>Human_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MGSS-ATEIEELENT------------------------------------TFKYLT----------- -------------------------------------------------------------------------------- ------------------------GEQTEKMWQRLKGILRCLVKQLE-RGDVNVVDLKKNIEYAASVLEAVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPK--FRSIVHAVQAG IFVERMYRKTYHMVGLAYPAAVIVTLKD------VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIT FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA ILYNDRSVLENHHVSAAYRLMQE-EEMNILINLSKDDW--RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-IDRA KTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF SLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIV-------------GLHIADALRRSNTKGSMSDGSYSPDYSLAAVD LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------ESDLHKNSEDLVNA--EEKHDETHS -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Mouse_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MGST-DTDIEELENA------------------------------------TYKYLI----------- -------------------------------------------------------------------------------- ------------------------GEQTEKMWQRLKGILRCLVKQLE-KGDVNVVDLKKNIEYAASVLEAVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMMKKKPEEKPK--FRSIVHAVQAG IFVERMYRKNYHMVGLTYPAAVIVTLKE------VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIA FAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA ILYNDRSVLENHHVSAAYRLMQE-EEMNILVNLSKDDW--RDLRNLVIEMVLATDMSGHFQQIKNIRNSLQQPEG-IDRA KTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF SLLTDSTEKIVIPLIEEASKSQSSNYGASSSSTMI-------------GFHVADSLRRSNTKGSVCDGSYAPDYSLSAVD LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------ELDLHKNSEELGNT--EEKHADTRP -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Rat_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MGST-DTDIEELENA------------------------------------TYKYLI----------- -------------------------------------------------------------------------------- ------------------------GEQTEKMWQRLKGILRCLVKQLE-KGDVNVVDLKKNIEYAASVLEAVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPK--FRSIVHAVQAG IFVERMYRKNYHMVGLTYPAAVIVTLKE------VDKWSFDVFALNEASGEHSLKFMIYELFTSNDLINRFKIPVSCLIA FAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAVHDYEHTGTTNNFHIQTRSD---VA ILYNDRSVLENHHVSAAYRLMQE-EEMNILVNLSKDDW--RDLRNLVIETVLATDMSGHFQQIKNIRSSLQQPEG-IDRA KTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF SLLTDSTEKIVIPLIEEASKPESSNYGASSSSTMI-------------GFHVADALRRSNTKGCMSDGTYAPDYSLSAVD LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------ELDLHKNSEDL-----EEKHADTHP -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Cow_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MD----------DHV------------------------------------TIR-------------- -------------------------------------------------------------------------------- ----------------------------RKHLQRPIFRLRCLVKQLE-KGDVNVIDLKKNIEYAASVLEAVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTDDELSDIQSDSVPSEVRDWLASTFTRKMGMMKKKSEEKPR--FRSIVHVVQAG IFVERMYRKSYHMVGLAYPEAVIVTLKD------VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIA FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA ILYNDRSVLENHHVSAAYRLMQE-EEMNVLINLSKDDW--RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-LDKA KTMSLILHAADISHPAKSWKLHHRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF SLLTDSTEKIIIPLIEEDSKTKTPSYGAS---------------------------RRSNMKGTTNDGTYSPDYSLASVD LKSFKNSLVDIIQQNKERWKELAAQG-----------------------------EPDPHKNS-DLVNA--EEKHAETHS -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Dog_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MD----------DHV------------------------------------TIR-------------- -------------------------------------------------------------------------------- ----------------------------KKHLQRPIFRLRCLVKQLE-RGDVNVVDLKKNIEYAASVLEAVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMMKKKSEEKPK--FRSIVHAVQAG IFVERMYRKSYHMVGLVYPEAVIVTLKD------VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIS FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA LLYNDRSVLENHHVSAAYRLMQE-EEMNVLINLSKDDW--RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-IDKA KTMSLILHAADISHPAKSWQLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF SLLTDSTEKIIIPLIEEASKTDTSSYGAS---------------------------RRSNMKGTMNDGTYSPDYSLASVD LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------EPDLHKNSEDLVNA--EEKHVDTHS -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Horse_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MGST-AADTEELENT------------------------------------TFKYLI----------- -------------------------------------------------------------------------------- ------------------------GEQTEKMWQRLKGILRCLVKQLE-KGDVNIVDLKKNIEYAASVLEAVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMKKKKSEEKPK--FRSIVHAVQAG IFVERMYRKSYHVVGLAYPEAVIVTLKD------VDKWSFDVFALNEASGEHSLKFIIYELFTRYDLINRFKIPVSCLIA FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA ILYNDRSVLENHHVSAAYRLMQE-EEMNVLINLSKDDW--RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-IDRA KTMSLILHAADISHPAKSWQLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF SLLTDSTEKIIIPLIEEDSKTENPSYGASRFGTFM-------------G?HVADLFRRSNIKGTMNDGTYSPDYSLACVD LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------ESDLHKNSEDLANA--EEKHADIHS -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Platypus_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MGST-ATELEEYGST------------------------------------SLKYLI----------- -------------------------------------------------------------------------------- ------------------------GEQTEKMWQRLKGILRCLVKQLE-KGDVNVVDLKKNIEYAASVLEAVYIDETRK-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDSVPLEVRDWLASTFTRKMGMAKKKTEEKPK--FRSIVHAVQAG IFVERMYRRTSNMAGLAYPAAVIVTLKD------VDKWSFNVFALNDASGEHSLKFMMYELFTRYDLISRFKIPVSCLIS FAEALEVGYSKFKNPYHNLIHAADVTQTVHYILLHTGLMHWLSELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA ILYNDRSVLENHHVSAAYRLMQE-EDMNILTNLSKDDW--RELRGLVVEMVLSTDMSGHFHQIKTMRNTLQQPEG-VDKG KAMSLILHAADISHPAKSWDLHHKWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF SLLTDSTERIVVPLIEESCRSESSCLPCSPSPTSQNSDG---------GLTATDTQKKPSGKLTSNEGPSSSNYSLASVD LKSFKNNLVDIIQQNKERWKELALQERVL------------------------RSDRKLKKKHRPAPGAKLEDKGSSSDS KDIKESSGGQSLMGASAPDPAANPSGSRPQLWLKSGPIPRPDGDDGDIEIERHFLSSSQVEEVFM--------------- -------------------------------------------------------------------------------- --------------- >Zebrafinch_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------MTQDQ----------- -------------------------------------------------------------------------------- ------------------------QDTCALLEQQLATRLRCLVKQLE-KGDINVVDLKKNIEYAASVLEAVYIDETRK-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDSVPLEVRDWLASTFTREMGIVKRRPEEKPK--FRSIVHAVQAG IFVERMYRKTSSMVGLAYPAEVIVTFKD------VDKWSFDVFALNEASGEHSLKFMMYELLTRYDLLSRFKIPVPNLIS FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMIHTGIMHWLTELEILAMIFAAAVHDYEHTGTTNNFHIQTRSD---VA ILYNDRSVLENHHVSAAYRLMQE-EEMNILANLNKDDW--RELRSLVIEMVLSTDMSGHFQQIKTMRHTLQQAQG-VDKA KAMSLILHAADISHPAKSWELHYRWTMALMEEFFRQGDKEAALGLQFSPLCDRKSTLVAQSQIG------FIDFIVEPTF SLLTDSMEKIVMPLIEEATKSESPAFGTPSQNSLG-------------AVSNAEAQRRPGFKSTG-DGGTHTENSLATVD LRGFKDNLMKIIQANKERWKELAAEGEPKHCKS-----------------------EDIVKATEQ---------TEALVQ N------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Chicken_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------MTQDL----------- -------------------------------------------------------------------------------- ------------------------QDTCALLEQQLGTRLRCLVKQLE-KGDINVVDLKKNIEYAASVLEAVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDSVPLEVRDWLASTFTREMGIVKRRPEEKPK--FRSIVHAVQAG IFVERMYRRTSSMVGLAYPAEVIVTFKD------VDKWSFDVFALNEASGEHSLKFMMYELFTRYDLLNRFKIPVPNLIT FAETLEVGYSKYKNPYHNLIHAADVTQTVHYILIHTGIMHWLTELEILAMIFAAAIHDYEHTGTTNNFHIQTRSD---VA ILYNDRSVLENHHVSAAYRLMQE-EEMNILANLTKDDW--RELRSLVIEMVLSTDMSGHFQQIKTMRHTLQQAEG-VDKA KAMSLILHAADISHPAKSWELHYRWTMALMEEFFRQGDKEAALGLQFSPLCDRKSTLVAQSQIG------FIDFIVEPTF SLLTDSMEKIVMPLIEEASKSESPAFGTPGQNNLG-------------AVSNVDAQRRHNFRSTASDGAAHTENSLATVD LRSFRDNLMQIIQANKERWKELAVEVRYKLLMVSVTVGSGGKGISLEIPVYLMPSEEELVKNVDEQEKDQSRNSTDAQLQ EETRSRQNESSQGSGGTACPPRPIVLQVVTSNTSLSDESNSEKCTNSDPNQKDLTDAQQETQNTDPLNDTSVKLLYTAVC -------------------------------------------------------------------------------- --------------- >Anolelizard_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MGSTGTERNEGMDSA------------------------------------LLKYPI----------- -------------------------------------------------------------------------------- ------------------------RGHTEKMWQRLKGILRCLVKQLE-KGDVNIIDLKKNIEYAASVLEAVYIDETRK-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTDDELSDMRTDSVPMEVRDWLASTFTRKMGMTKRRPEEKPK--FRSIVHAVQAG IFVERMYRRTSSMVGLAYPSEVITTFKD------VDKWSFDVFALNEASGGHSLKFMMYELLIRYDLVSRFKIPVPSLIS FAETLENGYSKHRNPYHNLIHAADVTHTVHCILLLTGIMHWLTELEILAMIFAAAIHDYEHTGTTNNFHIQTRSD---VA MLYNDRSVLENHHVSAAYKIMQE-DEMNILLNLSKDEW--RELRTLVIEMVLSTDMSGHFQQIKTIRHTLQETEG-IDKA KAMSLILHAADISHPSKTWNLHFRWTKALMEEFFQQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVKPTF ALLTDSMEKIVLPLIVEASKSETSTITSRKTVNMG-------------GLHFKQKYHHLEVQKKL-TIKTSTCSGLSAVD LNRFKEDLFQIVQENKDRWKDLAEKG------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Frog_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MEST-AFESEDPEYP------------------------------------SSNFET----------- -------------------------------------------------------------------------------- ------------------------RESNDKMVQRLQGILRCLVKQLE-KGDINVTDLKNNIEYAASVLEAVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIHTDSVPLEVRDWLASTFTRKMGMRKRRPEEKPK--FRSIVHAVQAG IFVERMYRRSSNIAGLTYPSSVIASMKD------VDRWAFNVFTLNEASGEHALKFMVYELFTRYDLTNRFKIPVSNLVS FVEALEVGYSKYKNPYHNLVHAADVTQTVHYIILHTGIMHWLTELEILAMIFAAAIHDFEHTGTTNNFHIQTRSD---VA ILYNDRSVLENHHVSAAYRIMQD-DEMNIFINLSKDDW--RDLRTLVIEMVLSTDMSGHFQQLKTMRSTLQQPEG-IDKA KAMSLILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEAALGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF TLLTDSTEKIVFPLIEEAAKSDNSVFDKSSQNNSE-------------VVRGTDTPRKPSVRTSQMDGSSPSEYSLATVD LHHFKKNLVEIIQQNKERWKELAAQE------------------------------RNLKSTHKSEGGT------GGT-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Zebrafish_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MDED----------- -------------------------------------------------------------------------------- ------------------------VTIKRKLLHRPIFRLRCLVKQLD-KGEVNVVDLRKNIEYAASVLEAVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPR--FRSIVHAVQAG IFVERMYRRTSNMAGLTYPPSVITALKD------VDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVS FVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSE---VA ILYNDRSVLENHHVSAAYRLMQE-DEMNILVNLSKDDW--RELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEG-IDKA KALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIG------FIDFIVEPTF SVLVDTTEKIISPLIEEAVKS--GGVRRSSLTGRGS-------------AAVVESVQRHSDRGSNDECGGSTDYSLCGID QKHVRHLLSEIIQNNKERWKELSVQGLTQI-------------------------SLSLHTASQKTGHSQLANKQHERMS DLQEEPMRSTQLTLSQENHDSESKSLNELNNTDSTHSSQDSLDQSSQSPTEGAGDASPEEHSSETLPWNGKSA------- -------------------------------------------------------------------------------- --------------- >Medaka_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------LYSS--HQLIIIICT------------------------------------QVFKYI----------- -------------------------------------------------------------------------------- ------------------------HLQKRRKIMTGILMLKAALEQMD-RGVVDLQELRRNLELAAAMLDAVYTDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDLQAESVPSEVRDWLACTFSRRTGLSKRRPEEKPR--FRSIVHAVQAG IFVERMYRRTSNMAGLTYPPTALNALKE------VDQWSFDVFTFHDATGEHALKFIVYDLLTRYDLINRFRIPVQALVQ FVEALESGYSKHRNPYHNLIHAADVTQTAHFLMLHTGLMHWLSELEILAMVFAAAIHDFEHTGTTNNFHIHTRSE---VA ILYNDRSVLENHHVSAAYKLMAE-EDMNILVNLNKDDW--RELRSLVIEMVMSTDMSCHFQQIKTMRNSLTQTDS-IDKV KVLSLMLHAADISHPAKAWPLHYHWTHSLMEEFFRQGDKEVELGLPFSPLCDRKATMIAQSQIG------FIDFIVEPTF SVLIDTTDKVIGPLIEEDRKARETGNRRPSLTGSG--------------SVTVESVQRHSSGLHGNSDDGPTDFSLTAID LPALRLHLSSVIVSNKERWKELSVHG-----------------------------KYTVHKSS---------------LS LLQ-------QAQISKATHH------------------------------------------------------------ -------------------------------------------------------------------------------- --------------- >Stickleback_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---TKEIEEFE----------------------------------STSLKYLQ----------- --------------PEQIEKIWLR-------------------------------------------------------- -------------------------LRGLRKYKKTSQRLRCLVKQLE-RGEASLTDLKKNLEYAALVLESVYIEETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LVDTEDELSDIQSESVPSEVRDWLASTFTRQMGLMLRRNEEKPR--FRSIVHAVQAG IFVERMYRRTSNMVGLSYPPSVISVLKH------VDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISAVVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSD---TA ILYNDRSVLE-HHVSAAYRLLQEDDEMNILYNLSKDDW--RELRALVVEMVLATDMSCHFQQVKTMKNFLQQPEG-IDKP KALSLLLHTADISHPAKSWNLHHRWTTSLLEEFFRQGDKESELGLPFSPLCDRKSTMVAQSQIG------FIDFIVVPTF TVLTDMMESIVKPLIDEASHAGFSGFRRS--SLNS---------------ISSEEAKRHSVKS--SDSSSSGHSSLLTVD LKNFKALWNEEVYQNRERWKAQAAKEA----------------------------EERAKREAEEQAQQEEAME------ ---PQEAHTEPE-------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Tetraodon_PDE1A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------LRCLVKQLE-RGEASLNDLKKNLEYAASVLESVYIEETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LVDTEDELSDIQSESVPSEVRDWLASTFTRQMGLMLRRNEEKPR--FRSIVHAVQAG IFVERMYRRTSNMVGLSYPPSVISVLKN------VDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSD---TA ILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDW--RELRALVVEMVLATDMSCHFQQVKAMKNFLQQPEG-IDKP KALSLLLHTADISHPAKNWDLHHHWTTSLLEEFFRQGDKEADLGLPFSPLCDRKSTMVAQSQIG------FIDFIVVPTF TVLTDMMERIVTPLIDEASHSGFSGFRRSRHSLNS---------------ISSEEAKRQSVKSMGSDSSSSGPSSLLTVD IKNFKHVD-EEVYQNRERWKAQACKGE----------------------------REQEQRCGCYLHR------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Human_PDE1B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MELSPRSPPEMLEESDCPS--------------------------------PLELKS----------- -------------------------------------------------------------------------------- -------------------------APSKKMWIKLRSLLRYMVKQLE-NGEINIEELKKNLEYTASLLEAVYIDETRQ-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------ILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPK--FRSIVHAVQAG IFVERMFRRTYTSVGPTYSTAVLNCLKN------LDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMS FLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA IVYNDRSVLENHHISSVFRLMQD-DEMNIFINLTKDEF--VELRALVIEMVLATDMSCHFQQVKTMKTALQQLER-IDKP KALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF SVLTDVAEKSVQPLADEDSKSK----------------------------------NQPSFQWRQPSLD--VEVGDPNPD VVSFRSTWVKRIQENKQKWKERAASGITN------------------------QMSIDELSPCEEEAPPSPAEDEHNQNG NLD----------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Mouse_PDE1B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MELSPRSPPEML-ESDCPS--------------------------------PLELKS----------- -------------------------------------------------------------------------------- -------------------------APSKKMWIKLRSLLRYMVKQLE-NGEVNIEELKKNLEYTASLLEAVYIDETRQ-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------ILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPK--FRSIVHAVQAG IFVERMFRRTYTSVGPTYSTAVHNCLKN------LDLWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMS FLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA ILYNDRSVLENHHISSVFRMMQD-DEMNIFINLTKDEF--AELRALVIEMVLATDMSCHFQQVKTMKTALQQLER-IDKS KALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF SVLTDVAEKSVQPLADDDSKPK----------------------------------SQPSFQWRQPSLD--VDVGDPNPD VVSFRATWTKYIQENKQKWKERAASGITN------------------------QMSIDELSPCEEEAPSSPAEDEHNQNG NLD----------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Rat_PDE1B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MELSPRSPPEML-ESDCPS--------------------------------PLELKS----------- -------------------------------------------------------------------------------- -------------------------APSKKMWIKLRSLLRYMVKQLE-NGEVNIEELKKNLEYTASLLEAVYIDETRQ-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------ILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPK--FRSIVHAVQAG IFVERMFRRTYTAVGPTYSTAVHNCLKN------LDVWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMS FLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA ILYNDRSVLENHHISSVFRMMQD-DEMNIFINLTKDEF--VELRALVIEMVLATDMSCHFQQVKTMKTALQQLER-IDKS KALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF SVLTDVAEKSVQPLTDDDSKSK----------------------------------SQPSFQWRQPSLD--VDVGDPNPD VVSFRSTWTKYIQENKQKWKERAASGITN------------------------QMSIDELSPCEEEAPSSPAEDEHNQNG NLD----------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Cow_PDE1B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MELSPRSPPEML-ESDCPS--------------------------------PLELKS----------- -------------------------------------------------------------------------------- -------------------------APSKKMWIKLRSLLRYMVKQLE-NGEVNIEELKKNLEYTASLLEAVYIDETRQ-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------ILDTEDELQELRSDAVPSEVRDWLASTFTQQTRAKGP-SEEKPK--FRSIVHAVQAG IFVERMFRRTYTSVGPTYSTAVLNCLKN------VDLWCFDVFSLNRAADDHALRTIVFELLTRHNLISRFKIPTVFLMT FLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA ILYNDRSVLENHHISSVFRMMQD-DEMNIFINLTKDEF--VELRALVIEMVLATDMSCHFQQVKSMKTALQQLER-IDKS KALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF SVLTDVAEKSVQPTGDDDSKSK----------------------------------NQPSFQWRQPSLD--VEVGDPNPD VVSFRSTWTKYIQENKQKWKERAASGITN------------------------QMSIDELSPCEEEAPASPAEDEHNQNG NLD----------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Horse_PDE1B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MELSPRSPPEML-ESDCPS--------------------------------PLELKS----------- -------------------------------------------------------------------------------- -------------------------APSKKMWIKLRSLLRYMVKQLE-SGEVNIEELKKNLEYTASLLEAVYIDETRQ-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------ILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPK--FRSIVHAVQAG IFVERMFRRTYTSVGPTYSAAVLNCLKN------LDLWCFDVFSLNRAADDHALRTIVFELLTRHNLISRFKIPTVFLMT FLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEILAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA ILYNDRSVLENHHISSVFRMMQD-DEMNIFINLTKDEF--VELRALVIEMVLATDMSCHFQQVKSMKTALQQLER-IDKS KALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF SVLTDVAEKSVQPQADEDSKSK----------------------------------NQPSFQWRQPSLD--VEVGDPNPD VVSFRSTWTKYIQENKQKWKERAASGITN------------------------QMSIDELCPCEEEAPSSPAEDEHNQNG NLD----------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Frog_PDE1B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------ME-SPSVDKDLL--EGCTS--------------------------------PFELKS----------- -------------------------------------------------------------------------------- -------------------------APSKKMWVKLRSLLKYMVKQLE-NGEVNIVELKKNLEYTASLLEAVYIDETRQ-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------ILDTDDELPEMRSDSVPSEVRDWLASTFTQQTRSTGRRSEEKPR--FRSIVHAVQAG IFVERMFRRSYTAVGPNYSAAVVNSLKH------LDLWDFDVFVLNRVSEDHALKTIVFELLSRHNLNSRFKIPVAFLMS FLDSLESGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLNEIEILAIIFAAAIHDFEHTGTTNSFHIQTKSD---CA ILYNDRSVLENHHVSAVYRIMQD-DEMNIFVNLTKDEF--TELRSLVIEMVLATDMSCHFQQVKTMKTSLQQLET-IDKS KALSLLLHAADISHPTKQWKVHARWTKALMEEFFRQGDKEAEMGLPFSPLCDRKSTLVAQSQIG------FIEFIVDPTF SVLTDVAEKTVLPLVEERSKSKSTA-----------------------------SVNQSSSQWRQPSIDDHSEMGDINAD IKSFRTTWTKYIQENKQKWKERAASGITN------------------------QTSVDELSPCEEQHSTE-------ENG NLD----------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Fugu_PDE1B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MAELLR----------- -------------------------------------------------------------------------------- -------------------------IRKKRLQIPI-SRLRSILKQLE-EKNVDFEEIKKNLDFTASLLEAVYLDGTRQ-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------CLETEDDLQQLQSDGVPAEVTDWLASTFTRRVRQPARRSDEKPK--FRSIVHAVQAG IFVERMFKRAYTAALPDQPAAVVNCLRD------VDRWSFDVFALNSASSDRALQTVFFELIARYGLNGRFKIPISCLTE FLSAVERGYCKHNNPYHSHVHAADVTQTLHCLLLRSGLVHWLTELEVMASLFAAAIHDYEHTGTTNNFHIHTKSE---FA LIYNDRSVQESHHLSAAFRLLQN-EQMNIFVNLTREEW--MELRSLVIEMVLSTDMSSHLSQVKAIKACLQQQER-IDKP KALSLLLHTADISHPSKPWPLHSRWTKALMEEFFRQGDREAELGLPFSPLCDRNSTLVAESQIG------FIDFIVYPTF SLLTDMAEKIVIPLVEENPGPPD-------------------------------PCNRHSNLWRESSRGLQWSLAHITAE LVSFRSTWTRHTEDNKFKWKESGCNG------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Tetraodon_PDE1B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MAEMLR----------- -------------------------------------------------------------------------------- -------------------------IRKKRLQIPI-SRLRSILKQLE-EKNVDYEEIKKNLDFTASLLETIYFDGTRQ-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------CLETEDDLQQLQSDGVPAEVTDWLASTFTRRVRRPVRRSDEKPK--FRSIVHAVQAG IFVERMFKRAYTAALPDQPTAVVNCLRD------VDRWSFDVFALNSASSDRALQIVFFELIARYGLNGRFKIPISCLTE FLSAVERGYCKYNNPYHSHVHAADVTQTLHCLLLRSGLVHWLTELEVMASLFAAAIHDYEHTGTTNNFHIHTMSE---FA LIYNDRSVQESHHLSAAFRLLQN-EQMNIFINLTREEW--MELRSLVVEMVLSTDMSSHLLQVKAMKACLQQQER-IDKP KALSLLLHTADISHPSKPWPLHSRWTKALMEEFFQQGDREAELGLPFSPLCDRKSTLVAESQIG------FIDFIVYPTF SLLTDMAEKVVIPLVEENPGPPD-------------------------------PCNRHSNLWRESSRGLQWSLAHITAE LVSFRSTWTRHTEDNKFKWKESGSNGMS---------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Human_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---TKEIEEFE----------------------------------SNSLKYLQ----------- --------------PEQIEKIWL--------------------------------------------------------- ------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPR--FKSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIEALKD------VDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA ILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF TVLTDMTEKIVSPLIDETSQTGGTGQRRS--SLNS---------------ISSSDAKRSGVKTSGSEGSAPINNSVISVD YKSFKATWTEVVHINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEQQKEMEA KSQAE---EGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKT DDSQE--------------------------------------------------------------------------- --------------- >Mouse_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---TKEIEEFE----------------------------------SNSLKHLQ----------- --------------PEQIEKIWL--------------------------------------------------------- ------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPR--FKSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIDALKD------VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA ILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF TVLTDMTEKIVSPLIDESSQTGGTGQRRS--SLNS---------------INSSDAKRSGVKSSGSDGSAPINNSVIPVD YKSFKATWTEVVQINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEKQKEMEA KSQAE---QGTTSKGEKKTSGEAKSQVNGTR--KGDNPRGKNSKGEK-AGEKQQNGDLKDGKNKADKKDHSNTGNESKKT DDPEE--------------------------------------------------------------------------- --------------- >Rat_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MTDT---SHKKEGFKKCRSATFSIDGYSFTIVANEAGDKNARPLARFSRSKSQNCLWNSLIDGLTGNV KEKPRPTIVQDTRPPEEILADELP-------------------------------------------------------- ------------------------QLDSPEALVKTSFRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPR--FKSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIDALKD------VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA ILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF TVLTDMTEKIVSPLIDETSQTGGTGQRRS--SLNS---------------INSSDAKRSGVKSSGSEGSAPINNSVIPVD YKSFKATWTEVVQINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEKQKEMEA KSQAE---QGTTSKAEKKTSGETKGQVNGTRTSKGDNPRGKNSKGDK-AGEKQQNGDLKDGKNKADKKDHSNTGNESKKA DGTKKRSHGSPAPSTSSTSRLTLP--------------VIKPPLRHFKRPAYASS-SYAPSVPKKTDDHPVRYKMLDQRI KIKKIQNISHHWNKK >Cow_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---TKEIEEFE----------------------------------SNSLKYLQ----------- --------------PEQIEKIWL--------------------------------------------------------- ------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAASVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIEALKD------VDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA ILYNDRSVLENHHLSAAYRLLQEDEEMNILINLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP KALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF TVLTDMTEKIVSPLIDEPSQTGGTGQRRS--SLNN---------------ISSTDAKRSGVKSSGSEGSAPINNPVIPVD YKSFKATWTEVVHINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEKQKEMEA KSQAE---ESASGKAEKKTSGEAKNQVNGTRTNKSNNPHGKNSKTEKSSGEKQQNGDLKDGKNKTGKKDQSDVGNDSKKT DGKSIIPIIFFHKMCNLMQAC----------------------------------------------------------- --------------- >Dog_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MAKMLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIEALKD------VDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA ILYNDRSVLENHHLSAAYRLLQEDEEMNILINLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEV-IEKP KALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF TVLTDMTEKIVSPLIDETSQTGGIGQRRS--SLNS---------------ISSADAKRSGVKSTGSEGSAPINSSVIPVD YKSFKATWTEVVHINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEKQKEMEA KSQAE---EGAAGKTEKKTSGEAKNQVNGTRTNKSDNPRGKNSKSEKSSGEKQQNGDLKDGKNKTDRKDQSNVGSDSKKT DDSEE--------------------------------------------------------------------------- --------------- >Horse_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---TKEIEEFE----------------------------------SNSLKYLQ----------- --------------PEQIEKIWL--------------------------------------------------------- ------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG IFVERMYRRTSNMVGLSYPAAVIEALKD------VDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA ILYNDRSVLENHHLSAAYRLLQEDEEMNILINLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP KALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF TVLTDMTEKIVSPLIDETSQTGGTAQRRS--SLNN---------------ISSADAKRSGVKSTGSEGSAPINNSVIPVD YKSFKATWTEVVHINRERWRAKVPK------------------------------EEKAKKEAEEKDRLAAEEKQKEMEA KSQAE---EGAAGKAERKTSGETKNQVSGTRTNKSDNPRGKNSKAEKSSGEKQQNGDLKDGKNKTEKKDQSNVGNDSKKT DGTKKRSQGSPAPSTSSASRLTLP--------------VIKPALRHFKRPAYASS-SYAPSVPKKTDEHPARYKMLDQRI KMKKIQNISRTWNRK >Opossum_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---IREIEEFE----------------------------------SNSLKYLQ----------- --------------PEQIEKIWL--------------------------------------------------------- ------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEHAASVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIEALKD------VDKWSFDVFTLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA ILYNDRSVLENHHISAAYRLLQEDEEMNILSNLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IDKP KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF TVLTDMTEKIVSPLIDEPSQPGGPGHRRS--SLNS---------------ISPSDAKRSSVRSTGSEGSASINNNVLTVD YKTFKTTWTEVVHVNRERWRAKIPK------------------------------EEKAKREAEEKAKQEAEEKKKEMEA KSQAES--EGAPGKPEKKKSGEGKSQANGGRPNPPGKP---ASKGDKAAHAG-------DDKNKTDKKDQSNAGNDSKKA DEPEKRPTNGGKYVETIGPK------------------------------------------------------------ --------------- >Platypus_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MIFRFPPAALYDSS---TRAKEADS--------------------------------GGSKSQNCLWNSLIDGLTGNV KEKAKAAIIHDPRAPEEILADDLP-------------------------------------------------------- ------------------------QLDSPEALVKTSFRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIEALKN------VDKWSFDVFTLNDASGDHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---SA ILYNDRSVLESHHVSAAYRLLQEDEEMNILSNLSKDDW--REFRALVIEMVMATDMSCHFQQIKAMKSALQQPEE-IDKP KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF TVLTDMTEKIVTPLLDEPPQTGATGYRRS--SLNN---------------LSPSEAKRCSVKSTGSEGSTSLNSSVLAVD YKTFKATWTEVVHVNRERWKAKVPKG-----------------------------ELQGDKDKMEQSGFGSDSK------ ----------------KTDAFSATGSVDASEHEDGCEWRGPTKAGNSTSIYVL--------------------------- -------------------------------------------------------------------------------- --------------- >Zebrafinch_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---TKEIEEFE----------------------------------NNSLKYLQ----------- --------------PEQIEKIWL--------------------------------------------------------- ------------------------RLRGLRKYKKTSQRLWSLLKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDDLSDIQSDSLPSEVRDWLASTFTRQMGMMLKRTEEKPR--FRSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIGVLKN------VDKWSFDVFALNDASGDHALKFIFYELLTRYDLINHFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVAQTVHYLLFKTGTVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSD---SA ILYNDRSVLENHHVSAAYRLLQDDEEMNILSNLSKDDW--REFRALVIEMVLATDMSCHFQQIKAMKNALQQPEG-IDKS KALSLLLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNSTMVAQSQIG------FIDFIVEPTF TVLTDMTEKIVTPLIDEASLSGMSGFRRS--SLNS---------------ISPSEVKRSSVKSTGSEGSASLNCSILTVD FKSFKATWTEVVQQNREKWKAQATK------------------------------EEKAKKEAEGNAYQGTDKKERDEQD GKPDEDVTERKTEKSKEPNPGEST-RTDSSKNPGNGTWQRGMSKREAYQGGNATRTDKKMDHHHTLGEEKQHVQNGELTE DNKLDRKEV----------------------------------------------------------------------- --------------- >Chicken_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---TKEIEEFE----------------------------------SNSLKYLQ----------- --------------PEQIEKIWL--------------------------------------------------------- ------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPR--FRSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIGVLKN------VDKWSFDVFALNDASGDHALKFIFYELLTRYDLINRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLFKTGVVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSD---SA ILYNDRSVLENHHVSAAYRLLQDDEEMNILSNLSKDDW--REFRALVIEMVLATDMSCHFQQIKAMKNALQQPEG-IDKP KALSLLLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF TVLTDMTEKIVTPLIDEASRSGMSGFRRS--SLNS---------------ISPSEVKRSSVKSTGSEGSASLNCSILTVD FKCFKATWTEVVQQNREKWKAQATK------------------------------GEIKEDCMADKKDQ----------- -------------------SGVGS-ESKKTDGYIHRYFKK--TDVVAWYLGHMASGDQQVTTKFTG--------HHNLTS DIVLHLLY------------------------------------------------------------------------ --------------- >Anolelizard_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---TKEIEEFE----------------------------------SNSLKYLQ----------- --------------PEQIEKIWL--------------------------------------------------------- ------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LLDTEDELSDIQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPR--FRSIVHAVQAG IFVERMYRRTSNMVGLSYPPAVIAVLKN------VDKWSFDVFALNDASGEHALKFIFYELLTRYDLISRFKIPISALVS FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLFKTGVVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSD---TA ILYNDRSVLENHHLCAAFRLLQDDEEMNILSNLSKDDW--REFRTLVIEMVLATDMSCHFQQIKAMKNALQQPEG-IDKP KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVPQSQIG------FIDFIVEPTF TVLTDMTEKIVTPLIEEASHSGMTGFRRS--SLNS---------------ISPSEVKRSSVKSTGSEGSASLNCSILTVD FKCFKTTWTELVQQNREKWKAQATK------------------------------EEKTKKETEENAQQGADEKKTEERE GK-----------KQAEESSGTKT-DKKASKSSVNGTHQTGDNKHEASQGKNITQVEKESESNPTAGQQKQ-VQNGELKN DNKSESKNQGNELRKSEGSKQHMKTAPVPDSTNRLTLPVIKPPMHHLKKPNFASTSTTLPPFHMKTEDSLMKYKLLDQRD RMKKIQHISHHWNRK >Zebrafish_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MSELSSKKQGFKKCRSATFSIDGY SFTIGKNSWSASLATPPMRHRCFCLHS----------------------------------YRETGFFL----------- --------------PDRADSLYRLPGAQHSPGLVHAAH------------------------------------------ ------------------------DLTDCRHVAKAPLRLRCLVKQLE-RGEASVVDLKKNLEYAASVLESVYIEETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPR--FRSIVHAVQAG IFVERMYRRTSNMVGLSYPPSVITALKH------VDTWSFDVFTLNDASGDHSLKFIFYELLTRYDLINRFKIPVSALVS FVEALEVGYGKHRNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMLFAAAVHDYEHTGTTNNFHIQTRSD---TA ILYNDRAVQENHHVSAAYRLLQEDDEMNILYNLSKDDW--RELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEG-IDKP KALSLLLHTADISHPAKNWNMHYRWTTSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF TVLTDMIEKIMTPLIEEASPAGLAGFRRS--SLNN---------------IPSD-GKRSSVRSTGSEGGTSVNSSINAVD FKTFKSTWNEEVHKNREKWKAQAAKDL----------------------------EEKAKQEEMEENEKKKDTDTQSSDD NTKTEDKINTDSNAKSPDKQKEDTRPEKDSKTDQEDSGKAKVDNKEPTEQQPREKEGNKDPGGMNGAQTPSDGKEPETSS DTDNSQRVHNGSEELNSPDSDDSESKRSYDVSQWKRRSKCAKYLLSSADSEDEHSNCGISPSSDSAAAASAPHAD----- --------------- >Fugu_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MESP---TKEIEEFE----------------------------------STALKYLQ----------- --------------PEQIEKIWLR-------------------------------------------------------- -------------------------LRGLRKYKKTSQRLRCLVKQLE-RGEASLNDLKKNLEYAASVLESVYIEETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LVDTEDELSDIQSESVPSEVRDWLASTFTRQMGLMLRRNEEKPR--FRSIVHAVQAG IFVERMYRRTSNMVGLSYPPSVISVLKN------VDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISSLVS FVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSD---TA ILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDW--RELRALVVEMVLATDMSCHFQQVKAMKNFLQQPEG-IDKP KALSLLLHTADISHPAKNWDLHHHWTTSLLEEFFRQGDKEADLGLPFSPLCDRKSTMVAQSQIG------FIDFIVVPTF TVLTDMMERIVTPLIDEASHSGFAGFRRS--SLNS---------------ISSEEAKRQSVKSVGSDSSSSGPGSLLTVD IKNFKAMWNEEVYQNRERWKAQACKEA----------------------------EERAKREAEEQTQQEVEEEEPKSEA SSSPQEANTGKMEQ------------------------------------------------------------------ -------------------------------------------------------------------------------- --------------- >Medaka_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------S----------------------------------KEEK--------------- -------------------------------------------------------------------------------- --------------------------------VQVRLILRCLVKQLE-RGEASLNDLKKNLEYAASVLESVYIEETRR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRNEEKPR--FRSIVHAVQAG IFVERMYRRTSNMVGLSYPASVISVLKN------VDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISAVVS FVEALEVGYNKHKNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSD---TA ILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDW--RELRALVVEMVLATDMSCHFQQVKAMKNFLQQPES-IDKP KALSLLLHTADISHPAKSWDLHHRWTTSLLEEFFRQGDKEADLGLPFSPLCDRKSTLVAQSQIG------FIDFIVVPTF TVLSDMMERIVTPLIEEASHSGLAGF------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Honeybee_PDE1C -------------------------------------------------------------MIDFTHHDLIQ-------- -----------IKKVNIDSQFQFHRGLGRR--------------------CREVLSCAKKRLQKSAE------VASPPDR RATRDDIAVSSPGASPNVN--ATTS----------------------CTGT---------TSSRLHNPSSPGR------- -----NGQLSKQGTLTIVRRSSGKN----------------------------------------KSIGGSFESSPPPHS PDT--------LSSSQSVDL--------DEILDNVDLT------------------------------------------ -------------------TDSLPAVDTPDACDKAALRLRCLLRQLQ-HGEISAELLQRNLHYAARVLEAVFLDETKD-- -----YINATTRYRPLD--------AEIIISQKQVSQRGC------------SIDS----ISSQPMNPSPGTG------- --------------------------------------LSSASLG-------------SALDSDGQQGHA---------- VVTQKRKLRTPVWARLLSTNKTRLADEDDELSEVQPDAVPPEVREWLASTFTRQLATTRRKADEKPK--FRSVAHAIRAG IFVDRIYRRVTNTALMQFPQEVVKVLKT------LDDWSFDVFSLNEAAMGAPVKYLGYDLLNRYGMIHKFKVPATVLEC FLGRVEEGYCRHRNPYHNNLHAADVAQTMHYILCQTGLMNWLTDLEIFATLVAAIIHDYEHTGTTNNFHVMSGSD---TA LLYNDRAVLENHHISASFRIMRE-DECNILQNLSREEF--REFRSLVIDMVLATDMSFHFQQLKNMKNILSLAEPSVDKS KAVSLVLHCCDISHPAKRWDLHHRWTMQLLEEFFRQGDKEKALGLPFSPLCDRNNTLVAESQIG------FIEFIVEPSM QVCSDMLETVLTPLN-------------------------------VKESVDESNNG-----------------SGGESR RFKIGKPWIPCLAENKRIWK-----------------------------------EQAVRGIWNKILVRCVEFDIVVLKR NT------------------------------------------------------------------------------ -------------------------------------------------------------------------------- --------------- >Drosophilamelanogaster_PDE1C MGDTLDETPPTRRDKPQTLNIGQEEQGSDPASGNTSSPVSSIAIPAARVPRHRLRHADRDQKRDHSSDGLVSSGELRDEF MGIDAQPRRESLNSCEVGSPGTMSSSLGKAGRLNSSRYPSGGAGAIGLSVMGNLVGTTTRKCVLTLDGYSYVIVASTPES LPSKRDEASGGPGSSGGTSGAATSSSSSGGGAASGAASGSVGPASGTATGTGSASGGAGGVSTPAQEAASPTVSELSGSG SNATINGQVARHGSLTIIRRTNSRNFTQFDGQLASPSSTACSSTAPGIGFAQTPLSEPLAERLSFRASGGSNGSASAGDS RSSNQGPSNSGPAASAAVKMQPSSPNATNYLADNIQISSANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQE SGHSFETPSNMSFTAGQWDTESLPPVDTPDALNKAAGRIRSLLRRMD-HETVAYEDMQRNLHYAARVLEAVFIDESREGC NGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSS ETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSAGSSGSCSNPA AVHRQRRLRTPTWARSMSTNKTRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPK--FRSVAHAIRAG IFVDRMYRRVSSSALTAFPPDVVRLLKN------LDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEA FLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSE---TA LLYNDRAVLENHHASASFRLLRE-DEYNILSHLSREEF--RELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQ KVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQIC------FIDFIVEPSM GVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTAS KFNIPKPWLTCLVENKRIWK-----------------------------------EQAVKDAEARALATAAEEAAAAAAA EAEESKPETETADGEQSEPAAEPADGAAA--------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Seaurchin_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------MEGKPNP TEKGKSHVANPPNNA----------------------------------------------NANKESPGSPRAR------ -------VEGKKMEYRIIKKTDTKR-----------------------------------------RLRRQESQSMDEES LAS-------------------------IDLEVS---------------------------------------------- --------------------ESMPPATSPQGAVLAALRLRSLVLRLE-REEISKKYLKENLEYAASVLDTLKQDEASR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------YHYHEEEDDLSEVTSDEVPEQVRHWLTSTFSRQSTKSRLG-DEKPR--FRSIVQALRTG LFIDRMFRRTSATAGTVLPAKVIQIFKTIDDWSFVDDWSFDIFLLDTETDGHALKFLATEVLSRYDLQTKFKIPHSVLGA FLDAMELGYSKYGNPYHNLLHAADVTQTVHHMLARMGLVHWLSDLEIFASLLAAIIHDFEHTGTTNAFHVNTKSD---MA MFYNDRAVLENHHISSSFRLMRD-DERNILANLSKEEY--TELRNLVIDMVLATDMSFHFQQIKQMKSMISTTEA-LDKP KVMALTLHCADISHPSKEWKFHYKWTTLLIREFFRQGDREREMGLPISPLCDRNSTLLAESQIG------FIDFIVDPSM NICGDMIDRILREELNSASNSPSADSVVRNKRNSIPMAR--PCSAPRSASVPAPANNNSMNDRDRPSSPGRVSIGRRNSI PVRCLRSWHENLHKNKSKWRDFGQQEHTGVKVLDI------------------DEDPIVQKPNKDVFHKSDTNDDSAARK TSNANGIEEEEAPHDQATTSGSTAGAAESSGSAHAPGRQGSGER------------------------------------ -------------------------------------------------------------------------------- --------------- >Anophelesgambiae_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------QTQNNRRLADEDDELSEVQPDAVPPEVREWLASTFTRQLATTRKKSDEKPK--FRSVAHAIRAG IFVDRIYRRVSSTALMQFPPEVVRVLKT------LDDWSFDVFALAEAGNCQPVKYLGYDLLNRYGMIHKFKVPPATLET FLTRIEEGYCRFRNPYHNNLHAADVAQTVHHVLCQTGLMHWLTDLEIFATLLAALIHDYEHTGTTNNFHVMSGSD---TA MLYNDRAVLENHHISAAFRVLKE-DDCNVLQNLSRDEF--RELRTLIIDMVLATDMSFHFQQLKNMRNLLTLAEPQVDKS KALSLVLHCCDISHPAKRWDIHHKWTMLLLEEFFRQGDLERELGLPFSPLCDRNNTLVAESQIG------FIEFIVEPSM TVCADMLEIVLAPIA-------------------------------PI-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Cionaintestinalis_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------E-SNSVSSEHIRQNIEYAIAVMESRYVNRIAD-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------ISDDEVPATLSGEGPVPPEIKRWLVQTFTS---HTRNRKESENKRSLRSVVHAVQAG MFVDRMFRKTSVGPMFKTYSKVTYSIQN------IDSWSYNVFELERISEGNSLKFVFYELLNKYDLIRKFKIPLKSLFA YCTKLQRGYRKHNNRYHNPIHAADVAQSLNCLLVNSGFVHWLSDVEMFSMIMAAIVHDLEHSGTTNTFHTNTRSP---LA QMYNDKSVLENHHISSAFRLLNE-EDCDILANFSKDDY--QEARTLMIDMVLATDMSQHFGQLKRLQSNLQHPEN-LEKS RAMCLMIHSADINHPSKPWNLHCRWTERLVVEFFEQGDQERGLGLPLSPLCDRHTTMVAQSQIG------FIDYVIKPTF DVLYDI-------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Cionasavignyi_PDE1C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------EHIRRNIEYAIAVMESRYVNRVVE-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------IPDDEVPATLSGEGPVPPEIKRWLVQTFTSRRADVRGRKESETRRSLRSVVHAVQAG MFVERMFRKTSVG-VQNLPPEVQEHFKN------IDSWSYDVFELDRISDGNSLKFVFYELLNKYDLIRKFKIPLKSLFA YSARLQRGYRKYNNRYHNPIHAADVAQSLNCLLVSSGFVHWLSDLEMFSMIMAAVVHDLEHSGTTNTFHTNTRSP---LA QMYNDKSVLENHHISSAFRLLNE-EDCDILVNFSKDDYPSKEARTLMIDMVLATDMSQHFGQVKKLQSNLQHPES-LEKS RAMCLMIHSADINHPSKQWELHCRWTERLVVEFFEQGDQERKLGLPLSPLCDRHTTMVAQSQIG------FMDYVIKPTY DVLFDIFRNVNGPVVRDAILSLRRAS------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Amphixous_(1) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MSCGILHVCLH--------------RK-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------LVPDEDDLSEVEPDAVPTEVRDWLASTFTRQMQVSTRARTEKPR--FRSIVQAVRAC NRVDRLCRK-LSGSGVNYPPGVVNLLKN------LDDWSFDVFAVNVASNSQALRYVAYEVLKTYDLLVKFKINSGVLFK FLDALESGYGKHSNPYHNQLHAADVTQTTHYLLYSTGLVQWLADVEILAVVLSAAIHDVEHTGETNSFHVMSKDVWCIRT MLYNDRAVLENHHISTNESWVSASQMSQMGT-----------LRTLTIDMVLATDMSFHFQQVKQIKSLLSCPES-IDKS KALSLLLHTADIGHPAKPWHLHARWTEQLMEEFFRQGDKEKALGLPFSPLCDRNTTVIADSQIG------FIDFIVDPTF QVMGDMLEKILTPLAP---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------- >Amphixous_(2) -------------------------------------------------------------------------------- ---------------------------------MFSSFYEFLLFLYDVAIVCIMVMCVIYINYVIVTRWIPVLIGFAWRL VQEYLPPHISRKGDIILTQIEADYYAFIDWFEGLRYKLKEWWYREPVVEPVEEDSGEERRRSSVDLSLITAMITSQTASS EEKQNGGQTIVKVANSGEKNAVENDTQGCSVQP-------------------------LKASSSNESVSGKRLTPRKKGS PPRRQGPSKEDLTMSLELCTDNLP-------------------------------------------------------- ------------------------PTDSLEALEKASKRIRKICTFLQSRGNVPSNLLKRNLHYIADVLEIVATDDARR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------FIDEDDELSEVEPDAVPMEVRDWLASTFTRSASVTKSGEKEKKT--FRSIVQAVRAA N---------LS----------------------LDDWSFDVFALNEATNGQALRYVTYEIMMRYDLLAKFKIGVGTLFN FLEALEVGYSKYQNPYHNLVHGADVTQTMHSILFQTGLVQWLTDVEIFAVVFSAAIHDFEHTGETNNFHVMSRD------ ------------------------------------------FRTLVIDMVLATDMSYHFAQVKQMKSLLSCPDN-IDKA KALSLVLHTADISHPAKNWTLHEHWTELLMEEFFRQGDKEQELGLPFSPLCDRKTTMVASSQIGKYSKGGFIDFIVQPSF EIMSDMLDKVVAPISPRGSLANQSSATIS--------------------------------EKVEAEGSPQNGDQSEEPF EFKVDRVWDGHLTGNKVKWKEQSTKDQAEKEAR----------------------EKAAQKAKEDAEKRDQSPLDDKAEE KKDAENPPKITANGTVSPGNAVDLKVKPSTSPENDDQVSTKEEAVGTASPEHAEKRTTEEDKPGKIESITVKSVTKRKES GV------------------------------------------------------------------------------ --------------- >Jelly_fish_(1) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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