------------------------------------QERRTGIFNM REYY-LDPSM---EYVKFSKDRYIMDG-----GTPDK-LKKELEEELK-LNSED----------LRSHAWYHGRIPR--- QVSENLVKRDGDFLIRDSLS----SPGNFVLTCQWKNL-SQHFKINK-VVIRL---NEAYCRIQYQLEHESFDSMPALVR YYVGNRKAVSQQSGAIIFQPINRTVPLRCIEEKYGTS-PV-------RRLELGPLEAKAEVPKRL-------SLNFGQ-- -----------GVSQEQSLARGN-------------------------LLRNKDK--------SGSQPACLDNMREKR-- ------------------------RPLKAHQSESYLPLGSRHPCLSQ---GMDVKVSPKAHVFRTGSEPALSPTEIRRFS NEAHP-AEALRGSDSQLCPRPPPKPSKAPSIKQ---------------SHSPLVWQSSEANYCELHPTPPEDC----AWS DSY--SSRNSYIEDQRTDDIESLSFS------NSELSFPALDD----------------------SISQCSATNFCG--- -NVEDNEFNRPVYETVSSFCPNDFQSVLLTA-ENKPLETALLRRAKELFTNNDPKTIAKHILRMDCKVARILDVTPEVEK -MM---------GVSSGLELIILPFGHQLRLDLMERHTTMAIGIAVDILGCTGNLEERVATLHKIIQLAVEVK--ALGDY FAFSAIMKALDMPQITRLEQTWTMLRHQYTHTAITYEKQLKPFSKYLHEGEA---LDTQEDLTVPLVMPLVALLERQ--- ----------------SVIFEGMDFWENHDRGCEIMFNHLQTAR-QVAQYASVYRKNAERILEG-F-KPDELMSEIFKTE FQMRLLWGSKGALLKQSERYHKFGQILTALSRKLEPPS------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Danio_rerio_BCAR3_a MKHMSISKWLSQLGLPQYCILFDEEYDGVEDLLHLTEMDLLGLGVQSRLHRIHILSSIQVLRERETKRELRMMAEGRFSS LPRNMHV----GRQCPLASSMDLLSSRPEL-SEMPVS-----------GYQGISIHGTLPRKKKTTTGSPVKQWEVNGNV GSLAAPYPGRHRLPPSPLIHNII--------------------------------------------------------- ----------------------------------------------------------------------EEHQTFCSDR KQSRNSAGMDPTMEYVKFSRDKYILD------GPPEK-LRRELEEELK-LSSEE----------PRSHAWYHGAIPR--- QVAENLVQRDGDFLIRDSLS----SPGNYVLTCQWKNS-PQHFKINK-RVVAM---NEAYSRVQYLFEKEGFDSIPALVR YYVGNREPVSEVIGAIIFQPINRALPLRCLEEKYGVG--S-------IRVEAGYLERKSLTSKRL-------SLNIMN-- -----------GHGQDHTLSRGN-------------------------LLSNKDK--------CGSQPACLNHVQERR-- ------------------------RPLKTHQSESFLPIGS--RPQAQV-QHMEHQPCPKSPVFRTGSEPALSPTVPRRMA FDTLP-GEAIRGSDSQLCPKPPPKPSKVPTVRVPCIPALKTLVVPPVPPVKPHKHRPSLQQQQSGSPEMSYCE----LSP CSPADWEKMNSLQANGYVERLKTDGS------IKLDRSSYHNAIEALDN---------------DSEEDTEEDADKEQ-- --NGKKAFQKPVFETESAFRPANVNFRLLPK-ENKPLEMTVLKKAKELLVSQDPKTIAKHILQADCQVARILNVSEEVKG -QM---------GVSSGLELVTLPHGRQLRLDLIERHNTMAIGVAVDILGCTGSLEERAATLNRIILVALELKD-SMGDL YAFSSIMKALDMPQITRLDHTWTSLRRKYTQTAIIYEKSLKPFYKGLYEGGAEIPLS---NASVPLLMPLLTLMERP--- ----------------AVTFEGMDVWENTDQGCEIMFRHLEGAR-AVARNADTYTCNAQRILQD-F-QPHEDMLEILRTD FQLRLLWGSRGAAVEQTERYDKFKLILTALSRKLEPAVKHTEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Takifugu_rubripes_BCAR3_a ------------------------------------------------------------------------MSER---- --------------CTLKTLTATLC------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------CFYQ KSSVITA---------KFSRDQFILE------CPSEK-LRKELEEELK-MDCEE----------LRSHAWYHGAIPR--- QVAETLVQRDGDFLIRDSLS----SPGSYVLTSQWRNT-AQHFKINK-KVVTL---NEAYTRVEFRLDREGFDNVPALIR YYVGNRKPVSPVVGAIIFQPINRVLPLRCLEEKYGVS--N-------NHRER-LMVQERRSQKRL-------SLNITN-- -----------GHAHDGNLSSP----------------------------RTKDR--------CGSQPASLNQVHDRR-- ------------------------RPLKAHQSESYLPLGKRAPPHPLA-DSVPLSPSHKSPVFRTGSEPVLSPSVPRRSA ELLS--GQPIRGSDSQLCPKPPPKPSKVLLSRL------------CPPADPPSLNAPQLDSSCAETPALPRRT----GVD LQVPLCGHVERLRREEVGEGEAVGRR------G-LDRSSYHHASAPLEY---------------TSEEEEEDRKRK---- ----TLGFLRPIVETESTFRPADFGSRLLPP-ENKPLEMLVLKRAKELLLSHDHQSIARHLLKADCQVARIIGVTPELKS -QM---------GVASGLELVTLPHGRQLRLDLMERHHTMAIGVAVDILGCTGSVDERATTLNRIILVALELKD-AVGDL FAFTALMKALDLPQISRLEETWTTLRRNYTQTAISYEKTLKPFFKNLYEGTASCPP----TVCVPVLLPLLTLMERS--- ----------------SVMSEGAELWETNDQGCDIMLRHLEAAR-GVAHNTWSYAQNAEKMLQE-F-RCDDELLEVFKTD FQLRLLWGSRGACVNQSDRYNKFNLILTALSRKLEPPPKTQTVI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Gasterosteus_aculeatus_BCAR3_a ------------------------------------------------------------------------MSEG---- --------------CSLKTLTAALC------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------CFYH KNSVMTA---------KFSRDQFIVD------CPSEK-LRKELEEELK-MNCEE----------PRSHAWYHGAIPR--- QVAEYLVQRDGDFLIRDSLS----SPGCYVLTCQWRNA-AQHFKINK-KVVML---NEAYSRVEYRLEREGFDNVPALIR YYVGNRKSVSQVVGAIIFQPINRGLPLRCLEEKYGLS--S-------HRRDA-LMAQERRSRKRL-------SLNVTN-- -----------GHAQDDARGAQNGARGRG--------------------LRFKDR--------CGSQPASLNQVPERR-- ------------------------RPLQAHQSESYLPLGS--KPQRSP-DPLLPSPSPKSPVFRTGSEPVLSPSVPRRPA ELLA--GQAIRGSDSQLCPKPPPKPSKVPLAR--------------PPAPPPGAPGLTHATSGSNAPALASAC----VQT LASPRS--SEGINSEIVYSASAGPPV------PPVKPLKFLHQLRPEDTR---G--------FSTSALSPTENGWK---- ----RSRFQRPVEETESAFQPAQFGSRLLPP-ENKPLETVVLKRAKELLLSHDHHSIARHLLLADCQVARTVGVTPEVKG -QM---------GVSSGLELVTLPHGRQLRLDLMERHHTMAIGVAVDILGCTGSVDERASTLNRIILVALELKD-AVGDL FAFTALMKALDLPQISRLEETWTTLRRTYTQTAISYEKTLKPFYKNLYEGTASSPA----VVCVPLLLPLLTLMERP--- ----------------SITPEGAELWETSDQGCDIMLRHLEDAR-DVAHNAQRYTINSQMILEG-F-PCDEDLLEVFKTD FQLRLLWGSRGASVNQSDRYNKFNLILTALSRKLEPPPNTQIVI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Oryzias_latipes_BCAR3_a ------------------------------------------------------------------------MSER---- --------------CNLKALTAALC------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------CFNH KNSVISG---------KFSRDQFILD------CSSEK-LRRELEQELK-MNCEE----------PRSHAWYHGAIPR--- QVAENLVQRDGDFLVRDSLS----SPGSYVLTCQWRNA-PQHFKVNK-KVVML---NEAYSKVEYRLDKDGFDSVPSLIR FYVGNRKPVSQVVGAIIFQPINRSLPLRYMEEKYALS--G-------NQREAGLVAQEKPCQKRL-------SLNITNGI -----------GHPVQDGSHCPDNSLSRSS------------------HLRLKDR--------CGSQPASLNQVQERR-- ------------------------RPLKAHQSDSFLPLGSKPQSQQSP-DPLLPSP--KSPVFRTGSEPALSPCVPRRSA EHQAAAGQAIRGSDSQLCPKPPPKPSKLLLAQS------------PQAPSVQPSRSPASSPSWAVSPLAASSC----SAA TACPKTSQRTYMQLSDCRPSRSPGKA------P----NSYHHTIEASEH---------------TSEEEEEEDGERDLPK RGKVRGGFRRPVEETESMFRPTDFESRLLPP-ENKPLEMVVLRKAKELVLSHDHQSLARHLLMADCQVARILGVTPEMKG -QM---------GVSSGLELVTLPHGRQLRLDLMERHHTMAIGVAVDILGCTGSVEERASTLNRIILVAQELKD-EVGDL YAFTALMKALDFQQISRLEETWTTLRRNFTQAAISYEKILKPFYKSLYEGTVSSAAPSSKALCLPMLLPLLTLMERP--- ----------------LIPPEGAEFWETSDEGCDIMLRHLEAAR-IVAQNAQSHTSNAQMILKG-F-EFDEGLLEVFKTD FQLRLLWGSRGATVNQSDRYNKFNLILTALSRKLEPPATTQPLI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Nematostella_vectensis_BCAR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------MSK KSNKLSRTFPGRVKNETKSRQPLPSG-----FKRFADFLTLRRKKRKGDSAARQ----------LEKSPWFHGKITA--- EYAEMLMRGAGEFLVREDPA----MPGMYFIAVRNKEQETLHLAITK--VNHS---KGTRIKYRVEDSDYMFDGIPELIQ FYISERRPVSIRPPAVLTIAISKESALLKEEDFRGRTSTAG------SARIHRTTRGRLERKRSD--------------- ------------PVLSTRVPSRVFN-----------------------IEADDDS----------SASVPDKDRPHSRSN ------------------------PPSIYYDDKQKTAEGGELFSSATTQSLEDVLDPPQIERRRHLSSSGSAPSLYRKRD SGEGP--ESTYDSPRSIAIPTTTLKHVSPYGRQG------------------RKRSQESGPVQALKSKEGVPLK------ ---------DYATPSSLPVNGSSNSQDELDYDVPRPSSMVTDK----------------------NNDDTNSKRDSG--- ----VTRESSTERDRAGSGVTECAKPRQTRQEIYQSVLQKLRDKIVRPFLEQSCVTLARYMTKVDLDVVWTSHMGEGEGE -PE---------GVAEGLELLILPQGRDIRSALIERYTNLTYWVG-ALVVAAGDLGPRTQVVTKLIELADVLSD-KHGNL VSFMAVLEGLALPQVTRLHHTWSCLHHQYSSSAIMYHSTLKPLAGLLSSGAP----SPFPGVCLPYVVPLAKLLEMT--- ----------------TEDALGGWGQDDVVQGIETLLAHLDAGR-TLIQQLDAYKDEYLKRSHETIPEDELKIMDYFRSR VNVGDVLGLGSDAHVRTQKLVTLLNWLSENAERASKPSADIWQATNAMAISIVCKPFDFFAIMKSGRLKGQIGRMNRGAN LSAKIRLFSLHLKFPTDEKFTISRVCPGMTVKDLKNRIELETGVPRHLLRLRYLDGYDLTDDRRLSYYNMVPAATVQVLL WPEWVSLVTAACKGDYYGNQIGVFNFFRGVLASQIRTPAKLGQNTPREFNEKALVALYIASHRGHVNVVSRLVESGVYPC TKLPSGRSPLHAAVNRKQITCVSILIGELYIDRVILSSAGRD >Hydra_magnipapillata_BCAR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MSVILG-------------SLMYNLDSEIQN- ------------------------TVGRMP-------------------------------------------------- --------IESLNLSPWFHGKIDRATISRLLKH-------------------------DGDFIVREKSDNSG-------- ------------TNVLSVLWKGS------------------------------------------IKHFILKANDKG--- ------LYTLEGESFSSINALITHHYERRSV-IQSSTGIILMNSVNR---------------------------IFMDG- ------------DDYIVPQ-----------DDVQLKCKLGGGHFGD--------------VYKVLELCDKGDLLALLKKE GPNFTQMKLFDMSMDIARGMAYLEQKQIIHRDLAARNCLVTNDYDVKISDFGMSREEDDEGTYTIQTTKEIPFKWCAP-- ----------------EVWLDTKYSTKTDVWSYGVTLYEIYSLG-QQPYPGWTNKQAREEINAG-YRMPSPAKTPPEVY- ELMRKCWHFSDFERPSFSEIINIFENIRLHIFKMNFLK------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Homo_sapiens_SH2D3C ----------------------------------------------------------------------MTEGTKKTS- KKFKFFKFKGFGSLSNLPRSFTLRRSSASISRQSHLE----------PDTFEATQDDMVTVPKSPPAYARSSDMYSHMGT MPRPSIKKAQNSQAARQAQEAG---------------------------------------------------------- -----------PKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTPAMEPNPS--AVEVDPIRKPEVPTGDVEEERPPRDV HSERAAGEPEAGSDYVKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSETLVQRNGDFLIRDSLT----SLGDYVLTCRWRNQ-ALHFKINK-VVVKA---GESYTHIQYLFEQESFDHVPALVR YHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGS-------SKPASPVSPSGPKGSHMK-----RRSVTMTD-- ------------GLTADKVTRS--------------DGCPTS----TSLPRPRDSIR--------SCALSMDQIPDLHS- ------------------------PMSPISESPSSPAYST-VTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTH -GESD--KGPHTSPSHTLGKASPSPSLSSYSDP------------------------DSGHYCQLQPPVRGSR------- ------------EWAATETSSQQA--------RSYGERLKE------------------------LSENGAPEGDWG--- -----KTFTVPIVEVTSSFNPATFQSLLIPR-DNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT -LM---------GVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRG-TMGNM FSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKE---GPPLSNTTFPHVLPLITLLECD--- ----------------SAPPEGPEPWGSTEHGVEVVLAHLEAAR-TVAHHGGLYHTNAEVKLQG-F-QARPELLEVFSTE FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Pan_troglodytes_SH2D3C ----------------------------------------------------------------------MTEGTKKTS- KKFKFFKFKGFGSLSNLPRSFTLRRSSASISRQSHLE----------PDTFEATQDDMVTVPKSPPAYARSSDMYSHMGT MPRPSIKKAQNSQAARQAQEAG---------------------------------------------------------- -----------PKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTPAMEPNPS--AVEVDPIRKPEVPTGDVEEERPPRDV HSERAAGEPEAGGDYVKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSETLVQRNGDFLIRDSLT----SLGDYVLTCRWRNQ-ALHFKINK-VVVKA---GESYTHIQYLFEQESFDHVPALVR YHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGS-------SKPASPVSPSGPKGSHMK-----RRSVTMTD-- ------------GLTADKVTRS--------------DGCPTS----TSLPRPRDSIR--------SCALSMDQIPDLHS- ------------------------PMSPISESPSSPAYST-VTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTH -GESD--KGPHTSPSHTLGKASPSPSLSSYSDP------------------------DSGHYCQLQPPVRGSR------- ------------EWAATETSSQQA--------RSYGEKLKE------------------------LSENGAPEGDWG--- -----KTFTVPIVEVTSSFNPATFQSLLIPR-DNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT -LM---------GVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRG-TMGNM FSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKE---GPPLSNTTFPHVLPLITLLECD--- ----------------SAPPEGPEPWGSTEHGVEVVLAHLEAAR-TVAHHGGLYHTNAEVKLQG-F-QARPELLEVFSTE FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Macaca_mulatta_SH2D3C ----------------------------------------------------------------------MTEGTKKTS- KKFKFFKFKGFGSLSNLPRSFTLRRSLAPISRQSHLE----------PDIFEATQDDMVTVPKSPPAYARSSDMYSHMGT MPRPSIKKAQNSQAVRQAQEVG---------------------------------------------------------- -----------PKPNLVPRGVPDPPGLEAAKEVMVKANGPLEDIPAVEPNPS--AVEVDPIRKPEVPTGDTEEERPPRDV HSERQAG-EVAGWLFLKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSETLVQRNGDFLIRDSLT----SLGDYVLTCRWRNQ-ALHFKINK-VVVKA---GESYTHIQYLFEQESFDHVPALVR YHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGS-------SKPASPVSPSGSKGSHMK-----RRSVTMTD-- ------------GLTADKVTRS--------------DGCPTS----TSLPRPRDSIR--------SCALSMDQIPDLHS- ------------------------PMSPISESPSSPAYST-VTRVHAAPAAPSATALPASPVTRRSSEPQLCPGSAPKTH -GESD--KGPHTSPSHTLCKTSPSPSLSSYSDP------------------------DSGHYCQLQPPVRGSR------- ------------EWAAAEASSRQA--------RSYGEKLKE------------------------LSENGAPEEDWG--- -----KTFTVPIVEVTSSFNPATFQSLLIPR-DNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT -LM---------GVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRG-TMGNM FSFAAVMGALDMAQISRLEQTWVALRQRHTEGAILYEKKLKPFLKSLNEGKE---GPPLSNTTFPHVLPLITLLECD--- ----------------SAPPEGPEPWGSTEHGVEVVLAHLEAAR-TVAHHGGLYNTNAEVKLQG-F-QARPELLEVFSTE FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Callithrix_jacchus_SH2D3C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M HSERAAGELEAGGDYVKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSETLVQRNGDFLIRDSLT----SLGDYVLTCRWRNQ-ALHFKINK-VVVKA---GESYTHIQYLFEQESFDHVPALVR YHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGS-------SKAASPASPSGPKGSHMK-----RRSITMTD-- ------------GLTADKVTRS--------------DGCPTS----MSLPRPRDSIR--------SCALSMDQIPDLHS- ------------------------PMSPISESPSSPAYST-VTRVHAAPAAPSATALPASPVARRSSEPQLCSGSAPKIH -GESD--KGPHASPSHTLCKASPSPSLSSYSDP------------------------DSGHYCQLQPPVRGSR------- ------------EWAAAEASSRQA--------RSYGEKLKE------------------------LSENGAPEGDWG--- -----KTFTVPIVEVTSSFNPATFQSLLIPR-DNRPLEVGLLRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQT -LM---------GVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRG-TMGNM FSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKE---GPPLSNTTFPHVLPLITLLECD--- ----------------SAPPEGPEPWGSTEHGVEVVLAHLEAAR-TVAHHGGLYHTNAEVKLQV-L-HCRPELLEVS-AR SQMRLLWGSQGSSSSQARRYEKFDKVLTALSHKLEPAIRSSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Mus_musculus_SH2D3C ----------------------------------------------------------------------MTEMPKKTG- RKFKFFKFKGLGSLSNLPRSFSLRRSSASASIRSCPE----------PDTFEATQDDMVTLPKSPPAYARSSDMYSHMGT MPRPNIKKAQKQQAVQKAQEVS---------------------------------------------------------- -----------RESHLVSRRLPEPPDLEAAKEAGEGTEALLEDT-----APS--AVEVDPMRELEDLTVDTEKEQVPGDV SPERTAAELEAAGDYVKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSETLVQRNGDFLIRDSLT----SLGDYVLTCRWHNQ-ALHFKINK-VVVKA---GESYTHIRYLFEQESFDHVPALVR YHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLSQGS-------SKTASPASPSGSKGSHMK-----RRSITMTD-- ------------GLTTDKVTRS--------------DGCPNS----TSLPHPRDSIR--------NCALSMDQIPDLHS- ------------------------PLSPISESPSSPAYST-VTRVHAPSATPSTSAQPASPVARRSSEPQLCPGNTPKPP -GESD--RAPHASPSHTLCKASPSPSLSSYSDP------------------------DSGHYCQLQPPVRGSR------- ------------EQAAGETP-RKA--------RGSGERQKE------------------------LLENGVSDGEWG--- -----KTFTVPVVEATSSFNLATFQSQLIPK-ENRPLEVALLRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQT -LM---------GVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRG-TMGNM FSFAAVMGALEMAQISRLEQTWMTLRQRHTEGAILYEKKLKPFLKSLNEGKE---GPPLSNTTFPHVLPFITLLECD--- ----------------SAPAEGPEPWGSTEHGVEVVLAHLEAAR-TVAHHGGLYHTNAEVKLQG-F-QARPELLEVFSTE FQMRLLWGSQGANSSQAWRYEKFDKVLTALSHKLEPAIRSSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Rattus_norvegicus_SH2D3C ----------------------------------------------------------------------MTEMPKKTG- KKFXXXKFKGLGSLSNLPRSFSLRRSSASPSIRSCPE----------PDTFEATQDDLVTLPKSPPAYARSSDMYSHMGT MPRPNIKKAQKQKAVQKAQEVS---------------------------------------------------------- -----------RESHLVSRGLPEPPDFEAAKEAEKGTETPLEDT-----TPS--AVEVDPMRKLAGLTVDTAEKQIPGDA YPERAAAELEAAGDYVKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSETLVQRNGDFLIRDSLT----SLGDYVLTCRWHNQ-TLHFKINK-VVVEA---GESYTHIRYLFEQESFDHVPALVR YHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLSQGS-------SKAASPASPSGPKGSHMK-----RRSVTMTD-- ------------GLTSDKVTRG--------------DGCPNS----TSLPHPRDSIR--------NCALSMDQIPDLHS- ------------------------PLSPISESPSSPAYST-VTRVHAASAAPCT-AQPASPVARRSSEPQLCPGGAPKPP -GESD--RGPHASPSHTLCKASPSPSLSSYSDP------------------------DSGHYCQLQPPVRCSR------- ------------EPTAGETP-RKA--------RSSAERQKE------------------------LSENGVPEGEWG--- -----KTFTAPVAEATSSFNLATFQSQLIPK-ENRPLEVGLLRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQT -LM---------GVRWGMELLTLPHGRQLRQDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRG-TMGNM FSFAAVMGALEMAQISRLEQTWMTLRQRHTEGAILYEKKLKPFLKSLNEGKE---GPPLSNTTFPHVLPFITLLECD--- ----------------SAPAEGPEPWGSTEHGVEVVLAHLEAAR-TVAHHGGLYHTNAEVKLQG-F-QARPELLEVFSTE FQMRLLWGSQGANSSQAWRYEKFDKVLTALSHKLEPAIRSSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Canis_familiaris_SH2D3C ----------------------------------------------------------------------MTEGPKKAS- RKFKFFKFKGLGSLSNLPRSFTLKRSSTSSSIESHLE----------PDTFEATQDDMVTVPKSPPAYARSSDMYSHMGT MPRLSIKKARDPQATHKTKEVG---------------------------------------------------------- -----------LEPHLVAQGLPNPPGLEAAKEVVVETKPPLEDTPAVGPNP----SAMSPTEKPKDPRADRKEERDPRNV PPERVAGEPEAGGDYVKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSETLVQRNGDFLIRDSLT----SLGDYVLTCRWRNQ-ALHFKINK-VVVKA---GESYTHIQYLFEQESFDHVPALVR YHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEACYGLGQGS-------SKAASPASPSGPKGGHMK-----RRSVTMTD-- ------------GLTADKVTRSS-------------DGCPAS----TSLPHPRESIR--------NCALSMDQIPDLHS- ------------------------PMSPISESPSSPAYST-VTRVHATSAAPSATALPASPVTRRSSEPQLCPGSTPKPP -GESD--KGPYASPSHTLCKASPSPSLSSYSDP------------------------DSGHYCQLQPPVRGSR------- ------------EWAMAEASGRQA--------RSYGERLKE------------------------LSENGASEGDWG--- -----RAFTAPVVEATSSFNPATFQSLLIPK-DNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT -LM---------GVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRG-TMGNM FSFAAVMGALDMAQIARLEQTWVTLRQRYTEGAILYEKKLKPFLKSLNEGKE---GPPLSNTTFPHVLPLITLLECD--- ----------------SAPAEGPEPWGSTEHGVEVVLAHLEAAR-TVAHHGGLYHTNAEVKLQG-F-QARPELLEVFSTE FQMRLLWGSQGASSNQARRYEKFDKVLTALSHKLEPAVRSSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Felis_catus_SH2D3C ----------------------------------------------------------------------MTEGPKKAS- RKFKFFKFKGLGSLSNLPRSFTLKRSSASISIRSHLE----------RDTFEATQDDMMTVPQSPPAYARSSDMYSHMGT MPRHSTKKARDQQATRETKEVG---------------------------------------------------------- -----------SESHLLPQDLPNPPGLEASKEVVVGTNAPLEDTPAVGPNP----SVMGPVGEPEDPSADRKEETAPRNV PPERAAGEPEAGGDYVKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSETLVQRNGDFLIRDSLT----SLGDYVLTCRWRNQ-ALHFKINK-VVVKA---GESYTHIQYLFEQESFDHVPALVR YHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEACYGLGQGS-------GKAAGPASPSGPKGSHMK-----RRSVTMTD-- ------------GLTADKVTRS--------------DGCPTS----TSLPHPRESIR--------NCALSMDQIPDLHS- ------------------------PMSPISESPSSPAYST-VTRVHAAPAAPSATALPASPVTRRSSEPQLCPGSAPKPP -GESD--KGPYASPSHTLCKASPSPSLSSYSDP------------------------DSGHYCQLQPPVRGSR------- ------------EWAAAEASSRQA--------RSYGERLKE------------------------LSENGAPEGDWG--- -----RAFTVPIVEATSSFNPATFQSLLIPK-DNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT -LM---------GVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRG-TMGNM FSFAAVMGALDMAQIARLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKE---GPPLSNTTFPHVLPLITLLECD--- ----------------SAPAEGPEPWGSTEHGVEVILAHLEAAR-TVAHHGGLYHTNAEVKLQG-F-QARPELLEVFSTE FQMRLLWGSQGASSNQARRYEKFDKVLTALSHKLEPAVRSSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Bos_taurus_SH2D3C ----------------------------------------------------------------------MTEGTKKAS- KKFKFFKFKGFGSLSNLPRSFTLRRSLAPNSIRPQVE----------ADTFDATQDDMVTVPKSPPAYARSSDMYSHMGT MPRPSIKKAQGKQATQKAQEVG---------------------------------------------------------- -----------PEPQVVPRSLPDPPGLEAAEKVVPGTIASREDTPTVGPNPS--AVEVDPTRKPEDARPDTEEGRDPKNV PSERATAEPEAGGDYVKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSETLVQRNGDFLIRDSLT----SLGDYVLTCRWRNQ-ALHFKINK-VVVKA---GESYTHIQYLFEQESFDHVPALVR YHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEACYGLGQGG-------GKAASPASPSGPKGSHMK-----RRSVTMTD-- ------------GLTADKVTRS--------------DGCPTS----TSLPHPRESIR--------NCALSMDQIQDLHS- ------------------------PMSPISESPSSPAYST-VTRVHAAPAAPSATALPASPVTRRSSEPQLCPGSVPKPH -GESD--KGPYSSPSHTLCKASPSPSLSSYSDP------------------------DSGHYCQLQPPVRGSR------- ------------EWAAAEASGRQA--------RSYGEKLKE------------------------LSENGASEGDWG--- -----RTFTVPVVEATSSFNPATFQSLLIPK-DNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT -LM---------GVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAMDILGCTGSAEERAALLHKTIQLAAELRG-TMGNM FSFAAVMGALDMAQIARLEQTWVTLRQRHTEGAILYEKTLKPFLKSLNEGKE---GPPLSNTTFPHILPLITLLECD--- ----------------SAPAEGPEPWGSTEHGVEVVLAHLEAAR-TVAHHGGLYHTNAEVKLQG-F-QARPELLEVFSTE FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAIRSSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Gallus_gallus_SH2D3C ----------------------------------------------------------------------MAEGQKRGGF KKFKFFKFKGFESLSSIPRSFTLRRVSVVPSSPESLGMCLPPPQGFLEEAFDSTQDDLNTMPKGPGPYARSSDMYSHMGT MPRLSFGKVGKSLGKARGTQS-------------------------------------------CREKGSSRDKIP---- -----------STAPRSPGAEKARMDQEIPGNSPSPGMEAPSPSLAPSPS-------AASGAETTDGDFQEKGQERPSES SPDSHHDGLESSSEYVKFSKEKYILD------SSPEK-LHKELEEELK-LSSTD----------LRSHAWYHGRIPR--- EVSESLVQRNGDFLIRDSLT----SVGDYVLTCRWRNE-PLHFKINK-VTVKS---SDGRTRVQYLFEQESFDNVPALVR FYVGNRKAISEQSGAIVYCPINRTFPLRYLEASYGLANG--------KHGGSHSPAS-QKGGHIK-----RRSITMTD-- ------------GLTADKITRA--------------EGCSTS----VSLPHHRDIIR--------NCAVSVDQIQDLHS- ------------------------PMSPISENPTSPAYST-VTRLKPHACQAAG-IAPASPVIRRSSEPQLCPGSSNKPL PDPAH---STHSTPCHGYARASPSPSVNSYSDP------------------------DTGHYCQLHPTSPSSR------- ------------ERPAHDTKQLPA--------KSYVERLKVEEGQRGTVE---N--------GSGEAEGGQRLKGERD-- ----FVGFVPPTVETCSSFNPAAFQSLLIPL-ENKPLEMAVLKKVKELVADADAKTLAKHITKVDCVVARILGVSAEMQR -LM---------GVSSGMELLTLPHGHQLRLDLLERFHTMSIMIAVDILGCTGSTEERAALLHKTIQLAAELKS-TMGNM FSFAAVMNALEMAQIARLEQTWMVLRQRHTEGAILYEKKLKPFLKSLNEGKE---GPPLTNTTFPHVMPLVTLLERD--- ----------------DALVDSPEPWEATDNGVEVVMAHLEAAR-MVAHHGGLYHTNAEVKLQG-F-QGRAELLEIFSTE FQLRLLWGSRGAESSQAERYEKFDKVLTALSHKLEPAVRFSEL------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------ >Taeniopygia_gu