>Homo_sapiens_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MAEANNPSEQELESEPRSWSLLEQLGLAG-ADLAAPGVQQQLELERERLRRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSS------------------ ------------------------------------RRLDLLHQQLQELHAHVVLPDPA---------------ATHDGP QSPG------------------AGGPTCSATNLSRVAGLEKQLAIELKVKQGAEN---------------------MIQT YSNGS------------TKDRKLLLTAQQMLQDSKTKIDIIRMQLRRAL---QAGQL-------ENQAAPDDTQG----- -------SPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDR------------------------------ -----------------KAVSEAQEKLTESNQKLGLLREALERRLGELP------ADHPKGRLLREELAAASS------- --AAFSTRLAGPFPATHYSTLC-----KPAPLTG-TLEVRVVGCRDLPE-------TIP-WNPTPSMGGPGTPDSRPP-- FLSRPARGLYSR---SGSLSGRSSLKAEAENT-----------SEVSTVLKLDNTVVGQTSW-KPCGPNAWDQSFTLE-- LERARELELAVFWRD--QRGLCALKFLKLEDFLDN-ERHEVQLDMEPQGCLVAEVTFRNPVIERI-PRLRRQKKIFS-KQ QGKAFQRARQMNIDVATWVRLLRRLIPNATG------TGTFSPGASP---------------GSEARTT----------- ------------------GDISVEKLNLGTDSDSSP-----------------QKSSRDPPS------------------ -------------------------------SPSSLS------------------------------------------- ----------------------------------------------------------------------------SPIQ ES-TAPELPS---------------------------------------------------------------------- --------------------ETQETPGPALCS------------------------------------------------ ----------------------------------------------------PLRKSPLTLEDFKFLAVLGRGHFGKVLL SEFRPSGELFAIKALKKGDIVARDEVE---SLMCEKRILAAVT-SAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAI-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSSERDAEDVKKQPFFR--TLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA AEQAAFLDFDFVAGGC----------- >Pan_troglodytes_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------MASDAVQSEPRSWSLLEQLGLAG-ADLAAPGVQQQLELERERLRRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSS------------------ ------------------------------------RRLDLLHQQLQELHAHVVLPDPA---------------AAHDGP QSPG------------------AGGPTCSATNLSRVAGLEKQLAIELKVKQGAEN---------------------MIQT YSNGS------------TKDRKLLLTAQQMLQDSKTKIDIIRMQLRRAL---QAGQL-------ENQAAPDDTQG----- -------SPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDR------------------------------ -----------------KAVTEAQEKLTESNQKLGLLREALERRLGELP------ADHPKGRLLREELAAASS------- --AAFSTRLAGPFPATHYSTLC-----KPAPLTG-TLEVRVVGCRDLPE-------TIP-WNPTPSMGGPGTPDSRPP-- FLSRPARGLYSR---SGSLSGRSSLKAEAENT-----------SEVSTVLKLDNTVVGQTSW-KPCGPNAWDQSFTLE-- LERARELELAVFWRD--QRGLCALKFLKLEDFLDN-ERHEVQLDMEPQGCLVAEVTFRNPVIERI-PRLRRQKKIFS-KQ QGKAFQRARQMNIDVATWVRLLRRLIPNATG------TGTFSPGASP---------------GSEARTT----------- ------------------GDISVEKLNLGTDSDSSP-----------------QKSSRDPPS------------------ -------------------------------SPSSLS------------------------------------------- ----------------------------------------------------------------------------SPLQ ES-TAPELPS---------------------------------------------------------------------- --------------------ETRETPGPALCS------------------------------------------------ ----------------------------------------------------RLRKS-LTLEDFKFLAVLGRGHFGKVLL SEFRPSGELFAIKALKKGDIVARDEVE---SLMCEKRILAAVT-SAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAI-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSSERDAEDVKKQPFFR--TLGWEALLARRLPPPFVPTVSGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA AEQAAFLDFDFVAGGC----------- >Pongo_abelii_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------MASDAVQSEPHSWSLLEQLGLAG-ADLAAPGVQQQLELERERLRRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSS------------------ ------------------------------------RRLDLLHQQLQELHAHVVLPDPA---------------ATHDGP QSPG------------------AGGPTCSATNLSRVAGLEKQLAIELKVKQGAEN---------------------MIQT YSNGS------------TKDRKLLLTAQQMLQDSKTKIDIIRMQLRRAL---QAGQL-------ENQAAPDETQG----- -------SPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDR------------------------------ -----------------KAVSEAQEKLTESNQKLGLLREALERRLGELP------ADHPKGRLLREELAAASS------- --AAFSARLAGPFPATHYSTLC-----KPAPLTG-TLEVRVVGCRDLPE-------TIP-WNPTPPVGGPGTPDSRPP-- FLSRPARGLYSR---SGSLSGRSSLKAEAENT-----------SEVSTVLKLDNTVVGQTSW-KPCGPNAWDQSFTLE-- LERARELELAVFWRD--QRGLCALKFLKLEDFLDN-ERHEVQLDMEPQGCLVAEVTFRNPVIERI-PRLQRQKKIFS-KQ QGKAFQRARQMNIDVATWVRLLRRLIPNATA------TGTFSPGASP---------------GSEARTT----------- ------------------GDISVEKLNLGTDSDSSP-----------------QKSSRDPPS------------------ -------------------------------SPSSLS------------------------------------------- ----------------------------------------------------------------------------SPIQ ESSTTPELPS---------------------------------------------------------------------- --------------------ETQETPGPALCS------------------------------------------------ ----------------------------------------------------PLRKSPLTLEDFKFLAVLGRGHFGKVLL SEFRPSGELFAIKALKKGDIVARDEVE---SLMCEKRILAAVT-SAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAV-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSSERDAEDVKKQPFFR--TLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA GEQAAFLDFDFVAGGC----------- >Macaca_mulatta_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MAEASTPSEQELESEPRSWSLLEQLGLAG-ADLAAPGVQQQLELERERLRRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSS------------------ ------------------------------------RRLDLLHQQLQELHAHVVLPDPA---------------ATHDGP QSPG------------------AGGPTCSATNLSRVAGLEKQLAIELKVKQGAEN---------------------MIQT YSNGS------------TKDRKLLLTAQQMLQDSKTKIDIIRMQLRRAL---QAGQL-------ENQAAPDETQG----- -------DPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDR------------------------------ -----------------KAVSEAQEKLTESNQKLGLLREALERRLGELP------ADHPKGRLLREELAAASS------- --AAFSARLAGPFPATHYSTLC-----KPAPLTG-TLEVRVVGCRDLPE-------TIP-WNPTPSGGGPGTPDSRPP-- FLSRPARGLYSR---SGSLSGRSSLKADAENT-----------MQCSLYLKIQ---LGRARWLKPVIPALWEA----E-- TGGSRGQEIETILAN--TRGLCALKFLKLEDFLDN-ERHEVQLDMEPQGCLVAEVTFRNPVIERI-PRLRRQKK-FS-KQ QGKAFQRARQMNIDVATWVRLLRRLIPNATG------TGTFSPGASP---------------GSEARTT----------- ------------------GDISVEKLNLGTDSDGSP-----------------QKSSRDPPS------------------ -------------------------------RLSSLS------------------------------------------- ----------------------------------------------------------------------------SPIQ ESSITPKLPS---------------------------------------------------------------------- --------------------ETQETPGPALCS------------------------------------------------ ----------------------------------------------------PLRKSPLTLEDFKFLAVLGRGHFGKVLL SEFRPSGELFAIKALKKGDIVARDEVE---SLMCEKRILAAVT-NAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAV-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTEGYVKITDFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSSERDAEDVKKQPFFR--TLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA AEQAAFLDFDFVAGGC----------- >Mus_musculus_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MAADPPLDSELESEPRSWSLLEQLGLAG-ADLAAPGVQQQLELERERLKRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRSLAPVELLLRGSA------------------ ------------------------------------RRLDLLHQQLQELHAHVVLPDPA---------------AGSDAT QSLA------------------EGSPICSSTNLSRVAGLEKQLAIELKVKQGAEN---------------------MIQT YSNGS------------SKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQALQAGEL-------ESQAAPDEAQG----- -------DPELGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSGAKAPDR------------------------------ -----------------KAVSEAQEKLTESNQKLGLLRESLERRLGELP------ADHPKGRLLREELTAASS------- --SAFSAILPGPFPATHYSTLS-----KPAPLTG-TLEVRVVGCKNLPE-------TIP-WSPPPSVGASGTPESRTP-- FLSRPARGLYSR---SGSLSGRSSLRGEAENA-----------TEVSTVLKLDNTVVGQTAW-KPCGPNAWDQSFTLE-- LERARELELAVFWRD--QRGLCALKFLKLEDFLDN-ERHEVQLDMEPQGCLVAEVTFRNPIIERI-PRLQRQKKIFS-KQ QGKAFQRARQMNIDVATWVRLLRRLIPSAVA------TGTFSPNASP---------------GAEIRHT----------- ------------------GDISMEKLNLGADSDSSS-----------------QKSPPGLPS------------------ -------------------------------TSCSLS------------------------------------------- ----------------------------------------------------------------------------SPTH ESTTSPELPS---------------------------------------------------------------------- --------------------ETQETPGPGLCS------------------------------------------------ ----------------------------------------------------PLRKSPLTLEDFKFLAVLGRGHFGKVLL SEFRSSGELFAIKALKKGDIVARDEVE---SLMCEKRILAAVT-RAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAV-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSTERDAEDVKKQPFFR--SLGWDVLLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA AEQAAFRDFDFVAGGY----------- >Rattus_norvegicus_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MAGD-----AVQSEPRSWSLLEQLGLAG-ADLAAPGVQQQLELERERLKRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRSLAPVELLLRGSA------------------ ------------------------------------RRLDLLHQQLQELHAHVVLPDPT---------------AGSDAP QSLA------------------EGSPVCSSTNLSRVAGLEKQLAIELKVKQGAEN---------------------MIQT YSNGS------------TKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQALQAGQL-------ESQAAPDEAHG----- -------DPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDR------------------------------ -----------------KAVSEAQEKLTESNQKLGLLRESLERRLGELP------ADHPKGRLLREELTAASS------- --AAFSAILPGPFPATHYSTLS-----KPAPLTG-TLEVRVVGCKNLPE-------TIP-WSPPPSVGASGTPDSRTP-- FLSRPARGLYNR---SGSLSGRSSLKGEAENS-----------TEVSTVLKLDNTVVGQTAW-KPCGPNAWDQSFTLE-- LERARELELAVFWRD--QRGLCALKFLKLEDFLDN-ERHEVQLDMEPQGCLVAEVTFRNPIIERI-PRLQRQKKIFS-KQ QGQTFQRARQMNIDVATWVRLLRRLIPNAVA------TGSFSPNASP---------------GSEIRST----------- ------------------GDISMEKLNLGADSDSSS-----------------QKSPAGLPS------------------ -------------------------------TSCSLS------------------------------------------- ----------------------------------------------------------------------------SPTH ESTTSPELPS---------------------------------------------------------------------- --------------------ETQETPGPGLCS------------------------------------------------ ----------------------------------------------------PLRKSPLTLEDFKFLAVLGRGHFGKVLL SEFHSSGELFAIKALKKGDIVARDEVE---SLMCEKRILATVT-RAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAV-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSTERDAEDVKKQPFFR--TLDWDALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA AEQAAFRDFDFVAGGY----------- >Canis_familiaris_PKN1 --------------------------------------------------------MLGFEPRSAQSPSAGNGGSFPGDS SLQRRGRGGGGESLLFSEGSREARRPLPRPALTWLSLSFGFPRAQLGHPGAERGAAPGTRGSSRQGGRGRRPAEPRRRDP QPRGPPGAAPPPPRPLPGRRPRRSRDPARRPLGPEGAARGRGGLARRGRSGRSRPERAARRRGLRRARPFPAPRGAHARS SRRPSLRAGTPGGRREDMASDAVQSEPRSWSLLEQLGLAG-ADLAAPGVQQQLELERERLRRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSS------------------ ------------------------------------RRLDLLHQQLQELHAHVVLPDPA-A-------------AARDAP LSPG------------------ASGQACSATNLSRVAGLEKQLAIELKVKQGAEN---------------------MIQT YSNGS------------TKDRKLLLTAQQMLQDSKTKIDIIRMQLRRAL---QAGQL-------ESQAAPDEAQG----- -------SPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDR------------------------------ -----------------KAVSEAQEKLTESNQKLGLLREALERRLGELP------ADHPKGRLLREELAAASS------- --AAFSARLAGPFPPTPYSTLC-----KPAPLTG-TLEVRVVGCKDLPE-------TIP-WSSSPVAGVPGTPDSRTT-- FLSRPARGLYSR---SGSLSGRSSLKVEAENT-----------SEVSTVLKLDNTVVGQTSW-KPCGPSAWDQSFTLE-- LERARELELAVFWRD--QRGLCALKFLKLEDFLDN-ERHEVQLDMEPQGCLVAEVTFRNPVIERI-PRLRRQKKIFS-KQ QGKAFQRARQMNIDVATWVRLLRRLIPNATA------TSTFSPGASP---------------GPEVRST----------- ------------------GDISVEKLNLGTALDSLP-----------------QKSPLGPPS------------------ -------------------------------SPSSLS------------------------------------------- ----------------------------------------------------------------------------SPIQ ETTTTPEPPS---------------------------------------------------------------------- --------------------ETQETPGPALSS------------------------------------------------ ----------------------------------------------------PLKKSPLTLEDFKFLAVLGRGHFGKVLL SEFRPSGELFAIKALKKGDIVARDEVE---SLMCEKRILAAVT-RAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAV-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSSERDAEDVKKQPFYR--TLVWDSLLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA AEQAAFRDFDFVAGGC----------- >Felis_catus_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MEVRAIVTLSSPPPP-------------HLLDAP QSPG------------------AGSQACSATNLSRVAGLEKQLAIELKVKQGAEN---------------------MIQT YSNGS------------TKDRKLLLTAQQMLQDSKTKIDIIRMQLRR------AGQL-------ESQAAPDDAQG----- -------SADLGSVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDR------------------------------ -----------------KAVCEAQEKLTESNQKLGLLREALERRLGELP------ADHPKGRLLREELAVASS------- --AAFSARLAGPFPPTHYNTLC-----KPAPLTG-TLEVRVVGCRDLPE-------TVP-WSSSPSVGVPGTPDSRTT-- FLSRPARGLYSR---SGSLSGRGSLKVEAENT-----------SEVSTVLKLDNTVVGQTSW-KPCGPNAWDQSFTLE-- LERARELELAVFWRD--QRGLCALKFLKLEDFLDN-ERHEVQLDMEPQGCLVAEVTFRNPVIERI-PRLRRQKKIFS-KQ QGKTFQRARQMNIDVATWVRLLRRLIPNATA------TGTFSPGASP---------------GPEARST----------- ------------------GDVSMEKLNLGADLDSLP-----------------QKSPLGPPS------------------ -------------------------------SPSSLS------------------------------------------- ----------------------------------------------------------------------------SPIQ ETTTTPELPS---------------------------------------------------------------------- --------------------ETQETPGPALCS------------------------------------------------ ----------------------------------------------------PLRKSPLTLEDFKFLAVLGRGHFGKVLL SEFRPSGELFAIKALKKGDIVARDEVE---SLMCEKRILAAVT-RAAHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAV-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSSERDAEDVKKQPFFR--TLGWDTLLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA TEQAAFRDFDFVAGGC----------- >Bos_taurus_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------QSEPRSWSLLEQLGLAG-ADLAAPGVQQQLELERERLRRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRNLGPVELVLRGSS------------------ ------------------------------------RRLALLHQQLQELHAHVVLPDPA-V-------------GVHDAP QSPG------------------TGDSACSATNLSRVAGLEKQLAIELKVKQGAEN---------------------MIQT YSNGS------------TKDRKLLLTAQQMLQDSKTKIDIIRMQLHRAL---QACQL-------ESQAAPDEAQG----- -------SPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDR------------------------------ -----------------KAVSEAQEKLTESNQKLGLLREALERRLGELP------ADHPKGRLLREELAAASS------- --AAFSARLAGPFPATHYSTLS-----KPAPLTG-TLEVRVVGCRDLPE-------TIP-WNPSPSVGGPGTPDSRTP-- FLSRPARGLYSR---TGSLSGRSSLKAEAENT-----------NEVSTVLKLDNTVVGQTSW-KPCGPNAWDQSFTLE-- LERARELELAVFWRD--QRGLCALKFLKLEDFLDN-ERHEVQLDMEPQGCLVAEVTFRNPVIERI-PRLRRQKKIFS-KQ QGKAFQRARQMNIDVATWVRLLRRLIPNATA------TGTFSPGASP---------------GPEARST----------- ------------------GDISVEKLNLGTETDSSP-----------------QKSPLGPPS------------------ -------------------------------SPSSLS------------------------------------------- ----------------------------------------------------------------------------SPIQ ATTTTPELPS---------------------------------------------------------------------- --------------------ETQETPGPTLCS------------------------------------------------ ----------------------------------------------------PLRKSPLTLEDFKFLAVLGRGHFGKVLL SEFRPSGELFAIKALKKGDIVARDEVE---SLMCEKRILAAVT-NAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAV-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSSERDAEDVKKQPFFR--TLGWDALLARRLPPPFVPTLAGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA TEQAAFRDFDFVAGSC----------- >Loxodonta_africana_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------LQSESRNWSLLEQLGLAG-ADLAAPGVQQQLELERERLRRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRNLGPVELLLRGSS------------------ ------------------------------------RRLDLLHQQLQELHAHVVLPDPA---------------TAARG- -LQG------------------LPLPRCARTALAARPAREVQYHLHWPQRD---R---------------------LCHS NSESP------------NTDRKLLLTAQQMLQDSKTKIDIIRMQLRRAL---QAGQL-------ESHVAPDEAQG----- -------KAQMGAHEKNMEGIRKVTKPKRASRENAP-KTRLSHCGTGPGP------------------------------ -----------------ASPPQAQEKLTESNQKLGLLREALERRLGELP------ADHPKGRLLREELAAATS------- --SAFSVLLAGPFPATHYSTLC-----KPAPLTG-TLEVRVLGCRDLPE-------TIP-WSPSPSGGGPGASDSRTP-- FLSRPARGLYSR---SGSLSGRSSLKAEAENT-----------SEVSTVLKLDNTVVGQTSW-KPCGPNAWDQSFTLE-- LERARELELAVFWRD--QRGLCALKFLKLEDFLDN-ERHEVQLEMEPQGCLLAEVTFRNPVIERI-PRLRRQKKIFS-KQ QGKTFQRARQMNIDVATWVRLLRRFIPNGTT------TGTFSPGASP---------------GPEARSM----------- ------------------GDISVEKLNLGTNSDSSP-----------------QKSPLEPPS------------------ -------------------------------SPSSLS------------------------------------------- ----------------------------------------------------------------------------SQIQ EPPP-TSEPPP--------------------------------------------------------------------- --------------------ETQETPGPALCS------------------------------------------------ ----------------------------------------------------PLRKSPLTLKDFKFLAVLGRGHFGKVLL SEFQPSGELFAIKALKKGDIVARDEVE---SLMCEKRILAAVT-SVGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL--ML HIHSDVFSEPRAV-FYSACVVLGLQFLHEHKIVY---RDLKLDNLLLDTKG-SKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGEVSTLP--SLPHASLRPDMEPSCVQGWGLKSASTMCVACR-GQRRRPAS PSLLASGPQPSMLTPPPAQQ--TLGWDSLLARRLPPPFVPKLSGRTDVSNFDEEFTGEAPTLSPPRD-------ARPLTA TEQAAFQDFDFVAGGC----------- >Monodelphis_domestica_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------MASDALQSEPGTWSVLEQLGLAG-ADLAAPGVQQRLELEVERLRRE----------------- --------------------------IRKELKLKEGAENLRRATTDLGRSLGPVELLLRGST------------------ ------------------------------------RRLDLLHSQLQELHGLVVLHEPRQA-------------QPQLGQ AQDG------------------PQSPNCPATSLSLVAGLEKQLTIELKVKQGAEN---------------------MIHT YSNGN------------TKERKLLLTAQQMLQDSKTKIDIIRMQIRKAL---QAGQL-------ENQG-PEESHG----- -------GPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDR------------------------------ -----------------KAVSEAQAKLTESSQKLALLRAALELRLGELP------AEHPKGRLLLEELAMASS------- --STFSTRIG-PFPATHYSTLC-----KPSPLTG-TLSVRVLGCSGLPE-------TVP-WSSPPTSGSSGTSESRP--- FLGRPARGLYSR---SGSLSGRGSIKTEEP-T-----------NEVSAVLKVDNTVVGQTPW-KPCGPNAWDQSFTLE-- LERARELELSIFWRD--HRGLCALKFLKLEDFLDN-QRHQVQLELEPQGCLLAEVIFHNPVIERI-PRLQRQKKVFS-KQ QGKAFLRARQMNIDIATWVRLLRRLLPSPNS------TGTFSPGAT----------------TAEGRTS----------- ------------------GDIPIEKLNL--DSDSST-----------------QKSPLDLLS------------------ -------------------------------SPSSLSSPSS--------------------------------------- ---------------------------------------------------------------------------LSPRS QDTPQPSESTP--------------------------------------------------------------------- --------------------EDRETPGPTPSS------------------------------------------------ ----------------------------------------------------PLRTSPLSLNDFKFLAVLGRGHFGKVLL SEYLPSGELFAVKALKKGDIVARDEVE---SLMCEKRILGRGD-GRLPSLLGQPVRLLPDPRARVLRHGVRGGRGP--DA AHPSDVFTEPRAV-FYSACVVLGLQFLHDHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAIGIMRR--LLRRNPE RRLGSGERDAEDVKKQPFFR--TLGWEALLARQLPPPFIPVIKGRTDISNFDEEFTGEAPALTPPRE-------ARPLSA AEQEAFRDFDYVSKGC----------- >Anolis_carolinensis_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MANESLQ---------SDPGNWSVLEHLGLDQSSDFSDISVQQKLDEEKDKIKRE----------------- --------------------------IRKELKIKEGAENLRKATTDR-KNLSNVENLLKSSN------------------ ------------------------------------RKLETLHHQLQDLNAHIVVKDPEEL---------------AEAP QSPG------------------SLSR--STATQNRIAGLEKQLNIELKVKQGAEN---------------------MIQM YANGT------------AKDRKLLQTAQQMLQDSKTKINIIRMQIRKAM---------------QADEVQLNMEDGQ--- ------GNADLSAIELRIEELRHHFRVEHAVSEGAKNVLRLLGASKVQDR------------------------------ -----------------HAISEAQMKLNESSQKLDLLRHSLEQRLSELP------QDHPKGCIIKEELILDSS------- --PTFSVRNNTSYQHNQYNTLS-----KPSPLTG-TLEVQLLGCSGLLE-------FVPGRTRGSTVSLPCNSSFMSR-- S----GRGLYSR---SGSVSGRTTIKCEDIS------------NEVSAVLKLDNGVVGQTAW-KPIGLQAWNQTFTVE-- LERARELEIGVYWRD--YRSLCALKYLKLEDFLDN-QRHEIHLELEPQGTLLAEVTFFNPVIERI-PKLQRQKKIFS-KQ QGKAFLRARQMNIDIATWVRLLRRIIPTAST------TGTYSPSTQMNPAVGSE--------SRHSLNS----------- ------------------GDVAIEKLNLEGDRV---------------------EQMGQDDS------------------ -------------------------------ELPGKVLLG---------------------------------------- ---------------------------------------------------------------------------LQTGE EIPFQLELGPG--------------------------------------------------------------------- -------------------CEARGSESIFPS------------------------------------------------- ----------------------------------------------------HLRKTPLTMDDFRFVAVLGRGHFGKVLL SELHRTGNLFAIKALKKGDIIARDEVE---SLMCEKRIFEIVT-HAKHPFLVNLFACFQTPQHVCFVMEYTAGGDL--MM HIHTDVFTEPRAT-FYAACVVLGLQFLHDHKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGYADRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAIGIMRR--LLRRNPE RRLGSSERDAEDVKKQPFFR--SIEWEALLARKIKPPFVPVIKGREDISNFDEEFTAEAALLTPPRE-------SRPLTQ KEQDSFKDFDYVSNAC----------- >Danio_rerio_PKN1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MA SEEGRNTSLTEQHDDDTITQTETPSDPGGLSGLERLGLDHSSDYSDSSVQQRLDKERERIRRE----------------- --------------------------IRKELKIKEGAENLRRATTDK-RNAQQVDSQLRCSN------------------ ------------------------------------RRLDSLHAELQELDAHIVVKGTDDT--------------HDDAP QSPG------------------AESR--SSAHKERIAALERQLNIELKVKQGAEN---------------------MIPI YTNGS---------------------TKQMLQDSKTKIDIIRMQIRKAV---------------QAYEHNDDTQG----- -------KPDPCGMELRIEELRHHYRVEHAVAEGAKNVLRLLGAS----------------------------------- ---------------------KAQCRLSESSQRLDLLRDSLDRRLAELP------EDHPKASVIKEELVLASS------- --PAFSSQHSAPYLHNQYSTLS-----KPSPLTG-RLQVTLLGCMGLLE-------VVPGRSRGSQVVLPCYSPGEGR-- SFMRSGKGLYSR---SGSVSGKTPLKTDELS------------SDVSAVLKLDNTVVCQTAW-KMVGEQGWDQTFIIE-- LERSREMEIAVYWRD--YRSLCALKFLKLEDFLDN-QKHKVQLELEPQGLLLAEVTFFNPVIERV-PRLKRQKNVFS-KQ QGKAFLRARQMNVDIGTFVRLLRNAIPTVNN------TGTYSPNAH-------------------TLQT----------- ------------------GEISVEKLSLDFDSP----------------------MKVDIRR------------------ -------------------------------EVTDISTPE---------------------------------------- ---------------------------------------------------------------------------RQPST EPLSAPDVTT---------------------------------------------------------------------- ---------------------PIRTHSLSSK------------------------------------------------- -----------------------------------------------------QKKTSLSLQDFRLIAVLGRGHFGKVLL AEYKKSGSMYAIKALKKGDIVARDEVE---SLMCEKRIFEAVN-GAQHPFLVNLFACFQTPEHVCFVMEYTAGGDL--MM HIHADVFTEPRAV-FYSACVVLGLQFLHDNKIVY---RDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR--LLRRNPE RRLGSSEKDAEDVKKQPFFR--NMDWEALLLRKLPPPFIPSIGGKEDVSNFDEEFTTEAPTLTPPRE-------PRVLSR KDQDSFRDFDYVSDLC----------- >Takifugu_rubripes_PKN1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MSSAAEMGQFLFVVLESDPGGLSVLEQLGLDQNSDFSDSGVQQLLDEQREKIRRE----------------- --------------------------IRKELKIKEGAENLRRATTDK-RNAQQVDSQLRSSN------------------ ------------------------------------RRLENLHDQLQELDAHIVVKGGEEN--------------KEECP LSPG------------------TDRR--TSAHRDRIAALERQLNIELKVKQGVEN---------------------MIPI YSNGS------------TKDKKMLQTAQQMLQDSKTKIDIIRMQIRKAM---------------QANEQSDDTQG----- -------NQDVCGVELRIEELRHHYRVEHAVAEGAKNVLRLLSASKVQDK------------------------------ -----------------KALSEAQSRLSEASQRLDLLRDSLEQRLAELP------EDHPKASVIKEELVLASS------- --PAFSSRHGAPYLHNQYSTLN-----KPSPLTG-TLQVQLVGCVGLLE-------VVPGRSKGITVMLPCYCPGDTR-- SFMRGSKGLYGR---TGSVSGKTASKTDELS------------FEVSAVLKLDNTVVGQTVW-KTVGEQAWDQTFTVE-- LERSRELEIAVYWKD--YRSLCALKYVKLEDFLDN-QKHRVQLELEPQGLLLAEVTFFNPVIERV-PRLQRQKKVFS-KQ QGKAFLRARQMNVDIGTWVRLLRNAIPTVNN------SGTYSPNAHS-----------------LTLHP----------- ------------------GEVSVEKLSLDADSPIRGDYKRDMETHTPVRQA--QSGGVCVSI------------------ -------------------------------ILGRFKTVNNL-------------------------------------- ---------------------------------------------------------------------------EVPQT DSVCLFPLTSPVR------------------------------------------------------------------- ------------------NECPSLSPSLPQTSPQSA-------------------------------------------- ---------------------------------------LSEPHLLAVENPNKQKKGPLSLQDFRMIAVLGRGHFGKVLL SEYKKTGTMYAIKALKKGDIIARDEVE---SLMCEKRIFEIVN-MSHHPFLVNLLACFQTPEHVCFVMEYTAGGDL--MM HIHTDVFTEPRAV-FYSACVVLGLQFLHDHKIVY---RDLKLDNLLLDTDGYVKIADFGLCKEGMGFGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSNEAIGIIRREQLLRRNPE RRLGSGEKDAEEVKKQPFFR--TMDWEALLQRKVPPPFLPSITGKEDVSNFDEEFTAEAPTLTPPRE-------PRTLSR KDQESFRDFDYVSDLC----------- >Tetraodon_nigroviridis_PKN1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------EPDDAEK---------SDPGGLSVLEQLGLDQNSDFSDSGVQQLLDEQREKIRRE----------------- --------------------------IRKELKIKEGAENLRRATTDK-RNAQQVDSQLRSSN------------------ ------------------------------------RRLEDLHAQLQELDAHIVVKGGEEN--------------KEECP LSPG------------------TDSR--TSAHKDRIAALERQLNIELKVKQGVEN---------------------MIPV YSNGS------------TKDKKMLQTAQQMLQDSKTKIDIIRMQIRKAM---------------QANEQSDDTQASIP-- -DY-NHSNQDVCGVELRIEELRHHYRVEHAVAEGAKNVFRLLSASKVQDK------------------------------ -----------------KALSEAQSRLSEASQRLDLLRDSLEQRLAELP------EDHPKASVIKEELVLASS------- --PAFSSRHGAPYLHNQYSTLN-----KPSPLTG-TLQVQLVGCVGLLE-------AVPGRSKGTTVMLPCYSPGDTR-- SFMRGSKGLYGR---TGSVSGKTASKTDELS------------SEVSAVLKLDNTVVGQTVW-KTVGDQAWDQTFTVE-- LERSRELEIAVYWKD--YRSLCALKYVKLEDFLDN-QKHRVQLELEPQGLLLAEVTFFNPVIERV-PRLQRQKKVFS-KQ QGKAFLRARQMNVDIGTWVRLLRNAIPTVNN------SGTYSPNAHS-----------------VTLHP----------- ------------------GEVSVEKLSLDTDSP---------------------SGCVSLSS------------------ -------------------------------HIPRQE------------------------------------------- ---------------------------------------------------------------------------RMPVI EPFSPPDLTP---------------------------------------------------------------------- -------------------ECPVRTPSLGRS------------------------------------------------- ----------------------------------------------------KQRKGPLSLQDFRMIAVLGRGHFGKVLL SEYKKTGTMYAIKALKKGDIIARDEVE---SLMCEKRIFEIVN-VSHHPFLVNLFACFQTPEHVCFVMEYTAGGDL--MM HIHTDVFTEPRAM-FYSACVVLGLQFLHDHKIVY---RDLKLDNLLLDTDGYVKIADFGLCKEGMGFGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSNEAIGIIRR--LLRRNPE RRLGSGEKDAEEVKKQPFFR--TMDWEALLQRKVPPPFLPSITGKEDVSNFDEEFTTEAPTLTPPRE-------PRMLTR KDQESFRDFDYVSDLC----------- >Gasterosteus_aculeatus_PKN1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------FLFLVVQ---------SDPGGLSVLEQLGLDQNSDFSDTGVQQLLDEHRERIRRE----------------- --------------------------IRRELKIKEGAENLRRATTDK-RNAQQVESQLRSSN------------------ ------------------------------------RKLDDLHAQLQELDAHIVHLVPSIG--------------TDECP QSPG------------------AESR--TSAHKERIAALERQLNIELKVKQGVEN---------------------MIPI YGLQSPF----------NQDKKMLQTAQQMQQDSKTKIDIIRMQIRKAV---------------QATEHNEDTQAPN--- ----TAGNQDLCGMELRIEELRHHYRVEHAVAEGAKNVLRLLGAGKVQDK------------------------------ -----------------KALSEAQSRLSEASQRLDLLRDSLDQRLAELP------EDHPKATVIKEELVLASS------- --PAFSSRHGAPYLHNQYNTLN-----KPSPLTG-TLQVQVLGCVGLLE-------VVPGRTKGVAVMLPCYSPGDTR-- SFMRGSKGLYGR---SGSVSGKTPSKAEELSL-----------AEVSAVLKLDNGVVGQTAW-KTVGEQAWDQTFTVE-- LERSREMEIAVYWKD--YRSLCALKYLKLEEFLDN-QKHRVQLELEPQGLLMAEVIFFNPVIERV-PRLQRQKKVFS-KQ QGKAFLRARQMNVDIGTWVRLLRNAIPTANN------SGTYSPNTQG-----------------LMLSA----------- ------------------GEVSVEKLNLDSDSP----------------------MRVFLSS------------------ -------------------------------RVPPQD------------------------------------------- ---------------------------------------------------------------------------RLTVI EPFSPPDLTP---------------------------------------------------------------------- -------------------ECPVRTQSIGRLR------------------------------------------------ -----------------------------------------------VRLSSKQRKGPLSLQDFRLIAVLGRGHFGKVLL SEYKKTGTMYAIKALKKGDIVARDEVE---SLMCEKRIFEVVN-MSHHPFLVNLFACFQTPQHVCFVMEYTAGGDL--MM HIHTDVFTEPRAV-FYAACVVLGLQFLHDHKIVY---RDLKLDNLLLDTDGYVKIADFGLCKEGMGFGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAIGIMRR--LLRRNPE RRLGSGEKDAEEVKKQPFFR--HVDWEALLQKKVPPPFIPSIVGKEDVSNFDEEFTAEAPALTPPRE-------PRVLSR KDQESFCDFDYVSDLC----------- >Oryzias_latipes_PKN1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MANDSVQ---------SDPGGLSVLELLGLDQSSDFSDSSVQQLLDEQRERIRRE----------------- --------------------------IRKELKIKEGAENLRRATTDK-RNAQQVESQLRTSN------------------ ------------------------------------RRLDHLHAQLQELDAHIVVKGGEEN--------------KDECP QSPG------------------AESR--TSAHRDRIAALERQLNIELKVKQGVEN---------------------MIPI YANGS------------TKDKKMLQTAQQMLQDSKTKIDIIRMQIRKAV---------------QATEHSDDTQG----- -------NQDLCGVELRIEELRHHYRVEHAVAEGAKNVLRLLGASKVQDK------------------------------ -----------------KALSEAQSRLGEASQRLDLLRDSLDRRLAELP------EDHPKANVIKEELVLAAS------- --PAFSSRHGAPYLHNQYSTLN-----KPSPLTG-TLQVQLLGCVGLLE-------TVPGRSKGSAVTLPCYSPGDSR-- SFMRSSKGLYGR---TGSVSGKTPNKSDELS------------TEVSAVLKLDNGVVGQTAW-RTVGEQAWDQTFTVE-- LERSREMEIAVYWRD--FRSLCALKYLKLEEFLDN-QKHRVQVELEPQGLLLAEVTFFNPVIERV-PRLQRQKKVFS-KQ QGKAFLRARQMNVDIGTWVRLLRNAIPTANN------SGTYSPTAHS-----------------LSLNS----------- ------------------GEISVEKLSLDSDTPLRGDYKRDTDQQTPVRRKGNLGKRDKIKK------------------ -------------------------------MILNLEARANF-------------------------------------- ---------------------------------------------------------------------------RRVFE DVVGVNGFSSKEKDL----------------------------------------------------------------- ----------------HKYDGAFSSTSISNLT------------------------------------------------ ---------------------------------------------QFDDLLSEEKKGPLSLQDFRLIAVLGRGHFGKVLL SEYKKTGTMYAIKALKKGDIIARDEVD---SLMCEKRIFEIVN-MSHHPFLINLFACFQTSQHVCFVMEYTAGGDL--MM HIHTDVFTEPRAV-FYAACVVLGLQFLHDHKIVY---RDLKLDNLLLDTDGYVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAIGIMRR--LLRRNPE RRLGSGEKDAEEVKKQPFFR--SVDWEALLQRKVPPPFVPSIRGKEDVSNFDEEFTTEPPTLTPPRE-------ARSLTR KDQDCFRDFDYVSDLC----------- >Oryzias_latipes_PKN1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------ISLSPLQ---------TDPNGLSVLQQLGLDQNSDFSDCSVQQRLDEHRERIRRE----------------- --------------------------IRKELKIKEGAENLRRAT-DK-RNVQQVDSQLRSSK------------------ ------------------------------------RKLESLHAQLQELDAHIVVKGQEENKVT----------PVSDDS KSPG------------------SVNR--TSANQHRIAALERQLNIELKVKQGAEN---------------------MIPI YASGG------------TKDKKLLQTAQQMLQDSKTKIDIIRMQIRKAM---------------QATEQSEDNQS----- -------KPDLCGVELRVEELWHHYRVEHAMAEGAKNMLRLLGAGKVQDK------------------------------ -----------------KAINEAQCGLSGSSQRLDLLRCALEQRLQELP------EDHPKVCLIKEELVLASS------- --SAFSSSHSTPYVHNQYSTLS-----KPSPLTG-TLQVRLLGCVGLLE-------VVPGRSKGAPVVLPSYSTSDGR-- PSFKLS-GLYSRS--TSSMSLKIPSKNEELS------------SEVSAVLKLENTVVGQTAW-RTVGEQAWDQSFTLE-- LERSREMEIAVYWRD--YRSLCALKYLKLEDFLDN-QRHQVQLELEPQGLLVAEVTFFNPVIERG-RRLQRQKKVFS-KQ HGKAFLRARQMNVDIATWVRLLRNAIPSGSNPPSLFTSNTLSQAPGY-----------------VRESN----------- ------------------DHSSFIKLLINTVGG-------------GIRSGVMNDSCLLLQM------------------ -------------------------------LVARLPPFSS--------------------------------------- ---------------------------------------------------------------------------LFLLL PCSSQQDQTPVIEAP----------------------------------------------------------------- ----------------PTAEVPAHKQPARSPS------------------------------------------------ -----------------------------------------------QNSLRRASRGPVSLQDFKLLAVLGRGHFGKVLL SEYKKTGGLFAIKALKKGDIVARDEVE---SLMCEKRIFETVN-GSHHPFLVNLFACFQTPEHVCFVMEYTAGGDL--MM HIHADVFAEPRAV-FYSACVVLGLQFLHDHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGFGDRTSTFCGTPEF LAPEVLT-DTSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAIGIMRR--LLRRNPE RRLGSGEKDAEDVKKQPFFR--NTDWEGLLHRKVSPPFVPTIVGKEDVSNFDAEFTAEPAALTPPRE-------RRTLSQ KEQDFFKDFDYVSDLC----------- >Ciona_savignyi_PKN1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------PPPP----PDPAIP------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------PEEQQKDP------RIGGLEKQLRIEMMVKQGAEN---------------------MMKS YTSGH------------GKDRKLIATAEQMLSESKTKIEVIRMQILQLK--THAAS-----------VASR--------- ------STDGNDGLPVRIAMLRHHVKIESAIVEGSKNVVRFMAEGKQ--------------------------------- -----------DLTQTICYFNPAIALFDTEARLLPLLSPTTPNHHHPLF------KPHVKSHPSLIYLTLIRI------- ----WCFNNSFIVVILVLPPHHPNTSPT---HPG-KLEVRLVGCQDLLD-------NVPGRSRNMSIQLPATSP-ENR-A WIRGGSKSFHG------KASNKYNVKPDDLSS------------DASLFNHVPSGVL----------------------- ------LEVALF-----WRFYNNCPHIEIIYTLSH-RNHKVALNMH----MTSQVTFSNPKIERK-PKLQRQKKIFR--N KGKSFLRAKQMNINIATWSRLMKRAIPPC------NDPNTFSPPSDV-------------------PAQ----------- ------------------EPHPAGKPPLGNPP--VKTDSLNVSLSLSHTHPHDSPPSPITPQ------------------ ------------------------------EMMSNIE------------------------------------------- ----------------------------------------------------------------------------LEKP KPAPRRNKES---------------------------------------------------------------------- -------------------FIQWNQPSSPPKPARRS-------------------------------------------- ---------------------------------------NT-----PQAPDSGAKPRQIVMEDFKTIAVLGRGHFGKVLL TQHKQTGRMYAIKALKKGDIIARDEID---SLMVERRIFECAT-KVKHPFLVNLYACFQTPQHVCFVTEYASGGDL--ML HIHTDVFNEPRTV-FYTSCVVLGLQYLHENKIVY---RDLKLDNL----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------- >Homo_sapiens_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KSLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSDPEDIT---------------DCP RTPD-----------------TPNNDPRCSTSNNRLKALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNEVP------KNHPKSRIIIEELSLVAAS------ --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVALPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLSN------------DVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQAPVPTTVP---VVDVRIPQLAPPA------------ ------------------SDSTVTKLDFDLEPEPPPAPPRASSLGEID-ESSELRVLDIPGQ------------------ ------------------------------DSETVFD------------------------------------------- ----------------------------------------------------------------------------IQND RNSILPKSQS---------------------------------------------------------------------- -----------------EYKPDTPQSGLEYSGIQE--------------------------------------------- -----------------------------------------------LEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLL AEYKNTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGASEKDAEDVKKHPFFR--LIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQEMFRDFDYIADWC----------- >Pan_troglodytes_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KSLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSDPEDIT---------------DCP RTPD-----------------TPNNDPRCSTSNNRLKALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNEVP------KNHPKSRIIIEELSLVAAS------ --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVALPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLSN------------DVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQAPVPTTVP---VVDVRIPQLAPPA------------ ------------------SDSTVTKLDFDLEPEPPPAPPRASSLGEID-ESSELRVLDTPGQ------------------ ------------------------------DSETVFD------------------------------------------- ----------------------------------------------------------------------------IEND RNSILPKSQS---------------------------------------------------------------------- -----------------EYKPDTPQSGLEYSGIQE--------------------------------------------- -----------------------------------------------LEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLL AEYKHTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGASEKDAEDVKKHPFFR--LIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQEMFRDFDYIADWC----------- >Pongo_abelii_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MASNPEGGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KSLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSGPEDIT---------------DCP RTPD-----------------TPNSDPRCSTSNNRLKALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------KNHPKSSIIIEELSLVAAS------ --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVALPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLSN------------DVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQAPVPTTVP---VVDVRIPELAPPA------------ ------------------SDSTVTKLDFDLEPEPPPAPPRASSLGEID-ESSELRVLDTPGQ------------------ ------------------------------DSETVFD------------------------------------------- ----------------------------------------------------------------------------IEND RNSILPKSQS---------------------------------------------------------------------- -----------------EYKPDTPQSGLEYSGIQE--------------------------------------------- -----------------------------------------------LEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLL AEYKHTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGASEKDAEDVKKHPFFR--LIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQEMFRDFDYIADWC----------- >Macaca_mulatta_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------GDSRSLPFSENVSAVQKLDFSDTVVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KSLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSDPEDIT---------------DCP RTPD-----------------TPNSDPRCSTSNNRLKALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------KNHPKSSIIIEELSLVAS------- --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVALPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLSN------------DVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPPGLYLQRVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQAPVPTTVP---VVDVRIPELAPPA------------ ------------------SDSTVTKLDFDLEPEPPPAPPRASSLGEID-ESSELR------------------------- ------------------------------DSETVFD------------------------------------------- ----------------------------------------------------------------------------IEND RNSILPKSQS---------------------------------------------------------------------- -----------------EYKPDTPR-ALEYSGIQE--------------------------------------------- -----------------------------------------------LED--SQQRFQFNLQDFRCCAVLGRGHFGKVLL AEYKHTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGASEKDAEDVKKHPFFR--LIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQEMFRDFDYIADWC----------- >Mus_musculus_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MASNPDRGEILLTELQGDSRTLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KNLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSDPEDST---------------DCP RTPD-----------------TPNSDSRSSTSNNRLMALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFKIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------RNHPKSSVVIEELSLVAS------- --PTLSPRQSMLSTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVALPGWSPSDNRSS FMSRTSKSKSG--------SSRNLLKTDDLSN------------DVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQTPVPATVP---VVDARIPDLAPPA------------ ------------------SDSTVTKLDFDLEPEPPPAPPRASSLGETD-ESSELRVLDIPGQ------------------ ------------------------------GSETVFN------------------------------------------- ----------------------------------------------------------------------------IEND RNNLRPKSKS---------------------------------------------------------------------- -----------------EYELSIPDSGRSCWGVGE--------------------------------------------- -----------------------------------------------LDDKRAQQRFQFSLQDFRCCAVLGRGHFGKVLL AEYKHTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGAGEKDAEDVKKHPFFR--LTDWSALMDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILLE EEQEMFHDFDYVADWC----------- >Rattus_norvegicus_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MASNPDRGEILLTELQGDSRPLPFSENVSAVQKLDFSDTIVQQKLDDVKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KNLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSDPEDSA---------------DCP RTPD-----------------TPNSDSRSSTSNNRLMALQKQLDIELKVKQGAEN---------------------MIQM YSNGP------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------KNHPKSSVVIEELSLVAS------- --PTLSPRQSMLSTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVALPGWSPSENRSS FMSRTSKSKSG--------SSRNLLKTDDLSN------------DVCAVLKLDNTVVGQTIW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQTPVPATVP---VVDARTPELAPPA------------ ------------------SDSTVTKLDFDLEPEAPPAPPRASSLGEID-DSSELRVLDIPGQ------------------ ------------------------------GSETVFD------------------------------------------- ----------------------------------------------------------------------------IEND RNNMRPKSKS---------------------------------------------------------------------- -----------------EYELNIPDSSRSCWSVGE--------------------------------------------- -----------------------------------------------LEDKRSQQRFQFNLQDFRCCAVLGRGHFGKVLL AEYKHTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGAGEKDAEDVKKHPFFR--LTDWSALLDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILLE EEQEMFRDFDYVADWC----------- >Oryctolagus_cuniculus_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MASNPERGEILLTELQGDSRSLPFPENVSAVQKLDFSDTMVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KSLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSDPEDVT---------------DCP RTPD-----------------TPNSDPRSSTSNNRLMALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------MAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------KNHPKSSIIIEELSLVAS------- --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVALPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLS------------NDVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQTPVPASVA---VVDVRIPEIAPPA------------ ------------------SDSTVTKLDFDLEPEPPPAPPRASSLGEID-ESSELRVLDTAGQ------------------ ------------------------------DSETGFD------------------------------------------- ----------------------------------------------------------------------------IEND RNSILPKSQS---------------------------------------------------------------------- -----------------EYEPDIPQSGLEYGDIRE--------------------------------------------- -----------------------------------------------LENRRSQQRFQFNLQDFRCCAVLGRGHFGKVLL AEYKNTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGAGEKDAEDVKKHPFFR--LIDWSALMDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQELFRDFDYIADWC----------- >Canis_familiaris_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------KNHPKSSIIIEELSLVAS------- --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVALPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLS------------NDVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQAPVPTTVP---VVDVRIPELAPPA------------ ------------------SDSTVTKLDFDLEPEPPPAPPRDSSLGEID-ESAKLRDLDTPAQ------------------ ------------------------------DSETVFD------------------------------------------- ----------------------------------------------------------------------------IEND RNSILPKSPS---------------------------------------------------------------------- -----------------EYEPNIPQPGLGYSGIRE--------------------------------------------- -----------------------------------------------LEDRRSQQMFQFNLQDFRCCAVLGRGHFGKVLL AEYKHTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGAGEKDAEDVKKHPFFR--LIDWSALMDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQEMFRDFDYIADWC----------- >Felis_catus_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------LVSCLLRKELNVIRYNGDSRSLPFSENVSAVQKLDFSDTVVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-K-LAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSDPEDVT---------------DCP RTPD-----------------TPSSDPRCSTSNNRLMALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------KNHPKSSIIIEELSLVAS------- --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVALPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLS------------NDVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQASVPATVP---VVDVRIPELVSSI------------ ------------------SDSTVTKLDFDLEPEPPPAPPRDSSLGEID-ESAELRDSDTPRQ------------------ ------------------------------DSEAVFA------------------------------------------- ----------------------------------------------------------------------------IEND RNSILPKSQS---------------------------------------------------------------------- -----------------EYEPDIPQPGLGYSGVRE--------------------------------------------- -----------------------------------------------LEDRRSQQMFQFNLQDFRCCAVLGRGHFGKVLL AEYKHTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVYSLNRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGAGEKDAEDVKKHPFFR--LIDWSALMDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQEMFRDFDYIADWC----------- >Bos_taurus_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KSLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSDPEDVT---------------DCP RTPD-----------------TPSSDSRCSTSNNRLMALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------KNHPKSSIIIEELSLVAS------- --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKAASVALPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLS------------NDVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQAPVPATVP---VVDVHIPELAPPA------------ ------------------SDSTVTKLDFDLEPEPPPAPPRDSSLGEID-ESA--RDLDTPGQ------------------ ------------------------------DSETVFD------------------------------------------- ----------------------------------------------------------------------------TEND RNRILPKSQS---------------------------------------------------------------------- -----------------EYEPDIPQSGLEYSGIHE--------------------------------------------- -----------------------------------------------LEDRRSQQMFQFSLQDFRCCAVLGRGHFGKVLL AEYKHTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGAGEKDAEDVKKHPFFR--LIDWSALMDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQEMFRDFDYIADWC----------- >Loxodonta_africana_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------GDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KSLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVSDSEDVT---------------DCP RTPD-----------------TPNNDPRCSTSNNRLMALQKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLHGTAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFKIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------KNHPKSSIIIEELSLVAS------- --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKAASVALPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLSSSV---------NDICAFLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-IQ QGKTFLRAPQMNINIATWGRLVRRAF--L------NHTGTFSPPASVPAAVP---AVDVRIPELAPPA------------ ------------------SDPTVTKLDFDFEPELPLAPLRASSLGEID-ESTELRVLDEPNQ------------------ ------------------------------DSASTFD------------------------------------------- ----------------------------------------------------------------------------IEND RNSILQKSQP---------------------------------------------------------------------- -----------------EYELDIPQSGLDYSDIRE--------------------------------------------- -----------------------------------------------LEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLL AEYKHTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVYSLNRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGASEKDAEDVKKHPFFR--LIDWNTLMDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQEMFRDFDYIADWC----------- >Monodelphis_domestica_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MASNTERGEILLTELQGDARSLLLPENVSTGQKLDFSDTMVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KNLAYVDNILKKSN------------------ ------------------------------------KKLEELHHKLQELNAHIVVTDPEDLT---------------DCP RTPD-----------------TPNSDPRCATSN-KLMALKKQLDIELKVKQGAEN---------------------MIQM YSNGS------------SKDRKLLATAQQLLQDSKTKIEVIRMQILQA---VQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVADR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLSELP------KNHPKSSIIIEELSLVGS------- --PTLSPRQSVISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVTLPGWSPSETRSS FMSRTSKSKSG--------SSRNLLKTDDLSN------------DICAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQAPGPTTVP---VVDVRIPELSPPA------------ ------------------SDSTVTKLDFELEPEAPPAPPRTSSFGEIH-EPSELRVLDVSGQ------------------ ------------------------------DSETTFN------------------------------------------- ----------------------------------------------------------------------------FEND RNSIVPKNQP---------------------------------------------------------------------- -----------------EYEPPVLQSSLEYGGVQE--------------------------------------------- -----------------------------------------------PEERRSPQRFQFSLQDFRCCAVLGRGHFGKVLL AEYKNTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVY---RDLKLDNLLLDTEGFVKIADFGLCKEGMGFGDRTSTFCGTPEF LAPEVLT-ETSYTRAVDWWGLGVLIYEMLVGESP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGAGEKDAEDVKKHPFFR--LIDWNALLAKKVKPPFVPTIRGREDR--------------IPLSC-------ACLKWK EEQLVI--------------------- >Ornithorhynchus_anatinus_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------QGDTRSLLLPDNVSAGQKLDFSDTMVQQKLDDIKDRIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KNLAYVDNILKKSN------------------ ------------------------------------KKLEELHHRLQELNAHIVVTDPEDLTD--------------SCL RTPDPCL-------------HTPESQSNGNVSANPLIPRKSQLCFRLTVHWGSNN---------------------SLAM YSSGS------------SDDRKLLATAQQLLQDSKTKIEVIRMQILQA---IQTNE-----------LAFDNA------- -------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDR------------------------------ -----------------KALSEAQARFNESSQKLDLLKYSLEQRLNELP------KNHPKSSIIIEELSLVSS------- --PTLSPRQSMISTQNQYSTLS-----KPAALTG-TLEVRLMGCQDILE-------NVPGRSKATSVTLPGWSPSEARSS FMSRTSKSKSG--------SSRNLLKTDDLSR-----------DEVCAVLKLDNTVVGQTSW-KPISNQSWDQKFTLE-- LDRSRELEISVYWRD--WRSLCAVKFLRLEDFLDN-QRHGMCLYLEPQGTLFAEVTFFNPVIERR-PKLQRQKKIFS-KQ QGKTFLRAPQMNINIATWGRLVRRAIPTV------NHSGTFSPQAPVSAPVP---VVDVRIPELAAPA------------ ------------------SDSTVTKLDFELEPDPPTAPPRASSLGEIHDSSSESKVLDPPVK------------------ ------------------------------DSETVFD------------------------------------------- ----------------------------------------------------------------------------IDNG RN-IVPKSQPE--------------------------------------------------------------------- ----------------IIYEPDIPQSGLEFSPVRE--------------------------------------------- -----------------------------------------------PEDRRSQQRFQFSLQDFRCCAVLGRGHFGKVLL AEYKNTNEMFAIKALKKGDIVARDEAD---SLMCEKRIFETVN-SVRHPFLVNLFACFQTKDHVCFVMEYAAGGDL--MM HIHTDVFSEPRAV-FYAACVVLGLQYLHEHKIVYSPNRDLKLDNLLLDTEGFVKIADFGLCKEVMECPDRRLTRCCSFLC FPPETFT-ETNLNSRLTFW-FGLKVVETVELHSP-FP--GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR--LLRRNPE RRLGAAEKDAEDVKKHPFFRVSMKDWNALMAKKLKPPFVPTIRGREDVSNFDDEFTSEAPILTPPRE-------PRILSE EEQEMFTDFDYIADWC----------- >Gallus_gallus_PKN2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------MVQQKLDEIKDQIKRE----------------- --------------------------IRKELKIKEGAENLRKVTTDK-KNLAYVDNILKKSN------------------ ------------------------------------KKLEDLHHKLQELNAHIVVTDPEDVA---------------DCP RTPD-----------------TPNSDPR-FPTNNRLMALKKQLDIELKVK