>Homo_sapiens_ARID1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------S G-AAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGG- PQDGGAGKGPADMASQCWG---AAAAAAAAAAASGGAQQRSHHAPMSPGSS---------GGGGQPLARTP--QPSSPMD QMGKMRPQPYGGT---------NPYSQQ--QGPPSGP--QQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQ-- -------------IPPYGQQGPSGYGQQGQTPYYNQ--QSPHPQQQQ-----PPYSQQPPSQTPHA--QPSYQQQP--QS QPPQLQSSQ--PPYSQQPSQPPHQQSPAPYPSQ-QSTTQQH-----------PQSQPPYSQPQAQSPYQQQQP------- ----------------QQPAPSTLSQQ------------AAYPQPQSQ----------------QSQQTAYSQQRFPPPQ E--LSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLP--------------DLSGSIDDLPMGTEGALSPGVSTSG --------------ISSSQGEQ---SNPAQ-SPFSPHTSPHLPGIR----------GPSPSPVGSPASVAQSR-----SG PLSPAAVPGNQMPPRPPSGQSDSI------------------------------------MHPSMNQSSIAQDR---GYM QRNPQMPQYSSP----QPGSALSPRQPSGGQIHTGMGSYQ-QNSMGSYGPQGGQYGPQGG-----------------YPR QPNYNALP-NANYPS--AGMAGGINPMGAGGQMHGQPGIPPYGTLPPGR-MSHASMGNRPYGPN------------MANM PPQVGSGMCPP-PGGMNRKTQETAVAMHVAANS--IQNRPPG-------------------------------------- -----------------YPNMN-QGG-MMGTGPPYGQGINSMAGMINPQG-PPYSMGGTMANNS---------------- -AGMAASPEMMGLGDVKLTPATKMNNKADG--TPKTESKS---------------------------------------- -------------KKSSSST------------------------------------------------------------ -----TTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAAD--SKKSQPKIQPPSPAGS------------ -----------------GSMQGPQTPQST-SSSMAEG-GDLKPPTPASTPHSQIPPLPGMS------------------- --------------------RSNSVGIQDAFNDGSDSTFQKRNSM----------TPNP-GYQPSMNTSDMMGRMS-YEP NKDPYGSMRKA--PGSDPFMSSGQGPNGGMGD----------PYSRAAGPGLGNVAMGPRQHYPYG-------------- ------GPYDRV-RTEPGIGPEGNMS-TGAPQPN-LMPSNPDSGMYSPSRYPPQQQQQQQQR----------HDSYGNQF STQGTPSGSP-FPSQQTTMYQ-QQQQ-NYKRPMDGTYGPPAKRHEG----EMYSVPYSTGQ-GQPQQQQLPPAQPQPAS- --------QQQAAQPSPQ-QDVYNQYGNAYPATATAATERRPA--GGPQNQFPFQFGRDRVSAPPGTNAQQNMPPQMMGG PIQAS-AEVAQQGTMWQGRNDMTY-NYANRQSTGSAP-QGPAYHGVN-RTDEMLHTDQRANHEGSWPSH-GTRQPP--YG PSAPVPPMTRPPP-SNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKS-PFLHS--GMKMQKAGPPVPASHIAPAPVQP PM------------------------------------------IRRDITFPPGSVEATQPVL-KQRRRLTMKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLS-QL--PGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLL DPG---RFSKVSSPAPMEGGEEEEELLGPK-------------------------------------------------- ---------LEEEEEEEVVE------------------------------------NDEEIAFSGKDKPASENS-----E EKLISKFDKLPVKIVQKN--DPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKTELLPSRPHAPCPPAPRK HVTTAEGTPGTTDQE----------------------------------------------------------------- -----------------------------------------GPPPDGPPEKRITATMDDMLSTRSSTLTE----DGA--- ---------------KSSEAIKESSKFPFGISPAQSHRN----------------------------------------- ------------------------------------------------------------IKILEDEPHSKDETPLCTLL DWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILL--------HHKHPERKQAPLTYEKE--------- -------EEQDQGVSCNKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPE-SICLPVLDGLLHWAVCPSAEAQDPFSTL GPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIA VQKGSIGNLLGFLEDSLAATQFQQSQASLLH-----------------------------------------MQN-PPFE PTSVDMMR------------------------------------------------------------------------ ------------------------------RAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Pongo_abelii_ARID1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PPPSSSASASSSSS-FAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGG- PQDGGAGKGPADMASQCWG--AAAAAAAAAAAASGGAQQRSHHAPMSPGSS---------GGGGQPLARTP--QPSSPMD QMGKMRPQPYGGT---------NPYSQQ--QGPPSGP--QQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQ-- -------------IPPYGQQGPSGYGQQGQTPYYNQ--QSPHPQQQQ-----PPYSQQPPSQTPHA--QPSYQQQP--QS QPPQLQSSQ--PPYSQQPSQPPHQQSPAPYPSQ-QSTTQQH-----------PQSQPPYSQPQAQSPYQQQQP------- ----------------QQPAPSTLSQQ------------AAYPQPQSQ----------------QSQQTAYSQQRFPPPQ E--LSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLP--------------DLSGSIDDLPMGTEGALSPGVSTSG --------------ISSSQGEQ---SNPAQ-SPFSPHTSPHLPGIR----------GPSPSPVGSPASVAQSR-----SG PLSPAAVPGNQMPPRPPSGQSDSI------------------------------------MHPSMNQSSIAQDR---GYM QRNPQMPQYSSP----QPGSALSPRQPSGGQIHTGMGSYQ-QNSMGSYGPQGGQYGPQGG-----------------YPR QPNYNALP-NANYPS--AGMAGGINPMGAGGQMHGQPGIPPYGTLPPGR-MSHTSMGNRPYGPN------------MANM PPQVGSGMCPP-PGGMNRKTQETAVAMHVAANS--IQNRPPG-------------------------------------- -----------------YPNMY-QGG-MMGTGPPYGQGINSMAGMINPQG-PPYSMGGTMANNS---------------- -AGMAASPEMMGLGDVKLTPATKMNNKADG--TPKTESKS---------------------------------------- -------------KKSSSST------------------------------------------------------------ -----TTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAAD--SKKSQPKIQPPSPAGS------------ -----------------GSMQGPQTPQST-SSSMAEG-GDLKPPTPASTPHSQIPPLPGMS------------------- --------------------RSNSVGIQDAFNDGSDSTFQKRNSM----------TPNP-GYQPSMNTSDMMGRMS-YEP NKDPYGSMRKA--PGSDPFMSSGQGPNGGMGD----------PYSRAAGPGLGNVAMGPRQHYPYG-------------- ------GPYDRV-RTEPGIGPEGNMS-TGAPQPN-LMPSNPDSGMYSPSRYPPQQQQQQQR-----------HDSYGNQF STQGTPSGSP-FPSQQTTMYQ-QQQQ-NYKRPMDGTYGPPAKRHEG----EMYSVPYSTGQ-GQPQQQQLPPAQPQPAS- --------QQQAAQPSPQ-QDVYNQYGNAYPATATAATERRPA--GGPQNQFPFQFGRDRVSAPPGTNAQQNMP-QMMGG PIQAS-AEVAQQGTMWQGRNDMTY-NYANRQSTGSAP-QGPAYHGVN-RTDEMLHTDQRANHEGPWPSH-GTRQPP--YG PSAPVPPMTRPPP-SNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKS-PFLHS--GMKMQKAGPPVPASHIAPAPVQP PM------------------------------------------IRRDITFPPGSVEATQPVL-KQRRRLTMKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLS-QL--PGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLL DPG---RFSKVSSPAPMEGGEEEEELLGPK-------------------------------------------------- ---------LEEEEEEEVVE------------------------------------NDEEIAFSGKDKPASENS-----E EKLISKFDKLPVKIVQKN--DPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKTELLLSRPHAPCPPAPRK HVTTAEGTPGTTDQE----------------------------------------------------------------- -----------------------------------------GPPPDGPPEKRITATMDDMLSTRSSTLTE----DGA--- ---------------KSSEAIKESSKFPFGINPAQSHRN----------------------------------------- ------------------------------------------------------------IKILEDEPHSKDETPLCTLL DWQDSLP---------------------------GLLLILGKLILL--------HHNHPERKQAPLTYEKE--------- -------EEQDQGVSCNKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPE-SICLPVLDGLLHWAVCPSAEAQDPFSTL GPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIA VQKGSIGNLLGFLEDSLAATQFQQSQASLLH-----------------------------------------MQN-PPFE PTSVDMMR------------------------------------------------------------------------ ------------------------------RAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Macaca_mulatta_ARID1A -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MAAQV APAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGG GGAGGGGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAP---PHSAAAALPPPAYGFGQPYGRSPSAVA AAAAAVFHQQHGGQQSPGLAALQSGG-GGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGS G-AAAAPGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGG- PQDGGAGKGPADMASQCWGAAAAAAAAAAAAAASGGAQQRSHHAPMSPGSS---------GGGGQPLARTP--QPSSPMD QMGKMRPQPYGGT---------NPYSQQ--QGPPSGP--QQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQ-- -------------IPPYGQQGPSGYGQQGQTPYYNQ--QSPHPQQQQ-----PPYSQQPPSQTPHA--QPSYQQQP--QS QPPQLQSSQ--TPYSQQPSQPPHQQSPTPYPSQ-QSTTQQH-----------PQSQPSYSQPQAQSPYQQQQP------- ----------------QQPAPSTLSQQ------------AAYPQPQSQ----------------QSQQTAYSQQRFPPPQ E--LSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLP--------------DLSGSIDDLPMGTEGALSPGVSTSG --------------ISSSQGEQ---SNPAQ-SPFSPHTSPHLPGIR----------GPSPSPVGSPASVAQSR-----SG PLSPAAVPGNQMPPRPPSGQSDSI------------------------------------MHPSMNQSSIAQDR---GYM QRNPQMPQYSSP----QPGSALSPRQPSGGQIHTGMGSYQ-QNSMGSYGPQGGQYGPQGG-----------------YPR QPNYNALP-NANYPS--AGMAGGINPMGAGGQMHGQPGIPPYGTLPPGR-MSHASMGNRPYGPN------------MANM PPQVGSGMCPP-PGGMNRKTQETAVAMHVAANS--IQNRPPG-------------------------------------- -----------------YPNMN-QGG-MMGTGPPYGQGINSMAGMINPQG-PPYSMGGTMANNS---------------- -AGMAASPEMMGLGDVKLTPATKMNNKADG--TPKTESKS---------------------------------------- -------------KKSSSST------------------------------------------------------------ -----TTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAAD--SKKSQPKIQPPSPAGS------------ -----------------GSMQGPQTPQST-SSSMAEG-GDLKPPTPASTPHSQIPPLPGMS------------------- --------------------RSNSVGIQDAFNDGSDSTFQKRNSM----------TPNP-GYQPSMNTSDMMGRMS-YEP NKDPYGSMRKA--PGSDPFMSSGQGPNGGMGD----------PYSRAAGPGLGNVAMGPRQHYPYG-------------- ------GPYDRV-RTEPGIGPEGNMS-TGAPQPN-LMPSNPDSGMYSPSRYPPQQQQQQQR-----------HDSYGNQF STQGTPSGSP-FPSQQTTMYQ-QQQQ-NYKRPMDGTYGPPAKRHEG----EMYSVPYSTGQ-GQPQQQQLPPAQPQPAS- --------QQQAAQPSPQ-QDVYNQYGNAYPATATAATERRPA--GGPQNQFPFQFGRDRVSAPPGTNAQQNMPPQMMGG PIQAS-AEVAQQGTMWQGRNDMTY-NYANRQSTGSAP-QGPAYHGVN-RTDEMLHTDQRANHEGPWPSH-GTRQPP--YG PSAPVPPMTRPPP-SNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKS-PFLHS--GMKMQKAGPPVPASHIAPAPVQP PM------------------------------------------IRRDITFPPGSVEATQPVL-KQRRRLTMKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLS-QL--PGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLL DPG---RFSKVSSPAPMEGGEEEEELLGPK-------------------------------------------------- ---------LEEEEEEEVVE------------------------------------NDEEIAFSGKDKPASENS-----E EKLISKFDKLPVKIVQKN--DPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKTELLPSRPHAPCPPAPRK HVTTAEGTPGTTDQE----------------------------------------------------------------- -----------------------------------------GPPPDGPPEKRITATMDDMLSTRSSTLTE----DGA--- ---------------KSSEAIKESSKFPFGISPAQSHRN----------------------------------------- ------------------------------------------------------------IKILEDEPHSKDETPLCTLL DWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILL--------HHKHPERKQAPLTYEKE--------- -------EEQDQGVSCNKVEWWWDCLEMLRENTLVTLANISG-------------------------------------- ----------------------------------------LYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIA VQKGSIGNLLGFLEDSLAATQFQQSQASLLH-----------------------------------------MQN-PPFE PTSVDMMR------------------------------------------------------------------------ ------------------------------RAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Mus_musculus_ARID1A -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MAAQ VAPAAASSLGNPPPPPSELKKAEQQQREEAG-GEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGG GGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLPEPPGGGGGGGSSSSDGVGAPPHSAAAALPPPAYGFGQAYGRSPSAVA AAAAAVFHQQHGGQQSPGLAAL-QSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPPQAYALSSPRGGT-PG SGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGG- PQDGGAGKGPADMASQCWG--AAAAAAAAAAAVSGGAQQRSHHAPMSPGSS---------GGGGQPLARTP--QSSSPMD QMGKMRPQPYGGT---------NPYSQQ--QGPPSGP--QQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQ-- -------------IPPYGQQGPSAYGQQGQTPYYNQ--QSPHPQQQ------PPYAQQPPSQTPHA--QPSYQQQP--QT QQPQLQSSQ--PPYSQQPSQPPHQQSPTPYPSQ-QSTTQQH-----------PQSQPPYSQPQAQSPYQQQQP------- ----------------QQPASSSLSQQ------------AAYPQPQPQ----------------QSQQTAYSQQRFPPPQ E--LSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLP--------------DLSGSIDDLPMGTEGALSPGVSTSG --------------ISSSQGEQ---SNPAQ-SPFSPHTSPHLPGIR----------GPSPSPVGSPASVAQSR-----SG PLSPAAVPGNQMPPRPPSGQSDSI------------------------------------MHPSMNQSSIAQDR---GYM QRNPQMPQYTSP----QPGSALSPRQPSGGQMHSGVGSYQ-QNSMGSYGPQGSQYGPQGG-----------------YPR QPNYNALP-NANYPN--AGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGR-MAHASMGNRPYGPN------------MANM PPQVGSGMCPP-PGGMNRKTQESAVAMHVAANS--IQNRPPG-------------------------------------- -----------------YPNMN-QGG-MMGTGPPYGQGINSMAGMINPQG-PPYPMGGTMANNS---------------- -AGMAASPEMMGLGDVKLTPATKMNNKADG--TPKTESKS---------------------------------------- -------------KKSSSST------------------------------------------------------------ -----TTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAAD--SKKSQPKIQPPSPAGS------------ -----------------GSMQGPQTPQST-SSSMAEG-GDLKPPTPASTPHSQIPPLPGMS------------------- --------------------RSNSVGIQDAFPDGSDPTFQKRNSM----------TPNP-GYQPSMNTSDMMGRMS-YEP NKDPYGSMRKA--PGSDPFMSSGQGPNGGMGD----------PYSRAAGPGLGSVAMGPRQHYPYG-------------- ------GPYDRV-RTEPGIGPEGNMG-TGAPQPN-LMPSTPDSGMYSPSRYPPQQQQQQQQQ----------HDSYGNQF STQGTPSSSP-FPSQQTTMYQ-QQQQ-NYKRPMDGTYGPPAKRHEG----EMYSVPYSAGQ-GQPQQQQLPAAQSQPAS- --------QPQAAQPSPQ-QDVYNQYSNAYPASATAATDRRPA--GGPQNQFPFQFGRDRVSAPPGSSAQQNMPPQMMGG PIQAS-AEVAQQGTMWQGRNDMTY-NYANRQNTGSAT-QGPAYHGVN-RTDEMLHTDQRANHEGPWPSH-GTRQPP--YG PSAPVPPMTRPPP-SNYQPPPSMPNHIPQVSSPAPLPRPMENRTSPSKS-PFLHS--GMKMQKAGPPVPASHIAPTPVQP PM------------------------------------------IRRDITFPPGSVEATQPVL-KQRRRLTMKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLS-QL--PGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLL DPG---RFTKVYSPAHTE-EEEEE-HLDPK-------------------------------------------------- ---------LEEEEEEGVG-------------------------------------NDEEMAFLGKDKPSSENN-----E EKLVSKFDKLPVKIVQRN--DPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRK HLTTVEGTPGTTEQE----------------------------------------------------------------- -----------------------------------------GPPPDGLPEKRITATMDDMLSTRSSTLTD----EGA--- ---------------KSAEATKESSKFPFGISPAQSHRN----------------------------------------- ------------------------------------------------------------IKILEDEPHSKDETPLCTLL DWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILL--------HHKHPERKQAPLTYEKE--------- -------EEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPE-SICLPVLDGLLHWAVCPSAEAQDPFSTL GPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIA VQKGSIGNLLGFLEDSLAATQFQQSQASLLH-----------------------------------------MQN-PPFE PTSVDMMR------------------------------------------------------------------------ ------------------------------RAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Rattus_norvegicus_ARID1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGG- PQDGGAGKGPADMASQCWG--AAAAAAAAAAAS-GGAQQRSHHAPMSPGSS---------GGGGQPLARTP--QSSSPMD QMGKMRPQPYGGT---------NPYSQQ--QGPPSGP--QQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQ-- -------------IPPYGQQGPSAYGQQGQTPYYNQ--QSPHPQQQQQ----PPYSQQPPSQTPHA--QPSYQQQP--QT QQPQLQSSQ--PPYSQQPSQPPHQQSQTPYPSQ-QSTTQQH-----------PQSQPPYSQPQAQAPYQQQQP------- ----------------QQPASSTLSQQ------------AAYPQPQPQ----------------QSQQTAYSQQRFPPPQ E--LSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLP--------------DLSGSIDDLPMGTEGALSPGVSTSG --------------ISSSQGEQ---SNPAQ-SPFSPHTSPHLPGIR----------GPSPSPVGSPASVAQSR-----SG PLSPAAVPGNQMPPRPPSGQSDSI------------------------------------MHPSMNQSSIAQDR---GYM QRNPQMPQYTSP----QPGSALSPRQPSGGQMHSGMGSYQ-QNSMGSYGPQGSQYGPQGG-----------------YPR QPNYNALP-NANYPS--AGMAGSMNPLGAGGQMHGQPGIPPYGTLPPGR-MTHASMGNRPYGPN------------MANM PPQVGSGMCPP-PGGMNRKTQESAVAMHVAANS--IQNRPPG-------------------------------------- -----------------YPNMN-QGG-IMGTGPPYGQGINSMAGMINPQG-PPYPMGGTMANNS---------------- -AGMAASPEMMGLGDVKLTPATKMNNKADG--TPKTESKS---------------------------------------- -------------KKSSSST------------------------------------------------------------ -----TTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAAD--SKKSQPKIQPPSPAGS------------ -----------------GSMQGPQTPQST-SSSMAEG-GDLKPPTPASTPHSQIPPLPGM-------------------- --------------------RSNSVGIQDAFPDGSEPTFQKRNSM----------TPNP-GYQPSMNTSDMMGRMS-YEP NKDPYGGMRKA--PGSDPFMSSGQGPNGGMGD----------PYSRAAGPGLGNVAMGPRQHYPYG-------------- ------GPYDRV-RTEPGIGPEGNMG-TGAPQPN-LMPSTPDSGMYSPSRYPPQQQQQQQQQQQQQQQQQQRHDSYGNQF STQGTPSSSP-FPSQQTTMYQ-QQQQQNYKRPMDGTYGPPAKRHEG----ELYSVPYSTGQ-GQPQQQQLPAAQSQSAS- --------QPQAAQPSPQ-QDVYNQYSNAYPATATAATERRPA--GGPQNQFPFQFGRDRVSAPPGSNAQQNMPPQMMGG PIQAS-AEVAQQGTMWQGRNDMTY-NYANRQNTGSAP-QGPAYHGVN-RTDEMLHTDQRANHEGPWPSH-GTRQPP--YG PSAPVPPMTRPPP-SNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKS-PFLHS--GMKMQKAGPPVPASHIAPTPVQP PM------------------------------------------IRRDITFPPGSVEATQPVL-KQRRRLTMKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLS-QL--PGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLL DPG---RLTKVSSPAPTE-EEEEEEHVDPK-------------------------------------------------- ---------LEEEEEEGVE-------------------------------------NDEEMAFLGKDKPPSEKS-----E EKLVSKFDKLPVKIVQKN--DPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPCVPSPVPPRK HVTTVEGTPGTTEQE----------------------------------------------------------------- -----------------------------------------GPPPDGLPEKRITATMDDMLSTRSSTLTD----EGT--- ---------------KSTEANKESSKFPFGISPAQSHRN----------------------------------------- ------------------------------------------------------------IKILEDEPHSKDETPLCTLL DWQDSLAKRCVCVSNAIRSLSFVPGNDFEMSKHPGLLLILGKLILL--------HHKHPERKQAPLTYEKE--------- -------EEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPE-SICLPVLDGLLHWAVCPSAEAQDPFSTL GPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIA VQKGSIGNLLGFLEDSLAATQFQQSQASLLH-----------------------------------------MQS-PPFE PTSVDMMR------------------------------------------------------------------------ ------------------------------RAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Monodelphis_domestica_ARID1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MGGGGPAATGGGTPQPTATPTLNQLLTSPSSARGYPGYPGSDYGGGG PQDGGATKGPADLASQYAG-----SGQAWGSAASGAGQQRSHHAPMSPGSSS--------GGAGQPLTRTP--QPSSPMD QMGKMRPQPYGGS---------NPYSQQ--QGPPSGP--QQGHGYPGQPYGSQTPQRYPMTMQGRAQSTMGSLSYAQQ-- -------------IPPYGQQGPSGYGQQGQSPYYNQ--QSPHPQQPP-------YSQAPPSQTPHA--QPSYPQQP--QS QPPQLQATQ--PPYSQQPSQPSHQQSPSPYPQQ-QSTAQQH-----------PQSQPPYSQQQAQSPYQQQPP------- ----------------QQTASAALSQQ------------SAYPQSQAQ----------------QPQQTAYSQQRFPPPQ E--LSQDSFGSQASSAPSMASSKGGQEDMNLSLQSRPSSLP--------------DLSGSIDDLPMGTEGALSPGVSTSG --------------ISSSQGEQ---SNPAQ-SPFSPHTSPHLPGIR----------GPSPSPVGSPASVAQSR-----SG PLSPAAVPGTQMPPRPPSGQSDSI------------------------------------MHPSMNQSSIAQDR---GYM QRNPQMPQYSSP----QPGSALSPRQSSG-QMHAGMGSY--QNSMGSYGPQGAQYGPQGG-----------------YPR QPNYNTLP-NANYPS--AGMAGSMNPMGAGAQMHGQTGMPPYSGLPPGR-MSHASMGSRPYGPN------------MANM PPQVGSGMCPP-PGGMNRKAQETAVAMHVAANS--IQNRPPG-------------------------------------- -----------------YPNMN-QGG-MMGTGPPYGQGLNSMAGMINPQG-PPYPMGGNIANNS---------------- -AGMAASPEMMGLGEVKLTPATKMNNKADG--TPKPESKS---------------------------------------- -------------KKSSSST------------------------------------------------------------ -----TTNEKITKLYELGGEPERKIWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAAD--SKKSQPKIQPPSPAGS------------ -----------------GSMQGPQTPQST-SSSMAEG-GDLKPPTPASTPHSQMPPLPGIR------------------- ---------------------SNSVGIQDAFADGSDPTFQKRNSM----------TPNP-GYQPSMNTSDMMGRMS-YEP NKDPYGSMRKA--PGNDPFVSSGQGPNSGMGD----------PYNRATGPGLGNMAMGQRQHYPYG-------------- ------GPYDRV-RAESGLGPEGNMG-TGAPQPN-LLPSNPDSGMYSPSRYPPQQQQQQQQQQQQQQQQ--RHDSYGNQF STQGTPSSSP-FPSQQTTMYQ-QQQQ-NYKRPMDGTYGPPAKRHEG----EMYSVPYSSGQ-GQPPQQQLPPAQPQPAS- --------QQQPAQPSPQ-QDVYNQYGNAYP---TAGADRRPA--GGPQNQFPFQFGRDRVSAPPGSNAQQSMPPQMMGG PMQPT-TEGPQQGTMWQGRNDMGY-NYPNRQNAGSAP-QGPAYHGVN-RTDEMLHTDQRVNHEGPWPSH-GTRQPP--YG PSAPVPPMTRPPQ-SNYQPPPSMQNHIPQVSSPAPLRPPLENRTSPSKS-PFLHS--GMKMQKAGPPVPASHIAPAPVQP PL------------------------------------------IRRDITFPPGSVEATQPVL-KPRRRLTTKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLG-QL--PGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLL DPE---RFSKASSPSPGEGEEEE-ELLSPK-------------------------------------------------- ---------MEEEEE---EE------------------------------------EEEEAAFAGKDKVFSESS-----E EKLVSKFDKLPVKIVQKN--DPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKMELPLTQAREPLPVAPQK RVPAAEGTPGMKDRE----------------------------------------------------------------- -----------------------------------------GPLPDGPSEKRITATMDDMLSSRPSTLSD----EGA--- ---------------KNTETPKESGKFPFGMNPVQSHRN----------------------------------------- ------------------------------------------------------------IKILEDEPHSKDETPLCTLL DWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILL--------HHKHPERKQAPLTYEKE--------- -------EEQDQGVSCNKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPE-SICLPVLDGLLHWAVCPSAEAQDPFPTL GPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIA VQKGSIGNLLGFLEDSLAATQFQQSQASLLH-----------------------------------------MQN-PPFE PTSVDMMR------------------------------------------------------------------------ ------------------------------RAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Gallus_gallus_ARID1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------MPKQADGKSSF--SPSSPMD QMGKMRPQPYGGN---------NPYTQQ--QGPQAGP--QQGHGYPGQPYGPQTPQRYPMGMQSRTQSTMGSISYAQQ-- -------------IPPYGQQGPNAYGQQSQTPYYNQ--QSPHPQQQ-----QPPYSQQTPSQTPHS--QPSYQQQQQPQS QAPQLQTSQ--PAYSQQQSQPPHQQSPTPYPQQ-QSTAQQH-----------QQNQPPYSQQQSQSPYQQQQQ------- ---------------TQQTASSALSQQS-----------SSYPQSQPQ----------------QQQ-SAYSQQRFPPPQ E--LSQESFGSQTSSAPSMASSKG-QEDMNLNIQSRPSSLP--------------DLSGSIDDLPMGTEGALSPGVSTSG --------------ISSSQGEQ---SNPAQ-SPFSPHTSPHLPGIR----------GPSPSPVGSPASVAQSR-----SG PLSPAAVPGNQMPPRPPSGQSDSI------------------------------------MHPSMNQSSIAQDR---AFA SLSADVSCPSS--------VTLSFKRR-GGHNNIGWHLLI-WALMGSSG--------KSS-----------------WNS VLKFTAVYFNCPFQS--SCSVAYQNAMRATGLLIIFCLMTAKRSIPKHR-SRHEIKREKP--LN------------MGGT VLRIG------------------KKAVLLLKCT-VLQY?----------------------------------------- -----------------------QGG-MMGTGPPYGQGINSMAGMINPQG-PPYPMGGNMANNS---------------- -AGMAASPEMMGLADVKLTPATKMNNKADG--TPKAESKS---------------------------------------- -------------KKSSSST------------------------------------------------------------ -----TTNEKITKLYELGGEPERKIWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYISVKEIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAAD--SKKSQTKIQPPSPAGS------------ -----------------GSMQGPQTPQST-SSSMAEG-GDLKPPTPASTPHSQMPPLPG-I------------------- -------------------SRSNSVGLQDAFTDGSDPTFQKRNSM----------TPNP-GYQPSMNTSDMMGRMS-YEP NKDPYSSMRKA--PGSDPFMSSGQGPNSGMGD----------PYNRAAGPGMGNMAMGQRPHYPYG-------------- ------GPYDRV-RTEPGMGPEGNLA-AGTPQPN-IMPSTSESGMYSPSRYPQQQQQQQRFV----------HDSYGNQF STQGTSSGSP-FPSQQTTMYQ-QQQQ-NYKRPMDGSYGPPAKRHEG----EMYNVPYSAGQ-GQT-QQQLPPAQTQQPS- --------QQQAAQPSPQ-QDLYNQYGSTYP-----AADRRSA--GGPQNQFPFQFGRDRVSAPPGSNAQQNMPPQMMGG PIQSA-PEGPQQGAMWQGRNEIGY-SYPNRQSTGSAP-QGPAYHGVT-RTDDILHSEQRVNHEGPWPSH-GNRQPP--YG PSAPVPPMTRPPQ-SNYQTPPSMQNHIPQVSSPAPLPRPLENRTSPSKS-PFLHS--GMKMQKAGPPVPASHITPAAVQP PM------------------------------------------IRRDITFPPGSVEATQPVL-KQRRRLTAKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLS-QL--PGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLL DPQ---RFCRSSASSHEEGEEDEELRSLNN-------------------------------------------------- ---------EEEEDDEE----------------------------------------EEEAAFSSKDKAPLECS-----E EKLVSKFDKLPIKIVQKN--DPFVVDYSDKLGRVQEFESGLLHWRIGGGDTTEHIQTHFESKMELPMIHKRASCN-SVSR KRAAAESNPSTREGE----------------------------------------------------------------- -----------------------------------------ALPSDSSSEKRITATMDDMLSARPSSLSG--EEEEA--- ---------------KASETEKES-KFPFGISPAQSHRN----------------------------------------- ------------------------------------------------------------IKILEDEPHSKDETPLCTIQ DWQDSLAKRCICVSNIIRSLSFVPGNDFEMSKHPGLLLILGKLILL--------HHKHPERKQAPLTYEKE--------- -------EEQDQGVSCNKVEWWWDCLEVLRENTLVTLANISGQLDLSPYPE-SICLPILDGLLHWAVCPSAEAQDPFPTL GPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTLVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIA VQKGSIGNLLGFLEDSLAATQFQQSQAGLMH-----------------------------------------MQN-APFE STSVDMMR------------------------------------------------------------------------ ------------------------------RAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Xenopus_tropicalis_ARID1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------GPPQPAAATPTLNQLLTAPSPGRGYPAYPGGDYPDQ- ------------------------HKGAEGYTAGWAAGQRGVHPPGSPGSS------------GQGLPRTP--QPATPMD QMGKMRPQPYGSS---------NPYSQQ--QGAQQG-----HSGYPVQPYSSQSPQRYPMSMQGRPQGGMS-MQYGQQ-- -------------MSPYTQQGPGSYSQQSQSPYYNQ--QSLHPPQQPQT--TPPQTQYSQQQSGPQ--SYSQQQAP--SS QPTPTQSGQ--PTFTQQQS-----PSPSPYTQQ----------------------QGAPTSSQSQSPYTQQTG------- -------------------QYTSTQQQV-----------SSYPSTGAQ----------------QSG--TYSQQRFPPPQ E--LSQDSFTSQASSTPSLGSSKG-QDDLSMGMQPRPSSLP--------------DLSGSIDDLPMGAEGALSPGVSTSG --------------ISSSQGEQ---SNPAQ-SPFSPHTSPHLPGIR----------GPSPSPVGSPASVAPSR-----SG PLSPTAVPGTQMPPRPPSGQSDGL------------------------------------IHPTMNQASLGQERA-TGYM QRNAQIPQYGSP----QPGPALSPRQSTAAQMHSGMGPYQ-QNSMGSYGPQGGQYGPQGG-----------------YPR QPNYNTMP-NAGYS------AGGMTPLVAGGQMHGQGGMPQY----TGR-MGHSGMGNRPYGPN------------MGSM PPQVASGMCPP-PAGMNRKAQE-AAGMHATPNS--LQSRSPG-------------------------------------- -----------------YPNMN-QGG-MMGSGTAYGQGMNSMAAIMNTQG-NPY-MSGNMVNNSG--------------- -KGMAGSPDLMGLPDVKLTPTPKMNNKADG--TPKSETKS---------------------------------------- -------------KKSSSST------------------------------------------------------------ -----TTNEKITKLYELGVEPDRKMWVDRYLSFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPDIFASAE--SKK-QAKIQPPSPAGS------------ -----------------GSMQGPQTPQST-SSSMAEG-GDLKPPTPASTPHSHMPPMPGMS------------------- --------------------RNNSVGLQEAY-DGSDPSYQKRNSM----------TPNP-GYQ-----ADMMGRMP-YET GKDPYGNMRKG--PGADPFMPSGQGPSGTIGD----------PYSRGTGPGMP--SLGQRQHYPYG-------------- -------GYDRV-RGEPGLGPEGGMG-SGGNQQN-MMPSNTDSGMYSPGRYPQQSSR---------------HDSYGNQY PTQGTAAGSP-YPSQQNPLYQ-QQVK-NYKRPMDGSYGPSPKRHEG----ELYGGPYSGGQAGQNQQQPQPPPQQQQPPG SGAPPTPGQPPAATNAQQPQDPYGQYGGSYP----QGTERRPV--ASGQNQFPFQFGRERVSAAPSSNSQPPLPSSVMS- ---NS-GEGNQQGAMWQGRNDMSY-NYQGRPGPPPANTQGQGYHSVPPRGEDMMHSDQRLSHEGQWQPH-VNRQQP--PY VPAPGPAMTRAPPQSGYQASPSMPNHLPQVPSPA-TPRPLEAHTSPSKS-PFLK------MQKAGPPVPASHIVPTPTQP PL------------------------------------------IRRDITFPPGSVEATPPLL-KPRRRLTAKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLS-QL--PGLLELLVEYFRRCLIEIFGILREYEVGEHAQKTLL QPFPSDSSSLLSGDAEMVDGDDHQSVTDGD-------------------------------------------------- ---------PQSEDEEGLEE---------------------------------------RKAYN--TPFSSNED-----T QQQSSKFDRLPIKVVSKE--DPFVLDCSHQLGRLQEFESGLLHWRIGGGDTTEHIQTHFERRPEPPPRR----RPPVKRR ----------SREQQ----------------------------------------------------------------- -----------------------------------------IPAAEDT-----TPTIDDVLCARPSSLSQ---------- ---------------ETGETTEEDCEFSLGGSPPPRNRHG---------------------------------------- ------------------------------------------------------------MKILEDEPRSKDETPLCTLE DWQDALSRRCVCISNILRSLSFVPGNDLEMSKHPGLLLLLGKLVLL--------HHKHPERKQAPLTYEKE--------- -------EERDQGVSCNKAEWWWDCLEMLRENTLVTLANISGQLDLSPYPE-SICLPILDGLLHWAVCPSAEAQDPFVTL GPNAVLSPQRLVLEALSKLSIQDSNVDLILATPPFSRLEKLYGTLVRFLSDRKNHVCREMAVVLLANLAQGDTLAARAIA LQKGSIGNLLGFLEDSLAATQFQQSQAAHLH-----------------------------------------GSS-APFE PTSTDMMR------------------------------------------------------------------------ ------------------------------RASRALLALAKVEENHPEFTLYEARLLDISVSPLMNCSVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Takifugu_rubripes_ARID1A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MAAQVASVATLNTSPPSELKKPDRDSQEESVPGEKQHENKEPGP------------------------DGGSPGQKELQD GTDAGNAGGGGDPDMKNGNGNLSRVNNNSSIQNDSGGPEGNNHPG-------MGHHHPGPFPPPPYGYNQHYNRAP---- -------FHQHGGQQSPGMAAAS-----GPGMMDPYPP-NSHEHGYPN-HYNNYSPYPNRTSYQGQGYG----------- AMNSPRNN-QPPAAGGQPGKQQ---PAGGTTAMAASYNNQRFNMGTQQPTSTPTLNQLLTSPSSARSYPNYPQGDYNNQ- ---EGANKGAGDMGSSQ-----------YGGVHPGWQQRTHHPPPMSPGNT------------GQPPNRNQ--QPPSPMD QVGKMRGQPYGGP---------NPYSQQ-QQGPPAGPGPQQGGSYPGQGYGPPGPQRYPMGMQSRTPGGMGSMQYGQQ-- -------------MSAYGQQGPGGYGQQSQA-YYGQHGPPPLPGQQQQQQPSYPGQPQSQGPHGPAPGQPPYSQPPHSQQ GQPPYVP----PQQQQQQQPQQQQQGPGPQSQQGPQGPG-------------QPPQQPPPPQQQQGPPQPQQQQQQ---- ------------QQPQQQPGGPTPQAQP---------PPGHGQQGQPSPYSQTPPL--------PQQQQQSPYQRFPPPP QE-LSQDSFSSQSNASASNQAMASSKSSQEDSMQTRPSSLP--------------GQAGSIIDLPLP------------- --------------LNSSESHF---CNPAQPSPAQRRSAPAVP--R----------GVLRSRVREPASEQ-QR-----SA PVTPSGVSPSGHVPKIATGAVSSA------------------------------------KPPASGLQPVCE-----LYM R-NPQMPPYGSPGHPGQPGSALSPRQSSG-QMHSGMGPYPQNNSMGNYGPQSGQYGPQG------------------YPR QPGYTGMP-NANYPSGP-GMGGTMNPMPS------QGSGGPYGSIPPGR-LGPGQMGARPYGPG--------MGTNMGGM HPQVGSGMCPP-P-GMNRK-DGGPSMHHGPTNS--IHNRPPG-------------------------------------- -----------------YPNMS-QG--MMGAGSPYGPGMNSMHGMMNQGGPGPYPMGTNMANNTP--------------- --GMPPNSEFG-M--EKMNPAQKINNKVEG--TPKTESK----------------------------------------- -------------KKSSSST------------------------------------------------------------ -----ITSEKITRLYDLGQEPERKMWVDQYLAFAEEKAMGMSNLPAVGRKPLDLFRLYVSVKQIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPDFFNTD---TKKSQPKIQPPSPAGS------------ -----------------GSLQGPQTPQST-SSSMAEG-GDLKPPTPASTPHTQMPPMPGAR------------------- -------------------Y-KSSVNLQDPFADGGDPAFSRRNAM----------TPNSQGYQPSMGGPEMMGRMGPYES NKDPFGGMRKV--PAGEQFMQP--APNSGMGE----------QYNRGPPGPMANMQMGQRQQYPYG-------------- --------YDRS-RQESGMGPDGSMG-PGAPQPN-MMPSGADTGMYSPSRPPPQQRSVLA----------FRHDSYSNQF PGQGAPPGGP-YPNQQPGMYPQQQ--PNYKRPVDGGYGPPAKRHEG----EMYNVPYSGQQ---------QPGP------ ----------QSSGPQGQ-QDMYNQYN---A---YPGGDRRP---PGPQNQFPFPFGRERGPSSGGPNSQSPMPPQMMAS SMPSG-PDGPQ-GPMWQSRNEMGYPNYPNRQGPP-VPGQGPGYHGMN-RSEEMMSSDQRMNHEGQWPSHVNQRQPP--FG PGGSGPPMTRPLP-STYQTS---QNHIPQVSSPAPMPRPMESRTSPSKS-PYMHP--GIKVQKAGPPVPASHIGQAPVQQ PM------------------------------------------IRRDVAFPPGSVEASQPHL-KPRRRLTMKDIAGTPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSISTFNLC-QL--PGFLELVVEYFRRCLIEIFGILKEYEVGDPGQRTLI DPN----AAEDSDNDLPLPEGDGMDLVEDD-------------------------------------------------- ---------EEDEEVEES--------------------------------------KEPNTSTSGSSQDPGLHS----ER PRQASKFDKLPLKVVRKK--NPFLVNHSSKLGQRQNFDSGLIHWSIGGGDTTDHIQTHFESRADHLKQRKRKPAATESRK KAQVTEAVTENS-------------------------------------------------------------------- ---------------------------------------------EKKAPPPLIATIDDVLSARPGSITEEAVRGG---- -----------------AEEQKENGKYLFSINPELQSRR----------------------------------------- -----------------------------------------------------------NVKILEDEPHSKDETPLSTLS DWQDSLARRCICVSNIVRSLSFVPGNDLEMSKHPGLLLLLGRLVLL--------HHRHPERKQAPVTYEKE--------- -------EEEDEGVSCERDEWWWDCLEVLRENCLVTLANISGQLDLSIYSE-SICLPLLDGLLHWAVCPSAEALDPFPTL GPHGSLSPHRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYGSLVRLVGERKVAVCREMAVVLLANLAQGDSLAARAIA VQKGSVGNLLGFLEDSLAATQYQQSQSSLLQ-----------------------------------------MQGGPQFE PTSVDMMR------------------------------------------------------------------------ ------------------------------RAARALHALAKVEENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Takifugu_rubripes_ARID1A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MAAQVASATTLNTSPPSELKKPDRDPKEESVPGEKQSDKKQPGL------------------------DSGSPGRGDLQD GSDSGNAGGGGEPEMKNGNGNPPRANNNN--QNDSAGPEGNNHPG-------FVHHHGPAFPPPSYGYSQHYGRAP---- -------FHQHGGQQSPGMAAAAGPVVQSGNIMDPYQP-NSHDHGFSNHQFNSYSPFPNRTPYPGQAY------------ AMNSPRSN-QAPTAGGQPANVKQPPPSGGPTAMVGSYNNQRYNIGNPQPTSTPTLNKLLTSPSSTRAYSNYPSSDYSSQ- ---EGASKGPSDMGSSG-L---------YGGSNPAWQQRSHLPSPMSPGSA------------GQPLVRNQ---PPGSMD PMAKMRGQPYGAG---------SPYSQQSQQGPPTVP--QQGPGYPGQGYGSPGQQRYPVGMQGRSPGGMGGMPYAPQ-- -------------MGSYGQQGPGGYGSQGQAPYYGQPSQAPHTGQQQ-----TPYSPSPQGQPSG---QTPYPGQPHPP- STASHGQA---GPPYQQPHMPPQSQGPLSAPAQGSPQ-----------------AQPPYSQASGPQSGQSMYG------- -------------QQQQQPQSQAPPQPT---------GHSQHPQGQPVAYPQ------------QQQAQQSPYQRFPPPQ QE-VSQDSF--QSNVPPSTQP----KSGTED-SQGRPSSLP--------------DLSGSIDDLPTGTEGALSPGVSTSG --------------VSSNQGEQ---SNQAQ-SPFSPHTSPHLPGIR----------GPSPSPAGSPASSSTPR-----TG PLSPANMPGTQMPPRPSSVQSDGS------------------------------------LHPAMSQSPMAQDR---GFM QRNPQMPPYGSP----QSASALSPRQSSGGQMHPGMGPYQQNNSMGVYAQQGGQYGPQG------------------YPR QPGYGSMP-NANYPG--VGMG-PMNPMTG------QGAGSPYSGMPPGR-MPPNQMGARPYGPN-----------NMANM PPQVSSGMCPP-P-VMNRKPQDPAAMQHPPSNS--MHNRMPG-------------------------------------- -----------------YHNMS-PG--MMGSGPHYGPPMNSMPGMMNTQGGSPYAIGPNIANNSS--------------- --GMASGP----------EVNNKMNNKVDGNTTPKPEPKA---------------------------------------- -------------KKSNSST------------------------------------------------------------ -----TSNEKITRLYDLGPEPDRKMWVERYLAFVEEKAMGLTNLPAVGRKPLDLFLLYTSVKGFGGMSQVN---KNKKWR DLAASLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPEIFTDN---KKSQPAKVQPPSPAGS------------ -----------------GSLQGPQTPQST-SSSMAEG-GDLKPPTPASTPHTQMPPLPPGS------------------- ---------------------RSSVNLQDPFSEGNDPAF-PRKNL----------TPNS-AYQAGMNTPDMQGRMGTYEP NKDPFGNMRKV----GEQFLPANQGSNSGVGD------QQQ---QQGPPGAMGTMPMGPRQQYPYG-------------- ------PGYDRSTRSEQGMGPEGNMG-SGAPQPNPMMSANTDTGMYSPNRFPPQQSRLVC----------QRHDSYGNQY PGQGTPPTGS-YPNQQPGLYQ----QQSYKRPVDGVY-PPSKRHEA-----EYSGPFHGGQ---------QPPQQQQQQ- --------GGASAPSSGQ-PETYNQFSGGGP---YPGADRRP---TGPGNQFPFPFGRERMQGATGPNAQPNMPPHMM-- --QSG-PEGPQ-GAMWQGPRDINYQNYPGRQGGPGGPPQGPGYPGMN-RSEEIMSTEQRMNHDGQWGGQMGPRQPP--YG PGGPGQAMPRSVQ-ANYQPPQGVQNHIPQVSSPASMPRPMESRTSPSKS-PYMHG--VMKMQKAGPPVPASHIVPPPVQS PL------------------------------------------IRRDMPFPPGSIEASHPVL-KPRRRLTVKDIG-TPE AWRVMMSLKSGLLGESTWALDTINVLLYDDSTISTFDLN-TL--PGLLELVVEYFRRCLIEIFGILKEYEVGDPGQRTLL DPD----ALKSDCDNT-DEEQEAEEMEHGK-------------------------------------------------- ---------EEEEEEEEPD------------------------------------AYGQTRVKEEKEKEQCQDLRDPDER PKQASKFDKFPLKVVRKR--DPFVDGHSNNHGKLQEFDSGLLHWSAGGGDSTDHIQTHFEPCKDFLERRERVTLPPVLLR RQAPEEE--KNTAP------------------------------------------------------------------ ------------------------------------------DKTSPPVHGEEGK----TDP---ETNVIERG------- -----------------VKSHQENNRPI-LSSSILTQKS----------------------------------------- ---------------------------------------------------------EQSSTILEDEPHSKDEGPLIALA DWQDSLARRCICISNIVRSLSFVPGNDHEMSKHPGLLLILGRLILL--------HHRHPERKQAPLTYEKD--------- -------EESDDGVG-QRDEWWWDCLELLRENTLVTLANISGQLDLSLYSE-SICLPLLDGLLHWAVCPSAEAQDPFPTL GPNSTLSPQRLVLETLSKLSIQDNNVDLILATPPFVRLEKLYGNLVRLIGDRKIAVCREMAVVLLANLAQGDTLAARAIA VQKGSVGNLLGFLEDSLAATQLQQSQSSLLH-----------------------------------------LQG-MHFE PTSPDMMR------------------------------------------------------------------------ ------------------------------RAARALHALAKVEENHGEFTLHESRLLDLSVSPLMNSLVSHVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Gasterosteus_aculeatus_ARID1A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------QPPSPMD QVGKMRGQSYGGP---------NPYSQQ-QQGTPTGPGPQQAGPYPGQGYGPPGPQRYPMAMQNRTPGAMGGMQYGQQQG LCILICRGGISCLMSAYGQQGPGGYSQQGQG-YYGQHGAPPHP------------------------------------- -------------------------------------------------------------------------------- --------------------GPPPQAQQ---------PPGHGQQGQPSPYSQTPP------------------------- ------------SSAPPSNQPMASNKSSQEDSMQGRPSSLP--------------DLSGSIDDLPTGTEGALSPGVSTSG --------------VSSSQGEQ---SNPAQ-SPFSPHTSPHLPGIR----------GPSPSPVGSPASVTPSR-----TG PLSPAAVPGNQMPPRPPSVQSDTI------------------------------------MHSSMNQSAMGQER---VYM R-NPQMAPYGSP---GQPGSALSPRQSSGGQMHAGMGPYPQNNSMGNYGPQGGQYGPQG------------------YPR QPAYTGMP-NANYPTGPAGMSGSMNPIPG------QGSGAPYGGIPPGR-IGPTQMGPRPFGPA--------MAANMAGM PLQVASGMVSL-P-AMNRK-EGGSSMHHGLTNS--VHNRPPG-------------------------------------- -----------------YPNMA-QG--MMGTGSPYGPGMNSMHGMMNQGAPGPYPMGANLANNTPVS------------- -LGMAPSSEFG-V--EKMNPTQKINNKMEG--TPKPESK----------------------------------------- -------------KKSSSST------------------------------------------------------------ -----ITNEKITRLYELGPEPERKMWVDRFLAFAEEKAMGMNNLPAVGRKPLDLFRLYVSVKEIGGLTQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPADFFNTD---TKKNQPKIQPPSPAGS------------ -----------------GSLQGPQTPQST-SSSMAES-GDLKPPTPASTPHTQMPPMPGAS------------------- ---------------------RSSVNLQDPFADGVDPAFSRRNAM----------TPNSQGYQPGMGGPEMIARMGPYES NKDPFGGMRK----AGEQFMQP--GPNSGMGE----------QYNRGPPGPMGNMQMGQRQQYPYG-------------- --------YDRR-R----------------------------------------------------------HESFSNQY PGQGAPPGGP-YPNPQPGMYPQQQ--PNYKRPVDGGYGPPAKRHEG----EMYNVSYSGQQ---------QPGP------ ----------QPSGPQGQ-QEIYNQYN---A---YPGGDRRP---PGPQNQFPFPFGRDRVPPSAGPNSQAPMPPQMMSS PMPSG-PDASQ-GPMWQGRNEMGYPNYPNRPGPP-VPGQGPGYHGMN-RSEEMMPSDQRMNHEGQWPGHVNQRQPP--FG PGGSGPPMTRPLP-STYQTS---QNHIPQVSSPTPMPRPMESRTSPSKS-SYMHP--GIKVQKAGPPVPASHIGQAPVQQ PM------------------------------------------IRRDVAFPPGSVEASPPHL-KPRRRLTMKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSITTFNLC-QL--PGFLELVVEYFRRCLIEIFGILKEYEVGDPGQRTLI DPD----AAEDLEDETPLTEGEDMDVDEED-------------------------------------------------- ---------DEDEEPEETKASP----------------------------DTPSLVQEPTTSTSGSSQDPNLHP----EK PRQASKFDKLPIKVVRKK--NPFLVNLSSKLGQRQSFDSGLTHWSIGGGDTTEHIQTHFESRRDLLKQRKCKPTAGAGRK KFQASEAATETA-------------------------------------------------------------------- ---------------------------------------------EKSNGAPVTATIDDVLSARPGSVTEEVVRGG---- -----------------AEEQKENGKYLFSINPDLQSRR----------------------------------------- -----------------------------------------------------------NIKILEDEPHSKDETPLSTLS EWQDSLARRCVCVSNIVRSLSFVPGNDLEMSKHPGLLLLLGRLVLL--------HHRHPERKQAPVTYEKE--------- -------EEEDEGVSCERDEWWWDCLEVLRENCLVTLANISGQLDLSIYPE-SICLPLLDGLLHWAVCPSAEALDPFPTL GPHGSLSPQRLVLETLSKLSIQDNNVDLILATPPFRRLEKLYGSLVRLVGERKVAVCREMAVVLLANLAQGDGLAARAIA VQKGSVGNLLGFLEDSLAATQYQQGQSSLLQ-----------------------------------------MQGGPQFE PTSVDMMR------------------------------------------------------------------------ ------------------------------RAARALHALAKVEENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Gasterosteus_aculeatus_ARID1A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MAAQVA---TLNTSPPSELKKPDRDPKEESVPGDKQSDKKQPSL------------------------DSGSPGRGDLQD GADGGNAGGGGEPEMKNGNGNPPRANNNN--QNDSVGPEGNNHPG-------LVHHHGAAFPPSSYGYSQHYGRGP---- -------FHQHGGQQSPGMAAAG-PVAQSGNMMDPYQA-NSHEHGFSNPQFNNYNPFPNRTPYPGQAY------------ AVNSPRST-QAPTAGGQPASA----PAAGPAAMAGSYSNPRYNIGNPQPTSTPTLNKLLTSPSSTRGYPNYPSNDYGGQ- ---EGASKGPADMGSSG-L---------YGGSTPGWQQRSHHPSSLSPGSA------------GQPLVRSQRVQPPVPMD PMGKMRGQPYGGG---------GPYSQQSQQGPPTGP--QQGPGYPGQGYGPPGPQRFPVGMQGRTPGGMSSMPYGPQ-- -------------MGSYGQQGPGGYGSQGQAPYYGQPGQTPHPSQQQ-----TPYSQPPAGQPGG---QTPYPGQTHPPP TSAPHTQG---GQSYQQPHMPTPSQGPLPGPSQGPPQ-----------------SQPPYSQQQQAQS------------- -------------QPPQQPPG-TQPTPT---------GSACRVPSEPSTATA------------ATSTTVT-VSALPPPQ QQ-VSQDSF--QSNAPPSTQP----KSGPED-SQGRPSSLP--------------DLSGSIDDLPTGAESALSPGVSTSG --------------VSSSQGEQ---SNQAQ-SPFSPHTSPHLPGIR----------GPSPSPAGSPAGASTPR-----TG PLSPANMPGTQMPPRPSSVHSDGS------------------------------------LHPAMSQSPMAQDR---GFM QRNPQMPTYGSP----QSTSALSPRQSSGGQMHPAMGPYQQNNSMGSYGQQGGQYGPQGG-----------------YPR QPGYGNMP-NANYTG--PGIG-PISSMGG------QGGGPPYVGMPPGR-MPPNQMGARPYGPNMGPNMGPNMPPNMGNM PPQVGSGMGPP-P-GMNRKPPDTTALQHPATNS--MHNRMPG-------------------------------------- -----------------YPNMS-QG--MMGSGPPYGPPMNNMPGMMNTQGGSPYPMGPNLANNSS--------------- --GMVPSP----------EVNNKMNNKVDGTITPKPEPKS---------------------------------------- -------------KKSNSST------------------------------------------------------------ -----TTNEKITRLYELGPEPERKMWVDRYLAFVDEKAIGLTNLPAVGRKPLDLFRLYMSVKEIGSMAQVS---KNKKWR DLATSLNVGTS--SSAASSLKKQYIQCLYAFECKIERGEDPPPEIFTDN---KKNQTAKVQPPSPAGS------------ -----------------GSLQGPQTPQST-SSSMAEG-GDLKPPTPASTPHTQMPPMPPGS------------------- ---------------------RNSVNLQDPFAEGSDPAF-PRKNM----------TPNS-AYQPGMNTPDMQGRMGPYEP NKDPFGNMRKV--PVGEHFLPANQGPNSGVVD------QPPPSFNRGPPGAMGTMPMGPRQQFPYG-------------- ------PGYDRS-RPEQGMGPEGNIG-AGAPQPSAMIPANADPGMYSPNRFPPQQPRFDF----------YRHDSYGNQY PGQGTPPTGS-YPNQQPGMYLCLE-QHTYKRPVEGGY-PPSKRHES-----EYSGPFHGG-------------------- ---------GAPAASSGP-QESYNQYSGSGP---FPGADRRP---PGPGNQFPFPFGRERMQVTAAPNAQPNMPPQMM-- --QPG-PDGPQ-GGMWQGPRDMNYQNYPSRQGGPGGPTQGPGYPGMN-RSEE-MSSEQRMNHDGQWGGPMGPRQPP--YG PAGPGQPMPRSVQ-SNYQSLQGVQNHIPQVSSPASMPRPLDSRTSPNKS-LYMHG--VMKMQKAGPPVPASHIVPPAVQS PL------------------------------------------IRRDMPFPPGSTEASHPVL-KPRRRLTVKDIG-TPE AWRVMMSLKSGLLAESTWALDTINILLYDDNSISTFDLN-TL--PGLLELVVEYFRRCLIEIFGILREYEVGDPGQRTLL DPD----ALKRDWSGAEDEELRAKDMEQEE-------------------------------------------------- ---------GDDEDEDEPE------------------------------------PEGPACVKEE-------------ER PKQASKFDKFPLKVVRKK--DPFKTGQSNNHGQLQEFDSGLIHWSAGGGDSTDHIQTHFEPRKDFLEPRQRISVPASLLK RRVPEEVFLENCLP------------------------------------------------------------------ ------------------------------------------TEGEKKANQDEEE----TTSSEKASASLSSGEERKTDS EM--------------VNGSHQDINRPIPFPDIILTHRA----------------------------------------- ---------------------------------------------------------KQTGVILEDEPHSKDEGPLIALA NWQDSLARRCVCVSNIVRSLSFVPGNDHEMSKHPGLLLLLGRLILL--------HHRHPERKQAPLTYEKD--------- -------EDSEEGTG-QRDDWWWDCLALLRENTLVTLANISGQLDLSIYPE-SICLPLLDGLLHWAVCPSAEAQDPFPTL GPHSSLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYGNLVRLIGDRKVAVCREMAVVLLANLAQGDAVAARAVA VQKGSVGNLLGFLEDSLAATQLQQSQSSLLH-----------------------------------------LQG-MHFE PTSPDMMR------------------------------------------------------------------------ ------------------------------RAARALHALAKVEENHSEFTLQESRLLDLSVSPLMNSLVSHVICDVLFLI GQS----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Drosophila_melanogaster_ARID1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------MNEKIKSPQTQQQQQG GAPAPAATPPSAGAAPGAATPPTSGPPTPNNNSNNGSDPSIQQQQQNVAPHPYGAPPPPGSGPGGPPGPDPAAVMHYHHL HQQ-----------QQQHPPPP--------HMQQQQHHGGPAPPPPGGAPEHAPGVKEEYTHLPPPHPH---PAYGRYHA DPNMDPYRYGQPLPGGKPPQQQ---------QPHPQQQPPQQPGPGGSPNRPPQQRYIPG------QPPQ-GPTPTLNSL LQSSNPPPPP-QHRYANTYDPQ--QAAASAAAAAAAQQQQAGGPPPPGHGPPPPQHQPSPYGGQQGGWAPPPRPYSPQLG PSQQYRTP---------------PPTNTSRGQSPYPPAHGQNSGSYPSSPQQQQQQQQQ-QQQQAGQQPGGPVPGGPPPG TGQQ---------------PPQQNTPPTSQYSPYPQRYPTPPGLPAGGSNHRTAYS---THQYPEPN------------- -RP-WPGGSSPSPG-SGHPLPPASPHHVP-------PLQQQ--------------------------------------- ------------------------------------------PPPP----------PHVSAGGPPPSSSPGHAPSPSP-Q PSQASPSPHQELIG----QNSNDSSSGGAHSGMGSGPPGTPN------------PQQVMRPTPSPTGSSGSRSMSPAVAQ N------------HPISRPASNQS--SSGGPMQQPPVGAGGPPPMP------PHPGMPGGPPQQQQSQQQQASN--SASS ASNSPQQT-PPPAPPPNQGMNNMATPPPP-------PQGAAG--------------GGYPMPPHMHGG------YKMGGP GQSPGAQGYPPQQPQQYPPGNYPPRPQYP---PGAYATGPPPPPTSQAGAGGANSMPSGAQAGGYPG-RGMPNHTGQYPP YQWVPPSPQQTVPGGAPGGAMVGNHVQGKGTP---------PPPVVGGPPPPQGSGSPRPLNYLKQHLQHKG--GYGGSP TPPQGPQGYGNGPTGMHPGMPMGPPHHMGPPHGPTNMGPPTSTPPQSQMLQGGQPQGQG--------------------- ---------ASGGPESGGPEHISQDNGISSSGPTGAAGMHAVTSVVTT-----GPDGTSMDEVSQQ-------------- --STLSN---ASAASGEDPQCTTPKSR---KNDPYSQSHLAPPSTSPHPVVMHPG--------------------GGPGE EYDMSSPPNWPRPAGSPQVFN----------------------------------------------HVPVPQEP--FRS TITTTKKSDSLCKLYEMDDNPDRRGWLDKLRAFMEERRTPITACPTISKQPLDLYRLYIYVKERGGFVEV---TKSKTWK DIAGLLGIGAS--SSAAYTLRKHYTKNLLTFECHFDRGDIDPLPIIQQVEAGSKKKTAKAAS-VPSPG--GGHLDAGTTN ST------------GSSNSQDSFPAPPGSAPNAAIDGYPGYPGGSPYPVASGPQPDYATAGQMQRPPSQNNPQTPHPGAA AAVAAGDNISVSNPFEDPIAAGGGPGSGTGPGPGQGPGPGAASGGAGAVGAVGGGPQPHPPPPHSPHTAAQQAAGQHQQQ HPQHQHPGLPGPPPPQQQQGQQGQQPPPSVGGGPPPAPQQHGPGQVPPSPQQHVRPAAGAPYPPGGSGYPTPVSRTPGSP YPSQPGAYGQYGSSDQYNATGPPGQPFGQGPGQYPPQNRNMYPPYGPEGEAPPTGANQYGPYGSRPYSQPPPGGPQPPTQ TVAGGPPAGGAPGAPPSSAYPTGRPSQQDYYQPPPDQSPQPRRHPDFIKDSQPYPGYNARPQIY---------------- -----------GAWQSG-TQQYRPQYPSSPAPQNWGGAPPRGAAPP--PGA---PHGPPIQQPAGVAQWDQHRYPPQQGP PPPPQQQQQPQQQQQQPPYQQVAGPPGQQPPQAPPQWAQMNPGQTAQSGIAPPGSPLRPPSGPGQQNRMPGMPAQQQQSQ QQGGVPQPPPQQASHGGVPSPGLPQVGP--GGMVKPPYAMPPPPSQGVGQQVGQGPPGGMMSQKPPPMPGQAMQQQPLQQ QPPSHQHPHPHQHPQHQHPHQMPPNQTAPGGYGPPGMPGGGAQLVKKELIFPHDSVESTTPVL-YRRKRLMKADVC-PVD PWRIFMAMRSGLLTECTWALDVLNVLLFDDSTVQFFGIS-NLP--GLLTLLLEHFQKNLAEMFDERENE----------- EQSALLAEDADDDADSGTVMCEKLRTSGRQPR----------------------------CVRSISSYNRRRHYEN-MDR SG-----KDGAGNGSDSEDADEG---------------------------IDLGQVRVQPNPEERSLLLSFTPNYTMVTR KGVPVRIQPAENDIFVDERQKAWDIDTNRLYEQLEPVGSDAWTYGFTEPDPLDGIIDVFKSEIVNIPFARYIRSDKK--- ------GRKRTELASSSRK----------------------------------------------------PEIKTEENS TEEQTFNKKRR------------------------LVS-GGSSSSGAHAEGKKSKLTSEEFAQPNAEVKKE--------- ----------------PGTADSDCRPVDMDIEAPQQRLTNG-------------VAPCSSTP------------------ ----------------------------------------AIFDPRTTAKDEARVLQRRRDSSFEDECYTRDEASLHLVS ESQDSLARRCIALSNIFRNLTFVPGNETVLAKSTRFLAVLGRLLLL--------NHEHLRRTPKTRNYDREE-------- ----DTDFSDSCSSLQGEREWWWDYLITIRENMLVAMANIAGHLELSRYDE-LIARPLIDGLLHWAVCPSAHGQDPFPSC GPNSVLSPQRLALEALCKLCVTDANVDLVIATPPFSRLEKLCAVLTRHLCRNEDQVLREFSVNLLHYLAAADSAMARTVA LQSPCISYLVAFIEQAEQTALGVANQHGINY-----------------------------------------LRENPDSM GTSLDMLR------------------------------------------------------------------------ ------------------------------RAAGTLLHLAKHPDNRSLFMQQEQRLLGLVMSHILDQQVALIISRVLYQV SRGTGPIHSVEFRLLQQRQQQQLRPGPAGKQAASAG-----------GSATVKAETASTETSSTEAKPAPAATTAVVNDE NSNSSQQLPPAATFNDVSNSS----------TNSNSCGTASSNQTNNSTTNSSHSSS--AISSQSAITVAAPSAAATGAG SATAAAIASDQQQVSKVAAAAAAAAALSNASAAAAAAAAAAAASVGPPTSSSVSAGAAVAQPAAPPPTNAGTTTAVA--- ----------- >Apis_mellifera_ARID1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MAATQAESQQ NDVKLNESVKCAQKRPQVGGNSAS----VNTKQQLDPEPGDKVSRGAAQLLKYVNR-------GGDTG---FEMSQYR-- -------------------------------EDIGGHTAGEVKSPREAGQAPQESIGKQEPLDTPGHPN----HPGHPFT SNVIRDYPEEYTNKSNEFPSKS--------LTEYPSKQVPEYIGKHG--DFPGKQLDYHG-----------------KHL IHESE-------------------RVHRAEMEEHYAASKIESRLAYVGATPSSFPGQPRFLSGQ---------SISQATG PTP--------------------TLNQLLQASTPVHRFHGNYPGMGPEPYQQPWPIQRPPVVPPVYPQPGQRPPQTGSPR LHAG---------------PGGPSSPTPMPYQQYTQRYSSPARPHAPYSHHQLNSY---TTQSSHPS------------- --SLYTEQRGWNQGGPPNPPPPPANQTNPSSQSPQRALSQS--------------------------------------- ------------------------------------------PAPP--------------PSASPQPQSTGQSQSFHNLQ QRSTTPNTQGIDSGELSGQNSNDSSN-------GPACPGTPN-------------SQGMRPTPSPTGSTGSRSMSPAVGQ QN----------VQMPPRPSSSQSDGSGPARMSHSPMTT---------------QGAYQQPLGPSPHMHSYKMN------ -NTGPGVVQPGPGSASLGGMNPMG--------------------------------GGMGYAASGTAA---------GQP GGYHTQGTYPPPRPHVQFPQGYPSP-----------ANSQPPPNNQYQASNRPNNLVQYP------------PYTHKMGF NSVPPGMPPSPGPPQVYGGSSTTGMVPP-GTP---------GVAVIGNMGPPASSMGPPPP----------SPNHISSQP PPTSSAVPHLHTPAATPP--LNHEGSPMPPPSTTPNSHPTSTPTPASHNS------------------------------ ---------ADLTTETSNDSGITTTASGTSGINVTSTSSGTVTSVITT-----GPDGTSLDEGSQQ-------------- --STLSN---ASAASGEDPAFTPKVRK--EMIGGYHSHPTTPQSTVPSPGAASIN---------------------SIHE EYPDMNSPGWPRTPASP--------------------------------------------------------------- ------KPDSLAKLYEMDDSMERRTWLDKLVNFMEERRTPITSCPTISKNPLDLFRLYLYVKERGGFMEV---TKNKTWK DIAGLLGIGAS--SSAAYTLRKHYTKHLLAYECHFDRGGVDPQPIINQVEAGSKKKPSKATASVPSPG------------ ---------------SSNSQDSFPAAGSSN--ASMDGYGSYQSSYTGGTPGGPSSEYTPPPPRPPSQ----------SSA PSPHQGG------------LNQGGQNSTNPFDDGVGR-LFRKSN-----------ATPHPG----PLRASGIQQGSYQNT GSYQNYPQDQYIRPQANTLSQQGEFN-------QPYSPRSHYSPYVP--DVDRGYPGGNMPPNNAGG------------- ----QDIYNRYSSSQQP-ANYSAGTPPNARSNSYPSAP-QAHPATVPQQTATS-----------QPSSPSQPSAASSYSC PQDYYRQEQGGYGAPGGTQIYSSGANANKNMPPPPPGPNPPRRHPDFAKDQQ-YPQYNQQ-------------------- ----------------------RPAYP-----------------------------GWPNTTNQYNSTSGNNRVQYPSQQ PQSQTQQQQQQS--------------QQQTPQSASS--------TPSSGLAN-----NQQWGSQQPNRTTPQPTLN---- --AIAHAPPPWDHRYSNQPSP-------------------LYPAPGNHQNQLG---------------INPMINQQP--- -------------------------------------------TSKREMTFPPDSVEAITPLL-YKRRKLTRADVA-PIE AWRIMMALRSGLLAESCWALDVLNILLFDDSSVSYFGLA-HLP--GLLDVLLEHFSRSLSDMFESPVNEDDRN------- -------------------------------------------------------------------------------- -------WNQSADGPE----------------------------------VDLGAVTRPIDPEDRTKLLSSS-NYTLLSR RGRPVKIIPRDDDLFVLDTRRSWD-------HQDCESETEPWQVDNN---TTKYIVTCFQSEIGTVPFARLLRDEKPPLL QKEVECTDLKDETKADSGTLES------------------------------------------LEFSQKITESGEKPKE TNEKKQLDKKKK----------------------TKTL-SDVLSRIKKEPVEMNDLTRELFEKKNDGFKKECDTEAKVNN N---------------MGEHFSDMQKSEEELILAQNGLNDTTNNIEMEKNEIKIENEEQESVMKND-------------- ----------------------------------------NKEGPRLKIRDPAGTLKRRRISDYEDESYSRDEASLYLVT ETQDNLARRCVCLSTILRNLTFIPGNEAEFAKNVTFLSLLGKLLLL--------HHEHPVRTQKTRNYDREE-------- ----DADFADSCSSLQGESEWWWDFLHHIRENVLVMAANIAGHMDLSQHPE-EISRPVLDGLLHWAVCPAAHGQDPFPTV GPNSSLSPQRLALEALCKLCVTECNVDLVVATPPYSRLQRLCSVLTRLLCRSEEQVLREFGVNLLHFLSAADSGVARTIA LQTPCVALLVAFIEQAESSALGVANQHGLAA-----------------------------------------LRDNPESM GTSLDMLR------------------------------------------------------------------------ ------------------------------RAAGTLLNLARHPDNRTLLLQHESRLLALVMSQILDQQVAAIVARVLFQC SRGT---------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Caenorhabditis_elegans_ARID1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MP-------------------------GDDNAVGTETNEDKPTTSNAVTAEN ----------------PSRGDE----------SQQQQQQPQQQQKRG---------EDADKYAASVAEVAHGG-----GG PKKDDQVPPAPDASMPTPQQQQQQ--------------------------------------PNLPPPQQPYEHP----A QQHPPQHHSVPP-------NSFAPPPGQHHPQHPGMPPMEWRPPGAEYQMPPGYPAGYPP-----------------YGM PPRHHPGYPHPAYGYPPPG-----APYGYPPQMMRPPMMAPGDMVRMPPGPTPTEWAAQQQAQAAS-----------RSV PPKEGPNGNPATPSSSSQPIPSPSASSIAEES---LDDKPSG-------------------------------------- -------------------------TKMPAQPPPQQHPPPPQPQQIMSPMPPQAPPSQQATPSS---------------- -SAASVAAPDTPKVSGKVLSKAELFEKLVG-------------------------------------------------- -------------------------------------------------------------------------------- ---------PITLHNPMKVMAERRGFFERLIEFCEHNGEPLTMVPQVSKQSIDLHRLYIGVRAKGGFQQVT---KDKYWK NLCTEANPDLAESSAAGYQLRKHYQRHLLMLECRETGRNPEDEVAFADKMKRQRKREPAGGNAAAAAA------------ -------------------VAAAQQGDQKSQHGAPGGSGAPPPGPPGAYPGNGAPGGPPGG------------------- ----------------------PPQFPGHPGMDPNYHYYQQHGMMP--------PHPGHPGYPPQHMNAFSPGQYPGHQR PPGGPGGPPPGPQAMRAPMPQHMQEMDEHQRQWYAHQQAAAAHHHAQQQAAAQAQAAQAQQASTPAP------------- ----STTPAPQAASSSQAAPTSGANTQPATPSASNQPPTPASASASTTLHVEPASVAG--------------GSQAGSRA PSAGPGPSATPDSSTIPSASAAADAQTTTSSETSTPGEPTSSTPSDTPAPSTSVPPPTSVQ------------------- -----------------PPQPQQPPQGPPGP----PGPQQHPGPYPGYPGYGPPGAMRPPAGFAPPPGAPYGYPPGAPPP AGFHPSHPQHPQHAQYLAWQQQRYHQQQQHQQQQQQGAPGGPRPPYP----------YPGGPVPPGPPQNRMPPPPPAQG APSPSGAAGSNGKQPRYGTPAPPSRASAPTPQPLSSTMPVVAPSTSTQPTPTTGSYLANTLATPGPAHAPSSSMSHAHHV IS-------------------------------------------QQQHQYPPGCIEATATSQNQVKRRKVYARELINAT PRRLIMSLRSGLDAEAIWAINALNVLLYDDTNPHPTLQQ--MP--GLVNVIVEHLYATLS--IMYPAEFQLTEPGKPIIM DES------KETVEKMMKAEKDG--------------------------------------------------------- -------------------------------------------------------------GIKSIIEKMPVVPRKGSDK TATFTMMSRNGLQVHFRDESIPTALRKRFSRESGEKNSDAMVDHSISSAYVEDRNSVGLGGGLAERIATRLRDKLLHEKT RP------------------------------------------------------------------------------ -----------------------------------------RPVFSKYLDDLETESTETIDTVEVKKEIED--------- ------------------EVAEEKKDVLLMRGARPDELS----------------------------------------- ------------------------------------------------------------DCKHEVELAWPRPTALSPKS QAMEELAHRALALSNILRGFSFVAGSDVLMARNEALLFIIGRLLKLNVK-----EHKISSKRPGIVMSAEELKTAPKQLS ADEKRAKEKSVLDEVDATTAQMVETANQLRDDAFVMLTHMSVSLNLVDLPD-AIAYPIYDGLLRWSVSRVPEATDS---- SIPCPVSPRDYSLEIMCKMVVIERNVDMFLSTGSWSRVEQFVHILTRLLTMNEETHYREFAIVILNALCIASEAVCYICA METSAIAHLILFIDSADQNMHQVMQAHGMAA-----------------------------------------LRDNPELM GTSVGMLR------------------------------------------------------------------------ ------------------------------RAASMLRLLVKVPKAYKIYMKHQTRLLQFTMSQLMDSRVAGMIADTLYEI QEFVKEFGEDVPEPLKITYSEGYQPSQTDDKESTSTNSDAAAPPQKSTSSSPKPVEESAATTSVNVHGNGTLECETSSRP LSSEAAAAVITPYENHHKNEEEEDLKKEIDEGESCDGYDTEAIRLSQKRSAAALIDEQSRSPPPAKRAHLSNGFDKSKSS VSTNGTLGDASQNDGALTTAVA---------------------------------------------------------- ----------- >Homo_sapiens_ARID1B -MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAP PHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQ--QHPISNNNSLGGAGGGAPQPGPDMEQP QHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVP-EFNNYYGS AAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGG GGGSGGGGGGGGAGA-----GGA-------GAG-AVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPG GGGAA-----------------SLSKAAA-GSAAG-GFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYP-EYSSP SAPPPPPSQPQS-QAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHP---AMSPGTPGPTMGRSQGSPMD PMVMKRPQLYGMG---------SNPHSQ----------PQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQD SGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQA--------------------------------- -------------------------------------------------------------------------------- ----------------------------------------QYLPS-------------------------QSQQRYQPQQ D--MSQEGYG--TRSQPPLAPGKPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASG --------------STSSQGDQ---SNPAQ-SPFSPHASPHLSSIPG---------GPSPSPVGSPVGSNQSR-----SG PISPASIPGSQMPPQPPGSQSESS------------------------------------SHPALSQSPMPQERGFMAGT QRNPQMAQYGPQ----QTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQ-----------------GNYSR PPAYSGVP-SASYSGPGPG-----MGISANNQMHGQGPSQPCGAVPLGR-MPSAGMQNRPFPGNMS-----SMTPSSPGM SQQGGPGMGPP-MPTVNRKAQEAAAAVMQAA----ANSAQSR-------------------------------------- --------------QGSFPGMN--QSGLMASSSPYSQPMNNSSSLMNTQA-PPYSMAPAMVNSS---------------- -AASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSK----------------------------------------- --------------KSSSST------------------------------------------------------------ -----TTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQYLFAFECKIERGEEPPPEVFST---GDTKKQPKLQPPSPANS------------ -----------------GSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGG-------------------- --------------------RSSTISVHDPFSDVSDSSFPKRNS-----------MTPNAPYQQGMSMPDVMGRMP-YEP NKDPFGGMRKVP-GSSEPFMTQGQMPNSSMQD----------MYNQSPSGAMSNLGMGQRQQFPYG-------------- ------ASYDRR------------------------------------------------------------HEPYGQQY PGQGPPSGQPPYGGHQPGLYP--QQP-NYKRHMDGMYGPPAKRHEG----DMYNMQYSSQQ------------------- -------------------QEMYNQYGGSYS-----GPDRRP-----IQGQYPYPYSRERMQG-PGQIQTHGIPPQMMGG PLQSS-SSEGPQQNMWAARNDMPYP-YQNRQGPGGPT-QAPPYPGMN-RTDDMMVPDQRINHESQWPSHVSQRQP--YMS SSASMQPIT-RPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKS-PFLP---SMKMQKVMPTVPTSQVTGPPPQP PP------------------------------------------IRREITFPPGSVEASQPVL-KQRRKITSKDI-VTPE AWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLS-QLS--GFLELLVEYFRKCLIDIFGILMEYEVGDPSQK-AL DHNAARKDDSQSLADDSGKEEED-AECID--------------------------------------------------- ----------DDEEDEEDEE--------------------------------EDSEKTESDEKSSIALTAPDAAADPKEK PKQASKFDKLPIKIVKKN--NLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGR KK---------EQEG----------------------------------------------------------------- -----------------------------------------KGDSEEQQEKSIIATIDDVLSARPGALPED---ANP--- ------------------GPQTESSKFPFGIQQAKSHRN----------------------------------------- ------------------------------------------------------------IKLLEDEPRSRDETPLCTIA HWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILL--------HHEHPERKRAPQTYEKE--------- -------EDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTE-SICLPILDGLLHWMVCPSAEAQDPFPTV GPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIA VQKGSIGNLISFLEDGVTMAQYQQSQHNLMH-----------------------------------------MQPP-PLE PPSVDMMC------------------------------------------------------------------------ ------------------------------RAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQI GQL----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------- >Pongo_abelii_ARID1B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------GSPMD PMVMKRPQLYGMG---------SNPHSQ----------PQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMGGMQYPQQQ- ------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQA--------------------------------- -------------------------------------------------------------------------------- ----------------------------------------QYLPS-------------------------QSQQRYQPQQ D--MSQEGYG--TRTQPPLAPGKPNHEDLNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASG --------------STSSQGDQ---SNPAQ-SPFSPHASPHLSSIPG---------GPSPSPVGSPVGSNQSR-----SG PISPASIPGSQMPPQPPGSQSESS------------------------------------SHPALSQSPMPQERGFMAGT QRNPQMAQYGPQ----QTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQ-----------------GNYSR PPAYSGVP-SASYSGPGPG-----MGISANNQMHGQGPSQPCGAVPLGR-MPSAGMQNRPFPGNMS-----SMTPSSPGM SQQGGPGMGPP-MPTVNRKAQEAAAAVMQAA----ANSAQSR-------------------------------------- --------------QGSFPGMN--QSGLMASSSPYSQPMNNSSSLMNTQA-PPYSMAPAMVNSS---------------- -AASMGLADMMSPGESKLPLPLKADGKE-GTPQPESKSKDSYSSQGISQPPTPGN-LPVPSPMSPSSASISSFHGDESDS ISSPGWP-KTPSSPKSSSST------------------------------------------------------------ -----TTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVN---KNKKWR ELATNLNVGTS--SSAASSLKKQYIQYLFAFECK