>Homo_sapiens_KDM4A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MASESETLNP-------------------------------------------------------SARIMTFYPTMEEFR NFSRYIAYIESQGAHRAG-------------------------------------------------------------- ---------LAKVV------------------------------------------------------------------ -------------------PPKEWKPRA-------------------------------------SYDD----------- ------------------------------------------------------------IDDLVIPAPIQQLVTGQS-- -----------GLFTQYNIQKKAMTVREFRKIANSD---KYCTPRYSE-FEELERKYWKNLT---FNPPIYG-ADVNGTL Y-----------------EKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWY---SVPPEHGKRLERLAKGFFPGS---AQSCEAFLRHKMTLISPLMLKK-YGIPFDKVTQEAGE-FMITFPYGY HAGFN-HGFNCAESTNFATRRWIEYGKQAVL--CSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAE FLKESE-----------LPPRAGNEEECPEED----------------MEGVEDGEEGDLKTS------LAKHRIGTK-- -----------------------------RHRVCLEIPQEVSQSELFPKED---------------------LSSEQYEM TECPAA------LAPVRPTHSSV--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------RQVEDG-------------------------------- -------------------------------------------------------------------------------- ---------LTFPDYS-----------------------------------------------------DSTEVKFEELK NVKLEEEDEEEEQA---AAALDLSVN------------------------------------------------------ ----PASVGGRLVFSGSKK-----------------------------------------------KSSSSLGSGSS--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------RDSISSDSETSE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------PLSCRAQ----------- ---------------GQTGVLTVHSYAK---------GDGRVTVGEPCTRKKGSAARSFSERELAEV------------- ADEYMFSLEENKKSK----------------GRRQPLSKLPR--HHPLVLQECVSDDETSEQLTPEEE---------AEE TEAWAKPLSQL---WQNRPPN-------------------------FEAEKEFNETMAQQAPHCAVCMIFQTYHQVE--- -------FGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCS----TDINLSTPYLEEDGTSILVSCKKCSVRVHASCY GVPPA---------KASEDWMCSRCS----ANALEEDCCLCSLRGGALQR-ANDD------------------------- -----------------------RWVHVSCAVA----------ILEARFVNIAERSPVDVSKIPLPRFK----------- ---------LKCIFCKKR-RK-RTAGCCVQCSHGR-CPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHK-----IPNLE R-AKGALQ-SITAGQKVISKHKNGRFYQCEVVRLTT--------------ETFYEVNFDDGS----------------FS DNLYPEDIVS-QDCLQFGPPAEGEVVQVRWTDGQVYGAKFVAS--------HPIQMYQVEFEDG-SQLVVKRDDVYTLDE ELPKRVKSRLS--VASDMRFNEIFTEKEVKQEK-KRQRVINSRYREDYIEPALYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Pan_troglodytes_KDM4A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MASESETLNP-------------------------------------------------------SARIMTFYPTMEEFR NFSRYIAYIESQGAHRAG-------------------------------------------------------------- ---------LAKVV------------------------------------------------------------------ -------------------PPKEWKPRA-------------------------------------SYDD----------- ------------------------------------------------------------IDDLVIPAPIQQLVTGQS-- -----------GLFTQYNIQKKAMTVREFRKIANSD---KYCTPRYSE-FEELERKYWKNLT---FNPPIYG-ADVNGTL Y-----------------EKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHKEDMDLYSINYLHC- -------------------------FFPGS---AQSCEAFLRHKMTLISPLMLKK-YGIPFDKVTQEAGE-FMITFPYGY HAGFN-HGFNCAESTNFATRRWIEYGKQAVL--CSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAE FLKESE-----------LPPRAGNEEECPEED----------------MEGVEDGEEGDLKTS------LAKHRIGTK-- -----------------------------RHRVCLEIPQEVSQSELFPKED---------------------LSSEQYEM TECPAA------LAPVRPTHSSV--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------RQVEDG-------------------------------- -------------------------------------------------------------------------------- ---------LTFPDYS-----------------------------------------------------DSTEVKFEELK NVKLEEEDEEEEEE---AAALDLSVN------------------------------------------------------ ----PASVGGRLVFSGSKK-----------------------------------------------KSSSSLGSGSS--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------RDSISSDSETSE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------PLSCRAQ----------- ---------------GQTGVLTVHSYAK---------GDGRVTVGEPCMRKKGSAARSFSERELAEV------------- ADEYMFSLEENKKSK----------------GRRQPLSKLPR--HHPLVLQECVSDDETSEQLTPEEE---------AEE TEAWAKPLSQL---WQNRPPN-------------------------FEAEKEFNETMAQQAPHCAVCMIFQTYHQVE--- -------FGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCS----TDINLSTPYLEEDGTSILVSCKKCSVRVHASCY GVPPA---------KASEDWMCSRCS----ANALEEDCCLCSLRGGALQR-ANDD------------------------- -------------------------------------------------------------------------------- ----------KCIFCKKR-RK-RTAGCCVQCSHGR-CPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHK-----IPNLE R-AKGALQ-SITAGQKVISKHKNGRFYQCEVVRLTT--------------ETFYEVNFDDGS----------------FS DNLYPEDIVS-QDCLQFGPPAEGEVVQVRWTDGQVYGAKFVAS--------HPIQMYQVEFEDG-SQLVVKRDDVYTLDE ELPKRVKSRLS--VASDMRFNEIFTEKEVKQEK-KRQRVINSRYREDYIEPALYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Mus_musculus_KDM4A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MASESETLNP-------------------------------------------------------SARIMTFYPTMEEFR NFSRYIAYIESQGAHRAG-------------------------------------------------------------- ---------LAKVV------------------------------------------------------------------ -------------------PPKEWKPRT-------------------------------------SYDD----------- ------------------------------------------------------------IDDLVIPAPIQQLVTGQS-- -----------GLFTQYNIQKKAMTVREFRKIANSD---KYCTPRYSE-FEELERKYWKNLT---FNPPIYG-ADVNGTL Y-----------------EQHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWY---SVPPEHGKRLERLAKGFFPGS---AQSCEAFLRHKMTLISPLMLKK-YGIPFDKVTQEAGE-FMITFPYGY HAGFN-HGFNCAESTNFATRRWIEYGKQAVL--CSCRKDMVKISMDVFVRRFQPERYKLWKAGKDSMVIDHTLPTPEAAE FLKDSGG----------LTPRAGSEE-CPEED----------------VEAADQGEEGDVKRS------LAKHRIGTK-- -----------------------------RHRVCLEIPQEVSQSELFPKEE---------------------LSSGQYEM TECPAT------LAPVRPTHSSV--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------RQVEDS-------------------------------- -------------------------------------------------------------------------------- ---------LPFPDYS-----------------------------------------------------DPTEVKFEELK NVKLEEEDEEDEPE---AAALDLSVN------------------------------------------------------ ----PASVGGRLVFSGSKK-----------------------------------------------KSSSSLGSTSS--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------QDSVSSDSETAE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------SVSCQGQ----------- ---------------EKTGVLTVHSYAR---------GDGKAATGEPSVKKKRSAPRSISEQELAEV------------- ADEYMLSLEENKKTK----------------GRRQPLSKLPR--HHPLVLQECGSDDETSEQLTPEEE---------AEE TEAWAKPLSQL---WQNRPPN-------------------------FEAEKEFNEIMAQQAPHCAVCMIFQTYHQVE--- -------FGAFSQSCGDASEPAAQTQRTKPLIPEMCFTTTGCS----TDINLSTPYLEEDGTSMLVSCKKCSVRVHASCY GVPPA---------KASEEWMCSRCS----ANALEEDCCLCSLRGGALQR-ANDD------------------------- -----------------------RWVHVSCAVA----------ILEARFVNIAERSPVDVSKIPLPRFK----------- ---------LKCVFCKKR-RK-RNAGCCVQCSHGR-CPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHK-----IPNLE R-AKGALL-SITAGQKVISKHKNGRFYQCEVVRLTT--------------ETFYEVNFDDGS----------------FS DNLYPEDIVS-QDCLQLGPPAEGEVVQVRWTDGQVYGAKFVAS--------HPIQMYQVEFEDG-SQLVVKRDDVYTLDE ELPKRVKSRLS--VASDMRFNEIFTEKEVKQEK-KRQRVINSRYREDYIEPALYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Canis_familiaris_KDM4A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MASESETLNP-------------------------------------------------------SARIMTFYPTMEEFR NFSRYMAYIESQGAHRAG-------------------------------------------------------------- ---------LAKVV------------------------------------------------------------------ -------------------PPKEWKPRA-------------------------------------SYDD----------- ------------------------------------------------------------IDDLVIPAPIQQLVTGQS-- -----------GLFTQYNIQKKAMTVREFRKIANSD---KYCTPRYSE-FEELERKYWKNLT---FNPPIYG-ADVNGTL Y-----------------EKHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWY---SVPPEHGKRLERLAKGFFPGS---AQSCEAFLRHKMTLISPLMLKK-YGIPFDKVTQEAGE-FMITFPYGY HAGFN-HGFNCAESTNFATRRWIEYGKQAVL--CSCRKDMVKISMDVFVRKFQPERYKLWKAGKDSTVIDHTLPTPEAAE FLKESE-----------LAPRARNEE-CPEEDD---------------MEGLEDGEEGDFKRS------LAKHRIGTK-- -----------------------------RHRVCLEIPQEVSQSELFPKEE---------------------LSTGQYDM TECQAA------LAPVRPTHSSV--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------RQVEDN-------------------------------- -------------------------------------------------------------------------------- ---------LPFPDYS-----------------------------------------------------DSSEVKFEELK NVKLEEEDEEEEEE-QEAAALDLSVN------------------------------------------------------ ----PASIGGRLVLSGSKK-----------------------------------------------KSSSSLGSSSS--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------RDSISSDSETSE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------PLSCRAQ----------- ---------------GQSGVLTVHSYAK---------GDGRVVMGEPCTRKKGGATGSISERELAEV------------- ADEYMFSLEENKKSK----------------GRRQPLSKLPR--HHPLVLQDCVSDDESSEQLTPEEE---------AEE TEAWAKPLSQL---WQNRPPN-------------------------FEAEKEFNETMAQQAPHCAVCMIFQTYHQVE--- -------FGGLSQSCGNTSALAPQKQRTKPLIPEMCFTSTGCS----TDINLSTPYLEEDGTSLLVSCKKCSVRVHASCY GVPPT---------KASEDWMCSRCS----ANALEEDCCLCSLRGGALQR-ANDD------------------------- -----------------------RWVHVSCAVA----------ILEARFVNIAERSPVDVSKIPLPRFK----------- ---------LKCVFCKKR-RK-RTAGCCVQCSHGR-CPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHK-----IPNLE R-AKGALQ-SITAGQKVISKHKNGRFYQCEVVRLTT--------------ETFYEVNFDDGS----------------FS DNLYPEDIVS-QDCLQLGPPAEGEVVQVRWTDGQVYGAKFVAS--------HPIQMYQVEFEDG-SQLVVKRDDVYTLDE ELPKRVKSRLS--VASDMRFNEIFTEKEVKQEK-KRQRVINSRYREDYIEPALYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Gallus_gallus_KDM4A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MASELESLNP-------------------------------------------------------SARIMTFRPTMEQFR DFSRYIAYVEAQGAHRAG-------------------------------------------------------------- ---------LAKVR------------------------------------------------------------------ -------------------RGEAGPERK-------------------------------------CYDD----------- ------------------------------------------------------------IDELVIPAPIQQVVTGQS-- -----------GLFTQYNIQKKAMTVREFRRIANSD---KYCTPRYTD-FEDLERKYWKNLT---FNAPIYG-ADVNGTL Y-----------------DKHVDAWNIGRLNTILDVVENESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWY---SIPPEHGKRLERLAKGFFPGS---AQSCEAFLRHKMTLISPSILKK-YGIPFDKVTQEAGE-FMITFPYSY HAGFN-HGFNCAESTNFATLRWIEYGKQSVL--CSCRKDMVKISMDVFVRKYQPDRYKLWKAGKDVTVIDHALPTPEAAE FLKGDL------------MQKVKSGRQYAEDMET--------------GEACKEEVDGDETKS------VPKHRIGTK-- -----------------------------RHRVCLEVPQEVSESEAFPKEE---------------------LSSMQDEE DAAEPC---------ERATGEVT--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------QQSEQG-------------------------------- -------------------------------------------------------------------------------- ---------HKVPVTSY----------------------------------------------------RVGMAKSEELK VVKLE-EEEEEEQE---AAVLDLSIS------------------------------------------------------ -----HASNSASVLPTSKQ-----------------------------------------------RAPSSVQPSSP--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------AYSGSSDSESTD--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------LLPKRTLP---------- ---------------GPAGVLTVHSYAR---------GDASGSDNE-TSGKKASATGSVNEQELAEV------------- TKEYIQSMKESKKSK----------------GRRQPLSKLPR--HHPLLVKDCISDDEASEQLTPEEE---------AEE TEAWAKPLSQL---WQNRPPN-------------------------FEAEKEYNRTMAQQSPYCAVCMLFQTY-QAE--- -------CGGSSQNSGGTPGAADGKIRTKPLIPEMCFTTTGCS----TDLNLSTPYLEEDGTSVLITCRNCQVCVHASCY GVSPD---------KATEDWMCSRCT----ENALEEDCCLCSLRGGALQR-ANDD------------------------- -----------------------KWVHVMCAVG----------VLEAKFVNIAERSPVDVSKIPLQRFR----------- ---------LKCIFCKKR-RK-RIAGCCVQCSHGR-CPTSFHVSCAQAAGVMMQPDDWPFVVFITCFRHK-----IPSQA ERAKAALQ-DLSPGQIVISKHKNGRFYQCEVVSLAK--------------ETFYEVNFDDGS----------------FS DNLYPEDIVS-RDCLQLGPPAEGEVVQVRWTDGQVYGAKFVAS--------HAIQMYQVEFEDG-SQLMVKRDDVYTLEE ELPKRVKSRLS--IASDMRFTEIFAEKEVRQER-KRQRVINSRYREDYIEPALYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Anolis_carolinensis_KDM4A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MASELENLNP-------------------------------------------------------SARIMTFHPTMEEFK NFSRYIAYIESQGAHRAG-------------------------------------------------------------- ---------LAKVV------------------------------------------------------------------ -------------------PPKEWKPRR-------------------------------------WYDD----------- ------------------------------------------------------------IDDVIIPAPIQQVVTGQS-- -----------GLFTQYNIQKKAMTVREFRRIANSD---KYCTPRYTD-FEDLERKYWKNLT---FNAPIYG-ADVNGTL Y-----------------DKHVDDWNIGHLNTILDVVENESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWY---CVPPEHGKRLERLAKGFFPGS---AQNCEAFLRHKMTLISPSILKK-YGIPFDKVTQEAGE-FMITFPYGY HAGFN-HGFNCAESTNFATLRWIEYGKQSVL--CSCRKDMVKISMDVFVRKYQPDRYKLWKAGKDVTVIDHALPTPEAAE FFKGEL------------LQKVKNEKHCPDDTEL--------------EEECSADG-DIEKKS------MPKHRIGTK-- -----------------------------RHRVCLEVPHEVSQSEAFPKEE---------------------LGPVQFEM DVAESP---------VGPAREPV--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------QQGEQG-------------------------------- -------------------------------------------------------------------------------- ---------IALPEYG-----------------------------------------------------DSSEVKFEELK NVKLD-DEEE-EPE---AAVLDLSIS------------------------------------------------------ -----HSVTST---GIKLQ-----------------------------------------------SSVSSLQSDSP--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------MGSGSSDSEPSD--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------LYRQDLE----------- ----------------QPEVLMVHSYAK---------EEVNDMSSERPSGKKASATTRVNEQDLAKM------------- AKEYIRSVKDHKKSK----------------GRRQPLSKLPR--HHPLLVKDGLSDDEMSEQLNPEEE---------AEE TEAWAKPLGQL---WQNRPPN-------------------------FEAEKEYNAAMAQQAPYCAVCMLFQTY-QAD--- -------CGG--QSSQVVLDAG-GKMRTKPLIPEMCFTTTGCS----TDVSLSTPYLEEDGTSLLVTCKRCRVRVHASCY GVAPE---------KATGDWKCSRCR----ANALEEDCCLCSLRGGALQR-ANGN------------------------- -----------------------KWVHVMCAVA----------VLEAKFVNIAERSPVDVSKIPLQRFR----------- ---------LKCVFCKKR-RK-RTAGCCMQCSHGR-CPTSFHVSCAQAAGVMMQPDDWPFVVFTTCFRHK-----IPSQA ER---ALQ-DLVVGQAVISKHKNGRFYQCEVINLTK--------------ETFYEVNFDDGS----------------FS DNLYPEDIVS-RDCAQLGPPAAGEVVQVRWTDGQIYGATFVAS--------HVIQMYQVEFEDG-SQLMAKRDDVYTLNE ELPKRVKSRLS--VASDMRFTEIFTEKEVKQER-KRQRVINSRYREDYIEPALYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Pelodiscus_sinensis_KDM4A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MTVREFRRIANSD---KYCTPRYTD-FEDLERKYWKNLT---FNAPIYG-ADVNGTL Y-----------------EKHVHEWNIGKLNTILDVVENESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWY---SVPPEHGKRLERLAKGFFPGS---AQSCEAFLRHKMTLISPSILKK-YGIPFDKVTQEAGE-FMITFPYGY HAGFN-HGFNCAESTNFATLRWIEYGKQSVL--CSCRKDMVKISMDVFVRKYQPDRYKLWKAGKDVVPIDHTLPTPEAAE FFKGEL------------LQKVKNGKPSTEEPET--------------GEACQEGVDVDEKKS------LPKHRIGAK-- -----------------------------RHRVCLEVPHEVSQSEAFPKEE---------------------LSPVQYEV EVAAPP---------VRPASERV--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------QQGEDG-------------------------------- -------------------------------------------------------------------------------- ---------LPGSD-EV----------------------------------------------------DSSEVKFEELK PVKLE-EEEEDEQE---VAVLDLSVP------------------------------------------------------ -----HSVSSTSALAVSMQ-----------------------------------------------NPVFSLQPSSP--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------AYSASSDSESAE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------LLPRRTL----------- ---------------GQAGVLTVHSYAR---------GDAAGPGGDHASGKKASVN----EQELAEV------------- AKEYMRSVKESKKSK----------------GRRQPLSKLPR--HHPLVVKDYISDDEMSEQLTPEEE---------AEE TEAWAKPLSQL---WQNRPPN-------------------------FEAEKEYNESMAQQPPYCAVCMLFQTY-QAE--- -------CGGHGQSAAVAPSAATRKVRTKPLIPEMCFTATGCS----TDLNLSTPYLEEDGTSVLITCKTCSVCVHASCY GVSPE---------KATEDWTCSRCT----ANALEEDCCLCSLRGGALQR-ANDD------------------------- -----------------------KWVHVMCAVA----------VLEAKFVNIAERSPVDVGKIPLQRFR----------- ---------LKCVFCKKR-RK-RIAGCCVQCSHGR-CPTSFHVSCAQAAGVMMQPDDWPFVVFITCFRHK-----IPSQA ERAKAALQ-DLSAGQMVISKHKNGRFYQCEVVSLTK--------------ETFYEVNFDDGS----------------FS DNLYPEDIV-------------------------VCGVTGALL--------H---------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------- >Danio_rerio_KDM4A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MAS----DMP------------------------------------------------------VSRGIMTFHPTVEEFK NFSRYIAYMESQGAHKAG-------------------------------------------------------------- ---------LAKIV------------------------------------------------------------------ -------------------PPKNWKPRG-------------------------------------SYDD----------- ------------------------------------------------------------IDDLIIPAPIQQVVTGQS-- -----------GLFTQYNIQKKAMTVKEFRKTANSD---KFCSPRYDD-FEELERKYWKNVT---FNPPIYG-ADVNGTL Y-----------------DPDIKEWNVGHLNTILDTVEHESGITIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFG EPKSWY---TVPPEHGKRLERLAKGFFPGS---SQNCEAFLRHKMTLISPSILKK-YGIPFEKITQEAGE-FMVTFPYGY HAGFN-HGFNCAESTNFATRRWIDYGKQAIL--CSCRKDMVKISMDVFVKKFQPERYELWLEGKDNAPIDHSKPTPEAAE FLGGEA------------GAQELRIE------------------------NQSNEGQKKSLA---------KQRIGTK-- -----------------------------RHRVCLDFPEEVLPKTETND------------------------EAEYGKK GRLTPYT-----------EQCKE--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------YTELKH-------------------------------- -------------------------------------------------------------------------------- ---------EDRTLPLM----------------------------------------------------GSTSLKMLPGS RSAEFSENVRGAGFSDADLDAKATSH------------------------------------------------------ ---ISACAQPFPKHHLSIA----------------------------------------------SVPTVPHCLSAVPRV -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------STKPGVASLLFH--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------RTLSP-------------- -----------------TDALQVHSYAA---------KAALCKPQTPSPEKPREDLHIPDISLDVRP------------- NTPTPPPDTPEHEIEGEKENNS-------MKRKLQPLSKLPR--LHPLLRENSSDDE-IQEPTAEPE------------E TDPWAKILAPM---WQSRQRN-------------------------FQIEKEFNFRMGLHPPYCAVCSLFHTYNES---- -----DVISLG-GFAAVGGNP----QRTKPLIPEMCFTSSS-------EGHLSTPNLEADGTSQLISCSVCSVRVHTSCY GVSQD---------AKLDSWRCSRCE----ANAITQDCCLCSLRGGALQR-ANND------------------------- -----------------------KWVHVLCAVA----------VLEARFVNIAERRPVDLSTIPFQRFK----------- ---------LKCQFCRKW-VK-KTTGCCVQCSHGR-CSTSFHATCAQAAGVQMHPDDWPFVVYFTCWRHK-----GGTHI ERNMASMR-ELEKGQKVICKHKNGRYYHCEVVELTK--------------ATFYEVIFDDGS----------------FS DNLFPEDIVN-RDCTRHGPPSEGEVVQVQWTDGLIYGAKFVSD--------HIIPMYQVEFEDD-SQLTVKREDVFSLDE ELPKRVKSRLS--VASDMRFKGVFVEKEVKQDS-KRQRVINSRYREDYIEPAIYRAILE--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Danio_rerio_KDM4A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MASDSVSQSSQ----------------------------------------------------SPATRIMTFHPTKEEFK DFNRYIAYMESQGAHRAG-------------------------------------------------------------- ---------MAKVV------------------------------------------------------------------ -------------------PPKDWKPRR-------------------------------------TYDD----------- ------------------------------------------------------------IEDLVIPTPIQQVVTGQS-- -----------GLFTQYNIQKKPMTVREFRKTANTD---KFSNPRYAD-FEELERKFWKNLT---FNPPLYG-ADVSGTL Y-----------------DPDVMEWNIGRLNTILDMVERESGITIKGVNTPYLYFGMWKSTFAWHTEDMDLYSINYLHFG EPKSWY---VVPPEHGKRLERLAKGFFPGS---AQSCEAFLRHKMTLISPSILRK-YGIPFEKVTQEAGQ-FIVTFPYGY HAGFN-HGFNCAESTNFATQRWIDYGKLATL--CSCRKDMVKISMDVFVHKFQPERYKLWKAGKDNVPIDHSKPTPEVAE IQKENEKGEISDS----ERAETLEERGEAEAGDQ--------------QKANTDDGEEDKAEAFSEKVVKRESDAGKEKA EAEVEKSV---------------------RDEEPSSTSEQISSSSPKQNTGQKRLRSSTDNEAKDDNQVKIEVEEVEKKK AKLGQNETDNNEEQSVSAEPDDE--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------KAEETM-------------------------------- -------------------------------------------------------------------------------- ---------ETDTPPPQ----------------------------------------------------QQECMEAELST SDPTSSSDITTQQREEESSDVTSSTQSINSVDEDVALGGDVASQSEDVTQSFVVQINPEDITPTDLTDAQPSNITSHPCS SDIPATSFMSVSSSNFSKHSISFAYTCDGTTEPSDSINLTPRVPSINVAHISDVQPEPSDIIVSLKQNSSANSTYTSDVQ SDLSNVTVDPEHKPSINSTHIINVQSETSNITISSEHEPSISSTPMSDVQSETSFKYEPGNNSAYVCDVKPEHSDISMSP IYKPGVNFAHTSDVQPEPSECESCTNSDHICDVQSEANDIIINSKDEMSINSAHTFDVQPEPSDNTVSLTHKPDISSTSG SDVPSGPGDITDSLGYDPDFNSTHTGHVQSESNNSPKHKLPINSAHTYDVQSGPSDITDGHRFESEFNSTHICDVQSGPS DMSVNSKRKSSIDSAQIDDAQSDPSDISIGSKQEYSINSAQIDNVQSEPSDISIGSKQESSINSAQIDNVQSEPSNISIS SKQETSINSTQIDDVQSEPSDISISSKNKLRINSAQIDDVQSAPSGISVSSEQETSIISAQVDDVQSEYSDISISSKHEP SINSTQTDDIQSEPIDISFGSKQESCINSAQMYDVQSEPSDISISSTQETSINSAQMYDVQLEPSDISISFKDKPSINSS QVDDVQSEPSDICFGSEQETCINSAQIYDVQSEPSNISFSSKQETSINSTQMYDVQSEPSDISISSNQETSINSTQMYDV QSEPSDISISSNQETSINSTQMYDVQSEPSDISISSNQETSINSTQMHDVQSEPSDISISSNQETTINSTQMYDVQSDPS DISISSKHKPSINSARMYDVQSEPSDISISSKHNPSIDSTQMFDVQSEPSDFSISSKHKPSIDSTQIYDVQSAPSGLTIS YKQKTSINSAQMYEVQSEPSDFSVSSKRKPSIDSIHMYDDVQLKSSNFMVSRTPEPTYKIIPEPSSSVSVNVSGLSSVLA SVSQGSVQHIFQRTLSPAEVLHVHSYAK---------GDYSDIEPRIQHER-DSDSD----------------------- -SESQDDNKKEAERP---------------AEAQYRLPRLPR--HHPLIKDSISDEE-LQDQAASEED---------GLD GEAWARPLTQL---WQNRPYN-------------------------PDREREYNREMGLRPPYCSICMLFQAHHR----- -------SEGAES-EPAVVLR-GGQMRTKPLIPERCFTITTEES---ADVQPSTAHLEEDGTSLLISCSLCSVRVHTSCY GVASG---------RVSKDWKCARCK----ANAFAESCCLCSLRGGALHR-ANNG------------------------- -----------------------KWVHVLCAVA----------VQEARFVNITERSPVDLSGIPLQRFK----------- ---------LKCYYCKRR-MK-KTLGCCVQCSHGR-CPTSYHPTCAQAAGVIMHPDDWPFVVYVTCCRHK-----GPVQS ERNKSAMR-ELSVGQRVICKHKNGRYYQCEVIQLTK--------------ETFYEVNFDDGS----------------FS DNLFPEDIVN-RDCAQLGPPPQGEVVQVRWTDGLVYGAKFVAA--------HVIQMYQVEFEDG-SLLTAKRDDVYTLDE ELPKRVKSRLS--KASDMRFDGMFGEK-KVQES-KRQRVINSRYRGDYIEPVIYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Takifugu_rubripes_KDM4A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MTTDTPSQS-------------------------------------------------------VGSRVMTFTPSKEEFK DFNQYIAYMESQGAHRAG-------------------------------------------------------------- ---------MARVI------------------------------------------------------------------ -------------------PPKGWKPRK-------------------------------------TYDD----------- ------------------------------------------------------------IDDLVIPAPIQQVVTGQS-- -----------GLFTQYNIQKKPMTVKEFRKTSNMD---KFCNPRYAD-FDELERKFWKNLT---FNPPLYG-ADVSGTL Y-----------------DADVTEWNIGHLKTILDTVENESGIKIKGVNTPYLYFGMWKSAFAWHTEDMDLYSINFLHFG EPKSWY---IVPPEHGKRLERLAKGFFPGN---AQSCEAFLRHKMTLISPSILKK-YSIPFEKVTQEAGQ-FIVTFPFGY HAGFN-HGFNCAESTNFATQRWIDYGKQATL--CSCRQDMVKISMDVFVLKYQPDRYKLWKAGKDNTAIDHSKPTPEAAK FLQDN-------------KSQS-----PAEDEPE--------------VTSSTQEEPCFHPP---LPCFSSKPQAGTK-- -----------------------------RQLDAIKVCEEVKVDPTMNSS-----------------------TEVEPKR AKVSTQE---------SPSKPPD--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------KPDTDI-------------------------------- -------------------------------------------------------------------------------- ---------ETAARFCY----------------------------------------------------VHLGLL--LLF LDK---RNVLPEPKTEKRTKLEPKPQ------------------------------------------------------ ----PKVSSRKTTNSPSKK----------------------------------------------DKNSSTSTCETREAA ERRV---------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------ASEEATSPDKCQ---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------PSSRFN----------- -------------------VLHVHSYAK---------GDYGE--GEIQSKE-DRSERRVFRELALIH------------- TSSLQQG-AEEATTD---------------KEAEGDLGQLPG--HHPLIKDGMSDEETPQEPSIAEEG---------CLD GESWAKPLAHL---WQDKPAN-------------------------LKKEREYNQRMCSRPPYCSICTLFHTHQQ----- -------TKCRTTGESPVVVD-RGRMRTKPLIPEMCFATTTEEDSE-SEKPPATPYLEEDGTSLLISCSTCSIRVHSSCY GVDPA---------TVSKDWKCVRCK----ANAMTENCCLCSLRGGALQK-ANNN------------------------- -----------------------KWVHVLCAVA----------VLEARFVNVTERSPVDLSGIPLQRFK----------- ---------LKCYYCKKR-MK-KASGCCVQCSHGR-CPTAYHPTCAQAAGVLMRPDEWPFVVHVTCCRHK-----SPTQI ERNKAAMN-ELTVGQKVICKHKNGRYYQCDVVQLSK--------------ETFYEVNFDDGS----------------FS DNLFPEDIVN-RDCAQLGPPPQGEVVQVRWTDGLVYGAKFVAA--------HAVHMYLVEFEDG-SQLTAKRDDVYTLDE ELPKRVKSRLS--KASDMRFDGIFEEREIIQDS-KRQRVINSRYRGDYIEPVIYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Tetraodon_nigroviridis_KDM4A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MTTDTPCPS-------------------------------------------------------VASRVMTFTPSKEEFK DFNQYIAYMEAQGAHRAG-------------------------------------------------------------- ---------MARVI------------------------------------------------------------------ -------------------PPKGWKPRK-------------------------------------SYDD----------- ------------------------------------------------------------IDDLVIPAPIQQVVTGQS-- -----------GLFTQYNIQKKPMTVKEFRKTSNMD---KFCNPRYAD-FDELERKFWKNLT---FNPPLYG-ADVSGTL Y-----------------DADVTEWNIGRLNTILDTVETESGIKIKGVNTPYLYFGMWKSAFAWHTEDMDLYSINFLHFG EPKSWY---IVPPEHGKRLERLAKGFFPGN---AQSCEAFLRHKMTLISPSILKK-YSIPFEKVTQEAGQ-FIVTFPFGY HAGFN-HGFNCAESTNFATQRWIDYGKQATL--CSCRQDMVKISMDVFVHKYQPERYKLWKAGKDNATIDHSKPTPEAAR FLTES-------------KSEPSKG--PAEDASE--------------VTGSAREE------------KSSKTSTGTK-- -----------------------------RQLEAIKACEDVKLEPMVNSS-----------------------SEMEPKR AKISAQG---------SPPQPPG--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GADRGT-------------------------------- -------------------------------------------------------------------------------- ---------SGVASKRL----------------------------------------------------QGTGLL--FPS SEP---GNVLPEPKKEKPAKLETKAQ------------------------------------------------------ ----LKASLRKTSNSFSKK----------------------------------------------DKSSAAPACEP---- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------SEEVSSPDRCQ---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------PASRCSHEHK------- ---------LFQRTLSPADVLHVHSYAK---------GDYGE--GELQSKE-EKSES---SEIKAER------------- DKRLGRSQVAEALTD---------------QEPEGDLGQLPG--HHPLIKDGMSDEETPQEPSIAEEG---------CLE GEGWAKPLAHL---WQDKPAN-------------------------LKKEREYNQRMCSKPPYCSICTLFHTHQQVET-- --SSAARTKCRNSMESPVIMA-GGGMRTKPLIPEMCFATTTEEDSE-SEKPPATPYLEEDGTSLLVSCSNCSIRVHTSCY GVDPA---------TVSKDWKCARCK----ANAMTENCCLCSLRGGALQK-ANNN------------------------- -----------------------KWVHVLCAVA----------VLEARFVNITERSPVDLSGIPLQRFK----------- ---------LKCYYCKKR-MK-KASGCCVQCSHGR-CPTAYHPTCAQAAGVLMQPDEWPFVVHVTCCRHK-----SPAQI ERNKAAMN-ELVVGQKVICKHKNGRYYQCDVVQLSK--------------ETFYEVNFDDGS----------------FS DNLFPEDIVS-RDCAQLGPPPQGEVVQVRWTDGLVYGAKFVAA--------RAVHMYLVEFEDG-SQLTAKRDDVYTLDE ELPKRVKSRLS--KASDMRFDGIFEEKEIIQDS-KRQRVINSRYRGDYIEPVIYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Gasterosteus_aculeatus_KDM4A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MASGVISQNN------------------------------------------------------GSKGIMTFYPTPEEFK NFSRYIAYVESQGAHKAG-------------------------------------------------------------- ---------LAKIV------------------------------------------------------------------ -------------------PPKEWKPRS-------------------------------------SYDD----------- ------------------------------------------------------------IDDLVIPAPIQQVVTGQS-- -----------GLFTQYNIQKKSMTVREFRKIANSD---KFCSPHYDD-FEELERKYWKNVT---FNPPIYG-ADVNGSL Y-----------------DPDVKDWNICHLDTILDTVEHESGITIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFG EPKSWY---CVPPEHGKRLERLAKGFFPGS---SQNCEAFLRHKMTLISPSILKK-YGIPFEKITQEAGE-FMVTFPYAY HAGFN-HGFNCAESTNFATERWIEYGKQAVL--CSCRRDMVKISMDVFVKKFQPDRYEQWLAGRDVLPIDHRRPTPEAKE FLGESS------------NDTATCGDDGERKREP--------------ADAASLGTPRSALN---------TQRIETK-- -----------------------------RHRVCLEVPDEVVPKDEDEDG-----------------------AEQYGKR PRLILIP-----------PRTTA--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------QDGKRN-------------------------------- -------------------------------------------------------------------------------- ---------KG----II----------------------------------------------------TFCNYTYISCL PK------------IDFLSLIKTRAP------------------------------------------------------ ---AISSQSQPGNRYLSVS----------------------------------------------ATPSWTEATAQP--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------ARKMGVASLLFH--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------KTLSS-------------- -----------------KDALQVQSYTM---------EKQQQQHSHTQLQV-HSYARAEGLVEPGRK------------- EDKPKATSPAEAQAEQVSEEQSYCMSVVEKQQPQAQLCTLPR--HHPLIREAHSDNEEFMDEEFEQE------------E KEEWAKPLTQL---WQCRPYN-------------------------PEVEREYNKSLGQQAPYCSICLLFYTYHQ----- -----SESSSGSSSVTLVNRP-GGRQWSKPLIPEMCFNTQSSRSNDNGEGQLSNPHVAEDGTSRLVSCAQCCVRVHTSCY GVPEDE--------GELDDWLCTRCE----ADATTEDCCLCSLRGGALQR-ANND------------------------- -----------------------KWVHVLCAIT----------VLEARFVSVTERGPVDLSAIPLPRFK----------- ---------LKCAYCRKR-MKREVKGCCVQCSHGR-CSTAFHPTCAQAAGMIMNPDDWPFTVFITCHRHK-----APGIP ERNKASMR-ELAVGQRVICKHKNGRYYHSEVVELTT--------------ATFYEVVFDDGS----------------YS NNLFPEDIQN-RDCVRLGPPTEGDAVQVRWTDGLIYGAKFLVS--------HSIPMYLVEFEDG-SQITVKREDIYTLDE NLPKRVKSRMS--VASDMRFE-LFSQSNVKQNS-KRQRVINSRYREDYIEPVIYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Gasterosteus_aculeatus_KDM4A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MTTDTPAQS-------------------------------------------------------VGSRIMTFTPTKEEFK DFSRYIAYMESQGAHKAG-------------------------------------------------------------- ---------MSKVI------------------------------------------------------------------ -------------------PPKDWKPRQ-------------------------------------TYND----------- ------------------------------------------------------------IDDLVIPAPIQQVVTGQS-- -----------GLFTQYNIQKKPMTVLEFRKTSNMD---KFCSPRYVD-FDELERKFWKNLT---FNPPLYG-ADVSGTL Y-----------------DPDVTEWNIGRLNTILDTVENESGIKIKGVNTPYLYFGMWKSAFAWHTEDMDLYSINYLHFG EPKTWYSRYVVPPEHGKRLERLAKGFFPGN---AQGCEAFLRHKMTLISPSILKK-FGIPFEKVTQEAGQ-FVVTFPFAY HAGFN-HGFNCAESTNFATQRWIDYGKQATL--CSCRQDMVKISMDVFVRKFQPDRYKLWKAGKDNAAIDHSKVPPEAAE LPREE-------------KSEPPK---EAESKEP--------------ATPAPEDKSKNPPL---KRLLNPKPQTGTK-- -----------------------------RQLQATEASGDIGVELPVKENE---------------------IEGVEPKK ARLSRKD---------SPTKVK---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------PDKGT-------------------------------- -------------------------------------------------------------------------------- ---------VQSVKLLL----------------------------------------------------PRWGLKGRLGY LEVGCIGNFTTHSTGEAAKRYCTINN------------------------------------------------------ ----KPSLAGRPEGSQAKS----------------------------------------------PSKSSSKKTSSRQ-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------SASNTSPAHKL---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------FQTTMS----------- ----------------PADVLHVHSYAK---------GDYKAVGGDTHTHK-CRSST---VAIVEPV------------- TEGVSLQQVAEESAG---------------EEDLSDLGQLPG--HHPLIKDCLSDEEAPEEAPPAEEG---------GLE GESWAKPLAHL---WQNRPPN-------------------------LKKERVYNQCMGSKAPYCSICTLFHTYQQ----- -------TECASSVDSPVMLA-GGRMRTKPLIPEMCFTTTTEEDSE-CDEQPVTPHLEEDGTSLLISCSQCSIRVHTSCY GVDPA---------SVSKEWKCVRCK----ANAMNENCCLCLLRGGALQK-ANNN------------------------- -----------------------KWVHVLCAVA----------VLEARFVNITERSPVDLSGIPLQRFK----------- ---------LKCYYCKKR-MK-KASGCCVQCSHGR-CPTAYHPTCAQAAGVLMQPDEWPFVVHVTCCRHK-----GPTQI ERNKAAMH-ELTVGQKVICKHKNGRYYQCDVVQLSK--------------ETFYEVNFDDGS----------------FS DNLFPEDIVS-RDCAQLGPPPKGDVVQVRWTDSLVYGAKFVAA--------HAIHMYLVEFEDG-SQLTAKRDDVYALDE ELPKRVKSRLS--KASDMRFDGIFEGKEIIKQS-KRQRVINSRYRGDYIEPVIYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Oryzias_latipes_KDM4A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MTTDPPVQS-------------------------------------------------------EAFRVMTFTPSKEEFK DFVRYVAYMESQGAHRAG-------------------------------------------------------------- ---------IAKVI------------------------------------------------------------------ -------------------PPKGWKPRR-------------------------------------TYDD----------- ------------------------------------------------------------VDDLLIPAPIQQVVTGQS-- -----------GLFTQYNIQKKPMLVHEFQKTSNLD---KFCSPRFVD-FNELEKKFWKNLT---FNPPLYG-ADISGTL F-----------------DPDVPDWNISHLDSILNALEGKCDDKIKAAQGPLIDFGMWKSAFAWHTEEMDLYRLSYMHYG EPRSWY---VVPPEHGRRLEKLAKGFFPGN---AQNCEAFLRHKMTLISPTILKK-YNIPFEKVIQEAGQ-FIVTFPFAY HAGFN-HGFNCAESTNFATERWIEYGKRATL--CSCRQDSVKISMDAFVHKYQPERYSLWKAGKDHVLIDHSKPTPEAAE FQRKA-------------DVQPLKESLSKRSAKE--------------PSGRIQYNSGDEPPGGEVSRLTAAPPQKKR-- -----------------------------THKIPLAAASEINTITTYYSS----------------------LTKNSNKV TECPPPN---------KPLKSEH--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------RTSREN-------------------------------- -------------------------------------------------------------------------------- ---------VVDQSDEP----------------------------------------------------FYSQLTEKKTE GAESDKSDLMDEDSDTEAAELEATKE------------------------------------------------------ ----KGSKQQLQSKVQSKS----------------------------------------------SSKKGVNRRSPAK-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------KEKNGETATDV---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------SPHRPP----------- ----------------ATKLVSPNSKET---------GHSMDSPGETQLSP-AGLFQ------RPLS------------- SADVLHVMEVSMTGD---------------QEPEKVQVQLPN--HEPPPQDCTSDEEGADELSTSEEF---------GLE VENWAKALAHL---WQNRPTN-------------------------LKKEKEYNQRMGCKPPYCSICALFHTYQQVHF-- --CT--VSMEYKRANAPVMGA-GGHMRTKPLIPEMCFITTTEEDSE-QQEESVAPYLEEDGSSLLISCSQCCVRVHTSCY GVDPT---------TVTKEWKCARCK----ANAMTEDCCLCWLRGGALQR-TSNH------------------------- -----------------------KWVHVLCAVA----------VLEARFVSISDRSPVDLSGIPLQRFK----------- ---------LKCYYCKKR-MK-KASGCCVQCSHGR-CPTAYHPTCAQAGGVLMQPGEWPFVVHVTCCRHK-----GPAQI ERNKAAMH-ELSVGQKVICKHKNGRYYQCDVVQLSK--------------ETFYEVNFDDGS----------------FS DNLFPEDIVS-RDCAQLGPPPSGEVVQVRWTDGLVYGAKFVAA--------HITQMYLVEFEDG-SQLTAKRDDVYTLDE ELPKRVKSRLS--KASDMRFDGIFEEKEIIRES-KRQRVINSRYRGDYIEPVIYRAIME--------------------- -------------------------------------------------------------------------------- ------------------------------------- >Homo_sapiens_KDM4B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MGSEDHGAQNPS------------------------------------------------------CKIMTFRPTMEEFK DFNKYVAYIESQGAHRAG-------------------------------------------------------------- ---------LAKII------------------------------------------------------------------ -------------------PPKEWKPRQ-------------------------------------TYDD----------- ------------------------------------------------------------IDDVVIPAPIQQVVTGQS-- -----------GLFTQYNIQKKAMTVGEYRRLANSE---KYCTPRHQD-FDDLERKYWKNLT---FVSPIYG-ADISGSL Y-----------------DDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFG EPKSWY---AIPPEHGKRLERLAIGFFPGS---SQGCDAFLRHKMTLISPIILKK-YGIPFSRITQEAGE-FMITFPYGY HAGFN-HGFNCAESTNFATLRWIDYGKVAT--QCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSP ELSSWSA-----------------------------------------SRASLKAKLLRRQISLKENRHWRKTEEERKPS LERK---------------KEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEG--------------------TAGAALLEE AGGSVKEEAGPEVDPEEEEEEPQ--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------PLP-HGREAEGAE------------------------------- ----------------------------------------------------------------------------EDGR GKLRPTKAKSERKKKSFGLLPP---------------------------------QLPPPPAHFPSEEALWLPSPLEPPV LGPG----PAAMEESPLPAPLNVVPPEVPS-------------------------------------------------- ---EELEAKPRPIIPMLYV------------------------------------------------VPRPGKAAFN--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------QEHVSCQQAFEHFA------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------QKGPTWKEPVSPM-----------ELTGPEDGAASSGAGRMETKARAG---------------- -EGQAPSTFSKLKM-------------EIKKSRRHPLGRPP-TRSPLSVVKQEASSDEEASPFSGEED---------VSD PDALRPLLSLQ---WKNRAAS-------------------------FQAERKFNAAAARTEPYCAICTLFYPYCQALQ-- -TEKEAPIASLGEGCPATLPS-KSRQKTRPLIPEMCFTSGGEN----TEPLPANSYIGDDGTSPLIACGKCCLQVHASCY GIRPE---------LVNEGWTCSRCA----AHAWTAECCLCNLRGGALQMTTDRR------------------------- ------------------------WIHVICAIA----------VPEARFLNVIERHPVDISAIPEQRWK----------- ---------LKCVYCRKR--MKKVSGACIQCSYEH-CSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHK--------SG GHAVQLLR-AVSLGQVVITKNRNGLYYRCRVIGAAS--------------QTCYEVNFDDGS----------------YS DNLYPESITS-RDCVQLGPPSEGELVELRWTDGNLYKAKFISS--------VTSHIYQVEFEDG-SQLTVKRGDIFTLEE ELPKRVRSRL--SLSTGAPQEPAFSGEEAKAAKRPRVGTP--LATEDSGRSQDYVAFVESLLQVQGRPGAPF-------- -------------------------------------------------------------------------------- ------------------------------------- >Pan_troglodytes_KDM4B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MGSEDHGAQNPS------------------------------------------------------CKIMTFRPTMEEFK DFNKYVAYIESQGAHRAG-------------------------------------------------------------- ---------LAKII------------------------------------------------------------------ -------------------PPKEWKPRQ-------------------------------------TYDD----------- ------------------------------------------------------------IDDVVIPAPIQQVVTGQS-- -----------GLFTQYNIQKKAMTVGEYRRLANSE---KYCTPRHQD-FDDLERKYWKNLT---FVSPIYG-ADISGSL Y-----------------DDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFG EPKSWY---AIPPEHGKRLERLAIGFFPGS---SQGCDAFLRHKMTLISPIILKK-YGIPFSRITQEAGE-FMITFPYGY HAGFN-HGFNCAESTNFATLRWIDYGKVAT--QCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSP ELSSWSA-----------------------------------------SRASLKAKLLRRQISLKENRHWRKTEEERKPS LERK---------------KEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEG--------------------TAGAALLEE AGGSVKEEAGPEVDPEEEEEEPQ--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------PLP-HGREAEGAE------------------------------- ----------------------------------------------------------------------------EDGR GKLRPTKAKSERKKKSFGLLPP---------------------------------QLPPPPAHFPSEEALWLPSPLEPPV LGPG----PAATEESPLPAPLNVVPPEVPS-------------------------------------------------- ---EELEAKPRPIIPMLYV------------------------------------------------VPRPGKAAFN--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------QEHVSCQQAFEHFA------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------QKGPTWKEPVSPM-----------ELTGPEDGAASSGAGRMETKARAG---------------- -EGQAPSTFSKLKM-------------EIKKSRRHPLGRPP-TRSPLSVVKQEASSDEEASPFSGEED---------VSD PDALRPLLSLQ---WKNRAAS-------------------------FQAERKFNAAAARTEPYCAICTLFYPYCQALQ-- -TEKEAPTASLGEGCSATLPS-KSRQKTRPLIPEMCFTSGGEN----TEPLPANSYIGDDGTSPLIACGKCCLQVHASCY GIRPE---------LVNEGWTCSRCT----AHAWTAECCLCNLRGGALQMTTDRR------------------------- ------------------------WIHVICAIA----------VPEARFLNVIERHPVDISAIPEQRWK----------- ---------LKCVYCRKR--MKKVSGACIQCSYEH-CSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHK--------SG GHAVQLLR-AVSLGQVVITKNRNGLYYRCRVIGAAS--------------QTCYEVNFDDGS----------------YS DNLYPESITS-RDCVRLGPPSEGELVELRWTDGNLYKAKFISS--------VTSHIYQVEFEDG-SQLTVKRGDIFTLEE ELPKRVRSRL--SLSTGAPQEPAFSGEEAKAAKRPRVGTP--LATEDSGRSQDYVAFVESLLQAQGRPGAPF-------- -------------------------------------------------------------------------------- -------------------------------------